locus-tag	class	description
LF543_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LF543_RS00010	COG0592	DNA-directed DNA polymerase activity
LF543_RS00015	COG2501	S4 domain
LF543_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LF543_RS00025	COG0187	DNA topoisomerase II activity
LF543_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
LF543_RS00045	COG0629	single-stranded DNA binding
LF543_RS00050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LF543_RS00060	COG0359	binds to the 23S rRNA
LF543_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
LF543_RS00070	COG2211	Major facilitator Superfamily
LF543_RS00080	COG0745	RESPONSE REGULATOR receiver
LF543_RS00100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LF543_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LF543_RS00110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LF543_RS00120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LF543_RS00130	COG0431	NADPH-dependent FMN reductase
LF543_RS00145	COG2235	arginine
LF543_RS00155	COG0531	amino acid
LF543_RS00170	COG4221	oxidoreductase activity
LF543_RS00180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LF543_RS00195	COG1473	amidohydrolase
LF543_RS00220	COG0028	Belongs to the TPP enzyme family
LF543_RS00235	COG0679	Auxin Efflux Carrier
LF543_RS00240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF543_RS00255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LF543_RS00260	COG0366	Alpha amylase catalytic
LF543_RS00360	COG1929	Belongs to the glycerate kinase type-1 family
LF543_RS00365	COG3764	Sortase (surface protein transpeptidase)
LF543_RS00400	COG0693	protein deglycase activity
LF543_RS00405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LF543_RS00410	COG0540	Belongs to the ATCase OTCase family
LF543_RS00415	COG0167	dihydroorotate dehydrogenase activity
LF543_RS00420	COG2235	arginine
LF543_RS00455	COG2814	Major facilitator Superfamily
LF543_RS00460	COG2309	aminopeptidase activity
LF543_RS00465	COG1442	glycosyl transferase family 8
LF543_RS00480	COG0142	geranyltranstransferase activity
LF543_RS00485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LF543_RS00490	COG4988	ABC transporter
LF543_RS00495	COG1294	oxidase, subunit
LF543_RS00500	COG1271	oxidase subunit
LF543_RS00505	COG1252	NADH dehydrogenase
LF543_RS00530	COG0110	maltose O-acetyltransferase activity
LF543_RS00545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LF543_RS00550	COG1368	sulfuric ester hydrolase activity
LF543_RS00555	COG2070	2-Nitropropane dioxygenase
LF543_RS00575	COG1609	Transcriptional regulator
LF543_RS00590	COG0519	Catalyzes the synthesis of GMP from XMP
LF543_RS00595	COG0516	GMP reductase activity
LF543_RS00595	COG0517	IMP dehydrogenase activity
LF543_RS00600	COG0124	histidyl-tRNA synthetase
LF543_RS00610	COG0586	Pfam SNARE associated Golgi protein
LF543_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
LF543_RS00655	COG1609	Transcriptional regulator
LF543_RS00670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LF543_RS00675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF543_RS00680	COG0531	amino acid
LF543_RS00710	COG4608	Belongs to the ABC transporter superfamily
LF543_RS00715	COG0444	Belongs to the ABC transporter superfamily
LF543_RS00720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LF543_RS00725	COG0601	transmembrane transport
LF543_RS00730	COG4166	transmembrane transport
LF543_RS00745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LF543_RS00775	COG2755	lipolytic protein G-D-S-L family
LF543_RS00775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LF543_RS00785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LF543_RS00790	COG1316	TRANSCRIPTIONal
LF543_RS00795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LF543_RS00805	COG0463	Glycosyl transferase, family 2
LF543_RS00815	COG0562	UDP-galactopyranose mutase
LF543_RS00820	COG2244	polysaccharide biosynthetic process
LF543_RS00830	COG0438	transferase activity, transferring glycosyl groups
LF543_RS00850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF543_RS00855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF543_RS00935	COG1070	Carbohydrate kinase
LF543_RS00945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LF543_RS00970	COG0702	epimerase
LF543_RS00990	COG0588	phosphoglycerate mutase activity
LF543_RS01000	COG2315	Protein conserved in bacteria
LF543_RS01005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LF543_RS01010	COG1268	BioY protein
LF543_RS01025	COG0765	amino acid transport
LF543_RS01030	COG0765	amino acid transport
LF543_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF543_RS01050	COG2814	Major facilitator Superfamily
LF543_RS01055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LF543_RS01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LF543_RS01075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LF543_RS01080	COG0697	spore germination
LF543_RS01085	COG2409	Drug exporters of the RND superfamily
LF543_RS01085	COG1033	growth of symbiont in host cell
LF543_RS01090	COG0697	spore germination
LF543_RS01100	COG0697	spore germination
LF543_RS01120	COG2814	Major facilitator Superfamily
LF543_RS01130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LF543_RS01135	COG1064	alcohol dehydrogenase
LF543_RS01145	COG0656	L-ascorbic acid biosynthetic process
LF543_RS01165	COG0667	Aldo Keto reductase
LF543_RS01170	COG3189	MarR family transcriptional regulator
LF543_RS01180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LF543_RS01185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LF543_RS01190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LF543_RS01195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LF543_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
LF543_RS01205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LF543_RS01210	COG0511	ligase activity, forming carbon-carbon bonds
LF543_RS01220	COG0439	Biotin carboxylase
LF543_RS01225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LF543_RS01230	COG0825	malonyl-CoA metabolic process
LF543_RS01235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LF543_RS01240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LF543_RS01245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LF543_RS01250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LF543_RS01255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LF543_RS01260	COG0511	ligase activity, forming carbon-carbon bonds
LF543_RS01265	COG0439	Biotin carboxylase
LF543_RS01270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LF543_RS01275	COG0825	malonyl-CoA metabolic process
LF543_RS01285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LF543_RS01285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LF543_RS01290	COG0006	proline dipeptidase activity
LF543_RS01300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LF543_RS01335	COG1278	Cold shock
LF543_RS01340	COG2249	NAD(P)H dehydrogenase (quinone) activity
LF543_RS01350	COG0456	acetyltransferase
LF543_RS01370	COG0351	phosphomethylpyrimidine kinase
LF543_RS01375	COG1063	alcohol dehydrogenase
LF543_RS01390	COG0328	RNA-DNA hybrid ribonuclease activity
LF543_RS01410	COG2094	Belongs to the DNA glycosylase MPG family
LF543_RS01420	COG0024	Methionine aminopeptidase
LF543_RS01455	COG3590	peptidase
LF543_RS01485	COG0735	belongs to the Fur family
LF543_RS01520	COG1122	ATPase activity
LF543_RS01550	COG0300	oxidoreductase activity
LF543_RS01555	COG1335	isochorismatase
LF543_RS01565	COG0351	phosphomethylpyrimidine kinase
LF543_RS01570	COG0352	thiamine-phosphate diphosphorylase activity
LF543_RS01575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LF543_RS01600	COG1881	PFAM PEBP family protein
LF543_RS01610	COG0531	amino acid
LF543_RS01620	COG0488	(ABC) transporter
LF543_RS01650	COG0194	GDP metabolic process
LF543_RS01665	COG0531	amino acid
LF543_RS01670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LF543_RS01675	COG0588	phosphoglycerate mutase activity
LF543_RS01680	COG0569	domain protein
LF543_RS01680	COG0475	glutathione-regulated potassium exporter activity
LF543_RS01685	COG3973	AAA domain
LF543_RS01690	COG1072	(Pantothenic acid kinase))
LF543_RS01710	COG0564	pseudouridine synthase activity
LF543_RS01750	COG0527	aspartate kinase activity
LF543_RS01760	COG2171	N-acyltransferase activity
LF543_RS01765	COG1473	amidohydrolase
LF543_RS01770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LF543_RS01775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LF543_RS01780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LF543_RS01785	COG0436	Aminotransferase
LF543_RS01795	COG0730	response to heat
LF543_RS01805	COG0833	amino acid
LF543_RS01810	COG1428	Deoxynucleoside kinase
LF543_RS01815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LF543_RS01855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LF543_RS01875	COG4463	regulation of RNA biosynthetic process
LF543_RS01880	COG0542	response to heat
LF543_RS01885	COG0085	RNA polymerase activity
LF543_RS01890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LF543_RS01895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF543_RS01900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LF543_RS01905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LF543_RS01915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LF543_RS01920	COG0051	transcription antitermination factor activity, RNA binding
LF543_RS01925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LF543_RS01930	COG0088	Forms part of the polypeptide exit tunnel
LF543_RS01935	COG0089	rRNA binding
LF543_RS01940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LF543_RS01950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LF543_RS01955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LF543_RS01960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LF543_RS01965	COG0255	Belongs to the universal ribosomal protein uL29 family
LF543_RS01970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LF543_RS01975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LF543_RS01980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LF543_RS01985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LF543_RS01990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LF543_RS01995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LF543_RS02000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LF543_RS02010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LF543_RS02015	COG1841	ribosomal large subunit assembly
LF543_RS02020	COG0200	Binds to the 23S rRNA
LF543_RS02035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LF543_RS02040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LF543_RS02045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LF543_RS02050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LF543_RS02055	COG0202	RNA polymerase activity
LF543_RS02060	COG0203	ribosomal protein L17
LF543_RS02065	COG1122	ATPase activity
LF543_RS02070	COG1122	ATPase activity
LF543_RS02080	COG0101	tRNA pseudouridine synthase activity
LF543_RS02085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LF543_RS02090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LF543_RS02095	COG4684	Psort location CytoplasmicMembrane, score
LF543_RS02105	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF543_RS02110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LF543_RS02120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LF543_RS02125	COG4851	CamS sex pheromone cAM373 precursor
LF543_RS02130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LF543_RS02140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LF543_RS02145	COG1597	lipid kinase activity
LF543_RS02150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LF543_RS02155	COG0531	amino acid
LF543_RS02170	COG0673	inositol 2-dehydrogenase activity
LF543_RS02185	COG4975	Glucose uptake
LF543_RS02190	COG4975	Glucose uptake
LF543_RS02195	COG2610	gluconate transmembrane transporter activity
LF543_RS02200	COG0463	Glycosyl transferase, family 2
LF543_RS02205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LF543_RS02210	COG1295	ribonuclease BN
LF543_RS02215	COG0716	FMN binding
LF543_RS02220	COG2137	regulation of response to DNA damage stimulus
LF543_RS02225	COG0628	permease
LF543_RS02230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LF543_RS02240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LF543_RS02260	COG0542	response to heat
LF543_RS02275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LF543_RS02280	COG0438	transferase activity, transferring glycosyl groups
LF543_RS02285	COG0438	transferase activity, transferring glycosyl groups
LF543_RS02295	COG1368	sulfuric ester hydrolase activity
LF543_RS02385	COG0402	S-adenosylhomocysteine deaminase activity
LF543_RS02395	COG2233	PERMEase
LF543_RS02400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF543_RS02405	COG0765	amino acid transport
LF543_RS02410	COG1126	abc transporter atp-binding protein
LF543_RS02420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LF543_RS02425	COG0477	Major facilitator Superfamily
LF543_RS02430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LF543_RS02435	COG0495	leucyl-tRNA aminoacylation
LF543_RS02440	COG2244	polysaccharide biosynthetic process
LF543_RS02445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LF543_RS02455	COG1428	Deoxynucleoside kinase
LF543_RS02470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LF543_RS02485	COG1442	glycosyl transferase family 8
LF543_RS02490	COG0582	viral genome integration into host DNA
LF543_RS02735	COG1846	Transcriptional regulator
LF543_RS02765	COG0018	arginyl-trna synthetase
LF543_RS02770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LF543_RS02775	COG3679	Belongs to the UPF0342 family
LF543_RS02780	COG0420	3'-5' exonuclease activity
LF543_RS02785	COG4717	serine-type aminopeptidase activity
LF543_RS02805	COG0537	adenosine 5'-monophosphoramidase activity
LF543_RS02810	COG1131	(ABC) transporter
LF543_RS02820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LF543_RS02830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LF543_RS02835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF543_RS02840	COG1674	ftsk spoiiie
LF543_RS02845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LF543_RS02855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LF543_RS02855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LF543_RS02860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LF543_RS02865	COG0237	dephospho-CoA kinase activity
LF543_RS02870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LF543_RS02880	COG1484	DNA-dependent DNA replication
LF543_RS02885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LF543_RS02890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LF543_RS02895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LF543_RS02900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LF543_RS02905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LF543_RS02910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LF543_RS02915	COG1534	Rna-binding protein
LF543_RS02920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LF543_RS02930	COG0799	negative regulation of ribosome biogenesis
LF543_RS02935	COG2226	methyltransferase
LF543_RS02940	COG1323	Belongs to the UPF0348 family
LF543_RS02950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LF543_RS02955	COG0706	membrane insertase activity
LF543_RS02965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LF543_RS02980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LF543_RS02985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF543_RS02985	COG0072	phenylalanine-tRNA ligase activity
LF543_RS02990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LF543_RS02995	COG0572	uridine kinase
LF543_RS03000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LF543_RS03010	COG0768	penicillin binding
LF543_RS03015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LF543_RS03020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LF543_RS03025	COG0457	Tetratricopeptide repeat
LF543_RS03025	COG0705	Rhomboid family
LF543_RS03035	COG1940	carbohydrate kinase activity
LF543_RS03050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LF543_RS03065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LF543_RS03075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LF543_RS03080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LF543_RS03085	COG1302	Protein conserved in bacteria
LF543_RS03090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LF543_RS03095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LF543_RS03100	COG1570	exodeoxyribonuclease VII activity
LF543_RS03105	COG1722	exodeoxyribonuclease VII activity
LF543_RS03110	COG0142	geranyltranstransferase activity
LF543_RS03115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LF543_RS03120	COG0497	DNA recombination
LF543_RS03130	COG1758	RNA polymerase activity
LF543_RS03135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LF543_RS03140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LF543_RS03145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LF543_RS03155	COG1162	GTPase activity
LF543_RS03160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LF543_RS03170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LF543_RS03175	COG1302	Protein conserved in bacteria
LF543_RS03180	COG1461	Dihydroxyacetone kinase
LF543_RS03185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LF543_RS03190	COG0416	fatty acid biosynthetic process
LF543_RS03200	COG0571	ribonuclease III activity
LF543_RS03205	COG1196	nuclear chromosome segregation
LF543_RS03210	COG0552	protein localization to endoplasmic reticulum
LF543_RS03215	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LF543_RS03220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LF543_RS03225	COG0228	four-way junction DNA binding
LF543_RS03230	COG1837	Belongs to the UPF0109 family
LF543_RS03235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LF543_RS03240	COG0336	Belongs to the RNA methyltransferase TrmD family
LF543_RS03245	COG0335	large ribosomal subunit rRNA binding
LF543_RS03260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LF543_RS03265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LF543_RS03265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LF543_RS03270	COG1304	FMN binding
LF543_RS03290	COG1199	ATP-dependent helicase activity
LF543_RS03290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LF543_RS03310	COG3331	DNA recombination
LF543_RS03315	COG4474	Belongs to the UPF0398 family
LF543_RS03320	COG3599	regulation of cell shape
LF543_RS03330	COG0116	Belongs to the methyltransferase superfamily
LF543_RS03335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LF543_RS03340	COG0328	RNA-DNA hybrid ribonuclease activity
LF543_RS03350	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LF543_RS03355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LF543_RS03360	COG0564	pseudouridine synthase activity
LF543_RS03365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LF543_RS03370	COG0505	Belongs to the CarA family
LF543_RS03375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LF543_RS03380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LF543_RS03390	COG1307	EDD domain protein, DegV family
LF543_RS03395	COG4720	Psort location CytoplasmicMembrane, score
LF543_RS03415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LF543_RS03420	COG1227	inorganic diphosphatase activity
LF543_RS03425	COG0583	DNA-binding transcription factor activity
LF543_RS03435	COG0187	DNA topoisomerase II activity
LF543_RS03440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LF543_RS03450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LF543_RS03455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LF543_RS03460	COG4974	Belongs to the 'phage' integrase family
LF543_RS03465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LF543_RS03470	COG0758	DNA mediated transformation
LF543_RS03475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LF543_RS03485	COG4479	Belongs to the UPF0346 family
LF543_RS03490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LF543_RS03495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LF543_RS03500	COG0488	(ABC) transporter
LF543_RS03525	COG1160	GTP binding
LF543_RS03530	COG0539	negative regulation of cytoplasmic translation
LF543_RS03535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LF543_RS03545	COG0514	ATP-dependent DNA helicase (RecQ)
LF543_RS03555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LF543_RS03560	COG1187	pseudouridine synthase activity
LF543_RS03565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LF543_RS03595	COG0587	DNA-directed DNA polymerase activity
LF543_RS03610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LF543_RS03615	COG2384	SAM-dependent methyltransferase
LF543_RS03620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LF543_RS03625	COG0358	DNA primase activity
LF543_RS03630	COG0751	glycine-tRNA ligase activity
LF543_RS03635	COG0752	glycyl-tRNA synthetase alpha subunit
LF543_RS03640	COG1381	Involved in DNA repair and RecF pathway recombination
LF543_RS03645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LF543_RS03655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LF543_RS03660	COG1702	phosphate starvation-inducible protein PhoH
LF543_RS03665	COG1610	YqeY-like protein
LF543_RS03670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LF543_RS03675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LF543_RS03680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LF543_RS03685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LF543_RS03690	COG1682	transport, permease protein
LF543_RS03700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LF543_RS03705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LF543_RS03710	COG4991	sh3 domain protein
LF543_RS03710	COG3103	Sh3 type 3 domain protein
LF543_RS03710	COG0860	N-Acetylmuramoyl-L-alanine amidase
LF543_RS03715	COG3001	Fructosamine kinase
LF543_RS03720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LF543_RS03725	COG1490	D-aminoacyl-tRNA deacylase activity
LF543_RS03730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LF543_RS03735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LF543_RS03740	COG2264	protein methyltransferase activity
LF543_RS03765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LF543_RS03795	COG0481	GTPase activity
LF543_RS03800	COG0484	heat shock protein binding
LF543_RS03820	COG0196	riboflavin kinase activity
LF543_RS03825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LF543_RS03830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LF543_RS03835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LF543_RS03845	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LF543_RS03850	COG0195	Participates in both transcription termination and antitermination
LF543_RS03860	COG2176	DNA-directed DNA polymerase activity
LF543_RS03865	COG0442	prolyl-tRNA aminoacylation
LF543_RS03870	COG0750	zinc metalloprotease
LF543_RS03875	COG4589	Belongs to the CDS family
LF543_RS03880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LF543_RS03895	COG0528	UMP kinase activity
LF543_RS03900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LF543_RS03905	COG0052	Belongs to the universal ribosomal protein uS2 family
LF543_RS03920	COG2827	Endonuclease containing a URI domain
LF543_RS03925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LF543_RS03930	COG0204	Acyl-transferase
LF543_RS03935	COG3763	UPF0154 protein
LF543_RS03950	COG3425	synthase
LF543_RS03955	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LF543_RS03975	COG3052	prosthetic group binding
LF543_RS03990	COG0281	malic enzyme
LF543_RS04005	COG0446	pyridine nucleotide-disulphide oxidoreductase
LF543_RS04015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LF543_RS04020	COG0657	acetylesterase activity
LF543_RS04030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF543_RS04035	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LF543_RS04035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LF543_RS04045	COG1234	tRNA 3'-trailer cleavage
LF543_RS04060	COG0322	excinuclease ABC activity
LF543_RS04065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LF543_RS04070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LF543_RS04075	COG0544	peptidyl-prolyl cis-trans isomerase activity
LF543_RS04080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LF543_RS04095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LF543_RS04100	COG0268	Binds directly to 16S ribosomal RNA
LF543_RS04105	COG1466	dna polymerase III delta subunit
LF543_RS04110	COG2333	competence protein COMEC
LF543_RS04110	COG0658	competence protein
LF543_RS04115	COG2131	deaminase
LF543_RS04120	COG1555	photosystem II stabilization
LF543_RS04120	COG1596	polysaccharide export
LF543_RS04125	COG3480	Lon protease (S16) C-terminal proteolytic domain
LF543_RS04130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LF543_RS04135	COG0742	ribosomal rna small subunit methyltransferase
LF543_RS04140	COG4471	UPF0298 protein
LF543_RS04145	COG0772	Belongs to the SEDS family
LF543_RS04150	COG1217	gtp-binding protein TYPA
LF543_RS04155	COG0483	inositol monophosphate 1-phosphatase activity
LF543_RS04160	COG4476	Belongs to the UPF0223 family
LF543_RS04165	COG0039	L-malate dehydrogenase activity
LF543_RS04170	COG0242	peptide deformylase activity
LF543_RS04180	COG5503	Protein of unknown function (DUF1447)
LF543_RS04190	COG0667	Aldo Keto reductase
LF543_RS04195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LF543_RS04200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LF543_RS04210	COG0406	alpha-ribazole phosphatase activity
LF543_RS04215	COG0482	sulfurtransferase activity
LF543_RS04225	COG1104	cysteine desulfurase activity
LF543_RS04245	COG1278	Cold shock
LF543_RS04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LF543_RS04255	COG3599	regulation of cell shape
LF543_RS04270	COG1799	cell septum assembly
LF543_RS04275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LF543_RS04285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LF543_RS04290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LF543_RS04295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LF543_RS04300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LF543_RS04305	COG0768	penicillin binding
LF543_RS04315	COG0275	rRNA processing
LF543_RS04320	COG2001	Belongs to the MraZ family
LF543_RS04335	COG1674	ftsk spoiiie
LF543_RS04355	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF543_RS04360	COG0564	pseudouridine synthase activity
LF543_RS04365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LF543_RS04370	COG2357	RelA SpoT domain protein
LF543_RS04380	COG0656	L-ascorbic acid biosynthetic process
LF543_RS04395	COG4862	establishment of competence for transformation
LF543_RS04400	COG1234	tRNA 3'-trailer cleavage
LF543_RS04520	COG0586	Pfam SNARE associated Golgi protein
LF543_RS04535	COG4470	Protein conserved in bacteria
LF543_RS04540	COG0737	Belongs to the 5'-nucleotidase family
LF543_RS04545	COG1113	amino acid transport
LF543_RS04555	COG0827	DNA restriction-modification system
LF543_RS04570	COG4537	Required for transformation and DNA binding
LF543_RS04585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LF543_RS04590	COG0217	transcriptional regulatory protein
LF543_RS04595	COG1609	Transcriptional regulator
LF543_RS04610	COG0668	transmembrane transport
LF543_RS04615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LF543_RS04620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LF543_RS04625	COG1719	4-vinyl reductase, 4VR
LF543_RS04630	COG3118	belongs to the thioredoxin family
LF543_RS04635	COG1193	negative regulation of DNA recombination
LF543_RS04650	COG3906	Belongs to the UPF0473 family
LF543_RS04660	COG4472	Bacterial protein of unknown function (DUF965)
LF543_RS04665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LF543_RS04670	COG0513	Belongs to the DEAD box helicase family
LF543_RS04675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LF543_RS04680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LF543_RS04685	COG1862	Preprotein translocase
LF543_RS04690	COG2255	four-way junction helicase activity
LF543_RS04695	COG0632	four-way junction helicase activity
LF543_RS04700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LF543_RS04705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LF543_RS04710	COG1692	metallophosphoesterase
LF543_RS04715	COG1418	mRNA catabolic process
LF543_RS04720	COG1546	Belongs to the CinA family
LF543_RS04720	COG1058	Belongs to the CinA family
LF543_RS04725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LF543_RS04730	COG1426	Protein conserved in bacteria
LF543_RS04735	COG0612	Peptidase, M16
LF543_RS04745	COG2894	cell division
LF543_RS04750	COG0850	regulation of cytokinetic process
LF543_RS04760	COG1792	Involved in formation and maintenance of cell shape
LF543_RS04765	COG1077	Cell shape determining protein MreB Mrl
LF543_RS04770	COG0285	dihydrofolate synthase activity
LF543_RS04775	COG0525	valine-tRNA ligase activity
LF543_RS04780	COG0301	tRNA thio-modification
LF543_RS04785	COG1104	cysteine desulfurase activity
LF543_RS04790	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LF543_RS04795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LF543_RS04805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LF543_RS04825	COG1181	Belongs to the D-alanine--D-alanine ligase family
LF543_RS04830	COG0772	Belongs to the SEDS family
LF543_RS04840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LF543_RS04850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LF543_RS04860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LF543_RS04865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LF543_RS04870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LF543_RS04880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LF543_RS04885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LF543_RS04890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LF543_RS04895	COG0356	it plays a direct role in the translocation of protons across the membrane
LF543_RS04900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LF543_RS04905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LF543_RS04910	COG0009	L-threonylcarbamoyladenylate synthase
LF543_RS04915	COG2890	protein-(glutamine-N5) methyltransferase activity
LF543_RS04925	COG1435	thymidine kinase activity
LF543_RS04930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LF543_RS04935	COG3442	glutamine amidotransferase
LF543_RS04945	COG2936	dipeptidyl-peptidase activity
LF543_RS04950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LF543_RS04955	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LF543_RS04975	COG0484	heat shock protein binding
LF543_RS04980	COG0791	NLP P60 protein
LF543_RS04980	COG1388	LysM domain
LF543_RS04980	COG3103	Sh3 type 3 domain protein
LF543_RS04990	COG0166	Belongs to the GPI family
LF543_RS04995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LF543_RS05000	COG0561	phosphatase activity
LF543_RS05020	COG2814	Major facilitator Superfamily
LF543_RS05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
LF543_RS05065	COG0640	Transcriptional regulator
LF543_RS05075	COG0561	phosphatase activity
LF543_RS05080	COG2706	6-phosphogluconolactonase activity
LF543_RS05090	COG1134	teichoic acid transport
LF543_RS05095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LF543_RS05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LF543_RS05125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LF543_RS05130	COG0708	Exodeoxyribonuclease III
LF543_RS05135	COG2176	DNA-directed DNA polymerase activity
LF543_RS05145	COG0802	atpase or kinase
LF543_RS05150	COG0280	phosphate acetyltransferase
LF543_RS05155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LF543_RS05160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LF543_RS05165	COG0557	exoribonuclease II activity
LF543_RS05170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LF543_RS05180	COG0148	phosphopyruvate hydratase activity
LF543_RS05185	COG0149	triose-phosphate isomerase activity
LF543_RS05190	COG0126	phosphoglycerate kinase activity
LF543_RS05205	COG1396	sequence-specific DNA binding
LF543_RS05210	COG0367	asparagine synthase
LF543_RS05215	COG0740	serine-type endopeptidase activity
LF543_RS05220	COG1481	regulation of sporulation
LF543_RS05225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LF543_RS05230	COG1660	Displays ATPase and GTPase activities
LF543_RS05240	COG2706	6-phosphogluconolactonase activity
LF543_RS05255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LF543_RS05260	COG0556	nucleotide-excision repair
LF543_RS05265	COG0492	ferredoxin-NADP+ reductase activity
LF543_RS05275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LF543_RS05280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LF543_RS05285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LF543_RS05290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LF543_RS05295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LF543_RS05305	COG0653	protein targeting
LF543_RS05315	COG1040	competence protein
LF543_RS05320	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LF543_RS05325	COG1739	Uncharacterized protein family UPF0029
LF543_RS05330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LF543_RS05335	COG1380	Effector of murein hydrolase LrgA
LF543_RS05340	COG1346	cytolysis
LF543_RS05345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LF543_RS05350	COG0531	amino acid
LF543_RS05355	COG0459	protein refolding
LF543_RS05360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LF543_RS05365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LF543_RS05370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LF543_RS05380	COG1214	PFAM Peptidase M22, glycoprotease
LF543_RS05395	COG4467	Involved in initiation control of chromosome replication
LF543_RS05400	COG0470	DNA polymerase III
LF543_RS05405	COG3870	Protein conserved in bacteria
LF543_RS05410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LF543_RS05420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LF543_RS05430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LF543_RS05445	COG2813	Specifically methylates the guanine in position
LF543_RS05450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LF543_RS05455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF543_RS05460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF543_RS05465	COG0392	lysyltransferase activity
LF543_RS05465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LF543_RS05470	COG0222	ribosome binding
LF543_RS05475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LF543_RS05480	COG0081	regulation of translation
LF543_RS05485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LF543_RS05490	COG0250	Participates in transcription elongation, termination and antitermination
LF543_RS05500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LF543_RS05510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LF543_RS05515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LF543_RS05520	COG0215	cysteine-tRNA ligase activity
LF543_RS05525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LF543_RS05530	COG0756	dUTP diphosphatase activity
LF543_RS05535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LF543_RS05540	COG0588	phosphoglycerate mutase activity
LF543_RS05555	COG1316	TRANSCRIPTIONal
LF543_RS05570	COG0083	homoserine kinase activity
LF543_RS05575	COG3091	SprT-like family
LF543_RS05580	COG2183	response to ionizing radiation
LF543_RS05585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LF543_RS05590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LF543_RS05600	COG2188	Transcriptional regulator
LF543_RS05615	COG3104	oligopeptide transport
LF543_RS05620	COG1970	mechanosensitive ion channel activity
LF543_RS05625	COG0174	glutamine synthetase
LF543_RS05630	COG0789	Transcriptional regulator
LF543_RS05670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LF543_RS05675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LF543_RS05680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LF543_RS05695	COG0037	tRNA processing
LF543_RS05700	COG1098	S1 RNA binding domain
LF543_RS05710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LF543_RS05715	COG2244	polysaccharide biosynthetic process
LF543_RS05720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LF543_RS05725	COG0193	aminoacyl-tRNA hydrolase activity
LF543_RS05730	COG0039	L-malate dehydrogenase activity
LF543_RS05740	COG2337	Toxic component of a toxin-antitoxin (TA) module
LF543_RS05750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LF543_RS05760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LF543_RS05770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LF543_RS05780	COG0254	rRNA binding
LF543_RS05785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LF543_RS05790	COG0504	CTP synthase activity
LF543_RS05795	COG3343	RNA polymerase activity
LF543_RS05805	COG1078	dGTPase activity
LF543_RS05810	COG0561	phosphatase activity
LF543_RS05815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LF543_RS05820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LF543_RS05825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF543_RS05830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LF543_RS05835	COG1121	(ABC) transporter
LF543_RS05845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LF543_RS05855	COG0084	hydrolase, TatD family'
LF543_RS05860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF543_RS05860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF543_RS05865	COG1801	Protein of unknown function DUF72
LF543_RS05870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LF543_RS05885	COG0248	Ppx GppA phosphatase
LF543_RS05895	COG3973	AAA domain
LF543_RS05915	COG2814	Major facilitator Superfamily
LF543_RS05925	COG0588	phosphoglycerate mutase activity
LF543_RS05930	COG0628	permease
LF543_RS05935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LF543_RS05950	COG1686	Belongs to the peptidase S11 family
LF543_RS05970	COG0012	GTP binding
LF543_RS05975	COG4481	Protein conserved in bacteria
LF543_RS05980	COG1475	DNA binding
LF543_RS05985	COG1192	Involved in chromosome partitioning
LF543_RS05990	COG0357	Ribosomal RNA small subunit methyltransferase G
LF543_RS06000	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LF543_RS06035	COG1388	LysM domain
LF543_RS06060	COG0745	RESPONSE REGULATOR receiver
LF543_RS06065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LF543_RS06070	COG0573	inorganic phosphate transmembrane transporter activity
LF543_RS06075	COG0581	inorganic phosphate transmembrane transporter activity
LF543_RS06085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LF543_RS06090	COG0704	Plays a role in the regulation of phosphate uptake
LF543_RS06095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LF543_RS06100	COG1136	(ABC) transporter
LF543_RS06100	COG0577	efflux transmembrane transporter activity
LF543_RS06105	COG1063	alcohol dehydrogenase
LF543_RS06115	COG0028	Belongs to the TPP enzyme family
LF543_RS06120	COG0390	transport system, permease component
LF543_RS06125	COG4619	ABC transporter
LF543_RS06130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LF543_RS06145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LF543_RS06155	COG2365	Tyrosine phosphatase family
LF543_RS06170	COG3118	belongs to the thioredoxin family
LF543_RS06175	COG0861	Integral membrane protein TerC family
LF543_RS06180	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF543_RS06205	COG0406	alpha-ribazole phosphatase activity
LF543_RS06210	COG1368	sulfuric ester hydrolase activity
LF543_RS06220	COG1482	cell wall glycoprotein biosynthetic process
LF543_RS06225	COG0492	ferredoxin-NADP+ reductase activity
LF543_RS06235	COG0561	phosphatase activity
LF543_RS06240	COG1393	Belongs to the ArsC family
LF543_RS06245	COG0737	Belongs to the 5'-nucleotidase family
LF543_RS06250	COG1418	mRNA catabolic process
LF543_RS06280	COG0564	pseudouridine synthase activity
LF543_RS06290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LF543_RS06295	COG2188	Transcriptional regulator
LF543_RS06305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LF543_RS06310	COG1418	mRNA catabolic process
LF543_RS06335	COG1454	alcohol dehydrogenase
LF543_RS06335	COG1012	belongs to the aldehyde dehydrogenase family
LF543_RS06340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LF543_RS06345	COG0071	Belongs to the small heat shock protein (HSP20) family
LF543_RS06350	COG1253	flavin adenine dinucleotide binding
LF543_RS06360	COG1780	Probably involved in ribonucleotide reductase function
LF543_RS06365	COG0446	pyridine nucleotide-disulphide oxidoreductase
LF543_RS06380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LF543_RS06385	COG2814	Major facilitator Superfamily
LF543_RS06405	COG1132	(ABC) transporter
LF543_RS06410	COG0531	amino acid
LF543_RS06420	COG1733	regulation of RNA biosynthetic process
LF543_RS06430	COG1620	l-lactate permease
LF543_RS06495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LF543_RS06510	COG2814	Major facilitator Superfamily
LF543_RS06515	COG0737	Belongs to the 5'-nucleotidase family
LF543_RS06520	COG1126	abc transporter atp-binding protein
LF543_RS06525	COG0765	amino acid transport
LF543_RS06530	COG0165	Argininosuccinate lyase
LF543_RS06535	COG0137	argininosuccinate synthase activity
LF543_RS06540	COG0531	amino acid
LF543_RS06550	COG1301	dicarboxylic acid transport
LF543_RS06575	COG0183	Belongs to the thiolase family
LF543_RS06580	COG1114	Component of the transport system for branched-chain amino acids
LF543_RS06605	COG3409	Peptidoglycan-binding domain 1 protein
LF543_RS06630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LF543_RS06645	COG1074	ATP-dependent DNA helicase activity
LF543_RS06650	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LF543_RS06660	COG2252	PERMEase
LF543_RS06665	COG1012	belongs to the aldehyde dehydrogenase family
LF543_RS06695	COG3579	cysteine-type endopeptidase activity
LF543_RS06710	COG2814	Major facilitator Superfamily
LF543_RS06720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LF543_RS06735	COG1309	transcriptional regulator
LF543_RS06740	COG0300	oxidoreductase activity
LF543_RS06745	COG0604	alcohol dehydrogenase
LF543_RS06760	COG1063	alcohol dehydrogenase
LF543_RS06775	COG0004	ammonium transporteR
LF543_RS06780	COG4221	oxidoreductase activity
LF543_RS06785	COG4221	oxidoreductase activity
LF543_RS06800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LF543_RS06815	COG0789	Transcriptional regulator
LF543_RS06825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LF543_RS06830	COG0656	L-ascorbic acid biosynthetic process
LF543_RS06835	COG1247	-acetyltransferase
LF543_RS06845	COG0626	cystathionine gamma-synthase activity
LF543_RS06880	COG0438	transferase activity, transferring glycosyl groups
LF543_RS06890	COG1073	alpha beta
LF543_RS06910	COG0653	protein targeting
LF543_RS06915	COG1686	Belongs to the peptidase S11 family
LF543_RS06925	COG4948	Mandelate Racemase Muconate Lactonizing
LF543_RS06940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LF543_RS06975	COG0445	tRNA wobble uridine modification
LF543_RS06990	COG0706	membrane insertase activity
LF543_RS06995	COG0594	ribonuclease P activity
LF543_RS07000	COG0230	Belongs to the bacterial ribosomal protein bL34 family