locus-tag	class	description
RN97_RS00015	COG0416	fatty acid biosynthetic process
RN97_RS00020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RN97_RS00025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RN97_RS00030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN97_RS00035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RN97_RS00040	COG0571	ribonuclease III activity
RN97_RS00045	COG1242	4 iron, 4 sulfur cluster binding
RN97_RS00050	COG1530	ribonuclease E activity
RN97_RS00060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RN97_RS00065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RN97_RS00070	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RN97_RS00080	COG0534	Mate efflux family protein
RN97_RS00085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RN97_RS00095	COG3023	N-Acetylmuramoyl-L-alanine amidase
RN97_RS00170	COG1160	GTP binding
RN97_RS00190	COG0850	regulation of cytokinetic process
RN97_RS00195	COG2894	cell division
RN97_RS00200	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RN97_RS00215	COG0579	oxidoreductase
RN97_RS00235	COG0785	Cytochrome C biogenesis protein
RN97_RS00240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN97_RS00245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN97_RS00245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN97_RS00255	COG2972	Histidine kinase
RN97_RS00275	COG0511	ligase activity, forming carbon-carbon bonds
RN97_RS00275	COG5016	pyruvate
RN97_RS00280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RN97_RS00285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RN97_RS00290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RN97_RS00295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN97_RS00300	COG0786	glutamate:sodium symporter activity
RN97_RS00305	COG1924	4 iron, 4 sulfur cluster binding
RN97_RS00310	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RN97_RS00315	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RN97_RS00335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RN97_RS00340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RN97_RS00345	COG1285	pathogenesis
RN97_RS00350	COG4221	oxidoreductase activity
RN97_RS00360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN97_RS00365	COG3279	Response regulator of the LytR AlgR family
RN97_RS00370	COG3275	phosphorelay sensor kinase activity
RN97_RS00375	COG1966	Carbon starvation protein
RN97_RS00385	COG1401	restriction endodeoxyribonuclease activity
RN97_RS00395	COG2211	Major facilitator Superfamily
RN97_RS00400	COG2333	competence protein COMEC
RN97_RS00400	COG0658	competence protein
RN97_RS00405	COG0556	nucleotide-excision repair
RN97_RS00410	COG2610	gluconate transmembrane transporter activity
RN97_RS00415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RN97_RS00420	COG3395	kinase activity
RN97_RS00425	COG1349	DNA-binding transcription factor activity
RN97_RS00440	COG1116	anion transmembrane transporter activity
RN97_RS00445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RN97_RS00450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RN97_RS00475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RN97_RS00485	COG0569	domain protein
RN97_RS00490	COG0617	tRNA 3'-terminal CCA addition
RN97_RS00495	COG2217	Heavy metal translocating P-type atpase
RN97_RS00500	COG2217	Heavy metal translocating P-type atpase
RN97_RS00545	COG1288	antiporter activity
RN97_RS00560	COG2217	Heavy metal translocating P-type atpase
RN97_RS00570	COG0640	Transcriptional regulator
RN97_RS00575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RN97_RS00580	COG1882	Formate acetyltransferase
RN97_RS00605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RN97_RS00610	COG0497	DNA recombination
RN97_RS00615	COG4974	Belongs to the 'phage' integrase family
RN97_RS00620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RN97_RS00630	COG1794	racemase activity, acting on amino acids and derivatives
RN97_RS00635	COG0765	amino acid transport
RN97_RS00640	COG4215	(ABC) transporter
RN97_RS00650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN97_RS00660	COG0626	cystathionine gamma-synthase activity
RN97_RS00735	COG0629	single-stranded DNA binding
RN97_RS00775	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RN97_RS00820	COG0720	synthase
RN97_RS00825	COG0602	queuosine metabolic process
RN97_RS00840	COG1783	phage Terminase large subunit
RN97_RS00850	COG2369	cell adhesion
RN97_RS00965	COG4824	toxin secretion phage lysis holin
RN97_RS00980	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN97_RS00990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RN97_RS00995	COG2890	protein-(glutamine-N5) methyltransferase activity
RN97_RS01000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RN97_RS01005	COG0742	ribosomal rna small subunit methyltransferase
RN97_RS01020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RN97_RS01025	COG4589	Belongs to the CDS family
RN97_RS01030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RN97_RS01040	COG0750	zinc metalloprotease
RN97_RS01045	COG2204	response regulator
RN97_RS01055	COG0358	DNA primase activity
RN97_RS01060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN97_RS01065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN97_RS01080	COG4166	transmembrane transport
RN97_RS01085	COG0811	peptide transport
RN97_RS01090	COG0848	biopolymer transport protein
RN97_RS01110	COG4589	Belongs to the CDS family
RN97_RS01115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RN97_RS01120	COG2267	carboxylic ester hydrolase activity
RN97_RS01130	COG0629	single-stranded DNA binding
RN97_RS01135	COG2096	Adenosyltransferase
RN97_RS01145	COG0488	(ABC) transporter
RN97_RS01155	COG0563	adenylate kinase activity
RN97_RS01170	COG0456	acetyltransferase
RN97_RS01190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RN97_RS01200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RN97_RS01205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RN97_RS01210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RN97_RS01215	COG0202	RNA polymerase activity
RN97_RS01220	COG0203	ribosomal protein L17
RN97_RS01225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN97_RS01235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RN97_RS01240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RN97_RS01245	COG1115	amino acid carrier protein
RN97_RS01250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RN97_RS01255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RN97_RS01260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RN97_RS01275	COG0582	viral genome integration into host DNA
RN97_RS01375	COG1192	Involved in chromosome partitioning
RN97_RS01490	COG0740	serine-type endopeptidase activity
RN97_RS01625	COG3588	fructose-bisphosphate aldolase
RN97_RS01630	COG0326	Molecular chaperone. Has ATPase activity
RN97_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN97_RS01660	COG1283	sodium-dependent phosphate transmembrane transporter activity
RN97_RS01670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN97_RS01685	COG2176	DNA-directed DNA polymerase activity
RN97_RS01690	COG4752	Belongs to the RNA methyltransferase TrmD family
RN97_RS01695	COG0336	Belongs to the RNA methyltransferase TrmD family
RN97_RS01700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RN97_RS01705	COG1837	Belongs to the UPF0109 family
RN97_RS01715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RN97_RS01720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RN97_RS01785	COG3959	Transketolase, thiamine diphosphate binding domain
RN97_RS01790	COG3958	Transketolase
RN97_RS01805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RN97_RS01810	COG0124	histidyl-tRNA synthetase
RN97_RS01815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RN97_RS01825	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RN97_RS01840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN97_RS01845	COG1120	ATPase activity
RN97_RS01855	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN97_RS01860	COG3842	ATPase activity
RN97_RS01865	COG1328	CTP reductase activity
RN97_RS01865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN97_RS01870	COG0602	queuosine metabolic process
RN97_RS01875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RN97_RS01875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN97_RS01885	COG0133	tryptophan synthase activity
RN97_RS01890	COG0346	lactoylglutathione lyase activity
RN97_RS01900	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RN97_RS01910	COG4608	Belongs to the ABC transporter superfamily
RN97_RS01915	COG0444	Belongs to the ABC transporter superfamily
RN97_RS01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN97_RS01925	COG0601	transmembrane transport
RN97_RS01955	COG0726	polysaccharide deacetylase
RN97_RS01965	COG0561	phosphatase activity
RN97_RS01975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RN97_RS01980	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN97_RS01985	COG3842	ATPase activity
RN97_RS01990	COG1840	ABC-type Fe3 transport system, periplasmic component
RN97_RS01995	COG1840	ABC-type Fe3 transport system, periplasmic component
RN97_RS02000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN97_RS02000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN97_RS02010	COG0681	Belongs to the peptidase S26 family
RN97_RS02015	COG0456	acetyltransferase
RN97_RS02020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RN97_RS02030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN97_RS02050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN97_RS02055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RN97_RS02060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN97_RS02065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RN97_RS02070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RN97_RS02075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RN97_RS02080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RN97_RS02090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RN97_RS02100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RN97_RS02125	COG1490	D-aminoacyl-tRNA deacylase activity
RN97_RS02130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RN97_RS02135	COG0688	phosphatidylethanolamine metabolic process
RN97_RS02150	COG0116	Belongs to the methyltransferase superfamily
RN97_RS02160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RN97_RS02165	COG2056	Na+-H+ antiporter family
RN97_RS02170	COG3314	Sporulation integral membrane protein YlbJ
RN97_RS02200	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RN97_RS02205	COG0598	Magnesium transport protein CorA
RN97_RS02225	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN97_RS02255	COG0616	signal peptide processing
RN97_RS02260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RN97_RS02270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN97_RS02270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN97_RS02285	COG2885	chlorophyll binding
RN97_RS02310	COG5002	protein histidine kinase activity
RN97_RS02310	COG3850	Histidine kinase
RN97_RS02315	COG1573	uracil-dna glycosylase
RN97_RS02320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RN97_RS02330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RN97_RS02335	COG0647	UMP catabolic process
RN97_RS02340	COG0778	Nitroreductase
RN97_RS02355	COG0672	)-iron permease
RN97_RS02360	COG2252	PERMEase
RN97_RS02365	COG0859	PFAM glycosyl transferase family 9
RN97_RS02375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RN97_RS02380	COG1213	nucleotidyl transferase
RN97_RS02390	COG0726	polysaccharide deacetylase
RN97_RS02395	COG1216	Glycosyl transferase, family 2
RN97_RS02425	COG0517	IMP dehydrogenase activity
RN97_RS02425	COG0516	GMP reductase activity
RN97_RS02445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RN97_RS02450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RN97_RS02455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RN97_RS02460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RN97_RS02460	COG3153	acetyltransferase
RN97_RS02510	COG0443	Heat shock 70 kDa protein
RN97_RS02540	COG2255	four-way junction helicase activity
RN97_RS02550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RN97_RS02555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN97_RS02570	COG0768	penicillin binding
RN97_RS02575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RN97_RS02580	COG1534	Rna-binding protein
RN97_RS02585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RN97_RS02595	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RN97_RS02600	COG0793	Belongs to the peptidase S41A family
RN97_RS02605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RN97_RS02610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN97_RS02615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RN97_RS02645	COG0126	phosphoglycerate kinase activity
RN97_RS02660	COG0564	pseudouridine synthase activity
RN97_RS02665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RN97_RS02670	COG0181	hydroxymethylbilane synthase activity
RN97_RS02675	COG0519	Catalyzes the synthesis of GMP from XMP
RN97_RS02725	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RN97_RS02755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RN97_RS02760	COG1217	gtp-binding protein TYPA
RN97_RS02770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RN97_RS02785	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
RN97_RS02790	COG0427	acetyl-CoA hydrolase
RN97_RS02800	COG0531	amino acid
RN97_RS02805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RN97_RS02810	COG0668	transmembrane transport
RN97_RS02820	COG0592	DNA-directed DNA polymerase activity
RN97_RS02830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN97_RS02865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN97_RS02870	COG1473	amidohydrolase
RN97_RS02880	COG0601	transmembrane transport
RN97_RS02885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN97_RS02890	COG0444	Belongs to the ABC transporter superfamily
RN97_RS02895	COG4608	Belongs to the ABC transporter superfamily
RN97_RS02905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RN97_RS02910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RN97_RS02955	COG1192	Involved in chromosome partitioning
RN97_RS03070	COG0740	serine-type endopeptidase activity
RN97_RS03205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RN97_RS03245	COG1518	maintenance of DNA repeat elements
RN97_RS03250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RN97_RS03255	COG0280	phosphate acetyltransferase
RN97_RS03260	COG2249	NAD(P)H dehydrogenase (quinone) activity
RN97_RS03265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RN97_RS03270	COG0674	pyruvate-flavodoxin oxidoreductase activity
RN97_RS03270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RN97_RS03270	COG1013	pyruvate-flavodoxin oxidoreductase activity
RN97_RS03270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RN97_RS03275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RN97_RS03280	COG4868	Belongs to the UPF0371 family
RN97_RS03285	COG1022	Amp-dependent synthetase and ligase
RN97_RS03290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN97_RS03295	COG2885	chlorophyll binding
RN97_RS03300	COG1704	LemA family
RN97_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
RN97_RS03310	COG1506	peptidase
RN97_RS03310	COG4946	Tricorn protease homolog
RN97_RS03320	COG1196	nuclear chromosome segregation
RN97_RS03335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RN97_RS03340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RN97_RS03350	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RN97_RS03355	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RN97_RS03360	COG3639	organic phosphonate transmembrane transporter activity
RN97_RS03380	COG2116	formate transmembrane transporter activity
RN97_RS03385	COG1242	4 iron, 4 sulfur cluster binding
RN97_RS03390	COG0363	glucosamine-6-phosphate deaminase activity
RN97_RS03415	COG3681	Belongs to the UPF0597 family
RN97_RS03425	COG1074	ATP-dependent DNA helicase activity
RN97_RS03435	COG0534	Mate efflux family protein
RN97_RS03450	COG1295	ribonuclease BN
RN97_RS03455	COG0768	penicillin binding
RN97_RS03460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RN97_RS03465	COG0242	peptide deformylase activity
RN97_RS03475	COG1494	fructose-1,6-bisphosphatase
RN97_RS03480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RN97_RS03485	COG3829	transcription factor binding
RN97_RS03490	COG3804	dihydrodipicolinate reductase
RN97_RS03500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN97_RS03510	COG5012	cobalamin binding
RN97_RS03520	COG4187	Peptidase family M20/M25/M40
RN97_RS03525	COG1115	amino acid carrier protein
RN97_RS03530	COG3457	Alanine racemase
RN97_RS03535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN97_RS03550	COG1940	carbohydrate kinase activity
RN97_RS03560	COG1129	ABC transporter
RN97_RS03565	COG4211	Belongs to the binding-protein-dependent transport system permease family
RN97_RS03575	COG0039	L-malate dehydrogenase activity
RN97_RS03580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RN97_RS03590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RN97_RS03605	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RN97_RS03625	COG1760	l-serine dehydratase
RN97_RS03635	COG0632	four-way junction helicase activity
RN97_RS03645	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RN97_RS03685	COG3872	metal-dependent enzyme
RN97_RS03690	COG2208	phosphoserine phosphatase activity
RN97_RS03695	COG0322	excinuclease ABC activity
RN97_RS03700	COG1660	Displays ATPase and GTPase activities
RN97_RS03705	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN97_RS03715	COG1335	isochorismatase
RN97_RS03740	COG1132	(ABC) transporter
RN97_RS03770	COG0552	protein localization to endoplasmic reticulum
RN97_RS03780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN97_RS03785	COG4974	Belongs to the 'phage' integrase family
RN97_RS03790	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RN97_RS03795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN97_RS03800	COG0758	DNA mediated transformation
RN97_RS03810	COG1570	exodeoxyribonuclease VII activity
RN97_RS03825	COG1473	amidohydrolase
RN97_RS03835	COG4884	unkown
RN97_RS03835	COG3831	ATPase activity
RN97_RS03840	COG1114	Component of the transport system for branched-chain amino acids
RN97_RS03855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN97_RS03895	COG0346	lactoylglutathione lyase activity
RN97_RS03950	COG2996	Protein conserved in bacteria
RN97_RS03970	COG1687	branched-chain amino acid
RN97_RS03975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RN97_RS03980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RN97_RS03995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RN97_RS04010	COG1116	anion transmembrane transporter activity
RN97_RS04055	COG0612	Peptidase, M16
RN97_RS04060	COG0756	dUTP diphosphatase activity
RN97_RS04065	COG0772	Belongs to the SEDS family
RN97_RS04070	COG0564	pseudouridine synthase activity
RN97_RS04075	COG2252	PERMEase
RN97_RS04080	COG0776	regulation of translation
RN97_RS04085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN97_RS04090	COG1024	Enoyl-CoA hydratase
RN97_RS04095	COG1250	3-hydroxyacyl-CoA dehydrogenase
RN97_RS04110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RN97_RS04120	COG0285	dihydrofolate synthase activity
RN97_RS04130	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RN97_RS04135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RN97_RS04180	COG1032	radical SAM domain protein
RN97_RS04185	COG1032	radical SAM domain protein
RN97_RS04190	COG1032	radical SAM domain protein
RN97_RS04225	COG1032	radical SAM domain protein
RN97_RS04245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RN97_RS04250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RN97_RS04255	COG1363	Peptidase, m42
RN97_RS04260	COG0747	negative chemotaxis
RN97_RS04270	COG5522	Integral membrane protein (intg_mem_TP0381)
RN97_RS04285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN97_RS04295	COG1183	phosphatidylcholine synthase activity
RN97_RS04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN97_RS04305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RN97_RS04310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RN97_RS04315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RN97_RS04320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RN97_RS04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RN97_RS04330	COG0138	bifunctional purine biosynthesis protein purh
RN97_RS04340	COG0151	Belongs to the GarS family
RN97_RS04350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RN97_RS04355	COG0406	alpha-ribazole phosphatase activity
RN97_RS04360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RN97_RS04365	COG2003	Belongs to the UPF0758 family
RN97_RS04370	COG1774	PSP1 C-terminal conserved region
RN97_RS04375	COG2890	protein-(glutamine-N5) methyltransferase activity
RN97_RS04380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RN97_RS04395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RN97_RS04400	COG0517	IMP dehydrogenase activity
RN97_RS04400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RN97_RS04405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RN97_RS04415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RN97_RS04420	COG4221	oxidoreductase activity
RN97_RS04435	COG2315	Protein conserved in bacteria
RN97_RS04495	COG1854	S-ribosylhomocysteine lyase activity
RN97_RS04500	COG1164	Oligoendopeptidase f
RN97_RS04505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN97_RS04510	COG0494	nUDIX hydrolase
RN97_RS04515	COG0616	signal peptide processing
RN97_RS04535	COG1054	Belongs to the UPF0176 family
RN97_RS04540	COG0561	phosphatase activity
RN97_RS04545	COG0037	tRNA processing
RN97_RS04550	COG0318	PFAM AMP-dependent synthetase and ligase
RN97_RS04570	COG0058	SHG alpha-glucan phosphorylase activity
RN97_RS04575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RN97_RS04580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN97_RS04585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN97_RS04590	COG0297	glycogen (starch) synthase activity
RN97_RS04600	COG0500	methyltransferase
RN97_RS04705	COG0577	efflux transmembrane transporter activity
RN97_RS04710	COG1136	(ABC) transporter
RN97_RS04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RN97_RS04730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RN97_RS04735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RN97_RS04745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN97_RS04760	COG0776	regulation of translation
RN97_RS04780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RN97_RS04785	COG0406	alpha-ribazole phosphatase activity
RN97_RS04790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RN97_RS04795	COG2385	sporulation resulting in formation of a cellular spore
RN97_RS04805	COG0785	Cytochrome C biogenesis protein
RN97_RS04815	COG0765	amino acid transport
RN97_RS04820	COG1126	abc transporter atp-binding protein
RN97_RS04825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN97_RS04835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RN97_RS04840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN97_RS04840	COG0574	Belongs to the PEP-utilizing enzyme family
RN97_RS04845	COG0517	IMP dehydrogenase activity
RN97_RS04860	COG0786	glutamate:sodium symporter activity
RN97_RS04865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RN97_RS04870	COG2986	histidine ammonia-lyase
RN97_RS04880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN97_RS04890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RN97_RS04895	COG2086	electron transfer activity
RN97_RS04900	COG1960	acyl-CoA dehydrogenase activity
RN97_RS04930	COG0481	GTPase activity
RN97_RS04935	COG2502	aspartate--ammonia ligase
RN97_RS04940	COG1362	aminopeptidase activity
RN97_RS04955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN97_RS04960	COG4604	ABC transporter, ATP-binding protein
RN97_RS04965	COG4139	cobalamin transport
RN97_RS04970	COG4206	TonB-dependent receptor
RN97_RS04975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN97_RS04985	COG1970	mechanosensitive ion channel activity
RN97_RS04990	COG0482	sulfurtransferase activity
RN97_RS05005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RN97_RS05015	COG0424	maF-like protein
RN97_RS05020	COG1077	Cell shape determining protein MreB Mrl
RN97_RS05025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RN97_RS05030	COG1187	pseudouridine synthase activity
RN97_RS05035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN97_RS05040	COG0154	amidase activity
RN97_RS05045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN97_RS05055	COG0252	asparaginase activity
RN97_RS05185	COG1373	ATPase (AAA superfamily
RN97_RS05195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN97_RS05205	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RN97_RS05240	COG3177	Filamentation induced by cAMP protein fic
RN97_RS05245	COG1797	cobyrinic acid a,c-diamide synthase activity
RN97_RS05250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN97_RS05265	COG1492	cobalamin metabolic process
RN97_RS05285	COG2190	(PTS) system
RN97_RS05300	COG0501	Belongs to the peptidase M48B family
RN97_RS05310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RN97_RS05315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RN97_RS05345	COG1214	PFAM Peptidase M22, glycoprotease
RN97_RS05350	COG0802	atpase or kinase
RN97_RS05355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN97_RS05355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RN97_RS05360	COG0494	nUDIX hydrolase
RN97_RS05375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RN97_RS05405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RN97_RS05410	COG1115	amino acid carrier protein
RN97_RS05415	COG1476	TRANSCRIPTIONal
RN97_RS05420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RN97_RS05425	COG1480	7TM receptor with intracellular HD hydrolase
RN97_RS05430	COG1199	ATP-dependent helicase activity
RN97_RS05435	COG4807	Protein conserved in bacteria
RN97_RS05440	COG3421	Type III restriction
RN97_RS05450	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RN97_RS05465	COG1228	amidohydrolase
RN97_RS05475	COG3404	Formiminotransferase-cyclodeaminase
RN97_RS05495	COG0527	aspartate kinase activity
RN97_RS05500	COG0460	homoserine dehydrogenase
RN97_RS05530	COG1032	radical SAM domain protein
RN97_RS05535	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN97_RS05555	COG1323	Belongs to the UPF0348 family
RN97_RS05565	COG0588	phosphoglycerate mutase activity
RN97_RS05575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RN97_RS05580	COG0716	FMN binding
RN97_RS05595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RN97_RS05610	COG1187	pseudouridine synthase activity
RN97_RS05640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RN97_RS05650	COG0728	peptidoglycan biosynthetic process
RN97_RS05655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RN97_RS05660	COG0196	riboflavin kinase activity
RN97_RS05670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN97_RS05670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN97_RS05680	COG1473	amidohydrolase
RN97_RS05685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN97_RS05685	COG4797	methyltransferase
RN97_RS05690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN97_RS05695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN97_RS05700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RN97_RS05705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN97_RS05710	COG1137	ATPase activity
RN97_RS05720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RN97_RS05760	COG4145	pantothenate transmembrane transporter activity
RN97_RS05765	COG1151	hydroxylamine reductase activity
RN97_RS05775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RN97_RS05785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RN97_RS05790	COG1162	GTPase activity
RN97_RS05820	COG0459	protein refolding
RN97_RS05830	COG4120	Belongs to the binding-protein-dependent transport system permease family
RN97_RS05835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RN97_RS05840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN97_RS05845	COG3384	dioxygenase
RN97_RS05850	COG1373	ATPase (AAA superfamily
RN97_RS05865	COG0701	Predicted permease
RN97_RS05880	COG4974	Belongs to the 'phage' integrase family
RN97_RS05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN97_RS05915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN97_RS05920	COG1121	(ABC) transporter
RN97_RS05925	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN97_RS05935	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RN97_RS05955	COG3829	transcription factor binding
RN97_RS05960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RN97_RS05965	COG0534	Mate efflux family protein
RN97_RS05985	COG0010	Belongs to the arginase family
RN97_RS05995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN97_RS06000	COG2011	ABC-type metal ion transport system permease component
RN97_RS06010	COG1132	(ABC) transporter
RN97_RS06015	COG2375	cellular response to nickel ion
RN97_RS06015	COG1132	(ABC) transporter
RN97_RS06020	COG0426	domain, Protein
RN97_RS06035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RN97_RS06045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RN97_RS06050	COG0557	exoribonuclease II activity
RN97_RS06060	COG1713	HD superfamily hydrolase involved in NAD metabolism
RN97_RS06115	COG3210	domain, Protein
RN97_RS06120	COG3210	domain, Protein
RN97_RS06130	COG2831	hemolysin activation secretion protein
RN97_RS06150	COG1132	(ABC) transporter
RN97_RS06155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN97_RS06165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN97_RS06170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RN97_RS06180	COG0210	DNA helicase
RN97_RS06185	COG1473	amidohydrolase
RN97_RS06195	COG5002	protein histidine kinase activity
RN97_RS06205	COG1136	(ABC) transporter
RN97_RS06215	COG4953	penicillin-binding protein 1C
RN97_RS06235	COG0514	ATP-dependent DNA helicase (RecQ)
RN97_RS06245	COG2304	oxidoreductase activity
RN97_RS06250	COG0758	DNA mediated transformation
RN97_RS06255	COG1598	PFAM Uncharacterised protein family UPF0150
RN97_RS06265	COG0482	sulfurtransferase activity
RN97_RS06270	COG1799	cell septum assembly
RN97_RS06275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RN97_RS06280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN97_RS06285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN97_RS06325	COG3451	type IV secretory pathway VirB4
RN97_RS06335	COG4962	Type ii secretion system protein e
RN97_RS06420	COG0582	viral genome integration into host DNA
RN97_RS06445	COG1192	Involved in chromosome partitioning
RN97_RS06500	COG2003	Belongs to the UPF0758 family
RN97_RS06505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN97_RS06560	COG1473	amidohydrolase
RN97_RS06610	COG1337	RAMP superfamily
RN97_RS06620	COG1353	crispr-associated protein
RN97_RS06625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RN97_RS06630	COG2137	regulation of response to DNA damage stimulus
RN97_RS06635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RN97_RS06640	COG0859	PFAM glycosyl transferase family 9
RN97_RS06650	COG0859	PFAM glycosyl transferase family 9
RN97_RS06660	COG0463	Glycosyl transferase, family 2
RN97_RS06665	COG0726	polysaccharide deacetylase
RN97_RS06670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RN97_RS06675	COG1648	precorrin-2 dehydrogenase activity
RN97_RS06675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RN97_RS06685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RN97_RS06705	COG2855	membrane
RN97_RS06715	COG1278	Cold shock
RN97_RS06725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN97_RS06730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RN97_RS06735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN97_RS06740	COG0210	DNA helicase
RN97_RS06750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN97_RS06755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RN97_RS06780	COG0426	domain, Protein
RN97_RS06785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN97_RS06790	COG4667	esterase of the alpha-beta hydrolase superfamily
RN97_RS06795	COG0018	arginyl-trna synthetase
RN97_RS06800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN97_RS06810	COG0583	DNA-binding transcription factor activity
RN97_RS06815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RN97_RS06820	COG1982	Orn Lys Arg decarboxylase major
RN97_RS06825	COG3033	Beta-eliminating lyase
RN97_RS06830	COG2342	PFAM TM1410 hypothetical-related protein
RN97_RS06845	COG0183	Belongs to the thiolase family
RN97_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
RN97_RS06875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN97_RS06885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RN97_RS06895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN97_RS06905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RN97_RS06910	COG0254	rRNA binding
RN97_RS06930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RN97_RS06935	COG0739	heme binding
RN97_RS06940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RN97_RS06945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN97_RS06955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RN97_RS06965	COG1346	cytolysis
RN97_RS06975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RN97_RS06990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RN97_RS06995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RN97_RS07000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RN97_RS07005	COG0113	porphobilinogen synthase activity
RN97_RS07030	COG1592	Rubrerythrin
RN97_RS07045	COG0006	proline dipeptidase activity
RN97_RS07050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RN97_RS07165	COG2003	Belongs to the UPF0758 family
RN97_RS07265	COG4962	Type ii secretion system protein e
RN97_RS07275	COG3451	type IV secretory pathway VirB4
RN97_RS07300	COG0582	viral genome integration into host DNA
RN97_RS07320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RN97_RS07325	COG1914	H( )-stimulated, divalent metal cation uptake system
RN97_RS07330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN97_RS07335	COG1984	allophanate hydrolase subunit 2
RN97_RS07345	COG0813	purine-nucleoside phosphorylase activity
RN97_RS07350	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN97_RS07375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RN97_RS07380	COG0335	large ribosomal subunit rRNA binding
RN97_RS07390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RN97_RS07395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RN97_RS07400	COG0284	orotidine-5'-phosphate decarboxylase activity
RN97_RS07415	COG0167	dihydroorotate dehydrogenase activity
RN97_RS07420	COG0543	2 iron, 2 sulfur cluster binding
RN97_RS07425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RN97_RS07430	COG0505	Belongs to the CarA family
RN97_RS07435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RN97_RS07440	COG0540	Belongs to the ATCase OTCase family
RN97_RS07445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RN97_RS07515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RN97_RS07520	COG2926	Belongs to the UPF0265 family
RN97_RS07525	COG0205	6-phosphofructokinase activity
RN97_RS07530	COG0825	malonyl-CoA metabolic process
RN97_RS07535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RN97_RS07545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN97_RS07560	COG0180	Tryptophanyl-tRNA synthetase
RN97_RS07565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RN97_RS07585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RN97_RS07590	COG0736	holo-[acyl-carrier-protein] synthase activity
RN97_RS07595	COG0084	hydrolase, TatD family'
RN97_RS07620	COG1136	(ABC) transporter
RN97_RS07640	COG1136	(ABC) transporter
RN97_RS07645	COG1136	(ABC) transporter
RN97_RS07645	COG0577	efflux transmembrane transporter activity
RN97_RS07650	COG0577	efflux transmembrane transporter activity
RN97_RS07665	COG0747	negative chemotaxis
RN97_RS07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN97_RS07680	COG0444	Belongs to the ABC transporter superfamily
RN97_RS07685	COG4608	Belongs to the ABC transporter superfamily
RN97_RS07695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RN97_RS07705	COG0149	triose-phosphate isomerase activity
RN97_RS07715	COG1040	competence protein
RN97_RS07725	COG0792	nuclease activity
RN97_RS07730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN97_RS07735	COG0564	pseudouridine synthase activity
RN97_RS07740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN97_RS07765	COG3052	prosthetic group binding
RN97_RS07780	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RN97_RS07785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RN97_RS07790	COG0714	Associated with various cellular activities
RN97_RS07875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RN97_RS07880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RN97_RS07910	COG0228	four-way junction DNA binding
RN97_RS07915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RN97_RS07920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RN97_RS07930	COG2066	Belongs to the glutaminase family
RN97_RS07935	COG1115	amino acid carrier protein
RN97_RS07940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RN97_RS07965	COG0426	domain, Protein
RN97_RS07970	COG1960	acyl-CoA dehydrogenase activity
RN97_RS07980	COG0384	phenazine biosynthesis protein PhzF
RN97_RS08010	COG4221	oxidoreductase activity
RN97_RS08020	COG1132	(ABC) transporter
RN97_RS08025	COG1132	(ABC) transporter
RN97_RS08030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RN97_RS08035	COG1349	DNA-binding transcription factor activity
RN97_RS08040	COG1105	Belongs to the carbohydrate kinase PfkB family
RN97_RS08045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN97_RS08045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN97_RS08045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN97_RS08050	COG0519	Catalyzes the synthesis of GMP from XMP
RN97_RS08050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RN97_RS08075	COG2985	domain, Protein
RN97_RS08075	COG0569	domain protein
RN97_RS08095	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN97_RS08100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RN97_RS08105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RN97_RS08110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN97_RS08115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN97_RS08120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN97_RS08125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RN97_RS08130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN97_RS08135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RN97_RS08150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RN97_RS08155	COG0789	Transcriptional regulator
RN97_RS08230	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RN97_RS08240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RN97_RS08245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RN97_RS08245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RN97_RS08255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RN97_RS08260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RN97_RS08275	COG2239	Acts as a magnesium transporter
RN97_RS08280	COG0343	queuine tRNA-ribosyltransferase activity
RN97_RS08285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RN97_RS08290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN97_RS08305	COG1253	flavin adenine dinucleotide binding
RN97_RS08310	COG4492	Belongs to the UPF0735 family
RN97_RS08315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RN97_RS08320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RN97_RS08325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN97_RS08330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN97_RS08330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN97_RS08330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN97_RS08335	COG1381	Involved in DNA repair and RecF pathway recombination
RN97_RS08350	COG2814	Major facilitator Superfamily
RN97_RS08360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RN97_RS08365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN97_RS08365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN97_RS08375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN97_RS08375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN97_RS08385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN97_RS08390	COG1045	serine acetyltransferase
RN97_RS08395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RN97_RS08430	COG0495	leucyl-tRNA aminoacylation
RN97_RS08435	COG1595	DNA-templated transcription, initiation
RN97_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN97_RS08445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN97_RS08450	COG0601	transmembrane transport
RN97_RS08455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN97_RS08460	COG0747	negative chemotaxis
RN97_RS08465	COG0444	Belongs to the ABC transporter superfamily
RN97_RS08470	COG4608	Belongs to the ABC transporter superfamily
RN97_RS08480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN97_RS08485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN97_RS08485	COG1263	PTS System
RN97_RS08515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RN97_RS08520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN97_RS08525	COG0049	tRNA binding
RN97_RS08530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RN97_RS08540	COG1454	alcohol dehydrogenase
RN97_RS08545	COG3263	regulation of cellular component size
RN97_RS08555	COG1496	oxidoreductase activity
RN97_RS08560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RN97_RS08625	COG2827	Endonuclease containing a URI domain
RN97_RS08630	COG0470	DNA polymerase III
RN97_RS08635	COG1077	Cell shape determining protein MreB Mrl
RN97_RS08640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RN97_RS08645	COG0215	cysteine-tRNA ligase activity
RN97_RS08650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RN97_RS08655	COG1193	negative regulation of DNA recombination
RN97_RS08685	COG4948	Mandelate Racemase Muconate Lactonizing
RN97_RS08700	COG1245	4Fe-4S binding domain
RN97_RS08700	COG2878	Part of a membrane complex involved in electron transport
RN97_RS08705	COG4657	Part of a membrane complex involved in electron transport
RN97_RS08710	COG4660	Part of a membrane complex involved in electron transport
RN97_RS08715	COG4659	FMN binding
RN97_RS08720	COG4658	electron transport chain
RN97_RS08725	COG4656	Part of a membrane complex involved in electron transport
RN97_RS08730	COG0193	aminoacyl-tRNA hydrolase activity
RN97_RS08760	COG0101	tRNA pseudouridine synthase activity
RN97_RS08770	COG4115	mRNA cleavage
RN97_RS08780	COG0584	glycerophosphoryl diester phosphodiesterase
RN97_RS08785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN97_RS08795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RN97_RS08805	COG1418	mRNA catabolic process
RN97_RS08815	COG2172	sigma factor antagonist activity
RN97_RS08825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RN97_RS08830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RN97_RS08835	COG2226	methyltransferase
RN97_RS08840	COG0482	sulfurtransferase activity
RN97_RS08845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RN97_RS08845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RN97_RS08850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN97_RS08855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN97_RS08860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN97_RS08860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN97_RS08860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN97_RS08865	COG1461	Dihydroxyacetone kinase
RN97_RS08875	COG1058	Belongs to the CinA family
RN97_RS08875	COG1546	Belongs to the CinA family
RN97_RS08880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RN97_RS08885	COG0826	peptidase U32
RN97_RS08890	COG0237	dephospho-CoA kinase activity
RN97_RS08900	COG0542	response to heat
RN97_RS08920	COG2964	Protein conserved in bacteria
RN97_RS08930	COG0733	neurotransmitter:sodium symporter activity
RN97_RS08955	COG0006	proline dipeptidase activity
RN97_RS08960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RN97_RS09065	COG1120	ATPase activity
RN97_RS09070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN97_RS09080	COG4206	TonB-dependent receptor
RN97_RS09090	COG0148	phosphopyruvate hydratase activity
RN97_RS09100	COG0469	pyruvate kinase activity
RN97_RS09180	COG1185	polyribonucleotide nucleotidyltransferase activity
RN97_RS09180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RN97_RS09180	COG0539	negative regulation of cytoplasmic translation
RN97_RS09190	COG4820	ethanolamine utilization protein (EutJ)
RN97_RS09225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RN97_RS09225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN97_RS09230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RN97_RS09235	COG0534	Mate efflux family protein
RN97_RS09245	COG1051	belongs to the nudix hydrolase family
RN97_RS09255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN97_RS09260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN97_RS09270	COG3842	ATPase activity
RN97_RS09275	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN97_RS09280	COG1177	transmembrane transport
RN97_RS09295	COG0786	glutamate:sodium symporter activity
RN97_RS09300	COG1309	transcriptional regulator
RN97_RS09305	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN97_RS09340	COG1121	(ABC) transporter
RN97_RS09350	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN97_RS09370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RN97_RS09375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RN97_RS09405	COG0731	radical SAM domain protein
RN97_RS09405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RN97_RS09435	COG0484	heat shock protein binding
RN97_RS09440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RN97_RS09445	COG0443	Heat shock 70 kDa protein
RN97_RS09455	COG1420	regulation of RNA biosynthetic process
RN97_RS09465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RN97_RS09475	COG1619	proteins homologs of microcin C7 resistance protein MccF
RN97_RS09480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN97_RS09505	COG1598	PFAM Uncharacterised protein family UPF0150
RN97_RS09510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN97_RS09515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN97_RS09525	COG2871	sodium ion transport
RN97_RS09530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RN97_RS09545	COG1268	BioY protein
RN97_RS09550	COG1122	ATPase activity
RN97_RS09555	COG1122	ATPase activity
RN97_RS09560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RN97_RS09570	COG1125	glycine betaine transport
RN97_RS09575	COG1174	glycine betaine transport
RN97_RS09585	COG0525	valine-tRNA ligase activity
RN97_RS09610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RN97_RS09615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RN97_RS09620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RN97_RS09625	COG0740	serine-type endopeptidase activity
RN97_RS09630	COG0544	peptidyl-prolyl cis-trans isomerase activity
RN97_RS09635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN97_RS09635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN97_RS09640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RN97_RS09645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RN97_RS09655	COG0195	Participates in both transcription termination and antitermination
RN97_RS09660	COG0779	Required for maturation of 30S ribosomal subunits
RN97_RS09695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RN97_RS09700	COG1477	protein flavinylation
RN97_RS09710	COG0194	GDP metabolic process
RN97_RS09715	COG1561	YicC-like family, N-terminal region
RN97_RS09720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RN97_RS09725	COG0085	RNA polymerase activity
RN97_RS09730	COG0222	ribosome binding
RN97_RS09735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RN97_RS09740	COG0081	regulation of translation
RN97_RS09745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RN97_RS09750	COG0250	Participates in transcription elongation, termination and antitermination
RN97_RS09765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RN97_RS09775	COG0735	belongs to the Fur family
RN97_RS09830	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RN97_RS09835	COG0166	Belongs to the GPI family
RN97_RS09880	COG1450	Type ii and iii secretion system protein
RN97_RS09920	COG1459	type II secretion system
RN97_RS09925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RN97_RS09955	COG2832	Protein of unknown function (DUF454)
RN97_RS09965	COG0697	spore germination
RN97_RS09970	COG0488	(ABC) transporter
RN97_RS09975	COG3181	Tripartite tricarboxylate transporter family receptor
RN97_RS09995	COG1288	antiporter activity
RN97_RS10000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RN97_RS10005	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
RN97_RS10010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN97_RS10015	COG1115	amino acid carrier protein
RN97_RS10030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN97_RS10030	COG0072	phenylalanine-tRNA ligase activity
RN97_RS10035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RN97_RS10045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RN97_RS10050	COG0187	DNA topoisomerase II activity
RN97_RS10060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN97_RS10080	COG0594	ribonuclease P activity
RN97_RS10085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RN97_RS10090	COG0706	membrane insertase activity
RN97_RS10095	COG1847	R3H domain protein
RN97_RS10100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RN97_RS10105	COG0445	tRNA wobble uridine modification
RN97_RS10110	COG0697	spore germination
RN97_RS10115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RN97_RS10125	COG0157	Belongs to the NadC ModD family
RN97_RS10130	COG1827	regulation of RNA biosynthetic process
RN97_RS10135	COG3077	Addiction module antitoxin, RelB DinJ family
RN97_RS10140	COG0563	adenylate kinase activity
RN97_RS10175	COG2801	Transposase and inactivated derivatives
RN97_RS10190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RN97_RS10195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RN97_RS10200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RN97_RS10205	COG2088	sporulation resulting in formation of a cellular spore
RN97_RS10210	COG1288	antiporter activity
RN97_RS10290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RN97_RS10295	COG1119	ATPase activity
RN97_RS10300	COG0473	3-isopropylmalate dehydrogenase activity
RN97_RS10305	COG0066	3-isopropylmalate dehydratase activity
RN97_RS10315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RN97_RS10320	COG0440	acetolactate synthase activity
RN97_RS10325	COG0028	Belongs to the TPP enzyme family
RN97_RS10330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RN97_RS10335	COG0129	dihydroxy-acid dehydratase activity
RN97_RS10340	COG3177	Filamentation induced by cAMP protein fic
RN97_RS10375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RN97_RS10380	COG0017	Asparaginyl-tRNA synthetase
RN97_RS10390	COG0772	Belongs to the SEDS family
RN97_RS10405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RN97_RS10410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RN97_RS10415	COG0708	Exodeoxyribonuclease III
RN97_RS10430	COG2801	Transposase and inactivated derivatives
RN97_RS10435	COG0647	UMP catabolic process
RN97_RS10445	COG1053	succinate dehydrogenase
RN97_RS10450	COG1393	Belongs to the ArsC family
RN97_RS10455	COG1114	Component of the transport system for branched-chain amino acids
RN97_RS10460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RN97_RS10485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RN97_RS10495	COG4120	Belongs to the binding-protein-dependent transport system permease family
RN97_RS10500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN97_RS10515	COG1757	Na H antiporter
RN97_RS10520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN97_RS10535	COG1492	cobalamin metabolic process
RN97_RS10540	COG1115	amino acid carrier protein
RN97_RS10545	COG1078	dGTPase activity
RN97_RS10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN97_RS10560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RN97_RS10565	COG1104	cysteine desulfurase activity
RN97_RS10570	COG0822	iron-sulfur transferase activity
RN97_RS10580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RN97_RS10605	COG2226	methyltransferase
RN97_RS10640	COG2183	response to ionizing radiation
RN97_RS10645	COG2205	protein histidine kinase activity
RN97_RS10650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RN97_RS10655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RN97_RS10660	COG0752	glycyl-tRNA synthetase alpha subunit
RN97_RS10665	COG0751	glycine-tRNA ligase activity
RN97_RS10670	COG0302	gtp cyclohydrolase
RN97_RS10675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RN97_RS10675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RN97_RS10680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RN97_RS10690	COG0481	GTPase activity
RN97_RS10710	COG4303	Ethanolamine ammonia lyase large subunit
RN97_RS10715	COG4302	ethanolamine ammonia-lyase activity
RN97_RS10720	COG4816	utilization protein
RN97_RS10725	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RN97_RS10735	COG1012	belongs to the aldehyde dehydrogenase family
RN97_RS10735	COG1454	alcohol dehydrogenase
RN97_RS10760	COG3192	ethanolamine utilization protein
RN97_RS10785	COG3118	belongs to the thioredoxin family
RN97_RS10810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RN97_RS10825	COG0009	L-threonylcarbamoyladenylate synthase
RN97_RS10830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RN97_RS10835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RN97_RS10845	COG0733	neurotransmitter:sodium symporter activity
RN97_RS10850	COG3033	Beta-eliminating lyase
RN97_RS10855	COG1802	Transcriptional regulator
RN97_RS10865	COG4452	Inner membrane protein CreD
RN97_RS10875	COG0450	alkyl hydroperoxide reductase
RN97_RS10885	COG1288	antiporter activity
RN97_RS10900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RN97_RS10905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN97_RS10910	COG0037	tRNA processing
RN97_RS10915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RN97_RS10920	COG0513	Belongs to the DEAD box helicase family
RN97_RS10925	COG3177	Filamentation induced by cAMP protein fic
RN97_RS10950	COG0251	oxidation-reduction process
RN97_RS10960	COG3022	response to hydroperoxide
RN97_RS11000	COG0352	thiamine-phosphate diphosphorylase activity
RN97_RS11005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RN97_RS11015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RN97_RS11020	COG2022	thiamine diphosphate biosynthetic process
RN97_RS11030	COG0352	thiamine-phosphate diphosphorylase activity
RN97_RS11040	COG1269	ATP hydrolysis coupled proton transport
RN97_RS11045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN97_RS11050	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
RN97_RS11055	COG1527	subunit (C
RN97_RS11060	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
RN97_RS11070	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
RN97_RS11075	COG1394	ATPase activity, coupled to movement of substances
RN97_RS11095	COG1394	ATPase activity, coupled to movement of substances
RN97_RS11105	COG0512	Glutamine amidotransferase of anthranilate synthase
RN97_RS11115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RN97_RS11120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RN97_RS11130	COG0534	Mate efflux family protein
RN97_RS11135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN97_RS11140	COG0569	domain protein
RN97_RS11145	COG0445	tRNA wobble uridine modification
RN97_RS11150	COG0357	Ribosomal RNA small subunit methyltransferase G
RN97_RS11170	COG0653	protein targeting
RN97_RS11175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RN97_RS11205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RN97_RS11215	COG0275	rRNA processing
RN97_RS11230	COG1185	polyribonucleotide nucleotidyltransferase activity
RN97_RS11240	COG0730	response to heat
RN97_RS11245	COG1752	Esterase of the alpha-beta hydrolase superfamily
RN97_RS11250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN97_RS11255	COG1968	undecaprenyl-diphosphatase activity
RN97_RS11265	COG1091	dTDP-4-dehydrorhamnose reductase activity
RN97_RS11275	COG1086	Polysaccharide biosynthesis protein
RN97_RS11280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RN97_RS11285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RN97_RS11300	COG1086	Polysaccharide biosynthesis protein
RN97_RS11325	COG0728	peptidoglycan biosynthetic process
RN97_RS11330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RN97_RS11330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN97_RS11350	COG1088	dTDP-glucose 4,6-dehydratase activity
RN97_RS11380	COG0217	transcriptional regulatory protein
RN97_RS11385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RN97_RS11390	COG0442	prolyl-tRNA aminoacylation
RN97_RS11395	COG0360	Binds together with S18 to 16S ribosomal RNA
RN97_RS11400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RN97_RS11405	COG0501	Belongs to the peptidase M48B family
RN97_RS11415	COG0534	Mate efflux family protein
RN97_RS11420	COG0051	transcription antitermination factor activity, RNA binding
RN97_RS11425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RN97_RS11430	COG0088	Forms part of the polypeptide exit tunnel
RN97_RS11435	COG0089	rRNA binding
RN97_RS11440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RN97_RS11445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RN97_RS11450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RN97_RS11455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RN97_RS11460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RN97_RS11465	COG0255	Belongs to the universal ribosomal protein uL29 family
RN97_RS11470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RN97_RS11475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RN97_RS11485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RN97_RS11490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RN97_RS11495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RN97_RS11500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RN97_RS11505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RN97_RS11510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RN97_RS11515	COG1841	ribosomal large subunit assembly
RN97_RS11520	COG0200	Binds to the 23S rRNA
RN97_RS11530	COG0233	cytoplasmic translational termination
RN97_RS11535	COG0528	UMP kinase activity
RN97_RS11540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RN97_RS11545	COG0052	Belongs to the universal ribosomal protein uS2 family
RN97_RS11565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN97_RS11570	COG1971	Probably functions as a manganese efflux pump
RN97_RS11575	COG0606	chelatase, subunit chli
RN97_RS11655	COG0606	chelatase, subunit chli
RN97_RS11660	COG2805	Type II/IV secretion system protein
RN97_RS11665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN97_RS11675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RN97_RS11690	COG1692	metallophosphoesterase
RN97_RS11695	COG2264	protein methyltransferase activity
RN97_RS11700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RN97_RS11705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RN97_RS11705	COG1519	Transferase
RN97_RS11710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RN97_RS11720	COG1683	Conserved Protein
RN97_RS11735	COG0268	Binds directly to 16S ribosomal RNA
RN97_RS11750	COG1739	Uncharacterized protein family UPF0029
RN97_RS11755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RN97_RS11765	COG1733	regulation of RNA biosynthetic process
RN97_RS11770	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN97_RS11795	COG1129	ABC transporter
RN97_RS11815	COG2992	FlgJ-related protein
RN97_RS11820	COG0584	glycerophosphoryl diester phosphodiesterase
RN97_RS11850	COG0268	Binds directly to 16S ribosomal RNA
RN97_RS11875	COG0698	ribose 5-phosphate isomerase
RN97_RS11880	COG0537	adenosine 5'-monophosphoramidase activity
RN97_RS11900	COG1607	acyl-coa hydrolase
RN97_RS11905	COG3246	L-lysine catabolic process to acetate
RN97_RS11910	COG0604	alcohol dehydrogenase
RN97_RS11915	COG1509	lysine 2,3-aminomutase activity
RN97_RS11925	COG1193	negative regulation of DNA recombination
RN97_RS11930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RN97_RS11935	COG5012	cobalamin binding
RN97_RS11945	COG1757	Na H antiporter
RN97_RS11955	COG2031	fatty acid transporter
RN97_RS11960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RN97_RS11970	COG4865	methylaspartate mutase activity
RN97_RS11980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RN97_RS11990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RN97_RS11995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RN97_RS12010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN97_RS12030	COG4221	oxidoreductase activity
RN97_RS12045	COG2376	Dihydroxyacetone kinase
RN97_RS12050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RN97_RS12055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN97_RS12080	COG4869	propanediol catabolic process
RN97_RS12135	COG0745	RESPONSE REGULATOR receiver
RN97_RS12160	COG0811	peptide transport
RN97_RS12165	COG0848	biopolymer transport protein
RN97_RS12180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RN97_RS12190	COG0359	binds to the 23S rRNA
RN97_RS12195	COG0305	Participates in initiation and elongation during chromosome replication
RN97_RS12200	COG0826	peptidase U32
RN97_RS12205	COG2801	Transposase and inactivated derivatives
RN97_RS12235	COG1132	(ABC) transporter
RN97_RS12240	COG4988	ABC transporter
RN97_RS12245	COG2831	hemolysin activation secretion protein
RN97_RS12250	COG3210	domain, Protein
RN97_RS12250	COG3210	domain, Protein
RN97_RS12275	COG2831	hemolysin activation secretion protein
RN97_RS12280	COG3210	domain, Protein
RN97_RS12280	COG3210	domain, Protein