locus-tag	class	description
HMPREF0409_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF0409_RS00025	COG0187	DNA topoisomerase II activity
HMPREF0409_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0409_RS00040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMPREF0409_RS00045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0409_RS00045	COG0072	phenylalanine-tRNA ligase activity
HMPREF0409_RS00065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0409_RS00070	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HMPREF0409_RS00080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF0409_RS00095	COG1288	antiporter activity
HMPREF0409_RS00115	COG0488	(ABC) transporter
HMPREF0409_RS00120	COG0697	spore germination
HMPREF0409_RS00130	COG2832	Protein of unknown function (DUF454)
HMPREF0409_RS00150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPREF0409_RS00155	COG1459	type II secretion system
HMPREF0409_RS00195	COG1450	Type ii and iii secretion system protein
HMPREF0409_RS00210	COG1053	succinate dehydrogenase
HMPREF0409_RS00215	COG1393	Belongs to the ArsC family
HMPREF0409_RS00220	COG1114	Component of the transport system for branched-chain amino acids
HMPREF0409_RS00225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMPREF0409_RS00230	COG1247	-acetyltransferase
HMPREF0409_RS00240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF0409_RS00245	COG1104	cysteine desulfurase activity
HMPREF0409_RS00250	COG0822	iron-sulfur transferase activity
HMPREF0409_RS00260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HMPREF0409_RS00300	COG2183	response to ionizing radiation
HMPREF0409_RS00305	COG2205	protein histidine kinase activity
HMPREF0409_RS00310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF0409_RS00315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF0409_RS00320	COG0752	glycyl-tRNA synthetase alpha subunit
HMPREF0409_RS00325	COG0751	glycine-tRNA ligase activity
HMPREF0409_RS00330	COG0302	gtp cyclohydrolase
HMPREF0409_RS00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF0409_RS00335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF0409_RS00340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF0409_RS00370	COG4303	Ethanolamine ammonia lyase large subunit
HMPREF0409_RS00375	COG4302	ethanolamine ammonia-lyase activity
HMPREF0409_RS00380	COG4816	utilization protein
HMPREF0409_RS00385	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HMPREF0409_RS00395	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0409_RS00395	COG1454	alcohol dehydrogenase
HMPREF0409_RS00420	COG3192	ethanolamine utilization protein
HMPREF0409_RS00445	COG3118	belongs to the thioredoxin family
HMPREF0409_RS00480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF0409_RS00485	COG2871	sodium ion transport
HMPREF0409_RS00495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0409_RS00500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0409_RS00515	COG2378	regulation of single-species biofilm formation
HMPREF0409_RS00525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMPREF0409_RS00535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF0409_RS00560	COG1420	regulation of RNA biosynthetic process
HMPREF0409_RS00565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMPREF0409_RS00570	COG0443	Heat shock 70 kDa protein
HMPREF0409_RS00630	COG0731	radical SAM domain protein
HMPREF0409_RS00630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF0409_RS00640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HMPREF0409_RS00645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HMPREF0409_RS00655	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0409_RS00665	COG1121	(ABC) transporter
HMPREF0409_RS00700	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF0409_RS00705	COG1309	transcriptional regulator
HMPREF0409_RS00710	COG0786	glutamate:sodium symporter activity
HMPREF0409_RS00720	COG1177	transmembrane transport
HMPREF0409_RS00725	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPREF0409_RS00730	COG3842	ATPase activity
HMPREF0409_RS00740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0409_RS00745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0409_RS00755	COG1051	belongs to the nudix hydrolase family
HMPREF0409_RS00765	COG0534	Mate efflux family protein
HMPREF0409_RS00770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HMPREF0409_RS00775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF0409_RS00775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF0409_RS00800	COG4820	ethanolamine utilization protein (EutJ)
HMPREF0409_RS00810	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF0409_RS00810	COG0539	negative regulation of cytoplasmic translation
HMPREF0409_RS00810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMPREF0409_RS00815	COG0539	negative regulation of cytoplasmic translation
HMPREF0409_RS00815	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF0409_RS00815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMPREF0409_RS00895	COG0469	pyruvate kinase activity
HMPREF0409_RS00900	COG0148	phosphopyruvate hydratase activity
HMPREF0409_RS00950	COG1518	maintenance of DNA repeat elements
HMPREF0409_RS00965	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF0409_RS00970	COG1115	amino acid carrier protein
HMPREF0409_RS00975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HMPREF0409_RS00980	COG0006	proline dipeptidase activity
HMPREF0409_RS00985	COG1694	Mazg nucleotide pyrophosphohydrolase
HMPREF0409_RS01005	COG0779	Required for maturation of 30S ribosomal subunits
HMPREF0409_RS01010	COG0195	Participates in both transcription termination and antitermination
HMPREF0409_RS01020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMPREF0409_RS01025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMPREF0409_RS01030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPREF0409_RS01030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF0409_RS01035	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF0409_RS01040	COG0740	serine-type endopeptidase activity
HMPREF0409_RS01045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMPREF0409_RS01050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMPREF0409_RS01055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HMPREF0409_RS01060	COG0525	valine-tRNA ligase activity
HMPREF0409_RS01070	COG1174	glycine betaine transport
HMPREF0409_RS01075	COG1125	glycine betaine transport
HMPREF0409_RS01100	COG0237	dephospho-CoA kinase activity
HMPREF0409_RS01105	COG0826	peptidase U32
HMPREF0409_RS01110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HMPREF0409_RS01115	COG1058	Belongs to the CinA family
HMPREF0409_RS01115	COG1546	Belongs to the CinA family
HMPREF0409_RS01125	COG1461	Dihydroxyacetone kinase
HMPREF0409_RS01130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0409_RS01130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0409_RS01130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0409_RS01135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMPREF0409_RS01155	COG0482	sulfurtransferase activity
HMPREF0409_RS01160	COG2226	methyltransferase
HMPREF0409_RS01170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF0409_RS01175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF0409_RS01195	COG1418	mRNA catabolic process
HMPREF0409_RS01205	COG0653	protein targeting
HMPREF0409_RS01210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF0409_RS01240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0409_RS01250	COG0275	rRNA processing
HMPREF0409_RS01260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF0409_RS01265	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF0409_RS01275	COG0730	response to heat
HMPREF0409_RS01280	COG1752	Esterase of the alpha-beta hydrolase superfamily
HMPREF0409_RS01285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPREF0409_RS01290	COG1968	undecaprenyl-diphosphatase activity
HMPREF0409_RS01300	COG1091	dTDP-4-dehydrorhamnose reductase activity
HMPREF0409_RS01310	COG1086	Polysaccharide biosynthesis protein
HMPREF0409_RS01315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HMPREF0409_RS01325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF0409_RS01345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMPREF0409_RS01355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMPREF0409_RS01360	COG0297	glycogen (starch) synthase activity
HMPREF0409_RS01420	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF0409_RS01440	COG0217	transcriptional regulatory protein
HMPREF0409_RS01445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF0409_RS01450	COG0442	prolyl-tRNA aminoacylation
HMPREF0409_RS01455	COG0360	Binds together with S18 to 16S ribosomal RNA
HMPREF0409_RS01460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF0409_RS01465	COG0501	Belongs to the peptidase M48B family
HMPREF0409_RS01480	COG0233	cytoplasmic translational termination
HMPREF0409_RS01485	COG0528	UMP kinase activity
HMPREF0409_RS01490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF0409_RS01495	COG0052	Belongs to the universal ribosomal protein uS2 family
HMPREF0409_RS01515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0409_RS01520	COG1971	Probably functions as a manganese efflux pump
HMPREF0409_RS01525	COG0606	chelatase, subunit chli
HMPREF0409_RS01530	COG2805	Type II/IV secretion system protein
HMPREF0409_RS01535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF0409_RS01545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMPREF0409_RS01555	COG1692	metallophosphoesterase
HMPREF0409_RS01560	COG2264	protein methyltransferase activity
HMPREF0409_RS01570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HMPREF0409_RS01580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF0409_RS01580	COG1519	Transferase
HMPREF0409_RS01585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMPREF0409_RS01595	COG1683	Conserved Protein
HMPREF0409_RS01600	COG1739	Uncharacterized protein family UPF0029
HMPREF0409_RS01605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMPREF0409_RS01660	COG1129	ABC transporter
HMPREF0409_RS01695	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF0409_RS01725	COG0268	Binds directly to 16S ribosomal RNA
HMPREF0409_RS01735	COG2252	PERMEase
HMPREF0409_RS01750	COG0698	ribose 5-phosphate isomerase
HMPREF0409_RS01755	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF0409_RS01770	COG1607	acyl-coa hydrolase
HMPREF0409_RS01775	COG3246	L-lysine catabolic process to acetate
HMPREF0409_RS01780	COG0604	alcohol dehydrogenase
HMPREF0409_RS01785	COG1509	lysine 2,3-aminomutase activity
HMPREF0409_RS01800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF0409_RS01805	COG5012	cobalamin binding
HMPREF0409_RS01815	COG1757	Na H antiporter
HMPREF0409_RS01825	COG2031	fatty acid transporter
HMPREF0409_RS01830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMPREF0409_RS01840	COG4865	methylaspartate mutase activity
HMPREF0409_RS01850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HMPREF0409_RS01860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMPREF0409_RS01865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF0409_RS01880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPREF0409_RS01910	COG1349	DNA-binding transcription factor activity
HMPREF0409_RS01915	COG3395	kinase activity
HMPREF0409_RS01920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HMPREF0409_RS01925	COG2610	gluconate transmembrane transporter activity
HMPREF0409_RS01940	COG2376	Dihydroxyacetone kinase
HMPREF0409_RS01945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF0409_RS01950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF0409_RS01980	COG4869	propanediol catabolic process
HMPREF0409_RS02035	COG0745	RESPONSE REGULATOR receiver
HMPREF0409_RS02060	COG0811	peptide transport
HMPREF0409_RS02080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF0409_RS02090	COG0359	binds to the 23S rRNA
HMPREF0409_RS02095	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF0409_RS02100	COG0826	peptidase U32
HMPREF0409_RS02135	COG1132	(ABC) transporter
HMPREF0409_RS02140	COG4988	ABC transporter
HMPREF0409_RS02145	COG2831	hemolysin activation secretion protein
HMPREF0409_RS02210	COG0416	fatty acid biosynthetic process
HMPREF0409_RS02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF0409_RS02220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF0409_RS02225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0409_RS02230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMPREF0409_RS02235	COG0571	ribonuclease III activity
HMPREF0409_RS02240	COG1242	4 iron, 4 sulfur cluster binding
HMPREF0409_RS02245	COG1530	ribonuclease E activity
HMPREF0409_RS02250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF0409_RS02255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF0409_RS02260	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMPREF0409_RS02265	COG0534	Mate efflux family protein
HMPREF0409_RS02270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPREF0409_RS02275	COG0646	methionine synthase
HMPREF0409_RS02275	COG1410	methionine synthase
HMPREF0409_RS02280	COG3023	N-Acetylmuramoyl-L-alanine amidase
HMPREF0409_RS02320	COG1160	GTP binding
HMPREF0409_RS02345	COG2894	cell division
HMPREF0409_RS02350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HMPREF0409_RS02380	COG0579	oxidoreductase
HMPREF0409_RS02410	COG0785	Cytochrome C biogenesis protein
HMPREF0409_RS02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0409_RS02420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0409_RS02420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0409_RS02425	COG2197	response regulator
HMPREF0409_RS02440	COG2972	Histidine kinase
HMPREF0409_RS02455	COG0747	negative chemotaxis
HMPREF0409_RS02460	COG0601	transmembrane transport
HMPREF0409_RS02465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS02495	COG5016	pyruvate
HMPREF0409_RS02495	COG0511	ligase activity, forming carbon-carbon bonds
HMPREF0409_RS02500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HMPREF0409_RS02505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMPREF0409_RS02510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HMPREF0409_RS02515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF0409_RS02520	COG0786	glutamate:sodium symporter activity
HMPREF0409_RS02525	COG1924	4 iron, 4 sulfur cluster binding
HMPREF0409_RS02530	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HMPREF0409_RS02535	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HMPREF0409_RS02550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HMPREF0409_RS02555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HMPREF0409_RS02560	COG1285	pathogenesis
HMPREF0409_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0409_RS02575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0409_RS02580	COG3279	Response regulator of the LytR AlgR family
HMPREF0409_RS02585	COG3275	phosphorelay sensor kinase activity
HMPREF0409_RS02590	COG1966	Carbon starvation protein
HMPREF0409_RS02595	COG2211	Major facilitator Superfamily
HMPREF0409_RS02600	COG0658	competence protein
HMPREF0409_RS02600	COG2333	competence protein COMEC
HMPREF0409_RS02605	COG0556	nucleotide-excision repair
HMPREF0409_RS02635	COG0813	purine-nucleoside phosphorylase activity
HMPREF0409_RS02645	COG1328	CTP reductase activity
HMPREF0409_RS02645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0409_RS02650	COG3842	ATPase activity
HMPREF0409_RS02655	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPREF0409_RS02695	COG0601	transmembrane transport
HMPREF0409_RS02700	COG0747	negative chemotaxis
HMPREF0409_RS02705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMPREF0409_RS02710	COG0124	histidyl-tRNA synthetase
HMPREF0409_RS02715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF0409_RS02735	COG3958	Transketolase
HMPREF0409_RS02740	COG3959	Transketolase, thiamine diphosphate binding domain
HMPREF0409_RS02775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF0409_RS02780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF0409_RS02790	COG1837	Belongs to the UPF0109 family
HMPREF0409_RS02795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMPREF0409_RS02800	COG0336	Belongs to the RNA methyltransferase TrmD family
HMPREF0409_RS02805	COG4752	Belongs to the RNA methyltransferase TrmD family
HMPREF0409_RS02825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0409_RS02835	COG1283	sodium-dependent phosphate transmembrane transporter activity
HMPREF0409_RS02840	COG0326	Molecular chaperone. Has ATPase activity
HMPREF0409_RS02845	COG3588	fructose-bisphosphate aldolase
HMPREF0409_RS02860	COG3177	Filamentation induced by cAMP protein fic
HMPREF0409_RS02885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF0409_RS02890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMPREF0409_RS02895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF0409_RS02900	COG1115	amino acid carrier protein
HMPREF0409_RS02905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF0409_RS02910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HMPREF0409_RS02920	COG0598	Magnesium transport protein CorA
HMPREF0409_RS02925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HMPREF0409_RS02965	COG3314	Sporulation integral membrane protein YlbJ
HMPREF0409_RS02975	COG2056	Na+-H+ antiporter family
HMPREF0409_RS02980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF0409_RS02990	COG0116	Belongs to the methyltransferase superfamily
HMPREF0409_RS03005	COG0688	phosphatidylethanolamine metabolic process
HMPREF0409_RS03010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPREF0409_RS03015	COG1490	D-aminoacyl-tRNA deacylase activity
HMPREF0409_RS03050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMPREF0409_RS03060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF0409_RS03065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMPREF0409_RS03070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMPREF0409_RS03075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMPREF0409_RS03080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0409_RS03085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMPREF0409_RS03090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0409_RS03105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0409_RS03115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF0409_RS03120	COG0456	acetyltransferase
HMPREF0409_RS03125	COG0681	Belongs to the peptidase S26 family
HMPREF0409_RS03130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF0409_RS03130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPREF0409_RS03135	COG1840	ABC-type Fe3 transport system, periplasmic component
HMPREF0409_RS03140	COG3842	ATPase activity
HMPREF0409_RS03145	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPREF0409_RS03150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0409_RS03170	COG0438	transferase activity, transferring glycosyl groups
HMPREF0409_RS03185	COG2342	PFAM TM1410 hypothetical-related protein
HMPREF0409_RS03195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMPREF0409_RS03315	COG1783	phage Terminase large subunit
HMPREF0409_RS03455	COG0561	phosphatase activity
HMPREF0409_RS03465	COG0726	polysaccharide deacetylase
HMPREF0409_RS03485	COG0601	transmembrane transport
HMPREF0409_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS03495	COG0444	Belongs to the ABC transporter superfamily
HMPREF0409_RS03500	COG4608	Belongs to the ABC transporter superfamily
HMPREF0409_RS03505	COG4115	mRNA cleavage
HMPREF0409_RS03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF0409_RS03550	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0409_RS03555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMPREF0409_RS03560	COG0742	ribosomal rna small subunit methyltransferase
HMPREF0409_RS03575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0409_RS03580	COG4589	Belongs to the CDS family
HMPREF0409_RS03585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HMPREF0409_RS03595	COG0750	zinc metalloprotease
HMPREF0409_RS03600	COG2204	response regulator
HMPREF0409_RS03610	COG0358	DNA primase activity
HMPREF0409_RS03615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0409_RS03635	COG4166	transmembrane transport
HMPREF0409_RS03645	COG0848	biopolymer transport protein
HMPREF0409_RS03660	COG4589	Belongs to the CDS family
HMPREF0409_RS03665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF0409_RS03670	COG2267	carboxylic ester hydrolase activity
HMPREF0409_RS03680	COG0629	single-stranded DNA binding
HMPREF0409_RS03685	COG2096	Adenosyltransferase
HMPREF0409_RS03695	COG0488	(ABC) transporter
HMPREF0409_RS03705	COG0563	adenylate kinase activity
HMPREF0409_RS03755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF0409_RS03765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMPREF0409_RS03770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF0409_RS03775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMPREF0409_RS03780	COG0202	RNA polymerase activity
HMPREF0409_RS03785	COG0203	ribosomal protein L17
HMPREF0409_RS03820	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF0409_RS03825	COG1102	Psort location Cytoplasmic, score
HMPREF0409_RS03855	COG0616	signal peptide processing
HMPREF0409_RS03860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMPREF0409_RS03870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0409_RS03870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0409_RS03885	COG2885	chlorophyll binding
HMPREF0409_RS03905	COG0463	Glycosyl transferase, family 2
HMPREF0409_RS03910	COG0745	RESPONSE REGULATOR receiver
HMPREF0409_RS03915	COG5002	protein histidine kinase activity
HMPREF0409_RS03915	COG3850	Histidine kinase
HMPREF0409_RS03920	COG1573	uracil-dna glycosylase
HMPREF0409_RS03925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMPREF0409_RS03935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMPREF0409_RS03945	COG0647	UMP catabolic process
HMPREF0409_RS03965	COG0672	)-iron permease
HMPREF0409_RS03970	COG2252	PERMEase
HMPREF0409_RS03980	COG3475	LICD family
HMPREF0409_RS03985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HMPREF0409_RS03990	COG1213	nucleotidyl transferase
HMPREF0409_RS04000	COG0726	polysaccharide deacetylase
HMPREF0409_RS04005	COG1216	Glycosyl transferase, family 2
HMPREF0409_RS04055	COG0517	IMP dehydrogenase activity
HMPREF0409_RS04055	COG0516	GMP reductase activity
HMPREF0409_RS04075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMPREF0409_RS04080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF0409_RS04085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HMPREF0409_RS04110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HMPREF0409_RS04120	COG4399	Belongs to the UPF0754 family
HMPREF0409_RS04125	COG2255	four-way junction helicase activity
HMPREF0409_RS04130	COG1959	2 iron, 2 sulfur cluster binding
HMPREF0409_RS04135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF0409_RS04140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF0409_RS04155	COG0768	penicillin binding
HMPREF0409_RS04160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF0409_RS04165	COG1534	Rna-binding protein
HMPREF0409_RS04170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF0409_RS04180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMPREF0409_RS04185	COG0793	Belongs to the peptidase S41A family
HMPREF0409_RS04185	COG3409	Peptidoglycan-binding domain 1 protein
HMPREF0409_RS04190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMPREF0409_RS04195	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0409_RS04200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HMPREF0409_RS04210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF0409_RS04250	COG4145	pantothenate transmembrane transporter activity
HMPREF0409_RS04285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMPREF0409_RS04290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMPREF0409_RS04300	COG1137	ATPase activity
HMPREF0409_RS04305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF0409_RS04310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMPREF0409_RS04315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF0409_RS04320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF0409_RS04325	COG4797	methyltransferase
HMPREF0409_RS04325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HMPREF0409_RS04330	COG1473	amidohydrolase
HMPREF0409_RS04340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0409_RS04340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0409_RS04350	COG0196	riboflavin kinase activity
HMPREF0409_RS04360	COG0728	peptidoglycan biosynthetic process
HMPREF0409_RS04370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPREF0409_RS04400	COG1187	pseudouridine synthase activity
HMPREF0409_RS04415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMPREF0409_RS04425	COG0716	FMN binding
HMPREF0409_RS04430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HMPREF0409_RS04440	COG3177	Filamentation induced by cAMP protein fic
HMPREF0409_RS04445	COG0588	phosphoglycerate mutase activity
HMPREF0409_RS04455	COG1323	Belongs to the UPF0348 family
HMPREF0409_RS04460	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF0409_RS04465	COG1032	radical SAM domain protein
HMPREF0409_RS04480	COG0460	homoserine dehydrogenase
HMPREF0409_RS04495	COG3404	Formiminotransferase-cyclodeaminase
HMPREF0409_RS04505	COG1228	amidohydrolase
HMPREF0409_RS04515	COG4807	Protein conserved in bacteria
HMPREF0409_RS04520	COG1199	ATP-dependent helicase activity
HMPREF0409_RS04525	COG1480	7TM receptor with intracellular HD hydrolase
HMPREF0409_RS04530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMPREF0409_RS04555	COG0252	asparaginase activity
HMPREF0409_RS04565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF0409_RS04570	COG0154	amidase activity
HMPREF0409_RS04575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF0409_RS04580	COG1187	pseudouridine synthase activity
HMPREF0409_RS04585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF0409_RS04590	COG1077	Cell shape determining protein MreB Mrl
HMPREF0409_RS04595	COG0424	maF-like protein
HMPREF0409_RS04605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HMPREF0409_RS04620	COG0482	sulfurtransferase activity
HMPREF0409_RS04625	COG1970	mechanosensitive ion channel activity
HMPREF0409_RS04630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF0409_RS04635	COG4206	TonB-dependent receptor
HMPREF0409_RS04640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0409_RS04650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF0409_RS04665	COG1362	aminopeptidase activity
HMPREF0409_RS04670	COG2502	aspartate--ammonia ligase
HMPREF0409_RS04675	COG0481	GTPase activity
HMPREF0409_RS04685	COG0523	cobalamin synthesis protein
HMPREF0409_RS04695	COG2966	Psort location CytoplasmicMembrane, score
HMPREF0409_RS04700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPREF0409_RS04705	COG1960	acyl-CoA dehydrogenase activity
HMPREF0409_RS04710	COG2086	electron transfer activity
HMPREF0409_RS04715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HMPREF0409_RS04725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF0409_RS04730	COG1940	carbohydrate kinase activity
HMPREF0409_RS04735	COG2986	histidine ammonia-lyase
HMPREF0409_RS04740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMPREF0409_RS04745	COG0786	glutamate:sodium symporter activity
HMPREF0409_RS04755	COG0517	IMP dehydrogenase activity
HMPREF0409_RS04760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0409_RS04760	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF0409_RS04770	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HMPREF0409_RS04795	COG0346	lactoylglutathione lyase activity
HMPREF0409_RS04800	COG4804	nuclease activity
HMPREF0409_RS04860	COG1733	regulation of RNA biosynthetic process
HMPREF0409_RS04870	COG2996	Protein conserved in bacteria
HMPREF0409_RS04885	COG1687	branched-chain amino acid
HMPREF0409_RS04890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HMPREF0409_RS04935	COG0612	Peptidase, M16
HMPREF0409_RS04940	COG0756	dUTP diphosphatase activity
HMPREF0409_RS04945	COG0772	Belongs to the SEDS family
HMPREF0409_RS04950	COG0564	pseudouridine synthase activity
HMPREF0409_RS04955	COG2252	PERMEase
HMPREF0409_RS04960	COG0776	regulation of translation
HMPREF0409_RS04965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0409_RS04970	COG1024	Enoyl-CoA hydratase
HMPREF0409_RS04975	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMPREF0409_RS04990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF0409_RS04995	COG0285	dihydrofolate synthase activity
HMPREF0409_RS05005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMPREF0409_RS05010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF0409_RS05050	COG0531	amino acid
HMPREF0409_RS05055	COG0076	glutamate decarboxylase activity
HMPREF0409_RS05075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMPREF0409_RS05080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMPREF0409_RS05085	COG1363	Peptidase, m42
HMPREF0409_RS05090	COG0747	negative chemotaxis
HMPREF0409_RS05100	COG5522	Integral membrane protein (intg_mem_TP0381)
HMPREF0409_RS05115	COG1183	phosphatidylcholine synthase activity
HMPREF0409_RS05120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF0409_RS05125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF0409_RS05130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF0409_RS05135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMPREF0409_RS05140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMPREF0409_RS05145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMPREF0409_RS05155	COG0138	bifunctional purine biosynthesis protein purh
HMPREF0409_RS05165	COG0151	Belongs to the GarS family
HMPREF0409_RS05180	COG1757	Na H antiporter
HMPREF0409_RS05185	COG5295	Hep Hag repeat protein
HMPREF0409_RS05190	COG1492	cobalamin metabolic process
HMPREF0409_RS05210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF0409_RS05215	COG1797	cobyrinic acid a,c-diamide synthase activity
HMPREF0409_RS05220	COG3177	Filamentation induced by cAMP protein fic
HMPREF0409_RS05245	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HMPREF0409_RS05255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF0409_RS05265	COG1373	ATPase (AAA superfamily
HMPREF0409_RS05350	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HMPREF0409_RS05395	COG0534	Mate efflux family protein
HMPREF0409_RS05400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMPREF0409_RS05415	COG0494	nUDIX hydrolase
HMPREF0409_RS05420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF0409_RS05420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF0409_RS05425	COG0802	atpase or kinase
HMPREF0409_RS05430	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF0409_RS05460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF0409_RS05465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HMPREF0409_RS05475	COG0501	Belongs to the peptidase M48B family
HMPREF0409_RS05485	COG3210	domain, Protein
HMPREF0409_RS05485	COG3210	domain, Protein
HMPREF0409_RS05570	COG2190	(PTS) system
HMPREF0409_RS05585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HMPREF0409_RS05595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HMPREF0409_RS05600	COG2003	Belongs to the UPF0758 family
HMPREF0409_RS05605	COG1774	PSP1 C-terminal conserved region
HMPREF0409_RS05610	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0409_RS05615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF0409_RS05630	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HMPREF0409_RS05635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HMPREF0409_RS05635	COG0517	IMP dehydrogenase activity
HMPREF0409_RS05650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPREF0409_RS05655	COG4221	oxidoreductase activity
HMPREF0409_RS05680	COG0500	methyltransferase
HMPREF0409_RS05720	COG4974	Belongs to the 'phage' integrase family
HMPREF0409_RS05755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF0409_RS05770	COG1494	fructose-1,6-bisphosphatase
HMPREF0409_RS05780	COG0242	peptide deformylase activity
HMPREF0409_RS05785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF0409_RS05790	COG0768	penicillin binding
HMPREF0409_RS05795	COG1295	ribonuclease BN
HMPREF0409_RS05805	COG0436	Aminotransferase
HMPREF0409_RS05820	COG0297	glycogen (starch) synthase activity
HMPREF0409_RS05825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF0409_RS05830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF0409_RS05835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF0409_RS05840	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF0409_RS05870	COG0670	Belongs to the BI1 family
HMPREF0409_RS05875	COG0318	PFAM AMP-dependent synthetase and ligase
HMPREF0409_RS05880	COG0037	tRNA processing
HMPREF0409_RS05885	COG0561	phosphatase activity
HMPREF0409_RS05895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMPREF0409_RS05895	COG0248	Ppx GppA phosphatase
HMPREF0409_RS05905	COG0616	signal peptide processing
HMPREF0409_RS05910	COG0494	nUDIX hydrolase
HMPREF0409_RS05915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF0409_RS05935	COG4555	ABC transporter
HMPREF0409_RS05950	COG1164	Oligoendopeptidase f
HMPREF0409_RS05955	COG1854	S-ribosylhomocysteine lyase activity
HMPREF0409_RS05995	COG3681	Belongs to the UPF0597 family
HMPREF0409_RS06000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HMPREF0409_RS06005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0409_RS06015	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF0409_RS06020	COG1242	4 iron, 4 sulfur cluster binding
HMPREF0409_RS06025	COG2116	formate transmembrane transporter activity
HMPREF0409_RS06040	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPREF0409_RS06045	COG0557	exoribonuclease II activity
HMPREF0409_RS06050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF0409_RS06070	COG2375	cellular response to nickel ion
HMPREF0409_RS06070	COG1132	(ABC) transporter
HMPREF0409_RS06075	COG1132	(ABC) transporter
HMPREF0409_RS06100	COG0427	acetyl-CoA hydrolase
HMPREF0409_RS06105	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
HMPREF0409_RS06120	COG1757	Na H antiporter
HMPREF0409_RS06125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF0409_RS06130	COG1217	gtp-binding protein TYPA
HMPREF0409_RS06135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF0409_RS06180	COG0181	hydroxymethylbilane synthase activity
HMPREF0409_RS06185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMPREF0409_RS06190	COG0564	pseudouridine synthase activity
HMPREF0409_RS06200	COG0126	phosphoglycerate kinase activity
HMPREF0409_RS06225	COG2011	ABC-type metal ion transport system permease component
HMPREF0409_RS06230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0409_RS06240	COG0010	Belongs to the arginase family
HMPREF0409_RS06255	COG0534	Mate efflux family protein
HMPREF0409_RS06260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HMPREF0409_RS06270	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0409_RS06275	COG1121	(ABC) transporter
HMPREF0409_RS06280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0409_RS06285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0409_RS06295	COG1373	ATPase (AAA superfamily
HMPREF0409_RS06300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF0409_RS06315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMPREF0409_RS06335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HMPREF0409_RS06365	COG1162	GTPase activity
HMPREF0409_RS06370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF0409_RS06380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HMPREF0409_RS06390	COG2851	Citrate transporter
HMPREF0409_RS06410	COG1151	hydroxylamine reductase activity
HMPREF0409_RS06415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0409_RS06425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF0409_RS06430	COG0280	phosphate acetyltransferase
HMPREF0409_RS06435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF0409_RS06440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HMPREF0409_RS06440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF0409_RS06440	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF0409_RS06440	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF0409_RS06445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HMPREF0409_RS06450	COG4868	Belongs to the UPF0371 family
HMPREF0409_RS06455	COG1022	Amp-dependent synthetase and ligase
HMPREF0409_RS06460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0409_RS06465	COG2885	chlorophyll binding
HMPREF0409_RS06470	COG1704	LemA family
HMPREF0409_RS06490	COG1506	peptidase
HMPREF0409_RS06490	COG0823	Involved in the tonB-independent uptake of proteins
HMPREF0409_RS06490	COG4946	Tricorn protease homolog
HMPREF0409_RS06495	COG1196	nuclear chromosome segregation
HMPREF0409_RS06510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF0409_RS06515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPREF0409_RS06520	COG0492	ferredoxin-NADP+ reductase activity
HMPREF0409_RS06525	COG1940	carbohydrate kinase activity
HMPREF0409_RS06535	COG1129	ABC transporter
HMPREF0409_RS06540	COG4211	Belongs to the binding-protein-dependent transport system permease family
HMPREF0409_RS06550	COG0039	L-malate dehydrogenase activity
HMPREF0409_RS06555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF0409_RS06565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMPREF0409_RS06575	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HMPREF0409_RS06585	COG0601	transmembrane transport
HMPREF0409_RS06590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS06595	COG0747	negative chemotaxis
HMPREF0409_RS06600	COG0444	Belongs to the ABC transporter superfamily
HMPREF0409_RS06605	COG4608	Belongs to the ABC transporter superfamily
HMPREF0409_RS06610	COG1760	l-serine dehydratase
HMPREF0409_RS06620	COG0632	four-way junction helicase activity
HMPREF0409_RS06630	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HMPREF0409_RS06650	COG3872	metal-dependent enzyme
HMPREF0409_RS06655	COG2208	phosphoserine phosphatase activity
HMPREF0409_RS06660	COG0322	excinuclease ABC activity
HMPREF0409_RS06665	COG1660	Displays ATPase and GTPase activities
HMPREF0409_RS06670	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMPREF0409_RS06710	COG1132	(ABC) transporter
HMPREF0409_RS06740	COG0552	protein localization to endoplasmic reticulum
HMPREF0409_RS06750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0409_RS06755	COG4974	Belongs to the 'phage' integrase family
HMPREF0409_RS06760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HMPREF0409_RS06765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0409_RS06770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF0409_RS06770	COG0758	DNA mediated transformation
HMPREF0409_RS06775	COG1570	exodeoxyribonuclease VII activity
HMPREF0409_RS06780	COG1570	exodeoxyribonuclease VII activity
HMPREF0409_RS06795	COG1473	amidohydrolase
HMPREF0409_RS06800	COG2267	carboxylic ester hydrolase activity
HMPREF0409_RS06810	COG4884	unkown
HMPREF0409_RS06810	COG3831	ATPase activity
HMPREF0409_RS06815	COG1114	Component of the transport system for branched-chain amino acids
HMPREF0409_RS06830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HMPREF0409_RS06840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HMPREF0409_RS06875	COG1126	abc transporter atp-binding protein
HMPREF0409_RS06880	COG0765	amino acid transport
HMPREF0409_RS06890	COG0785	Cytochrome C biogenesis protein
HMPREF0409_RS06895	COG0310	cobalt ion transport
HMPREF0409_RS06910	COG1122	ATPase activity
HMPREF0409_RS06920	COG2385	sporulation resulting in formation of a cellular spore
HMPREF0409_RS06925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HMPREF0409_RS06930	COG0406	alpha-ribazole phosphatase activity
HMPREF0409_RS06950	COG0776	regulation of translation
HMPREF0409_RS06975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HMPREF0409_RS06975	COG1918	ferrous iron import across plasma membrane
HMPREF0409_RS06980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HMPREF0409_RS06980	COG1918	ferrous iron import across plasma membrane
HMPREF0409_RS06985	COG0534	Mate efflux family protein
HMPREF0409_RS06990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0409_RS07000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF0409_RS07005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF0409_RS07020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0409_RS07025	COG1136	(ABC) transporter
HMPREF0409_RS07040	COG2731	YhcH YjgK YiaL family protein
HMPREF0409_RS07045	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HMPREF0409_RS07050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HMPREF0409_RS07055	COG3639	organic phosphonate transmembrane transporter activity
HMPREF0409_RS07090	COG1132	(ABC) transporter
HMPREF0409_RS07095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMPREF0409_RS07105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMPREF0409_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HMPREF0409_RS07120	COG0210	DNA helicase
HMPREF0409_RS07125	COG1733	regulation of RNA biosynthetic process
HMPREF0409_RS07135	COG5002	protein histidine kinase activity
HMPREF0409_RS07150	COG1136	(ABC) transporter
HMPREF0409_RS07160	COG4953	penicillin-binding protein 1C
HMPREF0409_RS07170	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF0409_RS07190	COG0758	DNA mediated transformation
HMPREF0409_RS07205	COG0482	sulfurtransferase activity
HMPREF0409_RS07210	COG1799	cell septum assembly
HMPREF0409_RS07215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF0409_RS07220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF0409_RS07225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0409_RS07250	COG1396	sequence-specific DNA binding
HMPREF0409_RS07255	COG2610	gluconate transmembrane transporter activity
HMPREF0409_RS07260	COG3048	D-serine ammonia-lyase activity
HMPREF0409_RS07275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMPREF0409_RS07280	COG2137	regulation of response to DNA damage stimulus
HMPREF0409_RS07285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMPREF0409_RS07300	COG0859	PFAM glycosyl transferase family 9
HMPREF0409_RS07310	COG0463	Glycosyl transferase, family 2
HMPREF0409_RS07315	COG0726	polysaccharide deacetylase
HMPREF0409_RS07320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HMPREF0409_RS07325	COG1648	precorrin-2 dehydrogenase activity
HMPREF0409_RS07325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF0409_RS07335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HMPREF0409_RS07355	COG2855	membrane
HMPREF0409_RS07365	COG1278	Cold shock
HMPREF0409_RS07375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMPREF0409_RS07380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0409_RS07385	COG0210	DNA helicase
HMPREF0409_RS07400	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMPREF0409_RS07435	COG0426	domain, Protein
HMPREF0409_RS07440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF0409_RS07445	COG4667	esterase of the alpha-beta hydrolase superfamily
HMPREF0409_RS07455	COG0018	arginyl-trna synthetase
HMPREF0409_RS07460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0409_RS07470	COG0583	DNA-binding transcription factor activity
HMPREF0409_RS07475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HMPREF0409_RS07480	COG1982	Orn Lys Arg decarboxylase major
HMPREF0409_RS07510	COG0183	Belongs to the thiolase family
HMPREF0409_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0409_RS07525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF0409_RS07535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF0409_RS07545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF0409_RS07555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF0409_RS07560	COG0254	rRNA binding
HMPREF0409_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMPREF0409_RS07585	COG0739	heme binding
HMPREF0409_RS07590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HMPREF0409_RS07595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF0409_RS07600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMPREF0409_RS07605	COG1309	transcriptional regulator
HMPREF0409_RS07620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HMPREF0409_RS07630	COG1346	cytolysis
HMPREF0409_RS07640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF0409_RS07655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMPREF0409_RS07660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMPREF0409_RS07785	COG2831	hemolysin activation secretion protein
HMPREF0409_RS07790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF0409_RS07795	COG0113	porphobilinogen synthase activity
HMPREF0409_RS07820	COG1592	Rubrerythrin
HMPREF0409_RS07840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF0409_RS07875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HMPREF0409_RS07880	COG1914	H( )-stimulated, divalent metal cation uptake system
HMPREF0409_RS07885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HMPREF0409_RS07895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0409_RS07895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0409_RS07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0409_RS07920	COG1538	Outer membrane efflux protein
HMPREF0409_RS07940	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HMPREF0409_RS07960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0409_RS07970	COG4215	(ABC) transporter
HMPREF0409_RS07975	COG0765	amino acid transport
HMPREF0409_RS07980	COG1794	racemase activity, acting on amino acids and derivatives
HMPREF0409_RS07985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMPREF0409_RS07990	COG4974	Belongs to the 'phage' integrase family
HMPREF0409_RS07995	COG0497	DNA recombination
HMPREF0409_RS08000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMPREF0409_RS08030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0409_RS08060	COG4221	oxidoreductase activity
HMPREF0409_RS08070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF0409_RS08075	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF0409_RS08080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0409_RS08080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0409_RS08080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0409_RS08090	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF0409_RS08090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMPREF0409_RS08110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF0409_RS08115	COG0228	four-way junction DNA binding
HMPREF0409_RS08125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HMPREF0409_RS08145	COG2066	Belongs to the glutaminase family
HMPREF0409_RS08150	COG1115	amino acid carrier protein
HMPREF0409_RS08160	COG1288	antiporter activity
HMPREF0409_RS08165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMPREF0409_RS08175	COG0626	cystathionine gamma-synthase activity
HMPREF0409_RS08190	COG0426	domain, Protein
HMPREF0409_RS08190	COG1773	rubredoxin
HMPREF0409_RS08195	COG1960	acyl-CoA dehydrogenase activity
HMPREF0409_RS08205	COG0384	phenazine biosynthesis protein PhzF
HMPREF0409_RS08215	COG0640	Transcriptional regulator
HMPREF0409_RS08225	COG2217	Heavy metal translocating P-type atpase
HMPREF0409_RS08235	COG1288	antiporter activity
HMPREF0409_RS08255	COG2885	chlorophyll binding
HMPREF0409_RS08280	COG4115	mRNA cleavage
HMPREF0409_RS08320	COG2217	Heavy metal translocating P-type atpase
HMPREF0409_RS08340	COG0569	domain protein
HMPREF0409_RS08350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMPREF0409_RS08390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF0409_RS08395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF0409_RS08400	COG1116	anion transmembrane transporter activity
HMPREF0409_RS08420	COG1136	(ABC) transporter
HMPREF0409_RS08440	COG1136	(ABC) transporter
HMPREF0409_RS08445	COG1136	(ABC) transporter
HMPREF0409_RS08445	COG0577	efflux transmembrane transporter activity
HMPREF0409_RS08450	COG0577	efflux transmembrane transporter activity
HMPREF0409_RS08465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HMPREF0409_RS08470	COG0012	GTP binding
HMPREF0409_RS08475	COG0149	triose-phosphate isomerase activity
HMPREF0409_RS08485	COG1040	competence protein
HMPREF0409_RS08495	COG0792	nuclease activity
HMPREF0409_RS08500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF0409_RS08505	COG0564	pseudouridine synthase activity
HMPREF0409_RS08510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF0409_RS08535	COG3052	prosthetic group binding
HMPREF0409_RS08555	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF0409_RS08560	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HMPREF0409_RS08565	COG0714	Associated with various cellular activities
HMPREF0409_RS08605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF0409_RS08630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF0409_RS08635	COG0335	large ribosomal subunit rRNA binding
HMPREF0409_RS08645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HMPREF0409_RS08650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF0409_RS08660	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF0409_RS08670	COG0167	dihydroorotate dehydrogenase activity
HMPREF0409_RS08675	COG0543	2 iron, 2 sulfur cluster binding
HMPREF0409_RS08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HMPREF0409_RS08685	COG0505	Belongs to the CarA family
HMPREF0409_RS08690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF0409_RS08695	COG0540	Belongs to the ATCase OTCase family
HMPREF0409_RS08700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMPREF0409_RS08715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF0409_RS08720	COG2926	Belongs to the UPF0265 family
HMPREF0409_RS08725	COG0205	6-phosphofructokinase activity
HMPREF0409_RS08730	COG0825	malonyl-CoA metabolic process
HMPREF0409_RS08735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMPREF0409_RS08745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF0409_RS08750	COG0180	Tryptophanyl-tRNA synthetase
HMPREF0409_RS08755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF0409_RS08775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF0409_RS08780	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF0409_RS08785	COG0084	hydrolase, TatD family'
HMPREF0409_RS08795	COG2985	domain, Protein
HMPREF0409_RS08795	COG0569	domain protein
HMPREF0409_RS08800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMPREF0409_RS08815	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF0409_RS08820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF0409_RS08825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMPREF0409_RS08830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF0409_RS08835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF0409_RS08840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF0409_RS08845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0409_RS08855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMPREF0409_RS08865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF0409_RS08870	COG0789	Transcriptional regulator
HMPREF0409_RS08900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMPREF0409_RS08945	COG2239	Acts as a magnesium transporter
HMPREF0409_RS08950	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF0409_RS08955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF0409_RS08960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0409_RS08975	COG1253	flavin adenine dinucleotide binding
HMPREF0409_RS08980	COG4492	Belongs to the UPF0735 family
HMPREF0409_RS08985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF0409_RS08990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF0409_RS08995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0409_RS09000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0409_RS09000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0409_RS09000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0409_RS09005	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF0409_RS09020	COG2814	Major facilitator Superfamily
HMPREF0409_RS09025	COG0456	acetyltransferase
HMPREF0409_RS09030	COG0201	protein transport
HMPREF0409_RS09035	COG0200	Binds to the 23S rRNA
HMPREF0409_RS09040	COG1841	ribosomal large subunit assembly
HMPREF0409_RS09045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF0409_RS09050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMPREF0409_RS09055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMPREF0409_RS09060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF0409_RS09065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF0409_RS09070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF0409_RS09080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF0409_RS09085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF0409_RS09090	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF0409_RS09095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMPREF0409_RS09100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMPREF0409_RS09105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMPREF0409_RS09110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF0409_RS09115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF0409_RS09120	COG0089	rRNA binding
HMPREF0409_RS09125	COG0088	Forms part of the polypeptide exit tunnel
HMPREF0409_RS09130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMPREF0409_RS09135	COG0051	transcription antitermination factor activity, RNA binding
HMPREF0409_RS09145	COG4608	Belongs to the ABC transporter superfamily
HMPREF0409_RS09150	COG0444	Belongs to the ABC transporter superfamily
HMPREF0409_RS09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS09165	COG0747	negative chemotaxis
HMPREF0409_RS09170	COG0534	Mate efflux family protein
HMPREF0409_RS09185	COG0444	Belongs to the ABC transporter superfamily
HMPREF0409_RS09190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS09195	COG0601	transmembrane transport
HMPREF0409_RS09200	COG0747	negative chemotaxis
HMPREF0409_RS09205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HMPREF0409_RS09210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMPREF0409_RS09210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMPREF0409_RS09220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0409_RS09220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0409_RS09250	COG0495	leucyl-tRNA aminoacylation
HMPREF0409_RS09255	COG1595	DNA-templated transcription, initiation
HMPREF0409_RS09260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF0409_RS09265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF0409_RS09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0409_RS09290	COG0747	negative chemotaxis
HMPREF0409_RS09295	COG0444	Belongs to the ABC transporter superfamily
HMPREF0409_RS09300	COG4608	Belongs to the ABC transporter superfamily
HMPREF0409_RS09330	COG1346	cytolysis
HMPREF0409_RS09335	COG1380	Effector of murein hydrolase LrgA
HMPREF0409_RS09340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HMPREF0409_RS09355	COG0277	FAD linked oxidase domain protein
HMPREF0409_RS09360	COG0003	Pfam Anion-transporting ATPase
HMPREF0409_RS09365	COG0003	Pfam Anion-transporting ATPase
HMPREF0409_RS09370	COG1556	Lactate utilization protein
HMPREF0409_RS09375	COG1139	Iron-sulfur cluster binding protein
HMPREF0409_RS09380	COG0142	geranyltranstransferase activity
HMPREF0409_RS09395	COG0644	oxidoreductase
HMPREF0409_RS09415	COG2337	Toxic component of a toxin-antitoxin (TA) module
HMPREF0409_RS09430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF0409_RS09435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0409_RS09435	COG2190	(PTS) system
HMPREF0409_RS09435	COG1263	PTS System
HMPREF0409_RS09465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF0409_RS09470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF0409_RS09475	COG0049	tRNA binding
HMPREF0409_RS09480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMPREF0409_RS09485	COG3263	regulation of cellular component size
HMPREF0409_RS09495	COG1496	oxidoreductase activity
HMPREF0409_RS09500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HMPREF0409_RS09565	COG2827	Endonuclease containing a URI domain
HMPREF0409_RS09570	COG0470	DNA polymerase III
HMPREF0409_RS09580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF0409_RS09585	COG0215	cysteine-tRNA ligase activity
HMPREF0409_RS09595	COG1193	negative regulation of DNA recombination
HMPREF0409_RS09620	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF0409_RS09625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF0409_RS09635	COG2878	Part of a membrane complex involved in electron transport
HMPREF0409_RS09635	COG1245	4Fe-4S binding domain
HMPREF0409_RS09640	COG4657	Part of a membrane complex involved in electron transport
HMPREF0409_RS09645	COG4660	Part of a membrane complex involved in electron transport
HMPREF0409_RS09650	COG4659	FMN binding
HMPREF0409_RS09655	COG4658	electron transport chain
HMPREF0409_RS09660	COG4656	Part of a membrane complex involved in electron transport
HMPREF0409_RS09665	COG0193	aminoacyl-tRNA hydrolase activity
HMPREF0409_RS09755	COG3210	domain, Protein
HMPREF0409_RS09765	COG0101	tRNA pseudouridine synthase activity
HMPREF0409_RS09775	COG4115	mRNA cleavage
HMPREF0409_RS09785	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF0409_RS09790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMPREF0409_RS09800	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HMPREF0409_RS09810	COG0484	heat shock protein binding
HMPREF0409_RS09815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF0409_RS09820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0409_RS09825	COG0009	L-threonylcarbamoyladenylate synthase
HMPREF0409_RS09840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HMPREF0409_RS09845	COG0534	Mate efflux family protein
HMPREF0409_RS09850	COG0542	response to heat
HMPREF0409_RS09855	COG3041	Addiction module toxin RelE StbE family
HMPREF0409_RS09870	COG2964	Protein conserved in bacteria
HMPREF0409_RS09880	COG0733	neurotransmitter:sodium symporter activity
HMPREF0409_RS09885	COG1115	amino acid carrier protein
HMPREF0409_RS09890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0409_RS09950	COG1120	ATPase activity
HMPREF0409_RS09955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0409_RS09965	COG4206	TonB-dependent receptor
HMPREF0409_RS09975	COG4221	oxidoreductase activity
HMPREF0409_RS09980	COG0251	oxidation-reduction process
HMPREF0409_RS10015	COG0513	Belongs to the DEAD box helicase family
HMPREF0409_RS10020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF0409_RS10025	COG0037	tRNA processing
HMPREF0409_RS10030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0409_RS10035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMPREF0409_RS10055	COG4452	Inner membrane protein CreD
HMPREF0409_RS10065	COG1802	Transcriptional regulator
HMPREF0409_RS10070	COG3033	Beta-eliminating lyase
HMPREF0409_RS10075	COG0733	neurotransmitter:sodium symporter activity
HMPREF0409_RS10080	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF0409_RS10085	COG0445	tRNA wobble uridine modification
HMPREF0409_RS10090	COG0569	domain protein
HMPREF0409_RS10095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF0409_RS10100	COG0534	Mate efflux family protein
HMPREF0409_RS10110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF0409_RS10115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF0409_RS10120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF0409_RS10125	COG0512	Glutamine amidotransferase of anthranilate synthase
HMPREF0409_RS10125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF0409_RS10135	COG1394	ATPase activity, coupled to movement of substances
HMPREF0409_RS10140	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HMPREF0409_RS10150	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HMPREF0409_RS10155	COG1527	subunit (C
HMPREF0409_RS10160	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HMPREF0409_RS10165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0409_RS10170	COG1269	ATP hydrolysis coupled proton transport
HMPREF0409_RS10180	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0409_RS10190	COG2022	thiamine diphosphate biosynthetic process
HMPREF0409_RS10195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HMPREF0409_RS10205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HMPREF0409_RS10210	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0409_RS10240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF0409_RS10245	COG1477	protein flavinylation
HMPREF0409_RS10255	COG0194	GDP metabolic process
HMPREF0409_RS10260	COG1561	YicC-like family, N-terminal region
HMPREF0409_RS10265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF0409_RS10270	COG0085	RNA polymerase activity
HMPREF0409_RS10275	COG0222	ribosome binding
HMPREF0409_RS10280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF0409_RS10285	COG0081	regulation of translation
HMPREF0409_RS10290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF0409_RS10295	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF0409_RS10310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0409_RS10315	COG0735	belongs to the Fur family
HMPREF0409_RS10335	COG0166	Belongs to the GPI family
HMPREF0409_RS10345	COG0647	UMP catabolic process
HMPREF0409_RS10350	COG0708	Exodeoxyribonuclease III
HMPREF0409_RS10355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HMPREF0409_RS10360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF0409_RS10375	COG0772	Belongs to the SEDS family
HMPREF0409_RS10385	COG0017	Asparaginyl-tRNA synthetase
HMPREF0409_RS10390	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMPREF0409_RS10460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HMPREF0409_RS10480	COG2885	chlorophyll binding
HMPREF0409_RS10525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0409_RS10530	COG1078	dGTPase activity
HMPREF0409_RS10535	COG1115	amino acid carrier protein
HMPREF0409_RS10545	COG1492	cobalamin metabolic process
HMPREF0409_RS10560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0409_RS10565	COG1757	Na H antiporter
HMPREF0409_RS10575	COG1288	antiporter activity
HMPREF0409_RS10580	COG2088	sporulation resulting in formation of a cellular spore
HMPREF0409_RS10590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPREF0409_RS10595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMPREF0409_RS10600	COG4115	mRNA cleavage
HMPREF0409_RS10635	COG0563	adenylate kinase activity
HMPREF0409_RS10640	COG1827	regulation of RNA biosynthetic process
HMPREF0409_RS10645	COG0157	Belongs to the NadC ModD family
HMPREF0409_RS10655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HMPREF0409_RS10665	COG0445	tRNA wobble uridine modification
HMPREF0409_RS10670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMPREF0409_RS10675	COG1847	R3H domain protein
HMPREF0409_RS10680	COG0706	membrane insertase activity
HMPREF0409_RS10685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMPREF0409_RS10690	COG0594	ribonuclease P activity
HMPREF0409_RS10745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0409_RS10750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner