locus-tag	class	description
FTU_RS00025	COG1012	belongs to the aldehyde dehydrogenase family
FTU_RS00035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FTU_RS00080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FTU_RS00100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FTU_RS00130	COG2814	Major facilitator Superfamily
FTU_RS00135	COG0019	diaminopimelate decarboxylase activity
FTU_RS00140	COG2814	Major facilitator Superfamily
FTU_RS00145	COG4264	IucA IucC family
FTU_RS00155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FTU_RS00175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FTU_RS00185	COG1034	ATP synthesis coupled electron transport
FTU_RS00200	COG0839	Belongs to the complex I subunit 6 family
FTU_RS00250	COG2251	uridine kinase activity
FTU_RS00250	COG0195	Participates in both transcription termination and antitermination
FTU_RS00275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FTU_RS00280	COG0564	pseudouridine synthase activity
FTU_RS00340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FTU_RS00355	COG2223	nitrite transmembrane transporter activity
FTU_RS00370	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FTU_RS00375	COG1053	succinate dehydrogenase
FTU_RS00380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FTU_RS00410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FTU_RS00435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FTU_RS00470	COG1294	oxidase, subunit
FTU_RS00480	COG1090	epimerase
FTU_RS00525	COG1619	proteins homologs of microcin C7 resistance protein MccF
FTU_RS00545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FTU_RS00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTU_RS00575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTU_RS00575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTU_RS00585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FTU_RS00590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FTU_RS00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTU_RS00600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTU_RS00620	COG0552	protein localization to endoplasmic reticulum
FTU_RS00625	COG0210	DNA helicase
FTU_RS00645	COG0444	Belongs to the ABC transporter superfamily
FTU_RS00650	COG4608	Belongs to the ABC transporter superfamily
FTU_RS00690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FTU_RS00705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTU_RS00735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FTU_RS00815	COG4974	Belongs to the 'phage' integrase family
FTU_RS00855	COG3023	N-Acetylmuramoyl-L-alanine amidase
FTU_RS00865	COG2814	Major facilitator Superfamily
FTU_RS00870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTU_RS00890	COG2890	protein-(glutamine-N5) methyltransferase activity
FTU_RS00920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FTU_RS00930	COG0456	acetyltransferase
FTU_RS00935	COG0189	ligase activity
FTU_RS00935	COG4067	protein conserved in archaea
FTU_RS00945	COG0204	Acyl-transferase
FTU_RS00975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FTU_RS00995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FTU_RS01005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FTU_RS01015	COG2862	Uncharacterized protein family, UPF0114
FTU_RS01025	COG2066	Belongs to the glutaminase family
FTU_RS01040	COG3040	lipid binding
FTU_RS01050	COG0814	amino acid
FTU_RS01065	COG0138	bifunctional purine biosynthesis protein purh
FTU_RS01090	COG1121	(ABC) transporter
FTU_RS01115	COG1295	ribonuclease BN
FTU_RS01125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FTU_RS01165	COG3511	phospholipase C
FTU_RS01170	COG1984	allophanate hydrolase subunit 2
FTU_RS01215	COG1560	Kdo2-lipid A biosynthetic process
FTU_RS01220	COG1560	Kdo2-lipid A biosynthetic process
FTU_RS01235	COG0594	ribonuclease P activity
FTU_RS01250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FTU_RS01260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FTU_RS01285	COG0589	response to stress
FTU_RS01305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FTU_RS01315	COG0574	Belongs to the PEP-utilizing enzyme family
FTU_RS01315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FTU_RS01325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FTU_RS01350	COG0557	exoribonuclease II activity
FTU_RS01395	COG1116	anion transmembrane transporter activity
FTU_RS01410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FTU_RS01455	COG1294	oxidase, subunit
FTU_RS01460	COG1271	oxidase subunit
FTU_RS01465	COG2814	Major facilitator Superfamily
FTU_RS01470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FTU_RS01475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FTU_RS01485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FTU_RS01505	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FTU_RS01515	COG0714	Associated with various cellular activities
FTU_RS01535	COG2304	oxidoreductase activity
FTU_RS01550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FTU_RS01565	COG0525	valine-tRNA ligase activity
FTU_RS01585	COG1304	FMN binding
FTU_RS01600	COG0114	fumarate hydratase activity
FTU_RS01620	COG0531	amino acid
FTU_RS01635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FTU_RS01660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FTU_RS01665	COG0575	Belongs to the CDS family
FTU_RS01675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTU_RS01800	COG0201	protein transport
FTU_RS01880	COG0300	oxidoreductase activity
FTU_RS01915	COG1294	oxidase, subunit
FTU_RS01920	COG1271	oxidase subunit
FTU_RS01925	COG2814	Major facilitator Superfamily
FTU_RS01930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FTU_RS01935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FTU_RS01945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FTU_RS01965	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FTU_RS01975	COG0714	Associated with various cellular activities
FTU_RS01995	COG2304	oxidoreductase activity
FTU_RS02010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FTU_RS02025	COG0525	valine-tRNA ligase activity
FTU_RS02045	COG1304	FMN binding
FTU_RS02060	COG0114	fumarate hydratase activity
FTU_RS02080	COG0531	amino acid
FTU_RS02095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FTU_RS02120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FTU_RS02125	COG0575	Belongs to the CDS family
FTU_RS02135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTU_RS02260	COG0201	protein transport
FTU_RS02340	COG0300	oxidoreductase activity
FTU_RS02380	COG2918	glutathione biosynthetic process
FTU_RS02385	COG0728	peptidoglycan biosynthetic process
FTU_RS02395	COG0802	atpase or kinase
FTU_RS02400	COG0285	dihydrofolate synthase activity
FTU_RS02405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FTU_RS02450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FTU_RS02480	COG1056	cytidyltransferase-related domain
FTU_RS02480	COG1051	belongs to the nudix hydrolase family
FTU_RS02490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTU_RS02515	COG0024	Methionine aminopeptidase
FTU_RS02530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FTU_RS02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FTU_RS02550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FTU_RS02560	COG0587	DNA-directed DNA polymerase activity
FTU_RS02565	COG0242	peptide deformylase activity
FTU_RS02585	COG1982	Orn Lys Arg decarboxylase major
FTU_RS02595	COG0509	glycine decarboxylation via glycine cleavage system
FTU_RS02615	COG1523	belongs to the glycosyl hydrolase 13 family
FTU_RS02625	COG0033	Phosphoglucomutase
FTU_RS02640	COG0058	SHG alpha-glucan phosphorylase activity
FTU_RS02645	COG1640	4-alpha-glucanotransferase
FTU_RS02655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTU_RS02665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FTU_RS02675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FTU_RS02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FTU_RS02700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FTU_RS02725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FTU_RS02730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FTU_RS02735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FTU_RS02740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTU_RS02760	COG2814	Major facilitator Superfamily
FTU_RS02780	COG3104	oligopeptide transport
FTU_RS02790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FTU_RS02795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FTU_RS02810	COG0772	Belongs to the SEDS family
FTU_RS02820	COG0463	Glycosyl transferase, family 2
FTU_RS02825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FTU_RS02835	COG2920	part of a sulfur-relay system
FTU_RS02840	COG0625	glutathione transferase activity
FTU_RS02845	COG0616	signal peptide processing
FTU_RS02850	COG0470	DNA polymerase III
FTU_RS02860	COG0113	porphobilinogen synthase activity
FTU_RS02865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FTU_RS02870	COG0252	asparaginase activity
FTU_RS02885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTU_RS02895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FTU_RS02905	COG0511	ligase activity, forming carbon-carbon bonds
FTU_RS02910	COG0439	Biotin carboxylase
FTU_RS02930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FTU_RS02930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FTU_RS02935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FTU_RS02945	COG0531	amino acid
FTU_RS02960	COG1162	GTPase activity
FTU_RS02975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FTU_RS02995	COG0492	ferredoxin-NADP+ reductase activity
FTU_RS03000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTU_RS03005	COG0546	phosphoglycolate phosphatase activity
FTU_RS03010	COG0583	DNA-binding transcription factor activity
FTU_RS03050	COG0628	permease
FTU_RS03065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FTU_RS03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTU_RS03130	COG3961	Belongs to the TPP enzyme family
FTU_RS03155	COG2264	protein methyltransferase activity
FTU_RS03160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTU_RS03170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FTU_RS03185	COG2852	Protein conserved in bacteria
FTU_RS03190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FTU_RS03225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FTU_RS03280	COG2824	Alkylphosphonate utilization operon protein PhnA
FTU_RS03305	COG1876	peptidase activity
FTU_RS03320	COG1012	belongs to the aldehyde dehydrogenase family
FTU_RS03330	COG1937	Protein conserved in bacteria
FTU_RS03340	COG0583	DNA-binding transcription factor activity
FTU_RS03375	COG3842	ATPase activity
FTU_RS03380	COG1176	ABC-type spermidine putrescine transport system, permease component I
FTU_RS03385	COG1177	transmembrane transport
FTU_RS03410	COG0560	Phosphoserine phosphatase
FTU_RS03445	COG0077	Prephenate dehydratase
FTU_RS03445	COG1605	Chorismate mutase
FTU_RS03455	COG1760	l-serine dehydratase
FTU_RS03460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FTU_RS03465	COG0316	Belongs to the HesB IscA family
FTU_RS03470	COG2151	metal-sulfur cluster biosynthetic enzyme
FTU_RS03480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FTU_RS03515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FTU_RS03530	COG0252	asparaginase activity
FTU_RS03535	COG0288	reversible hydration of carbon dioxide
FTU_RS03545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FTU_RS03550	COG1773	rubredoxin
FTU_RS03570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTU_RS03665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FTU_RS03670	COG4535	Mg2 and Co2 transporter CorC
FTU_RS03680	COG1702	phosphate starvation-inducible protein PhoH
FTU_RS03690	COG4122	O-methyltransferase activity
FTU_RS03700	COG1435	thymidine kinase activity
FTU_RS03720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FTU_RS03725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FTU_RS03750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FTU_RS03760	COG0330	HflC and HflK could
FTU_RS03765	COG0330	HflC and HflK could
FTU_RS03770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FTU_RS03790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FTU_RS03815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FTU_RS03820	COG0670	Belongs to the BI1 family
FTU_RS03835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FTU_RS03840	COG2878	Part of a membrane complex involved in electron transport
FTU_RS03845	COG2999	glutathione oxidoreductase activity
FTU_RS03850	COG3104	oligopeptide transport
FTU_RS03855	COG1528	Iron-storage protein
FTU_RS03865	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FTU_RS03885	COG0632	four-way junction helicase activity
FTU_RS03915	COG0076	glutamate decarboxylase activity
FTU_RS03970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FTU_RS03980	COG4536	flavin adenine dinucleotide binding
FTU_RS03985	COG2226	methyltransferase
FTU_RS03995	COG0012	GTP binding
FTU_RS04015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FTU_RS04030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FTU_RS04035	COG3104	oligopeptide transport
FTU_RS04045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FTU_RS04055	COG0095	Lipoate-protein ligase
FTU_RS04060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FTU_RS04075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FTU_RS04080	COG0204	Acyl-transferase
FTU_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
FTU_RS04090	COG3116	cell division
FTU_RS04145	COG1940	carbohydrate kinase activity
FTU_RS04170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FTU_RS04175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FTU_RS04180	COG0814	amino acid
FTU_RS04190	COG0156	8-amino-7-oxononanoate synthase activity
FTU_RS04220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FTU_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS04255	COG2271	Major facilitator Superfamily
FTU_RS04260	COG0584	glycerophosphoryl diester phosphodiesterase
FTU_RS04270	COG1131	(ABC) transporter
FTU_RS04275	COG0842	Transport permease protein
FTU_RS04295	COG0386	Belongs to the glutathione peroxidase family
FTU_RS04330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FTU_RS04330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FTU_RS04335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FTU_RS04405	COG1509	lysine 2,3-aminomutase activity
FTU_RS04410	COG1278	Cold shock
FTU_RS04440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FTU_RS04445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FTU_RS04475	COG0084	hydrolase, TatD family'
FTU_RS04480	COG0751	glycine-tRNA ligase activity
FTU_RS04490	COG0813	purine-nucleoside phosphorylase activity
FTU_RS04545	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FTU_RS04580	COG1611	Belongs to the LOG family
FTU_RS04600	COG3220	belongs to the UPF0276 family
FTU_RS04615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FTU_RS04615	COG0517	IMP dehydrogenase activity
FTU_RS04620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FTU_RS04625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FTU_RS04630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FTU_RS04640	COG1132	(ABC) transporter
FTU_RS04655	COG3475	LICD family
FTU_RS04660	COG1216	Glycosyl transferase, family 2
FTU_RS04660	COG1442	glycosyl transferase family 8
FTU_RS04665	COG1216	Glycosyl transferase, family 2
FTU_RS04665	COG1442	glycosyl transferase family 8
FTU_RS04670	COG0438	transferase activity, transferring glycosyl groups
FTU_RS04690	COG1446	asparaginase
FTU_RS04720	COG0477	Major facilitator Superfamily
FTU_RS04740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTU_RS04760	COG0509	glycine decarboxylation via glycine cleavage system
FTU_RS04810	COG1051	belongs to the nudix hydrolase family
FTU_RS04840	COG2985	domain, Protein
FTU_RS04865	COG4401	Chorismate mutase type I
FTU_RS04870	COG1183	phosphatidylcholine synthase activity
FTU_RS04880	COG0811	peptide transport
FTU_RS04925	COG0415	Belongs to the DNA photolyase family
FTU_RS04930	COG3046	protein related to deoxyribodipyrimidine photolyase
FTU_RS04940	COG0385	Bile acid
FTU_RS04965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FTU_RS04970	COG2363	Small membrane protein
FTU_RS05010	COG1704	LemA family
FTU_RS05090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTU_RS05090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTU_RS05105	COG0833	amino acid
FTU_RS05120	COG0436	Aminotransferase
FTU_RS05130	COG0497	DNA recombination
FTU_RS05150	COG4969	Belongs to the N-Me-Phe pilin family
FTU_RS05155	COG0671	phosphoesterase, PA-phosphatase related
FTU_RS05165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FTU_RS05175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FTU_RS05195	COG0339	signal peptide processing
FTU_RS05235	COG1192	Involved in chromosome partitioning
FTU_RS05240	COG1475	DNA binding
FTU_RS05245	COG0519	Catalyzes the synthesis of GMP from XMP
FTU_RS05280	COG0196	riboflavin kinase activity
FTU_RS05285	COG0281	malic enzyme
FTU_RS05340	COG0189	ligase activity
FTU_RS05350	COG1472	Belongs to the glycosyl hydrolase 3 family
FTU_RS05370	COG1940	carbohydrate kinase activity
FTU_RS05390	COG0156	8-amino-7-oxononanoate synthase activity
FTU_RS05400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FTU_RS05405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FTU_RS05420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FTU_RS05420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FTU_RS05425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FTU_RS05435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FTU_RS05435	COG0512	Glutamine amidotransferase of anthranilate synthase
FTU_RS05440	COG0512	Glutamine amidotransferase of anthranilate synthase
FTU_RS05440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FTU_RS05450	COG0667	Aldo Keto reductase
FTU_RS05455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FTU_RS05470	COG0302	gtp cyclohydrolase
FTU_RS05475	COG0513	Belongs to the DEAD box helicase family
FTU_RS05480	COG3104	oligopeptide transport
FTU_RS05490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTU_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS05510	COG0708	Exodeoxyribonuclease III
FTU_RS05520	COG2249	NAD(P)H dehydrogenase (quinone) activity
FTU_RS05530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FTU_RS05535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FTU_RS05565	COG0531	amino acid
FTU_RS05570	COG0569	domain protein
FTU_RS05580	COG0719	Fe-S assembly protein
FTU_RS05585	COG0396	ATPase activity
FTU_RS05590	COG0719	Fe-S assembly protein
FTU_RS05625	COG0833	amino acid
FTU_RS05685	COG0668	transmembrane transport
FTU_RS05695	COG0489	protein tyrosine kinase activity
FTU_RS05700	COG0477	Major facilitator Superfamily
FTU_RS05710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTU_RS05725	COG0523	cobalamin synthesis protein
FTU_RS05730	COG0735	belongs to the Fur family
FTU_RS05735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FTU_RS05735	COG0072	phenylalanine-tRNA ligase activity
FTU_RS05745	COG0697	spore germination
FTU_RS05750	COG3104	oligopeptide transport
FTU_RS05775	COG3655	Transcriptional regulator
FTU_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS05835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FTU_RS05840	COG0179	Fumarylacetoacetate (FAA) hydrolase
FTU_RS05845	COG1137	ATPase activity
FTU_RS05860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FTU_RS05865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FTU_RS05870	COG1686	Belongs to the peptidase S11 family
FTU_RS05875	COG2921	Belongs to the UPF0250 family
FTU_RS05905	COG0358	DNA primase activity
FTU_RS05910	COG1610	YqeY-like protein
FTU_RS05920	COG2027	D-alanyl-D-alanine carboxypeptidase
FTU_RS05945	COG0142	geranyltranstransferase activity
FTU_RS06005	COG1187	pseudouridine synthase activity
FTU_RS06120	COG1396	sequence-specific DNA binding
FTU_RS06125	COG3550	peptidyl-serine autophosphorylation
FTU_RS06165	COG2974	May be involved in recombination
FTU_RS06175	COG2996	Protein conserved in bacteria
FTU_RS06180	COG0210	DNA helicase
FTU_RS06185	COG0354	folic acid binding
FTU_RS06210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FTU_RS06215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FTU_RS06270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTU_RS06275	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FTU_RS06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTU_RS06305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FTU_RS06315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTU_RS06320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTU_RS06325	COG1862	Preprotein translocase
FTU_RS06330	COG1335	isochorismatase
FTU_RS06340	COG0583	DNA-binding transcription factor activity
FTU_RS06370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FTU_RS06375	COG1464	Belongs to the NlpA lipoprotein family
FTU_RS06380	COG0814	amino acid
FTU_RS06385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTU_RS06395	COG0189	ligase activity
FTU_RS06395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTU_RS06400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTU_RS06400	COG0189	ligase activity
FTU_RS06415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FTU_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS06500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FTU_RS06505	COG2814	Major facilitator Superfamily
FTU_RS06510	COG0531	amino acid
FTU_RS06520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FTU_RS06590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FTU_RS06595	COG0436	Aminotransferase
FTU_RS06605	COG1214	PFAM Peptidase M22, glycoprotease
FTU_RS06610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FTU_RS06615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FTU_RS06625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FTU_RS06630	COG1278	Cold shock
FTU_RS06680	COG0405	Gamma-glutamyltransferase
FTU_RS06690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTU_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTU_RS06695	COG2914	Belongs to the UPF0125 (RnfH) family
FTU_RS06700	COG2867	negative regulation of translational initiation
FTU_RS06735	COG1473	amidohydrolase
FTU_RS06755	COG0477	Major facilitator Superfamily
FTU_RS06770	COG0556	nucleotide-excision repair
FTU_RS06775	COG2925	Exonuclease
FTU_RS06780	COG4221	oxidoreductase activity
FTU_RS06835	COG0346	lactoylglutathione lyase activity
FTU_RS06840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FTU_RS06845	COG0561	phosphatase activity
FTU_RS06865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTU_RS06870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTU_RS06875	COG3079	Belongs to the UPF0149 family
FTU_RS06895	COG0586	Pfam SNARE associated Golgi protein
FTU_RS06900	COG0586	Pfam SNARE associated Golgi protein
FTU_RS06920	COG1530	ribonuclease E activity
FTU_RS06935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FTU_RS06950	COG3104	oligopeptide transport
FTU_RS06985	COG3028	Belongs to the UPF0307 family
FTU_RS07005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTU_RS07010	COG0564	pseudouridine synthase activity
FTU_RS07015	COG2992	FlgJ-related protein
FTU_RS07020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTU_RS07025	COG1127	ABC transporter
FTU_RS07045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FTU_RS07055	COG0318	PFAM AMP-dependent synthetase and ligase
FTU_RS07065	COG0477	Major facilitator Superfamily
FTU_RS07080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FTU_RS07125	COG0583	DNA-binding transcription factor activity
FTU_RS07145	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FTU_RS07160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FTU_RS07195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FTU_RS07215	COG0583	DNA-binding transcription factor activity
FTU_RS07230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FTU_RS07280	COG2271	Major facilitator Superfamily
FTU_RS07285	COG1739	Uncharacterized protein family UPF0029
FTU_RS07290	COG0009	L-threonylcarbamoyladenylate synthase
FTU_RS07295	COG2917	probably involved in intracellular septation
FTU_RS07305	COG0837	glucose binding
FTU_RS07320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FTU_RS07325	COG0537	adenosine 5'-monophosphoramidase activity
FTU_RS07340	COG2226	methyltransferase
FTU_RS07350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FTU_RS07355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FTU_RS07385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FTU_RS07395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FTU_RS07420	COG0516	GMP reductase activity
FTU_RS07420	COG0517	IMP dehydrogenase activity
FTU_RS07430	COG0795	lipopolysaccharide-transporting ATPase activity
FTU_RS07435	COG0795	lipopolysaccharide-transporting ATPase activity
FTU_RS07450	COG0742	ribosomal rna small subunit methyltransferase
FTU_RS07455	COG2860	membrane
FTU_RS07465	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FTU_RS07470	COG0295	cytidine deaminase activity
FTU_RS07480	COG0277	FAD linked oxidase domain protein
FTU_RS07480	COG0247	lactate metabolic process
FTU_RS07495	COG1940	carbohydrate kinase activity
FTU_RS07515	COG4988	ABC transporter
FTU_RS07520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FTU_RS07530	COG0251	oxidation-reduction process
FTU_RS07535	COG0659	secondary active sulfate transmembrane transporter activity
FTU_RS07545	COG1994	Peptidase M50
FTU_RS07675	COG0738	Major facilitator superfamily
FTU_RS07695	COG0191	fructose-bisphosphate aldolase activity
FTU_RS07700	COG0469	pyruvate kinase activity
FTU_RS07740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FTU_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
FTU_RS07750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FTU_RS07755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FTU_RS07765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTU_RS07765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTU_RS07780	COG0483	inositol monophosphate 1-phosphatase activity
FTU_RS07785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FTU_RS07785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FTU_RS07840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTU_RS07845	COG1074	ATP-dependent DNA helicase activity
FTU_RS07860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FTU_RS07870	COG0697	spore germination
FTU_RS07935	COG2166	iron-sulfur cluster assembly
FTU_RS07965	COG0436	Aminotransferase
FTU_RS08005	COG2983	Belongs to the UPF0260 family
FTU_RS08025	COG0446	pyridine nucleotide-disulphide oxidoreductase
FTU_RS08030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTU_RS08060	COG1280	lysine exporter protein (LysE YggA)
FTU_RS08070	COG0463	Glycosyl transferase, family 2
FTU_RS08075	COG0842	Transport permease protein
FTU_RS08080	COG1131	(ABC) transporter
FTU_RS08100	COG0084	hydrolase, TatD family'
FTU_RS08130	COG0248	Ppx GppA phosphatase
FTU_RS08135	COG3118	belongs to the thioredoxin family
FTU_RS08150	COG0662	Cupin 2, conserved barrel domain protein
FTU_RS08150	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FTU_RS08160	COG1088	dTDP-glucose 4,6-dehydratase activity
FTU_RS08170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FTU_RS08195	COG0367	asparagine synthase
FTU_RS08210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FTU_RS08235	COG1086	Polysaccharide biosynthesis protein
FTU_RS08250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FTU_RS08260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FTU_RS08270	COG0513	Belongs to the DEAD box helicase family
FTU_RS08275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTU_RS08280	COG2814	Major facilitator Superfamily
FTU_RS08285	COG2814	Major facilitator Superfamily
FTU_RS08290	COG1085	galactose-1-phosphate uridylyltransferase
FTU_RS08325	COG3676	manually curated
FTU_RS08330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTU_RS08335	COG0508	dehydrogenase complex catalyzes the overall conversion of
FTU_RS08350	COG0237	dephospho-CoA kinase activity
FTU_RS08365	COG0180	Tryptophanyl-tRNA synthetase
FTU_RS08390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FTU_RS08430	COG0814	amino acid
FTU_RS08435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FTU_RS08460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTU_RS08475	COG0814	amino acid
FTU_RS08490	COG0531	amino acid
FTU_RS08500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTU_RS08510	COG0398	Pfam SNARE associated Golgi protein
FTU_RS08515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FTU_RS08525	COG0531	amino acid
FTU_RS08545	COG1643	Atp-dependent helicase
FTU_RS08560	COG1393	Belongs to the ArsC family
FTU_RS08565	COG0318	PFAM AMP-dependent synthetase and ligase
FTU_RS08570	COG1960	acyl-CoA dehydrogenase activity
FTU_RS08575	COG1024	Enoyl-CoA hydratase
FTU_RS08575	COG1250	3-hydroxyacyl-CoA dehydrogenase
FTU_RS08580	COG0183	Belongs to the thiolase family
FTU_RS08645	COG0745	RESPONSE REGULATOR receiver
FTU_RS08665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FTU_RS08705	COG0557	exoribonuclease II activity
FTU_RS08720	COG0681	Belongs to the peptidase S26 family
FTU_RS08735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FTU_RS08740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FTU_RS08745	COG1519	Transferase
FTU_RS08750	COG0142	geranyltranstransferase activity
FTU_RS08755	COG1183	phosphatidylcholine synthase activity
FTU_RS08770	COG1472	Belongs to the glycosyl hydrolase 3 family
FTU_RS08790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FTU_RS08810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTU_RS08890	COG0531	amino acid
FTU_RS08905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FTU_RS08910	COG2853	Lipoprotein
FTU_RS08920	COG0583	DNA-binding transcription factor activity
FTU_RS08945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FTU_RS08955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FTU_RS08975	COG0850	regulation of cytokinetic process
FTU_RS08990	COG1127	ABC transporter
FTU_RS08995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTU_RS09000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FTU_RS09040	COG2890	protein-(glutamine-N5) methyltransferase activity
FTU_RS09095	COG1253	flavin adenine dinucleotide binding
FTU_RS09105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FTU_RS09110	COG1494	fructose-1,6-bisphosphatase
FTU_RS09115	COG2945	thiolester hydrolase activity
FTU_RS09120	COG0833	amino acid
FTU_RS09130	COG1674	ftsk spoiiie
FTU_RS09145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FTU_RS09170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FTU_RS09185	COG1621	beta-fructofuranosidase activity
FTU_RS09205	COG0284	orotidine-5'-phosphate decarboxylase activity
FTU_RS09225	COG0583	DNA-binding transcription factor activity
FTU_RS09235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTU_RS09280	COG0505	Belongs to the CarA family
FTU_RS09285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FTU_RS09290	COG0540	Belongs to the ATCase OTCase family
FTU_RS09295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FTU_RS09305	COG0814	amino acid
FTU_RS09330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTU_RS09330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTU_RS09340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTU_RS09340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTU_RS09350	COG0242	peptide deformylase activity
FTU_RS09375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTU_RS09380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FTU_RS09390	COG2814	Major facilitator Superfamily
FTU_RS09415	COG0814	amino acid
FTU_RS09425	COG0778	Nitroreductase
FTU_RS09605	COG0738	Major facilitator superfamily
FTU_RS09625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FTU_RS09625	COG0047	phosphoribosylformylglycinamidine synthase activity
FTU_RS09630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FTU_RS09635	COG0076	glutamate decarboxylase activity
FTU_RS09645	COG1538	Outer membrane efflux protein
FTU_RS09655	COG0826	peptidase U32
FTU_RS09665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FTU_RS09675	COG0531	amino acid
FTU_RS09685	COG0814	amino acid
FTU_RS09710	COG2205	protein histidine kinase activity
FTU_RS09715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FTU_RS09745	COG3961	Belongs to the TPP enzyme family
FTU_RS09765	COG0425	Belongs to the sulfur carrier protein TusA family
FTU_RS09765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTU_RS09780	COG2137	regulation of response to DNA damage stimulus
FTU_RS09785	COG0629	single-stranded DNA binding
FTU_RS09795	COG0857	belongs to the CobB CobQ family
FTU_RS09795	COG0280	phosphate acetyltransferase
FTU_RS09835	COG0204	Acyl-transferase
FTU_RS09845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FTU_RS09875	COG0542	response to heat
FTU_RS09900	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FTU_RS09940	COG0488	(ABC) transporter
FTU_RS09995	COG0308	aminopeptidase N
FTU_RS10000	COG0071	Belongs to the small heat shock protein (HSP20) family
FTU_RS10005	COG0134	indole-3-glycerol-phosphate synthase activity
FTU_RS10005	COG0135	phosphoribosylanthranilate isomerase activity
FTU_RS10015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTU_RS10045	COG0512	Glutamine amidotransferase of anthranilate synthase
FTU_RS10050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia