locus-tag	class	description
FRAAU_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRAAU_RS00010	COG0592	DNA-directed DNA polymerase activity
FRAAU_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRAAU_RS00020	COG0187	DNA topoisomerase II activity
FRAAU_RS00080	COG1725	Transcriptional regulator
FRAAU_RS00090	COG3387	PFAM Glycoside hydrolase 15-related
FRAAU_RS00095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FRAAU_RS00100	COG1070	Carbohydrate kinase
FRAAU_RS00105	COG0738	Major facilitator superfamily
FRAAU_RS00120	COG3047	cAMP biosynthetic process
FRAAU_RS00160	COG0628	permease
FRAAU_RS00165	COG1968	undecaprenyl-diphosphatase activity
FRAAU_RS00175	COG0739	heme binding
FRAAU_RS00180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRAAU_RS00255	COG0708	Exodeoxyribonuclease III
FRAAU_RS00265	COG2706	6-phosphogluconolactonase activity
FRAAU_RS00285	COG0697	spore germination
FRAAU_RS00300	COG0477	Major facilitator Superfamily
FRAAU_RS00305	COG0800	Aldolase
FRAAU_RS00310	COG0129	dihydroxy-acid dehydratase activity
FRAAU_RS00315	COG0363	glucosamine-6-phosphate deaminase activity
FRAAU_RS00320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FRAAU_RS00325	COG2188	Transcriptional regulator
FRAAU_RS00395	COG0463	Glycosyl transferase, family 2
FRAAU_RS00405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRAAU_RS00425	COG0640	Transcriptional regulator
FRAAU_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS00435	COG0588	phosphoglycerate mutase activity
FRAAU_RS00450	COG0606	chelatase, subunit chli
FRAAU_RS00465	COG2224	Isocitrate lyase
FRAAU_RS00470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRAAU_RS00475	COG0583	DNA-binding transcription factor activity
FRAAU_RS00485	COG0538	isocitrate dehydrogenase activity
FRAAU_RS00490	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FRAAU_RS00505	COG0583	DNA-binding transcription factor activity
FRAAU_RS00525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRAAU_RS00530	COG1459	type II secretion system
FRAAU_RS00535	COG2165	general secretion pathway protein
FRAAU_RS00560	COG3166	PFAM Fimbrial assembly family protein
FRAAU_RS00575	COG1450	Type ii and iii secretion system protein
FRAAU_RS00585	COG1643	Atp-dependent helicase
FRAAU_RS00590	COG3135	benzoate transporter
FRAAU_RS00600	COG4774	siderophore transport
FRAAU_RS00605	COG4774	siderophore transport
FRAAU_RS00615	COG0589	response to stress
FRAAU_RS00640	COG1111	helicase
FRAAU_RS00640	COG1205	dead DEAH box helicase
FRAAU_RS00650	COG3122	Protein conserved in bacteria
FRAAU_RS00655	COG0667	Aldo Keto reductase
FRAAU_RS00660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRAAU_RS00670	COG0318	PFAM AMP-dependent synthetase and ligase
FRAAU_RS00700	COG2134	cdp-diacylglycerol pyrophosphatase
FRAAU_RS00705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRAAU_RS00715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FRAAU_RS00730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRAAU_RS00735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRAAU_RS00800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRAAU_RS00805	COG3240	lipase activity
FRAAU_RS00805	COG4625	pathogenesis
FRAAU_RS00810	COG2183	response to ionizing radiation
FRAAU_RS00825	COG0308	aminopeptidase N
FRAAU_RS00835	COG0519	Catalyzes the synthesis of GMP from XMP
FRAAU_RS00840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FRAAU_RS00845	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS00860	COG1054	Belongs to the UPF0176 family
FRAAU_RS00865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRAAU_RS00870	COG0156	8-amino-7-oxononanoate synthase activity
FRAAU_RS00875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRAAU_RS00885	COG1040	competence protein
FRAAU_RS00930	COG4964	Belongs to the GSP D family
FRAAU_RS00960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRAAU_RS00965	COG0720	synthase
FRAAU_RS00975	COG0356	it plays a direct role in the translocation of protons across the membrane
FRAAU_RS00985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRAAU_RS00990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRAAU_RS00995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRAAU_RS01005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRAAU_RS01020	COG1846	Transcriptional regulator
FRAAU_RS01025	COG1741	Belongs to the pirin family
FRAAU_RS01035	COG0612	Peptidase, M16
FRAAU_RS01050	COG2188	Transcriptional regulator
FRAAU_RS01075	COG0625	glutathione transferase activity
FRAAU_RS01085	COG3189	MarR family transcriptional regulator
FRAAU_RS01105	COG0747	negative chemotaxis
FRAAU_RS01115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRAAU_RS01120	COG4172	Belongs to the ABC transporter superfamily
FRAAU_RS01125	COG3829	transcription factor binding
FRAAU_RS01140	COG0431	NADPH-dependent FMN reductase
FRAAU_RS01180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRAAU_RS01190	COG0582	viral genome integration into host DNA
FRAAU_RS01205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRAAU_RS01210	COG1490	D-aminoacyl-tRNA deacylase activity
FRAAU_RS01225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRAAU_RS01245	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS01250	COG1216	Glycosyl transferase, family 2
FRAAU_RS01260	COG2199	diguanylate cyclase activity
FRAAU_RS01260	COG2202	Pas domain
FRAAU_RS01260	COG2200	EAL domain
FRAAU_RS01280	COG0300	oxidoreductase activity
FRAAU_RS01285	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FRAAU_RS01295	COG2982	Protein involved in outer membrane biogenesis
FRAAU_RS01300	COG0552	protein localization to endoplasmic reticulum
FRAAU_RS01305	COG0742	ribosomal rna small subunit methyltransferase
FRAAU_RS01320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRAAU_RS01340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRAAU_RS01340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRAAU_RS01380	COG3161	chorismate lyase activity
FRAAU_RS01390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRAAU_RS01395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FRAAU_RS01420	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FRAAU_RS01450	COG3631	Ketosteroid isomerase-related protein
FRAAU_RS01465	COG0583	DNA-binding transcription factor activity
FRAAU_RS01470	COG2226	methyltransferase
FRAAU_RS01505	COG0545	Peptidyl-prolyl cis-trans isomerase
FRAAU_RS01530	COG2837	iron assimilation
FRAAU_RS01540	COG2186	Transcriptional regulator
FRAAU_RS01545	COG2721	sulfolactate sulfo-lyase activity
FRAAU_RS01555	COG1113	amino acid transport
FRAAU_RS01560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRAAU_RS01565	COG2733	membrane
FRAAU_RS01570	COG0668	transmembrane transport
FRAAU_RS01610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FRAAU_RS01625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FRAAU_RS01640	COG2814	Major facilitator Superfamily
FRAAU_RS01655	COG0642	Histidine kinase
FRAAU_RS01660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRAAU_RS01665	COG1819	glycosyl
FRAAU_RS01680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRAAU_RS01710	COG1335	isochorismatase
FRAAU_RS01715	COG1621	beta-fructofuranosidase activity
FRAAU_RS01720	COG0656	L-ascorbic acid biosynthetic process
FRAAU_RS01725	COG0488	(ABC) transporter
FRAAU_RS01735	COG1070	Carbohydrate kinase
FRAAU_RS01740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FRAAU_RS01755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRAAU_RS01765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FRAAU_RS01770	COG1280	lysine exporter protein (LysE YggA)
FRAAU_RS01780	COG3107	peptidoglycan biosynthetic process
FRAAU_RS01795	COG0275	rRNA processing
FRAAU_RS01800	COG3116	cell division
FRAAU_RS01815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRAAU_RS01820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRAAU_RS01830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRAAU_RS01835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRAAU_RS01840	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRAAU_RS01845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRAAU_RS01860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FRAAU_RS01875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRAAU_RS01880	COG2967	ApaG domain
FRAAU_RS01890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRAAU_RS01895	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FRAAU_RS01905	COG2096	Adenosyltransferase
FRAAU_RS01910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRAAU_RS01915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRAAU_RS01925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRAAU_RS01940	COG0469	pyruvate kinase activity
FRAAU_RS01950	COG3588	fructose-bisphosphate aldolase
FRAAU_RS01975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRAAU_RS01995	COG0006	proline dipeptidase activity
FRAAU_RS02005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRAAU_RS02010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRAAU_RS02015	COG1024	Enoyl-CoA hydratase
FRAAU_RS02020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FRAAU_RS02025	COG1561	YicC-like family, N-terminal region
FRAAU_RS02035	COG1127	ABC transporter
FRAAU_RS02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRAAU_RS02045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FRAAU_RS02065	COG1758	RNA polymerase activity
FRAAU_RS02070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRAAU_RS02075	COG2951	lytic endotransglycosylase activity
FRAAU_RS02090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FRAAU_RS02095	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FRAAU_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS02115	COG0754	glutathionylspermidine amidase activity
FRAAU_RS02135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRAAU_RS02135	COG0543	2 iron, 2 sulfur cluster binding
FRAAU_RS02145	COG0242	peptide deformylase activity
FRAAU_RS02155	COG2252	PERMEase
FRAAU_RS02175	COG0284	orotidine-5'-phosphate decarboxylase activity
FRAAU_RS02180	COG0488	(ABC) transporter
FRAAU_RS02195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRAAU_RS02200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRAAU_RS02205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRAAU_RS02205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRAAU_RS02230	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRAAU_RS02235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRAAU_RS02245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRAAU_RS02255	COG0667	Aldo Keto reductase
FRAAU_RS02270	COG1538	Outer membrane efflux protein
FRAAU_RS02280	COG1136	(ABC) transporter
FRAAU_RS02285	COG0577	efflux transmembrane transporter activity
FRAAU_RS02285	COG1136	(ABC) transporter
FRAAU_RS02290	COG1136	(ABC) transporter
FRAAU_RS02290	COG0577	efflux transmembrane transporter activity
FRAAU_RS02300	COG0577	efflux transmembrane transporter activity
FRAAU_RS02305	COG1136	(ABC) transporter
FRAAU_RS02305	COG0577	efflux transmembrane transporter activity
FRAAU_RS02310	COG2204	response regulator
FRAAU_RS02325	COG0330	HflC and HflK could
FRAAU_RS02345	COG0442	prolyl-tRNA aminoacylation
FRAAU_RS02350	COG1183	phosphatidylcholine synthase activity
FRAAU_RS02360	COG0456	acetyltransferase
FRAAU_RS02375	COG2353	YceI-like domain
FRAAU_RS02400	COG0438	transferase activity, transferring glycosyl groups
FRAAU_RS02410	COG1560	Kdo2-lipid A biosynthetic process
FRAAU_RS02415	COG1519	Transferase
FRAAU_RS02420	COG1538	Outer membrane efflux protein
FRAAU_RS02425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRAAU_RS02445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRAAU_RS02505	COG0563	adenylate kinase activity
FRAAU_RS02510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRAAU_RS02520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRAAU_RS02530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRAAU_RS02535	COG1773	rubredoxin
FRAAU_RS02575	COG0501	Belongs to the peptidase M48B family
FRAAU_RS02580	COG0326	Molecular chaperone. Has ATPase activity
FRAAU_RS02595	COG2132	Multicopper oxidase
FRAAU_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS02635	COG0753	catalase activity
FRAAU_RS02640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FRAAU_RS02645	COG0830	nickel cation binding
FRAAU_RS02650	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FRAAU_RS02655	COG0804	urea catabolic process
FRAAU_RS02660	COG0832	Belongs to the urease beta subunit family
FRAAU_RS02665	COG0831	urea catabolic process
FRAAU_RS02670	COG0829	nickel cation binding
FRAAU_RS02675	COG0166	Belongs to the GPI family
FRAAU_RS02680	COG0659	secondary active sulfate transmembrane transporter activity
FRAAU_RS02685	COG2814	Major facilitator Superfamily
FRAAU_RS02690	COG0583	DNA-binding transcription factor activity
FRAAU_RS02700	COG0166	Belongs to the GPI family
FRAAU_RS02705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRAAU_RS02710	COG3590	peptidase
FRAAU_RS02715	COG0210	DNA helicase
FRAAU_RS02720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRAAU_RS02765	COG1175	transmembrane transport
FRAAU_RS02770	COG0395	ABC-type sugar transport system, permease component
FRAAU_RS02780	COG0246	Mannitol dehydrogenase
FRAAU_RS02785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRAAU_RS02790	COG0583	DNA-binding transcription factor activity
FRAAU_RS02795	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS02805	COG1505	serine-type exopeptidase activity
FRAAU_RS02810	COG1611	Belongs to the LOG family
FRAAU_RS02820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FRAAU_RS02825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRAAU_RS02830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRAAU_RS02835	COG1077	Cell shape determining protein MreB Mrl
FRAAU_RS02840	COG1792	Involved in formation and maintenance of cell shape
FRAAU_RS02850	COG0768	penicillin binding
FRAAU_RS02855	COG0772	Belongs to the SEDS family
FRAAU_RS02860	COG2951	lytic endotransglycosylase activity
FRAAU_RS02870	COG1686	Belongs to the peptidase S11 family
FRAAU_RS02875	COG2921	Belongs to the UPF0250 family
FRAAU_RS02885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRAAU_RS02895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRAAU_RS02940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRAAU_RS02945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRAAU_RS02955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FRAAU_RS02960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRAAU_RS02970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRAAU_RS02975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRAAU_RS02980	COG0193	aminoacyl-tRNA hydrolase activity
FRAAU_RS02985	COG0012	GTP binding
FRAAU_RS03005	COG0732	type I restriction modification DNA specificity domain
FRAAU_RS03090	COG0561	phosphatase activity
FRAAU_RS03125	COG5383	Protein conserved in bacteria
FRAAU_RS03150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRAAU_RS03160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRAAU_RS03165	COG0250	Participates in transcription elongation, termination and antitermination
FRAAU_RS03170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRAAU_RS03180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRAAU_RS03185	COG0222	ribosome binding
FRAAU_RS03195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRAAU_RS03200	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRAAU_RS03215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRAAU_RS03235	COG4774	siderophore transport
FRAAU_RS03240	COG0051	transcription antitermination factor activity, RNA binding
FRAAU_RS03245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRAAU_RS03250	COG0088	Forms part of the polypeptide exit tunnel
FRAAU_RS03255	COG0089	rRNA binding
FRAAU_RS03260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRAAU_RS03265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRAAU_RS03270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRAAU_RS03275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRAAU_RS03280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRAAU_RS03285	COG0255	Belongs to the universal ribosomal protein uL29 family
FRAAU_RS03290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRAAU_RS03300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRAAU_RS03305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRAAU_RS03310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRAAU_RS03325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRAAU_RS03330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRAAU_RS03335	COG1841	ribosomal large subunit assembly
FRAAU_RS03340	COG0200	Binds to the 23S rRNA
FRAAU_RS03345	COG0201	protein transport
FRAAU_RS03355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRAAU_RS03365	COG0202	RNA polymerase activity
FRAAU_RS03380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FRAAU_RS03400	COG0668	transmembrane transport
FRAAU_RS03415	COG0312	modulator of DNA gyrase
FRAAU_RS03420	COG2234	aminopeptidase activity
FRAAU_RS03425	COG0577	efflux transmembrane transporter activity
FRAAU_RS03440	COG3028	Belongs to the UPF0307 family
FRAAU_RS03450	COG0312	modulator of DNA gyrase
FRAAU_RS03460	COG3537	Alpha-1,2-mannosidase
FRAAU_RS03480	COG2199	diguanylate cyclase activity
FRAAU_RS03480	COG2202	Pas domain
FRAAU_RS03480	COG2200	EAL domain
FRAAU_RS03485	COG0825	malonyl-CoA metabolic process
FRAAU_RS03510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRAAU_RS03515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRAAU_RS03520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRAAU_RS03530	COG0750	zinc metalloprotease
FRAAU_RS03535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRAAU_RS03545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRAAU_RS03550	COG0233	cytoplasmic translational termination
FRAAU_RS03565	COG0052	Belongs to the universal ribosomal protein uS2 family
FRAAU_RS03570	COG0024	Methionine aminopeptidase
FRAAU_RS03575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FRAAU_RS03585	COG2171	N-acyltransferase activity
FRAAU_RS03590	COG1393	Belongs to the ArsC family
FRAAU_RS03600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRAAU_RS03625	COG3038	cytochrome b561
FRAAU_RS03655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRAAU_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS03665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRAAU_RS03675	COG1546	Belongs to the CinA family
FRAAU_RS03680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRAAU_RS03685	COG2137	regulation of response to DNA damage stimulus
FRAAU_RS03690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRAAU_RS03695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FRAAU_RS03705	COG2755	lipolytic protein G-D-S-L family
FRAAU_RS03705	COG0657	acetylesterase activity
FRAAU_RS03725	COG1657	PFAM Prenyltransferase squalene oxidase
FRAAU_RS03745	COG1956	GAF domain-containing protein
FRAAU_RS03760	COG0339	signal peptide processing
FRAAU_RS03795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRAAU_RS03805	COG0513	Belongs to the DEAD box helicase family
FRAAU_RS03810	COG2884	Cell division ATP-binding protein ftsE
FRAAU_RS03815	COG2177	Part of the ABC transporter FtsEX involved in
FRAAU_RS03820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FRAAU_RS03840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRAAU_RS03850	COG1538	Outer membrane efflux protein
FRAAU_RS03860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRAAU_RS03865	COG0534	Mate efflux family protein
FRAAU_RS03885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRAAU_RS03895	COG1960	acyl-CoA dehydrogenase activity
FRAAU_RS03925	COG0531	amino acid
FRAAU_RS03945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FRAAU_RS03950	COG2894	cell division
FRAAU_RS03965	COG4585	Histidine kinase
FRAAU_RS03970	COG2197	response regulator
FRAAU_RS03980	COG1129	ABC transporter
FRAAU_RS03980	COG0842	Transport permease protein
FRAAU_RS04005	COG1999	signal sequence binding
FRAAU_RS04010	COG2363	Small membrane protein
FRAAU_RS04030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FRAAU_RS04040	COG1946	Acyl-CoA thioesterase
FRAAU_RS04055	COG0116	Belongs to the methyltransferase superfamily
FRAAU_RS04055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FRAAU_RS04065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRAAU_RS04070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRAAU_RS04075	COG1643	Atp-dependent helicase
FRAAU_RS04080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRAAU_RS04095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRAAU_RS04110	COG3706	GGDEF domain
FRAAU_RS04115	COG1199	ATP-dependent helicase activity
FRAAU_RS04130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FRAAU_RS04140	COG2186	Transcriptional regulator
FRAAU_RS04170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRAAU_RS04175	COG2267	carboxylic ester hydrolase activity
FRAAU_RS04180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRAAU_RS04195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRAAU_RS04200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FRAAU_RS04215	COG0492	ferredoxin-NADP+ reductase activity
FRAAU_RS04220	COG1674	ftsk spoiiie
FRAAU_RS04225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRAAU_RS04245	COG1674	ftsk spoiiie
FRAAU_RS04260	COG0420	3'-5' exonuclease activity
FRAAU_RS04265	COG0419	ATPase involved in DNA repair
FRAAU_RS04285	COG2999	glutathione oxidoreductase activity
FRAAU_RS04305	COG0840	transmembrane signaling receptor activity
FRAAU_RS04310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRAAU_RS04315	COG2116	formate transmembrane transporter activity
FRAAU_RS04325	COG1187	pseudouridine synthase activity
FRAAU_RS04335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRAAU_RS04335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRAAU_RS04340	COG0802	atpase or kinase
FRAAU_RS04355	COG1530	ribonuclease E activity
FRAAU_RS04360	COG0564	pseudouridine synthase activity
FRAAU_RS04370	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRAAU_RS04375	COG0316	Belongs to the HesB IscA family
FRAAU_RS04375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FRAAU_RS04395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRAAU_RS04400	COG2957	Belongs to the agmatine deiminase family
FRAAU_RS04410	COG0488	(ABC) transporter
FRAAU_RS04420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRAAU_RS04435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRAAU_RS04450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FRAAU_RS04460	COG2982	Protein involved in outer membrane biogenesis
FRAAU_RS04490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRAAU_RS04500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRAAU_RS04505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRAAU_RS04520	COG0101	tRNA pseudouridine synthase activity
FRAAU_RS04525	COG0135	phosphoribosylanthranilate isomerase activity
FRAAU_RS04540	COG0159	tryptophan synthase activity
FRAAU_RS04545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRAAU_RS04550	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRAAU_RS04580	COG0735	belongs to the Fur family
FRAAU_RS04585	COG1230	cation diffusion facilitator family transporter
FRAAU_RS04595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRAAU_RS04600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRAAU_RS04610	COG0628	permease
FRAAU_RS04620	COG1862	Preprotein translocase
FRAAU_RS04625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRAAU_RS04630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRAAU_RS04665	COG0583	DNA-binding transcription factor activity
FRAAU_RS04735	COG0629	single-stranded DNA binding
FRAAU_RS04855	COG3657	addiction module killer protein
FRAAU_RS04885	COG4220	transposase activity
FRAAU_RS04905	COG0616	signal peptide processing
FRAAU_RS04905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRAAU_RS05035	COG2200	EAL domain
FRAAU_RS05045	COG2200	EAL domain
FRAAU_RS05070	COG2188	Transcriptional regulator
FRAAU_RS05095	COG0494	nUDIX hydrolase
FRAAU_RS05115	COG2188	Transcriptional regulator
FRAAU_RS05150	COG1309	transcriptional regulator
FRAAU_RS05160	COG2084	Dehydrogenase
FRAAU_RS05175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRAAU_RS05190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRAAU_RS05210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRAAU_RS05230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRAAU_RS05240	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FRAAU_RS05245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRAAU_RS05250	COG0481	GTPase activity
FRAAU_RS05275	COG1381	Involved in DNA repair and RecF pathway recombination
FRAAU_RS05290	COG2818	Glycosylase
FRAAU_RS05295	COG2169	Transcriptional regulator
FRAAU_RS05295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRAAU_RS05335	COG1131	(ABC) transporter
FRAAU_RS05370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRAAU_RS05375	COG0167	dihydroorotate dehydrogenase activity
FRAAU_RS05390	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS05395	COG0779	Required for maturation of 30S ribosomal subunits
FRAAU_RS05400	COG2251	uridine kinase activity
FRAAU_RS05400	COG0195	Participates in both transcription termination and antitermination
FRAAU_RS05405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRAAU_RS05415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRAAU_RS05420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRAAU_RS05425	COG1185	polyribonucleotide nucleotidyltransferase activity
FRAAU_RS05445	COG3243	poly(R)-hydroxyalkanoic acid synthase
FRAAU_RS05450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FRAAU_RS05470	COG0477	Major facilitator Superfamily
FRAAU_RS05485	COG1733	regulation of RNA biosynthetic process
FRAAU_RS05490	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FRAAU_RS05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRAAU_RS05520	COG2081	HI0933 family
FRAAU_RS05525	COG2084	Dehydrogenase
FRAAU_RS05530	COG0384	phenazine biosynthesis protein PhzF
FRAAU_RS05565	COG2011	ABC-type metal ion transport system permease component
FRAAU_RS05575	COG0386	Belongs to the glutathione peroxidase family
FRAAU_RS05585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRAAU_RS05590	COG0626	cystathionine gamma-synthase activity
FRAAU_RS05595	COG0460	homoserine dehydrogenase
FRAAU_RS05595	COG0527	aspartate kinase activity
FRAAU_RS05600	COG0531	amino acid
FRAAU_RS05635	COG1760	l-serine dehydratase
FRAAU_RS05665	COG3483	tryptophan 2,3-dioxygenase activity
FRAAU_RS05670	COG0514	ATP-dependent DNA helicase (RecQ)
FRAAU_RS05675	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRAAU_RS05685	COG0583	DNA-binding transcription factor activity
FRAAU_RS05700	COG1217	gtp-binding protein TYPA
FRAAU_RS05710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRAAU_RS05730	COG0039	L-malate dehydrogenase activity
FRAAU_RS05760	COG0861	Integral membrane protein TerC family
FRAAU_RS05765	COG1187	pseudouridine synthase activity
FRAAU_RS05780	COG1063	alcohol dehydrogenase
FRAAU_RS05785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRAAU_RS05790	COG1923	regulation of RNA biosynthetic process
FRAAU_RS05795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRAAU_RS05800	COG0494	nUDIX hydrolase
FRAAU_RS05820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRAAU_RS05830	COG4221	oxidoreductase activity
FRAAU_RS05840	COG0513	Belongs to the DEAD box helicase family
FRAAU_RS05845	COG2814	Major facilitator Superfamily
FRAAU_RS05855	COG0791	NLP P60 protein
FRAAU_RS05870	COG0482	sulfurtransferase activity
FRAAU_RS05880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRAAU_RS05885	COG0542	response to heat
FRAAU_RS05905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FRAAU_RS05910	COG0077	Prephenate dehydratase
FRAAU_RS05910	COG1605	Chorismate mutase
FRAAU_RS05915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRAAU_RS05920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FRAAU_RS05935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRAAU_RS06030	COG1064	alcohol dehydrogenase
FRAAU_RS06100	COG1733	regulation of RNA biosynthetic process
FRAAU_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS06160	COG2124	cytochrome p450
FRAAU_RS06175	COG5492	domain, Protein
FRAAU_RS06175	COG3583	domain protein
FRAAU_RS06175	COG1621	beta-fructofuranosidase activity
FRAAU_RS06190	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS06215	COG1214	PFAM Peptidase M22, glycoprotease
FRAAU_RS06225	COG0642	Histidine kinase
FRAAU_RS06235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRAAU_RS06240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRAAU_RS06250	COG1660	Displays ATPase and GTPase activities
FRAAU_RS06255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FRAAU_RS06270	COG1137	ATPase activity
FRAAU_RS06285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FRAAU_RS06300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRAAU_RS06310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRAAU_RS06315	COG1074	ATP-dependent DNA helicase activity
FRAAU_RS06320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FRAAU_RS06325	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FRAAU_RS06410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRAAU_RS06425	COG0778	Nitroreductase
FRAAU_RS06430	COG1797	cobyrinic acid a,c-diamide synthase activity
FRAAU_RS06445	COG0300	oxidoreductase activity
FRAAU_RS06450	COG0697	spore germination
FRAAU_RS06455	COG0281	malic enzyme
FRAAU_RS06455	COG0280	phosphate acetyltransferase
FRAAU_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS06605	COG3851	Histidine kinase
FRAAU_RS06620	COG1420	regulation of RNA biosynthetic process
FRAAU_RS06625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRAAU_RS06630	COG0443	Heat shock 70 kDa protein
FRAAU_RS06640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRAAU_RS06655	COG0505	Belongs to the CarA family
FRAAU_RS06660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRAAU_RS06665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRAAU_RS06675	COG3539	Fimbrial protein
FRAAU_RS06680	COG3121	Chaperone
FRAAU_RS06700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRAAU_RS06705	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRAAU_RS06705	COG1902	pentaerythritol trinitrate reductase activity
FRAAU_RS06710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FRAAU_RS06715	COG0539	negative regulation of cytoplasmic translation
FRAAU_RS06720	COG0776	regulation of translation
FRAAU_RS06755	COG3938	Belongs to the proline racemase family
FRAAU_RS06760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRAAU_RS06790	COG3345	alpha-galactosidase
FRAAU_RS06795	COG0531	amino acid
FRAAU_RS06820	COG0859	PFAM glycosyl transferase family 9
FRAAU_RS06825	COG3642	lipopolysaccharide core region biosynthetic process
FRAAU_RS06840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRAAU_RS06845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRAAU_RS06855	COG0537	adenosine 5'-monophosphoramidase activity
FRAAU_RS06875	COG0714	Associated with various cellular activities
FRAAU_RS06885	COG1399	metal-binding, possibly nucleic acid-binding protein
FRAAU_RS06890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRAAU_RS06895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRAAU_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS06915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRAAU_RS06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRAAU_RS06925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRAAU_RS06930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRAAU_RS06935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRAAU_RS06960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRAAU_RS06970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRAAU_RS06980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRAAU_RS06985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRAAU_RS06990	COG1034	ATP synthesis coupled electron transport
FRAAU_RS06995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRAAU_RS07005	COG0839	Belongs to the complex I subunit 6 family
FRAAU_RS07010	COG0713	ATP synthesis coupled electron transport
FRAAU_RS07025	COG1007	ATP synthesis coupled electron transport
FRAAU_RS07050	COG2175	clavaminate synthase activity
FRAAU_RS07055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRAAU_RS07075	COG2910	NAD(P)H-binding
FRAAU_RS07080	COG1733	regulation of RNA biosynthetic process
FRAAU_RS07110	COG2814	Major facilitator Superfamily
FRAAU_RS07120	COG0667	Aldo Keto reductase
FRAAU_RS07355	COG5410	chromosome segregation
FRAAU_RS07495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FRAAU_RS07555	COG0633	Ferredoxin
FRAAU_RS07555	COG3217	Mosc domain protein beta barrel domain protein
FRAAU_RS07560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRAAU_RS07565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FRAAU_RS07580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRAAU_RS07585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FRAAU_RS07590	COG1704	LemA family
FRAAU_RS07605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRAAU_RS07635	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FRAAU_RS07655	COG0642	Histidine kinase
FRAAU_RS07660	COG0745	RESPONSE REGULATOR receiver
FRAAU_RS07675	COG0412	Dienelactone hydrolase
FRAAU_RS07680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRAAU_RS07695	COG3118	belongs to the thioredoxin family
FRAAU_RS07700	COG2995	paraquat-inducible protein a
FRAAU_RS07705	COG2995	paraquat-inducible protein a
FRAAU_RS07710	COG3008	intermembrane lipid transfer
FRAAU_RS07720	COG0495	leucyl-tRNA aminoacylation
FRAAU_RS07735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRAAU_RS07740	COG1271	oxidase subunit
FRAAU_RS07745	COG1294	oxidase, subunit
FRAAU_RS07755	COG4988	ABC transporter
FRAAU_RS07760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FRAAU_RS07770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FRAAU_RS07795	COG1253	flavin adenine dinucleotide binding
FRAAU_RS07805	COG0438	transferase activity, transferring glycosyl groups
FRAAU_RS07830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRAAU_RS07835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRAAU_RS07845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRAAU_RS07845	COG0519	Catalyzes the synthesis of GMP from XMP
FRAAU_RS07885	COG2826	transposase and inactivated derivatives, IS30 family
FRAAU_RS07920	COG0300	oxidoreductase activity
FRAAU_RS07940	COG0210	DNA helicase
FRAAU_RS07985	COG0697	spore germination
FRAAU_RS07990	COG0531	amino acid
FRAAU_RS08005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRAAU_RS08010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRAAU_RS08025	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS08045	COG2271	Major facilitator Superfamily
FRAAU_RS08065	COG0583	DNA-binding transcription factor activity
FRAAU_RS08095	COG0084	hydrolase, TatD family'
FRAAU_RS08115	COG2009	succinate dehydrogenase
FRAAU_RS08120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRAAU_RS08130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRAAU_RS08145	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRAAU_RS08155	COG2333	competence protein COMEC
FRAAU_RS08155	COG0658	competence protein
FRAAU_RS08160	COG0811	peptide transport
FRAAU_RS08165	COG0848	biopolymer transport protein
FRAAU_RS08175	COG1663	tetraacyldisaccharide 4'-kinase activity
FRAAU_RS08190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRAAU_RS08225	COG0667	Aldo Keto reductase
FRAAU_RS08240	COG1063	alcohol dehydrogenase
FRAAU_RS08245	COG0604	alcohol dehydrogenase
FRAAU_RS08265	COG0567	Dehydrogenase, E1 component
FRAAU_RS08270	COG2850	peptidyl-arginine hydroxylation
FRAAU_RS08295	COG0402	S-adenosylhomocysteine deaminase activity
FRAAU_RS08325	COG2954	triphosphatase activity
FRAAU_RS08330	COG1472	Belongs to the glycosyl hydrolase 3 family
FRAAU_RS08340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FRAAU_RS08345	COG1278	Cold shock
FRAAU_RS08355	COG1132	(ABC) transporter
FRAAU_RS08370	COG2132	Multicopper oxidase
FRAAU_RS08380	COG0789	Transcriptional regulator
FRAAU_RS08385	COG2217	Heavy metal translocating P-type atpase
FRAAU_RS08395	COG0367	asparagine synthase
FRAAU_RS08400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRAAU_RS08405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FRAAU_RS08440	COG2350	Protein conserved in bacteria
FRAAU_RS08455	COG3115	cell septum assembly
FRAAU_RS08470	COG1570	exodeoxyribonuclease VII activity
FRAAU_RS08475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRAAU_RS08480	COG0477	Major facilitator Superfamily
FRAAU_RS08485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRAAU_RS08490	COG1858	cytochrome C peroxidase
FRAAU_RS08500	COG3971	2-oxopent-4-enoate hydratase activity
FRAAU_RS08510	COG3384	dioxygenase
FRAAU_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS08550	COG3706	GGDEF domain
FRAAU_RS08565	COG0124	histidyl-tRNA synthetase
FRAAU_RS08580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRAAU_RS08585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRAAU_RS08590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRAAU_RS08595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FRAAU_RS08595	COG0131	Imidazoleglycerol-phosphate dehydratase
FRAAU_RS08600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRAAU_RS08605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FRAAU_RS08615	COG0140	phosphoribosyl-ATP diphosphatase activity
FRAAU_RS08615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRAAU_RS08630	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FRAAU_RS08650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRAAU_RS08655	COG1509	lysine 2,3-aminomutase activity
FRAAU_RS08665	COG0402	S-adenosylhomocysteine deaminase activity
FRAAU_RS08675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRAAU_RS08690	COG1469	GTP cyclohydrolase I activity
FRAAU_RS08720	COG4771	TonB-dependent receptor
FRAAU_RS08730	COG0730	response to heat
FRAAU_RS08735	COG2824	Alkylphosphonate utilization operon protein PhnA
FRAAU_RS08740	COG3180	Ammonia monooxygenase
FRAAU_RS08745	COG1335	isochorismatase
FRAAU_RS08785	COG0837	glucose binding
FRAAU_RS08790	COG1446	asparaginase
FRAAU_RS08795	COG3537	Alpha-1,2-mannosidase
FRAAU_RS08810	COG0477	Major facilitator Superfamily
FRAAU_RS08815	COG1414	Transcriptional regulator
FRAAU_RS08905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRAAU_RS08915	COG1388	LysM domain
FRAAU_RS08915	COG0741	lytic transglycosylase activity
FRAAU_RS08920	COG0688	phosphatidylethanolamine metabolic process
FRAAU_RS08925	COG2890	protein-(glutamine-N5) methyltransferase activity
FRAAU_RS08930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRAAU_RS08935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRAAU_RS08940	COG0746	molybdenum cofactor guanylyltransferase activity
FRAAU_RS08940	COG0315	cyclic pyranopterin monophosphate synthase activity
FRAAU_RS08955	COG0243	molybdopterin cofactor binding
FRAAU_RS08965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FRAAU_RS08970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRAAU_RS08975	COG1120	ATPase activity
FRAAU_RS08985	COG2267	carboxylic ester hydrolase activity
FRAAU_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS08995	COG0028	Belongs to the TPP enzyme family
FRAAU_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS09015	COG0477	Major facilitator Superfamily
FRAAU_RS09025	COG0346	lactoylglutathione lyase activity
FRAAU_RS09040	COG0656	L-ascorbic acid biosynthetic process
FRAAU_RS09070	COG2963	transposase activity
FRAAU_RS09095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRAAU_RS09100	COG1309	transcriptional regulator
FRAAU_RS09105	COG1979	alcohol dehydrogenase
FRAAU_RS09110	COG2130	NADP-dependent
FRAAU_RS09120	COG0583	DNA-binding transcription factor activity
FRAAU_RS09125	COG2814	Major facilitator Superfamily
FRAAU_RS09145	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRAAU_RS09150	COG4681	YaeQ
FRAAU_RS09155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRAAU_RS09170	COG2010	Cytochrome c
FRAAU_RS09175	COG1609	Transcriptional regulator
FRAAU_RS09240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRAAU_RS09245	COG1534	Rna-binding protein
FRAAU_RS09260	COG1238	metal cluster binding
FRAAU_RS09265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRAAU_RS09285	COG2239	Acts as a magnesium transporter
FRAAU_RS09290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRAAU_RS09295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRAAU_RS09300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FRAAU_RS09315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FRAAU_RS09325	COG0006	proline dipeptidase activity
FRAAU_RS09335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRAAU_RS09340	COG2902	Dehydrogenase
FRAAU_RS09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRAAU_RS09350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRAAU_RS09370	COG3023	N-Acetylmuramoyl-L-alanine amidase
FRAAU_RS09395	COG4948	Mandelate Racemase Muconate Lactonizing
FRAAU_RS09400	COG2271	Major facilitator Superfamily
FRAAU_RS09415	COG0305	Participates in initiation and elongation during chromosome replication
FRAAU_RS09425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRAAU_RS09430	COG0360	Binds together with S18 to 16S ribosomal RNA
FRAAU_RS09435	COG0316	Belongs to the HesB IscA family
FRAAU_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS09470	COG0251	oxidation-reduction process
FRAAU_RS09480	COG1289	transmembrane transporter activity
FRAAU_RS09490	COG0314	molybdopterin synthase activity
FRAAU_RS09495	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRAAU_RS09495	COG0315	cyclic pyranopterin monophosphate synthase activity
FRAAU_RS09500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FRAAU_RS09510	COG0303	'Molybdopterin
FRAAU_RS09515	COG2010	Cytochrome c
FRAAU_RS09515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRAAU_RS09530	COG4771	TonB-dependent receptor
FRAAU_RS09550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FRAAU_RS09555	COG0281	malic enzyme
FRAAU_RS09570	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FRAAU_RS09570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRAAU_RS09605	COG0523	cobalamin synthesis protein
FRAAU_RS09625	COG0583	DNA-binding transcription factor activity
FRAAU_RS09630	COG2814	Major facilitator Superfamily
FRAAU_RS09635	COG0656	L-ascorbic acid biosynthetic process
FRAAU_RS09640	COG1902	pentaerythritol trinitrate reductase activity
FRAAU_RS09650	COG0583	DNA-binding transcription factor activity
FRAAU_RS09660	COG2207	Transcriptional regulator
FRAAU_RS09665	COG0277	FAD linked oxidase domain protein
FRAAU_RS09830	COG0582	viral genome integration into host DNA
FRAAU_RS09870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRAAU_RS09885	COG2925	Exonuclease
FRAAU_RS09895	COG0477	Major facilitator Superfamily
FRAAU_RS09910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FRAAU_RS09935	COG0531	amino acid
FRAAU_RS09940	COG0531	amino acid
FRAAU_RS09945	COG1160	GTP binding
FRAAU_RS09950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRAAU_RS09975	COG0105	UTP biosynthetic process
FRAAU_RS09980	COG1309	transcriptional regulator
FRAAU_RS09985	COG1024	Enoyl-CoA hydratase
FRAAU_RS09985	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRAAU_RS09990	COG0183	Belongs to the thiolase family
FRAAU_RS09995	COG0204	Acyl-transferase
FRAAU_RS10000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRAAU_RS10005	COG0719	Fe-S assembly protein
FRAAU_RS10010	COG0396	ATPase activity
FRAAU_RS10015	COG0719	Fe-S assembly protein
FRAAU_RS10020	COG1959	2 iron, 2 sulfur cluster binding
FRAAU_RS10035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRAAU_RS10040	COG3178	'Phosphotransferase
FRAAU_RS10045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRAAU_RS10050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRAAU_RS10065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FRAAU_RS10095	COG0840	transmembrane signaling receptor activity
FRAAU_RS10105	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FRAAU_RS10110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FRAAU_RS10115	COG0840	transmembrane signaling receptor activity
FRAAU_RS10120	COG0835	chemotaxis
FRAAU_RS10125	COG0643	Histidine kinase
FRAAU_RS10125	COG2198	Histidine kinase
FRAAU_RS10130	COG2201	protein-glutamate methylesterase activity
FRAAU_RS10160	COG0840	transmembrane signaling receptor activity
FRAAU_RS10165	COG0835	chemotaxis
FRAAU_RS10165	COG0784	Response regulator, receiver
FRAAU_RS10170	COG1815	bacterial-type flagellum-dependent cell motility
FRAAU_RS10180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FRAAU_RS10185	COG1749	Flagellar hook protein flgE
FRAAU_RS10200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FRAAU_RS10210	COG1705	Flagellar rod assembly protein muramidase FlgJ
FRAAU_RS10210	COG3951	Flagellar rod assembly protein muramidase FlgJ
FRAAU_RS10230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FRAAU_RS10245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FRAAU_RS10250	COG1516	flagellar protein fliS
FRAAU_RS10280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FRAAU_RS10345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FRAAU_RS10350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FRAAU_RS10380	COG2198	Histidine kinase
FRAAU_RS10380	COG0643	Histidine kinase
FRAAU_RS10380	COG0784	Response regulator, receiver
FRAAU_RS10385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FRAAU_RS10390	COG1360	Flagellar Motor Protein
FRAAU_RS10410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FRAAU_RS10415	COG0165	Argininosuccinate lyase
FRAAU_RS10425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FRAAU_RS10435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRAAU_RS10440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRAAU_RS10450	COG0137	argininosuccinate synthase activity
FRAAU_RS10460	COG2808	Putative FMN-binding domain
FRAAU_RS10465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FRAAU_RS10515	COG0640	Transcriptional regulator
FRAAU_RS10520	COG1902	pentaerythritol trinitrate reductase activity
FRAAU_RS10540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FRAAU_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRAAU_RS10550	COG4558	Periplasmic binding protein
FRAAU_RS10555	COG3720	iron ion transport
FRAAU_RS10560	COG4206	TonB-dependent receptor
FRAAU_RS10565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRAAU_RS10570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FRAAU_RS10575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FRAAU_RS10585	COG0477	Major facilitator Superfamily
FRAAU_RS10595	COG0583	DNA-binding transcription factor activity
FRAAU_RS10600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRAAU_RS10620	COG3787	Belongs to the UPF0306 family
FRAAU_RS10640	COG0335	large ribosomal subunit rRNA binding
FRAAU_RS10645	COG0336	Belongs to the RNA methyltransferase TrmD family
FRAAU_RS10650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRAAU_RS10655	COG0228	four-way junction DNA binding
FRAAU_RS10660	COG4521	taurine ABC transporter
FRAAU_RS10670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRAAU_RS10675	COG2175	clavaminate synthase activity
FRAAU_RS10680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRAAU_RS10725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRAAU_RS10735	COG2833	Protein of unknown function (DUF455)
FRAAU_RS10745	COG1286	toxin biosynthetic process
FRAAU_RS10755	COG0285	dihydrofolate synthase activity
FRAAU_RS10765	COG0134	indole-3-glycerol-phosphate synthase activity
FRAAU_RS10770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRAAU_RS10795	COG4774	siderophore transport
FRAAU_RS10805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRAAU_RS10860	COG0489	protein tyrosine kinase activity
FRAAU_RS10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRAAU_RS10870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRAAU_RS10880	COG2878	Part of a membrane complex involved in electron transport
FRAAU_RS10885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRAAU_RS10905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRAAU_RS10915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRAAU_RS10930	COG0776	regulation of translation
FRAAU_RS10940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRAAU_RS10945	COG0740	serine-type endopeptidase activity
FRAAU_RS10960	COG1132	(ABC) transporter
FRAAU_RS10965	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FRAAU_RS10965	COG3264	Mechanosensitive ion channel
FRAAU_RS10970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FRAAU_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS11015	COG2207	Transcriptional regulator
FRAAU_RS11020	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS11030	COG0583	DNA-binding transcription factor activity
FRAAU_RS11035	COG2267	carboxylic ester hydrolase activity
FRAAU_RS11045	COG2095	MarC family integral membrane protein
FRAAU_RS11050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRAAU_RS11055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRAAU_RS11070	COG2835	tetraacyldisaccharide 4'-kinase activity
FRAAU_RS11085	COG2969	positive regulation of protein catabolic process
FRAAU_RS11095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRAAU_RS11100	COG0723	plastoquinol--plastocyanin reductase activity
FRAAU_RS11105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRAAU_RS11110	COG0741	lytic transglycosylase activity
FRAAU_RS11115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRAAU_RS11120	COG1702	phosphate starvation-inducible protein PhoH
FRAAU_RS11125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRAAU_RS11140	COG0598	Magnesium transport protein CorA
FRAAU_RS11145	COG1506	peptidase
FRAAU_RS11145	COG0823	Involved in the tonB-independent uptake of proteins
FRAAU_RS11165	COG0406	alpha-ribazole phosphatase activity
FRAAU_RS11190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRAAU_RS11210	COG2207	Transcriptional regulator
FRAAU_RS11215	COG4221	oxidoreductase activity
FRAAU_RS11235	COG1733	regulation of RNA biosynthetic process
FRAAU_RS11240	COG0702	epimerase
FRAAU_RS11260	COG3328	transposase activity
FRAAU_RS11290	COG2010	Cytochrome c
FRAAU_RS11330	COG1595	DNA-templated transcription, initiation
FRAAU_RS11370	COG4716	Myosin-crossreactive antigen
FRAAU_RS11375	COG1742	UPF0060 membrane protein
FRAAU_RS11385	COG3590	peptidase
FRAAU_RS11400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRAAU_RS11405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRAAU_RS11410	COG0642	Histidine kinase
FRAAU_RS11415	COG0745	RESPONSE REGULATOR receiver
FRAAU_RS11425	COG4181	ATPase activity
FRAAU_RS11435	COG0443	Heat shock 70 kDa protein
FRAAU_RS11440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FRAAU_RS11455	COG3956	TIGRFAM MazG family protein
FRAAU_RS11465	COG0494	nUDIX hydrolase
FRAAU_RS11470	COG0483	inositol monophosphate 1-phosphatase activity
FRAAU_RS11485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRAAU_RS11490	COG0189	ligase activity
FRAAU_RS11505	COG1678	Uncharacterized ACR, COG1678
FRAAU_RS11510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRAAU_RS11515	COG0540	Belongs to the ATCase OTCase family
FRAAU_RS11525	COG4771	TonB-dependent receptor
FRAAU_RS11530	COG4771	TonB-dependent receptor
FRAAU_RS11545	COG1253	flavin adenine dinucleotide binding
FRAAU_RS11555	COG0306	phosphate transporter
FRAAU_RS11585	COG0704	Plays a role in the regulation of phosphate uptake
FRAAU_RS11600	COG0573	inorganic phosphate transmembrane transporter activity
FRAAU_RS11605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRAAU_RS11620	COG0343	queuine tRNA-ribosyltransferase activity
FRAAU_RS11625	COG0457	Tetratricopeptide repeat
FRAAU_RS11630	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FRAAU_RS11635	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS11640	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS11655	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FRAAU_RS11660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FRAAU_RS11675	COG2194	sulfuric ester hydrolase activity
FRAAU_RS11690	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS11695	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS11705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FRAAU_RS11710	COG2197	response regulator
FRAAU_RS11715	COG4585	Histidine kinase
FRAAU_RS11735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FRAAU_RS11745	COG0277	FAD linked oxidase domain protein
FRAAU_RS11750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRAAU_RS11760	COG1049	propionate catabolic process, 2-methylcitrate cycle
FRAAU_RS11775	COG4773	Receptor
FRAAU_RS11780	COG0583	DNA-binding transcription factor activity
FRAAU_RS11795	COG4774	siderophore transport
FRAAU_RS11800	COG2814	Major facilitator Superfamily
FRAAU_RS11815	COG3706	GGDEF domain
FRAAU_RS11820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRAAU_RS11830	COG1573	uracil-dna glycosylase
FRAAU_RS11840	COG0010	Belongs to the arginase family
FRAAU_RS11850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRAAU_RS11875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRAAU_RS11875	COG0047	phosphoribosylformylglycinamidine synthase activity
FRAAU_RS11880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRAAU_RS11895	COG4974	Belongs to the 'phage' integrase family
FRAAU_RS11910	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FRAAU_RS11920	COG0795	lipopolysaccharide-transporting ATPase activity
FRAAU_RS11930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRAAU_RS11940	COG3850	Histidine kinase
FRAAU_RS11940	COG3437	response regulator, receiver
FRAAU_RS11940	COG4999	Histidine kinase
FRAAU_RS11940	COG2205	protein histidine kinase activity
FRAAU_RS11950	COG0534	Mate efflux family protein
FRAAU_RS11965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRAAU_RS11970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRAAU_RS11975	COG0784	Response regulator, receiver
FRAAU_RS11975	COG2198	Histidine kinase
FRAAU_RS11975	COG2205	protein histidine kinase activity
FRAAU_RS11980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FRAAU_RS12020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRAAU_RS12020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRAAU_RS12025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRAAU_RS12040	COG0318	PFAM AMP-dependent synthetase and ligase
FRAAU_RS12045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRAAU_RS12050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRAAU_RS12055	COG1187	pseudouridine synthase activity
FRAAU_RS12060	COG1393	Belongs to the ArsC family
FRAAU_RS12065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRAAU_RS12070	COG0436	Aminotransferase
FRAAU_RS12075	COG0583	DNA-binding transcription factor activity
FRAAU_RS12100	COG0072	phenylalanine-tRNA ligase activity
FRAAU_RS12100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRAAU_RS12110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRAAU_RS12120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRAAU_RS12125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRAAU_RS12135	COG4221	oxidoreductase activity
FRAAU_RS12140	COG1981	membrane
FRAAU_RS12165	COG2814	Major facilitator Superfamily
FRAAU_RS12170	COG0840	transmembrane signaling receptor activity
FRAAU_RS12220	COG2826	transposase and inactivated derivatives, IS30 family
FRAAU_RS12230	COG0556	nucleotide-excision repair
FRAAU_RS12240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRAAU_RS12245	COG0456	acetyltransferase
FRAAU_RS12270	COG2890	protein-(glutamine-N5) methyltransferase activity
FRAAU_RS12275	COG0583	DNA-binding transcription factor activity
FRAAU_RS12280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRAAU_RS12290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRAAU_RS12315	COG0330	HflC and HflK could
FRAAU_RS12365	COG0328	RNA-DNA hybrid ribonuclease activity
FRAAU_RS12380	COG1388	LysM domain
FRAAU_RS12380	COG1705	Flagellar rod assembly protein muramidase FlgJ
FRAAU_RS12395	COG1733	regulation of RNA biosynthetic process
FRAAU_RS12405	COG2900	Belongs to the SlyX family
FRAAU_RS12415	COG0791	NLP P60 protein
FRAAU_RS12420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FRAAU_RS12425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRAAU_RS12430	COG1555	photosystem II stabilization
FRAAU_RS12450	COG3590	peptidase
FRAAU_RS12475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRAAU_RS12480	COG0557	exoribonuclease II activity
FRAAU_RS12515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRAAU_RS12515	COG4651	solute:proton antiporter activity
FRAAU_RS12575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRAAU_RS12595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRAAU_RS12600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRAAU_RS12605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRAAU_RS12610	COG0617	tRNA 3'-terminal CCA addition
FRAAU_RS12620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRAAU_RS12630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRAAU_RS12640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRAAU_RS12645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FRAAU_RS12655	COG0473	3-isopropylmalate dehydrogenase activity
FRAAU_RS12665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRAAU_RS12670	COG4783	chaperone-mediated protein folding
FRAAU_RS12675	COG0745	RESPONSE REGULATOR receiver
FRAAU_RS12690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRAAU_RS12695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRAAU_RS12745	COG1929	Belongs to the glycerate kinase type-1 family
FRAAU_RS12750	COG2610	gluconate transmembrane transporter activity
FRAAU_RS12755	COG3835	regulator
FRAAU_RS12760	COG0656	L-ascorbic acid biosynthetic process
FRAAU_RS12800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRAAU_RS12805	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRAAU_RS12810	COG0022	dehydrogenase e1 component
FRAAU_RS12815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRAAU_RS12835	COG4133	protoheme IX ABC transporter activity
FRAAU_RS12865	COG0583	DNA-binding transcription factor activity
FRAAU_RS12875	COG1902	pentaerythritol trinitrate reductase activity
FRAAU_RS12895	COG0582	viral genome integration into host DNA
FRAAU_RS12905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRAAU_RS12920	COG0196	riboflavin kinase activity
FRAAU_RS12930	COG0268	Binds directly to 16S ribosomal RNA
FRAAU_RS12940	COG0076	glutamate decarboxylase activity
FRAAU_RS12945	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FRAAU_RS12960	COG4774	siderophore transport
FRAAU_RS12965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRAAU_RS12975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRAAU_RS12985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRAAU_RS12990	COG0028	Belongs to the TPP enzyme family
FRAAU_RS12995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRAAU_RS13000	COG1126	abc transporter atp-binding protein
FRAAU_RS13005	COG0765	amino acid transport
FRAAU_RS13015	COG4221	oxidoreductase activity
FRAAU_RS13020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FRAAU_RS13030	COG1984	allophanate hydrolase subunit 2
FRAAU_RS13035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FRAAU_RS13045	COG0477	Major facilitator Superfamily
FRAAU_RS13050	COG0436	Aminotransferase
FRAAU_RS13065	COG3527	Alpha-acetolactate decarboxylase
FRAAU_RS13075	COG0247	lactate metabolic process
FRAAU_RS13080	COG1139	Iron-sulfur cluster binding protein
FRAAU_RS13095	COG1309	transcriptional regulator
FRAAU_RS13100	COG1960	acyl-CoA dehydrogenase activity
FRAAU_RS13105	COG2814	Major facilitator Superfamily
FRAAU_RS13130	COG1272	protein, Hemolysin III
FRAAU_RS13135	COG3781	membrane
FRAAU_RS13150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRAAU_RS13165	COG1335	isochorismatase
FRAAU_RS13170	COG0415	Belongs to the DNA photolyase family
FRAAU_RS13180	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FRAAU_RS13200	COG2205	protein histidine kinase activity
FRAAU_RS13205	COG0745	RESPONSE REGULATOR receiver
FRAAU_RS13215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRAAU_RS13230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRAAU_RS13250	COG0457	Tetratricopeptide repeat
FRAAU_RS13255	COG5212	phosphodiesterase
FRAAU_RS13260	COG0531	amino acid
FRAAU_RS13265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRAAU_RS13270	COG0246	Mannitol dehydrogenase
FRAAU_RS13280	COG2199	diguanylate cyclase activity
FRAAU_RS13280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FRAAU_RS13285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRAAU_RS13290	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRAAU_RS13295	COG0668	transmembrane transport
FRAAU_RS13340	COG0625	glutathione transferase activity
FRAAU_RS13355	COG0280	phosphate acetyltransferase
FRAAU_RS13355	COG0281	malic enzyme
FRAAU_RS13365	COG0436	Aminotransferase
FRAAU_RS13380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRAAU_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS13390	COG1121	(ABC) transporter
FRAAU_RS13395	COG0616	signal peptide processing
FRAAU_RS13410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRAAU_RS13450	COG1368	sulfuric ester hydrolase activity
FRAAU_RS13485	COG2308	Evidence 4 Homologs of previously reported genes of
FRAAU_RS13495	COG0668	transmembrane transport
FRAAU_RS13500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FRAAU_RS13505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRAAU_RS13530	COG0025	NhaP-type Na H and K H
FRAAU_RS13540	COG0109	protoheme IX farnesyltransferase activity
FRAAU_RS13570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRAAU_RS13575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRAAU_RS13620	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRAAU_RS13625	COG1970	mechanosensitive ion channel activity
FRAAU_RS13640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRAAU_RS13650	COG0527	aspartate kinase activity
FRAAU_RS13680	COG0714	Associated with various cellular activities
FRAAU_RS13690	COG1136	(ABC) transporter
FRAAU_RS13690	COG0577	efflux transmembrane transporter activity
FRAAU_RS13770	COG0372	Belongs to the citrate synthase family
FRAAU_RS13775	COG0254	rRNA binding
FRAAU_RS13795	COG1305	Transglutaminase-like
FRAAU_RS13815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRAAU_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS13835	COG0463	Glycosyl transferase, family 2
FRAAU_RS13850	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FRAAU_RS13855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRAAU_RS13860	COG0509	glycine decarboxylation via glycine cleavage system
FRAAU_RS13870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRAAU_RS13875	COG1127	ABC transporter
FRAAU_RS13935	COG2963	transposase activity
FRAAU_RS13985	COG4221	oxidoreductase activity
FRAAU_RS13990	COG1368	sulfuric ester hydrolase activity
FRAAU_RS13995	COG0604	alcohol dehydrogenase
FRAAU_RS13995	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS13995	COG3321	synthase
FRAAU_RS14000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FRAAU_RS14005	COG0156	8-amino-7-oxononanoate synthase activity
FRAAU_RS14015	COG2086	electron transfer activity
FRAAU_RS14035	COG0626	cystathionine gamma-synthase activity
FRAAU_RS14060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FRAAU_RS14060	COG0662	Cupin 2, conserved barrel domain protein
FRAAU_RS14105	COG0700	Nucleoside recognition
FRAAU_RS14110	COG0629	single-stranded DNA binding
FRAAU_RS14125	COG4953	penicillin-binding protein 1C
FRAAU_RS14135	COG3042	response to heat
FRAAU_RS14170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRAAU_RS14175	COG0602	queuosine metabolic process
FRAAU_RS14185	COG2885	chlorophyll binding
FRAAU_RS14205	COG0811	peptide transport
FRAAU_RS14210	COG0824	Thioesterase
FRAAU_RS14215	COG2255	four-way junction helicase activity
FRAAU_RS14225	COG0632	four-way junction helicase activity
FRAAU_RS14245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRAAU_RS14260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRAAU_RS14265	COG0542	response to heat
FRAAU_RS14275	COG3387	PFAM Glycoside hydrolase 15-related
FRAAU_RS14280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRAAU_RS14285	COG1496	oxidoreductase activity
FRAAU_RS14290	COG0564	pseudouridine synthase activity
FRAAU_RS14305	COG4221	oxidoreductase activity
FRAAU_RS14310	COG1309	transcriptional regulator
FRAAU_RS14325	COG0583	DNA-binding transcription factor activity
FRAAU_RS14335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRAAU_RS14345	COG4191	Histidine kinase
FRAAU_RS14370	COG1271	oxidase subunit
FRAAU_RS14375	COG1294	oxidase, subunit
FRAAU_RS14380	COG0432	Pfam Uncharacterised protein family UPF0047
FRAAU_RS14385	COG0259	pyridoxamine-phosphate oxidase activity
FRAAU_RS14390	COG0572	uridine kinase
FRAAU_RS14400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRAAU_RS14415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRAAU_RS14425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRAAU_RS14435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRAAU_RS14440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRAAU_RS14445	COG0175	sulfate reduction
FRAAU_RS14450	COG0529	Catalyzes the synthesis of activated sulfate
FRAAU_RS14450	COG2046	Belongs to the sulfate adenylyltransferase family
FRAAU_RS14460	COG1648	precorrin-2 dehydrogenase activity
FRAAU_RS14460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRAAU_RS14490	COG0459	protein refolding
FRAAU_RS14505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRAAU_RS14510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FRAAU_RS14515	COG0511	ligase activity, forming carbon-carbon bonds
FRAAU_RS14520	COG0439	Biotin carboxylase
FRAAU_RS14525	COG2264	protein methyltransferase activity
FRAAU_RS14540	COG0138	bifunctional purine biosynthesis protein purh
FRAAU_RS14550	COG2814	Major facilitator Superfamily
FRAAU_RS14575	COG0210	DNA helicase
FRAAU_RS14595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRAAU_RS14625	COG0745	RESPONSE REGULATOR receiver
FRAAU_RS14630	COG2205	protein histidine kinase activity
FRAAU_RS14645	COG0431	NADPH-dependent FMN reductase
FRAAU_RS14650	COG0436	Aminotransferase
FRAAU_RS14660	COG2814	Major facilitator Superfamily
FRAAU_RS14665	COG1072	(Pantothenic acid kinase))
FRAAU_RS14670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRAAU_RS14670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRAAU_RS14670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FRAAU_RS14675	COG1105	Belongs to the carbohydrate kinase PfkB family
FRAAU_RS14680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRAAU_RS14680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRAAU_RS14685	COG1609	Transcriptional regulator
FRAAU_RS14695	COG0302	gtp cyclohydrolase
FRAAU_RS14710	COG1196	nuclear chromosome segregation
FRAAU_RS14725	COG1199	ATP-dependent helicase activity
FRAAU_RS14730	COG0308	aminopeptidase N
FRAAU_RS14745	COG3604	Transcriptional regulator
FRAAU_RS14750	COG0814	amino acid
FRAAU_RS14765	COG3550	peptidyl-serine autophosphorylation
FRAAU_RS14775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRAAU_RS14800	COG0126	phosphoglycerate kinase activity
FRAAU_RS14805	COG0142	geranyltranstransferase activity
FRAAU_RS14810	COG2814	Major facilitator Superfamily
FRAAU_RS14815	COG4772	TonB-dependent receptor
FRAAU_RS14820	COG1324	tolerance protein
FRAAU_RS14825	COG0493	'glutamate synthase
FRAAU_RS14830	COG0067	glutamate synthase
FRAAU_RS14830	COG0070	glutamate synthase
FRAAU_RS14830	COG0069	glutamate synthase activity
FRAAU_RS14835	COG4942	peptidase
FRAAU_RS14840	COG0793	Belongs to the peptidase S41A family
FRAAU_RS14870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRAAU_RS14885	COG3121	Chaperone
FRAAU_RS14890	COG3539	Fimbrial protein
FRAAU_RS14895	COG1668	transmembrane transport
FRAAU_RS14900	COG4555	ABC transporter
FRAAU_RS14910	COG1131	(ABC) transporter
FRAAU_RS14915	COG0842	Transport permease protein
FRAAU_RS14920	COG1252	NADH dehydrogenase
FRAAU_RS14925	COG0513	Belongs to the DEAD box helicase family
FRAAU_RS14965	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
FRAAU_RS14975	COG2974	May be involved in recombination
FRAAU_RS14995	COG3195	allantoin biosynthetic process
FRAAU_RS14995	COG3648	Uricase
FRAAU_RS15015	COG2233	PERMEase
FRAAU_RS15020	COG2351	hydroxyisourate hydrolase activity
FRAAU_RS15030	COG4266	Belongs to the allantoicase family
FRAAU_RS15065	COG0583	DNA-binding transcription factor activity
FRAAU_RS15135	COG0582	viral genome integration into host DNA
FRAAU_RS15155	COG2193	ferroxidase activity
FRAAU_RS15160	COG0316	Belongs to the HesB IscA family
FRAAU_RS15165	COG2816	NAD+ diphosphatase activity
FRAAU_RS15170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FRAAU_RS15175	COG0667	Aldo Keto reductase
FRAAU_RS15180	COG0151	Belongs to the GarS family
FRAAU_RS15200	COG0009	L-threonylcarbamoyladenylate synthase
FRAAU_RS15210	COG0758	DNA mediated transformation
FRAAU_RS15225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRAAU_RS15230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRAAU_RS15245	COG1215	transferase activity, transferring glycosyl groups
FRAAU_RS15255	COG0583	DNA-binding transcription factor activity
FRAAU_RS15265	COG0339	signal peptide processing
FRAAU_RS15280	COG3265	gluconokinase activity
FRAAU_RS15285	COG0357	Ribosomal RNA small subunit methyltransferase G
FRAAU_RS15290	COG1192	Involved in chromosome partitioning
FRAAU_RS15295	COG1475	DNA binding
FRAAU_RS15300	COG0463	Glycosyl transferase, family 2
FRAAU_RS15325	COG0037	tRNA processing
FRAAU_RS15335	COG1566	PFAM secretion protein HlyD family protein
FRAAU_RS15360	COG0612	Peptidase, M16
FRAAU_RS15365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRAAU_RS15380	COG0564	pseudouridine synthase activity
FRAAU_RS15400	COG1012	belongs to the aldehyde dehydrogenase family
FRAAU_RS15430	COG0848	biopolymer transport protein
FRAAU_RS15440	COG1285	pathogenesis
FRAAU_RS15445	COG0300	oxidoreductase activity
FRAAU_RS15475	COG0583	DNA-binding transcription factor activity
FRAAU_RS15480	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS15490	COG2375	cellular response to nickel ion
FRAAU_RS15490	COG1132	(ABC) transporter
FRAAU_RS15495	COG1132	(ABC) transporter
FRAAU_RS15495	COG2375	cellular response to nickel ion
FRAAU_RS15505	COG0583	DNA-binding transcription factor activity
FRAAU_RS15555	COG0583	DNA-binding transcription factor activity
FRAAU_RS15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRAAU_RS15590	COG0837	glucose binding
FRAAU_RS15595	COG0277	FAD linked oxidase domain protein
FRAAU_RS15600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRAAU_RS15605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRAAU_RS15615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRAAU_RS15620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRAAU_RS15625	COG2223	nitrite transmembrane transporter activity
FRAAU_RS15635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRAAU_RS15645	COG0038	chloride channel
FRAAU_RS15650	COG1764	response to oxidative stress
FRAAU_RS15655	COG1846	Transcriptional regulator
FRAAU_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
FRAAU_RS15680	COG3511	phospholipase C
FRAAU_RS15690	COG0531	amino acid
FRAAU_RS15705	COG0783	Belongs to the Dps family
FRAAU_RS15710	COG0584	glycerophosphoryl diester phosphodiesterase
FRAAU_RS15715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FRAAU_RS15730	COG1538	Outer membrane efflux protein
FRAAU_RS15735	COG1566	PFAM secretion protein HlyD family protein
FRAAU_RS15740	COG2814	Major facilitator Superfamily
FRAAU_RS15745	COG5380	lipid catabolic process
FRAAU_RS15750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FRAAU_RS15760	COG0460	homoserine dehydrogenase
FRAAU_RS15760	COG0527	aspartate kinase activity
FRAAU_RS15770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRAAU_RS15780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRAAU_RS15790	COG0473	3-isopropylmalate dehydrogenase activity
FRAAU_RS15795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRAAU_RS15800	COG0028	Belongs to the TPP enzyme family
FRAAU_RS15805	COG0440	acetolactate synthase activity
FRAAU_RS15825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FRAAU_RS15850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRAAU_RS15860	COG1657	PFAM Prenyltransferase squalene oxidase
FRAAU_RS15870	COG0142	geranyltranstransferase activity
FRAAU_RS15885	COG3634	alkyl hydroperoxide reductase activity
FRAAU_RS15895	COG1869	D-ribose catabolic process
FRAAU_RS15900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRAAU_RS15945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRAAU_RS15960	COG0210	DNA helicase
FRAAU_RS15975	COG2937	Belongs to the GPAT DAPAT family
FRAAU_RS15980	COG0129	dihydroxy-acid dehydratase activity
FRAAU_RS15985	COG2226	methyltransferase
FRAAU_RS16005	COG1166	arginine decarboxylase activity
FRAAU_RS16010	COG2814	Major facilitator Superfamily
FRAAU_RS16015	COG2814	Major facilitator Superfamily
FRAAU_RS16025	COG2814	Major facilitator Superfamily
FRAAU_RS16030	COG1566	PFAM secretion protein HlyD family protein
FRAAU_RS16045	COG4946	Tricorn protease homolog
FRAAU_RS16045	COG1506	peptidase
FRAAU_RS16045	COG0823	Involved in the tonB-independent uptake of proteins
FRAAU_RS16055	COG0181	hydroxymethylbilane synthase activity
FRAAU_RS16065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRAAU_RS16090	COG3852	Histidine kinase
FRAAU_RS16095	COG0174	glutamine synthetase
FRAAU_RS16105	COG0705	Rhomboid family
FRAAU_RS16125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRAAU_RS16130	COG2003	Belongs to the UPF0758 family
FRAAU_RS16160	COG0534	Mate efflux family protein
FRAAU_RS16175	COG3416	Protein conserved in bacteria
FRAAU_RS16175	COG2943	transferase activity, transferring hexosyl groups
FRAAU_RS16190	COG3384	dioxygenase
FRAAU_RS16205	COG0631	protein serine/threonine phosphatase activity
FRAAU_RS16215	COG2815	serine threonine protein kinase
FRAAU_RS16215	COG0515	serine threonine protein kinase
FRAAU_RS16230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRAAU_RS16235	COG0706	membrane insertase activity
FRAAU_RS16265	COG4774	siderophore transport
FRAAU_RS16300	COG0406	alpha-ribazole phosphatase activity
FRAAU_RS16305	COG0583	DNA-binding transcription factor activity
FRAAU_RS16485	COG3706	GGDEF domain
FRAAU_RS16490	COG0582	viral genome integration into host DNA
FRAAU_RS16540	COG1216	Glycosyl transferase, family 2
FRAAU_RS16540	COG0438	transferase activity, transferring glycosyl groups
FRAAU_RS16555	COG2200	EAL domain
FRAAU_RS16570	COG0242	peptide deformylase activity
FRAAU_RS16580	COG0546	phosphoglycolate phosphatase activity
FRAAU_RS16615	COG3706	GGDEF domain
FRAAU_RS16630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRAAU_RS16645	COG3706	GGDEF domain
FRAAU_RS16670	COG3064	Membrane
FRAAU_RS16680	COG0477	Major facilitator Superfamily
FRAAU_RS16690	COG2207	Transcriptional regulator
FRAAU_RS16690	COG0662	Cupin 2, conserved barrel domain protein