locus-tag	class	description
HMPREF0405_RS00325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF0405_RS00345	COG0751	glycine-tRNA ligase activity
HMPREF0405_RS00350	COG0751	glycine-tRNA ligase activity
HMPREF0405_RS00390	COG4303	Ethanolamine ammonia lyase large subunit
HMPREF0405_RS00640	COG0733	neurotransmitter:sodium symporter activity
HMPREF0405_RS01035	COG1619	proteins homologs of microcin C7 resistance protein MccF
HMPREF0405_RS01055	COG1420	regulation of RNA biosynthetic process
HMPREF0405_RS01070	COG0443	Heat shock 70 kDa protein
HMPREF0405_RS01645	COG0442	prolyl-tRNA aminoacylation
HMPREF0405_RS01650	COG0442	prolyl-tRNA aminoacylation
HMPREF0405_RS01655	COG0442	prolyl-tRNA aminoacylation
HMPREF0405_RS01715	COG0534	Mate efflux family protein
HMPREF0405_RS01855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF0405_RS02070	COG0747	negative chemotaxis
HMPREF0405_RS02280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF0405_RS02570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0405_RS02975	COG0116	Belongs to the methyltransferase superfamily
HMPREF0405_RS03180	COG0726	polysaccharide deacetylase
HMPREF0405_RS03290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0405_RS03575	COG2121	Domain of unknown function (DUF374)
HMPREF0405_RS03790	COG2255	four-way junction helicase activity
HMPREF0405_RS04315	COG1196	nuclear chromosome segregation
HMPREF0405_RS04465	COG2208	phosphoserine phosphatase activity
HMPREF0405_RS04525	COG0552	protein localization to endoplasmic reticulum
HMPREF0405_RS04565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0405_RS04570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0405_RS04775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0405_RS04805	COG0285	dihydrofolate synthase activity
HMPREF0405_RS04905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF0405_RS04930	COG0138	bifunctional purine biosynthesis protein purh
HMPREF0405_RS04940	COG0151	Belongs to the GarS family
HMPREF0405_RS04975	COG1492	cobalamin metabolic process
HMPREF0405_RS05340	COG4206	TonB-dependent receptor
HMPREF0405_RS05740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF0405_RS06320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0405_RS06320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0405_RS06595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF0405_RS06770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF0405_RS06785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0405_RS07155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMPREF0405_RS07670	COG0540	Belongs to the ATCase OTCase family
HMPREF0405_RS07700	COG0825	malonyl-CoA metabolic process
HMPREF0405_RS08015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF0405_RS08035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF0405_RS08055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF0405_RS08980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMPREF0405_RS09135	COG0534	Mate efflux family protein
HMPREF0405_RS09400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF0405_RS09590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0405_RS09870	COG1086	Polysaccharide biosynthesis protein