locus-tag	class	description
C4N16_RS00035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4N16_RS00040	COG2926	Belongs to the UPF0265 family
C4N16_RS00045	COG0205	6-phosphofructokinase activity
C4N16_RS00050	COG0825	malonyl-CoA metabolic process
C4N16_RS00055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4N16_RS00070	COG3872	metal-dependent enzyme
C4N16_RS00075	COG2208	phosphoserine phosphatase activity
C4N16_RS00080	COG0322	excinuclease ABC activity
C4N16_RS00085	COG1660	Displays ATPase and GTPase activities
C4N16_RS00110	COG0783	Belongs to the Dps family
C4N16_RS00125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4N16_RS00135	COG0697	spore germination
C4N16_RS00145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4N16_RS00155	COG0285	dihydrofolate synthase activity
C4N16_RS00160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4N16_RS00165	COG1560	Kdo2-lipid A biosynthetic process
C4N16_RS00170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4N16_RS00175	COG1024	Enoyl-CoA hydratase
C4N16_RS00185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4N16_RS00190	COG4974	Belongs to the 'phage' integrase family
C4N16_RS00195	COG0497	DNA recombination
C4N16_RS00200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4N16_RS00215	COG3958	Transketolase
C4N16_RS00220	COG3959	Transketolase, thiamine diphosphate binding domain
C4N16_RS00230	COG0424	maF-like protein
C4N16_RS00245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4N16_RS00245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4N16_RS00250	COG2239	Acts as a magnesium transporter
C4N16_RS00270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4N16_RS00275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4N16_RS00280	COG0049	tRNA binding
C4N16_RS00285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4N16_RS00290	COG0488	(ABC) transporter
C4N16_RS00335	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4N16_RS00345	COG1797	cobyrinic acid a,c-diamide synthase activity
C4N16_RS00350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4N16_RS00375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C4N16_RS00380	COG0772	Belongs to the SEDS family
C4N16_RS00385	COG4224	UPF0291 protein
C4N16_RS00390	COG0017	Asparaginyl-tRNA synthetase
C4N16_RS00395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4N16_RS00415	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4N16_RS00415	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4N16_RS00415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4N16_RS00415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4N16_RS00425	COG0626	cystathionine gamma-synthase activity
C4N16_RS00430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N16_RS00455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4N16_RS00470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N16_RS00470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N16_RS00480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4N16_RS00485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4N16_RS00490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4N16_RS00495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4N16_RS00505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4N16_RS00530	COG2226	methyltransferase
C4N16_RS00535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N16_RS00545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4N16_RS00550	COG0456	acetyltransferase
C4N16_RS00555	COG0681	Belongs to the peptidase S26 family
C4N16_RS00560	COG0335	large ribosomal subunit rRNA binding
C4N16_RS00570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N16_RS00575	COG2011	ABC-type metal ion transport system permease component
C4N16_RS00600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4N16_RS00605	COG1121	(ABC) transporter
C4N16_RS00610	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4N16_RS00615	COG4221	oxidoreductase activity
C4N16_RS00630	COG0039	L-malate dehydrogenase activity
C4N16_RS00640	COG4206	TonB-dependent receptor
C4N16_RS00645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4N16_RS00650	COG0512	Glutamine amidotransferase of anthranilate synthase
C4N16_RS00650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4N16_RS00670	COG2252	PERMEase
C4N16_RS00675	COG0564	pseudouridine synthase activity
C4N16_RS00680	COG0772	Belongs to the SEDS family
C4N16_RS00685	COG0756	dUTP diphosphatase activity
C4N16_RS00690	COG0612	Peptidase, M16
C4N16_RS00715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4N16_RS00720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4N16_RS00725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4N16_RS00730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4N16_RS00735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4N16_RS00740	COG1137	ATPase activity
C4N16_RS00750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4N16_RS00755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4N16_RS00860	COG3210	domain, Protein
C4N16_RS00865	COG2831	hemolysin activation secretion protein
C4N16_RS00870	COG3951	Flagellar rod assembly protein muramidase FlgJ
C4N16_RS00870	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4N16_RS00880	COG4214	carbohydrate transport
C4N16_RS00890	COG1129	ABC transporter
C4N16_RS00895	COG1609	Transcriptional regulator
C4N16_RS00900	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4N16_RS00910	COG1758	RNA polymerase activity
C4N16_RS00915	COG0194	GDP metabolic process
C4N16_RS00920	COG1561	YicC-like family, N-terminal region
C4N16_RS00925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4N16_RS00930	COG0085	RNA polymerase activity
C4N16_RS00935	COG0222	ribosome binding
C4N16_RS00940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4N16_RS00945	COG0081	regulation of translation
C4N16_RS00950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4N16_RS00955	COG0250	Participates in transcription elongation, termination and antitermination
C4N16_RS00970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4N16_RS00980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N16_RS00990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4N16_RS01000	COG0598	Magnesium transport protein CorA
C4N16_RS01010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N16_RS01020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4N16_RS01040	COG0731	radical SAM domain protein
C4N16_RS01040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4N16_RS01045	COG0588	phosphoglycerate mutase activity
C4N16_RS01070	COG0470	DNA polymerase III
C4N16_RS01075	COG1077	Cell shape determining protein MreB Mrl
C4N16_RS01080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4N16_RS01085	COG0215	cysteine-tRNA ligase activity
C4N16_RS01090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4N16_RS01095	COG1193	negative regulation of DNA recombination
C4N16_RS01100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4N16_RS01105	COG1288	antiporter activity
C4N16_RS01110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N16_RS01120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4N16_RS01125	COG0360	Binds together with S18 to 16S ribosomal RNA
C4N16_RS01130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4N16_RS01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4N16_RS01150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4N16_RS01155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4N16_RS01160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4N16_RS01165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4N16_RS01170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4N16_RS01175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4N16_RS01180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4N16_RS01190	COG0495	leucyl-tRNA aminoacylation
C4N16_RS01195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4N16_RS01200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4N16_RS01210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4N16_RS01215	COG2137	regulation of response to DNA damage stimulus
C4N16_RS01220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4N16_RS01225	COG0859	PFAM glycosyl transferase family 9
C4N16_RS01245	COG0463	Glycosyl transferase, family 2
C4N16_RS01250	COG0726	polysaccharide deacetylase
C4N16_RS01335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4N16_RS01370	COG1115	amino acid carrier protein
C4N16_RS01375	COG2885	chlorophyll binding
C4N16_RS01380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4N16_RS01385	COG2986	histidine ammonia-lyase
C4N16_RS01395	COG2878	Part of a membrane complex involved in electron transport
C4N16_RS01395	COG1245	4Fe-4S binding domain
C4N16_RS01400	COG4657	Part of a membrane complex involved in electron transport
C4N16_RS01405	COG4660	Part of a membrane complex involved in electron transport
C4N16_RS01415	COG4658	electron transport chain
C4N16_RS01420	COG4656	Part of a membrane complex involved in electron transport
C4N16_RS01425	COG0193	aminoacyl-tRNA hydrolase activity
C4N16_RS01430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N16_RS01430	COG0072	phenylalanine-tRNA ligase activity
C4N16_RS01435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4N16_RS01445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4N16_RS01450	COG0187	DNA topoisomerase II activity
C4N16_RS01480	COG0594	ribonuclease P activity
C4N16_RS01485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4N16_RS01490	COG0706	membrane insertase activity
C4N16_RS01495	COG1847	R3H domain protein
C4N16_RS01500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4N16_RS01505	COG0445	tRNA wobble uridine modification
C4N16_RS01510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4N16_RS01515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4N16_RS01520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4N16_RS01525	COG2088	sporulation resulting in formation of a cellular spore
C4N16_RS01540	COG0166	Belongs to the GPI family
C4N16_RS01575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4N16_RS01630	COG1956	GAF domain-containing protein
C4N16_RS01660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4N16_RS01665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4N16_RS01670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4N16_RS01680	COG1136	(ABC) transporter
C4N16_RS01700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4N16_RS01705	COG0384	phenazine biosynthesis protein PhzF
C4N16_RS01725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4N16_RS01880	COG0740	serine-type endopeptidase activity
C4N16_RS02005	COG4824	toxin secretion phage lysis holin
C4N16_RS02010	COG0464	growth
C4N16_RS02035	COG3275	phosphorelay sensor kinase activity
C4N16_RS02040	COG3279	Response regulator of the LytR AlgR family
C4N16_RS02045	COG1966	Carbon starvation protein
C4N16_RS02050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4N16_RS02055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4N16_RS02060	COG2066	Belongs to the glutaminase family
C4N16_RS02075	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N16_RS02075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4N16_RS02075	COG0539	negative regulation of cytoplasmic translation
C4N16_RS02080	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N16_RS02080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4N16_RS02080	COG0539	negative regulation of cytoplasmic translation
C4N16_RS02105	COG0101	tRNA pseudouridine synthase activity
C4N16_RS02115	COG0735	belongs to the Fur family
C4N16_RS02120	COG2033	superoxide reductase activity
C4N16_RS02125	COG1227	inorganic diphosphatase activity
C4N16_RS02130	COG0051	transcription antitermination factor activity, RNA binding
C4N16_RS02135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4N16_RS02140	COG0088	Forms part of the polypeptide exit tunnel
C4N16_RS02145	COG0089	rRNA binding
C4N16_RS02150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4N16_RS02155	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4N16_RS02160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4N16_RS02165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4N16_RS02170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4N16_RS02175	COG0255	Belongs to the universal ribosomal protein uL29 family
C4N16_RS02180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4N16_RS02185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4N16_RS02195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4N16_RS02200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4N16_RS02205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4N16_RS02210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4N16_RS02215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4N16_RS02220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4N16_RS02225	COG1841	ribosomal large subunit assembly
C4N16_RS02230	COG0200	Binds to the 23S rRNA
C4N16_RS02235	COG0201	protein transport
C4N16_RS02245	COG0563	adenylate kinase activity
C4N16_RS02255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4N16_RS02265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4N16_RS02270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4N16_RS02275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4N16_RS02280	COG0202	RNA polymerase activity
C4N16_RS02285	COG0203	ribosomal protein L17
C4N16_RS02295	COG1309	transcriptional regulator
C4N16_RS02315	COG1278	Cold shock
C4N16_RS02325	COG0516	GMP reductase activity
C4N16_RS02325	COG0517	IMP dehydrogenase activity
C4N16_RS02340	COG1420	regulation of RNA biosynthetic process
C4N16_RS02350	COG0443	Heat shock 70 kDa protein
C4N16_RS02370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4N16_RS02380	COG1862	Preprotein translocase
C4N16_RS02395	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4N16_RS02400	COG0557	exoribonuclease II activity
C4N16_RS02405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4N16_RS02415	COG0052	Belongs to the universal ribosomal protein uS2 family
C4N16_RS02420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4N16_RS02425	COG0528	UMP kinase activity
C4N16_RS02430	COG0233	cytoplasmic translational termination
C4N16_RS02440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4N16_RS02445	COG4589	Belongs to the CDS family
C4N16_RS02450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4N16_RS02460	COG0750	zinc metalloprotease
C4N16_RS02465	COG2204	response regulator
C4N16_RS02470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4N16_RS02475	COG0358	DNA primase activity
C4N16_RS02480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N16_RS02485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N16_RS02490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4N16_RS02530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N16_RS02535	COG4604	ABC transporter, ATP-binding protein
C4N16_RS02555	COG5002	protein histidine kinase activity
C4N16_RS02560	COG0745	RESPONSE REGULATOR receiver
C4N16_RS02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N16_RS02570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C4N16_RS02580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4N16_RS02585	COG0281	malic enzyme
C4N16_RS02590	COG1704	LemA family
C4N16_RS02600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C4N16_RS02605	COG0442	prolyl-tRNA aminoacylation
C4N16_RS02610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4N16_RS02615	COG0217	transcriptional regulatory protein
C4N16_RS02650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4N16_RS02650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4N16_RS02655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4N16_RS02660	COG0534	Mate efflux family protein
C4N16_RS02665	COG0427	acetyl-CoA hydrolase
C4N16_RS02670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4N16_RS02675	COG2868	ribosomal protein
C4N16_RS02680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4N16_RS02685	COG0501	Belongs to the peptidase M48B family
C4N16_RS02730	COG4399	Belongs to the UPF0754 family
C4N16_RS02730	COG4399	Belongs to the UPF0754 family
C4N16_RS02735	COG2255	four-way junction helicase activity
C4N16_RS02740	COG1959	2 iron, 2 sulfur cluster binding
C4N16_RS02745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4N16_RS02750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N16_RS02765	COG0768	penicillin binding
C4N16_RS02770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4N16_RS02780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4N16_RS02790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4N16_RS02795	COG0793	Belongs to the peptidase S41A family
C4N16_RS02800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4N16_RS02805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N16_RS02810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4N16_RS02820	COG0716	FMN binding
C4N16_RS02825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4N16_RS02835	COG1032	radical SAM domain protein
C4N16_RS02840	COG1160	GTP binding
C4N16_RS02845	COG1114	Component of the transport system for branched-chain amino acids
C4N16_RS02850	COG1393	Belongs to the ArsC family
C4N16_RS02855	COG1114	Component of the transport system for branched-chain amino acids
C4N16_RS02865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N16_RS02870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N16_RS02880	COG0584	glycerophosphoryl diester phosphodiesterase
C4N16_RS02885	COG1846	Transcriptional regulator
C4N16_RS02890	COG0386	Belongs to the glutathione peroxidase family
C4N16_RS02900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4N16_RS02905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4N16_RS02905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4N16_RS02920	COG4868	Belongs to the UPF0371 family
C4N16_RS02930	COG0411	ABC transporter
C4N16_RS02950	COG0561	phosphatase activity
C4N16_RS02970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4N16_RS03000	COG0850	regulation of cytokinetic process
C4N16_RS03005	COG2894	cell division
C4N16_RS03010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4N16_RS03045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4N16_RS03050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4N16_RS03055	COG0009	L-threonylcarbamoyladenylate synthase
C4N16_RS03065	COG0180	Tryptophanyl-tRNA synthetase
C4N16_RS03070	COG1940	carbohydrate kinase activity
C4N16_RS03080	COG1129	ABC transporter
C4N16_RS03115	COG0564	pseudouridine synthase activity
C4N16_RS03120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4N16_RS03125	COG0792	nuclease activity
C4N16_RS03135	COG1040	competence protein
C4N16_RS03140	COG0149	triose-phosphate isomerase activity
C4N16_RS03150	COG1757	Na H antiporter
C4N16_RS03160	COG2848	UPF0210 protein
C4N16_RS03165	COG0012	GTP binding
C4N16_RS03170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4N16_RS03175	COG0416	fatty acid biosynthetic process
C4N16_RS03180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4N16_RS03185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4N16_RS03190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4N16_RS03195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4N16_RS03200	COG0571	ribonuclease III activity
C4N16_RS03210	COG1530	ribonuclease E activity
C4N16_RS03215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4N16_RS03220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4N16_RS03225	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4N16_RS03235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N16_RS03240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4N16_RS03245	COG0739	heme binding
C4N16_RS03250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4N16_RS03255	COG1595	DNA-templated transcription, initiation
C4N16_RS03270	COG0254	rRNA binding
C4N16_RS03275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4N16_RS03280	COG2608	mercury ion transmembrane transporter activity
C4N16_RS03285	COG2217	Heavy metal translocating P-type atpase
C4N16_RS03290	COG0295	cytidine deaminase activity
C4N16_RS03295	COG2031	fatty acid transporter
C4N16_RS03300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4N16_RS03315	COG0534	Mate efflux family protein
C4N16_RS03320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4N16_RS03325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4N16_RS03335	COG2996	Protein conserved in bacteria
C4N16_RS03360	COG1846	Transcriptional regulator
C4N16_RS03365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4N16_RS03370	COG1162	GTPase activity
C4N16_RS03385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4N16_RS03400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4N16_RS03405	COG0336	Belongs to the RNA methyltransferase TrmD family
C4N16_RS03410	COG4752	Belongs to the RNA methyltransferase TrmD family
C4N16_RS03425	COG2853	Lipoprotein
C4N16_RS03430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N16_RS03440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4N16_RS03445	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4N16_RS03485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4N16_RS03490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4N16_RS03495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4N16_RS03500	COG0003	Pfam Anion-transporting ATPase
C4N16_RS03505	COG0003	Pfam Anion-transporting ATPase
C4N16_RS03530	COG2226	methyltransferase
C4N16_RS03535	COG0644	oxidoreductase
C4N16_RS03545	COG1725	Transcriptional regulator
C4N16_RS03550	COG0277	FAD linked oxidase domain protein
C4N16_RS03565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4N16_RS03570	COG1380	Effector of murein hydrolase LrgA
C4N16_RS03575	COG1346	cytolysis
C4N16_RS03580	COG1757	Na H antiporter
C4N16_RS03585	COG1490	D-aminoacyl-tRNA deacylase activity
C4N16_RS03590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4N16_RS03595	COG0688	phosphatidylethanolamine metabolic process
C4N16_RS03610	COG0116	Belongs to the methyltransferase superfamily
C4N16_RS03620	COG2056	Na+-H+ antiporter family
C4N16_RS03630	COG1228	amidohydrolase
C4N16_RS03635	COG3404	Formiminotransferase-cyclodeaminase
C4N16_RS03650	COG1077	Cell shape determining protein MreB Mrl
C4N16_RS03660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4N16_RS03665	COG1187	pseudouridine synthase activity
C4N16_RS03670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4N16_RS03675	COG0154	amidase activity
C4N16_RS03680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4N16_RS03690	COG0646	methionine synthase
C4N16_RS03690	COG1410	methionine synthase
C4N16_RS03695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4N16_RS03700	COG3681	Belongs to the UPF0597 family
C4N16_RS03705	COG1960	acyl-CoA dehydrogenase activity
C4N16_RS03710	COG1773	rubredoxin
C4N16_RS03710	COG0426	domain, Protein
C4N16_RS03720	COG1151	hydroxylamine reductase activity
C4N16_RS03730	COG1827	regulation of RNA biosynthetic process
C4N16_RS03740	COG0488	(ABC) transporter
C4N16_RS03745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4N16_RS03750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4N16_RS03770	COG1418	mRNA catabolic process
C4N16_RS03775	COG1760	l-serine dehydratase
C4N16_RS03780	COG2990	Protein conserved in bacteria
C4N16_RS03785	COG2990	Protein conserved in bacteria
C4N16_RS03805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C4N16_RS03815	COG1940	carbohydrate kinase activity
C4N16_RS03825	COG0482	sulfurtransferase activity
C4N16_RS03830	COG1970	mechanosensitive ion channel activity
C4N16_RS03835	COG0351	phosphomethylpyrimidine kinase
C4N16_RS03835	COG0352	thiamine-phosphate diphosphorylase activity
C4N16_RS03840	COG0352	thiamine-phosphate diphosphorylase activity
C4N16_RS03855	COG2022	thiamine diphosphate biosynthetic process
C4N16_RS03865	COG1683	Conserved Protein
C4N16_RS03870	COG1196	nuclear chromosome segregation
C4N16_RS03895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4N16_RS03900	COG2890	protein-(glutamine-N5) methyltransferase activity
C4N16_RS03905	COG0742	ribosomal rna small subunit methyltransferase
C4N16_RS03910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4N16_RS03915	COG1722	exodeoxyribonuclease VII activity
C4N16_RS03925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4N16_RS03930	COG1506	peptidase
C4N16_RS03930	COG0823	Involved in the tonB-independent uptake of proteins
C4N16_RS03930	COG4946	Tricorn protease homolog
C4N16_RS03935	COG1902	pentaerythritol trinitrate reductase activity
C4N16_RS03940	COG1187	pseudouridine synthase activity
C4N16_RS03955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4N16_RS03960	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C4N16_RS03965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4N16_RS03970	COG0228	four-way junction DNA binding
C4N16_RS04005	COG1203	CRISPR-associated helicase, Cas3
C4N16_RS04015	COG1518	maintenance of DNA repeat elements
C4N16_RS04020	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4N16_RS04030	COG0018	arginyl-trna synthetase
C4N16_RS04035	COG2183	response to ionizing radiation
C4N16_RS04040	COG5002	protein histidine kinase activity
C4N16_RS04040	COG0784	Response regulator, receiver
C4N16_RS04045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4N16_RS04050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4N16_RS04055	COG0752	glycyl-tRNA synthetase alpha subunit
C4N16_RS04060	COG0751	glycine-tRNA ligase activity
C4N16_RS04065	COG0302	gtp cyclohydrolase
C4N16_RS04070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4N16_RS04070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4N16_RS04075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4N16_RS04090	COG0569	domain protein
C4N16_RS04095	COG4771	TonB-dependent receptor
C4N16_RS04110	COG4106	trans-aconitate 2-methyltransferase activity
C4N16_RS04125	COG0010	Belongs to the arginase family
C4N16_RS04135	COG0248	Ppx GppA phosphatase
C4N16_RS04135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4N16_RS04145	COG1295	ribonuclease BN
C4N16_RS04150	COG0768	penicillin binding
C4N16_RS04155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4N16_RS04160	COG0242	peptide deformylase activity
C4N16_RS04170	COG1494	fructose-1,6-bisphosphatase
C4N16_RS04215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4N16_RS04225	COG2832	Protein of unknown function (DUF454)
C4N16_RS04260	COG0540	Belongs to the ATCase OTCase family
C4N16_RS04265	COG0543	2 iron, 2 sulfur cluster binding
C4N16_RS04270	COG0167	dihydroorotate dehydrogenase activity
C4N16_RS04275	COG0284	orotidine-5'-phosphate decarboxylase activity
C4N16_RS04280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4N16_RS04295	COG1757	Na H antiporter
C4N16_RS04300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4N16_RS04310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N16_RS04310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N16_RS04320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4N16_RS04325	COG0616	signal peptide processing
C4N16_RS04330	COG1164	Oligoendopeptidase f
C4N16_RS04350	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C4N16_RS04375	COG0785	Cytochrome C biogenesis protein
C4N16_RS04380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4N16_RS04385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N16_RS04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N16_RS04390	COG4753	response regulator
C4N16_RS04390	COG2207	Transcriptional regulator
C4N16_RS04395	COG2972	Histidine kinase
C4N16_RS04415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4N16_RS04420	COG1757	Na H antiporter
C4N16_RS04425	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4N16_RS04425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4N16_RS04435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4N16_RS04440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4N16_RS04460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4N16_RS04475	COG0268	Binds directly to 16S ribosomal RNA
C4N16_RS04490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4N16_RS04505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4N16_RS04510	COG0037	tRNA processing
C4N16_RS04515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4N16_RS04520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4N16_RS04530	COG0747	negative chemotaxis
C4N16_RS04535	COG0601	transmembrane transport
C4N16_RS04540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N16_RS04545	COG0444	Belongs to the ABC transporter superfamily
C4N16_RS04550	COG4608	Belongs to the ABC transporter superfamily
C4N16_RS04580	COG0848	biopolymer transport protein
C4N16_RS04590	COG2204	response regulator
C4N16_RS04595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4N16_RS04605	COG0359	binds to the 23S rRNA
C4N16_RS04610	COG0305	Participates in initiation and elongation during chromosome replication
C4N16_RS04615	COG0826	peptidase U32
C4N16_RS04630	COG2966	Psort location CytoplasmicMembrane, score
C4N16_RS04635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4N16_RS04640	COG1960	acyl-CoA dehydrogenase activity
C4N16_RS04645	COG2086	electron transfer activity
C4N16_RS04650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4N16_RS04655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4N16_RS04670	COG1272	protein, Hemolysin III
C4N16_RS04675	COG2217	Heavy metal translocating P-type atpase
C4N16_RS04680	COG0436	Aminotransferase
C4N16_RS04685	COG0534	Mate efflux family protein
C4N16_RS04690	COG1968	undecaprenyl-diphosphatase activity
C4N16_RS04695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4N16_RS04710	COG0653	protein targeting
C4N16_RS04715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4N16_RS04720	COG0482	sulfurtransferase activity
C4N16_RS04725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4N16_RS04735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N16_RS04740	COG1461	Dihydroxyacetone kinase
C4N16_RS04750	COG1058	Belongs to the CinA family
C4N16_RS04750	COG1546	Belongs to the CinA family
C4N16_RS04760	COG0826	peptidase U32
C4N16_RS04765	COG0237	dephospho-CoA kinase activity
C4N16_RS04770	COG2169	Transcriptional regulator
C4N16_RS04775	COG1132	(ABC) transporter
C4N16_RS04780	COG1132	(ABC) transporter
C4N16_RS04785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4N16_RS04810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N16_RS04825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4N16_RS04835	COG3142	Participates in the control of copper homeostasis
C4N16_RS04840	COG1027	Aspartate ammonia-lyase
C4N16_RS04880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4N16_RS04885	COG1982	Orn Lys Arg decarboxylase major
C4N16_RS04890	COG2070	2-Nitropropane dioxygenase
C4N16_RS04895	COG0310	cobalt ion transport
C4N16_RS04910	COG1122	ATPase activity
C4N16_RS04920	COG2267	carboxylic ester hydrolase activity
C4N16_RS04930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4N16_RS04945	COG0534	Mate efflux family protein
C4N16_RS04960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4N16_RS04965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4N16_RS04975	COG0210	DNA helicase
C4N16_RS04985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4N16_RS04990	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4N16_RS05000	COG0511	ligase activity, forming carbon-carbon bonds
C4N16_RS05015	COG0494	nUDIX hydrolase
C4N16_RS05020	COG0542	response to heat
C4N16_RS05035	COG1924	4 iron, 4 sulfur cluster binding
C4N16_RS05050	COG1492	cobalamin metabolic process
C4N16_RS05055	COG1115	amino acid carrier protein
C4N16_RS05065	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4N16_RS05085	COG1047	Peptidyl-prolyl cis-trans
C4N16_RS05090	COG0698	ribose 5-phosphate isomerase
C4N16_RS05095	COG0537	adenosine 5'-monophosphoramidase activity
C4N16_RS05105	COG3033	Beta-eliminating lyase
C4N16_RS05110	COG0733	neurotransmitter:sodium symporter activity
C4N16_RS05115	COG4221	oxidoreductase activity
C4N16_RS05125	COG0776	regulation of translation
C4N16_RS05135	COG1607	acyl-coa hydrolase
C4N16_RS05140	COG3246	L-lysine catabolic process to acetate
C4N16_RS05145	COG0604	alcohol dehydrogenase
C4N16_RS05150	COG1509	lysine 2,3-aminomutase activity
C4N16_RS05160	COG1193	negative regulation of DNA recombination
C4N16_RS05165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4N16_RS05170	COG5012	cobalamin binding
C4N16_RS05205	COG2376	Dihydroxyacetone kinase
C4N16_RS05220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N16_RS05225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4N16_RS05230	COG0579	oxidoreductase
C4N16_RS05235	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4N16_RS05250	COG1802	Transcriptional regulator
C4N16_RS05275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C4N16_RS05285	COG2301	Belongs to the HpcH HpaI aldolase family
C4N16_RS05290	COG3051	citrate lyase alpha subunit
C4N16_RS05315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4N16_RS05340	COG0519	Catalyzes the synthesis of GMP from XMP
C4N16_RS05340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4N16_RS05345	COG0582	viral genome integration into host DNA
C4N16_RS05370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4N16_RS05380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4N16_RS05390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4N16_RS05395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4N16_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
C4N16_RS05405	COG0183	Belongs to the thiolase family
C4N16_RS05415	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4N16_RS05420	COG1979	alcohol dehydrogenase
C4N16_RS05425	COG0670	Belongs to the BI1 family
C4N16_RS05440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4N16_RS05440	COG2755	lipolytic protein G-D-S-L family
C4N16_RS05450	COG1592	Rubrerythrin
C4N16_RS05455	COG0058	SHG alpha-glucan phosphorylase activity
C4N16_RS05460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4N16_RS05465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4N16_RS05470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4N16_RS05475	COG0297	glycogen (starch) synthase activity
C4N16_RS05490	COG1692	metallophosphoesterase
C4N16_RS05495	COG2264	protein methyltransferase activity
C4N16_RS05500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4N16_RS05505	COG1519	Transferase
C4N16_RS05505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4N16_RS05510	COG1519	Transferase
C4N16_RS05510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4N16_RS05515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4N16_RS05540	COG2017	converts alpha-aldose to the beta-anomer
C4N16_RS05545	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N16_RS05550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N16_RS05565	COG0275	rRNA processing
C4N16_RS05575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4N16_RS05595	COG1132	(ABC) transporter
C4N16_RS05600	COG1132	(ABC) transporter
C4N16_RS05605	COG1309	transcriptional regulator
C4N16_RS05610	COG0574	Belongs to the PEP-utilizing enzyme family
C4N16_RS05610	COG3848	Pyruvate phosphate dikinase
C4N16_RS05670	COG1301	dicarboxylic acid transport
C4N16_RS05690	COG0577	efflux transmembrane transporter activity
C4N16_RS05695	COG1136	(ABC) transporter
C4N16_RS05695	COG0577	efflux transmembrane transporter activity
C4N16_RS05700	COG1136	(ABC) transporter
C4N16_RS05720	COG0577	efflux transmembrane transporter activity
C4N16_RS05720	COG1136	(ABC) transporter
C4N16_RS05730	COG4166	transmembrane transport
C4N16_RS05735	COG0672	)-iron permease
C4N16_RS05775	COG3328	transposase activity
C4N16_RS05805	COG1022	Amp-dependent synthetase and ligase
C4N16_RS05815	COG1304	FMN binding
C4N16_RS05840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4N16_RS05845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4N16_RS05850	COG0363	glucosamine-6-phosphate deaminase activity
C4N16_RS05855	COG1737	Transcriptional regulator
C4N16_RS05860	COG1242	4 iron, 4 sulfur cluster binding
C4N16_RS05865	COG0252	asparaginase activity
C4N16_RS05875	COG1217	gtp-binding protein TYPA
C4N16_RS05880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4N16_RS05885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N16_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4N16_RS05920	COG2502	aspartate--ammonia ligase
C4N16_RS05925	COG0765	amino acid transport
C4N16_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N16_RS05950	COG4974	Belongs to the 'phage' integrase family
C4N16_RS05990	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4N16_RS06000	COG0481	GTPase activity
C4N16_RS06020	COG3177	Filamentation induced by cAMP protein fic
C4N16_RS06030	COG3550	peptidyl-serine autophosphorylation
C4N16_RS06040	COG3177	Filamentation induced by cAMP protein fic
C4N16_RS06065	COG0405	Gamma-glutamyltransferase
C4N16_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4N16_RS06080	COG0151	Belongs to the GarS family
C4N16_RS06085	COG0138	bifunctional purine biosynthesis protein purh
C4N16_RS06090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4N16_RS06095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4N16_RS06100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4N16_RS06105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4N16_RS06110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4N16_RS06115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4N16_RS06125	COG1363	Peptidase, m42
C4N16_RS06130	COG0747	negative chemotaxis
C4N16_RS06135	COG0561	phosphatase activity
C4N16_RS06140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4N16_RS06145	COG0733	neurotransmitter:sodium symporter activity
C4N16_RS06150	COG2964	Protein conserved in bacteria
C4N16_RS06160	COG2190	(PTS) system
C4N16_RS06165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4N16_RS06170	COG0592	DNA-directed DNA polymerase activity
C4N16_RS06180	COG0561	phosphatase activity
C4N16_RS06215	COG0534	Mate efflux family protein
C4N16_RS06230	COG1132	(ABC) transporter
C4N16_RS06240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4N16_RS06255	COG1024	Enoyl-CoA hydratase
C4N16_RS06260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4N16_RS06270	COG3022	response to hydroperoxide
C4N16_RS06280	COG1115	amino acid carrier protein
C4N16_RS06285	COG1022	Amp-dependent synthetase and ligase
C4N16_RS06290	COG0745	RESPONSE REGULATOR receiver
C4N16_RS06295	COG0037	tRNA processing
C4N16_RS06300	COG0037	tRNA processing
C4N16_RS06315	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N16_RS06320	COG1288	antiporter activity
C4N16_RS06330	COG3842	ATPase activity
C4N16_RS06345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4N16_RS06360	COG0728	peptidoglycan biosynthetic process
C4N16_RS06365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4N16_RS06370	COG0196	riboflavin kinase activity
C4N16_RS06380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N16_RS06380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N16_RS06385	COG0629	single-stranded DNA binding
C4N16_RS06390	COG2096	Adenosyltransferase
C4N16_RS06395	COG1263	PTS System
C4N16_RS06395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N16_RS06405	COG1640	4-alpha-glucanotransferase
C4N16_RS06420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4N16_RS06425	COG1177	transmembrane transport
C4N16_RS06430	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4N16_RS06435	COG3842	ATPase activity
C4N16_RS06445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N16_RS06450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4N16_RS06455	COG1253	flavin adenine dinucleotide binding
C4N16_RS06470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N16_RS06495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4N16_RS06500	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C4N16_RS06505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4N16_RS06550	COG0572	uridine kinase
C4N16_RS06555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C4N16_RS06565	COG4974	Belongs to the 'phage' integrase family
C4N16_RS06575	COG0732	type I restriction modification DNA specificity domain
C4N16_RS06580	COG0732	type I restriction modification DNA specificity domain
C4N16_RS06585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4N16_RS06590	COG1132	(ABC) transporter
C4N16_RS06595	COG4988	ABC transporter
C4N16_RS06605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4N16_RS06615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4N16_RS06620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4N16_RS06625	COG1132	(ABC) transporter
C4N16_RS06640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4N16_RS06645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4N16_RS06655	COG0210	DNA helicase
C4N16_RS06670	COG1183	phosphatidylcholine synthase activity
C4N16_RS06700	COG2116	formate transmembrane transporter activity
C4N16_RS06715	COG1473	amidohydrolase
C4N16_RS06725	COG1136	(ABC) transporter
C4N16_RS06730	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4N16_RS06735	COG0514	ATP-dependent DNA helicase (RecQ)
C4N16_RS06750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N16_RS06755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4N16_RS06760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4N16_RS06765	COG0482	sulfurtransferase activity
C4N16_RS06775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4N16_RS06780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N16_RS06785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N16_RS06800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4N16_RS06805	COG1937	Protein conserved in bacteria
C4N16_RS06840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N16_RS06850	COG0747	negative chemotaxis
C4N16_RS06860	COG2070	2-Nitropropane dioxygenase
C4N16_RS06865	COG1773	rubredoxin
C4N16_RS06865	COG0426	domain, Protein
C4N16_RS06870	COG4807	Protein conserved in bacteria
C4N16_RS06880	COG0006	proline dipeptidase activity
C4N16_RS06885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4N16_RS06890	COG1263	PTS System
C4N16_RS06890	COG2190	(PTS) system
C4N16_RS06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N16_RS06895	COG1199	ATP-dependent helicase activity
C4N16_RS06900	COG1480	7TM receptor with intracellular HD hydrolase
C4N16_RS06905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4N16_RS06910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4N16_RS06920	COG0747	negative chemotaxis
C4N16_RS06935	COG0577	efflux transmembrane transporter activity
C4N16_RS06940	COG1136	(ABC) transporter
C4N16_RS06960	COG0632	four-way junction helicase activity
C4N16_RS06970	COG2385	sporulation resulting in formation of a cellular spore
C4N16_RS06975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4N16_RS06985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4N16_RS07000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4N16_RS07000	COG1116	anion transmembrane transporter activity
C4N16_RS07015	COG0617	tRNA 3'-terminal CCA addition
C4N16_RS07020	COG0494	nUDIX hydrolase
C4N16_RS07025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4N16_RS07030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4N16_RS07035	COG0124	histidyl-tRNA synthetase
C4N16_RS07040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4N16_RS07050	COG1194	a g-specific adenine glycosylase
C4N16_RS07055	COG1739	Uncharacterized protein family UPF0029
C4N16_RS07060	COG0658	competence protein
C4N16_RS07060	COG2333	competence protein COMEC
C4N16_RS07070	COG1323	Belongs to the UPF0348 family
C4N16_RS07080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4N16_RS07090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4N16_RS07095	COG0492	ferredoxin-NADP+ reductase activity
C4N16_RS07100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4N16_RS07120	COG0148	phosphopyruvate hydratase activity
C4N16_RS07135	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4N16_RS07140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N16_RS07150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N16_RS07150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4N16_RS07160	COG1609	Transcriptional regulator
C4N16_RS07175	COG1686	Belongs to the peptidase S11 family
C4N16_RS07180	COG0822	iron-sulfur transferase activity
C4N16_RS07185	COG1104	cysteine desulfurase activity
C4N16_RS07190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4N16_RS07200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4N16_RS07210	COG4771	TonB-dependent receptor
C4N16_RS07225	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C4N16_RS07230	COG0574	Belongs to the PEP-utilizing enzyme family
C4N16_RS07230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4N16_RS07235	COG0517	IMP dehydrogenase activity
C4N16_RS07270	COG1363	Peptidase, m42
C4N16_RS07275	COG0747	negative chemotaxis
C4N16_RS07285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4N16_RS07300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4N16_RS07305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4N16_RS07310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4N16_RS07310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4N16_RS07320	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C4N16_RS07325	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C4N16_RS07330	COG1924	4 iron, 4 sulfur cluster binding
C4N16_RS07335	COG0786	glutamate:sodium symporter activity
C4N16_RS07340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4N16_RS07345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4N16_RS07350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4N16_RS07355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C4N16_RS07370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N16_RS07370	COG3711	transcriptional antiterminator
C4N16_RS07380	COG0786	glutamate:sodium symporter activity
C4N16_RS07385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N16_RS07400	COG3586	endonuclease activity
C4N16_RS07425	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4N16_RS07435	COG0708	Exodeoxyribonuclease III
C4N16_RS07440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4N16_RS07450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4N16_RS07465	COG1362	aminopeptidase activity
C4N16_RS07475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4N16_RS07480	COG0583	DNA-binding transcription factor activity
C4N16_RS07485	COG0525	valine-tRNA ligase activity
C4N16_RS07490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4N16_RS07495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4N16_RS07500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4N16_RS07505	COG0740	serine-type endopeptidase activity
C4N16_RS07510	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4N16_RS07515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4N16_RS07515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4N16_RS07520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4N16_RS07525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4N16_RS07535	COG0195	Participates in both transcription termination and antitermination
C4N16_RS07540	COG0779	Required for maturation of 30S ribosomal subunits
C4N16_RS07545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4N16_RS07560	COG4145	pantothenate transmembrane transporter activity
C4N16_RS07570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4N16_RS07575	COG4172	Belongs to the ABC transporter superfamily
C4N16_RS07580	COG0444	Belongs to the ABC transporter superfamily
C4N16_RS07585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N16_RS07595	COG0747	negative chemotaxis
C4N16_RS07615	COG4750	Nucleotidyl transferase
C4N16_RS07630	COG1088	dTDP-glucose 4,6-dehydratase activity
C4N16_RS07650	COG0110	maltose O-acetyltransferase activity
C4N16_RS07655	COG3475	LICD family
C4N16_RS07665	COG1216	Glycosyl transferase, family 2
C4N16_RS07675	COG0438	transferase activity, transferring glycosyl groups
C4N16_RS07685	COG0859	PFAM glycosyl transferase family 9
C4N16_RS07690	COG2194	sulfuric ester hydrolase activity
C4N16_RS07705	COG1362	aminopeptidase activity
C4N16_RS07710	COG0326	Molecular chaperone. Has ATPase activity
C4N16_RS07715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4N16_RS07735	COG0736	holo-[acyl-carrier-protein] synthase activity
C4N16_RS07740	COG0084	hydrolase, TatD family'
C4N16_RS07755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N16_RS07760	COG2805	Type II/IV secretion system protein
C4N16_RS07765	COG0606	chelatase, subunit chli
C4N16_RS07770	COG1971	Probably functions as a manganese efflux pump
C4N16_RS07775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4N16_RS07790	COG1302	Protein conserved in bacteria
C4N16_RS07795	COG0439	Biotin carboxylase
C4N16_RS07815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4N16_RS07820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4N16_RS07835	COG1214	PFAM Peptidase M22, glycoprotease
C4N16_RS07840	COG0802	atpase or kinase
C4N16_RS07845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4N16_RS07845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4N16_RS07875	COG0602	queuosine metabolic process
C4N16_RS07880	COG1328	CTP reductase activity
C4N16_RS07880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4N16_RS07885	COG0191	fructose-bisphosphate aldolase activity
C4N16_RS07895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4N16_RS07905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4N16_RS07915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4N16_RS07925	COG0357	Ribosomal RNA small subunit methyltransferase G
C4N16_RS07930	COG0445	tRNA wobble uridine modification
C4N16_RS07935	COG0569	domain protein
C4N16_RS07940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4N16_RS07945	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N16_RS07950	COG0534	Mate efflux family protein
C4N16_RS07960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4N16_RS07975	COG1757	Na H antiporter
C4N16_RS07985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4N16_RS07990	COG0280	phosphate acetyltransferase
C4N16_RS07995	COG0552	protein localization to endoplasmic reticulum
C4N16_RS08000	COG2081	HI0933 family
C4N16_RS08010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N16_RS08015	COG4974	Belongs to the 'phage' integrase family
C4N16_RS08020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C4N16_RS08025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4N16_RS08030	COG0758	DNA mediated transformation
C4N16_RS08040	COG1570	exodeoxyribonuclease VII activity
C4N16_RS08045	COG0556	nucleotide-excision repair
C4N16_RS08060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4N16_RS08065	COG1774	PSP1 C-terminal conserved region
C4N16_RS08070	COG2003	Belongs to the UPF0758 family
C4N16_RS08075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4N16_RS08080	COG0406	alpha-ribazole phosphatase activity
C4N16_RS08085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4N16_RS08090	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C4N16_RS08100	COG4783	chaperone-mediated protein folding
C4N16_RS08105	COG0720	synthase
C4N16_RS08110	COG0602	queuosine metabolic process
C4N16_RS08120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4N16_RS08125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4N16_RS08135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4N16_RS08135	COG0517	IMP dehydrogenase activity
C4N16_RS08140	COG2610	gluconate transmembrane transporter activity
C4N16_RS08145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4N16_RS08150	COG3395	kinase activity
C4N16_RS08155	COG1349	DNA-binding transcription factor activity
C4N16_RS08170	COG0126	phosphoglycerate kinase activity
C4N16_RS08180	COG0564	pseudouridine synthase activity
C4N16_RS08185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4N16_RS08190	COG0181	hydroxymethylbilane synthase activity
C4N16_RS08200	COG0113	porphobilinogen synthase activity
C4N16_RS08205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4N16_RS08210	COG0251	oxidation-reduction process
C4N16_RS08240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4N16_RS08250	COG0343	queuine tRNA-ribosyltransferase activity
C4N16_RS08255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4N16_RS08260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4N16_RS08275	COG0511	ligase activity, forming carbon-carbon bonds
C4N16_RS08280	COG4492	Belongs to the UPF0735 family
C4N16_RS08285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4N16_RS08290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4N16_RS08295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4N16_RS08300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N16_RS08300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N16_RS08300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N16_RS08305	COG1381	Involved in DNA repair and RecF pathway recombination