locus-tag	class	description
FN0002	COG0594	ribonuclease P activity
FN0003	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FN0004	COG0706	membrane insertase activity
FN0005	COG1847	R3H domain protein
FN0006	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FN0007	COG0445	tRNA wobble uridine modification
FN0008	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FN0010	COG0157	Belongs to the NadC ModD family
FN0011	COG1827	regulation of RNA biosynthetic process
FN0019	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FN0020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FN0021	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FN0022	COG2088	sporulation resulting in formation of a cellular spore
FN0023	COG1288	antiporter activity
FN0039	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FN0040	COG0017	Asparaginyl-tRNA synthetase
FN0041	COG4224	UPF0291 protein
FN0042	COG0772	Belongs to the SEDS family
FN0045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FN0046	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FN0047	COG0708	Exodeoxyribonuclease III
FN0048	COG0647	UMP catabolic process
FN0052	COG1393	Belongs to the ArsC family
FN0053	COG1114	Component of the transport system for branched-chain amino acids
FN0054	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FN0057	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FN0058	COG1104	cysteine desulfurase activity
FN0059	COG0822	iron-sulfur transferase activity
FN0061	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FN0065	COG2183	response to ionizing radiation
FN0066	COG2205	protein histidine kinase activity
FN0067	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FN0068	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FN0069	COG0752	glycyl-tRNA synthetase alpha subunit
FN0070	COG0751	glycine-tRNA ligase activity
FN0071	COG0302	gtp cyclohydrolase
FN0072	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FN0072	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FN0073	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FN0079	COG4303	Ethanolamine ammonia lyase large subunit
FN0080	COG4302	ethanolamine ammonia-lyase activity
FN0081	COG4816	utilization protein
FN0082	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FN0084	COG1012	belongs to the aldehyde dehydrogenase family
FN0084	COG1454	alcohol dehydrogenase
FN0089	COG3192	ethanolamine utilization protein
FN0093	COG3118	belongs to the thioredoxin family
FN0099	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FN0100	COG2871	sodium ion transport
FN0102	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FN0103	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FN0107	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FN0108	COG1619	proteins homologs of microcin C7 resistance protein MccF
FN0110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FN0113	COG1420	regulation of RNA biosynthetic process
FN0114	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FN0116	COG0443	Heat shock 70 kDa protein
FN0118	COG0484	heat shock protein binding
FN0127	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FN0127	COG0731	radical SAM domain protein
FN0129	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FN0130	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FN0131	COG2831	hemolysin activation secretion protein
FN0132	COG3210	domain, Protein
FN0132	COG3210	domain, Protein
FN0139	COG2801	Transposase and inactivated derivatives
FN0147	COG0416	fatty acid biosynthetic process
FN0148	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FN0149	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FN0150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FN0151	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FN0152	COG0571	ribonuclease III activity
FN0153	COG1242	4 iron, 4 sulfur cluster binding
FN0154	COG1530	ribonuclease E activity
FN0156	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FN0157	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FN0158	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FN0162	COG0534	Mate efflux family protein
FN0163	COG1410	methionine synthase
FN0163	COG0646	methionine synthase
FN0164	COG3023	N-Acetylmuramoyl-L-alanine amidase
FN0170	COG1160	GTP binding
FN0174	COG2070	2-Nitropropane dioxygenase
FN0175	COG0850	regulation of cytokinetic process
FN0176	COG2894	cell division
FN0177	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FN0183	COG0579	oxidoreductase
FN0186	COG0785	Cytochrome C biogenesis protein
FN0187	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FN0188	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FN0188	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FN0190	COG2972	Histidine kinase
FN0192	COG0747	negative chemotaxis
FN0193	COG0601	transmembrane transport
FN0194	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN0200	COG0511	ligase activity, forming carbon-carbon bonds
FN0200	COG5016	pyruvate
FN0201	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FN0202	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FN0203	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FN0204	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FN0205	COG0786	glutamate:sodium symporter activity
FN0206	COG1924	4 iron, 4 sulfur cluster binding
FN0207	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FN0208	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FN0213	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FN0214	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FN0215	COG1285	pathogenesis
FN0216	COG4221	oxidoreductase activity
FN0218	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FN0219	COG3279	Response regulator of the LytR AlgR family
FN0220	COG3275	phosphorelay sensor kinase activity
FN0221	COG1966	Carbon starvation protein
FN0222	COG2211	Major facilitator Superfamily
FN0224	COG0556	nucleotide-excision repair
FN0225	COG2610	gluconate transmembrane transporter activity
FN0226	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FN0227	COG3395	kinase activity
FN0228	COG1349	DNA-binding transcription factor activity
FN0235	COG1116	anion transmembrane transporter activity
FN0236	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FN0237	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FN0240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FN0242	COG0569	domain protein
FN0244	COG2217	Heavy metal translocating P-type atpase
FN0245	COG2217	Heavy metal translocating P-type atpase
FN0257	COG1288	antiporter activity
FN0258	COG2217	Heavy metal translocating P-type atpase
FN0260	COG0640	Transcriptional regulator
FN0267	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FN0268	COG0497	DNA recombination
FN0270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FN0271	COG1024	Enoyl-CoA hydratase
FN0272	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FN0273	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FN0276	COG1283	sodium-dependent phosphate transmembrane transporter activity
FN0278	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FN0282	COG4752	Belongs to the RNA methyltransferase TrmD family
FN0283	COG0336	Belongs to the RNA methyltransferase TrmD family
FN0284	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FN0285	COG1837	Belongs to the UPF0109 family
FN0287	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FN0288	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FN0291	COG3210	domain, Protein
FN0291	COG3210	domain, Protein
FN0294	COG3959	Transketolase, thiamine diphosphate binding domain
FN0295	COG3958	Transketolase
FN0297	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FN0298	COG0124	histidyl-tRNA synthetase
FN0299	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FN0300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FN0301	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FN0303	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FN0304	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FN0306	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FN0307	COG1120	ATPase activity
FN0309	COG1176	ABC-type spermidine putrescine transport system, permease component I
FN0310	COG3842	ATPase activity
FN0311	COG1328	CTP reductase activity
FN0311	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FN0312	COG0602	queuosine metabolic process
FN0313	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FN0313	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FN0315	COG2207	Transcriptional regulator
FN0315	COG3708	Transcriptional regulator
FN0317	COG0133	tryptophan synthase activity
FN0319	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FN0321	COG0326	Molecular chaperone. Has ATPase activity
FN0322	COG3588	fructose-bisphosphate aldolase
FN0325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FN0326	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FN0327	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FN0328	COG1115	amino acid carrier protein
FN0329	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FN0330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FN0332	COG0598	Magnesium transport protein CorA
FN0333	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FN0340	COG3314	Sporulation integral membrane protein YlbJ
FN0341	COG2056	Na+-H+ antiporter family
FN0342	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FN0344	COG0116	Belongs to the methyltransferase superfamily
FN0347	COG0688	phosphatidylethanolamine metabolic process
FN0348	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FN0349	COG1490	D-aminoacyl-tRNA deacylase activity
FN0352	COG1757	Na H antiporter
FN0355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FN0357	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FN0358	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FN0359	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FN0360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FN0361	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FN0362	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FN0363	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FN0366	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FN0368	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FN0370	COG0681	Belongs to the peptidase S26 family
FN0374	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FN0374	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FN0375	COG1840	ABC-type Fe3 transport system, periplasmic component
FN0376	COG3842	ATPase activity
FN0377	COG1176	ABC-type spermidine putrescine transport system, permease component I
FN0378	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FN0383	COG0297	glycogen (starch) synthase activity
FN0386	COG2342	PFAM TM1410 hypothetical-related protein
FN0388	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FN0391	COG0561	phosphatase activity
FN0393	COG0726	polysaccharide deacetylase
FN0396	COG0747	negative chemotaxis
FN0397	COG0601	transmembrane transport
FN0398	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN0399	COG0444	Belongs to the ABC transporter superfamily
FN0400	COG4608	Belongs to the ABC transporter superfamily
FN0405	COG0180	Tryptophanyl-tRNA synthetase
FN0406	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FN0408	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FN0409	COG0825	malonyl-CoA metabolic process
FN0410	COG0205	6-phosphofructokinase activity
FN0411	COG2926	Belongs to the UPF0265 family
FN0412	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FN0418	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FN0419	COG0540	Belongs to the ATCase OTCase family
FN0420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FN0421	COG0505	Belongs to the CarA family
FN0422	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FN0423	COG0543	2 iron, 2 sulfur cluster binding
FN0424	COG0167	dihydroorotate dehydrogenase activity
FN0426	COG0284	orotidine-5'-phosphate decarboxylase activity
FN0427	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FN0428	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FN0430	COG0335	large ribosomal subunit rRNA binding
FN0435	COG0813	purine-nucleoside phosphorylase activity
FN0436	COG1984	allophanate hydrolase subunit 2
FN0437	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FN0438	COG1914	H( )-stimulated, divalent metal cation uptake system
FN0439	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FN0447	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FN0450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FN0452	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FN0455	COG1592	Rubrerythrin
FN0460	COG0113	porphobilinogen synthase activity
FN0461	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FN0462	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FN0463	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FN0466	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FN0468	COG1346	cytolysis
FN0470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FN0473	COG1309	transcriptional regulator
FN0475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FN0476	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FN0477	COG0739	heme binding
FN0478	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FN0482	COG0254	rRNA binding
FN0483	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FN0486	COG2801	Transposase and inactivated derivatives
FN0487	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FN0489	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FN0491	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FN0494	COG1028	Short-chain dehydrogenase reductase Sdr
FN0495	COG0183	Belongs to the thiolase family
FN0501	COG1982	Orn Lys Arg decarboxylase major
FN0502	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FN0503	COG0583	DNA-binding transcription factor activity
FN0505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FN0506	COG0018	arginyl-trna synthetase
FN0508	COG4667	esterase of the alpha-beta hydrolase superfamily
FN0511	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FN0512	COG0426	domain, Protein
FN0521	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FN0524	COG0210	DNA helicase
FN0525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FN0526	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FN0528	COG1278	Cold shock
FN0533	COG2855	membrane
FN0537	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FN0539	COG1648	precorrin-2 dehydrogenase activity
FN0539	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FN0540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FN0541	COG0726	polysaccharide deacetylase
FN0542	COG0463	Glycosyl transferase, family 2
FN0544	COG0859	PFAM glycosyl transferase family 9
FN0547	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FN0548	COG2137	regulation of response to DNA damage stimulus
FN0549	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FN0553	COG3048	D-serine ammonia-lyase activity
FN0554	COG2610	gluconate transmembrane transporter activity
FN0559	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FN0560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FN0561	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FN0562	COG1799	cell septum assembly
FN0563	COG0482	sulfurtransferase activity
FN0576	COG2304	oxidoreductase activity
FN0578	COG0514	ATP-dependent DNA helicase (RecQ)
FN0580	COG4953	penicillin-binding protein 1C
FN0582	COG1136	(ABC) transporter
FN0586	COG3850	Histidine kinase
FN0586	COG5002	protein histidine kinase activity
FN0589	COG1733	regulation of RNA biosynthetic process
FN0591	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FN0594	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FN0595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FN0597	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FN0598	COG1132	(ABC) transporter
FN0603	COG0583	DNA-binding transcription factor activity
FN0604	COG1301	dicarboxylic acid transport
FN0607	COG1713	HD superfamily hydrolase involved in NAD metabolism
FN0608	COG0557	exoribonuclease II activity
FN0609	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FN0611	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FN0614	COG2375	cellular response to nickel ion
FN0614	COG1132	(ABC) transporter
FN0615	COG1132	(ABC) transporter
FN0617	COG0592	DNA-directed DNA polymerase activity
FN0619	COG0668	transmembrane transport
FN0621	COG0427	acetyl-CoA hydrolase
FN0622	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
FN0624	COG1757	Na H antiporter
FN0625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FN0627	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FN0629	COG3716	PTS system mannose fructose sorbose family IID component
FN0630	COG3715	PTS system
FN0634	COG1217	gtp-binding protein TYPA
FN0635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FN0645	COG0181	hydroxymethylbilane synthase activity
FN0646	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FN0649	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FN0650	COG1757	Na H antiporter
FN0651	COG0564	pseudouridine synthase activity
FN0654	COG0126	phosphoglycerate kinase activity
FN0659	COG2011	ABC-type metal ion transport system permease component
FN0660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FN0662	COG0010	Belongs to the arginase family
FN0667	COG0534	Mate efflux family protein
FN0668	COG0803	Belongs to the bacterial solute-binding protein 9 family
FN0669	COG1121	(ABC) transporter
FN0670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FN0671	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FN0672	COG1373	ATPase (AAA superfamily
FN0673	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FN0675	COG0459	protein refolding
FN0676	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FN0679	COG1162	GTPase activity
FN0680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FN0682	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FN0684	COG1151	hydroxylamine reductase activity
FN0685	COG4145	pantothenate transmembrane transporter activity
FN0693	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FN0695	COG1137	ATPase activity
FN0697	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FN0698	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FN0699	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FN0700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FN0701	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FN0701	COG4797	methyltransferase
FN0703	COG1473	amidohydrolase
FN0705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FN0705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FN0707	COG0196	riboflavin kinase activity
FN0709	COG0728	peptidoglycan biosynthetic process
FN0711	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FN0717	COG1187	pseudouridine synthase activity
FN0720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FN0724	COG0716	FMN binding
FN0725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FN0729	COG0588	phosphoglycerate mutase activity
FN0730	COG0588	phosphoglycerate mutase activity
FN0732	COG1323	Belongs to the UPF0348 family
FN0733	COG2195	Cleaves the N-terminal amino acid of tripeptides
FN0734	COG1032	radical SAM domain protein
FN0739	COG3404	Formiminotransferase-cyclodeaminase
FN0740	COG1228	amidohydrolase
FN0742	COG4807	Protein conserved in bacteria
FN0743	COG1199	ATP-dependent helicase activity
FN0745	COG1480	7TM receptor with intracellular HD hydrolase
FN0746	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FN0751	COG0252	asparaginase activity
FN0753	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FN0754	COG0154	amidase activity
FN0755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FN0756	COG1187	pseudouridine synthase activity
FN0757	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FN0758	COG1077	Cell shape determining protein MreB Mrl
FN0759	COG0424	maF-like protein
FN0761	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FN0765	COG0482	sulfurtransferase activity
FN0766	COG1970	mechanosensitive ion channel activity
FN0767	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FN0768	COG4206	TonB-dependent receptor
FN0769	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FN0770	COG1120	ATPase activity
FN0771	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FN0775	COG1362	aminopeptidase activity
FN0776	COG2502	aspartate--ammonia ligase
FN0777	COG0481	GTPase activity
FN0781	COG2966	Psort location CytoplasmicMembrane, score
FN0783	COG1960	acyl-CoA dehydrogenase activity
FN0784	COG2086	electron transfer activity
FN0785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FN0787	COG2801	Transposase and inactivated derivatives
FN0789	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FN0790	COG1940	carbohydrate kinase activity
FN0791	COG2986	histidine ammonia-lyase
FN0792	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FN0793	COG0786	glutamate:sodium symporter activity
FN0795	COG0517	IMP dehydrogenase activity
FN0796	COG0574	Belongs to the PEP-utilizing enzyme family
FN0796	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FN0798	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FN0800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FN0801	COG1126	abc transporter atp-binding protein
FN0802	COG0765	amino acid transport
FN0804	COG0785	Cytochrome C biogenesis protein
FN0806	COG2385	sporulation resulting in formation of a cellular spore
FN0807	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FN0808	COG0406	alpha-ribazole phosphatase activity
FN0809	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FN0813	COG1309	transcriptional regulator
FN0814	COG4670	ketone body catabolic process
FN0815	COG2610	gluconate transmembrane transporter activity
FN0816	COG2030	dehydratase
FN0818	COG0776	regulation of translation
FN0820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FN0822	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FN0823	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FN0826	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FN0827	COG1136	(ABC) transporter
FN0828	COG0577	efflux transmembrane transporter activity
FN0831	COG4771	TonB-dependent receptor
FN0841	COG2801	Transposase and inactivated derivatives
FN0851	COG0500	methyltransferase
FN0853	COG0297	glycogen (starch) synthase activity
FN0854	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FN0855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FN0856	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FN0857	COG0058	SHG alpha-glucan phosphorylase activity
FN0867	COG0318	PFAM AMP-dependent synthetase and ligase
FN0868	COG0037	tRNA processing
FN0869	COG0561	phosphatase activity
FN0870	COG1054	Belongs to the UPF0176 family
FN0871	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FN0871	COG0248	Ppx GppA phosphatase
FN0873	COG0616	signal peptide processing
FN0874	COG0494	nUDIX hydrolase
FN0875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FN0876	COG0405	Gamma-glutamyltransferase
FN0878	COG1802	Transcriptional regulator
FN0880	COG4555	ABC transporter
FN0882	COG1120	ATPase activity
FN0884	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FN0887	COG1164	Oligoendopeptidase f
FN0899	COG1028	Short-chain dehydrogenase reductase Sdr
FN0900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FN0903	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FN0903	COG0517	IMP dehydrogenase activity
FN0904	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FN0906	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FN0907	COG2890	protein-(glutamine-N5) methyltransferase activity
FN0908	COG1774	PSP1 C-terminal conserved region
FN0909	COG2003	Belongs to the UPF0758 family
FN0910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FN0911	COG0406	alpha-ribazole phosphatase activity
FN0912	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FN0915	COG2190	(PTS) system
FN0920	COG0501	Belongs to the peptidase M48B family
FN0922	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FN0928	COG1214	PFAM Peptidase M22, glycoprotease
FN0929	COG0802	atpase or kinase
FN0930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FN0930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FN0931	COG0494	nUDIX hydrolase
FN0934	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FN0941	COG0405	Gamma-glutamyltransferase
FN0942	COG3852	Histidine kinase
FN0943	COG0745	RESPONSE REGULATOR receiver
FN0949	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FN0965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FN0967	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FN0971	COG3177	Filamentation induced by cAMP protein fic
FN0972	COG1797	cobyrinic acid a,c-diamide synthase activity
FN0973	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FN0977	COG1492	cobalamin metabolic process
FN0978	COG1757	Na H antiporter
FN0981	COG0151	Belongs to the GarS family
FN0982	COG0138	bifunctional purine biosynthesis protein purh
FN0985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FN0986	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FN0987	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FN0988	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FN0989	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FN0990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FN0991	COG1183	phosphatidylcholine synthase activity
FN0996	COG5522	Integral membrane protein (intg_mem_TP0381)
FN0998	COG0747	negative chemotaxis
FN0999	COG1363	Peptidase, m42
FN1000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FN1001	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FN1011	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FN1012	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FN1015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FN1019	COG1250	3-hydroxyacyl-CoA dehydrogenase
FN1020	COG1024	Enoyl-CoA hydratase
FN1022	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FN1024	COG0776	regulation of translation
FN1025	COG2252	PERMEase
FN1027	COG0772	Belongs to the SEDS family
FN1028	COG0756	dUTP diphosphatase activity
FN1029	COG0612	Peptidase, M16
FN1039	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FN1040	COG1687	branched-chain amino acid
FN1042	COG2996	Protein conserved in bacteria
FN1050	COG0346	lactoylglutathione lyase activity
FN1055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FN1059	COG1114	Component of the transport system for branched-chain amino acids
FN1060	COG3831	ATPase activity
FN1060	COG4884	unkown
FN1063	COG1473	amidohydrolase
FN1066	COG1570	exodeoxyribonuclease VII activity
FN1068	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FN1068	COG0758	DNA mediated transformation
FN1069	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FN1070	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FN1071	COG4974	Belongs to the 'phage' integrase family
FN1072	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FN1074	COG0552	protein localization to endoplasmic reticulum
FN1080	COG1132	(ABC) transporter
FN1088	COG0446	pyridine nucleotide-disulphide oxidoreductase
FN1089	COG1660	Displays ATPase and GTPase activities
FN1090	COG0322	excinuclease ABC activity
FN1091	COG2208	phosphoserine phosphatase activity
FN1092	COG3872	metal-dependent enzyme
FN1102	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FN1104	COG0632	four-way junction helicase activity
FN1106	COG1760	l-serine dehydratase
FN1110	COG0444	Belongs to the ABC transporter superfamily
FN1111	COG0747	negative chemotaxis
FN1112	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN1113	COG0601	transmembrane transport
FN1115	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FN1117	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FN1119	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FN1120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FN1121	COG4868	Belongs to the UPF0371 family
FN1122	COG1022	Amp-dependent synthetase and ligase
FN1123	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FN1124	COG2885	chlorophyll binding
FN1125	COG1704	LemA family
FN1128	COG1506	peptidase
FN1128	COG0823	Involved in the tonB-independent uptake of proteins
FN1128	COG4946	Tricorn protease homolog
FN1129	COG1196	nuclear chromosome segregation
FN1132	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FN1133	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FN1134	COG2731	YhcH YjgK YiaL family protein
FN1135	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FN1136	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FN1137	COG3639	organic phosphonate transmembrane transporter activity
FN1141	COG2116	formate transmembrane transporter activity
FN1142	COG1242	4 iron, 4 sulfur cluster binding
FN1143	COG0363	glucosamine-6-phosphate deaminase activity
FN1147	COG3681	Belongs to the UPF0597 family
FN1149	COG0210	DNA helicase
FN1151	COG0534	Mate efflux family protein
FN1154	COG1295	ribonuclease BN
FN1155	COG0768	penicillin binding
FN1156	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FN1157	COG0242	peptide deformylase activity
FN1159	COG1494	fructose-1,6-bisphosphatase
FN1161	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FN1162	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FN1164	COG1940	carbohydrate kinase activity
FN1166	COG1129	ABC transporter
FN1167	COG4211	Belongs to the binding-protein-dependent transport system permease family
FN1169	COG0039	L-malate dehydrogenase activity
FN1170	COG1013	pyruvate-flavodoxin oxidoreductase activity
FN1170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FN1170	COG0674	pyruvate-flavodoxin oxidoreductase activity
FN1170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FN1171	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FN1172	COG0280	phosphate acetyltransferase
FN1176	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FN1177	COG1518	maintenance of DNA repeat elements
FN1185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FN1187	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FN1199	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FN1202	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FN1204	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FN1205	COG0793	Belongs to the peptidase S41A family
FN1205	COG3409	Peptidoglycan-binding domain 1 protein
FN1206	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FN1208	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FN1209	COG1534	Rna-binding protein
FN1210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FN1211	COG0768	penicillin binding
FN1214	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FN1215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FN1217	COG2255	four-way junction helicase activity
FN1218	COG4399	Belongs to the UPF0754 family
FN1220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FN1224	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FN1225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FN1226	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FN1231	COG0516	GMP reductase activity
FN1231	COG0517	IMP dehydrogenase activity
FN1232	COG1733	regulation of RNA biosynthetic process
FN1233	COG2249	NAD(P)H dehydrogenase (quinone) activity
FN1237	COG4750	Nucleotidyl transferase
FN1243	COG1216	Glycosyl transferase, family 2
FN1244	COG0726	polysaccharide deacetylase
FN1246	COG3475	LICD family
FN1247	COG0859	PFAM glycosyl transferase family 9
FN1249	COG2378	regulation of single-species biofilm formation
FN1250	COG2252	PERMEase
FN1251	COG0672	)-iron permease
FN1254	COG0778	Nitroreductase
FN1255	COG0647	UMP catabolic process
FN1256	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FN1258	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FN1259	COG1573	uracil-dna glycosylase
FN1260	COG3850	Histidine kinase
FN1260	COG5002	protein histidine kinase activity
FN1265	COG2885	chlorophyll binding
FN1266	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FN1268	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FN1268	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FN1270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FN1271	COG0616	signal peptide processing
FN1277	COG2195	Cleaves the N-terminal amino acid of tripeptides
FN1280	COG1864	DNA RNA non-specific endonuclease
FN1280	COG3591	Belongs to the peptidase S1B family
FN1282	COG0203	ribosomal protein L17
FN1283	COG0202	RNA polymerase activity
FN1284	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FN1285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FN1286	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FN1287	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FN1295	COG0456	acetyltransferase
FN1298	COG0563	adenylate kinase activity
FN1301	COG0488	(ABC) transporter
FN1303	COG2096	Adenosyltransferase
FN1304	COG0629	single-stranded DNA binding
FN1306	COG2267	carboxylic ester hydrolase activity
FN1307	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FN1308	COG4589	Belongs to the CDS family
FN1311	COG0848	biopolymer transport protein
FN1312	COG0811	peptide transport
FN1313	COG4166	transmembrane transport
FN1317	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FN1318	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FN1319	COG0358	DNA primase activity
FN1321	COG2204	response regulator
FN1322	COG0750	zinc metalloprotease
FN1324	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FN1325	COG4589	Belongs to the CDS family
FN1326	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FN1329	COG0742	ribosomal rna small subunit methyltransferase
FN1330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FN1331	COG2890	protein-(glutamine-N5) methyltransferase activity
FN1332	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FN1340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FN1342	COG0736	holo-[acyl-carrier-protein] synthase activity
FN1343	COG0084	hydrolase, TatD family'
FN1348	COG1136	(ABC) transporter
FN1352	COG1136	(ABC) transporter
FN1353	COG0577	efflux transmembrane transporter activity
FN1353	COG1136	(ABC) transporter
FN1354	COG0577	efflux transmembrane transporter activity
FN1359	COG0747	negative chemotaxis
FN1361	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN1362	COG0444	Belongs to the ABC transporter superfamily
FN1363	COG4608	Belongs to the ABC transporter superfamily
FN1364	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FN1366	COG0149	triose-phosphate isomerase activity
FN1368	COG1040	competence protein
FN1370	COG0792	nuclease activity
FN1371	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FN1372	COG0564	pseudouridine synthase activity
FN1373	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FN1378	COG3052	prosthetic group binding
FN1382	COG1373	ATPase (AAA superfamily
FN1384	COG0456	acetyltransferase
FN1386	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FN1392	COG0228	four-way junction DNA binding
FN1393	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FN1394	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FN1397	COG2066	Belongs to the glutaminase family
FN1398	COG1115	amino acid carrier protein
FN1400	COG3629	intracellular signal transduction
FN1401	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FN1402	COG3314	Sporulation integral membrane protein YlbJ
FN1403	COG2056	Na+-H+ antiporter family
FN1406	COG2986	histidine ammonia-lyase
FN1408	COG2195	Cleaves the N-terminal amino acid of tripeptides
FN1411	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FN1413	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FN1415	COG1979	alcohol dehydrogenase
FN1416	COG0436	Aminotransferase
FN1418	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FN1419	COG0626	cystathionine gamma-synthase activity
FN1422	COG1757	Na H antiporter
FN1423	COG0426	domain, Protein
FN1423	COG1773	rubredoxin
FN1424	COG1960	acyl-CoA dehydrogenase activity
FN1427	COG0384	phenazine biosynthesis protein PhzF
FN1429	COG0411	ABC transporter
FN1433	COG4221	oxidoreductase activity
FN1436	COG1132	(ABC) transporter
FN1437	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FN1439	COG1349	DNA-binding transcription factor activity
FN1440	COG1105	Belongs to the carbohydrate kinase PfkB family
FN1441	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FN1441	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FN1441	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FN1442	COG2801	Transposase and inactivated derivatives
FN1444	COG0519	Catalyzes the synthesis of GMP from XMP
FN1444	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FN1447	COG2801	Transposase and inactivated derivatives
FN1448	COG4804	nuclease activity
FN1450	COG2985	domain, Protein
FN1450	COG0569	domain protein
FN1451	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FN1454	COG1181	Belongs to the D-alanine--D-alanine ligase family
FN1455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FN1456	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FN1457	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FN1458	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FN1459	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FN1461	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FN1462	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FN1463	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FN1464	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FN1470	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FN1472	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FN1473	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FN1473	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FN1475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FN1476	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FN1477	COG0697	spore germination
FN1480	COG2239	Acts as a magnesium transporter
FN1481	COG0343	queuine tRNA-ribosyltransferase activity
FN1482	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FN1483	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FN1487	COG4492	Belongs to the UPF0735 family
FN1488	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FN1489	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FN1490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FN1491	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FN1491	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FN1491	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FN1492	COG1381	Involved in DNA repair and RecF pathway recombination
FN1497	COG2814	Major facilitator Superfamily
FN1501	COG0444	Belongs to the ABC transporter superfamily
FN1502	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN1503	COG0601	transmembrane transport
FN1504	COG0747	negative chemotaxis
FN1505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FN1506	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FN1506	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FN1508	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FN1508	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FN1517	COG0495	leucyl-tRNA aminoacylation
FN1518	COG1595	DNA-templated transcription, initiation
FN1519	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FN1520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FN1522	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN1523	COG0747	negative chemotaxis
FN1524	COG0444	Belongs to the ABC transporter superfamily
FN1525	COG4608	Belongs to the ABC transporter superfamily
FN1530	COG2801	Transposase and inactivated derivatives
FN1531	COG1346	cytolysis
FN1532	COG1380	Effector of murein hydrolase LrgA
FN1533	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FN1535	COG1960	acyl-CoA dehydrogenase activity
FN1536	COG0277	FAD linked oxidase domain protein
FN1537	COG0003	Pfam Anion-transporting ATPase
FN1538	COG0003	Pfam Anion-transporting ATPase
FN1539	COG1556	Lactate utilization protein
FN1540	COG1139	Iron-sulfur cluster binding protein
FN1541	COG0142	geranyltranstransferase activity
FN1544	COG0644	oxidoreductase
FN1546	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FN1547	COG1263	PTS System
FN1547	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FN1555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FN1556	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FN1557	COG0049	tRNA binding
FN1558	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FN1561	COG1496	oxidoreductase activity
FN1562	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FN1575	COG2827	Endonuclease containing a URI domain
FN1576	COG0470	DNA polymerase III
FN1578	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FN1579	COG0215	cysteine-tRNA ligase activity
FN1580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FN1581	COG1193	negative regulation of DNA recombination
FN1586	COG4948	Mandelate Racemase Muconate Lactonizing
FN1591	COG2878	Part of a membrane complex involved in electron transport
FN1591	COG1245	4Fe-4S binding domain
FN1592	COG4657	Part of a membrane complex involved in electron transport
FN1593	COG4660	Part of a membrane complex involved in electron transport
FN1594	COG4659	FMN binding
FN1595	COG4658	electron transport chain
FN1596	COG4656	Part of a membrane complex involved in electron transport
FN1597	COG0193	aminoacyl-tRNA hydrolase activity
FN1600	COG0101	tRNA pseudouridine synthase activity
FN1602	COG1683	Conserved Protein
FN1605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FN1606	COG1519	Transferase
FN1606	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FN1607	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FN1608	COG2264	protein methyltransferase activity
FN1609	COG1692	metallophosphoesterase
FN1612	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FN1613	COG2805	Type II/IV secretion system protein
FN1614	COG0606	chelatase, subunit chli
FN1615	COG1971	Probably functions as a manganese efflux pump
FN1616	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FN1620	COG0052	Belongs to the universal ribosomal protein uS2 family
FN1621	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FN1622	COG0528	UMP kinase activity
FN1623	COG0233	cytoplasmic translational termination
FN1625	COG0200	Binds to the 23S rRNA
FN1626	COG1841	ribosomal large subunit assembly
FN1627	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FN1628	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FN1629	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FN1630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FN1631	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FN1632	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FN1635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FN1636	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FN1637	COG0255	Belongs to the universal ribosomal protein uL29 family
FN1638	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FN1639	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FN1640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FN1641	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FN1642	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FN1643	COG0089	rRNA binding
FN1644	COG0088	Forms part of the polypeptide exit tunnel
FN1645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FN1646	COG0051	transcription antitermination factor activity, RNA binding
FN1648	COG4608	Belongs to the ABC transporter superfamily
FN1650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FN1651	COG0601	transmembrane transport
FN1652	COG0747	negative chemotaxis
FN1653	COG0534	Mate efflux family protein
FN1656	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FN1657	COG0360	Binds together with S18 to 16S ribosomal RNA
FN1658	COG0442	prolyl-tRNA aminoacylation
FN1660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FN1661	COG0217	transcriptional regulatory protein
FN1667	COG1088	dTDP-glucose 4,6-dehydratase activity
FN1680	COG2801	Transposase and inactivated derivatives
FN1684	COG2089	acid synthase
FN1685	COG1088	dTDP-glucose 4,6-dehydratase activity
FN1686	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
FN1687	COG1028	Short-chain dehydrogenase reductase Sdr
FN1689	COG1086	Polysaccharide biosynthesis protein
FN1692	COG1216	Glycosyl transferase, family 2
FN1698	COG1091	dTDP-4-dehydrorhamnose reductase activity
FN1702	COG1968	undecaprenyl-diphosphatase activity
FN1703	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FN1704	COG1752	Esterase of the alpha-beta hydrolase superfamily
FN1707	COG2017	converts alpha-aldose to the beta-anomer
FN1708	COG1185	polyribonucleotide nucleotidyltransferase activity
FN1709	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FN1711	COG0275	rRNA processing
FN1713	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FN1715	COG1373	ATPase (AAA superfamily
FN1717	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FN1718	COG0653	protein targeting
FN1722	COG0357	Ribosomal RNA small subunit methyltransferase G
FN1723	COG0445	tRNA wobble uridine modification
FN1724	COG0569	domain protein
FN1725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FN1726	COG0534	Mate efflux family protein
FN1728	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FN1730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FN1731	COG0512	Glutamine amidotransferase of anthranilate synthase
FN1733	COG1394	ATPase activity, coupled to movement of substances
FN1734	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FN1737	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
FN1738	COG1527	subunit (C
FN1739	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
FN1740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FN1741	COG1269	ATP hydrolysis coupled proton transport
FN1747	COG1115	amino acid carrier protein
FN1752	COG0352	thiamine-phosphate diphosphorylase activity
FN1754	COG2022	thiamine diphosphate biosynthetic process
FN1755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FN1757	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FN1758	COG0352	thiamine-phosphate diphosphorylase activity
FN1762	COG3022	response to hydroperoxide
FN1764	COG0148	phosphopyruvate hydratase activity
FN1781	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FN1781	COG1185	polyribonucleotide nucleotidyltransferase activity
FN1781	COG0539	negative regulation of cytoplasmic translation
FN1783	COG4820	ethanolamine utilization protein (EutJ)
FN1786	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FN1786	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FN1788	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FN1789	COG0534	Mate efflux family protein
FN1791	COG1051	belongs to the nudix hydrolase family
FN1793	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FN1794	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FN1797	COG3842	ATPase activity
FN1798	COG1176	ABC-type spermidine putrescine transport system, permease component I
FN1799	COG1177	transmembrane transport
FN1801	COG0786	glutamate:sodium symporter activity
FN1803	COG1309	transcriptional regulator
FN1804	COG2195	Cleaves the N-terminal amino acid of tripeptides
FN1811	COG1121	(ABC) transporter
FN1813	COG0803	Belongs to the bacterial solute-binding protein 9 family
FN1817	COG3210	domain, Protein
FN1817	COG3210	domain, Protein
FN1818	COG2831	hemolysin activation secretion protein
FN1819	COG4988	ABC transporter
FN1820	COG1132	(ABC) transporter
FN1826	COG0826	peptidase U32
FN1827	COG0305	Participates in initiation and elongation during chromosome replication
FN1828	COG0359	binds to the 23S rRNA
FN1830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FN1831	COG2204	response regulator
FN1833	COG0848	biopolymer transport protein
FN1834	COG0811	peptide transport
FN1838	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FN1839	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FN1840	COG2376	Dihydroxyacetone kinase
FN1847	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FN1850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FN1851	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FN1853	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FN1855	COG4865	methylaspartate mutase activity
FN1857	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FN1858	COG2031	fatty acid transporter
FN1860	COG1757	Na H antiporter
FN1862	COG5012	cobalamin binding
FN1863	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FN1866	COG1509	lysine 2,3-aminomutase activity
FN1867	COG0604	alcohol dehydrogenase
FN1868	COG3246	L-lysine catabolic process to acetate
FN1869	COG1607	acyl-coa hydrolase
FN1873	COG0537	adenosine 5'-monophosphoramidase activity
FN1874	COG0698	ribose 5-phosphate isomerase
FN1876	COG0504	CTP synthase activity
FN1877	COG2252	PERMEase
FN1879	COG0268	Binds directly to 16S ribosomal RNA
FN1885	COG1272	protein, Hemolysin III
FN1891	COG0584	glycerophosphoryl diester phosphodiesterase
FN1894	COG2992	FlgJ-related protein
FN1898	COG1129	ABC transporter
FN1903	COG0446	pyridine nucleotide-disulphide oxidoreductase
FN1904	COG1733	regulation of RNA biosynthetic process
FN1906	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FN1907	COG1739	Uncharacterized protein family UPF0029
FN1908	COG0584	glycerophosphoryl diester phosphodiesterase
FN1909	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FN1911	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FN1913	COG1418	mRNA catabolic process
FN1917	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FN1918	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FN1919	COG2226	methyltransferase
FN1920	COG0482	sulfurtransferase activity
FN1924	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FN1925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FN1926	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FN1926	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FN1926	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FN1927	COG1461	Dihydroxyacetone kinase
FN1929	COG1058	Belongs to the CinA family
FN1929	COG1546	Belongs to the CinA family
FN1930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FN1931	COG0826	peptidase U32
FN1932	COG0237	dephospho-CoA kinase activity
FN1940	COG0534	Mate efflux family protein
FN1941	COG0542	response to heat
FN1942	COG2964	Protein conserved in bacteria
FN1944	COG0733	neurotransmitter:sodium symporter activity
FN1949	COG0006	proline dipeptidase activity
FN1951	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FN1953	COG1115	amino acid carrier protein
FN1968	COG1120	ATPase activity
FN1969	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FN1971	COG4206	TonB-dependent receptor
FN1973	COG0251	oxidation-reduction process
FN1975	COG0513	Belongs to the DEAD box helicase family
FN1976	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FN1977	COG0037	tRNA processing
FN1978	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FN1979	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FN1983	COG0450	alkyl hydroperoxide reductase
FN1985	COG4452	Inner membrane protein CreD
FN1987	COG1802	Transcriptional regulator
FN1988	COG3033	Beta-eliminating lyase
FN1989	COG0733	neurotransmitter:sodium symporter activity
FN1991	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FN1992	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FN1993	COG0009	L-threonylcarbamoyladenylate synthase
FN1996	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FN2003	COG1268	BioY protein
FN2004	COG1122	ATPase activity
FN2005	COG1122	ATPase activity
FN2006	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FN2008	COG1125	glycine betaine transport
FN2009	COG1174	glycine betaine transport
FN2011	COG0525	valine-tRNA ligase activity
FN2013	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FN2014	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FN2015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FN2016	COG0740	serine-type endopeptidase activity
FN2017	COG0544	peptidyl-prolyl cis-trans isomerase activity
FN2018	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FN2018	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FN2019	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FN2020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FN2022	COG0195	Participates in both transcription termination and antitermination
FN2023	COG0779	Required for maturation of 30S ribosomal subunits
FN2029	COG2755	lipolytic protein G-D-S-L family
FN2029	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FN2030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FN2033	COG0194	GDP metabolic process
FN2034	COG1561	YicC-like family, N-terminal region
FN2035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FN2036	COG0085	RNA polymerase activity
FN2037	COG0222	ribosome binding
FN2038	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FN2039	COG0081	regulation of translation
FN2040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FN2041	COG0250	Participates in transcription elongation, termination and antitermination
FN2044	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FN2045	COG0735	belongs to the Fur family
FN2053	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FN2054	COG0166	Belongs to the GPI family
FN2067	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FN2068	COG1078	dGTPase activity
FN2069	COG1115	amino acid carrier protein
FN2070	COG1492	cobalamin metabolic process
FN2073	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FN2077	COG1757	Na H antiporter
FN2079	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FN2080	COG4120	Belongs to the binding-protein-dependent transport system permease family
FN2082	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FN2086	COG1450	Type ii and iii secretion system protein
FN2094	COG1459	type II secretion system
FN2095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FN2099	COG2832	Protein of unknown function (DUF454)
FN2101	COG0697	spore germination
FN2102	COG0488	(ABC) transporter
FN2103	COG3181	Tripartite tricarboxylate transporter family receptor
FN2106	COG1288	antiporter activity
FN2107	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FN2108	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FN2109	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FN2122	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FN2122	COG0072	phenylalanine-tRNA ligase activity
FN2123	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FN2125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FN2126	COG0187	DNA topoisomerase II activity
FN2128	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP