locus-tag	class	description
FTW_RS00015	COG0477	Major facilitator Superfamily
FTW_RS00050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FTW_RS00075	COG0542	response to heat
FTW_RS00100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FTW_RS00110	COG0204	Acyl-transferase
FTW_RS00145	COG3335	DDE superfamily endonuclease
FTW_RS00150	COG0738	Major facilitator superfamily
FTW_RS00280	COG3335	DDE superfamily endonuclease
FTW_RS00300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FTW_RS00305	COG2205	protein histidine kinase activity
FTW_RS00325	COG0814	amino acid
FTW_RS00335	COG0531	amino acid
FTW_RS00345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FTW_RS00355	COG0826	peptidase U32
FTW_RS00365	COG1538	Outer membrane efflux protein
FTW_RS00375	COG0076	glutamate decarboxylase activity
FTW_RS00380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FTW_RS00385	COG0047	phosphoribosylformylglycinamidine synthase activity
FTW_RS00385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FTW_RS00400	COG3335	DDE superfamily endonuclease
FTW_RS00435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FTW_RS00455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FTW_RS00490	COG2814	Major facilitator Superfamily
FTW_RS00495	COG0019	diaminopimelate decarboxylase activity
FTW_RS00500	COG2814	Major facilitator Superfamily
FTW_RS00505	COG4264	IucA IucC family
FTW_RS00515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FTW_RS00535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FTW_RS00545	COG1034	ATP synthesis coupled electron transport
FTW_RS00560	COG0839	Belongs to the complex I subunit 6 family
FTW_RS00610	COG0195	Participates in both transcription termination and antitermination
FTW_RS00610	COG2251	uridine kinase activity
FTW_RS00635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FTW_RS00640	COG0564	pseudouridine synthase activity
FTW_RS00700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FTW_RS00715	COG2223	nitrite transmembrane transporter activity
FTW_RS00730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FTW_RS00735	COG1053	succinate dehydrogenase
FTW_RS00740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FTW_RS00770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FTW_RS00795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FTW_RS00825	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FTW_RS00840	COG1271	oxidase subunit
FTW_RS00850	COG1090	epimerase
FTW_RS00880	COG3335	DDE superfamily endonuclease
FTW_RS00900	COG1619	proteins homologs of microcin C7 resistance protein MccF
FTW_RS00920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FTW_RS00925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTW_RS00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTW_RS00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTW_RS00960	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FTW_RS00965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FTW_RS00970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTW_RS00975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTW_RS00995	COG0552	protein localization to endoplasmic reticulum
FTW_RS01000	COG0210	DNA helicase
FTW_RS01005	COG4166	transmembrane transport
FTW_RS01020	COG0444	Belongs to the ABC transporter superfamily
FTW_RS01025	COG4608	Belongs to the ABC transporter superfamily
FTW_RS01030	COG2814	Major facilitator Superfamily
FTW_RS01050	COG3335	DDE superfamily endonuclease
FTW_RS01065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FTW_RS01080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTW_RS01110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FTW_RS01190	COG4974	Belongs to the 'phage' integrase family
FTW_RS01235	COG3023	N-Acetylmuramoyl-L-alanine amidase
FTW_RS01245	COG2814	Major facilitator Superfamily
FTW_RS01250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTW_RS01270	COG2890	protein-(glutamine-N5) methyltransferase activity
FTW_RS01285	COG3335	DDE superfamily endonuclease
FTW_RS01315	COG3335	DDE superfamily endonuclease
FTW_RS01325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FTW_RS01350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FTW_RS01365	COG1674	ftsk spoiiie
FTW_RS01375	COG0833	amino acid
FTW_RS01380	COG2945	thiolester hydrolase activity
FTW_RS01385	COG1494	fructose-1,6-bisphosphatase
FTW_RS01390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FTW_RS01400	COG1253	flavin adenine dinucleotide binding
FTW_RS01445	COG3335	DDE superfamily endonuclease
FTW_RS01455	COG0456	acetyltransferase
FTW_RS01465	COG2890	protein-(glutamine-N5) methyltransferase activity
FTW_RS01480	COG3335	DDE superfamily endonuclease
FTW_RS01505	COG0531	amino acid
FTW_RS01520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FTW_RS01525	COG2853	Lipoprotein
FTW_RS01535	COG0583	DNA-binding transcription factor activity
FTW_RS01555	COG3335	DDE superfamily endonuclease
FTW_RS01585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FTW_RS01590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTW_RS01595	COG1127	ABC transporter
FTW_RS01610	COG0850	regulation of cytokinetic process
FTW_RS01630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FTW_RS01640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FTW_RS01650	COG3335	DDE superfamily endonuclease
FTW_RS01655	COG3676	manually curated
FTW_RS01720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTW_RS01740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FTW_RS01775	COG1183	phosphatidylcholine synthase activity
FTW_RS01780	COG0142	geranyltranstransferase activity
FTW_RS01785	COG1519	Transferase
FTW_RS01790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FTW_RS01795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FTW_RS01800	COG2828	Protein conserved in bacteria
FTW_RS01810	COG0681	Belongs to the peptidase S26 family
FTW_RS01825	COG0557	exoribonuclease II activity
FTW_RS01855	COG3335	DDE superfamily endonuclease
FTW_RS01865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FTW_RS01885	COG0745	RESPONSE REGULATOR receiver
FTW_RS01955	COG0183	Belongs to the thiolase family
FTW_RS01960	COG1024	Enoyl-CoA hydratase
FTW_RS01960	COG1250	3-hydroxyacyl-CoA dehydrogenase
FTW_RS01965	COG1960	acyl-CoA dehydrogenase activity
FTW_RS01970	COG0318	PFAM AMP-dependent synthetase and ligase
FTW_RS01975	COG1393	Belongs to the ArsC family
FTW_RS01990	COG1643	Atp-dependent helicase
FTW_RS01995	COG1643	Atp-dependent helicase
FTW_RS02005	COG1086	Polysaccharide biosynthesis protein
FTW_RS02030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FTW_RS02045	COG0367	asparagine synthase
FTW_RS02065	COG1215	transferase activity, transferring glycosyl groups
FTW_RS02070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FTW_RS02080	COG1088	dTDP-glucose 4,6-dehydratase activity
FTW_RS02090	COG3335	DDE superfamily endonuclease
FTW_RS02110	COG1280	lysine exporter protein (LysE YggA)
FTW_RS02120	COG0463	Glycosyl transferase, family 2
FTW_RS02125	COG0842	Transport permease protein
FTW_RS02130	COG1131	(ABC) transporter
FTW_RS02140	COG0730	response to heat
FTW_RS02150	COG0084	hydrolase, TatD family'
FTW_RS02175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FTW_RS02185	COG0248	Ppx GppA phosphatase
FTW_RS02190	COG3118	belongs to the thioredoxin family
FTW_RS02205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FTW_RS02205	COG0662	Cupin 2, conserved barrel domain protein
FTW_RS02210	COG3335	DDE superfamily endonuclease
FTW_RS02225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTW_RS02250	COG2983	Belongs to the UPF0260 family
FTW_RS02290	COG0436	Aminotransferase
FTW_RS02320	COG2166	iron-sulfur cluster assembly
FTW_RS02390	COG0069	glutamate synthase activity
FTW_RS02395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FTW_RS02410	COG1074	ATP-dependent DNA helicase activity
FTW_RS02415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTW_RS02450	COG3335	DDE superfamily endonuclease
FTW_RS02470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FTW_RS02470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FTW_RS02475	COG0483	inositol monophosphate 1-phosphatase activity
FTW_RS02480	COG2855	membrane
FTW_RS02495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTW_RS02495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTW_RS02505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FTW_RS02510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FTW_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS02520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FTW_RS02560	COG0469	pyruvate kinase activity
FTW_RS02565	COG0191	fructose-bisphosphate aldolase activity
FTW_RS02590	COG3335	DDE superfamily endonuclease
FTW_RS02595	COG0738	Major facilitator superfamily
FTW_RS02715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FTW_RS02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FTW_RS02730	COG0583	DNA-binding transcription factor activity
FTW_RS02750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FTW_RS02785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FTW_RS02800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FTW_RS02820	COG0583	DNA-binding transcription factor activity
FTW_RS02835	COG3335	DDE superfamily endonuclease
FTW_RS02845	COG1611	Belongs to the LOG family
FTW_RS02865	COG3220	belongs to the UPF0276 family
FTW_RS02880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FTW_RS02880	COG0517	IMP dehydrogenase activity
FTW_RS02885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FTW_RS02890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FTW_RS02895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FTW_RS02905	COG1132	(ABC) transporter
FTW_RS02920	COG3475	LICD family
FTW_RS02925	COG1442	glycosyl transferase family 8
FTW_RS02925	COG1216	Glycosyl transferase, family 2
FTW_RS02930	COG1216	Glycosyl transferase, family 2
FTW_RS02930	COG1442	glycosyl transferase family 8
FTW_RS02935	COG0438	transferase activity, transferring glycosyl groups
FTW_RS02955	COG1446	asparaginase
FTW_RS02985	COG0477	Major facilitator Superfamily
FTW_RS03005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTW_RS03025	COG0509	glycine decarboxylation via glycine cleavage system
FTW_RS03035	COG3397	chitin binding
FTW_RS03070	COG3335	DDE superfamily endonuclease
FTW_RS03100	COG1085	galactose-1-phosphate uridylyltransferase
FTW_RS03105	COG2814	Major facilitator Superfamily
FTW_RS03110	COG2814	Major facilitator Superfamily
FTW_RS03115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTW_RS03120	COG0513	Belongs to the DEAD box helicase family
FTW_RS03130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FTW_RS03140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FTW_RS03170	COG0386	Belongs to the glutathione peroxidase family
FTW_RS03205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FTW_RS03205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FTW_RS03210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FTW_RS03255	COG1566	PFAM secretion protein HlyD family protein
FTW_RS03275	COG1509	lysine 2,3-aminomutase activity
FTW_RS03280	COG1278	Cold shock
FTW_RS03305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FTW_RS03310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FTW_RS03315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FTW_RS03320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FTW_RS03345	COG0084	hydrolase, TatD family'
FTW_RS03350	COG0751	glycine-tRNA ligase activity
FTW_RS03360	COG3335	DDE superfamily endonuclease
FTW_RS03375	COG3335	DDE superfamily endonuclease
FTW_RS03390	COG0655	NAD(P)H dehydrogenase (quinone) activity
FTW_RS03400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FTW_RS03415	COG0477	Major facilitator Superfamily
FTW_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
FTW_RS03435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FTW_RS03455	COG1127	ABC transporter
FTW_RS03460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTW_RS03465	COG2992	FlgJ-related protein
FTW_RS03470	COG0564	pseudouridine synthase activity
FTW_RS03475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTW_RS03495	COG3028	Belongs to the UPF0307 family
FTW_RS03535	COG3335	DDE superfamily endonuclease
FTW_RS03550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FTW_RS03565	COG1530	ribonuclease E activity
FTW_RS03585	COG0586	Pfam SNARE associated Golgi protein
FTW_RS03590	COG0586	Pfam SNARE associated Golgi protein
FTW_RS03605	COG3079	Belongs to the UPF0149 family
FTW_RS03610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTW_RS03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTW_RS03630	COG0561	phosphatase activity
FTW_RS03635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FTW_RS03640	COG0346	lactoylglutathione lyase activity
FTW_RS03655	COG3335	DDE superfamily endonuclease
FTW_RS03675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FTW_RS03680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FTW_RS03690	COG2226	methyltransferase
FTW_RS03700	COG1040	competence protein
FTW_RS03710	COG0537	adenosine 5'-monophosphoramidase activity
FTW_RS03715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FTW_RS03730	COG0837	glucose binding
FTW_RS03740	COG2917	probably involved in intracellular septation
FTW_RS03745	COG0009	L-threonylcarbamoyladenylate synthase
FTW_RS03750	COG1739	Uncharacterized protein family UPF0029
FTW_RS03755	COG2271	Major facilitator Superfamily
FTW_RS03815	COG1994	Peptidase M50
FTW_RS03825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FTW_RS03845	COG0531	amino acid
FTW_RS03855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FTW_RS03860	COG0398	Pfam SNARE associated Golgi protein
FTW_RS03865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTW_RS03870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTW_RS03880	COG0531	amino acid
FTW_RS03895	COG0814	amino acid
FTW_RS03905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTW_RS03930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FTW_RS03935	COG0814	amino acid
FTW_RS03975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FTW_RS04005	COG0180	Tryptophanyl-tRNA synthetase
FTW_RS04020	COG0237	dephospho-CoA kinase activity
FTW_RS04035	COG0508	dehydrogenase complex catalyzes the overall conversion of
FTW_RS04040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTW_RS04050	COG3335	DDE superfamily endonuclease
FTW_RS04095	COG0189	ligase activity
FTW_RS04105	COG1472	Belongs to the glycosyl hydrolase 3 family
FTW_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS04150	COG0156	8-amino-7-oxononanoate synthase activity
FTW_RS04160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FTW_RS04165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FTW_RS04180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FTW_RS04180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FTW_RS04185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FTW_RS04195	COG0512	Glutamine amidotransferase of anthranilate synthase
FTW_RS04195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FTW_RS04200	COG0512	Glutamine amidotransferase of anthranilate synthase
FTW_RS04200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FTW_RS04225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FTW_RS04245	COG0302	gtp cyclohydrolase
FTW_RS04250	COG0513	Belongs to the DEAD box helicase family
FTW_RS04255	COG3104	oligopeptide transport
FTW_RS04265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTW_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS04285	COG0708	Exodeoxyribonuclease III
FTW_RS04295	COG2249	NAD(P)H dehydrogenase (quinone) activity
FTW_RS04305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FTW_RS04310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FTW_RS04340	COG0531	amino acid
FTW_RS04345	COG0569	domain protein
FTW_RS04355	COG0719	Fe-S assembly protein
FTW_RS04360	COG0396	ATPase activity
FTW_RS04365	COG0719	Fe-S assembly protein
FTW_RS04405	COG0833	amino acid
FTW_RS04475	COG0668	transmembrane transport
FTW_RS04485	COG0489	protein tyrosine kinase activity
FTW_RS04490	COG0477	Major facilitator Superfamily
FTW_RS04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTW_RS04515	COG0523	cobalamin synthesis protein
FTW_RS04520	COG0735	belongs to the Fur family
FTW_RS04525	COG0072	phenylalanine-tRNA ligase activity
FTW_RS04525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FTW_RS04535	COG0697	spore germination
FTW_RS04540	COG3104	oligopeptide transport
FTW_RS04560	COG3655	Transcriptional regulator
FTW_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS04620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FTW_RS04625	COG0179	Fumarylacetoacetate (FAA) hydrolase
FTW_RS04630	COG1137	ATPase activity
FTW_RS04645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FTW_RS04650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FTW_RS04655	COG1686	Belongs to the peptidase S11 family
FTW_RS04660	COG2921	Belongs to the UPF0250 family
FTW_RS04695	COG0358	DNA primase activity
FTW_RS04700	COG1610	YqeY-like protein
FTW_RS04710	COG2027	D-alanyl-D-alanine carboxypeptidase
FTW_RS04735	COG0142	geranyltranstransferase activity
FTW_RS04760	COG0529	Catalyzes the synthesis of activated sulfate
FTW_RS04795	COG1187	pseudouridine synthase activity
FTW_RS04845	COG3335	DDE superfamily endonuclease
FTW_RS04875	COG0583	DNA-binding transcription factor activity
FTW_RS04885	COG1937	Protein conserved in bacteria
FTW_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
FTW_RS04910	COG1876	peptidase activity
FTW_RS04935	COG2824	Alkylphosphonate utilization operon protein PhnA
FTW_RS04960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FTW_RS04990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FTW_RS05000	COG0488	(ABC) transporter
FTW_RS05025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FTW_RS05030	COG2852	Protein conserved in bacteria
FTW_RS05050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTW_RS05055	COG2264	protein methyltransferase activity
FTW_RS05070	COG0277	FAD linked oxidase domain protein
FTW_RS05075	COG3961	Belongs to the TPP enzyme family
FTW_RS05090	COG3335	DDE superfamily endonuclease
FTW_RS05100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FTW_RS05105	COG0095	Lipoate-protein ligase
FTW_RS05115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FTW_RS05125	COG3104	oligopeptide transport
FTW_RS05140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FTW_RS05160	COG0012	GTP binding
FTW_RS05170	COG2226	methyltransferase
FTW_RS05175	COG4536	flavin adenine dinucleotide binding
FTW_RS05185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FTW_RS05240	COG0076	glutamate decarboxylase activity
FTW_RS05265	COG1322	Protein conserved in bacteria
FTW_RS05275	COG2271	Major facilitator Superfamily
FTW_RS05290	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FTW_RS05305	COG3104	oligopeptide transport
FTW_RS05310	COG2999	glutathione oxidoreductase activity
FTW_RS05315	COG2878	Part of a membrane complex involved in electron transport
FTW_RS05320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FTW_RS05335	COG0670	Belongs to the BI1 family
FTW_RS05340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FTW_RS05345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FTW_RS05365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FTW_RS05385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FTW_RS05390	COG0330	HflC and HflK could
FTW_RS05395	COG0330	HflC and HflK could
FTW_RS05405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FTW_RS05430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FTW_RS05435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FTW_RS05465	COG4122	O-methyltransferase activity
FTW_RS05475	COG1702	phosphate starvation-inducible protein PhoH
FTW_RS05485	COG4535	Mg2 and Co2 transporter CorC
FTW_RS05490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FTW_RS05520	COG1496	oxidoreductase activity
FTW_RS05570	COG2814	Major facilitator Superfamily
FTW_RS05575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTW_RS05580	COG1823	symporter activity
FTW_RS05595	COG1773	rubredoxin
FTW_RS05600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FTW_RS05610	COG0288	reversible hydration of carbon dioxide
FTW_RS05615	COG0252	asparaginase activity
FTW_RS05640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FTW_RS05650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTW_RS05655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTW_RS05660	COG1862	Preprotein translocase
FTW_RS05670	COG1335	isochorismatase
FTW_RS05680	COG0583	DNA-binding transcription factor activity
FTW_RS05710	COG1464	Belongs to the NlpA lipoprotein family
FTW_RS05715	COG0814	amino acid
FTW_RS05720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTW_RS05730	COG0189	ligase activity
FTW_RS05730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTW_RS05735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTW_RS05735	COG0189	ligase activity
FTW_RS05750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FTW_RS05780	COG0415	Belongs to the DNA photolyase family
FTW_RS05790	COG3335	DDE superfamily endonuclease
FTW_RS05825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FTW_RS05830	COG2814	Major facilitator Superfamily
FTW_RS05835	COG0531	amino acid
FTW_RS05845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FTW_RS05915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FTW_RS05920	COG0436	Aminotransferase
FTW_RS05930	COG1214	PFAM Peptidase M22, glycoprotease
FTW_RS05935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FTW_RS05940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FTW_RS05950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FTW_RS05955	COG1278	Cold shock
FTW_RS06000	COG0405	Gamma-glutamyltransferase
FTW_RS06010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTW_RS06010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTW_RS06015	COG2914	Belongs to the UPF0125 (RnfH) family
FTW_RS06020	COG2867	negative regulation of translational initiation
FTW_RS06040	COG0477	Major facilitator Superfamily
FTW_RS06055	COG1473	amidohydrolase
FTW_RS06065	COG2308	Evidence 4 Homologs of previously reported genes of
FTW_RS06070	COG0477	Major facilitator Superfamily
FTW_RS06085	COG0556	nucleotide-excision repair
FTW_RS06090	COG2925	Exonuclease
FTW_RS06095	COG4221	oxidoreductase activity
FTW_RS06140	COG3335	DDE superfamily endonuclease
FTW_RS06160	COG0281	malic enzyme
FTW_RS06165	COG0196	riboflavin kinase activity
FTW_RS06200	COG0519	Catalyzes the synthesis of GMP from XMP
FTW_RS06205	COG1475	DNA binding
FTW_RS06210	COG1192	Involved in chromosome partitioning
FTW_RS06250	COG0339	signal peptide processing
FTW_RS06270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FTW_RS06280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FTW_RS06290	COG0671	phosphoesterase, PA-phosphatase related
FTW_RS06295	COG4969	Belongs to the N-Me-Phe pilin family
FTW_RS06310	COG0497	DNA recombination
FTW_RS06320	COG0436	Aminotransferase
FTW_RS06335	COG0833	amino acid
FTW_RS06350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTW_RS06350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTW_RS06430	COG1704	LemA family
FTW_RS06475	COG2363	Small membrane protein
FTW_RS06480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FTW_RS06505	COG0385	Bile acid
FTW_RS06520	COG0415	Belongs to the DNA photolyase family
FTW_RS06565	COG0811	peptide transport
FTW_RS06575	COG1183	phosphatidylcholine synthase activity
FTW_RS06580	COG4401	Chorismate mutase type I
FTW_RS06600	COG0758	DNA mediated transformation
FTW_RS06605	COG2985	domain, Protein
FTW_RS06635	COG1051	belongs to the nudix hydrolase family
FTW_RS06640	COG3335	DDE superfamily endonuclease
FTW_RS06705	COG3335	DDE superfamily endonuclease
FTW_RS06715	COG1396	sequence-specific DNA binding
FTW_RS06760	COG2974	May be involved in recombination
FTW_RS06770	COG2996	Protein conserved in bacteria
FTW_RS06775	COG0210	DNA helicase
FTW_RS06780	COG0354	folic acid binding
FTW_RS06805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FTW_RS06810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FTW_RS06830	COG0210	DNA helicase
FTW_RS06865	COG2814	Major facilitator Superfamily
FTW_RS06870	COG2814	Major facilitator Superfamily
FTW_RS06875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTW_RS06880	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FTW_RS06890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTW_RS06940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FTW_RS06950	COG2151	metal-sulfur cluster biosynthetic enzyme
FTW_RS06955	COG0316	Belongs to the HesB IscA family
FTW_RS06960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FTW_RS06965	COG1760	l-serine dehydratase
FTW_RS06975	COG0077	Prephenate dehydratase
FTW_RS06975	COG1605	Chorismate mutase
FTW_RS06990	COG3104	oligopeptide transport
FTW_RS07010	COG0560	Phosphoserine phosphatase
FTW_RS07035	COG3335	DDE superfamily endonuclease
FTW_RS07040	COG3842	ATPase activity
FTW_RS07045	COG1176	ABC-type spermidine putrescine transport system, permease component I
FTW_RS07050	COG1177	transmembrane transport
FTW_RS07065	COG3335	DDE superfamily endonuclease
FTW_RS07085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FTW_RS07090	COG2814	Major facilitator Superfamily
FTW_RS07135	COG0813	purine-nucleoside phosphorylase activity
FTW_RS07140	COG3335	DDE superfamily endonuclease
FTW_RS07150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FTW_RS07160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FTW_RS07185	COG0516	GMP reductase activity
FTW_RS07185	COG0517	IMP dehydrogenase activity
FTW_RS07195	COG0795	lipopolysaccharide-transporting ATPase activity
FTW_RS07200	COG0795	lipopolysaccharide-transporting ATPase activity
FTW_RS07215	COG0742	ribosomal rna small subunit methyltransferase
FTW_RS07220	COG2860	membrane
FTW_RS07230	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FTW_RS07235	COG0295	cytidine deaminase activity
FTW_RS07245	COG0247	lactate metabolic process
FTW_RS07245	COG0277	FAD linked oxidase domain protein
FTW_RS07260	COG1940	carbohydrate kinase activity
FTW_RS07280	COG4988	ABC transporter
FTW_RS07285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FTW_RS07295	COG0251	oxidation-reduction process
FTW_RS07300	COG0659	secondary active sulfate transmembrane transporter activity
FTW_RS07310	COG0842	Transport permease protein
FTW_RS07315	COG1131	(ABC) transporter
FTW_RS07325	COG0584	glycerophosphoryl diester phosphodiesterase
FTW_RS07330	COG2271	Major facilitator Superfamily
FTW_RS07335	COG1686	Belongs to the peptidase S11 family
FTW_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
FTW_RS07350	COG3335	DDE superfamily endonuclease
FTW_RS07360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FTW_RS07390	COG0156	8-amino-7-oxononanoate synthase activity
FTW_RS07400	COG0814	amino acid
FTW_RS07405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FTW_RS07410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FTW_RS07435	COG1940	carbohydrate kinase activity
FTW_RS07495	COG3116	cell division
FTW_RS07505	COG0204	Acyl-transferase
FTW_RS07505	COG0318	PFAM AMP-dependent synthetase and ligase
FTW_RS07510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FTW_RS07520	COG3335	DDE superfamily endonuclease
FTW_RS07545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTW_RS07575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FTW_RS07585	COG0628	permease
FTW_RS07625	COG0583	DNA-binding transcription factor activity
FTW_RS07630	COG0546	phosphoglycolate phosphatase activity
FTW_RS07635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTW_RS07640	COG0492	ferredoxin-NADP+ reductase activity
FTW_RS07660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FTW_RS07675	COG1162	GTPase activity
FTW_RS07690	COG0531	amino acid
FTW_RS07700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FTW_RS07705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FTW_RS07705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FTW_RS07725	COG0439	Biotin carboxylase
FTW_RS07730	COG0511	ligase activity, forming carbon-carbon bonds
FTW_RS07740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FTW_RS07750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTW_RS07770	COG0252	asparaginase activity
FTW_RS07775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FTW_RS07780	COG0113	porphobilinogen synthase activity
FTW_RS07790	COG0470	DNA polymerase III
FTW_RS07795	COG0616	signal peptide processing
FTW_RS07800	COG0625	glutathione transferase activity
FTW_RS07805	COG2920	part of a sulfur-relay system
FTW_RS07815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FTW_RS07820	COG0463	Glycosyl transferase, family 2
FTW_RS07830	COG0772	Belongs to the SEDS family
FTW_RS07845	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FTW_RS07850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FTW_RS07865	COG0488	(ABC) transporter
FTW_RS07880	COG2814	Major facilitator Superfamily
FTW_RS07900	COG3335	DDE superfamily endonuclease
FTW_RS07905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTW_RS07910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FTW_RS07915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FTW_RS07950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FTW_RS07955	COG1874	Beta-galactosidase
FTW_RS07960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FTW_RS07965	COG0083	homoserine kinase activity
FTW_RS07970	COG0527	aspartate kinase activity
FTW_RS07970	COG0460	homoserine dehydrogenase
FTW_RS07975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FTW_RS07985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FTW_RS07995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTW_RS08005	COG1640	4-alpha-glucanotransferase
FTW_RS08010	COG0058	SHG alpha-glucan phosphorylase activity
FTW_RS08025	COG0033	Phosphoglucomutase
FTW_RS08035	COG1523	belongs to the glycosyl hydrolase 13 family
FTW_RS08055	COG0509	glycine decarboxylation via glycine cleavage system
FTW_RS08065	COG1982	Orn Lys Arg decarboxylase major
FTW_RS08085	COG0242	peptide deformylase activity
FTW_RS08090	COG0587	DNA-directed DNA polymerase activity
FTW_RS08100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FTW_RS08115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FTW_RS08120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FTW_RS08135	COG0024	Methionine aminopeptidase
FTW_RS08160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTW_RS08170	COG1051	belongs to the nudix hydrolase family
FTW_RS08170	COG1056	cytidyltransferase-related domain
FTW_RS08210	COG3335	DDE superfamily endonuclease
FTW_RS08235	COG2918	glutathione biosynthetic process
FTW_RS08240	COG0728	peptidoglycan biosynthetic process
FTW_RS08250	COG0802	atpase or kinase
FTW_RS08255	COG0285	dihydrofolate synthase activity
FTW_RS08260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FTW_RS08295	COG3335	DDE superfamily endonuclease
FTW_RS08310	COG3335	DDE superfamily endonuclease
FTW_RS08330	COG0300	oxidoreductase activity
FTW_RS08340	COG2081	HI0933 family
FTW_RS08350	COG3335	DDE superfamily endonuclease
FTW_RS08365	COG3335	DDE superfamily endonuclease
FTW_RS08380	COG3335	DDE superfamily endonuclease
FTW_RS08420	COG0201	protein transport
FTW_RS08545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTW_RS08555	COG0575	Belongs to the CDS family
FTW_RS08560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FTW_RS08585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FTW_RS08620	COG0114	fumarate hydratase activity
FTW_RS08635	COG1304	FMN binding
FTW_RS08655	COG0525	valine-tRNA ligase activity
FTW_RS08670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FTW_RS08685	COG2304	oxidoreductase activity
FTW_RS08705	COG0714	Associated with various cellular activities
FTW_RS08715	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FTW_RS08735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FTW_RS08745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FTW_RS08750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FTW_RS08755	COG2814	Major facilitator Superfamily
FTW_RS08760	COG1271	oxidase subunit
FTW_RS08765	COG1294	oxidase, subunit
FTW_RS08775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FTW_RS08780	COG2814	Major facilitator Superfamily
FTW_RS08790	COG3335	DDE superfamily endonuclease
FTW_RS08815	COG0557	exoribonuclease II activity
FTW_RS08855	COG1116	anion transmembrane transporter activity
FTW_RS08870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FTW_RS08900	COG3335	DDE superfamily endonuclease
FTW_RS08930	COG3511	phospholipase C
FTW_RS08935	COG1984	allophanate hydrolase subunit 2
FTW_RS08955	COG3335	DDE superfamily endonuclease
FTW_RS08970	COG0589	response to stress
FTW_RS08995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FTW_RS09005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FTW_RS09020	COG0594	ribonuclease P activity
FTW_RS09035	COG1560	Kdo2-lipid A biosynthetic process
FTW_RS09040	COG1560	Kdo2-lipid A biosynthetic process
FTW_RS09070	COG3335	DDE superfamily endonuclease
FTW_RS09080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FTW_RS09085	COG0574	Belongs to the PEP-utilizing enzyme family
FTW_RS09085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FTW_RS09095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FTW_RS09100	COG3335	DDE superfamily endonuclease
FTW_RS09110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FTW_RS09120	COG1295	ribonuclease BN
FTW_RS09145	COG1121	(ABC) transporter
FTW_RS09170	COG0138	bifunctional purine biosynthesis protein purh
FTW_RS09185	COG0814	amino acid
FTW_RS09195	COG3040	lipid binding
FTW_RS09210	COG2066	Belongs to the glutaminase family
FTW_RS09220	COG2862	Uncharacterized protein family, UPF0114
FTW_RS09225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FTW_RS09235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FTW_RS09255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FTW_RS09275	COG0009	L-threonylcarbamoyladenylate synthase
FTW_RS09285	COG0204	Acyl-transferase
FTW_RS09290	COG0658	competence protein
FTW_RS09290	COG2333	competence protein COMEC
FTW_RS09295	COG4067	protein conserved in archaea
FTW_RS09295	COG0189	ligase activity
FTW_RS09300	COG0456	acetyltransferase
FTW_RS09310	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FTW_RS09325	COG3335	DDE superfamily endonuclease
FTW_RS09345	COG0778	Nitroreductase
FTW_RS09355	COG0814	amino acid
FTW_RS09380	COG2814	Major facilitator Superfamily
FTW_RS09390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FTW_RS09395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTW_RS09420	COG0242	peptide deformylase activity
FTW_RS09430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTW_RS09430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTW_RS09440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTW_RS09440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTW_RS09450	COG3335	DDE superfamily endonuclease
FTW_RS09460	COG0814	amino acid
FTW_RS09470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FTW_RS09475	COG0540	Belongs to the ATCase OTCase family
FTW_RS09480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FTW_RS09485	COG0505	Belongs to the CarA family
FTW_RS09530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTW_RS09540	COG0583	DNA-binding transcription factor activity
FTW_RS09565	COG0284	orotidine-5'-phosphate decarboxylase activity
FTW_RS09570	COG0167	dihydroorotate dehydrogenase activity
FTW_RS09585	COG1621	beta-fructofuranosidase activity
FTW_RS09590	COG3335	DDE superfamily endonuclease
FTW_RS09610	COG3961	Belongs to the TPP enzyme family
FTW_RS09630	COG0425	Belongs to the sulfur carrier protein TusA family
FTW_RS09630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTW_RS09645	COG2137	regulation of response to DNA damage stimulus
FTW_RS09650	COG0629	single-stranded DNA binding
FTW_RS09660	COG0280	phosphate acetyltransferase
FTW_RS09660	COG0857	belongs to the CobB CobQ family
FTW_RS09670	COG3335	DDE superfamily endonuclease
FTW_RS09710	COG3335	DDE superfamily endonuclease
FTW_RS09720	COG0488	(ABC) transporter
FTW_RS09725	COG0477	Major facilitator Superfamily
FTW_RS09750	COG0583	DNA-binding transcription factor activity
FTW_RS09770	COG0308	aminopeptidase N
FTW_RS09780	COG0071	Belongs to the small heat shock protein (HSP20) family
FTW_RS09785	COG0134	indole-3-glycerol-phosphate synthase activity
FTW_RS09785	COG0135	phosphoribosylanthranilate isomerase activity
FTW_RS09795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTW_RS09820	COG0512	Glutamine amidotransferase of anthranilate synthase
FTW_RS09825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FTW_RS09885	COG1288	antiporter activity
FTW_RS09890	COG1288	antiporter activity