locus-tag	class	description
FRANCCI3_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRANCCI3_RS00020	COG0592	DNA-directed DNA polymerase activity
FRANCCI3_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRANCCI3_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FRANCCI3_RS00035	COG0187	DNA topoisomerase II activity
FRANCCI3_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRANCCI3_RS00055	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS00075	COG0242	peptide deformylase activity
FRANCCI3_RS00110	COG1857	crispr-associated protein
FRANCCI3_RS00125	COG1518	maintenance of DNA repeat elements
FRANCCI3_RS00130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRANCCI3_RS00135	COG1764	response to oxidative stress
FRANCCI3_RS00160	COG1881	PFAM PEBP family protein
FRANCCI3_RS00200	COG1196	nuclear chromosome segregation
FRANCCI3_RS00200	COG0741	lytic transglycosylase activity
FRANCCI3_RS00200	COG0739	heme binding
FRANCCI3_RS00205	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS00215	COG0166	Belongs to the GPI family
FRANCCI3_RS00240	COG1131	(ABC) transporter
FRANCCI3_RS00255	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRANCCI3_RS00260	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS00275	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRANCCI3_RS00280	COG0022	dehydrogenase e1 component
FRANCCI3_RS00295	COG2843	Capsule synthesis protein
FRANCCI3_RS00340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRANCCI3_RS00345	COG1970	mechanosensitive ion channel activity
FRANCCI3_RS00370	COG1573	uracil-dna glycosylase
FRANCCI3_RS00375	COG1376	ErfK ybiS ycfS ynhG family protein
FRANCCI3_RS00385	COG0259	pyridoxamine-phosphate oxidase activity
FRANCCI3_RS00400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FRANCCI3_RS00405	COG0372	Belongs to the citrate synthase family
FRANCCI3_RS00410	COG2197	response regulator
FRANCCI3_RS00415	COG4585	Histidine kinase
FRANCCI3_RS00435	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS00465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRANCCI3_RS00565	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS00565	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRANCCI3_RS00585	COG0582	viral genome integration into host DNA
FRANCCI3_RS00645	COG2856	Zn peptidase
FRANCCI3_RS00705	COG1487	ribonuclease activity
FRANCCI3_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS00735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRANCCI3_RS00740	COG4941	Belongs to the sigma-70 factor family
FRANCCI3_RS00835	COG1595	DNA-templated transcription, initiation
FRANCCI3_RS00855	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS00905	COG0076	glutamate decarboxylase activity
FRANCCI3_RS00985	COG0732	type I restriction modification DNA specificity domain
FRANCCI3_RS01005	COG0577	efflux transmembrane transporter activity
FRANCCI3_RS01005	COG1136	(ABC) transporter
FRANCCI3_RS01010	COG1136	(ABC) transporter
FRANCCI3_RS01010	COG0577	efflux transmembrane transporter activity
FRANCCI3_RS01090	COG2183	response to ionizing radiation
FRANCCI3_RS01115	COG2267	carboxylic ester hydrolase activity
FRANCCI3_RS01125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FRANCCI3_RS01130	COG1088	dTDP-glucose 4,6-dehydratase activity
FRANCCI3_RS01175	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS01180	COG2205	protein histidine kinase activity
FRANCCI3_RS01185	COG2890	protein-(glutamine-N5) methyltransferase activity
FRANCCI3_RS01190	COG2304	oxidoreductase activity
FRANCCI3_RS01210	COG1487	ribonuclease activity
FRANCCI3_RS01215	COG0326	Molecular chaperone. Has ATPase activity
FRANCCI3_RS01220	COG4941	Belongs to the sigma-70 factor family
FRANCCI3_RS01225	COG3795	YCII-related domain
FRANCCI3_RS01245	COG1116	anion transmembrane transporter activity
FRANCCI3_RS01250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRANCCI3_RS01270	COG0501	Belongs to the peptidase M48B family
FRANCCI3_RS01280	COG1271	oxidase subunit
FRANCCI3_RS01285	COG1294	oxidase, subunit
FRANCCI3_RS01300	COG1278	Cold shock
FRANCCI3_RS01335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRANCCI3_RS01340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRANCCI3_RS01390	COG4372	Transposase
FRANCCI3_RS01400	COG0076	glutamate decarboxylase activity
FRANCCI3_RS01410	COG0590	tRNA wobble adenosine to inosine editing
FRANCCI3_RS01435	COG3103	Sh3 type 3 domain protein
FRANCCI3_RS01435	COG1388	LysM domain
FRANCCI3_RS01435	COG0791	NLP P60 protein
FRANCCI3_RS01445	COG0598	Magnesium transport protein CorA
FRANCCI3_RS01460	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS01465	COG4251	negative regulation of phosphorylation
FRANCCI3_RS01475	COG4124	Belongs to the glycosyl hydrolase 26 family
FRANCCI3_RS01510	COG2197	response regulator
FRANCCI3_RS01515	COG4585	Histidine kinase
FRANCCI3_RS01520	COG4585	Histidine kinase
FRANCCI3_RS01535	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS01540	COG2205	protein histidine kinase activity
FRANCCI3_RS01555	COG2378	regulation of single-species biofilm formation
FRANCCI3_RS01575	COG3268	Saccharopine dehydrogenase
FRANCCI3_RS01585	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS01590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRANCCI3_RS01595	COG2205	protein histidine kinase activity
FRANCCI3_RS01600	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS01690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRANCCI3_RS01700	COG0559	Belongs to the binding-protein-dependent transport system permease family
FRANCCI3_RS01730	COG4221	oxidoreductase activity
FRANCCI3_RS01745	COG4221	oxidoreductase activity
FRANCCI3_RS01750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRANCCI3_RS01780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRANCCI3_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS01825	COG3447	MASE1 domain protein
FRANCCI3_RS01825	COG5001	Diguanylate cyclase
FRANCCI3_RS01825	COG5002	protein histidine kinase activity
FRANCCI3_RS01830	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS01855	COG3304	Inner membrane component domain
FRANCCI3_RS01895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FRANCCI3_RS01925	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FRANCCI3_RS01940	COG5433	transposase activity
FRANCCI3_RS02060	COG3706	GGDEF domain
FRANCCI3_RS02080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRANCCI3_RS02095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FRANCCI3_RS02110	COG3883	PFAM NLP P60 protein
FRANCCI3_RS02110	COG0791	NLP P60 protein
FRANCCI3_RS02130	COG0659	secondary active sulfate transmembrane transporter activity
FRANCCI3_RS02145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FRANCCI3_RS02170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRANCCI3_RS02200	COG1921	L-seryl-tRNASec selenium transferase activity
FRANCCI3_RS02215	COG0456	acetyltransferase
FRANCCI3_RS02220	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS02265	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FRANCCI3_RS02285	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS02290	COG0667	Aldo Keto reductase
FRANCCI3_RS02305	COG1196	nuclear chromosome segregation
FRANCCI3_RS02310	COG1175	transmembrane transport
FRANCCI3_RS02315	COG0395	ABC-type sugar transport system, permease component
FRANCCI3_RS02325	COG3842	ATPase activity
FRANCCI3_RS02335	COG0354	folic acid binding
FRANCCI3_RS02340	COG0588	phosphoglycerate mutase activity
FRANCCI3_RS02350	COG5002	protein histidine kinase activity
FRANCCI3_RS02355	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS02360	COG0248	Ppx GppA phosphatase
FRANCCI3_RS02365	COG1082	Xylose isomerase domain protein TIM barrel
FRANCCI3_RS02370	COG2226	methyltransferase
FRANCCI3_RS02380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FRANCCI3_RS02415	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FRANCCI3_RS02420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRANCCI3_RS02425	COG0181	hydroxymethylbilane synthase activity
FRANCCI3_RS02430	COG1648	precorrin-2 dehydrogenase activity
FRANCCI3_RS02430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRANCCI3_RS02435	COG0113	porphobilinogen synthase activity
FRANCCI3_RS02500	COG0789	Transcriptional regulator
FRANCCI3_RS02505	COG0018	arginyl-trna synthetase
FRANCCI3_RS02515	COG0018	arginyl-trna synthetase
FRANCCI3_RS02525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRANCCI3_RS02530	COG0406	alpha-ribazole phosphatase activity
FRANCCI3_RS02540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRANCCI3_RS02545	COG0785	Cytochrome C biogenesis protein
FRANCCI3_RS02555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRANCCI3_RS02565	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRANCCI3_RS02570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRANCCI3_RS02575	COG0163	prenyltransferase activity
FRANCCI3_RS02585	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRANCCI3_RS02600	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FRANCCI3_RS02630	COG0175	sulfate reduction
FRANCCI3_RS02645	COG0492	ferredoxin-NADP+ reductase activity
FRANCCI3_RS02660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRANCCI3_RS02665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRANCCI3_RS02670	COG2226	methyltransferase
FRANCCI3_RS02690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRANCCI3_RS02695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRANCCI3_RS02700	COG0649	NAD binding
FRANCCI3_RS02715	COG1034	ATP synthesis coupled electron transport
FRANCCI3_RS02720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRANCCI3_RS02725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRANCCI3_RS02730	COG0839	Belongs to the complex I subunit 6 family
FRANCCI3_RS02735	COG0713	ATP synthesis coupled electron transport
FRANCCI3_RS02740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRANCCI3_RS02750	COG1007	ATP synthesis coupled electron transport
FRANCCI3_RS02755	COG0142	geranyltranstransferase activity
FRANCCI3_RS02765	COG1013	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS02770	COG0674	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS02770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FRANCCI3_RS02780	COG0501	Belongs to the peptidase M48B family
FRANCCI3_RS02785	COG1666	GTP binding
FRANCCI3_RS02795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRANCCI3_RS02825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRANCCI3_RS02830	COG2030	dehydratase
FRANCCI3_RS02840	COG0436	Aminotransferase
FRANCCI3_RS02850	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRANCCI3_RS02855	COG0250	Participates in transcription elongation, termination and antitermination
FRANCCI3_RS02860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRANCCI3_RS02865	COG0081	regulation of translation
FRANCCI3_RS02870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRANCCI3_RS02875	COG0222	ribosome binding
FRANCCI3_RS02880	COG0085	RNA polymerase activity
FRANCCI3_RS02885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRANCCI3_RS02900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRANCCI3_RS02905	COG0049	tRNA binding
FRANCCI3_RS02910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRANCCI3_RS02915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRANCCI3_RS02920	COG0051	transcription antitermination factor activity, RNA binding
FRANCCI3_RS02925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRANCCI3_RS02930	COG0088	Forms part of the polypeptide exit tunnel
FRANCCI3_RS02935	COG0089	rRNA binding
FRANCCI3_RS02940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRANCCI3_RS02945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRANCCI3_RS02950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRANCCI3_RS02955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRANCCI3_RS02960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRANCCI3_RS02965	COG0255	Belongs to the universal ribosomal protein uL29 family
FRANCCI3_RS02970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRANCCI3_RS02975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRANCCI3_RS02980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRANCCI3_RS02985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRANCCI3_RS02990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRANCCI3_RS02995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRANCCI3_RS03000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRANCCI3_RS03005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRANCCI3_RS03010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRANCCI3_RS03015	COG1841	ribosomal large subunit assembly
FRANCCI3_RS03020	COG0200	Binds to the 23S rRNA
FRANCCI3_RS03030	COG0563	adenylate kinase activity
FRANCCI3_RS03040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRANCCI3_RS03045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRANCCI3_RS03050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRANCCI3_RS03055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRANCCI3_RS03060	COG0202	RNA polymerase activity
FRANCCI3_RS03065	COG0203	ribosomal protein L17
FRANCCI3_RS03070	COG0101	tRNA pseudouridine synthase activity
FRANCCI3_RS03080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRANCCI3_RS03090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRANCCI3_RS03095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRANCCI3_RS03110	COG0736	holo-[acyl-carrier-protein] synthase activity
FRANCCI3_RS03120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRANCCI3_RS03130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRANCCI3_RS03140	COG0802	atpase or kinase
FRANCCI3_RS03145	COG0456	acetyltransferase
FRANCCI3_RS03145	COG1214	PFAM Peptidase M22, glycoprotease
FRANCCI3_RS03150	COG0456	acetyltransferase
FRANCCI3_RS03155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRANCCI3_RS03170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRANCCI3_RS03175	COG0459	protein refolding
FRANCCI3_RS03195	COG0516	GMP reductase activity
FRANCCI3_RS03230	COG2018	Roadblock/LC7 domain
FRANCCI3_RS03240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRANCCI3_RS03240	COG0519	Catalyzes the synthesis of GMP from XMP
FRANCCI3_RS03245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRANCCI3_RS03260	COG0825	malonyl-CoA metabolic process
FRANCCI3_RS03260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRANCCI3_RS03270	COG0045	succinate-CoA ligase (ADP-forming) activity
FRANCCI3_RS03300	COG0138	bifunctional purine biosynthesis protein purh
FRANCCI3_RS03315	COG0644	oxidoreductase
FRANCCI3_RS03385	COG3177	Filamentation induced by cAMP protein fic
FRANCCI3_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS03425	COG2009	succinate dehydrogenase
FRANCCI3_RS03450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRANCCI3_RS03455	COG0519	Catalyzes the synthesis of GMP from XMP
FRANCCI3_RS03460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FRANCCI3_RS03470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRANCCI3_RS03485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRANCCI3_RS03490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FRANCCI3_RS03495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FRANCCI3_RS03495	COG1473	amidohydrolase
FRANCCI3_RS03515	COG4770	biotin carboxylase activity
FRANCCI3_RS03525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRANCCI3_RS03555	COG1309	transcriptional regulator
FRANCCI3_RS03580	COG1316	TRANSCRIPTIONal
FRANCCI3_RS03585	COG1316	TRANSCRIPTIONal
FRANCCI3_RS03655	COG0515	serine threonine protein kinase
FRANCCI3_RS03655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRANCCI3_RS03665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRANCCI3_RS03675	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS03680	COG2226	methyltransferase
FRANCCI3_RS03695	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS03705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRANCCI3_RS03710	COG0592	DNA-directed DNA polymerase activity
FRANCCI3_RS03715	COG3511	phospholipase C
FRANCCI3_RS03725	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FRANCCI3_RS03725	COG0778	Nitroreductase
FRANCCI3_RS03730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FRANCCI3_RS03735	COG1309	transcriptional regulator
FRANCCI3_RS03745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRANCCI3_RS03785	COG2835	tetraacyldisaccharide 4'-kinase activity
FRANCCI3_RS03790	COG2222	sugar isomerase
FRANCCI3_RS03795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRANCCI3_RS03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRANCCI3_RS03820	COG0714	Associated with various cellular activities
FRANCCI3_RS03845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FRANCCI3_RS03850	COG2197	response regulator
FRANCCI3_RS03860	COG0653	protein targeting
FRANCCI3_RS03910	COG3743	rRNA binding
FRANCCI3_RS03910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRANCCI3_RS03975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FRANCCI3_RS03990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRANCCI3_RS03990	COG2146	nitrite reductase [NAD(P)H] activity
FRANCCI3_RS04000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRANCCI3_RS04000	COG1648	precorrin-2 dehydrogenase activity
FRANCCI3_RS04010	COG2884	Cell division ATP-binding protein ftsE
FRANCCI3_RS04015	COG2177	Part of the ABC transporter FtsEX involved in
FRANCCI3_RS04025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRANCCI3_RS04035	COG2084	Dehydrogenase
FRANCCI3_RS04080	COG1136	(ABC) transporter
FRANCCI3_RS04105	COG2409	Drug exporters of the RND superfamily
FRANCCI3_RS04115	COG0300	oxidoreductase activity
FRANCCI3_RS04130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FRANCCI3_RS04140	COG1657	PFAM Prenyltransferase squalene oxidase
FRANCCI3_RS04170	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS04175	COG0829	nickel cation binding
FRANCCI3_RS04185	COG0804	urea catabolic process
FRANCCI3_RS04190	COG0832	Belongs to the urease beta subunit family
FRANCCI3_RS04195	COG0831	urea catabolic process
FRANCCI3_RS04200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FRANCCI3_RS04220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRANCCI3_RS04225	COG4266	Belongs to the allantoicase family
FRANCCI3_RS04235	COG2351	hydroxyisourate hydrolase activity
FRANCCI3_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRANCCI3_RS04260	COG0010	Belongs to the arginase family
FRANCCI3_RS04280	COG1131	(ABC) transporter
FRANCCI3_RS04300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRANCCI3_RS04325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRANCCI3_RS04330	COG0243	molybdopterin cofactor binding
FRANCCI3_RS04335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRANCCI3_RS04360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRANCCI3_RS04365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FRANCCI3_RS04370	COG1234	tRNA 3'-trailer cleavage
FRANCCI3_RS04375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRANCCI3_RS04385	COG2084	Dehydrogenase
FRANCCI3_RS04570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRANCCI3_RS04570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRANCCI3_RS04620	COG2197	response regulator
FRANCCI3_RS04635	COG3321	synthase
FRANCCI3_RS04635	COG0604	alcohol dehydrogenase
FRANCCI3_RS04655	COG1819	glycosyl
FRANCCI3_RS04685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FRANCCI3_RS04690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRANCCI3_RS04695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FRANCCI3_RS04700	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS04705	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS04720	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS04735	COG1716	ATPase activity
FRANCCI3_RS04735	COG0842	Transport permease protein
FRANCCI3_RS04735	COG1131	(ABC) transporter
FRANCCI3_RS04740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRANCCI3_RS04740	COG0515	serine threonine protein kinase
FRANCCI3_RS04755	COG0693	protein deglycase activity
FRANCCI3_RS04780	COG2442	InterPro IPR007367
FRANCCI3_RS04800	COG2826	transposase and inactivated derivatives, IS30 family
FRANCCI3_RS04815	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS04815	COG0247	lactate metabolic process
FRANCCI3_RS04825	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS04830	COG1215	transferase activity, transferring glycosyl groups
FRANCCI3_RS04880	COG1252	NADH dehydrogenase
FRANCCI3_RS04885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRANCCI3_RS04890	COG5002	protein histidine kinase activity
FRANCCI3_RS04895	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS04955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRANCCI3_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS04960	COG3321	synthase
FRANCCI3_RS04960	COG0604	alcohol dehydrogenase
FRANCCI3_RS04980	COG0475	glutathione-regulated potassium exporter activity
FRANCCI3_RS05015	COG0275	rRNA processing
FRANCCI3_RS05050	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS05060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRANCCI3_RS05080	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS05190	COG0726	polysaccharide deacetylase
FRANCCI3_RS05195	COG1012	belongs to the aldehyde dehydrogenase family
FRANCCI3_RS05200	COG2197	response regulator
FRANCCI3_RS05210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FRANCCI3_RS05225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRANCCI3_RS05245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRANCCI3_RS05250	COG1741	Belongs to the pirin family
FRANCCI3_RS05255	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FRANCCI3_RS05265	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS05280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FRANCCI3_RS05280	COG2755	lipolytic protein G-D-S-L family
FRANCCI3_RS05295	COG0539	negative regulation of cytoplasmic translation
FRANCCI3_RS05305	COG0386	Belongs to the glutathione peroxidase family
FRANCCI3_RS05355	COG0309	Hydrogenase expression formation protein (HypE)
FRANCCI3_RS05365	COG0298	carbon dioxide binding
FRANCCI3_RS05370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FRANCCI3_RS05440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRANCCI3_RS05460	COG3654	unkown
FRANCCI3_RS05555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FRANCCI3_RS05570	COG1309	transcriptional regulator
FRANCCI3_RS05580	COG0477	Major facilitator Superfamily
FRANCCI3_RS05585	COG5433	transposase activity
FRANCCI3_RS05630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS05715	COG0582	viral genome integration into host DNA
FRANCCI3_RS05725	COG0629	single-stranded DNA binding
FRANCCI3_RS05750	COG0366	Alpha amylase catalytic
FRANCCI3_RS05760	COG0702	epimerase
FRANCCI3_RS05770	COG0668	transmembrane transport
FRANCCI3_RS05780	COG2205	protein histidine kinase activity
FRANCCI3_RS05825	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS05830	COG4981	capsule polysaccharide biosynthetic process
FRANCCI3_RS05885	COG2208	phosphoserine phosphatase activity
FRANCCI3_RS05885	COG2770	Histidine kinase
FRANCCI3_RS05895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRANCCI3_RS05910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRANCCI3_RS05910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRANCCI3_RS05920	COG1716	ATPase activity
FRANCCI3_RS05920	COG1131	(ABC) transporter
FRANCCI3_RS05920	COG0842	Transport permease protein
FRANCCI3_RS05925	COG0297	glycogen (starch) synthase activity
FRANCCI3_RS05930	COG0167	dihydroorotate dehydrogenase activity
FRANCCI3_RS05965	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS05970	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS06035	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRANCCI3_RS06040	COG0740	serine-type endopeptidase activity
FRANCCI3_RS06045	COG0740	serine-type endopeptidase activity
FRANCCI3_RS06050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRANCCI3_RS06055	COG0285	dihydrofolate synthase activity
FRANCCI3_RS06060	COG0285	dihydrofolate synthase activity
FRANCCI3_RS06065	COG0105	UTP biosynthetic process
FRANCCI3_RS06070	COG1077	Cell shape determining protein MreB Mrl
FRANCCI3_RS06090	COG0772	Belongs to the SEDS family
FRANCCI3_RS06105	COG1530	ribonuclease E activity
FRANCCI3_RS06115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRANCCI3_RS06120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRANCCI3_RS06125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRANCCI3_RS06130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FRANCCI3_RS06140	COG0419	ATPase involved in DNA repair
FRANCCI3_RS06145	COG0420	3'-5' exonuclease activity
FRANCCI3_RS06150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FRANCCI3_RS06155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRANCCI3_RS06160	COG0542	response to heat
FRANCCI3_RS06175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRANCCI3_RS06185	COG0588	phosphoglycerate mutase activity
FRANCCI3_RS06225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRANCCI3_RS06235	COG1309	transcriptional regulator
FRANCCI3_RS06270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRANCCI3_RS06275	COG0204	Acyl-transferase
FRANCCI3_RS06305	COG2333	competence protein COMEC
FRANCCI3_RS06305	COG0658	competence protein
FRANCCI3_RS06320	COG0268	Binds directly to 16S ribosomal RNA
FRANCCI3_RS06325	COG0481	GTPase activity
FRANCCI3_RS06340	COG1420	regulation of RNA biosynthetic process
FRANCCI3_RS06345	COG0484	heat shock protein binding
FRANCCI3_RS06350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRANCCI3_RS06360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRANCCI3_RS06375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRANCCI3_RS06380	COG1381	Involved in DNA repair and RecF pathway recombination
FRANCCI3_RS06385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRANCCI3_RS06400	COG0574	Belongs to the PEP-utilizing enzyme family
FRANCCI3_RS06400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRANCCI3_RS06420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRANCCI3_RS06425	COG0358	DNA primase activity
FRANCCI3_RS06430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRANCCI3_RS06460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRANCCI3_RS06475	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS06530	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS06535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRANCCI3_RS06540	COG0673	inositol 2-dehydrogenase activity
FRANCCI3_RS06565	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS06570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRANCCI3_RS06575	COG0483	inositol monophosphate 1-phosphatase activity
FRANCCI3_RS06580	COG0525	valine-tRNA ligase activity
FRANCCI3_RS06585	COG2223	nitrite transmembrane transporter activity
FRANCCI3_RS06590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRANCCI3_RS06600	COG0756	dUTP diphosphatase activity
FRANCCI3_RS06625	COG0569	domain protein
FRANCCI3_RS06630	COG0531	amino acid
FRANCCI3_RS06635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRANCCI3_RS06640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FRANCCI3_RS06655	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRANCCI3_RS06655	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS06660	COG0183	Belongs to the thiolase family
FRANCCI3_RS06680	COG2814	Major facilitator Superfamily
FRANCCI3_RS06685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRANCCI3_RS06690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FRANCCI3_RS06695	COG3253	May function as heme-dependent peroxidase
FRANCCI3_RS06700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRANCCI3_RS06705	COG0529	Catalyzes the synthesis of activated sulfate
FRANCCI3_RS06705	COG2046	Belongs to the sulfate adenylyltransferase family
FRANCCI3_RS06710	COG1218	3'(2'),5'-bisphosphate nucleotidase
FRANCCI3_RS06715	COG0175	sulfate reduction
FRANCCI3_RS06785	COG1335	isochorismatase
FRANCCI3_RS06795	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRANCCI3_RS06815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRANCCI3_RS06840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRANCCI3_RS06845	COG1560	Kdo2-lipid A biosynthetic process
FRANCCI3_RS06850	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS06860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FRANCCI3_RS06865	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FRANCCI3_RS06870	COG0217	transcriptional regulatory protein
FRANCCI3_RS06875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRANCCI3_RS06880	COG0632	four-way junction helicase activity
FRANCCI3_RS06885	COG2255	four-way junction helicase activity
FRANCCI3_RS06895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRANCCI3_RS06905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRANCCI3_RS06910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRANCCI3_RS06915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRANCCI3_RS06935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRANCCI3_RS06940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRANCCI3_RS06950	COG2304	oxidoreductase activity
FRANCCI3_RS06960	COG0714	Associated with various cellular activities
FRANCCI3_RS06970	COG0142	geranyltranstransferase activity
FRANCCI3_RS07055	COG1305	Transglutaminase-like
FRANCCI3_RS07065	COG0714	Associated with various cellular activities
FRANCCI3_RS07070	COG2001	Belongs to the MraZ family
FRANCCI3_RS07075	COG0275	rRNA processing
FRANCCI3_RS07085	COG0768	penicillin binding
FRANCCI3_RS07090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRANCCI3_RS07100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRANCCI3_RS07105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRANCCI3_RS07115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRANCCI3_RS07125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRANCCI3_RS07130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRANCCI3_RS07135	COG1496	oxidoreductase activity
FRANCCI3_RS07145	COG1799	cell septum assembly
FRANCCI3_RS07160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRANCCI3_RS07165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRANCCI3_RS07220	COG3323	Protein of unknown function (DUF1653)
FRANCCI3_RS07220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRANCCI3_RS07280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRANCCI3_RS07300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRANCCI3_RS07305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRANCCI3_RS07320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FRANCCI3_RS07360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRANCCI3_RS07380	COG0509	glycine decarboxylation via glycine cleavage system
FRANCCI3_RS07420	COG1674	ftsk spoiiie
FRANCCI3_RS07445	COG2062	phosphohistidine phosphatase, SixA
FRANCCI3_RS07485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FRANCCI3_RS07495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRANCCI3_RS07555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRANCCI3_RS07595	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FRANCCI3_RS07610	COG0789	Transcriptional regulator
FRANCCI3_RS07615	COG0667	Aldo Keto reductase
FRANCCI3_RS07625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRANCCI3_RS07675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRANCCI3_RS07705	COG1609	Transcriptional regulator
FRANCCI3_RS07710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FRANCCI3_RS07725	COG2409	Drug exporters of the RND superfamily
FRANCCI3_RS07755	COG2197	response regulator
FRANCCI3_RS07760	COG1063	alcohol dehydrogenase
FRANCCI3_RS07795	COG1309	transcriptional regulator
FRANCCI3_RS07800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRANCCI3_RS07810	COG2814	Major facilitator Superfamily
FRANCCI3_RS07830	COG1316	TRANSCRIPTIONal
FRANCCI3_RS07845	COG0427	acetyl-CoA hydrolase
FRANCCI3_RS07865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRANCCI3_RS07875	COG1216	Glycosyl transferase, family 2
FRANCCI3_RS07890	COG2244	polysaccharide biosynthetic process
FRANCCI3_RS07895	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS07925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRANCCI3_RS07930	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS07965	COG1216	Glycosyl transferase, family 2
FRANCCI3_RS07980	COG3842	ATPase activity
FRANCCI3_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS08010	COG1132	(ABC) transporter
FRANCCI3_RS08030	COG2124	cytochrome p450
FRANCCI3_RS08045	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS08055	COG2124	cytochrome p450
FRANCCI3_RS08075	COG2124	cytochrome p450
FRANCCI3_RS08100	COG3447	MASE1 domain protein
FRANCCI3_RS08100	COG5001	Diguanylate cyclase
FRANCCI3_RS08100	COG5002	protein histidine kinase activity
FRANCCI3_RS08165	COG0237	dephospho-CoA kinase activity
FRANCCI3_RS08170	COG0556	nucleotide-excision repair
FRANCCI3_RS08195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRANCCI3_RS08205	COG0322	excinuclease ABC activity
FRANCCI3_RS08210	COG1660	Displays ATPase and GTPase activities
FRANCCI3_RS08215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FRANCCI3_RS08220	COG1481	regulation of sporulation
FRANCCI3_RS08225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRANCCI3_RS08230	COG0126	phosphoglycerate kinase activity
FRANCCI3_RS08235	COG0149	triose-phosphate isomerase activity
FRANCCI3_RS08265	COG0363	glucosamine-6-phosphate deaminase activity
FRANCCI3_RS08280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRANCCI3_RS08285	COG0109	protoheme IX farnesyltransferase activity
FRANCCI3_RS08325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRANCCI3_RS08345	COG0719	Fe-S assembly protein
FRANCCI3_RS08355	COG0396	ATPase activity
FRANCCI3_RS08360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRANCCI3_RS08365	COG0822	iron-sulfur transferase activity
FRANCCI3_RS08370	COG2151	metal-sulfur cluster biosynthetic enzyme
FRANCCI3_RS08375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FRANCCI3_RS08380	COG0297	glycogen (starch) synthase activity
FRANCCI3_RS08390	COG0488	(ABC) transporter
FRANCCI3_RS08415	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS08415	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRANCCI3_RS08420	COG1132	(ABC) transporter
FRANCCI3_RS08450	COG1487	ribonuclease activity
FRANCCI3_RS08530	COG0791	NLP P60 protein
FRANCCI3_RS08530	COG3883	PFAM NLP P60 protein
FRANCCI3_RS08815	COG0302	gtp cyclohydrolase
FRANCCI3_RS08820	COG0494	nUDIX hydrolase
FRANCCI3_RS08835	COG0516	GMP reductase activity
FRANCCI3_RS08835	COG0517	IMP dehydrogenase activity
FRANCCI3_RS08840	COG0602	queuosine metabolic process
FRANCCI3_RS08875	COG0187	DNA topoisomerase II activity
FRANCCI3_RS08895	COG3119	arylsulfatase activity
FRANCCI3_RS08905	COG1609	Transcriptional regulator
FRANCCI3_RS08935	COG2226	methyltransferase
FRANCCI3_RS09040	COG0587	DNA-directed DNA polymerase activity
FRANCCI3_RS09055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRANCCI3_RS09070	COG0667	Aldo Keto reductase
FRANCCI3_RS09095	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS09135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRANCCI3_RS09140	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRANCCI3_RS09155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS09195	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRANCCI3_RS09205	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRANCCI3_RS09335	COG3311	Transcriptional regulator
FRANCCI3_RS09340	COG1569	PIN domain
FRANCCI3_RS09355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRANCCI3_RS09360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRANCCI3_RS09365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRANCCI3_RS09370	COG4372	Transposase
FRANCCI3_RS09385	COG0180	Tryptophanyl-tRNA synthetase
FRANCCI3_RS09485	COG0579	oxidoreductase
FRANCCI3_RS09490	COG3387	PFAM Glycoside hydrolase 15-related
FRANCCI3_RS09555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRANCCI3_RS09575	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS09600	COG1376	ErfK ybiS ycfS ynhG family protein
FRANCCI3_RS09615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRANCCI3_RS09635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FRANCCI3_RS09650	COG4372	Transposase
FRANCCI3_RS09660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS09675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRANCCI3_RS09680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRANCCI3_RS09690	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS09700	COG0583	DNA-binding transcription factor activity
FRANCCI3_RS09730	COG0375	protein maturation
FRANCCI3_RS09755	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FRANCCI3_RS09775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FRANCCI3_RS09780	COG0298	carbon dioxide binding
FRANCCI3_RS09795	COG1278	Cold shock
FRANCCI3_RS09850	COG2801	Transposase and inactivated derivatives
FRANCCI3_RS09900	COG1737	Transcriptional regulator
FRANCCI3_RS09915	COG1376	ErfK ybiS ycfS ynhG family protein
FRANCCI3_RS09960	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS09960	COG0247	lactate metabolic process
FRANCCI3_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS09985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRANCCI3_RS09995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRANCCI3_RS10070	COG1733	regulation of RNA biosynthetic process
FRANCCI3_RS10080	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS10090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRANCCI3_RS10110	COG3848	Pyruvate phosphate dikinase
FRANCCI3_RS10110	COG0574	Belongs to the PEP-utilizing enzyme family
FRANCCI3_RS10115	COG0477	Major facilitator Superfamily
FRANCCI3_RS10125	COG0156	8-amino-7-oxononanoate synthase activity
FRANCCI3_RS10135	COG2910	NAD(P)H-binding
FRANCCI3_RS10190	COG0674	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS10190	COG1013	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS10190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FRANCCI3_RS10190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRANCCI3_RS10195	COG1192	Involved in chromosome partitioning
FRANCCI3_RS10230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS10265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRANCCI3_RS10295	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS10355	COG4372	Transposase
FRANCCI3_RS10405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FRANCCI3_RS10410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS10430	COG0189	ligase activity
FRANCCI3_RS10445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FRANCCI3_RS10450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRANCCI3_RS10500	COG2814	Major facilitator Superfamily
FRANCCI3_RS10510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRANCCI3_RS10530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRANCCI3_RS10535	COG0667	Aldo Keto reductase
FRANCCI3_RS10620	COG0259	pyridoxamine-phosphate oxidase activity
FRANCCI3_RS10630	COG2267	carboxylic ester hydrolase activity
FRANCCI3_RS10640	COG0601	transmembrane transport
FRANCCI3_RS10645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRANCCI3_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS10665	COG5433	transposase activity
FRANCCI3_RS10670	COG3629	intracellular signal transduction
FRANCCI3_RS10670	COG3903	Transcriptional regulator
FRANCCI3_RS10680	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS10725	COG0321	lipoyl(octanoyl) transferase activity
FRANCCI3_RS10745	COG3287	FIST C domain
FRANCCI3_RS10745	COG2200	EAL domain
FRANCCI3_RS10745	COG2199	diguanylate cyclase activity
FRANCCI3_RS10820	COG0784	Response regulator, receiver
FRANCCI3_RS10830	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FRANCCI3_RS10835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FRANCCI3_RS10840	COG3454	Phosphonate metabolism
FRANCCI3_RS10855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FRANCCI3_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS10870	COG1609	Transcriptional regulator
FRANCCI3_RS10875	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS10880	COG2301	Belongs to the HpcH HpaI aldolase family
FRANCCI3_RS10890	COG2030	dehydratase
FRANCCI3_RS10895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRANCCI3_RS10895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRANCCI3_RS10910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRANCCI3_RS10915	COG0443	Heat shock 70 kDa protein
FRANCCI3_RS10925	COG0459	protein refolding
FRANCCI3_RS10995	COG3119	arylsulfatase activity
FRANCCI3_RS11005	COG2267	carboxylic ester hydrolase activity
FRANCCI3_RS11035	COG3344	reverse transcriptase
FRANCCI3_RS11045	COG0596	Alpha beta hydrolase
FRANCCI3_RS11085	COG1733	regulation of RNA biosynthetic process
FRANCCI3_RS11090	COG2353	YceI-like domain
FRANCCI3_RS11140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FRANCCI3_RS11165	COG0477	Major facilitator Superfamily
FRANCCI3_RS11200	COG0501	Belongs to the peptidase M48B family
FRANCCI3_RS11220	COG1131	(ABC) transporter
FRANCCI3_RS11235	COG0145	ligase activity
FRANCCI3_RS11240	COG4647	ligase activity
FRANCCI3_RS11245	COG0145	ligase activity
FRANCCI3_RS11250	COG1063	alcohol dehydrogenase
FRANCCI3_RS11260	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
FRANCCI3_RS11270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRANCCI3_RS11275	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS11285	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS11300	COG0583	DNA-binding transcription factor activity
FRANCCI3_RS11305	COG1234	tRNA 3'-trailer cleavage
FRANCCI3_RS11310	COG1653	transport
FRANCCI3_RS11315	COG1175	transmembrane transport
FRANCCI3_RS11325	COG3842	ATPase activity
FRANCCI3_RS11395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRANCCI3_RS11410	COG0463	Glycosyl transferase, family 2
FRANCCI3_RS11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRANCCI3_RS11525	COG0644	oxidoreductase
FRANCCI3_RS11540	COG1797	cobyrinic acid a,c-diamide synthase activity
FRANCCI3_RS11555	COG1357	PFAM Pentapeptide repeats (8 copies)
FRANCCI3_RS11575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRANCCI3_RS11580	COG2261	transglycosylase associated protein
FRANCCI3_RS11625	COG2318	DinB family
FRANCCI3_RS11660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRANCCI3_RS11665	COG1993	acr, cog1993
FRANCCI3_RS11670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRANCCI3_RS11675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRANCCI3_RS11680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FRANCCI3_RS11765	COG4974	Belongs to the 'phage' integrase family
FRANCCI3_RS11910	COG5002	protein histidine kinase activity
FRANCCI3_RS11915	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS11970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRANCCI3_RS11985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRANCCI3_RS12010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRANCCI3_RS12015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRANCCI3_RS12020	COG3608	succinylglutamate desuccinylase aspartoacylase
FRANCCI3_RS12020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FRANCCI3_RS12045	COG3973	AAA domain
FRANCCI3_RS12060	COG2205	protein histidine kinase activity
FRANCCI3_RS12065	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS12070	COG1968	undecaprenyl-diphosphatase activity
FRANCCI3_RS12100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRANCCI3_RS12110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRANCCI3_RS12135	COG2814	Major facilitator Superfamily
FRANCCI3_RS12140	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS12150	COG4172	Belongs to the ABC transporter superfamily
FRANCCI3_RS12155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRANCCI3_RS12170	COG0583	DNA-binding transcription factor activity
FRANCCI3_RS12175	COG2200	EAL domain
FRANCCI3_RS12175	COG3287	FIST C domain
FRANCCI3_RS12175	COG2199	diguanylate cyclase activity
FRANCCI3_RS12185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRANCCI3_RS12190	COG0515	serine threonine protein kinase
FRANCCI3_RS12200	COG1045	serine acetyltransferase
FRANCCI3_RS12215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRANCCI3_RS12220	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS12225	COG0494	nUDIX hydrolase
FRANCCI3_RS12230	COG0584	glycerophosphoryl diester phosphodiesterase
FRANCCI3_RS12250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS12285	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS12290	COG2205	protein histidine kinase activity
FRANCCI3_RS12300	COG1136	(ABC) transporter
FRANCCI3_RS12300	COG0577	efflux transmembrane transporter activity
FRANCCI3_RS12340	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS12345	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS12350	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS12375	COG1132	(ABC) transporter
FRANCCI3_RS12400	COG1966	Carbon starvation protein
FRANCCI3_RS12450	COG3842	ATPase activity
FRANCCI3_RS12485	COG0077	Prephenate dehydratase
FRANCCI3_RS12490	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRANCCI3_RS12510	COG0723	plastoquinol--plastocyanin reductase activity
FRANCCI3_RS12520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRANCCI3_RS12530	COG0028	Belongs to the TPP enzyme family
FRANCCI3_RS12535	COG1032	radical SAM domain protein
FRANCCI3_RS12545	COG2837	iron assimilation
FRANCCI3_RS12560	COG0038	chloride channel
FRANCCI3_RS12565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRANCCI3_RS12590	COG0145	ligase activity
FRANCCI3_RS12595	COG4647	ligase activity
FRANCCI3_RS12600	COG0145	ligase activity
FRANCCI3_RS12620	COG0459	protein refolding
FRANCCI3_RS12625	COG1063	alcohol dehydrogenase
FRANCCI3_RS12650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRANCCI3_RS12670	COG4372	Transposase
FRANCCI3_RS12710	COG1595	DNA-templated transcription, initiation
FRANCCI3_RS12735	COG4372	Transposase
FRANCCI3_RS12855	COG2161	toxin-antitoxin pair type II binding
FRANCCI3_RS12860	COG4115	mRNA cleavage
FRANCCI3_RS12880	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRANCCI3_RS12900	COG2002	toxin-antitoxin pair type II binding
FRANCCI3_RS13010	COG2346	COG2346, Truncated hemoglobins
FRANCCI3_RS13020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRANCCI3_RS13040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRANCCI3_RS13060	COG2837	iron assimilation
FRANCCI3_RS13090	COG1230	cation diffusion facilitator family transporter
FRANCCI3_RS13100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRANCCI3_RS13105	COG1668	transmembrane transport
FRANCCI3_RS13110	COG4152	abc transporter atp-binding protein
FRANCCI3_RS13115	COG1492	cobalamin metabolic process
FRANCCI3_RS13130	COG0805	protein transport
FRANCCI3_RS13135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRANCCI3_RS13150	COG2378	regulation of single-species biofilm formation
FRANCCI3_RS13155	COG0545	Peptidyl-prolyl cis-trans isomerase
FRANCCI3_RS13160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FRANCCI3_RS13175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRANCCI3_RS13195	COG0456	acetyltransferase
FRANCCI3_RS13210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRANCCI3_RS13225	COG4221	oxidoreductase activity
FRANCCI3_RS13230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FRANCCI3_RS13235	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FRANCCI3_RS13245	COG4122	O-methyltransferase activity
FRANCCI3_RS13250	COG1222	aaa ATPase
FRANCCI3_RS13265	COG0517	IMP dehydrogenase activity
FRANCCI3_RS13265	COG1994	Peptidase M50
FRANCCI3_RS13275	COG0577	efflux transmembrane transporter activity
FRANCCI3_RS13275	COG1136	(ABC) transporter
FRANCCI3_RS13285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRANCCI3_RS13290	COG0646	methionine synthase
FRANCCI3_RS13290	COG1410	methionine synthase
FRANCCI3_RS13310	COG0215	cysteine-tRNA ligase activity
FRANCCI3_RS13335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRANCCI3_RS13380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRANCCI3_RS13385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FRANCCI3_RS13400	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS13400	COG0277	FAD linked oxidase domain protein
FRANCCI3_RS13405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRANCCI3_RS13410	COG0242	peptide deformylase activity
FRANCCI3_RS13420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRANCCI3_RS13425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FRANCCI3_RS13435	COG2409	Drug exporters of the RND superfamily
FRANCCI3_RS13440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRANCCI3_RS13455	COG0488	(ABC) transporter
FRANCCI3_RS13495	COG2161	toxin-antitoxin pair type II binding
FRANCCI3_RS13500	COG2026	Addiction module toxin, RelE StbE family
FRANCCI3_RS13530	COG0142	geranyltranstransferase activity
FRANCCI3_RS13550	COG3848	Pyruvate phosphate dikinase
FRANCCI3_RS13550	COG0574	Belongs to the PEP-utilizing enzyme family
FRANCCI3_RS13615	COG0018	arginyl-trna synthetase
FRANCCI3_RS13810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FRANCCI3_RS13810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRANCCI3_RS13890	COG0589	response to stress
FRANCCI3_RS13915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRANCCI3_RS13925	COG0747	negative chemotaxis
FRANCCI3_RS13940	COG2368	4-hydroxyphenylacetate
FRANCCI3_RS13950	COG1396	sequence-specific DNA binding
FRANCCI3_RS13955	COG0740	serine-type endopeptidase activity
FRANCCI3_RS13960	COG0740	serine-type endopeptidase activity
FRANCCI3_RS13975	COG0789	Transcriptional regulator
FRANCCI3_RS13980	COG0789	Transcriptional regulator
FRANCCI3_RS14010	COG1742	UPF0060 membrane protein
FRANCCI3_RS14030	COG0542	response to heat
FRANCCI3_RS14040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRANCCI3_RS14065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRANCCI3_RS14070	COG1968	undecaprenyl-diphosphatase activity
FRANCCI3_RS14095	COG3835	regulator
FRANCCI3_RS14100	COG0477	Major facilitator Superfamily
FRANCCI3_RS14110	COG2301	Belongs to the HpcH HpaI aldolase family
FRANCCI3_RS14115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRANCCI3_RS14145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRANCCI3_RS14165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRANCCI3_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
FRANCCI3_RS14195	COG0506	proline dehydrogenase activity
FRANCCI3_RS14205	COG2018	Roadblock/LC7 domain
FRANCCI3_RS14220	COG1403	HNH endonuclease
FRANCCI3_RS14230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRANCCI3_RS14240	COG3842	ATPase activity
FRANCCI3_RS14265	COG0395	ABC-type sugar transport system, permease component
FRANCCI3_RS14275	COG1401	restriction endodeoxyribonuclease activity
FRANCCI3_RS14300	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FRANCCI3_RS14325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRANCCI3_RS14345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRANCCI3_RS14370	COG2018	Roadblock/LC7 domain
FRANCCI3_RS14380	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS14390	COG2733	membrane
FRANCCI3_RS14420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRANCCI3_RS14425	COG0477	Major facilitator Superfamily
FRANCCI3_RS14465	COG0778	Nitroreductase
FRANCCI3_RS14475	COG5464	transposase or invertase
FRANCCI3_RS14480	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FRANCCI3_RS14505	COG0494	nUDIX hydrolase
FRANCCI3_RS14545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRANCCI3_RS14585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS14615	COG4326	sporulation control protein
FRANCCI3_RS14625	COG0657	acetylesterase activity
FRANCCI3_RS14630	COG0367	asparagine synthase
FRANCCI3_RS14635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FRANCCI3_RS14635	COG2308	Evidence 4 Homologs of previously reported genes of
FRANCCI3_RS14650	COG0069	glutamate synthase activity
FRANCCI3_RS14665	COG5650	phosphatidylinositol metabolic process
FRANCCI3_RS14695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FRANCCI3_RS14705	COG2030	dehydratase
FRANCCI3_RS14715	COG0439	Biotin carboxylase
FRANCCI3_RS14720	COG0511	ligase activity, forming carbon-carbon bonds
FRANCCI3_RS14725	COG0825	malonyl-CoA metabolic process
FRANCCI3_RS14725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRANCCI3_RS14730	COG2070	2-Nitropropane dioxygenase
FRANCCI3_RS14730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRANCCI3_RS14800	COG1012	belongs to the aldehyde dehydrogenase family
FRANCCI3_RS14810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRANCCI3_RS14840	COG2815	serine threonine protein kinase
FRANCCI3_RS14840	COG0515	serine threonine protein kinase
FRANCCI3_RS14865	COG1201	RNA secondary structure unwinding
FRANCCI3_RS14895	COG0675	Transposase, IS605 OrfB family
FRANCCI3_RS14940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FRANCCI3_RS14945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FRANCCI3_RS14950	COG1984	allophanate hydrolase subunit 2
FRANCCI3_RS14990	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS14995	COG1132	(ABC) transporter
FRANCCI3_RS15020	COG3773	Cell wall hydrolase
FRANCCI3_RS15020	COG3409	Peptidoglycan-binding domain 1 protein
FRANCCI3_RS15040	COG1228	amidohydrolase
FRANCCI3_RS15050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRANCCI3_RS15070	COG0183	Belongs to the thiolase family
FRANCCI3_RS15080	COG1253	flavin adenine dinucleotide binding
FRANCCI3_RS15100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRANCCI3_RS15140	COG0563	adenylate kinase activity
FRANCCI3_RS15150	COG0067	glutamate synthase
FRANCCI3_RS15150	COG0069	glutamate synthase activity
FRANCCI3_RS15150	COG0070	glutamate synthase
FRANCCI3_RS15155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRANCCI3_RS15160	COG0159	tryptophan synthase activity
FRANCCI3_RS15165	COG0133	tryptophan synthase activity
FRANCCI3_RS15170	COG0134	indole-3-glycerol-phosphate synthase activity
FRANCCI3_RS15185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRANCCI3_RS15190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRANCCI3_RS15195	COG0107	imidazoleglycerol-phosphate synthase activity
FRANCCI3_RS15200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FRANCCI3_RS15205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRANCCI3_RS15210	COG0131	Imidazoleglycerol-phosphate dehydratase
FRANCCI3_RS15215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRANCCI3_RS15220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRANCCI3_RS15230	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS15235	COG2205	protein histidine kinase activity
FRANCCI3_RS15245	COG1959	2 iron, 2 sulfur cluster binding
FRANCCI3_RS15265	COG1737	Transcriptional regulator
FRANCCI3_RS15360	COG0432	Pfam Uncharacterised protein family UPF0047
FRANCCI3_RS15365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FRANCCI3_RS15395	COG1832	CoA-binding protein
FRANCCI3_RS15410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRANCCI3_RS15430	COG0352	thiamine-phosphate diphosphorylase activity
FRANCCI3_RS15445	COG0673	inositol 2-dehydrogenase activity
FRANCCI3_RS15450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRANCCI3_RS15455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRANCCI3_RS15460	COG2022	thiamine diphosphate biosynthetic process
FRANCCI3_RS15465	COG0515	serine threonine protein kinase
FRANCCI3_RS15465	COG2815	serine threonine protein kinase
FRANCCI3_RS15500	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FRANCCI3_RS15505	COG0205	6-phosphofructokinase activity
FRANCCI3_RS15540	COG1940	carbohydrate kinase activity
FRANCCI3_RS15550	COG0003	Pfam Anion-transporting ATPase
FRANCCI3_RS15570	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS15605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRANCCI3_RS15610	COG0723	plastoquinol--plastocyanin reductase activity
FRANCCI3_RS15620	COG1845	cytochrome c oxidase, subunit III
FRANCCI3_RS15635	COG1592	Rubrerythrin
FRANCCI3_RS15650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRANCCI3_RS15660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRANCCI3_RS15665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRANCCI3_RS15670	COG1104	cysteine desulfurase activity
FRANCCI3_RS15680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRANCCI3_RS15690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRANCCI3_RS15700	COG0667	Aldo Keto reductase
FRANCCI3_RS15740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FRANCCI3_RS15745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRANCCI3_RS15750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRANCCI3_RS15755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRANCCI3_RS15760	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRANCCI3_RS15775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRANCCI3_RS15805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRANCCI3_RS15810	COG0174	glutamine synthetase
FRANCCI3_RS15815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRANCCI3_RS15815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRANCCI3_RS15820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRANCCI3_RS15825	COG1309	transcriptional regulator
FRANCCI3_RS15830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRANCCI3_RS15865	COG0494	nUDIX hydrolase
FRANCCI3_RS15870	COG0504	CTP synthase activity
FRANCCI3_RS15875	COG0497	DNA recombination
FRANCCI3_RS15880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRANCCI3_RS15900	COG0647	UMP catabolic process
FRANCCI3_RS15935	COG2094	Belongs to the DNA glycosylase MPG family
FRANCCI3_RS15940	COG0165	Argininosuccinate lyase
FRANCCI3_RS15945	COG0137	argininosuccinate synthase activity
FRANCCI3_RS15955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FRANCCI3_RS15960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRANCCI3_RS15965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRANCCI3_RS15970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRANCCI3_RS15975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FRANCCI3_RS15980	COG0072	phenylalanine-tRNA ligase activity
FRANCCI3_RS15980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRANCCI3_RS15985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRANCCI3_RS15990	COG5002	protein histidine kinase activity
FRANCCI3_RS15995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRANCCI3_RS16000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRANCCI3_RS16005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRANCCI3_RS16010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRANCCI3_RS16030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRANCCI3_RS16035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRANCCI3_RS16035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRANCCI3_RS16045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRANCCI3_RS16055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRANCCI3_RS16065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRANCCI3_RS16075	COG1758	RNA polymerase activity
FRANCCI3_RS16080	COG0194	GDP metabolic process
FRANCCI3_RS16090	COG0284	orotidine-5'-phosphate decarboxylase activity
FRANCCI3_RS16095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRANCCI3_RS16100	COG0505	Belongs to the CarA family
FRANCCI3_RS16110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRANCCI3_RS16115	COG0540	Belongs to the ATCase OTCase family
FRANCCI3_RS16120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRANCCI3_RS16130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRANCCI3_RS16135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRANCCI3_RS16140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FRANCCI3_RS16145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRANCCI3_RS16150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRANCCI3_RS16160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRANCCI3_RS16165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRANCCI3_RS16170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRANCCI3_RS16175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRANCCI3_RS16200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRANCCI3_RS16250	COG3320	Male sterility
FRANCCI3_RS16250	COG1022	Amp-dependent synthetase and ligase
FRANCCI3_RS16270	COG2226	methyltransferase
FRANCCI3_RS16275	COG2409	Drug exporters of the RND superfamily
FRANCCI3_RS16285	COG0494	nUDIX hydrolase
FRANCCI3_RS16300	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS16320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS16335	COG5634	Uncharacterized conserved protein (DUF2278)
FRANCCI3_RS16375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRANCCI3_RS16380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRANCCI3_RS16380	COG0515	serine threonine protein kinase
FRANCCI3_RS16390	COG2755	lipolytic protein G-D-S-L family
FRANCCI3_RS16390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FRANCCI3_RS16395	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FRANCCI3_RS16395	COG4124	Belongs to the glycosyl hydrolase 26 family
FRANCCI3_RS16425	COG0675	Transposase, IS605 OrfB family
FRANCCI3_RS16455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRANCCI3_RS16470	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS16500	COG0318	PFAM AMP-dependent synthetase and ligase
FRANCCI3_RS16515	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FRANCCI3_RS16525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRANCCI3_RS16545	COG2002	toxin-antitoxin pair type II binding
FRANCCI3_RS16555	COG1733	regulation of RNA biosynthetic process
FRANCCI3_RS16680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS16780	COG4962	Type ii secretion system protein e
FRANCCI3_RS16865	COG1518	maintenance of DNA repeat elements
FRANCCI3_RS16870	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FRANCCI3_RS16875	COG0582	viral genome integration into host DNA
FRANCCI3_RS16890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FRANCCI3_RS16960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRANCCI3_RS16980	COG1032	radical SAM domain protein
FRANCCI3_RS17020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRANCCI3_RS17025	COG0602	queuosine metabolic process
FRANCCI3_RS17030	COG0720	synthase
FRANCCI3_RS17040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FRANCCI3_RS17060	COG0582	viral genome integration into host DNA
FRANCCI3_RS17110	COG0515	serine threonine protein kinase
FRANCCI3_RS17110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRANCCI3_RS17175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRANCCI3_RS17185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRANCCI3_RS17230	COG2267	carboxylic ester hydrolase activity
FRANCCI3_RS17235	COG0667	Aldo Keto reductase
FRANCCI3_RS17280	COG1024	Enoyl-CoA hydratase
FRANCCI3_RS17345	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS17350	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS17365	COG0475	glutathione-regulated potassium exporter activity
FRANCCI3_RS17370	COG0039	L-malate dehydrogenase activity
FRANCCI3_RS17405	COG1643	Atp-dependent helicase
FRANCCI3_RS17420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FRANCCI3_RS17430	COG0789	Transcriptional regulator
FRANCCI3_RS17435	COG0431	NADPH-dependent FMN reductase
FRANCCI3_RS17445	COG0411	ABC transporter
FRANCCI3_RS17450	COG2340	Cysteine-rich secretory protein family
FRANCCI3_RS17465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FRANCCI3_RS17490	COG0583	DNA-binding transcription factor activity
FRANCCI3_RS17500	COG1053	succinate dehydrogenase
FRANCCI3_RS17505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRANCCI3_RS17515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FRANCCI3_RS17520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRANCCI3_RS17530	COG0489	protein tyrosine kinase activity
FRANCCI3_RS17535	COG1086	Polysaccharide biosynthesis protein
FRANCCI3_RS17540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRANCCI3_RS17550	COG2365	Tyrosine phosphatase family
FRANCCI3_RS17560	COG2501	S4 domain
FRANCCI3_RS17575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRANCCI3_RS17580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRANCCI3_RS17600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRANCCI3_RS17620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRANCCI3_RS17645	COG1316	TRANSCRIPTIONal
FRANCCI3_RS17650	COG0006	proline dipeptidase activity
FRANCCI3_RS17665	COG1119	ATPase activity
FRANCCI3_RS17680	COG0123	including yeast histone deacetylase and acetoin utilization protein
FRANCCI3_RS17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRANCCI3_RS17690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRANCCI3_RS17700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRANCCI3_RS17705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRANCCI3_RS17715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FRANCCI3_RS17720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRANCCI3_RS17735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FRANCCI3_RS17745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRANCCI3_RS17755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRANCCI3_RS17760	COG1126	abc transporter atp-binding protein
FRANCCI3_RS17765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRANCCI3_RS17770	COG0765	amino acid transport
FRANCCI3_RS17775	COG0765	amino acid transport
FRANCCI3_RS17780	COG1418	mRNA catabolic process
FRANCCI3_RS17785	COG2137	regulation of response to DNA damage stimulus
FRANCCI3_RS17790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRANCCI3_RS17800	COG1201	RNA secondary structure unwinding
FRANCCI3_RS17835	COG1842	Phage shock protein A
FRANCCI3_RS17850	COG1396	sequence-specific DNA binding
FRANCCI3_RS17855	COG1058	Belongs to the CinA family
FRANCCI3_RS17855	COG1546	Belongs to the CinA family
FRANCCI3_RS17865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRANCCI3_RS17875	COG1674	ftsk spoiiie
FRANCCI3_RS17880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FRANCCI3_RS17885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRANCCI3_RS17890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRANCCI3_RS17905	COG0124	histidyl-tRNA synthetase
FRANCCI3_RS17910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FRANCCI3_RS17915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRANCCI3_RS17925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRANCCI3_RS17940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRANCCI3_RS17945	COG0612	Peptidase, M16
FRANCCI3_RS17950	COG1185	polyribonucleotide nucleotidyltransferase activity
FRANCCI3_RS17955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRANCCI3_RS17960	COG0196	riboflavin kinase activity
FRANCCI3_RS17965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRANCCI3_RS17970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FRANCCI3_RS17975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRANCCI3_RS17985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRANCCI3_RS17995	COG0779	Required for maturation of 30S ribosomal subunits
FRANCCI3_RS18010	COG1959	2 iron, 2 sulfur cluster binding
FRANCCI3_RS18015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRANCCI3_RS18035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRANCCI3_RS18055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FRANCCI3_RS18065	COG0233	cytoplasmic translational termination
FRANCCI3_RS18070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRANCCI3_RS18075	COG0052	Belongs to the universal ribosomal protein uS2 family
FRANCCI3_RS18085	COG4974	Belongs to the 'phage' integrase family
FRANCCI3_RS18100	COG0792	nuclease activity
FRANCCI3_RS18110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRANCCI3_RS18120	COG0335	large ribosomal subunit rRNA binding
FRANCCI3_RS18125	COG0336	Belongs to the RNA methyltransferase TrmD family
FRANCCI3_RS18130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRANCCI3_RS18135	COG1837	Belongs to the UPF0109 family
FRANCCI3_RS18140	COG0228	four-way junction DNA binding
FRANCCI3_RS18155	COG1196	nuclear chromosome segregation
FRANCCI3_RS18165	COG1254	Belongs to the acylphosphatase family
FRANCCI3_RS18175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRANCCI3_RS18180	COG0571	ribonuclease III activity
FRANCCI3_RS18185	COG0416	fatty acid biosynthetic process
FRANCCI3_RS18190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRANCCI3_RS18200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRANCCI3_RS18205	COG0742	ribosomal rna small subunit methyltransferase
FRANCCI3_RS18210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRANCCI3_RS18215	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRANCCI3_RS18230	COG0351	phosphomethylpyrimidine kinase
FRANCCI3_RS18235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRANCCI3_RS18240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRANCCI3_RS18250	COG1920	GTP binding
FRANCCI3_RS18260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FRANCCI3_RS18265	COG0776	regulation of translation
FRANCCI3_RS18270	COG0066	3-isopropylmalate dehydratase activity
FRANCCI3_RS18275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRANCCI3_RS18280	COG1414	Transcriptional regulator
FRANCCI3_RS18285	COG0515	serine threonine protein kinase
FRANCCI3_RS18290	COG2205	protein histidine kinase activity
FRANCCI3_RS18320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRANCCI3_RS18340	COG0473	3-isopropylmalate dehydrogenase activity
FRANCCI3_RS18345	COG3287	FIST C domain
FRANCCI3_RS18345	COG2200	EAL domain
FRANCCI3_RS18345	COG2199	diguanylate cyclase activity
FRANCCI3_RS18355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRANCCI3_RS18370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRANCCI3_RS18375	COG0440	acetolactate synthase activity
FRANCCI3_RS18390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRANCCI3_RS18400	COG0154	amidase activity
FRANCCI3_RS18405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRANCCI3_RS18415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRANCCI3_RS18425	COG0482	sulfurtransferase activity
FRANCCI3_RS18440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRANCCI3_RS18440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRANCCI3_RS18440	COG1703	isobutyryl-CoA mutase activity
FRANCCI3_RS18460	COG1940	carbohydrate kinase activity
FRANCCI3_RS18485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FRANCCI3_RS18510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRANCCI3_RS18515	COG0058	SHG alpha-glucan phosphorylase activity
FRANCCI3_RS18585	COG0366	Alpha amylase catalytic
FRANCCI3_RS18595	COG3281	Trehalose synthase
FRANCCI3_RS18600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FRANCCI3_RS18615	COG5002	protein histidine kinase activity
FRANCCI3_RS18615	COG0784	Response regulator, receiver
FRANCCI3_RS18625	COG0183	Belongs to the thiolase family
FRANCCI3_RS18660	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FRANCCI3_RS18665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRANCCI3_RS18685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRANCCI3_RS18690	COG1051	belongs to the nudix hydrolase family
FRANCCI3_RS18720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRANCCI3_RS18725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRANCCI3_RS18730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRANCCI3_RS18735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRANCCI3_RS18740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRANCCI3_RS18745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRANCCI3_RS18750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRANCCI3_RS18755	COG0356	it plays a direct role in the translocation of protons across the membrane
FRANCCI3_RS18775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRANCCI3_RS18780	COG0009	L-threonylcarbamoyladenylate synthase
FRANCCI3_RS18785	COG2890	protein-(glutamine-N5) methyltransferase activity
FRANCCI3_RS18790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRANCCI3_RS18795	COG0254	rRNA binding
FRANCCI3_RS18805	COG0083	homoserine kinase activity
FRANCCI3_RS18810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRANCCI3_RS18815	COG0460	homoserine dehydrogenase
FRANCCI3_RS18820	COG0019	diaminopimelate decarboxylase activity
FRANCCI3_RS18825	COG0018	arginyl-trna synthetase
FRANCCI3_RS18830	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS18895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRANCCI3_RS18900	COG0156	8-amino-7-oxononanoate synthase activity
FRANCCI3_RS18905	COG0500	methyltransferase
FRANCCI3_RS18930	COG0567	Dehydrogenase, E1 component
FRANCCI3_RS18930	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRANCCI3_RS18940	COG0604	alcohol dehydrogenase
FRANCCI3_RS18955	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FRANCCI3_RS18965	COG2172	sigma factor antagonist activity
FRANCCI3_RS18970	COG1191	sigma factor activity
FRANCCI3_RS18980	COG1597	lipid kinase activity
FRANCCI3_RS19000	COG0156	8-amino-7-oxononanoate synthase activity
FRANCCI3_RS19005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FRANCCI3_RS19010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRANCCI3_RS19020	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FRANCCI3_RS19030	COG5662	AntiSigma factor
FRANCCI3_RS19035	COG1595	DNA-templated transcription, initiation
FRANCCI3_RS19060	COG0483	inositol monophosphate 1-phosphatase activity
FRANCCI3_RS19080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRANCCI3_RS19085	COG1522	sequence-specific DNA binding
FRANCCI3_RS19100	COG1615	UPF0182 protein
FRANCCI3_RS19110	COG3480	Lon protease (S16) C-terminal proteolytic domain
FRANCCI3_RS19120	COG0314	molybdopterin synthase activity
FRANCCI3_RS19135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRANCCI3_RS19170	COG0612	Peptidase, M16
FRANCCI3_RS19175	COG0612	Peptidase, M16
FRANCCI3_RS19180	COG3835	regulator
FRANCCI3_RS19190	COG0210	DNA helicase
FRANCCI3_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS19220	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FRANCCI3_RS19245	COG0513	Belongs to the DEAD box helicase family
FRANCCI3_RS19290	COG2239	Acts as a magnesium transporter
FRANCCI3_RS19305	COG3540	Alkaline phosphatase
FRANCCI3_RS19310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRANCCI3_RS19330	COG1012	belongs to the aldehyde dehydrogenase family
FRANCCI3_RS19335	COG0613	PHP domain protein
FRANCCI3_RS19350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRANCCI3_RS19355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRANCCI3_RS19370	COG1595	DNA-templated transcription, initiation
FRANCCI3_RS19385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRANCCI3_RS19395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRANCCI3_RS19400	COG1611	Belongs to the LOG family
FRANCCI3_RS19405	COG1611	Belongs to the LOG family
FRANCCI3_RS19410	COG1045	serine acetyltransferase
FRANCCI3_RS19440	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS19455	COG0438	transferase activity, transferring glycosyl groups
FRANCCI3_RS19470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRANCCI3_RS19475	COG2171	N-acyltransferase activity
FRANCCI3_RS19485	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRANCCI3_RS19505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRANCCI3_RS19510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FRANCCI3_RS19515	COG1217	gtp-binding protein TYPA
FRANCCI3_RS19520	COG2816	NAD+ diphosphatase activity
FRANCCI3_RS19525	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRANCCI3_RS19545	COG0012	GTP binding
FRANCCI3_RS19585	COG1722	exodeoxyribonuclease VII activity
FRANCCI3_RS19590	COG1570	exodeoxyribonuclease VII activity
FRANCCI3_RS19595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRANCCI3_RS19600	COG0114	fumarate hydratase activity
FRANCCI3_RS19610	COG1733	regulation of RNA biosynthetic process
FRANCCI3_RS19625	COG0563	adenylate kinase activity
FRANCCI3_RS19655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRANCCI3_RS19660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FRANCCI3_RS19665	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FRANCCI3_RS19680	COG1331	Highly conserved protein containing a thioredoxin domain
FRANCCI3_RS19685	COG0495	leucyl-tRNA aminoacylation
FRANCCI3_RS19695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FRANCCI3_RS19700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRANCCI3_RS19755	COG3467	pyridoxamine 5'-phosphate
FRANCCI3_RS19770	COG1252	NADH dehydrogenase
FRANCCI3_RS19795	COG0148	phosphopyruvate hydratase activity
FRANCCI3_RS19800	COG0616	signal peptide processing
FRANCCI3_RS19805	COG0789	Transcriptional regulator
FRANCCI3_RS19825	COG4124	Belongs to the glycosyl hydrolase 26 family
FRANCCI3_RS19830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRANCCI3_RS19835	COG4310	Domain of unknown function (DUF2172)
FRANCCI3_RS19840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRANCCI3_RS19840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRANCCI3_RS19850	COG4221	oxidoreductase activity
FRANCCI3_RS19880	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FRANCCI3_RS19905	COG1404	Belongs to the peptidase S8 family
FRANCCI3_RS19910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRANCCI3_RS19935	COG0193	aminoacyl-tRNA hydrolase activity
FRANCCI3_RS19940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRANCCI3_RS19975	COG1302	Protein conserved in bacteria
FRANCCI3_RS19980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRANCCI3_RS19985	COG0488	(ABC) transporter
FRANCCI3_RS20000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRANCCI3_RS20005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRANCCI3_RS20015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRANCCI3_RS20020	COG0084	hydrolase, TatD family'
FRANCCI3_RS20060	COG3387	PFAM Glycoside hydrolase 15-related
FRANCCI3_RS20075	COG0659	secondary active sulfate transmembrane transporter activity
FRANCCI3_RS20230	COG1959	2 iron, 2 sulfur cluster binding
FRANCCI3_RS20235	COG2814	Major facilitator Superfamily
FRANCCI3_RS20260	COG3293	Transposase
FRANCCI3_RS20270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRANCCI3_RS20320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRANCCI3_RS20335	COG2197	response regulator
FRANCCI3_RS20340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRANCCI3_RS20345	COG2197	response regulator
FRANCCI3_RS20390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRANCCI3_RS20395	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRANCCI3_RS20395	COG0315	cyclic pyranopterin monophosphate synthase activity
FRANCCI3_RS20400	COG0315	cyclic pyranopterin monophosphate synthase activity
FRANCCI3_RS20410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRANCCI3_RS20415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRANCCI3_RS20435	COG1937	Protein conserved in bacteria
FRANCCI3_RS20455	COG3850	Histidine kinase
FRANCCI3_RS20455	COG3437	response regulator, receiver
FRANCCI3_RS20455	COG4999	Histidine kinase
FRANCCI3_RS20455	COG2205	protein histidine kinase activity
FRANCCI3_RS20475	COG0019	diaminopimelate decarboxylase activity
FRANCCI3_RS20505	COG0174	glutamine synthetase
FRANCCI3_RS20510	COG2409	Drug exporters of the RND superfamily
FRANCCI3_RS20525	COG3706	GGDEF domain
FRANCCI3_RS20535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRANCCI3_RS20535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRANCCI3_RS20560	COG0515	serine threonine protein kinase
FRANCCI3_RS20565	COG0714	Associated with various cellular activities
FRANCCI3_RS20615	COG0587	DNA-directed DNA polymerase activity
FRANCCI3_RS20655	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRANCCI3_RS20675	COG0494	nUDIX hydrolase
FRANCCI3_RS20710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRANCCI3_RS20715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRANCCI3_RS20725	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS20800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRANCCI3_RS20830	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS20880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRANCCI3_RS20905	COG0300	oxidoreductase activity
FRANCCI3_RS20910	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRANCCI3_RS20925	COG1960	acyl-CoA dehydrogenase activity
FRANCCI3_RS20955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRANCCI3_RS20985	COG0477	Major facilitator Superfamily
FRANCCI3_RS21055	COG0431	NADPH-dependent FMN reductase
FRANCCI3_RS21075	COG0587	DNA-directed DNA polymerase activity
FRANCCI3_RS21085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRANCCI3_RS21150	COG1595	DNA-templated transcription, initiation
FRANCCI3_RS21155	COG4249	Peptidase C14 caspase catalytic subunit p20
FRANCCI3_RS21155	COG2319	Wd-40 repeat
FRANCCI3_RS21170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRANCCI3_RS21175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FRANCCI3_RS21190	COG3293	Transposase
FRANCCI3_RS21240	COG1131	(ABC) transporter
FRANCCI3_RS21250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS21275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS21285	COG2826	transposase and inactivated derivatives, IS30 family
FRANCCI3_RS21305	COG3385	transposase activity
FRANCCI3_RS21315	COG3547	Transposase (IS116 IS110 IS902 family)
FRANCCI3_RS21380	COG3293	Transposase
FRANCCI3_RS21395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRANCCI3_RS21440	COG1120	ATPase activity
FRANCCI3_RS21445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRANCCI3_RS21450	COG1132	(ABC) transporter
FRANCCI3_RS21495	COG0215	cysteine-tRNA ligase activity
FRANCCI3_RS21505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRANCCI3_RS21510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRANCCI3_RS21515	COG1329	Transcriptional regulator
FRANCCI3_RS21525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRANCCI3_RS21530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FRANCCI3_RS21535	COG1194	a g-specific adenine glycosylase
FRANCCI3_RS21545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRANCCI3_RS21560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRANCCI3_RS21570	COG0442	prolyl-tRNA aminoacylation
FRANCCI3_RS21575	COG0528	UMP kinase activity
FRANCCI3_RS21585	COG2188	Transcriptional regulator
FRANCCI3_RS21620	COG1408	metallophosphoesterase
FRANCCI3_RS21625	COG1610	YqeY-like protein
FRANCCI3_RS21630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRANCCI3_RS21660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRANCCI3_RS21700	COG0596	Alpha beta hydrolase
FRANCCI3_RS21745	COG1205	dead DEAH box helicase
FRANCCI3_RS21745	COG1111	helicase
FRANCCI3_RS21750	COG1366	Belongs to the anti-sigma-factor antagonist family
FRANCCI3_RS21760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FRANCCI3_RS21765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRANCCI3_RS21765	COG1754	DNA topoisomerase type I activity
FRANCCI3_RS21775	COG0470	DNA polymerase III
FRANCCI3_RS21780	COG1774	PSP1 C-terminal conserved region
FRANCCI3_RS21785	COG0745	RESPONSE REGULATOR receiver
FRANCCI3_RS21795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRANCCI3_RS21805	COG2027	D-alanyl-D-alanine carboxypeptidase
FRANCCI3_RS21815	COG0037	tRNA processing
FRANCCI3_RS21825	COG0302	gtp cyclohydrolase
FRANCCI3_RS21830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRANCCI3_RS21835	COG0140	phosphoribosyl-ATP diphosphatase activity
FRANCCI3_RS21840	COG0561	phosphatase activity
FRANCCI3_RS21925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRANCCI3_RS22010	COG0717	Belongs to the dCTP deaminase family
FRANCCI3_RS22015	COG0247	lactate metabolic process
FRANCCI3_RS22015	COG2181	nitrate reductase activity
FRANCCI3_RS22025	COG0443	Heat shock 70 kDa protein
FRANCCI3_RS22030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRANCCI3_RS22035	COG0484	heat shock protein binding
FRANCCI3_RS22040	COG0789	Transcriptional regulator
FRANCCI3_RS22045	COG0542	response to heat
FRANCCI3_RS22080	COG0586	Pfam SNARE associated Golgi protein
FRANCCI3_RS22090	COG1388	LysM domain
FRANCCI3_RS22095	COG1652	LysM domain
FRANCCI3_RS22105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRANCCI3_RS22120	COG0151	Belongs to the GarS family
FRANCCI3_RS22130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRANCCI3_RS22135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRANCCI3_RS22145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRANCCI3_RS22150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FRANCCI3_RS22155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FRANCCI3_RS22165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRANCCI3_RS22215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRANCCI3_RS22240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRANCCI3_RS22250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRANCCI3_RS22255	COG0459	protein refolding
FRANCCI3_RS22290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FRANCCI3_RS22330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRANCCI3_RS22330	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FRANCCI3_RS22340	COG0047	phosphoribosylformylglycinamidine synthase activity
FRANCCI3_RS22345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRANCCI3_RS22355	COG2814	Major facilitator Superfamily
FRANCCI3_RS22365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRANCCI3_RS22370	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FRANCCI3_RS22375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRANCCI3_RS22395	COG1278	Cold shock
FRANCCI3_RS22410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRANCCI3_RS22420	COG1716	ATPase activity
FRANCCI3_RS22425	COG1716	ATPase activity
FRANCCI3_RS22440	COG0768	penicillin binding
FRANCCI3_RS22445	COG0515	serine threonine protein kinase
FRANCCI3_RS22450	COG0515	serine threonine protein kinase
FRANCCI3_RS22480	COG3387	PFAM Glycoside hydrolase 15-related
FRANCCI3_RS22530	COG0183	Belongs to the thiolase family
FRANCCI3_RS22545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRANCCI3_RS22560	COG1929	Belongs to the glycerate kinase type-1 family
FRANCCI3_RS22565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRANCCI3_RS22570	COG1968	undecaprenyl-diphosphatase activity
FRANCCI3_RS22590	COG2124	cytochrome p450
FRANCCI3_RS22605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS22610	COG1278	Cold shock
FRANCCI3_RS22615	COG0784	Response regulator, receiver
FRANCCI3_RS22630	COG1013	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS22635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FRANCCI3_RS22635	COG0674	pyruvate-flavodoxin oxidoreductase activity
FRANCCI3_RS22645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRANCCI3_RS22690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRANCCI3_RS22705	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FRANCCI3_RS22750	COG0543	2 iron, 2 sulfur cluster binding
FRANCCI3_RS22755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRANCCI3_RS22755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRANCCI3_RS22770	COG0517	IMP dehydrogenase activity
FRANCCI3_RS22800	COG1192	Involved in chromosome partitioning
FRANCCI3_RS22825	COG3572	ergothioneine biosynthetic process
FRANCCI3_RS22830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRANCCI3_RS22840	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FRANCCI3_RS22845	COG0129	dihydroxy-acid dehydratase activity
FRANCCI3_RS22860	COG0305	Participates in initiation and elongation during chromosome replication
FRANCCI3_RS22865	COG0359	binds to the 23S rRNA
FRANCCI3_RS22870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRANCCI3_RS22880	COG0360	Binds together with S18 to 16S ribosomal RNA
FRANCCI3_RS22900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRANCCI3_RS22925	COG0617	tRNA 3'-terminal CCA addition
FRANCCI3_RS22945	COG2815	serine threonine protein kinase
FRANCCI3_RS22945	COG0515	serine threonine protein kinase
FRANCCI3_RS22960	COG0492	ferredoxin-NADP+ reductase activity
FRANCCI3_RS22965	COG3118	belongs to the thioredoxin family
FRANCCI3_RS22970	COG3409	Peptidoglycan-binding domain 1 protein
FRANCCI3_RS22970	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRANCCI3_RS22985	COG1192	Involved in chromosome partitioning
FRANCCI3_RS22990	COG0357	Ribosomal RNA small subunit methyltransferase G
FRANCCI3_RS23000	COG1847	R3H domain protein
FRANCCI3_RS23005	COG0706	membrane insertase activity
FRANCCI3_RS23010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FRANCCI3_RS23015	COG0594	ribonuclease P activity
FRANCCI3_RS23075	COG0484	heat shock protein binding
FRANCCI3_RS23080	COG0174	glutamine synthetase
FRANCCI3_RS23095	COG4974	Belongs to the 'phage' integrase family
FRANCCI3_RS23150	COG1309	transcriptional regulator
FRANCCI3_RS23155	COG3903	Transcriptional regulator
FRANCCI3_RS23155	COG3629	intracellular signal transduction
FRANCCI3_RS23180	COG3290	protein histidine kinase activity
FRANCCI3_RS23215	COG0604	alcohol dehydrogenase
FRANCCI3_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
FRANCCI3_RS23215	COG3321	synthase
FRANCCI3_RS23225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRANCCI3_RS23260	COG3903	Transcriptional regulator
FRANCCI3_RS23260	COG3629	intracellular signal transduction
FRANCCI3_RS23285	COG2197	response regulator
FRANCCI3_RS23320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRANCCI3_RS23320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRANCCI3_RS23385	COG5433	transposase activity
FRANCCI3_RS23400	COG0515	serine threonine protein kinase
FRANCCI3_RS23405	COG0589	response to stress
FRANCCI3_RS23405	COG0589	response to stress
FRANCCI3_RS23410	COG4251	negative regulation of phosphorylation
FRANCCI3_RS23430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRANCCI3_RS23485	COG3284	Transcriptional regulator
FRANCCI3_RS23590	COG1438	arginine binding
FRANCCI3_RS23705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases