locus-tag	class	description
CTM64_RS00010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTM64_RS00035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTM64_RS00035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTM64_RS00055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTM64_RS00060	COG1045	serine acetyltransferase
CTM64_RS00090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTM64_RS00110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM64_RS00125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTM64_RS00130	COG0254	rRNA binding
CTM64_RS00150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTM64_RS00155	COG0739	heme binding
CTM64_RS00160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTM64_RS00165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM64_RS00175	COG0203	ribosomal protein L17
CTM64_RS00180	COG0202	RNA polymerase activity
CTM64_RS00185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTM64_RS00190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTM64_RS00195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTM64_RS00205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTM64_RS00245	COG1278	Cold shock
CTM64_RS00250	COG1621	beta-fructofuranosidase activity
CTM64_RS00390	COG2369	cell adhesion
CTM64_RS00400	COG1783	phage Terminase large subunit
CTM64_RS00415	COG0602	queuosine metabolic process
CTM64_RS00420	COG0720	synthase
CTM64_RS00425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CTM64_RS00435	COG1475	DNA binding
CTM64_RS00480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTM64_RS00510	COG0629	single-stranded DNA binding
CTM64_RS00560	COG0582	viral genome integration into host DNA
CTM64_RS00565	COG0517	IMP dehydrogenase activity
CTM64_RS00565	COG0516	GMP reductase activity
CTM64_RS00585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CTM64_RS00590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTM64_RS00595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CTM64_RS00600	COG3153	acetyltransferase
CTM64_RS00600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTM64_RS00670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CTM64_RS00680	COG0569	domain protein
CTM64_RS00685	COG0617	tRNA 3'-terminal CCA addition
CTM64_RS00690	COG1196	nuclear chromosome segregation
CTM64_RS00705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTM64_RS00710	COG1115	amino acid carrier protein
CTM64_RS00725	COG4589	Belongs to the CDS family
CTM64_RS00730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTM64_RS00735	COG2267	carboxylic ester hydrolase activity
CTM64_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTM64_RS00765	COG0481	GTPase activity
CTM64_RS00785	COG2966	Psort location CytoplasmicMembrane, score
CTM64_RS00790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTM64_RS00795	COG1960	acyl-CoA dehydrogenase activity
CTM64_RS00800	COG2086	electron transfer activity
CTM64_RS00805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTM64_RS00815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTM64_RS00820	COG1940	carbohydrate kinase activity
CTM64_RS00820	COG1846	Transcriptional regulator
CTM64_RS00825	COG2986	histidine ammonia-lyase
CTM64_RS00830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CTM64_RS00845	COG4608	Belongs to the ABC transporter superfamily
CTM64_RS00850	COG0601	transmembrane transport
CTM64_RS00855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS00865	COG0747	negative chemotaxis
CTM64_RS00895	COG0460	homoserine dehydrogenase
CTM64_RS00900	COG0527	aspartate kinase activity
CTM64_RS00925	COG1132	(ABC) transporter
CTM64_RS00930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM64_RS00940	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM64_RS00945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTM64_RS00955	COG0210	DNA helicase
CTM64_RS01000	COG5002	protein histidine kinase activity
CTM64_RS01005	COG0745	RESPONSE REGULATOR receiver
CTM64_RS01010	COG1136	(ABC) transporter
CTM64_RS01020	COG4953	penicillin-binding protein 1C
CTM64_RS01045	COG0514	ATP-dependent DNA helicase (RecQ)
CTM64_RS01065	COG1598	PFAM Uncharacterised protein family UPF0150
CTM64_RS01085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CTM64_RS01115	COG0745	RESPONSE REGULATOR receiver
CTM64_RS01120	COG3850	Histidine kinase
CTM64_RS01120	COG5002	protein histidine kinase activity
CTM64_RS01125	COG1573	uracil-dna glycosylase
CTM64_RS01130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM64_RS01140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM64_RS01150	COG0647	UMP catabolic process
CTM64_RS01155	COG0778	Nitroreductase
CTM64_RS01170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CTM64_RS01175	COG1914	H( )-stimulated, divalent metal cation uptake system
CTM64_RS01180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CTM64_RS01185	COG1984	allophanate hydrolase subunit 2
CTM64_RS01195	COG0561	phosphatase activity
CTM64_RS01205	COG0726	polysaccharide deacetylase
CTM64_RS01225	COG0697	spore germination
CTM64_RS01245	COG0110	maltose O-acetyltransferase activity
CTM64_RS01265	COG1132	(ABC) transporter
CTM64_RS01270	COG1132	(ABC) transporter
CTM64_RS01305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTM64_RS01325	COG1464	Belongs to the NlpA lipoprotein family
CTM64_RS01330	COG2011	ABC-type metal ion transport system permease component
CTM64_RS01335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTM64_RS01340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTM64_RS01345	COG0786	glutamate:sodium symporter activity
CTM64_RS01355	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CTM64_RS01455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM64_RS01465	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CTM64_RS01505	COG3177	Filamentation induced by cAMP protein fic
CTM64_RS01510	COG1797	cobyrinic acid a,c-diamide synthase activity
CTM64_RS01515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTM64_RS01545	COG0602	queuosine metabolic process
CTM64_RS01550	COG1328	CTP reductase activity
CTM64_RS01550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTM64_RS01555	COG3842	ATPase activity
CTM64_RS01560	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTM64_RS01610	COG1120	ATPase activity
CTM64_RS01615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM64_RS01625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CTM64_RS01630	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CTM64_RS01640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM64_RS01645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTM64_RS01665	COG0601	transmembrane transport
CTM64_RS01670	COG0747	negative chemotaxis
CTM64_RS01675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTM64_RS01680	COG0124	histidyl-tRNA synthetase
CTM64_RS01705	COG3958	Transketolase
CTM64_RS01710	COG3959	Transketolase, thiamine diphosphate binding domain
CTM64_RS01725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTM64_RS01735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTM64_RS01745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTM64_RS01750	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTM64_RS01755	COG0280	phosphate acetyltransferase
CTM64_RS01795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CTM64_RS01800	COG1648	precorrin-2 dehydrogenase activity
CTM64_RS01800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CTM64_RS01810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CTM64_RS01815	COG0540	Belongs to the ATCase OTCase family
CTM64_RS01820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTM64_RS01825	COG0505	Belongs to the CarA family
CTM64_RS01830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTM64_RS01840	COG0543	2 iron, 2 sulfur cluster binding
CTM64_RS01845	COG0167	dihydroorotate dehydrogenase activity
CTM64_RS01875	COG0284	orotidine-5'-phosphate decarboxylase activity
CTM64_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CTM64_RS01890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTM64_RS01905	COG0405	Gamma-glutamyltransferase
CTM64_RS01925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTM64_RS01940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTM64_RS01945	COG0736	holo-[acyl-carrier-protein] synthase activity
CTM64_RS01950	COG0084	hydrolase, TatD family'
CTM64_RS01980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTM64_RS01985	COG4589	Belongs to the CDS family
CTM64_RS01990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTM64_RS02000	COG0750	zinc metalloprotease
CTM64_RS02015	COG0358	DNA primase activity
CTM64_RS02020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM64_RS02025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM64_RS02055	COG1132	(ABC) transporter
CTM64_RS02060	COG4988	ABC transporter
CTM64_RS02065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CTM64_RS02070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTM64_RS02110	COG1136	(ABC) transporter
CTM64_RS02115	COG0577	efflux transmembrane transporter activity
CTM64_RS02215	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CTM64_RS02220	COG0494	nUDIX hydrolase
CTM64_RS02225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CTM64_RS02225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CTM64_RS02230	COG0802	atpase or kinase
CTM64_RS02235	COG1214	PFAM Peptidase M22, glycoprotease
CTM64_RS02260	COG2315	Protein conserved in bacteria
CTM64_RS02280	COG4221	oxidoreductase activity
CTM64_RS02285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CTM64_RS02305	COG0517	IMP dehydrogenase activity
CTM64_RS02305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTM64_RS02310	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CTM64_RS02330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTM64_RS02340	COG1024	Enoyl-CoA hydratase
CTM64_RS02345	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTM64_RS02350	COG0482	sulfurtransferase activity
CTM64_RS02355	COG1799	cell septum assembly
CTM64_RS02360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTM64_RS02365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM64_RS02370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM64_RS02500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTM64_RS02515	COG0534	Mate efflux family protein
CTM64_RS02540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CTM64_RS02545	COG0716	FMN binding
CTM64_RS02575	COG2255	four-way junction helicase activity
CTM64_RS02585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTM64_RS02590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM64_RS02605	COG0768	penicillin binding
CTM64_RS02610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CTM64_RS02615	COG1534	Rna-binding protein
CTM64_RS02620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTM64_RS02630	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTM64_RS02635	COG0793	Belongs to the peptidase S41A family
CTM64_RS02635	COG3409	Peptidoglycan-binding domain 1 protein
CTM64_RS02640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTM64_RS02645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTM64_RS02650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTM64_RS02665	COG1862	Preprotein translocase
CTM64_RS02680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTM64_RS02685	COG2890	protein-(glutamine-N5) methyltransferase activity
CTM64_RS02690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTM64_RS02695	COG0742	ribosomal rna small subunit methyltransferase
CTM64_RS02700	COG1722	exodeoxyribonuclease VII activity
CTM64_RS02725	COG4120	Belongs to the binding-protein-dependent transport system permease family
CTM64_RS02730	COG1116	anion transmembrane transporter activity
CTM64_RS02730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTM64_RS02740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTM64_RS02740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTM64_RS02755	COG2116	formate transmembrane transporter activity
CTM64_RS02760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTM64_RS02765	COG1373	ATPase (AAA superfamily
CTM64_RS02775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTM64_RS02780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTM64_RS02785	COG1121	(ABC) transporter
CTM64_RS02790	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTM64_RS02795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CTM64_RS02805	COG0534	Mate efflux family protein
CTM64_RS02810	COG0436	Aminotransferase
CTM64_RS02820	COG1295	ribonuclease BN
CTM64_RS02825	COG0768	penicillin binding
CTM64_RS02830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTM64_RS02835	COG0242	peptide deformylase activity
CTM64_RS02845	COG1494	fructose-1,6-bisphosphatase
CTM64_RS02875	COG0484	heat shock protein binding
CTM64_RS02900	COG0454	-acetyltransferase
CTM64_RS02905	COG0133	tryptophan synthase activity
CTM64_RS02930	COG1757	Na H antiporter
CTM64_RS02940	COG1242	4 iron, 4 sulfur cluster binding
CTM64_RS02945	COG0363	glucosamine-6-phosphate deaminase activity
CTM64_RS02950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CTM64_RS02955	COG1687	branched-chain amino acid
CTM64_RS02975	COG2996	Protein conserved in bacteria
CTM64_RS03035	COG0346	lactoylglutathione lyase activity
CTM64_RS03085	COG1114	Component of the transport system for branched-chain amino acids
CTM64_RS03095	COG3831	ATPase activity
CTM64_RS03095	COG4884	unkown
CTM64_RS03100	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTM64_RS03105	COG0557	exoribonuclease II activity
CTM64_RS03110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTM64_RS03120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTM64_RS03150	COG0424	maF-like protein
CTM64_RS03155	COG1077	Cell shape determining protein MreB Mrl
CTM64_RS03160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTM64_RS03165	COG1187	pseudouridine synthase activity
CTM64_RS03170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTM64_RS03175	COG0154	amidase activity
CTM64_RS03180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTM64_RS03190	COG0252	asparaginase activity
CTM64_RS03205	COG0658	competence protein
CTM64_RS03205	COG2333	competence protein COMEC
CTM64_RS03225	COG1882	Formate acetyltransferase
CTM64_RS03250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTM64_RS03255	COG0497	DNA recombination
CTM64_RS03260	COG4974	Belongs to the 'phage' integrase family
CTM64_RS03265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTM64_RS03275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTM64_RS03280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTM64_RS03285	COG1116	anion transmembrane transporter activity
CTM64_RS03290	COG0629	single-stranded DNA binding
CTM64_RS03300	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM64_RS03310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTM64_RS03325	COG1164	Oligoendopeptidase f
CTM64_RS03485	COG4974	Belongs to the 'phage' integrase family
CTM64_RS03490	COG1335	isochorismatase
CTM64_RS03495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CTM64_RS03500	COG0181	hydroxymethylbilane synthase activity
CTM64_RS03550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CTM64_RS03555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CTM64_RS03560	COG3639	organic phosphonate transmembrane transporter activity
CTM64_RS03580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CTM64_RS03585	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CTM64_RS03600	COG0151	Belongs to the GarS family
CTM64_RS03620	COG0138	bifunctional purine biosynthesis protein purh
CTM64_RS03625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTM64_RS03630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTM64_RS03635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTM64_RS03640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTM64_RS03645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTM64_RS03650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTM64_RS03655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CTM64_RS03660	COG0556	nucleotide-excision repair
CTM64_RS03665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTM64_RS03675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM64_RS03675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM64_RS03725	COG4106	trans-aconitate 2-methyltransferase activity
CTM64_RS03735	COG0494	nUDIX hydrolase
CTM64_RS03745	COG0210	DNA helicase
CTM64_RS03750	COG1362	aminopeptidase activity
CTM64_RS03755	COG2502	aspartate--ammonia ligase
CTM64_RS03785	COG0747	negative chemotaxis
CTM64_RS03790	COG0668	transmembrane transport
CTM64_RS03810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTM64_RS03815	COG0534	Mate efflux family protein
CTM64_RS03820	COG0776	regulation of translation
CTM64_RS03835	COG1492	cobalamin metabolic process
CTM64_RS03860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM64_RS03865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM64_RS03865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CTM64_RS03870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CTM64_RS03875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM64_RS03895	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CTM64_RS03900	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CTM64_RS03905	COG1924	4 iron, 4 sulfur cluster binding
CTM64_RS03910	COG0786	glutamate:sodium symporter activity
CTM64_RS03915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTM64_RS03920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTM64_RS03925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTM64_RS03930	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CTM64_RS03935	COG5016	pyruvate
CTM64_RS03935	COG0511	ligase activity, forming carbon-carbon bonds
CTM64_RS03950	COG0534	Mate efflux family protein
CTM64_RS03955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTM64_RS04000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTM64_RS04005	COG4206	TonB-dependent receptor
CTM64_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM64_RS04015	COG4604	ABC transporter, ATP-binding protein
CTM64_RS04020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM64_RS04035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTM64_RS04045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTM64_RS04050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CTM64_RS04060	COG4868	Belongs to the UPF0371 family
CTM64_RS04065	COG1022	Amp-dependent synthetase and ligase
CTM64_RS04070	COG1363	Peptidase, m42
CTM64_RS04075	COG0747	negative chemotaxis
CTM64_RS04080	COG1854	S-ribosylhomocysteine lyase activity
CTM64_RS04265	COG0740	serine-type endopeptidase activity
CTM64_RS04310	COG4115	mRNA cleavage
CTM64_RS04330	COG3561	AntA/AntB antirepressor
CTM64_RS04440	COG1192	Involved in chromosome partitioning
CTM64_RS04470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTM64_RS04485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTM64_RS04490	COG1217	gtp-binding protein TYPA
CTM64_RS04530	COG3177	Filamentation induced by cAMP protein fic
CTM64_RS04535	COG0588	phosphoglycerate mutase activity
CTM64_RS04545	COG1323	Belongs to the UPF0348 family
CTM64_RS04565	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM64_RS04570	COG1032	radical SAM domain protein
CTM64_RS04580	COG2211	Major facilitator Superfamily
CTM64_RS04600	COG0552	protein localization to endoplasmic reticulum
CTM64_RS04610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTM64_RS04615	COG4974	Belongs to the 'phage' integrase family
CTM64_RS04620	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CTM64_RS04630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTM64_RS04635	COG0758	DNA mediated transformation
CTM64_RS04645	COG1570	exodeoxyribonuclease VII activity
CTM64_RS04695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM64_RS04735	COG4974	Belongs to the 'phage' integrase family
CTM64_RS04770	COG3561	AntA/AntB antirepressor
CTM64_RS04790	COG5377	YqaJ viral recombinase family
CTM64_RS04800	COG3723	Recombinational DNA repair protein, rece pathway
CTM64_RS04815	COG1484	DNA-dependent DNA replication
CTM64_RS04850	COG4626	Terminase
CTM64_RS04850	COG1802	Transcriptional regulator
CTM64_RS04860	COG0740	serine-type endopeptidase activity
CTM64_RS04930	COG3299	homolog of phage Mu protein gp47
CTM64_RS05030	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CTM64_RS05040	COG0601	transmembrane transport
CTM64_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS05050	COG0747	negative chemotaxis
CTM64_RS05055	COG0444	Belongs to the ABC transporter superfamily
CTM64_RS05070	COG1228	amidohydrolase
CTM64_RS05080	COG3404	Formiminotransferase-cyclodeaminase
CTM64_RS05110	COG1309	transcriptional regulator
CTM64_RS05125	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CTM64_RS05130	COG0427	acetyl-CoA hydrolase
CTM64_RS05140	COG1966	Carbon starvation protein
CTM64_RS05145	COG3275	phosphorelay sensor kinase activity
CTM64_RS05150	COG3279	Response regulator of the LytR AlgR family
CTM64_RS05155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CTM64_RS05165	COG4221	oxidoreductase activity
CTM64_RS05170	COG1285	pathogenesis
CTM64_RS05175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTM64_RS05180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CTM64_RS05190	COG1704	LemA family
CTM64_RS05200	COG0823	Involved in the tonB-independent uptake of proteins
CTM64_RS05200	COG4946	Tricorn protease homolog
CTM64_RS05200	COG1506	peptidase
CTM64_RS05205	COG0765	amino acid transport
CTM64_RS05210	COG4215	(ABC) transporter
CTM64_RS05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTM64_RS05225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTM64_RS05230	COG1480	7TM receptor with intracellular HD hydrolase
CTM64_RS05235	COG1199	ATP-dependent helicase activity
CTM64_RS05240	COG4807	Protein conserved in bacteria
CTM64_RS05250	COG0297	glycogen (starch) synthase activity
CTM64_RS05255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTM64_RS05260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTM64_RS05265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTM64_RS05270	COG0058	SHG alpha-glucan phosphorylase activity
CTM64_RS05300	COG0037	tRNA processing
CTM64_RS05305	COG0561	phosphatase activity
CTM64_RS05310	COG1054	Belongs to the UPF0176 family
CTM64_RS05315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTM64_RS05315	COG0248	Ppx GppA phosphatase
CTM64_RS05320	COG1120	ATPase activity
CTM64_RS05325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM64_RS05335	COG4206	TonB-dependent receptor
CTM64_RS05345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CTM64_RS05355	COG4555	ABC transporter
CTM64_RS05370	COG0616	signal peptide processing
CTM64_RS05385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CTM64_RS05390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTM64_RS05395	COG0776	regulation of translation
CTM64_RS05400	COG2252	PERMEase
CTM64_RS05405	COG0564	pseudouridine synthase activity
CTM64_RS05410	COG0772	Belongs to the SEDS family
CTM64_RS05415	COG0756	dUTP diphosphatase activity
CTM64_RS05420	COG0612	Peptidase, M16
CTM64_RS05445	COG4608	Belongs to the ABC transporter superfamily
CTM64_RS05450	COG0444	Belongs to the ABC transporter superfamily
CTM64_RS05455	COG0747	negative chemotaxis
CTM64_RS05460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS05465	COG0601	transmembrane transport
CTM64_RS05470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM64_RS05480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM64_RS05485	COG0584	glycerophosphoryl diester phosphodiesterase
CTM64_RS05490	COG0598	Magnesium transport protein CorA
CTM64_RS05495	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CTM64_RS05525	COG1129	ABC transporter
CTM64_RS05545	COG0492	ferredoxin-NADP+ reductase activity
CTM64_RS05550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTM64_RS05555	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTM64_RS05560	COG1660	Displays ATPase and GTPase activities
CTM64_RS05565	COG0322	excinuclease ABC activity
CTM64_RS05575	COG3872	metal-dependent enzyme
CTM64_RS05590	COG0488	(ABC) transporter
CTM64_RS05600	COG0563	adenylate kinase activity
CTM64_RS05605	COG0024	Methionine aminopeptidase
CTM64_RS05610	COG2217	Heavy metal translocating P-type atpase
CTM64_RS05620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM64_RS05620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM64_RS05630	COG0196	riboflavin kinase activity
CTM64_RS05640	COG0728	peptidoglycan biosynthetic process
CTM64_RS05685	COG1187	pseudouridine synthase activity
CTM64_RS05700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTM64_RS05710	COG0416	fatty acid biosynthetic process
CTM64_RS05715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTM64_RS05720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTM64_RS05725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTM64_RS05730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTM64_RS05735	COG0571	ribonuclease III activity
CTM64_RS05740	COG1242	4 iron, 4 sulfur cluster binding
CTM64_RS05745	COG1530	ribonuclease E activity
CTM64_RS05750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTM64_RS05755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTM64_RS05760	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTM64_RS05775	COG0183	Belongs to the thiolase family
CTM64_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
CTM64_RS05820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTM64_RS05825	COG0335	large ribosomal subunit rRNA binding
CTM64_RS05840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTM64_RS05845	COG2926	Belongs to the UPF0265 family
CTM64_RS05850	COG0205	6-phosphofructokinase activity
CTM64_RS05855	COG0825	malonyl-CoA metabolic process
CTM64_RS05860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CTM64_RS05875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTM64_RS05880	COG0180	Tryptophanyl-tRNA synthetase
CTM64_RS05885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTM64_RS05890	COG0217	transcriptional regulatory protein
CTM64_RS05895	COG1461	Dihydroxyacetone kinase
CTM64_RS05905	COG1546	Belongs to the CinA family
CTM64_RS05905	COG1058	Belongs to the CinA family
CTM64_RS05910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CTM64_RS05915	COG0826	peptidase U32
CTM64_RS05920	COG0237	dephospho-CoA kinase activity
CTM64_RS05945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CTM64_RS05950	COG1970	mechanosensitive ion channel activity
CTM64_RS05955	COG0482	sulfurtransferase activity
CTM64_RS05975	COG0357	Ribosomal RNA small subunit methyltransferase G
CTM64_RS05980	COG0445	tRNA wobble uridine modification
CTM64_RS05985	COG0569	domain protein
CTM64_RS05990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTM64_RS05995	COG0534	Mate efflux family protein
CTM64_RS06010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CTM64_RS06025	COG0525	valine-tRNA ligase activity
CTM64_RS06035	COG1174	glycine betaine transport
CTM64_RS06040	COG1125	glycine betaine transport
CTM64_RS06055	COG1132	(ABC) transporter
CTM64_RS06065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTM64_RS06070	COG0285	dihydrofolate synthase activity
CTM64_RS06080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CTM64_RS06085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTM64_RS06090	COG4166	transmembrane transport
CTM64_RS06100	COG4221	oxidoreductase activity
CTM64_RS06115	COG3588	fructose-bisphosphate aldolase
CTM64_RS06120	COG0326	Molecular chaperone. Has ATPase activity
CTM64_RS06130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CTM64_RS06160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTM64_RS06165	COG2137	regulation of response to DNA damage stimulus
CTM64_RS06170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTM64_RS06175	COG0859	PFAM glycosyl transferase family 9
CTM64_RS06185	COG0859	PFAM glycosyl transferase family 9
CTM64_RS06195	COG0463	Glycosyl transferase, family 2
CTM64_RS06200	COG0726	polysaccharide deacetylase
CTM64_RS06210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTM64_RS06235	COG0653	protein targeting
CTM64_RS06240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTM64_RS06245	COG0482	sulfurtransferase activity
CTM64_RS06265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM64_RS06265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM64_RS06265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM64_RS06270	COG1105	Belongs to the carbohydrate kinase PfkB family
CTM64_RS06275	COG1349	DNA-binding transcription factor activity
CTM64_RS06320	COG0582	viral genome integration into host DNA
CTM64_RS06385	COG5484	DNA packaging
CTM64_RS06385	COG3728	DNA packaging
CTM64_RS06410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTM64_RS06415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CTM64_RS06420	COG0210	DNA helicase
CTM64_RS06430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM64_RS06435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTM64_RS06470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTM64_RS06480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTM64_RS06485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTM64_RS06495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM64_RS06500	COG2217	Heavy metal translocating P-type atpase
CTM64_RS06510	COG0640	Transcriptional regulator
CTM64_RS06550	COG2831	hemolysin activation secretion protein
CTM64_RS06585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTM64_RS06590	COG2853	Lipoprotein
CTM64_RS06605	COG4752	Belongs to the RNA methyltransferase TrmD family
CTM64_RS06610	COG0336	Belongs to the RNA methyltransferase TrmD family
CTM64_RS06615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTM64_RS06620	COG1837	Belongs to the UPF0109 family
CTM64_RS06630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTM64_RS06635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTM64_RS06710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTM64_RS06715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTM64_RS06720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTM64_RS06725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTM64_RS06730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM64_RS06735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTM64_RS06740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM64_RS06770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM64_RS06780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTM64_RS06785	COG0456	acetyltransferase
CTM64_RS06810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTM64_RS06810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTM64_RS06815	COG1840	ABC-type Fe3 transport system, periplasmic component
CTM64_RS06820	COG3842	ATPase activity
CTM64_RS06830	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CTM64_RS06880	COG1288	antiporter activity
CTM64_RS06905	COG0697	spore germination
CTM64_RS06925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CTM64_RS06935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTM64_RS06940	COG1162	GTPase activity
CTM64_RS07085	COG0010	Belongs to the arginase family
CTM64_RS07090	COG1473	amidohydrolase
CTM64_RS07095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTM64_RS07100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTM64_RS07115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM64_RS07120	COG1115	amino acid carrier protein
CTM64_RS07125	COG1492	cobalamin metabolic process
CTM64_RS07135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM64_RS07240	COG0765	amino acid transport
CTM64_RS07245	COG1126	abc transporter atp-binding protein
CTM64_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTM64_RS07270	COG0733	neurotransmitter:sodium symporter activity
CTM64_RS07290	COG2056	Na+-H+ antiporter family
CTM64_RS07295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTM64_RS07305	COG0116	Belongs to the methyltransferase superfamily
CTM64_RS07320	COG0688	phosphatidylethanolamine metabolic process
CTM64_RS07325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CTM64_RS07330	COG1490	D-aminoacyl-tRNA deacylase activity
CTM64_RS07345	COG1288	antiporter activity
CTM64_RS07350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CTM64_RS07355	COG0113	porphobilinogen synthase activity
CTM64_RS07565	COG0740	serine-type endopeptidase activity
CTM64_RS07670	COG1192	Involved in chromosome partitioning
CTM64_RS07710	COG3969	phosphoadenosine phosphosulfate
CTM64_RS07715	COG1475	DNA binding
CTM64_RS07750	COG0582	viral genome integration into host DNA
CTM64_RS07760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTM64_RS07765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTM64_RS07770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTM64_RS07785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTM64_RS07795	COG1183	phosphatidylcholine synthase activity
CTM64_RS07805	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CTM64_RS07810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM64_RS07810	COG0574	Belongs to the PEP-utilizing enzyme family
CTM64_RS07815	COG0517	IMP dehydrogenase activity
CTM64_RS07835	COG0626	cystathionine gamma-synthase activity
CTM64_RS07845	COG4452	Inner membrane protein CreD
CTM64_RS07880	COG1268	BioY protein
CTM64_RS07885	COG1122	ATPase activity
CTM64_RS07890	COG1122	ATPase activity
CTM64_RS07895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTM64_RS07900	COG2264	protein methyltransferase activity
CTM64_RS07905	COG1692	metallophosphoesterase
CTM64_RS07925	COG1420	regulation of RNA biosynthetic process
CTM64_RS07935	COG0443	Heat shock 70 kDa protein
CTM64_RS07940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CTM64_RS07945	COG0484	heat shock protein binding
CTM64_RS07955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CTM64_RS07955	COG4797	methyltransferase
CTM64_RS07960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTM64_RS07965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTM64_RS07970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTM64_RS07980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTM64_RS07990	COG1137	ATPase activity
CTM64_RS08000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTM64_RS08005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTM64_RS08010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CTM64_RS08015	COG2894	cell division
CTM64_RS08020	COG0850	regulation of cytokinetic process
CTM64_RS08060	COG1160	GTP binding
CTM64_RS08080	COG0537	adenosine 5'-monophosphoramidase activity
CTM64_RS08085	COG0698	ribose 5-phosphate isomerase
CTM64_RS08100	COG2252	PERMEase
CTM64_RS08110	COG0268	Binds directly to 16S ribosomal RNA
CTM64_RS08115	COG0778	Nitroreductase
CTM64_RS08120	COG0519	Catalyzes the synthesis of GMP from XMP
CTM64_RS08120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTM64_RS08160	COG1802	Transcriptional regulator
CTM64_RS08165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM64_RS08165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CTM64_RS08175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM64_RS08185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTM64_RS08195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CTM64_RS08230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CTM64_RS08240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTM64_RS08250	COG1442	glycosyl transferase family 8
CTM64_RS08250	COG1216	Glycosyl transferase, family 2
CTM64_RS08255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CTM64_RS08265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTM64_RS08270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTM64_RS08275	COG1086	Polysaccharide biosynthesis protein
CTM64_RS08290	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CTM64_RS08295	COG1968	undecaprenyl-diphosphatase activity
CTM64_RS08300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM64_RS08305	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTM64_RS08325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM64_RS08345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTM64_RS08350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTM64_RS08355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTM64_RS08360	COG1595	DNA-templated transcription, initiation
CTM64_RS08365	COG0495	leucyl-tRNA aminoacylation
CTM64_RS08380	COG2342	PFAM TM1410 hypothetical-related protein
CTM64_RS08405	COG1802	Transcriptional regulator
CTM64_RS08410	COG3033	Beta-eliminating lyase
CTM64_RS08415	COG0733	neurotransmitter:sodium symporter activity
CTM64_RS08420	COG1394	ATPase activity, coupled to movement of substances
CTM64_RS08425	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CTM64_RS08435	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CTM64_RS08440	COG1527	subunit (C
CTM64_RS08445	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CTM64_RS08450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM64_RS08460	COG1269	ATP hydrolysis coupled proton transport
CTM64_RS08470	COG0352	thiamine-phosphate diphosphorylase activity
CTM64_RS08480	COG2022	thiamine diphosphate biosynthetic process
CTM64_RS08485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CTM64_RS08495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTM64_RS08500	COG0352	thiamine-phosphate diphosphorylase activity
CTM64_RS08505	COG0351	phosphomethylpyrimidine kinase
CTM64_RS08535	COG0697	spore germination
CTM64_RS08545	COG0488	(ABC) transporter
CTM64_RS08565	COG0606	chelatase, subunit chli
CTM64_RS08580	COG0672	)-iron permease
CTM64_RS08590	COG2190	(PTS) system
CTM64_RS08600	COG0616	signal peptide processing
CTM64_RS08615	COG1792	Involved in formation and maintenance of cell shape
CTM64_RS08625	COG1381	Involved in DNA repair and RecF pathway recombination
CTM64_RS08630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM64_RS08630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM64_RS08630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM64_RS08635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTM64_RS08640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTM64_RS08645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTM64_RS08650	COG4492	Belongs to the UPF0735 family
CTM64_RS08655	COG1253	flavin adenine dinucleotide binding
CTM64_RS08670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM64_RS08675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTM64_RS08680	COG0343	queuine tRNA-ribosyltransferase activity
CTM64_RS08690	COG2239	Acts as a magnesium transporter
CTM64_RS08705	COG1760	l-serine dehydratase
CTM64_RS08715	COG0632	four-way junction helicase activity
CTM64_RS08770	COG3210	domain, Protein
CTM64_RS08775	COG2831	hemolysin activation secretion protein
CTM64_RS08780	COG0826	peptidase U32
CTM64_RS08785	COG0305	Participates in initiation and elongation during chromosome replication
CTM64_RS08790	COG0359	binds to the 23S rRNA
CTM64_RS08800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTM64_RS08805	COG2204	response regulator
CTM64_RS08820	COG0811	peptide transport
CTM64_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM64_RS08895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTM64_RS08900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CTM64_RS08910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CTM64_RS08920	COG4865	methylaspartate mutase activity
CTM64_RS08935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTM64_RS08940	COG2031	fatty acid transporter
CTM64_RS08950	COG1757	Na H antiporter
CTM64_RS08955	COG5012	cobalamin binding
CTM64_RS08960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTM64_RS08975	COG1509	lysine 2,3-aminomutase activity
CTM64_RS08980	COG0604	alcohol dehydrogenase
CTM64_RS08985	COG3246	L-lysine catabolic process to acetate
CTM64_RS08990	COG1607	acyl-coa hydrolase
CTM64_RS09110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CTM64_RS09115	COG0583	DNA-binding transcription factor activity
CTM64_RS09125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CTM64_RS09150	COG4667	esterase of the alpha-beta hydrolase superfamily
CTM64_RS09155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM64_RS09160	COG0426	domain, Protein
CTM64_RS09165	COG0531	amino acid
CTM64_RS09170	COG0076	glutamate decarboxylase activity
CTM64_RS09185	COG1592	Rubrerythrin
CTM64_RS09215	COG0006	proline dipeptidase activity
CTM64_RS09220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTM64_RS09235	COG4608	Belongs to the ABC transporter superfamily
CTM64_RS09240	COG0444	Belongs to the ABC transporter superfamily
CTM64_RS09245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS09250	COG0601	transmembrane transport
CTM64_RS09260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTM64_RS09280	COG0384	phenazine biosynthesis protein PhzF
CTM64_RS09350	COG0233	cytoplasmic translational termination
CTM64_RS09355	COG0528	UMP kinase activity
CTM64_RS09370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTM64_RS09395	COG3177	Filamentation induced by cAMP protein fic
CTM64_RS09415	COG1982	Orn Lys Arg decarboxylase major
CTM64_RS09420	COG0201	protein transport
CTM64_RS09425	COG0200	Binds to the 23S rRNA
CTM64_RS09430	COG1841	ribosomal large subunit assembly
CTM64_RS09435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTM64_RS09440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTM64_RS09445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTM64_RS09450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTM64_RS09455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTM64_RS09460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CTM64_RS09470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTM64_RS09475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTM64_RS09480	COG0255	Belongs to the universal ribosomal protein uL29 family
CTM64_RS09485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTM64_RS09490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTM64_RS09495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTM64_RS09500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTM64_RS09505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTM64_RS09510	COG0089	rRNA binding
CTM64_RS09515	COG0088	Forms part of the polypeptide exit tunnel
CTM64_RS09520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTM64_RS09525	COG0051	transcription antitermination factor activity, RNA binding
CTM64_RS09535	COG4608	Belongs to the ABC transporter superfamily
CTM64_RS09540	COG0444	Belongs to the ABC transporter superfamily
CTM64_RS09545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS09555	COG0747	negative chemotaxis
CTM64_RS09560	COG2985	domain, Protein
CTM64_RS09560	COG0569	domain protein
CTM64_RS09570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTM64_RS09585	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTM64_RS09590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CTM64_RS09595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTM64_RS09600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTM64_RS09605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTM64_RS09610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTM64_RS09615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTM64_RS09630	COG2832	Protein of unknown function (DUF454)
CTM64_RS09655	COG1373	ATPase (AAA superfamily
CTM64_RS09690	COG0714	Associated with various cellular activities
CTM64_RS09695	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CTM64_RS09700	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CTM64_RS09705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTM64_RS09725	COG1418	mRNA catabolic process
CTM64_RS09745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTM64_RS09750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTM64_RS09755	COG1051	belongs to the nudix hydrolase family
CTM64_RS09760	COG3177	Filamentation induced by cAMP protein fic
CTM64_RS09765	COG0210	DNA helicase
CTM64_RS09765	COG0210	DNA helicase
CTM64_RS09775	COG0251	oxidation-reduction process
CTM64_RS09835	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CTM64_RS09840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CTM64_RS09865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTM64_RS09865	COG0731	radical SAM domain protein
CTM64_RS09885	COG2805	Type II/IV secretion system protein
CTM64_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
CTM64_RS09895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTM64_RS09900	COG0800	Aldolase
CTM64_RS09925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM64_RS09930	COG1555	photosystem II stabilization
CTM64_RS09930	COG1596	polysaccharide export
CTM64_RS09935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTM64_RS09955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CTM64_RS09960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTM64_RS09960	COG1519	Transferase
CTM64_RS09965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTM64_RS10015	COG1619	proteins homologs of microcin C7 resistance protein MccF
CTM64_RS10025	COG1032	radical SAM domain protein
CTM64_RS10030	COG1032	radical SAM domain protein
CTM64_RS10040	COG1032	radical SAM domain protein
CTM64_RS10075	COG1032	radical SAM domain protein
CTM64_RS10090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CTM64_RS10090	COG1263	PTS System
CTM64_RS10095	COG1739	Uncharacterized protein family UPF0029
CTM64_RS10110	COG4948	Mandelate Racemase Muconate Lactonizing
CTM64_RS10120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTM64_RS10125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTM64_RS10130	COG0009	L-threonylcarbamoyladenylate synthase
CTM64_RS10145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CTM64_RS10160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTM64_RS10190	COG1121	(ABC) transporter
CTM64_RS10200	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTM64_RS10215	COG1177	transmembrane transport
CTM64_RS10220	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTM64_RS10225	COG3842	ATPase activity
CTM64_RS10230	COG1971	Probably functions as a manganese efflux pump
CTM64_RS10265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTM64_RS10270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTM64_RS10275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTM64_RS10280	COG0740	serine-type endopeptidase activity
CTM64_RS10285	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTM64_RS10290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTM64_RS10290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTM64_RS10295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTM64_RS10300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTM64_RS10310	COG0195	Participates in both transcription termination and antitermination
CTM64_RS10315	COG0779	Required for maturation of 30S ribosomal subunits
CTM64_RS10340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTM64_RS10345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTM64_RS10350	COG0037	tRNA processing
CTM64_RS10355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTM64_RS10360	COG0513	Belongs to the DEAD box helicase family
CTM64_RS10390	COG0072	phenylalanine-tRNA ligase activity
CTM64_RS10390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM64_RS10415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTM64_RS10420	COG0187	DNA topoisomerase II activity
CTM64_RS10430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM64_RS10450	COG0594	ribonuclease P activity
CTM64_RS10455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTM64_RS10460	COG0706	membrane insertase activity
CTM64_RS10465	COG1847	R3H domain protein
CTM64_RS10470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTM64_RS10475	COG0445	tRNA wobble uridine modification
CTM64_RS10490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTM64_RS10500	COG0157	Belongs to the NadC ModD family
CTM64_RS10505	COG1827	regulation of RNA biosynthetic process
CTM64_RS10570	COG2814	Major facilitator Superfamily
CTM64_RS10575	COG1566	PFAM secretion protein HlyD family protein
CTM64_RS10585	COG0166	Belongs to the GPI family
CTM64_RS10595	COG1450	Type ii and iii secretion system protein
CTM64_RS10635	COG1459	type II secretion system
CTM64_RS10640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTM64_RS10650	COG0582	viral genome integration into host DNA
CTM64_RS10740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTM64_RS10745	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CTM64_RS10750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CTM64_RS10755	COG2088	sporulation resulting in formation of a cellular spore
CTM64_RS10785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTM64_RS10790	COG4820	ethanolamine utilization protein (EutJ)
CTM64_RS10800	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM64_RS10800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTM64_RS10800	COG0539	negative regulation of cytoplasmic translation
CTM64_RS10880	COG0469	pyruvate kinase activity
CTM64_RS10885	COG0148	phosphopyruvate hydratase activity
CTM64_RS10895	COG3022	response to hydroperoxide
CTM64_RS10910	COG3263	regulation of cellular component size
CTM64_RS10920	COG1496	oxidoreductase activity
CTM64_RS10925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTM64_RS10960	COG0641	radical SAM
CTM64_RS10965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM64_RS10975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CTM64_RS11015	COG2871	sodium ion transport
CTM64_RS11025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTM64_RS11030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTM64_RS11040	COG1598	PFAM Uncharacterised protein family UPF0150
CTM64_RS11055	COG2226	methyltransferase
CTM64_RS11070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTM64_RS11075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTM64_RS11135	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CTM64_RS11140	COG0017	Asparaginyl-tRNA synthetase
CTM64_RS11145	COG4224	UPF0291 protein
CTM64_RS11150	COG0772	Belongs to the SEDS family
CTM64_RS11165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTM64_RS11170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTM64_RS11175	COG0708	Exodeoxyribonuclease III
CTM64_RS11190	COG0647	UMP catabolic process
CTM64_RS11225	COG1401	restriction endodeoxyribonuclease activity
CTM64_RS11240	COG0542	response to heat
CTM64_RS11300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CTM64_RS11300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CTM64_RS11310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTM64_RS11315	COG0534	Mate efflux family protein
CTM64_RS11355	COG1129	ABC transporter
CTM64_RS11375	COG2992	FlgJ-related protein
CTM64_RS11390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CTM64_RS11400	COG1393	Belongs to the ArsC family
CTM64_RS11405	COG1114	Component of the transport system for branched-chain amino acids
CTM64_RS11410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTM64_RS11525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTM64_RS11530	COG1104	cysteine desulfurase activity
CTM64_RS11535	COG0822	iron-sulfur transferase activity
CTM64_RS11540	COG1686	Belongs to the peptidase S11 family
CTM64_RS11545	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CTM64_RS11560	COG0735	belongs to the Fur family
CTM64_RS11565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CTM64_RS11580	COG0250	Participates in transcription elongation, termination and antitermination
CTM64_RS11585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTM64_RS11590	COG0081	regulation of translation
CTM64_RS11595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTM64_RS11600	COG0222	ribosome binding
CTM64_RS11610	COG0085	RNA polymerase activity
CTM64_RS11615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTM64_RS11620	COG1561	YicC-like family, N-terminal region
CTM64_RS11625	COG0194	GDP metabolic process
CTM64_RS11630	COG1758	RNA polymerase activity
CTM64_RS11635	COG1477	protein flavinylation
CTM64_RS11640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CTM64_RS11645	COG2755	lipolytic protein G-D-S-L family
CTM64_RS11645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CTM64_RS11655	COG1288	antiporter activity
CTM64_RS11660	COG1757	Na H antiporter
CTM64_RS11790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTM64_RS11795	COG1119	ATPase activity
CTM64_RS11800	COG0473	3-isopropylmalate dehydrogenase activity
CTM64_RS11820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTM64_RS11825	COG0440	acetolactate synthase activity
CTM64_RS11830	COG0028	Belongs to the TPP enzyme family
CTM64_RS11835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTM64_RS11840	COG0129	dihydroxy-acid dehydratase activity
CTM64_RS11845	COG0450	alkyl hydroperoxide reductase
CTM64_RS11855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CTM64_RS11860	COG0012	GTP binding
CTM64_RS11865	COG0149	triose-phosphate isomerase activity
CTM64_RS11885	COG0792	nuclease activity
CTM64_RS11890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTM64_RS11900	COG0564	pseudouridine synthase activity
CTM64_RS11905	COG3118	belongs to the thioredoxin family
CTM64_RS11980	COG0215	cysteine-tRNA ligase activity
CTM64_RS11985	COG1193	negative regulation of DNA recombination
CTM64_RS11990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTM64_RS11995	COG0215	cysteine-tRNA ligase activity
CTM64_RS12000	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CTM64_RS12010	COG0470	DNA polymerase III
CTM64_RS12020	COG2827	Endonuclease containing a URI domain
CTM64_RS12080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM64_RS12130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTM64_RS12135	COG0049	tRNA binding
CTM64_RS12140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM64_RS12145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTM64_RS12230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTM64_RS12235	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CTM64_RS12240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CTM64_RS12260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM64_RS12265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM64_RS12275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTM64_RS12280	COG0006	proline dipeptidase activity
CTM64_RS12310	COG0193	aminoacyl-tRNA hydrolase activity
CTM64_RS12315	COG4656	Part of a membrane complex involved in electron transport
CTM64_RS12320	COG4658	electron transport chain
CTM64_RS12325	COG4659	FMN binding
CTM64_RS12330	COG4660	Part of a membrane complex involved in electron transport
CTM64_RS12335	COG4657	Part of a membrane complex involved in electron transport
CTM64_RS12360	COG1959	2 iron, 2 sulfur cluster binding
CTM64_RS12370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTM64_RS12375	COG1346	cytolysis
CTM64_RS12380	COG1380	Effector of murein hydrolase LrgA
CTM64_RS12385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTM64_RS12395	COG1960	acyl-CoA dehydrogenase activity
CTM64_RS12400	COG0277	FAD linked oxidase domain protein
CTM64_RS12410	COG0003	Pfam Anion-transporting ATPase
CTM64_RS12415	COG1556	Lactate utilization protein
CTM64_RS12420	COG1139	Iron-sulfur cluster binding protein
CTM64_RS12435	COG2226	methyltransferase
CTM64_RS12440	COG0644	oxidoreductase
CTM64_RS12450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM64_RS12460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTM64_RS12460	COG0512	Glutamine amidotransferase of anthranilate synthase
CTM64_RS12475	COG1373	ATPase (AAA superfamily
CTM64_RS12485	COG1373	ATPase (AAA superfamily
CTM64_RS12505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CTM64_RS12515	COG0275	rRNA processing
CTM64_RS12525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTM64_RS12530	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM64_RS12535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTM64_RS12555	COG3052	prosthetic group binding
CTM64_RS12755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CTM64_RS12765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CTM64_RS12770	COG2003	Belongs to the UPF0758 family
CTM64_RS12775	COG1774	PSP1 C-terminal conserved region
CTM64_RS12780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTM64_RS12810	COG0848	biopolymer transport protein
CTM64_RS12820	COG1799	cell septum assembly
CTM64_RS12825	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTM64_RS12825	COG1388	LysM domain
CTM64_RS12840	COG4145	pantothenate transmembrane transporter activity
CTM64_RS12855	COG0747	negative chemotaxis
CTM64_RS12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM64_RS12870	COG0444	Belongs to the ABC transporter superfamily
CTM64_RS12875	COG4608	Belongs to the ABC transporter superfamily
CTM64_RS12880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTM64_RS12890	COG0577	efflux transmembrane transporter activity
CTM64_RS12895	COG0577	efflux transmembrane transporter activity
CTM64_RS12895	COG1136	(ABC) transporter
CTM64_RS12900	COG1136	(ABC) transporter
CTM64_RS12920	COG1136	(ABC) transporter
CTM64_RS12935	COG0584	glycerophosphoryl diester phosphodiesterase
CTM64_RS12940	COG1115	amino acid carrier protein
CTM64_RS13010	COG0228	four-way junction DNA binding
CTM64_RS13015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTM64_RS13020	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CTM64_RS13025	COG0442	prolyl-tRNA aminoacylation
CTM64_RS13030	COG0360	Binds together with S18 to 16S ribosomal RNA
CTM64_RS13035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CTM64_RS13040	COG0501	Belongs to the peptidase M48B family
CTM64_RS13050	COG4115	mRNA cleavage
CTM64_RS13055	COG0789	Transcriptional regulator
CTM64_RS13060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTM64_RS13085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CTM64_RS13090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTM64_RS13105	COG3681	Belongs to the UPF0597 family
CTM64_RS13130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTM64_RS13145	COG0579	oxidoreductase
CTM64_RS13150	COG0785	Cytochrome C biogenesis protein
CTM64_RS13155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM64_RS13160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM64_RS13160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM64_RS13175	COG1609	Transcriptional regulator
CTM64_RS13175	COG2207	Transcriptional regulator
CTM64_RS13180	COG2972	Histidine kinase
CTM64_RS13205	COG0534	Mate efflux family protein
CTM64_RS13215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CTM64_RS13225	COG1346	cytolysis
CTM64_RS13230	COG1380	Effector of murein hydrolase LrgA
CTM64_RS13235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTM64_RS13250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTM64_RS13255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTM64_RS13260	COG3023	N-Acetylmuramoyl-L-alanine amidase
CTM64_RS13265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTM64_RS13270	COG1272	protein, Hemolysin III
CTM64_RS13285	COG0501	Belongs to the peptidase M48B family
CTM64_RS13290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CTM64_RS13295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTM64_RS13325	COG0126	phosphoglycerate kinase activity
CTM64_RS13335	COG0564	pseudouridine synthase activity
CTM64_RS13345	COG2990	Protein conserved in bacteria
CTM64_RS13350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CTM64_RS13365	COG2610	gluconate transmembrane transporter activity
CTM64_RS13370	COG3048	D-serine ammonia-lyase activity
CTM64_RS13380	COG1132	(ABC) transporter
CTM64_RS13385	COG1132	(ABC) transporter
CTM64_RS13390	COG1309	transcriptional regulator
CTM64_RS13405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CTM64_RS13410	COG2385	sporulation resulting in formation of a cellular spore
CTM64_RS13435	COG0785	Cytochrome C biogenesis protein
CTM64_RS13475	COG2183	response to ionizing radiation
CTM64_RS13480	COG2205	protein histidine kinase activity
CTM64_RS13485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTM64_RS13490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTM64_RS13495	COG0752	glycyl-tRNA synthetase alpha subunit
CTM64_RS13500	COG0751	glycine-tRNA ligase activity
CTM64_RS13505	COG0302	gtp cyclohydrolase
CTM64_RS13510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTM64_RS13510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTM64_RS13515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTM64_RS13525	COG0481	GTPase activity
CTM64_RS13545	COG4303	Ethanolamine ammonia lyase large subunit
CTM64_RS13550	COG4302	ethanolamine ammonia-lyase activity
CTM64_RS13555	COG4816	utilization protein
CTM64_RS13560	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CTM64_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
CTM64_RS13570	COG1454	alcohol dehydrogenase
CTM64_RS13595	COG3192	ethanolamine utilization protein
CTM64_RS13620	COG1151	hydroxylamine reductase activity
CTM64_RS13635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTM64_RS13670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CTM64_RS13680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM64_RS13690	COG0101	tRNA pseudouridine synthase activity
CTM64_RS13700	COG1960	acyl-CoA dehydrogenase activity
CTM64_RS13705	COG0426	domain, Protein
CTM64_RS13715	COG2066	Belongs to the glutaminase family