locus-tag	class	description
CBG61_RS00005	COG3451	type IV secretory pathway VirB4
CBG61_RS00035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBG61_RS00055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CBG61_RS00065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CBG61_RS00070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CBG61_RS00080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CBG61_RS00085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CBG61_RS00090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBG61_RS00095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CBG61_RS00100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBG61_RS00115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBG61_RS00125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBG61_RS00130	COG0456	acetyltransferase
CBG61_RS00135	COG0681	Belongs to the peptidase S26 family
CBG61_RS00140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBG61_RS00140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBG61_RS00145	COG1840	ABC-type Fe3 transport system, periplasmic component
CBG61_RS00150	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CBG61_RS00155	COG1840	ABC-type Fe3 transport system, periplasmic component
CBG61_RS00160	COG3842	ATPase activity
CBG61_RS00165	COG1176	ABC-type spermidine putrescine transport system, permease component I
CBG61_RS00170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CBG61_RS00185	COG0561	phosphatase activity
CBG61_RS00195	COG0726	polysaccharide deacetylase
CBG61_RS00220	COG0601	transmembrane transport
CBG61_RS00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBG61_RS00230	COG0444	Belongs to the ABC transporter superfamily
CBG61_RS00235	COG4608	Belongs to the ABC transporter superfamily
CBG61_RS00275	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBG61_RS00285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CBG61_RS00290	COG2890	protein-(glutamine-N5) methyltransferase activity
CBG61_RS00295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CBG61_RS00300	COG0742	ribosomal rna small subunit methyltransferase
CBG61_RS00315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CBG61_RS00320	COG4589	Belongs to the CDS family
CBG61_RS00325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CBG61_RS00340	COG0750	zinc metalloprotease
CBG61_RS00345	COG2204	response regulator
CBG61_RS00355	COG0358	DNA primase activity
CBG61_RS00360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBG61_RS00365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBG61_RS00385	COG4166	transmembrane transport
CBG61_RS00395	COG0848	biopolymer transport protein
CBG61_RS00410	COG4589	Belongs to the CDS family
CBG61_RS00415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBG61_RS00420	COG2267	carboxylic ester hydrolase activity
CBG61_RS00430	COG0629	single-stranded DNA binding
CBG61_RS00435	COG2096	Adenosyltransferase
CBG61_RS00445	COG0488	(ABC) transporter
CBG61_RS00455	COG0563	adenylate kinase activity
CBG61_RS00510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CBG61_RS00520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CBG61_RS00525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CBG61_RS00530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBG61_RS00535	COG0202	RNA polymerase activity
CBG61_RS00540	COG0203	ribosomal protein L17
CBG61_RS00560	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBG61_RS00590	COG0616	signal peptide processing
CBG61_RS00595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBG61_RS00605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBG61_RS00605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBG61_RS00620	COG2885	chlorophyll binding
CBG61_RS00645	COG5002	protein histidine kinase activity
CBG61_RS00645	COG3850	Histidine kinase
CBG61_RS00650	COG1573	uracil-dna glycosylase
CBG61_RS00655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CBG61_RS00665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CBG61_RS00675	COG0778	Nitroreductase
CBG61_RS00690	COG0672	)-iron permease
CBG61_RS00695	COG2252	PERMEase
CBG61_RS00705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBG61_RS00760	COG1621	beta-fructofuranosidase activity
CBG61_RS00765	COG1263	PTS System
CBG61_RS00765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBG61_RS00765	COG2190	(PTS) system
CBG61_RS00775	COG0516	GMP reductase activity
CBG61_RS00775	COG0517	IMP dehydrogenase activity
CBG61_RS00795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CBG61_RS00805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CBG61_RS00810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CBG61_RS00875	COG4399	Belongs to the UPF0754 family
CBG61_RS00880	COG2255	four-way junction helicase activity
CBG61_RS00890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CBG61_RS00895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBG61_RS00910	COG0768	penicillin binding
CBG61_RS00915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CBG61_RS00920	COG1534	Rna-binding protein
CBG61_RS00925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBG61_RS00935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CBG61_RS00940	COG0793	Belongs to the peptidase S41A family
CBG61_RS00945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBG61_RS00950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CBG61_RS00955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBG61_RS00970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBG61_RS00985	COG0326	Molecular chaperone. Has ATPase activity
CBG61_RS01025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBG61_RS01040	COG0601	transmembrane transport
CBG61_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBG61_RS01050	COG0444	Belongs to the ABC transporter superfamily
CBG61_RS01055	COG4608	Belongs to the ABC transporter superfamily
CBG61_RS01060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBG61_RS01100	COG1518	maintenance of DNA repeat elements
CBG61_RS01105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CBG61_RS01110	COG0280	phosphate acetyltransferase
CBG61_RS01115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CBG61_RS01120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBG61_RS01120	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBG61_RS01120	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBG61_RS01120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CBG61_RS01125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CBG61_RS01135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CBG61_RS01150	COG0039	L-malate dehydrogenase activity
CBG61_RS01160	COG4211	Belongs to the binding-protein-dependent transport system permease family
CBG61_RS01165	COG1129	ABC transporter
CBG61_RS01175	COG1940	carbohydrate kinase activity
CBG61_RS01190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBG61_RS01195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBG61_RS01205	COG1494	fructose-1,6-bisphosphatase
CBG61_RS01215	COG0242	peptide deformylase activity
CBG61_RS01220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBG61_RS01225	COG0768	penicillin binding
CBG61_RS01230	COG1295	ribonuclease BN
CBG61_RS01240	COG0436	Aminotransferase
CBG61_RS01245	COG0534	Mate efflux family protein
CBG61_RS01265	COG3681	Belongs to the UPF0597 family
CBG61_RS01285	COG0363	glucosamine-6-phosphate deaminase activity
CBG61_RS01290	COG1242	4 iron, 4 sulfur cluster binding
CBG61_RS01295	COG2116	formate transmembrane transporter activity
CBG61_RS01315	COG3639	organic phosphonate transmembrane transporter activity
CBG61_RS01320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CBG61_RS01325	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CBG61_RS01340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CBG61_RS01355	COG1196	nuclear chromosome segregation
CBG61_RS01365	COG1506	peptidase
CBG61_RS01365	COG0823	Involved in the tonB-independent uptake of proteins
CBG61_RS01365	COG4946	Tricorn protease homolog
CBG61_RS01375	COG1704	LemA family
CBG61_RS01390	COG0326	Molecular chaperone. Has ATPase activity
CBG61_RS01395	COG0318	PFAM AMP-dependent synthetase and ligase
CBG61_RS01400	COG4868	Belongs to the UPF0371 family
CBG61_RS01405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CBG61_RS01410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CBG61_RS01420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CBG61_RS01435	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CBG61_RS01455	COG1760	l-serine dehydratase
CBG61_RS01465	COG0632	four-way junction helicase activity
CBG61_RS01475	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CBG61_RS01530	COG3872	metal-dependent enzyme
CBG61_RS01535	COG2208	phosphoserine phosphatase activity
CBG61_RS01540	COG0322	excinuclease ABC activity
CBG61_RS01545	COG1660	Displays ATPase and GTPase activities
CBG61_RS01550	COG0446	pyridine nucleotide-disulphide oxidoreductase
CBG61_RS01560	COG1335	isochorismatase
CBG61_RS01585	COG1132	(ABC) transporter
CBG61_RS01615	COG0552	protein localization to endoplasmic reticulum
CBG61_RS01625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CBG61_RS01635	COG4974	Belongs to the 'phage' integrase family
CBG61_RS01640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CBG61_RS01645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBG61_RS01650	COG0758	DNA mediated transformation
CBG61_RS01660	COG1570	exodeoxyribonuclease VII activity
CBG61_RS01675	COG1473	amidohydrolase
CBG61_RS01685	COG4884	unkown
CBG61_RS01685	COG3831	ATPase activity
CBG61_RS01690	COG1114	Component of the transport system for branched-chain amino acids
CBG61_RS01705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBG61_RS01745	COG0346	lactoylglutathione lyase activity
CBG61_RS01805	COG1733	regulation of RNA biosynthetic process
CBG61_RS01815	COG2996	Protein conserved in bacteria
CBG61_RS01835	COG1687	branched-chain amino acid
CBG61_RS01840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CBG61_RS01850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CBG61_RS01865	COG1116	anion transmembrane transporter activity
CBG61_RS01910	COG0612	Peptidase, M16
CBG61_RS01915	COG0756	dUTP diphosphatase activity
CBG61_RS01920	COG0772	Belongs to the SEDS family
CBG61_RS01930	COG2252	PERMEase
CBG61_RS01935	COG0776	regulation of translation
CBG61_RS01945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBG61_RS01955	COG1024	Enoyl-CoA hydratase
CBG61_RS01960	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBG61_RS01975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CBG61_RS01990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CBG61_RS01995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBG61_RS02035	COG1032	radical SAM domain protein
CBG61_RS02040	COG1032	radical SAM domain protein
CBG61_RS02045	COG1032	radical SAM domain protein
CBG61_RS02085	COG1032	radical SAM domain protein
CBG61_RS02090	COG0531	amino acid
CBG61_RS02095	COG0076	glutamate decarboxylase activity
CBG61_RS02115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CBG61_RS02120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CBG61_RS02125	COG1363	Peptidase, m42
CBG61_RS02130	COG0747	negative chemotaxis
CBG61_RS02140	COG5522	Integral membrane protein (intg_mem_TP0381)
CBG61_RS02145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBG61_RS02155	COG1183	phosphatidylcholine synthase activity
CBG61_RS02160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBG61_RS02165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBG61_RS02170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBG61_RS02175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CBG61_RS02180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CBG61_RS02185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CBG61_RS02195	COG0138	bifunctional purine biosynthesis protein purh
CBG61_RS02205	COG0151	Belongs to the GarS family
CBG61_RS02215	COG1757	Na H antiporter
CBG61_RS02220	COG1492	cobalamin metabolic process
CBG61_RS02240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBG61_RS02245	COG1797	cobyrinic acid a,c-diamide synthase activity
CBG61_RS02275	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CBG61_RS02285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBG61_RS02295	COG1373	ATPase (AAA superfamily
CBG61_RS02395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CBG61_RS02440	COG0534	Mate efflux family protein
CBG61_RS02450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CBG61_RS02470	COG0494	nUDIX hydrolase
CBG61_RS02475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CBG61_RS02475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CBG61_RS02480	COG0802	atpase or kinase
CBG61_RS02485	COG1214	PFAM Peptidase M22, glycoprotease
CBG61_RS02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBG61_RS02530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBG61_RS02540	COG0501	Belongs to the peptidase M48B family
CBG61_RS02555	COG2190	(PTS) system
CBG61_RS02570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CBG61_RS02575	COG0406	alpha-ribazole phosphatase activity
CBG61_RS02580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CBG61_RS02585	COG2003	Belongs to the UPF0758 family
CBG61_RS02590	COG1774	PSP1 C-terminal conserved region
CBG61_RS02595	COG2890	protein-(glutamine-N5) methyltransferase activity
CBG61_RS02600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CBG61_RS02630	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CBG61_RS02635	COG0517	IMP dehydrogenase activity
CBG61_RS02635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CBG61_RS02640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CBG61_RS02650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CBG61_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
CBG61_RS02670	COG2315	Protein conserved in bacteria
CBG61_RS02685	COG1373	ATPase (AAA superfamily
CBG61_RS02730	COG1854	S-ribosylhomocysteine lyase activity
CBG61_RS02735	COG1164	Oligoendopeptidase f
CBG61_RS02740	COG4206	TonB-dependent receptor
CBG61_RS02750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBG61_RS02755	COG1120	ATPase activity
CBG61_RS02760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG61_RS02765	COG0494	nUDIX hydrolase
CBG61_RS02770	COG0616	signal peptide processing
CBG61_RS02785	COG0248	Ppx GppA phosphatase
CBG61_RS02785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBG61_RS02790	COG1054	Belongs to the UPF0176 family
CBG61_RS02795	COG0561	phosphatase activity
CBG61_RS02800	COG0037	tRNA processing
CBG61_RS02805	COG0318	PFAM AMP-dependent synthetase and ligase
CBG61_RS02810	COG0670	Belongs to the BI1 family
CBG61_RS02825	COG0058	SHG alpha-glucan phosphorylase activity
CBG61_RS02830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CBG61_RS02835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CBG61_RS02840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CBG61_RS02845	COG0297	glycogen (starch) synthase activity
CBG61_RS02855	COG4106	trans-aconitate 2-methyltransferase activity
CBG61_RS02970	COG0577	efflux transmembrane transporter activity
CBG61_RS02975	COG1136	(ABC) transporter
CBG61_RS02980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CBG61_RS02995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBG61_RS03000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CBG61_RS03010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBG61_RS03025	COG0776	regulation of translation
CBG61_RS03045	COG0406	alpha-ribazole phosphatase activity
CBG61_RS03050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CBG61_RS03055	COG2385	sporulation resulting in formation of a cellular spore
CBG61_RS03065	COG1122	ATPase activity
CBG61_RS03080	COG0310	cobalt ion transport
CBG61_RS03085	COG0785	Cytochrome C biogenesis protein
CBG61_RS03095	COG0765	amino acid transport
CBG61_RS03100	COG1126	abc transporter atp-binding protein
CBG61_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBG61_RS03115	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CBG61_RS03125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBG61_RS03125	COG0574	Belongs to the PEP-utilizing enzyme family
CBG61_RS03130	COG0517	IMP dehydrogenase activity
CBG61_RS03145	COG0786	glutamate:sodium symporter activity
CBG61_RS03150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CBG61_RS03155	COG2986	histidine ammonia-lyase
CBG61_RS03160	COG1940	carbohydrate kinase activity
CBG61_RS03165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBG61_RS03175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBG61_RS03180	COG2086	electron transfer activity
CBG61_RS03185	COG1960	acyl-CoA dehydrogenase activity
CBG61_RS03205	COG0523	cobalamin synthesis protein
CBG61_RS03215	COG0481	GTPase activity
CBG61_RS03220	COG2502	aspartate--ammonia ligase
CBG61_RS03225	COG1362	aminopeptidase activity
CBG61_RS03245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBG61_RS03250	COG1120	ATPase activity
CBG61_RS03255	COG4139	cobalamin transport
CBG61_RS03260	COG4206	TonB-dependent receptor
CBG61_RS03265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBG61_RS03270	COG1970	mechanosensitive ion channel activity
CBG61_RS03275	COG0482	sulfurtransferase activity
CBG61_RS03290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CBG61_RS03300	COG0424	maF-like protein
CBG61_RS03305	COG1077	Cell shape determining protein MreB Mrl
CBG61_RS03310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CBG61_RS03315	COG1187	pseudouridine synthase activity
CBG61_RS03320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBG61_RS03325	COG0154	amidase activity
CBG61_RS03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBG61_RS03345	COG0252	asparaginase activity
CBG61_RS03370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CBG61_RS03375	COG1480	7TM receptor with intracellular HD hydrolase
CBG61_RS03385	COG1199	ATP-dependent helicase activity
CBG61_RS03390	COG4807	Protein conserved in bacteria
CBG61_RS03400	COG1228	amidohydrolase
CBG61_RS03410	COG3404	Formiminotransferase-cyclodeaminase
CBG61_RS03435	COG0527	aspartate kinase activity
CBG61_RS03440	COG0460	homoserine dehydrogenase
CBG61_RS03475	COG1032	radical SAM domain protein
CBG61_RS03480	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBG61_RS03490	COG1323	Belongs to the UPF0348 family
CBG61_RS03500	COG0588	phosphoglycerate mutase activity
CBG61_RS03525	COG3177	Filamentation induced by cAMP protein fic
CBG61_RS03530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CBG61_RS03535	COG0716	FMN binding
CBG61_RS03545	COG0747	negative chemotaxis
CBG61_RS03565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBG61_RS03580	COG1187	pseudouridine synthase activity
CBG61_RS03610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBG61_RS03620	COG0728	peptidoglycan biosynthetic process
CBG61_RS03630	COG0196	riboflavin kinase activity
CBG61_RS03640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBG61_RS03640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBG61_RS03645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CBG61_RS03645	COG4797	methyltransferase
CBG61_RS03650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBG61_RS03655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBG61_RS03660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CBG61_RS03665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBG61_RS03670	COG1137	ATPase activity
CBG61_RS03680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBG61_RS03725	COG4145	pantothenate transmembrane transporter activity
CBG61_RS03730	COG1151	hydroxylamine reductase activity
CBG61_RS03750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CBG61_RS03760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBG61_RS03765	COG1162	GTPase activity
CBG61_RS03800	COG4120	Belongs to the binding-protein-dependent transport system permease family
CBG61_RS03805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CBG61_RS03810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CBG61_RS03815	COG1373	ATPase (AAA superfamily
CBG61_RS03830	COG0701	Predicted permease
CBG61_RS03845	COG4974	Belongs to the 'phage' integrase family
CBG61_RS03850	COG3177	Filamentation induced by cAMP protein fic
CBG61_RS03890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBG61_RS03895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBG61_RS03900	COG1121	(ABC) transporter
CBG61_RS03905	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBG61_RS03915	COG0534	Mate efflux family protein
CBG61_RS03935	COG0010	Belongs to the arginase family
CBG61_RS03945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CBG61_RS03950	COG2011	ABC-type metal ion transport system permease component
CBG61_RS03975	COG0126	phosphoglycerate kinase activity
CBG61_RS03985	COG0564	pseudouridine synthase activity
CBG61_RS03990	COG1757	Na H antiporter
CBG61_RS03995	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CBG61_RS04010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CBG61_RS04015	COG0181	hydroxymethylbilane synthase activity
CBG61_RS04020	COG0519	Catalyzes the synthesis of GMP from XMP
CBG61_RS04070	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CBG61_RS04095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBG61_RS04125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CBG61_RS04130	COG1217	gtp-binding protein TYPA
CBG61_RS04140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CBG61_RS04155	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CBG61_RS04160	COG0427	acetyl-CoA hydrolase
CBG61_RS04165	COG0668	transmembrane transport
CBG61_RS04175	COG0592	DNA-directed DNA polymerase activity
CBG61_RS04185	COG1733	regulation of RNA biosynthetic process
CBG61_RS04190	COG1902	pentaerythritol trinitrate reductase activity
CBG61_RS04195	COG1132	(ABC) transporter
CBG61_RS04200	COG2375	cellular response to nickel ion
CBG61_RS04200	COG1132	(ABC) transporter
CBG61_RS04205	COG0426	domain, Protein
CBG61_RS04220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBG61_RS04230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CBG61_RS04235	COG0557	exoribonuclease II activity
CBG61_RS04245	COG1713	HD superfamily hydrolase involved in NAD metabolism
CBG61_RS04310	COG1132	(ABC) transporter
CBG61_RS04315	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG61_RS04325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG61_RS04330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBG61_RS04360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBG61_RS04365	COG1733	regulation of RNA biosynthetic process
CBG61_RS04370	COG2910	NAD(P)H-binding
CBG61_RS04380	COG5002	protein histidine kinase activity
CBG61_RS04395	COG1136	(ABC) transporter
CBG61_RS04405	COG4953	penicillin-binding protein 1C
CBG61_RS04415	COG0514	ATP-dependent DNA helicase (RecQ)
CBG61_RS04445	COG2304	oxidoreductase activity
CBG61_RS04450	COG0758	DNA mediated transformation
CBG61_RS04455	COG0482	sulfurtransferase activity
CBG61_RS04460	COG1799	cell septum assembly
CBG61_RS04465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBG61_RS04470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBG61_RS04475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBG61_RS04505	COG1473	amidohydrolase
CBG61_RS04525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBG61_RS04530	COG2137	regulation of response to DNA damage stimulus
CBG61_RS04535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CBG61_RS04540	COG0859	PFAM glycosyl transferase family 9
CBG61_RS04550	COG0859	PFAM glycosyl transferase family 9
CBG61_RS04560	COG0463	Glycosyl transferase, family 2
CBG61_RS04565	COG0726	polysaccharide deacetylase
CBG61_RS04570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBG61_RS04575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CBG61_RS04575	COG1648	precorrin-2 dehydrogenase activity
CBG61_RS04585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBG61_RS04610	COG1278	Cold shock
CBG61_RS04625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CBG61_RS04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBG61_RS04635	COG0210	DNA helicase
CBG61_RS04645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG61_RS04650	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CBG61_RS04670	COG1959	2 iron, 2 sulfur cluster binding
CBG61_RS04700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CBG61_RS04715	COG0426	domain, Protein
CBG61_RS04720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBG61_RS04725	COG4667	esterase of the alpha-beta hydrolase superfamily
CBG61_RS04735	COG0018	arginyl-trna synthetase
CBG61_RS04740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CBG61_RS04750	COG0583	DNA-binding transcription factor activity
CBG61_RS04755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CBG61_RS04775	COG1982	Orn Lys Arg decarboxylase major
CBG61_RS04780	COG3033	Beta-eliminating lyase
CBG61_RS04785	COG2342	PFAM TM1410 hypothetical-related protein
CBG61_RS04805	COG0183	Belongs to the thiolase family
CBG61_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
CBG61_RS04840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBG61_RS04850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBG61_RS04860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBG61_RS04870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CBG61_RS04875	COG0254	rRNA binding
CBG61_RS04895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CBG61_RS04900	COG0739	heme binding
CBG61_RS04905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CBG61_RS04910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBG61_RS04920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CBG61_RS04930	COG1346	cytolysis
CBG61_RS04940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CBG61_RS04955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CBG61_RS04960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBG61_RS04965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CBG61_RS04970	COG0113	porphobilinogen synthase activity
CBG61_RS04995	COG1592	Rubrerythrin
CBG61_RS05015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CBG61_RS05135	COG2003	Belongs to the UPF0758 family
CBG61_RS05240	COG4962	Type ii secretion system protein e
CBG61_RS05250	COG3451	type IV secretory pathway VirB4
CBG61_RS05275	COG0582	viral genome integration into host DNA
CBG61_RS05295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CBG61_RS05300	COG1914	H( )-stimulated, divalent metal cation uptake system
CBG61_RS05305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CBG61_RS05310	COG1984	allophanate hydrolase subunit 2
CBG61_RS05315	COG0813	purine-nucleoside phosphorylase activity
CBG61_RS05320	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBG61_RS05345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBG61_RS05350	COG0335	large ribosomal subunit rRNA binding
CBG61_RS05360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBG61_RS05365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CBG61_RS05375	COG0284	orotidine-5'-phosphate decarboxylase activity
CBG61_RS05390	COG0167	dihydroorotate dehydrogenase activity
CBG61_RS05395	COG0543	2 iron, 2 sulfur cluster binding
CBG61_RS05400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBG61_RS05405	COG0505	Belongs to the CarA family
CBG61_RS05410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CBG61_RS05420	COG0540	Belongs to the ATCase OTCase family
CBG61_RS05425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBG61_RS05485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CBG61_RS05490	COG2926	Belongs to the UPF0265 family
CBG61_RS05495	COG0205	6-phosphofructokinase activity
CBG61_RS05500	COG0825	malonyl-CoA metabolic process
CBG61_RS05505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CBG61_RS05515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBG61_RS05520	COG0180	Tryptophanyl-tRNA synthetase
CBG61_RS05525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBG61_RS05550	COG0736	holo-[acyl-carrier-protein] synthase activity
CBG61_RS05555	COG0084	hydrolase, TatD family'
CBG61_RS05650	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CBG61_RS05685	COG1136	(ABC) transporter
CBG61_RS05705	COG1136	(ABC) transporter
CBG61_RS05710	COG0577	efflux transmembrane transporter activity
CBG61_RS05710	COG1136	(ABC) transporter
CBG61_RS05715	COG0577	efflux transmembrane transporter activity
CBG61_RS05730	COG0747	negative chemotaxis
CBG61_RS05740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBG61_RS05745	COG0444	Belongs to the ABC transporter superfamily
CBG61_RS05750	COG4608	Belongs to the ABC transporter superfamily
CBG61_RS05760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CBG61_RS05770	COG0149	triose-phosphate isomerase activity
CBG61_RS05780	COG1040	competence protein
CBG61_RS05790	COG0792	nuclease activity
CBG61_RS05795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBG61_RS05800	COG0564	pseudouridine synthase activity
CBG61_RS05805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CBG61_RS05835	COG3052	prosthetic group binding
CBG61_RS05855	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CBG61_RS05860	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CBG61_RS05865	COG0714	Associated with various cellular activities
CBG61_RS05905	COG1373	ATPase (AAA superfamily
CBG61_RS05960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBG61_RS05995	COG0228	four-way junction DNA binding
CBG61_RS06000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CBG61_RS06005	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CBG61_RS06015	COG2066	Belongs to the glutaminase family
CBG61_RS06020	COG1115	amino acid carrier protein
CBG61_RS06030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CBG61_RS06035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBG61_RS06055	COG0426	domain, Protein
CBG61_RS06060	COG1960	acyl-CoA dehydrogenase activity
CBG61_RS06075	COG0384	phenazine biosynthesis protein PhzF
CBG61_RS06105	COG1373	ATPase (AAA superfamily
CBG61_RS06110	COG4221	oxidoreductase activity
CBG61_RS06125	COG1132	(ABC) transporter
CBG61_RS06130	COG1132	(ABC) transporter
CBG61_RS06135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBG61_RS06140	COG1349	DNA-binding transcription factor activity
CBG61_RS06145	COG1105	Belongs to the carbohydrate kinase PfkB family
CBG61_RS06150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CBG61_RS06150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CBG61_RS06150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBG61_RS06160	COG0519	Catalyzes the synthesis of GMP from XMP
CBG61_RS06160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CBG61_RS06170	COG0513	Belongs to the DEAD box helicase family
CBG61_RS06190	COG2985	domain, Protein
CBG61_RS06190	COG0569	domain protein
CBG61_RS06195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBG61_RS06210	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBG61_RS06215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CBG61_RS06220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBG61_RS06225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CBG61_RS06230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CBG61_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBG61_RS06240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBG61_RS06245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBG61_RS06250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CBG61_RS06265	COG0656	L-ascorbic acid biosynthetic process
CBG61_RS06275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBG61_RS06280	COG0789	Transcriptional regulator
CBG61_RS06300	COG4115	mRNA cleavage
CBG61_RS06375	COG2239	Acts as a magnesium transporter
CBG61_RS06385	COG0343	queuine tRNA-ribosyltransferase activity
CBG61_RS06390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBG61_RS06395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBG61_RS06410	COG1253	flavin adenine dinucleotide binding
CBG61_RS06415	COG4492	Belongs to the UPF0735 family
CBG61_RS06420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CBG61_RS06425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CBG61_RS06430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CBG61_RS06435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBG61_RS06435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CBG61_RS06435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CBG61_RS06440	COG1381	Involved in DNA repair and RecF pathway recombination
CBG61_RS06455	COG2814	Major facilitator Superfamily
CBG61_RS06460	COG0456	acetyltransferase
CBG61_RS06475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CBG61_RS06480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBG61_RS06480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBG61_RS06490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBG61_RS06490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBG61_RS06495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBG61_RS06500	COG1045	serine acetyltransferase
CBG61_RS06505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CBG61_RS06520	COG0495	leucyl-tRNA aminoacylation
CBG61_RS06525	COG1595	DNA-templated transcription, initiation
CBG61_RS06530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG61_RS06535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBG61_RS06540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG61_RS06550	COG0601	transmembrane transport
CBG61_RS06555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBG61_RS06560	COG0747	negative chemotaxis
CBG61_RS06575	COG1346	cytolysis
CBG61_RS06580	COG1380	Effector of murein hydrolase LrgA
CBG61_RS06585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBG61_RS06595	COG1960	acyl-CoA dehydrogenase activity
CBG61_RS06600	COG0277	FAD linked oxidase domain protein
CBG61_RS06605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBG61_RS06610	COG2190	(PTS) system
CBG61_RS06610	COG1263	PTS System
CBG61_RS06610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBG61_RS06630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CBG61_RS06635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBG61_RS06640	COG0049	tRNA binding
CBG61_RS06645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CBG61_RS06655	COG1454	alcohol dehydrogenase
CBG61_RS06660	COG3263	regulation of cellular component size
CBG61_RS06670	COG1496	oxidoreductase activity
CBG61_RS06675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBG61_RS06740	COG2827	Endonuclease containing a URI domain
CBG61_RS06745	COG0470	DNA polymerase III
CBG61_RS06755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CBG61_RS06760	COG0215	cysteine-tRNA ligase activity
CBG61_RS06765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CBG61_RS06770	COG1193	negative regulation of DNA recombination
CBG61_RS06800	COG4948	Mandelate Racemase Muconate Lactonizing
CBG61_RS06825	COG1245	4Fe-4S binding domain
CBG61_RS06825	COG2878	Part of a membrane complex involved in electron transport
CBG61_RS06830	COG4657	Part of a membrane complex involved in electron transport
CBG61_RS06835	COG4660	Part of a membrane complex involved in electron transport
CBG61_RS06840	COG4659	FMN binding
CBG61_RS06845	COG4658	electron transport chain
CBG61_RS06850	COG4656	Part of a membrane complex involved in electron transport
CBG61_RS06855	COG0193	aminoacyl-tRNA hydrolase activity
CBG61_RS06860	COG0101	tRNA pseudouridine synthase activity
CBG61_RS06870	COG4115	mRNA cleavage
CBG61_RS06880	COG0584	glycerophosphoryl diester phosphodiesterase
CBG61_RS06885	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG61_RS06895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CBG61_RS06905	COG1418	mRNA catabolic process
CBG61_RS06915	COG2172	sigma factor antagonist activity
CBG61_RS06925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CBG61_RS06930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBG61_RS06945	COG2226	methyltransferase
CBG61_RS06950	COG0482	sulfurtransferase activity
CBG61_RS06970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBG61_RS06975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBG61_RS06975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBG61_RS06975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBG61_RS06990	COG1461	Dihydroxyacetone kinase
CBG61_RS07000	COG1546	Belongs to the CinA family
CBG61_RS07000	COG1058	Belongs to the CinA family
CBG61_RS07005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CBG61_RS07010	COG0826	peptidase U32
CBG61_RS07015	COG0237	dephospho-CoA kinase activity
CBG61_RS07025	COG0542	response to heat
CBG61_RS07085	COG2964	Protein conserved in bacteria
CBG61_RS07095	COG0733	neurotransmitter:sodium symporter activity
CBG61_RS07120	COG0006	proline dipeptidase activity
CBG61_RS07125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CBG61_RS07130	COG1115	amino acid carrier protein
CBG61_RS07135	COG0584	glycerophosphoryl diester phosphodiesterase
CBG61_RS07185	COG4172	Belongs to the ABC transporter superfamily
CBG61_RS07190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBG61_RS07200	COG0747	negative chemotaxis
CBG61_RS07215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBG61_RS07225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBG61_RS07270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBG61_RS07270	COG0551	DNA topoisomerase type I activity
CBG61_RS07290	COG0741	lytic transglycosylase activity
CBG61_RS07290	COG0739	heme binding
CBG61_RS07290	COG1196	nuclear chromosome segregation
CBG61_RS07335	COG3451	type IV secretory pathway VirB4
CBG61_RS07345	COG4962	Type ii secretion system protein e
CBG61_RS07415	COG1192	Involved in chromosome partitioning
CBG61_RS07445	COG0582	viral genome integration into host DNA
CBG61_RS07460	COG3022	response to hydroperoxide
CBG61_RS07475	COG0148	phosphopyruvate hydratase activity
CBG61_RS07480	COG0469	pyruvate kinase activity
CBG61_RS07560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CBG61_RS07560	COG1185	polyribonucleotide nucleotidyltransferase activity
CBG61_RS07560	COG0539	negative regulation of cytoplasmic translation
CBG61_RS07570	COG4820	ethanolamine utilization protein (EutJ)
CBG61_RS07615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CBG61_RS07615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CBG61_RS07625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CBG61_RS07630	COG0534	Mate efflux family protein
CBG61_RS07640	COG1051	belongs to the nudix hydrolase family
CBG61_RS07650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBG61_RS07655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBG61_RS07665	COG3842	ATPase activity
CBG61_RS07670	COG1176	ABC-type spermidine putrescine transport system, permease component I
CBG61_RS07675	COG1177	transmembrane transport
CBG61_RS07685	COG0786	glutamate:sodium symporter activity
CBG61_RS07695	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBG61_RS07740	COG1121	(ABC) transporter
CBG61_RS07750	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBG61_RS07815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CBG61_RS07820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CBG61_RS07830	COG0731	radical SAM domain protein
CBG61_RS07830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBG61_RS07870	COG0443	Heat shock 70 kDa protein
CBG61_RS07885	COG1420	regulation of RNA biosynthetic process
CBG61_RS07900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CBG61_RS07910	COG1619	proteins homologs of microcin C7 resistance protein MccF
CBG61_RS07920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBG61_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBG61_RS07945	COG1598	PFAM Uncharacterised protein family UPF0150
CBG61_RS07955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CBG61_RS07960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CBG61_RS07970	COG2871	sodium ion transport
CBG61_RS07975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CBG61_RS08000	COG3118	belongs to the thioredoxin family
CBG61_RS08025	COG3192	ethanolamine utilization protein
CBG61_RS08050	COG1454	alcohol dehydrogenase
CBG61_RS08050	COG1012	belongs to the aldehyde dehydrogenase family
CBG61_RS08060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CBG61_RS08065	COG4816	utilization protein
CBG61_RS08070	COG4302	ethanolamine ammonia-lyase activity
CBG61_RS08075	COG4303	Ethanolamine ammonia lyase large subunit
CBG61_RS08095	COG0481	GTPase activity
CBG61_RS08105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CBG61_RS08110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CBG61_RS08110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CBG61_RS08115	COG0302	gtp cyclohydrolase
CBG61_RS08120	COG0751	glycine-tRNA ligase activity
CBG61_RS08130	COG0752	glycyl-tRNA synthetase alpha subunit
CBG61_RS08135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBG61_RS08140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CBG61_RS08145	COG2205	protein histidine kinase activity
CBG61_RS08150	COG2183	response to ionizing radiation
CBG61_RS08195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CBG61_RS08205	COG0822	iron-sulfur transferase activity
CBG61_RS08210	COG1104	cysteine desulfurase activity
CBG61_RS08215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBG61_RS08225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CBG61_RS08230	COG1114	Component of the transport system for branched-chain amino acids
CBG61_RS08235	COG1393	Belongs to the ArsC family
CBG61_RS08240	COG1053	succinate dehydrogenase
CBG61_RS08250	COG0647	UMP catabolic process
CBG61_RS08260	COG0708	Exodeoxyribonuclease III
CBG61_RS08265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CBG61_RS08270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CBG61_RS08285	COG0772	Belongs to the SEDS family
CBG61_RS08295	COG0017	Asparaginyl-tRNA synthetase
CBG61_RS08300	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CBG61_RS08375	COG0129	dihydroxy-acid dehydratase activity
CBG61_RS08380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CBG61_RS08390	COG0028	Belongs to the TPP enzyme family
CBG61_RS08395	COG0440	acetolactate synthase activity
CBG61_RS08405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CBG61_RS08415	COG0066	3-isopropylmalate dehydratase activity
CBG61_RS08420	COG0473	3-isopropylmalate dehydrogenase activity
CBG61_RS08425	COG1119	ATPase activity
CBG61_RS08435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CBG61_RS08525	COG1288	antiporter activity
CBG61_RS08530	COG2088	sporulation resulting in formation of a cellular spore
CBG61_RS08535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CBG61_RS08540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CBG61_RS08545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBG61_RS08575	COG0563	adenylate kinase activity
CBG61_RS08580	COG2226	methyltransferase
CBG61_RS08595	COG1733	regulation of RNA biosynthetic process
CBG61_RS08600	COG1827	regulation of RNA biosynthetic process
CBG61_RS08605	COG0157	Belongs to the NadC ModD family
CBG61_RS08615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CBG61_RS08625	COG0445	tRNA wobble uridine modification
CBG61_RS08635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBG61_RS08640	COG1847	R3H domain protein
CBG61_RS08645	COG0706	membrane insertase activity
CBG61_RS08650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CBG61_RS08655	COG0594	ribonuclease P activity
CBG61_RS08675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG61_RS08685	COG0187	DNA topoisomerase II activity
CBG61_RS08690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBG61_RS08700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CBG61_RS08705	COG0072	phenylalanine-tRNA ligase activity
CBG61_RS08705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBG61_RS08720	COG1115	amino acid carrier protein
CBG61_RS08725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CBG61_RS08730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CBG61_RS08735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CBG61_RS08740	COG1288	antiporter activity
CBG61_RS08760	COG3181	Tripartite tricarboxylate transporter family receptor
CBG61_RS08770	COG0488	(ABC) transporter
CBG61_RS08785	COG0697	spore germination
CBG61_RS08795	COG2832	Protein of unknown function (DUF454)
CBG61_RS08820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CBG61_RS08825	COG1459	type II secretion system
CBG61_RS08830	COG4969	Belongs to the N-Me-Phe pilin family
CBG61_RS08865	COG1450	Type ii and iii secretion system protein
CBG61_RS08890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CBG61_RS08905	COG4120	Belongs to the binding-protein-dependent transport system permease family
CBG61_RS08910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CBG61_RS08920	COG1757	Na H antiporter
CBG61_RS08925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBG61_RS08935	COG1492	cobalamin metabolic process
CBG61_RS08940	COG1115	amino acid carrier protein
CBG61_RS08955	COG1078	dGTPase activity
CBG61_RS08960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG61_RS08990	COG0166	Belongs to the GPI family
CBG61_RS08995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CBG61_RS09005	COG0735	belongs to the Fur family
CBG61_RS09015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CBG61_RS09030	COG0250	Participates in transcription elongation, termination and antitermination
CBG61_RS09035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CBG61_RS09040	COG0081	regulation of translation
CBG61_RS09045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CBG61_RS09050	COG0222	ribosome binding
CBG61_RS09055	COG0085	RNA polymerase activity
CBG61_RS09060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CBG61_RS09065	COG1561	YicC-like family, N-terminal region
CBG61_RS09070	COG0194	GDP metabolic process
CBG61_RS09085	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CBG61_RS09120	COG0779	Required for maturation of 30S ribosomal subunits
CBG61_RS09125	COG0195	Participates in both transcription termination and antitermination
CBG61_RS09135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CBG61_RS09140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CBG61_RS09145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBG61_RS09145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBG61_RS09150	COG0544	peptidyl-prolyl cis-trans isomerase activity
CBG61_RS09155	COG0740	serine-type endopeptidase activity
CBG61_RS09160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CBG61_RS09165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CBG61_RS09170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CBG61_RS09200	COG0525	valine-tRNA ligase activity
CBG61_RS09225	COG1174	glycine betaine transport
CBG61_RS09230	COG1125	glycine betaine transport
CBG61_RS09250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CBG61_RS09255	COG1122	ATPase activity
CBG61_RS09260	COG1122	ATPase activity
CBG61_RS09265	COG1268	BioY protein
CBG61_RS09300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CBG61_RS09315	COG0009	L-threonylcarbamoyladenylate synthase
CBG61_RS09320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBG61_RS09325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CBG61_RS09335	COG0733	neurotransmitter:sodium symporter activity
CBG61_RS09340	COG3033	Beta-eliminating lyase
CBG61_RS09345	COG1802	Transcriptional regulator
CBG61_RS09355	COG4452	Inner membrane protein CreD
CBG61_RS09380	COG0450	alkyl hydroperoxide reductase
CBG61_RS09405	COG2885	chlorophyll binding
CBG61_RS09425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CBG61_RS09430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBG61_RS09435	COG0037	tRNA processing
CBG61_RS09445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CBG61_RS09450	COG0513	Belongs to the DEAD box helicase family
CBG61_RS09480	COG0251	oxidation-reduction process
CBG61_RS09485	COG2378	regulation of single-species biofilm formation
CBG61_RS09495	COG4206	TonB-dependent receptor
CBG61_RS09510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBG61_RS09515	COG1120	ATPase activity
CBG61_RS09620	COG0352	thiamine-phosphate diphosphorylase activity
CBG61_RS09625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CBG61_RS09635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CBG61_RS09640	COG2022	thiamine diphosphate biosynthetic process
CBG61_RS09650	COG0352	thiamine-phosphate diphosphorylase activity
CBG61_RS09660	COG1269	ATP hydrolysis coupled proton transport
CBG61_RS09665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBG61_RS09670	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CBG61_RS09675	COG1527	subunit (C
CBG61_RS09680	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CBG61_RS09690	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CBG61_RS09695	COG1394	ATPase activity, coupled to movement of substances
CBG61_RS09715	COG0512	Glutamine amidotransferase of anthranilate synthase
CBG61_RS09725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBG61_RS09730	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CBG61_RS09740	COG0534	Mate efflux family protein
CBG61_RS09745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBG61_RS09750	COG0569	domain protein
CBG61_RS09755	COG0445	tRNA wobble uridine modification
CBG61_RS09760	COG0357	Ribosomal RNA small subunit methyltransferase G
CBG61_RS09770	COG0653	protein targeting
CBG61_RS09775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBG61_RS09805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBG61_RS09815	COG0275	rRNA processing
CBG61_RS09825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBG61_RS09830	COG1185	polyribonucleotide nucleotidyltransferase activity
CBG61_RS09840	COG0730	response to heat
CBG61_RS09845	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBG61_RS09850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBG61_RS09855	COG1968	undecaprenyl-diphosphatase activity
CBG61_RS09860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CBG61_RS09865	COG1091	dTDP-4-dehydrorhamnose reductase activity
CBG61_RS09875	COG1086	Polysaccharide biosynthesis protein
CBG61_RS09880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBG61_RS09890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBG61_RS09920	COG0438	transferase activity, transferring glycosyl groups
CBG61_RS09930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CBG61_RS09930	COG0463	Glycosyl transferase, family 2
CBG61_RS09935	COG4750	Nucleotidyl transferase
CBG61_RS09940	COG1696	Membrane protein involved in D-alanine export
CBG61_RS09955	COG1088	dTDP-glucose 4,6-dehydratase activity
CBG61_RS10025	COG0217	transcriptional regulatory protein
CBG61_RS10030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBG61_RS10045	COG0442	prolyl-tRNA aminoacylation
CBG61_RS10050	COG0360	Binds together with S18 to 16S ribosomal RNA
CBG61_RS10055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CBG61_RS10060	COG0501	Belongs to the peptidase M48B family
CBG61_RS10075	COG0534	Mate efflux family protein
CBG61_RS10080	COG0051	transcription antitermination factor activity, RNA binding
CBG61_RS10085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CBG61_RS10090	COG0088	Forms part of the polypeptide exit tunnel
CBG61_RS10095	COG0089	rRNA binding
CBG61_RS10100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CBG61_RS10105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CBG61_RS10110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CBG61_RS10115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CBG61_RS10120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CBG61_RS10125	COG0255	Belongs to the universal ribosomal protein uL29 family
CBG61_RS10130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CBG61_RS10135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CBG61_RS10145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CBG61_RS10150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CBG61_RS10155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CBG61_RS10160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CBG61_RS10165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CBG61_RS10170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CBG61_RS10175	COG1841	ribosomal large subunit assembly
CBG61_RS10180	COG0200	Binds to the 23S rRNA
CBG61_RS10215	COG0233	cytoplasmic translational termination
CBG61_RS10220	COG0528	UMP kinase activity
CBG61_RS10225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBG61_RS10230	COG0052	Belongs to the universal ribosomal protein uS2 family
CBG61_RS10250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBG61_RS10280	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CBG61_RS10290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG61_RS10305	COG1971	Probably functions as a manganese efflux pump
CBG61_RS10310	COG0606	chelatase, subunit chli
CBG61_RS10315	COG2805	Type II/IV secretion system protein
CBG61_RS10320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBG61_RS10330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CBG61_RS10340	COG1692	metallophosphoesterase
CBG61_RS10345	COG2264	protein methyltransferase activity
CBG61_RS10350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CBG61_RS10355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBG61_RS10355	COG1519	Transferase
CBG61_RS10360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CBG61_RS10380	COG1739	Uncharacterized protein family UPF0029
CBG61_RS10385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBG61_RS10405	COG1733	regulation of RNA biosynthetic process
CBG61_RS10450	COG1129	ABC transporter
CBG61_RS10470	COG2992	FlgJ-related protein
CBG61_RS10475	COG0584	glycerophosphoryl diester phosphodiesterase
CBG61_RS10505	COG0268	Binds directly to 16S ribosomal RNA
CBG61_RS10515	COG0504	CTP synthase activity
CBG61_RS10525	COG0698	ribose 5-phosphate isomerase
CBG61_RS10530	COG0537	adenosine 5'-monophosphoramidase activity
CBG61_RS10560	COG1607	acyl-coa hydrolase
CBG61_RS10565	COG3246	L-lysine catabolic process to acetate
CBG61_RS10570	COG0604	alcohol dehydrogenase
CBG61_RS10580	COG1509	lysine 2,3-aminomutase activity
CBG61_RS10590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBG61_RS10595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBG61_RS10600	COG5012	cobalamin binding
CBG61_RS10610	COG1757	Na H antiporter
CBG61_RS10620	COG2031	fatty acid transporter
CBG61_RS10625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CBG61_RS10635	COG4865	methylaspartate mutase activity
CBG61_RS10645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBG61_RS10655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CBG61_RS10660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBG61_RS10680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBG61_RS10700	COG4221	oxidoreductase activity
CBG61_RS10725	COG2376	Dihydroxyacetone kinase
CBG61_RS10730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CBG61_RS10735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CBG61_RS10760	COG4869	propanediol catabolic process
CBG61_RS10815	COG0745	RESPONSE REGULATOR receiver
CBG61_RS10840	COG0811	peptide transport
CBG61_RS10845	COG0848	biopolymer transport protein
CBG61_RS10855	COG2204	response regulator
CBG61_RS10860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBG61_RS10870	COG0359	binds to the 23S rRNA
CBG61_RS10875	COG0305	Participates in initiation and elongation during chromosome replication
CBG61_RS10880	COG0826	peptidase U32
CBG61_RS10915	COG1132	(ABC) transporter
CBG61_RS10920	COG4988	ABC transporter
CBG61_RS11010	COG0416	fatty acid biosynthetic process
CBG61_RS11015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBG61_RS11020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CBG61_RS11025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBG61_RS11030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBG61_RS11035	COG0571	ribonuclease III activity
CBG61_RS11040	COG1242	4 iron, 4 sulfur cluster binding
CBG61_RS11045	COG1530	ribonuclease E activity
CBG61_RS11055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CBG61_RS11060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBG61_RS11065	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CBG61_RS11075	COG0534	Mate efflux family protein
CBG61_RS11080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CBG61_RS11090	COG3023	N-Acetylmuramoyl-L-alanine amidase
CBG61_RS11165	COG1160	GTP binding
CBG61_RS11190	COG0850	regulation of cytokinetic process
CBG61_RS11195	COG2894	cell division
CBG61_RS11200	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CBG61_RS11215	COG0579	oxidoreductase
CBG61_RS11235	COG0785	Cytochrome C biogenesis protein
CBG61_RS11240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG61_RS11245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBG61_RS11245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBG61_RS11255	COG2972	Histidine kinase
CBG61_RS11270	COG0511	ligase activity, forming carbon-carbon bonds
CBG61_RS11270	COG5016	pyruvate
CBG61_RS11275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CBG61_RS11280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CBG61_RS11285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CBG61_RS11290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBG61_RS11295	COG0786	glutamate:sodium symporter activity
CBG61_RS11300	COG1924	4 iron, 4 sulfur cluster binding
CBG61_RS11305	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CBG61_RS11310	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CBG61_RS11390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CBG61_RS11395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CBG61_RS11400	COG1285	pathogenesis
CBG61_RS11405	COG4221	oxidoreductase activity
CBG61_RS11415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CBG61_RS11420	COG3279	Response regulator of the LytR AlgR family
CBG61_RS11425	COG3275	phosphorelay sensor kinase activity
CBG61_RS11430	COG1966	Carbon starvation protein
CBG61_RS11435	COG2211	Major facilitator Superfamily
CBG61_RS11440	COG2333	competence protein COMEC
CBG61_RS11440	COG0658	competence protein
CBG61_RS11445	COG0556	nucleotide-excision repair
CBG61_RS11450	COG2610	gluconate transmembrane transporter activity
CBG61_RS11455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CBG61_RS11460	COG3395	kinase activity
CBG61_RS11465	COG1349	DNA-binding transcription factor activity
CBG61_RS11485	COG1116	anion transmembrane transporter activity
CBG61_RS11490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CBG61_RS11495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CBG61_RS11540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CBG61_RS11550	COG0569	domain protein
CBG61_RS11555	COG0617	tRNA 3'-terminal CCA addition
CBG61_RS11580	COG2217	Heavy metal translocating P-type atpase
CBG61_RS11630	COG1288	antiporter activity
CBG61_RS11645	COG2217	Heavy metal translocating P-type atpase
CBG61_RS11655	COG0640	Transcriptional regulator
CBG61_RS11660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CBG61_RS11690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CBG61_RS11695	COG0497	DNA recombination
CBG61_RS11700	COG4974	Belongs to the 'phage' integrase family
CBG61_RS11705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CBG61_RS11715	COG0765	amino acid transport
CBG61_RS11720	COG4215	(ABC) transporter
CBG61_RS11730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBG61_RS11755	COG0626	cystathionine gamma-synthase activity
CBG61_RS11760	COG1283	sodium-dependent phosphate transmembrane transporter activity
CBG61_RS11770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBG61_RS11775	COG2853	Lipoprotein
CBG61_RS11790	COG4752	Belongs to the RNA methyltransferase TrmD family
CBG61_RS11795	COG0336	Belongs to the RNA methyltransferase TrmD family
CBG61_RS11800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CBG61_RS11805	COG1837	Belongs to the UPF0109 family
CBG61_RS11815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CBG61_RS11820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CBG61_RS11890	COG3959	Transketolase, thiamine diphosphate binding domain
CBG61_RS11895	COG3958	Transketolase
CBG61_RS11905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CBG61_RS11910	COG0124	histidyl-tRNA synthetase
CBG61_RS11915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CBG61_RS11920	COG0747	negative chemotaxis
CBG61_RS11925	COG0601	transmembrane transport
CBG61_RS11950	COG1120	ATPase activity
CBG61_RS11960	COG1176	ABC-type spermidine putrescine transport system, permease component I
CBG61_RS11965	COG3842	ATPase activity
CBG61_RS11970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CBG61_RS11970	COG1328	CTP reductase activity
CBG61_RS11980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBG61_RS11980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBG61_RS11990	COG2207	Transcriptional regulator
CBG61_RS11990	COG3708	Transcriptional regulator
CBG61_RS12000	COG0133	tryptophan synthase activity
CBG61_RS12015	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CBG61_RS12020	COG0583	DNA-binding transcription factor activity
CBG61_RS12030	COG3052	prosthetic group binding
CBG61_RS12040	COG3051	citrate lyase alpha subunit
CBG61_RS12050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CBG61_RS12060	COG0326	Molecular chaperone. Has ATPase activity
CBG61_RS12065	COG3588	fructose-bisphosphate aldolase
CBG61_RS12090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CBG61_RS12095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CBG61_RS12100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CBG61_RS12105	COG1115	amino acid carrier protein
CBG61_RS12110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CBG61_RS12115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CBG61_RS12125	COG0598	Magnesium transport protein CorA
CBG61_RS12130	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CBG61_RS12160	COG2056	Na+-H+ antiporter family
CBG61_RS12165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBG61_RS12175	COG0116	Belongs to the methyltransferase superfamily
CBG61_RS12190	COG0688	phosphatidylethanolamine metabolic process
CBG61_RS12195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CBG61_RS12200	COG1490	D-aminoacyl-tRNA deacylase activity
CBG61_RS12215	COG1757	Na H antiporter
CBG61_RS12245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBG61_RS12250	COG2003	Belongs to the UPF0758 family
CBG61_RS12300	COG1192	Involved in chromosome partitioning
CBG61_RS12340	COG0582	viral genome integration into host DNA
CBG61_RS12415	COG4962	Type ii secretion system protein e