locus-tag	class	description
CTM86_RS00110	COG1193	negative regulation of DNA recombination
CTM86_RS00115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTM86_RS00120	COG0215	cysteine-tRNA ligase activity
CTM86_RS00125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CTM86_RS00135	COG0470	DNA polymerase III
CTM86_RS00140	COG2827	Endonuclease containing a URI domain
CTM86_RS00205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM86_RS00220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTM86_RS00225	COG0049	tRNA binding
CTM86_RS00230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM86_RS00235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTM86_RS00240	COG0786	glutamate:sodium symporter activity
CTM86_RS00295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTM86_RS00300	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CTM86_RS00305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CTM86_RS00330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM86_RS00335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM86_RS00345	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTM86_RS00350	COG0006	proline dipeptidase activity
CTM86_RS00395	COG0193	aminoacyl-tRNA hydrolase activity
CTM86_RS00400	COG4656	Part of a membrane complex involved in electron transport
CTM86_RS00405	COG4658	electron transport chain
CTM86_RS00410	COG4659	FMN binding
CTM86_RS00415	COG4660	Part of a membrane complex involved in electron transport
CTM86_RS00420	COG4657	Part of a membrane complex involved in electron transport
CTM86_RS00440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTM86_RS00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM86_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTM86_RS00455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTM86_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
CTM86_RS00470	COG1373	ATPase (AAA superfamily
CTM86_RS00485	COG1401	restriction endodeoxyribonuclease activity
CTM86_RS00500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CTM86_RS00510	COG0275	rRNA processing
CTM86_RS00520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTM86_RS00525	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM86_RS00530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTM86_RS00540	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM86_RS00545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTM86_RS00565	COG3052	prosthetic group binding
CTM86_RS00675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CTM86_RS00680	COG0406	alpha-ribazole phosphatase activity
CTM86_RS00685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CTM86_RS00690	COG2003	Belongs to the UPF0758 family
CTM86_RS00695	COG1774	PSP1 C-terminal conserved region
CTM86_RS00700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTM86_RS00705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CTM86_RS00720	COG0848	biopolymer transport protein
CTM86_RS00730	COG1799	cell septum assembly
CTM86_RS00750	COG0747	negative chemotaxis
CTM86_RS00760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM86_RS00765	COG0444	Belongs to the ABC transporter superfamily
CTM86_RS00770	COG4608	Belongs to the ABC transporter superfamily
CTM86_RS00775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTM86_RS00785	COG0577	efflux transmembrane transporter activity
CTM86_RS00790	COG0577	efflux transmembrane transporter activity
CTM86_RS00790	COG1136	(ABC) transporter
CTM86_RS00795	COG1136	(ABC) transporter
CTM86_RS00815	COG1136	(ABC) transporter
CTM86_RS00895	COG0228	four-way junction DNA binding
CTM86_RS00900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTM86_RS00905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CTM86_RS00910	COG0442	prolyl-tRNA aminoacylation
CTM86_RS00915	COG0360	Binds together with S18 to 16S ribosomal RNA
CTM86_RS00920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CTM86_RS00925	COG4783	chaperone-mediated protein folding
CTM86_RS00930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTM86_RS00945	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CTM86_RS00950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTM86_RS00960	COG3681	Belongs to the UPF0597 family
CTM86_RS00970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTM86_RS00985	COG0579	oxidoreductase
CTM86_RS01000	COG0785	Cytochrome C biogenesis protein
CTM86_RS01005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM86_RS01010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM86_RS01010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM86_RS01020	COG2972	Histidine kinase
CTM86_RS01030	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CTM86_RS01040	COG1346	cytolysis
CTM86_RS01045	COG1380	Effector of murein hydrolase LrgA
CTM86_RS01050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTM86_RS01065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTM86_RS01070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTM86_RS01075	COG3023	N-Acetylmuramoyl-L-alanine amidase
CTM86_RS01085	COG1272	protein, Hemolysin III
CTM86_RS01090	COG4115	mRNA cleavage
CTM86_RS01105	COG0501	Belongs to the peptidase M48B family
CTM86_RS01110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CTM86_RS01145	COG0126	phosphoglycerate kinase activity
CTM86_RS01160	COG0564	pseudouridine synthase activity
CTM86_RS01200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CTM86_RS01205	COG2385	sporulation resulting in formation of a cellular spore
CTM86_RS01220	COG0785	Cytochrome C biogenesis protein
CTM86_RS01260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTM86_RS01285	COG4804	nuclease activity
CTM86_RS01305	COG2183	response to ionizing radiation
CTM86_RS01310	COG2205	protein histidine kinase activity
CTM86_RS01315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTM86_RS01320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTM86_RS01325	COG0752	glycyl-tRNA synthetase alpha subunit
CTM86_RS01335	COG0751	glycine-tRNA ligase activity
CTM86_RS01340	COG0302	gtp cyclohydrolase
CTM86_RS01345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTM86_RS01345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTM86_RS01350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTM86_RS01360	COG0481	GTPase activity
CTM86_RS01380	COG4303	Ethanolamine ammonia lyase large subunit
CTM86_RS01385	COG4302	ethanolamine ammonia-lyase activity
CTM86_RS01390	COG4816	utilization protein
CTM86_RS01395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CTM86_RS01405	COG1454	alcohol dehydrogenase
CTM86_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
CTM86_RS01430	COG3192	ethanolamine utilization protein
CTM86_RS01460	COG1151	hydroxylamine reductase activity
CTM86_RS01470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM86_RS01470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM86_RS01470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM86_RS01475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTM86_RS01510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CTM86_RS01520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM86_RS01530	COG0101	tRNA pseudouridine synthase activity
CTM86_RS01540	COG1960	acyl-CoA dehydrogenase activity
CTM86_RS01545	COG0426	domain, Protein
CTM86_RS01555	COG2066	Belongs to the glutaminase family
CTM86_RS01560	COG1115	amino acid carrier protein
CTM86_RS01620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTM86_RS01625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTM86_RS01625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTM86_RS01640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTM86_RS01640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTM86_RS01645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTM86_RS01650	COG1045	serine acetyltransferase
CTM86_RS01680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTM86_RS01700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM86_RS01710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTM86_RS01715	COG0254	rRNA binding
CTM86_RS01735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTM86_RS01740	COG0739	heme binding
CTM86_RS01745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTM86_RS01750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM86_RS01760	COG0203	ribosomal protein L17
CTM86_RS01765	COG0202	RNA polymerase activity
CTM86_RS01770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTM86_RS01775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTM86_RS01780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTM86_RS01790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTM86_RS01830	COG1278	Cold shock
CTM86_RS01835	COG0517	IMP dehydrogenase activity
CTM86_RS01835	COG0516	GMP reductase activity
CTM86_RS01875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CTM86_RS01880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTM86_RS01885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CTM86_RS01890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTM86_RS01890	COG3153	acetyltransferase
CTM86_RS01915	COG0202	RNA polymerase activity
CTM86_RS01960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CTM86_RS01970	COG0569	domain protein
CTM86_RS01975	COG0617	tRNA 3'-terminal CCA addition
CTM86_RS01980	COG1196	nuclear chromosome segregation
CTM86_RS01995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTM86_RS02000	COG1115	amino acid carrier protein
CTM86_RS02010	COG4589	Belongs to the CDS family
CTM86_RS02015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTM86_RS02020	COG2267	carboxylic ester hydrolase activity
CTM86_RS02025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTM86_RS02060	COG0481	GTPase activity
CTM86_RS02080	COG2966	Psort location CytoplasmicMembrane, score
CTM86_RS02085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTM86_RS02090	COG1960	acyl-CoA dehydrogenase activity
CTM86_RS02095	COG2086	electron transfer activity
CTM86_RS02100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTM86_RS02110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTM86_RS02120	COG2986	histidine ammonia-lyase
CTM86_RS02125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CTM86_RS02140	COG4608	Belongs to the ABC transporter superfamily
CTM86_RS02145	COG0601	transmembrane transport
CTM86_RS02150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM86_RS02160	COG0747	negative chemotaxis
CTM86_RS02165	COG4166	transmembrane transport
CTM86_RS02190	COG0460	homoserine dehydrogenase
CTM86_RS02195	COG0527	aspartate kinase activity
CTM86_RS02220	COG1132	(ABC) transporter
CTM86_RS02225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM86_RS02235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM86_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTM86_RS02250	COG0210	DNA helicase
CTM86_RS02265	COG5002	protein histidine kinase activity
CTM86_RS02270	COG0745	RESPONSE REGULATOR receiver
CTM86_RS02275	COG1136	(ABC) transporter
CTM86_RS02285	COG4953	penicillin-binding protein 1C
CTM86_RS02310	COG0514	ATP-dependent DNA helicase (RecQ)
CTM86_RS02335	COG1598	PFAM Uncharacterised protein family UPF0150
CTM86_RS02355	COG5002	protein histidine kinase activity
CTM86_RS02355	COG3850	Histidine kinase
CTM86_RS02360	COG1573	uracil-dna glycosylase
CTM86_RS02365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM86_RS02375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM86_RS02380	COG0647	UMP catabolic process
CTM86_RS02385	COG0778	Nitroreductase
CTM86_RS02395	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CTM86_RS02400	COG1914	H( )-stimulated, divalent metal cation uptake system
CTM86_RS02405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CTM86_RS02410	COG1984	allophanate hydrolase subunit 2
CTM86_RS02420	COG0561	phosphatase activity
CTM86_RS02430	COG0726	polysaccharide deacetylase
CTM86_RS02480	COG0110	maltose O-acetyltransferase activity
CTM86_RS02495	COG1132	(ABC) transporter
CTM86_RS02500	COG1132	(ABC) transporter
CTM86_RS02530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTM86_RS02545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTM86_RS02555	COG1464	Belongs to the NlpA lipoprotein family
CTM86_RS02560	COG2011	ABC-type metal ion transport system permease component
CTM86_RS02565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTM86_RS02570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTM86_RS02575	COG0786	glutamate:sodium symporter activity
CTM86_RS02585	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CTM86_RS02660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM86_RS02670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CTM86_RS02700	COG3177	Filamentation induced by cAMP protein fic
CTM86_RS02705	COG1797	cobyrinic acid a,c-diamide synthase activity
CTM86_RS02710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTM86_RS02730	COG0602	queuosine metabolic process
CTM86_RS02735	COG1328	CTP reductase activity
CTM86_RS02735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTM86_RS02740	COG3842	ATPase activity
CTM86_RS02745	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTM86_RS02770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTM86_RS02775	COG0124	histidyl-tRNA synthetase
CTM86_RS02820	COG3958	Transketolase
CTM86_RS02825	COG3959	Transketolase, thiamine diphosphate binding domain
CTM86_RS02835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTM86_RS02840	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTM86_RS02845	COG0280	phosphate acetyltransferase
CTM86_RS02890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CTM86_RS02895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CTM86_RS02895	COG1648	precorrin-2 dehydrogenase activity
CTM86_RS02910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CTM86_RS02915	COG0540	Belongs to the ATCase OTCase family
CTM86_RS02920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTM86_RS02925	COG0505	Belongs to the CarA family
CTM86_RS02930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTM86_RS02935	COG0543	2 iron, 2 sulfur cluster binding
CTM86_RS02940	COG0167	dihydroorotate dehydrogenase activity
CTM86_RS02955	COG0284	orotidine-5'-phosphate decarboxylase activity
CTM86_RS02965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CTM86_RS02985	COG0405	Gamma-glutamyltransferase
CTM86_RS03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTM86_RS03020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTM86_RS03025	COG0736	holo-[acyl-carrier-protein] synthase activity
CTM86_RS03030	COG0084	hydrolase, TatD family'
CTM86_RS03050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTM86_RS03055	COG4589	Belongs to the CDS family
CTM86_RS03060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTM86_RS03070	COG0750	zinc metalloprotease
CTM86_RS03075	COG2204	response regulator
CTM86_RS03085	COG0358	DNA primase activity
CTM86_RS03090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM86_RS03135	COG1132	(ABC) transporter
CTM86_RS03140	COG4988	ABC transporter
CTM86_RS03145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CTM86_RS03150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTM86_RS03170	COG1136	(ABC) transporter
CTM86_RS03175	COG0577	efflux transmembrane transporter activity
CTM86_RS03200	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CTM86_RS03205	COG0494	nUDIX hydrolase
CTM86_RS03210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CTM86_RS03210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CTM86_RS03215	COG0802	atpase or kinase
CTM86_RS03220	COG1214	PFAM Peptidase M22, glycoprotease
CTM86_RS03255	COG2315	Protein conserved in bacteria
CTM86_RS03270	COG4221	oxidoreductase activity
CTM86_RS03275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CTM86_RS03290	COG0517	IMP dehydrogenase activity
CTM86_RS03290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTM86_RS03295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CTM86_RS03305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTM86_RS03315	COG1024	Enoyl-CoA hydratase
CTM86_RS03320	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTM86_RS03325	COG0482	sulfurtransferase activity
CTM86_RS03330	COG1799	cell septum assembly
CTM86_RS03335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTM86_RS03340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM86_RS03345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM86_RS03390	COG0701	Predicted permease
CTM86_RS03450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CTM86_RS03455	COG0716	FMN binding
CTM86_RS03480	COG2255	four-way junction helicase activity
CTM86_RS03490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTM86_RS03495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM86_RS03510	COG0768	penicillin binding
CTM86_RS03515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CTM86_RS03520	COG1534	Rna-binding protein
CTM86_RS03525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTM86_RS03535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTM86_RS03540	COG0793	Belongs to the peptidase S41A family
CTM86_RS03540	COG3409	Peptidoglycan-binding domain 1 protein
CTM86_RS03545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTM86_RS03550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTM86_RS03555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTM86_RS03570	COG1862	Preprotein translocase
CTM86_RS03585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTM86_RS03590	COG2890	protein-(glutamine-N5) methyltransferase activity
CTM86_RS03595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTM86_RS03600	COG0742	ribosomal rna small subunit methyltransferase
CTM86_RS03605	COG1722	exodeoxyribonuclease VII activity
CTM86_RS03620	COG4120	Belongs to the binding-protein-dependent transport system permease family
CTM86_RS03625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTM86_RS03635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTM86_RS03635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTM86_RS03645	COG2116	formate transmembrane transporter activity
CTM86_RS03655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTM86_RS03660	COG3384	dioxygenase
CTM86_RS03670	COG4974	Belongs to the 'phage' integrase family
CTM86_RS03700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTM86_RS03705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTM86_RS03710	COG1121	(ABC) transporter
CTM86_RS03715	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTM86_RS03725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CTM86_RS03730	COG0534	Mate efflux family protein
CTM86_RS03735	COG0436	Aminotransferase
CTM86_RS03745	COG1295	ribonuclease BN
CTM86_RS03750	COG0768	penicillin binding
CTM86_RS03755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTM86_RS03760	COG0242	peptide deformylase activity
CTM86_RS03770	COG1494	fructose-1,6-bisphosphatase
CTM86_RS03800	COG0133	tryptophan synthase activity
CTM86_RS03830	COG1242	4 iron, 4 sulfur cluster binding
CTM86_RS03835	COG0363	glucosamine-6-phosphate deaminase activity
CTM86_RS03840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CTM86_RS03845	COG1687	branched-chain amino acid
CTM86_RS03860	COG2996	Protein conserved in bacteria
CTM86_RS03920	COG0346	lactoylglutathione lyase activity
CTM86_RS03975	COG1114	Component of the transport system for branched-chain amino acids
CTM86_RS03985	COG3831	ATPase activity
CTM86_RS03985	COG4884	unkown
CTM86_RS03990	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTM86_RS03995	COG0557	exoribonuclease II activity
CTM86_RS04000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTM86_RS04010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTM86_RS04040	COG0424	maF-like protein
CTM86_RS04045	COG1077	Cell shape determining protein MreB Mrl
CTM86_RS04050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTM86_RS04055	COG1187	pseudouridine synthase activity
CTM86_RS04060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTM86_RS04065	COG0154	amidase activity
CTM86_RS04070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTM86_RS04080	COG0252	asparaginase activity
CTM86_RS04095	COG2333	competence protein COMEC
CTM86_RS04095	COG0658	competence protein
CTM86_RS04110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CTM86_RS04120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTM86_RS04140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTM86_RS04145	COG0497	DNA recombination
CTM86_RS04150	COG4974	Belongs to the 'phage' integrase family
CTM86_RS04155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTM86_RS04165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTM86_RS04170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTM86_RS04175	COG1116	anion transmembrane transporter activity
CTM86_RS04180	COG0629	single-stranded DNA binding
CTM86_RS04190	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM86_RS04200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTM86_RS04215	COG1164	Oligoendopeptidase f
CTM86_RS04305	COG4974	Belongs to the 'phage' integrase family
CTM86_RS04310	COG1335	isochorismatase
CTM86_RS04315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CTM86_RS04320	COG0181	hydroxymethylbilane synthase activity
CTM86_RS04365	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CTM86_RS04370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CTM86_RS04375	COG3639	organic phosphonate transmembrane transporter activity
CTM86_RS04395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CTM86_RS04400	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CTM86_RS04410	COG0151	Belongs to the GarS family
CTM86_RS04420	COG0138	bifunctional purine biosynthesis protein purh
CTM86_RS04425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTM86_RS04430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTM86_RS04435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTM86_RS04440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTM86_RS04445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTM86_RS04450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTM86_RS04455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CTM86_RS04460	COG0556	nucleotide-excision repair
CTM86_RS04465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTM86_RS04475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM86_RS04475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM86_RS04530	COG4106	trans-aconitate 2-methyltransferase activity
CTM86_RS04535	COG0494	nUDIX hydrolase
CTM86_RS04545	COG0210	DNA helicase
CTM86_RS04550	COG1362	aminopeptidase activity
CTM86_RS04555	COG2502	aspartate--ammonia ligase
CTM86_RS04580	COG0747	negative chemotaxis
CTM86_RS04585	COG0668	transmembrane transport
CTM86_RS04605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTM86_RS04610	COG0534	Mate efflux family protein
CTM86_RS04615	COG0776	regulation of translation
CTM86_RS04630	COG1492	cobalamin metabolic process
CTM86_RS04655	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CTM86_RS04660	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CTM86_RS04665	COG1924	4 iron, 4 sulfur cluster binding
CTM86_RS04670	COG0786	glutamate:sodium symporter activity
CTM86_RS04675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTM86_RS04680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTM86_RS04685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTM86_RS04690	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CTM86_RS04695	COG0511	ligase activity, forming carbon-carbon bonds
CTM86_RS04695	COG5016	pyruvate
CTM86_RS04710	COG0534	Mate efflux family protein
CTM86_RS04715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTM86_RS04760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTM86_RS04765	COG4206	TonB-dependent receptor
CTM86_RS04770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM86_RS04775	COG1120	ATPase activity
CTM86_RS04780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM86_RS04795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTM86_RS04805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTM86_RS04810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CTM86_RS04815	COG4868	Belongs to the UPF0371 family
CTM86_RS04820	COG1022	Amp-dependent synthetase and ligase
CTM86_RS04825	COG1363	Peptidase, m42
CTM86_RS04830	COG1854	S-ribosylhomocysteine lyase activity
CTM86_RS04870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTM86_RS04890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTM86_RS04895	COG1217	gtp-binding protein TYPA
CTM86_RS04925	COG3177	Filamentation induced by cAMP protein fic
CTM86_RS04930	COG0588	phosphoglycerate mutase activity
CTM86_RS04940	COG1323	Belongs to the UPF0348 family
CTM86_RS04950	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM86_RS04955	COG1032	radical SAM domain protein
CTM86_RS04965	COG2211	Major facilitator Superfamily
CTM86_RS04985	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CTM86_RS04990	COG1518	maintenance of DNA repeat elements
CTM86_RS04995	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CTM86_RS05005	COG0552	protein localization to endoplasmic reticulum
CTM86_RS05015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTM86_RS05020	COG4974	Belongs to the 'phage' integrase family
CTM86_RS05025	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CTM86_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTM86_RS05035	COG0758	DNA mediated transformation
CTM86_RS05045	COG1570	exodeoxyribonuclease VII activity
CTM86_RS05055	COG4115	mRNA cleavage
CTM86_RS05075	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CTM86_RS05085	COG0601	transmembrane transport
CTM86_RS05090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM86_RS05095	COG0747	negative chemotaxis
CTM86_RS05100	COG0444	Belongs to the ABC transporter superfamily
CTM86_RS05115	COG1228	amidohydrolase
CTM86_RS05125	COG3404	Formiminotransferase-cyclodeaminase
CTM86_RS05150	COG1309	transcriptional regulator
CTM86_RS05160	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CTM86_RS05165	COG0427	acetyl-CoA hydrolase
CTM86_RS05175	COG1966	Carbon starvation protein
CTM86_RS05180	COG3275	phosphorelay sensor kinase activity
CTM86_RS05185	COG3279	Response regulator of the LytR AlgR family
CTM86_RS05190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CTM86_RS05200	COG4221	oxidoreductase activity
CTM86_RS05205	COG1285	pathogenesis
CTM86_RS05210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTM86_RS05215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CTM86_RS05230	COG1704	LemA family
CTM86_RS05250	COG0823	Involved in the tonB-independent uptake of proteins
CTM86_RS05250	COG1506	peptidase
CTM86_RS05250	COG4946	Tricorn protease homolog
CTM86_RS05255	COG0765	amino acid transport
CTM86_RS05260	COG4215	(ABC) transporter
CTM86_RS05270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTM86_RS05275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTM86_RS05280	COG1480	7TM receptor with intracellular HD hydrolase
CTM86_RS05285	COG1199	ATP-dependent helicase activity
CTM86_RS05290	COG4807	Protein conserved in bacteria
CTM86_RS05295	COG0297	glycogen (starch) synthase activity
CTM86_RS05300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTM86_RS05305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTM86_RS05310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTM86_RS05315	COG0058	SHG alpha-glucan phosphorylase activity
CTM86_RS05340	COG0670	Belongs to the BI1 family
CTM86_RS05350	COG0037	tRNA processing
CTM86_RS05355	COG0561	phosphatase activity
CTM86_RS05360	COG1054	Belongs to the UPF0176 family
CTM86_RS05365	COG0248	Ppx GppA phosphatase
CTM86_RS05365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTM86_RS05380	COG0616	signal peptide processing
CTM86_RS05390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CTM86_RS05395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTM86_RS05400	COG0776	regulation of translation
CTM86_RS05405	COG2252	PERMEase
CTM86_RS05410	COG0564	pseudouridine synthase activity
CTM86_RS05415	COG0772	Belongs to the SEDS family
CTM86_RS05420	COG0756	dUTP diphosphatase activity
CTM86_RS05425	COG0612	Peptidase, M16
CTM86_RS05450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTM86_RS05460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTM86_RS05465	COG0584	glycerophosphoryl diester phosphodiesterase
CTM86_RS05470	COG0598	Magnesium transport protein CorA
CTM86_RS05475	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CTM86_RS05500	COG4211	Belongs to the binding-protein-dependent transport system permease family
CTM86_RS05505	COG1129	ABC transporter
CTM86_RS05525	COG0492	ferredoxin-NADP+ reductase activity
CTM86_RS05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTM86_RS05535	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTM86_RS05540	COG1660	Displays ATPase and GTPase activities
CTM86_RS05545	COG0322	excinuclease ABC activity
CTM86_RS05555	COG3872	metal-dependent enzyme
CTM86_RS05565	COG0488	(ABC) transporter
CTM86_RS05575	COG0563	adenylate kinase activity
CTM86_RS05590	COG2217	Heavy metal translocating P-type atpase
CTM86_RS05600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM86_RS05600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM86_RS05610	COG0196	riboflavin kinase activity
CTM86_RS05620	COG0728	peptidoglycan biosynthetic process
CTM86_RS05665	COG1187	pseudouridine synthase activity
CTM86_RS05680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTM86_RS05690	COG0416	fatty acid biosynthetic process
CTM86_RS05695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTM86_RS05700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTM86_RS05705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTM86_RS05710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTM86_RS05715	COG0571	ribonuclease III activity
CTM86_RS05720	COG1242	4 iron, 4 sulfur cluster binding
CTM86_RS05725	COG1530	ribonuclease E activity
CTM86_RS05735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTM86_RS05740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTM86_RS05745	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTM86_RS05755	COG0183	Belongs to the thiolase family
CTM86_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
CTM86_RS05785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTM86_RS05790	COG0335	large ribosomal subunit rRNA binding
CTM86_RS05795	COG3829	transcription factor binding
CTM86_RS05800	COG3804	dihydrodipicolinate reductase
CTM86_RS05810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTM86_RS05820	COG5012	cobalamin binding
CTM86_RS05830	COG4187	Peptidase family M20/M25/M40
CTM86_RS05835	COG1115	amino acid carrier protein
CTM86_RS05840	COG3457	Alanine racemase
CTM86_RS05850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTM86_RS05855	COG2926	Belongs to the UPF0265 family
CTM86_RS05860	COG0205	6-phosphofructokinase activity
CTM86_RS05865	COG0825	malonyl-CoA metabolic process
CTM86_RS05870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CTM86_RS05880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTM86_RS05885	COG0180	Tryptophanyl-tRNA synthetase
CTM86_RS05890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTM86_RS05895	COG0217	transcriptional regulatory protein
CTM86_RS05900	COG1461	Dihydroxyacetone kinase
CTM86_RS05910	COG1546	Belongs to the CinA family
CTM86_RS05910	COG1058	Belongs to the CinA family
CTM86_RS05915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CTM86_RS05920	COG0826	peptidase U32
CTM86_RS05925	COG0237	dephospho-CoA kinase activity
CTM86_RS05955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CTM86_RS05960	COG1970	mechanosensitive ion channel activity
CTM86_RS05965	COG0482	sulfurtransferase activity
CTM86_RS05985	COG0357	Ribosomal RNA small subunit methyltransferase G
CTM86_RS05990	COG0445	tRNA wobble uridine modification
CTM86_RS05995	COG0569	domain protein
CTM86_RS06000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTM86_RS06005	COG0534	Mate efflux family protein
CTM86_RS06015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CTM86_RS06030	COG0525	valine-tRNA ligase activity
CTM86_RS06040	COG1174	glycine betaine transport
CTM86_RS06045	COG1125	glycine betaine transport
CTM86_RS06055	COG1132	(ABC) transporter
CTM86_RS06065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTM86_RS06070	COG0285	dihydrofolate synthase activity
CTM86_RS06080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CTM86_RS06085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTM86_RS06090	COG4166	transmembrane transport
CTM86_RS06095	COG4221	oxidoreductase activity
CTM86_RS06110	COG3588	fructose-bisphosphate aldolase
CTM86_RS06115	COG0326	Molecular chaperone. Has ATPase activity
CTM86_RS06140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTM86_RS06145	COG2137	regulation of response to DNA damage stimulus
CTM86_RS06150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTM86_RS06165	COG0859	PFAM glycosyl transferase family 9
CTM86_RS06175	COG0463	Glycosyl transferase, family 2
CTM86_RS06180	COG0726	polysaccharide deacetylase
CTM86_RS06185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTM86_RS06210	COG0653	protein targeting
CTM86_RS06215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTM86_RS06225	COG0482	sulfurtransferase activity
CTM86_RS06250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM86_RS06250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM86_RS06250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM86_RS06255	COG1105	Belongs to the carbohydrate kinase PfkB family
CTM86_RS06260	COG1349	DNA-binding transcription factor activity
CTM86_RS06335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTM86_RS06340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CTM86_RS06345	COG0210	DNA helicase
CTM86_RS06355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM86_RS06360	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTM86_RS06400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTM86_RS06410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTM86_RS06415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTM86_RS06425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM86_RS06430	COG2217	Heavy metal translocating P-type atpase
CTM86_RS06440	COG0640	Transcriptional regulator
CTM86_RS06510	COG1283	sodium-dependent phosphate transmembrane transporter activity
CTM86_RS06520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTM86_RS06540	COG4752	Belongs to the RNA methyltransferase TrmD family
CTM86_RS06545	COG0336	Belongs to the RNA methyltransferase TrmD family
CTM86_RS06550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTM86_RS06555	COG1837	Belongs to the UPF0109 family
CTM86_RS06565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTM86_RS06570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTM86_RS06635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTM86_RS06640	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTM86_RS06645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTM86_RS06650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTM86_RS06655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM86_RS06660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTM86_RS06665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM86_RS06685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM86_RS06695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTM86_RS06700	COG0456	acetyltransferase
CTM86_RS06705	COG0681	Belongs to the peptidase S26 family
CTM86_RS06730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTM86_RS06730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTM86_RS06735	COG1840	ABC-type Fe3 transport system, periplasmic component
CTM86_RS06740	COG3842	ATPase activity
CTM86_RS06790	COG1288	antiporter activity
CTM86_RS06830	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CTM86_RS06840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTM86_RS06845	COG1162	GTPase activity
CTM86_RS06940	COG0010	Belongs to the arginase family
CTM86_RS06945	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTM86_RS06960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM86_RS06965	COG1115	amino acid carrier protein
CTM86_RS06970	COG1492	cobalamin metabolic process
CTM86_RS06985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM86_RS07025	COG0765	amino acid transport
CTM86_RS07030	COG1126	abc transporter atp-binding protein
CTM86_RS07035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTM86_RS07050	COG0733	neurotransmitter:sodium symporter activity
CTM86_RS07075	COG2056	Na+-H+ antiporter family
CTM86_RS07080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTM86_RS07090	COG0116	Belongs to the methyltransferase superfamily
CTM86_RS07105	COG0688	phosphatidylethanolamine metabolic process
CTM86_RS07110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CTM86_RS07115	COG1490	D-aminoacyl-tRNA deacylase activity
CTM86_RS07130	COG1288	antiporter activity
CTM86_RS07150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CTM86_RS07155	COG0113	porphobilinogen synthase activity
CTM86_RS07175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTM86_RS07180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTM86_RS07185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTM86_RS07200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTM86_RS07230	COG1183	phosphatidylcholine synthase activity
CTM86_RS07240	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CTM86_RS07245	COG0574	Belongs to the PEP-utilizing enzyme family
CTM86_RS07245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM86_RS07250	COG0517	IMP dehydrogenase activity
CTM86_RS07270	COG0626	cystathionine gamma-synthase activity
CTM86_RS07280	COG4452	Inner membrane protein CreD
CTM86_RS07300	COG1268	BioY protein
CTM86_RS07305	COG1122	ATPase activity
CTM86_RS07310	COG1122	ATPase activity
CTM86_RS07315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTM86_RS07320	COG2264	protein methyltransferase activity
CTM86_RS07325	COG1692	metallophosphoesterase
CTM86_RS07345	COG1420	regulation of RNA biosynthetic process
CTM86_RS07350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTM86_RS07355	COG0443	Heat shock 70 kDa protein
CTM86_RS07370	COG4797	methyltransferase
CTM86_RS07370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CTM86_RS07375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTM86_RS07380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTM86_RS07385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTM86_RS07390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTM86_RS07395	COG1137	ATPase activity
CTM86_RS07405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTM86_RS07410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTM86_RS07415	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CTM86_RS07420	COG2894	cell division
CTM86_RS07425	COG0850	regulation of cytokinetic process
CTM86_RS07455	COG1160	GTP binding
CTM86_RS07465	COG0537	adenosine 5'-monophosphoramidase activity
CTM86_RS07470	COG0698	ribose 5-phosphate isomerase
CTM86_RS07490	COG0268	Binds directly to 16S ribosomal RNA
CTM86_RS07500	COG0519	Catalyzes the synthesis of GMP from XMP
CTM86_RS07500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTM86_RS07510	COG1088	dTDP-glucose 4,6-dehydratase activity
CTM86_RS07565	COG1088	dTDP-glucose 4,6-dehydratase activity
CTM86_RS07570	COG1091	dTDP-4-dehydrorhamnose reductase activity
CTM86_RS07575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTM86_RS07585	COG1216	Glycosyl transferase, family 2
CTM86_RS07585	COG1442	glycosyl transferase family 8
CTM86_RS07615	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CTM86_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTM86_RS07635	COG1968	undecaprenyl-diphosphatase activity
CTM86_RS07640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM86_RS07645	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTM86_RS07650	COG0730	response to heat
CTM86_RS07655	COG2017	converts alpha-aldose to the beta-anomer
CTM86_RS07665	COG0444	Belongs to the ABC transporter superfamily
CTM86_RS07670	COG0747	negative chemotaxis
CTM86_RS07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM86_RS07680	COG0601	transmembrane transport
CTM86_RS07690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTM86_RS07695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTM86_RS07700	COG1595	DNA-templated transcription, initiation
CTM86_RS07705	COG0495	leucyl-tRNA aminoacylation
CTM86_RS07725	COG1802	Transcriptional regulator
CTM86_RS07730	COG3033	Beta-eliminating lyase
CTM86_RS07735	COG0733	neurotransmitter:sodium symporter activity
CTM86_RS07740	COG1394	ATPase activity, coupled to movement of substances
CTM86_RS07745	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CTM86_RS07755	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CTM86_RS07760	COG1527	subunit (C
CTM86_RS07765	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CTM86_RS07770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM86_RS07775	COG1269	ATP hydrolysis coupled proton transport
CTM86_RS07785	COG0352	thiamine-phosphate diphosphorylase activity
CTM86_RS07795	COG2022	thiamine diphosphate biosynthetic process
CTM86_RS07800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CTM86_RS07810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTM86_RS07815	COG0352	thiamine-phosphate diphosphorylase activity
CTM86_RS07820	COG0351	phosphomethylpyrimidine kinase
CTM86_RS07850	COG0697	spore germination
CTM86_RS07865	COG0488	(ABC) transporter
CTM86_RS07875	COG0606	chelatase, subunit chli
CTM86_RS07890	COG0672	)-iron permease
CTM86_RS07905	COG2190	(PTS) system
CTM86_RS07915	COG0616	signal peptide processing
CTM86_RS07930	COG1792	Involved in formation and maintenance of cell shape
CTM86_RS07940	COG1381	Involved in DNA repair and RecF pathway recombination
CTM86_RS07945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM86_RS07945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTM86_RS07945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTM86_RS07950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTM86_RS07955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTM86_RS07960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTM86_RS07965	COG4492	Belongs to the UPF0735 family
CTM86_RS07970	COG1253	flavin adenine dinucleotide binding
CTM86_RS07985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM86_RS07990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTM86_RS07995	COG0343	queuine tRNA-ribosyltransferase activity
CTM86_RS08000	COG2239	Acts as a magnesium transporter
CTM86_RS08015	COG3177	Filamentation induced by cAMP protein fic
CTM86_RS08025	COG1760	l-serine dehydratase
CTM86_RS08035	COG0632	four-way junction helicase activity
CTM86_RS08050	COG0826	peptidase U32
CTM86_RS08055	COG0305	Participates in initiation and elongation during chromosome replication
CTM86_RS08060	COG0359	binds to the 23S rRNA
CTM86_RS08070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTM86_RS08075	COG2204	response regulator
CTM86_RS08090	COG0811	peptide transport
CTM86_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
CTM86_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM86_RS08155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTM86_RS08160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CTM86_RS08170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CTM86_RS08180	COG4865	methylaspartate mutase activity
CTM86_RS08195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTM86_RS08200	COG2031	fatty acid transporter
CTM86_RS08210	COG1757	Na H antiporter
CTM86_RS08215	COG5012	cobalamin binding
CTM86_RS08220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTM86_RS08225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTM86_RS08235	COG1509	lysine 2,3-aminomutase activity
CTM86_RS08240	COG0604	alcohol dehydrogenase
CTM86_RS08245	COG3246	L-lysine catabolic process to acetate
CTM86_RS08250	COG1607	acyl-coa hydrolase
CTM86_RS08335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CTM86_RS08340	COG0583	DNA-binding transcription factor activity
CTM86_RS08350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CTM86_RS08355	COG0018	arginyl-trna synthetase
CTM86_RS08360	COG4667	esterase of the alpha-beta hydrolase superfamily
CTM86_RS08365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM86_RS08370	COG0426	domain, Protein
CTM86_RS08400	COG1592	Rubrerythrin
CTM86_RS08415	COG0006	proline dipeptidase activity
CTM86_RS08420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTM86_RS08435	COG4608	Belongs to the ABC transporter superfamily
CTM86_RS08440	COG0444	Belongs to the ABC transporter superfamily
CTM86_RS08445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTM86_RS08450	COG0601	transmembrane transport
CTM86_RS08460	COG0747	negative chemotaxis
CTM86_RS08465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTM86_RS08475	COG0384	phenazine biosynthesis protein PhzF
CTM86_RS08570	COG0233	cytoplasmic translational termination
CTM86_RS08575	COG0528	UMP kinase activity
CTM86_RS08580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTM86_RS08585	COG0052	Belongs to the universal ribosomal protein uS2 family
CTM86_RS08590	COG1982	Orn Lys Arg decarboxylase major
CTM86_RS08595	COG0201	protein transport
CTM86_RS08600	COG0200	Binds to the 23S rRNA
CTM86_RS08605	COG1841	ribosomal large subunit assembly
CTM86_RS08610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTM86_RS08615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTM86_RS08620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTM86_RS08625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTM86_RS08630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTM86_RS08635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CTM86_RS08645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTM86_RS08650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTM86_RS08655	COG0255	Belongs to the universal ribosomal protein uL29 family
CTM86_RS08660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTM86_RS08665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTM86_RS08670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTM86_RS08675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTM86_RS08680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTM86_RS08685	COG0089	rRNA binding
CTM86_RS08690	COG0088	Forms part of the polypeptide exit tunnel
CTM86_RS08695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTM86_RS08700	COG0051	transcription antitermination factor activity, RNA binding
CTM86_RS08710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTM86_RS08725	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTM86_RS08730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CTM86_RS08735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTM86_RS08740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTM86_RS08745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTM86_RS08750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTM86_RS08755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTM86_RS08780	COG2832	Protein of unknown function (DUF454)
CTM86_RS08815	COG0714	Associated with various cellular activities
CTM86_RS08820	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CTM86_RS08825	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CTM86_RS08830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTM86_RS08850	COG1418	mRNA catabolic process
CTM86_RS08870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTM86_RS08875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTM86_RS08880	COG1051	belongs to the nudix hydrolase family
CTM86_RS08885	COG3177	Filamentation induced by cAMP protein fic
CTM86_RS08900	COG0251	oxidation-reduction process
CTM86_RS08905	COG4206	TonB-dependent receptor
CTM86_RS08915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM86_RS08920	COG1120	ATPase activity
CTM86_RS08940	COG0542	response to heat
CTM86_RS09015	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CTM86_RS09020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CTM86_RS09045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTM86_RS09045	COG0731	radical SAM domain protein
CTM86_RS09090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM86_RS09095	COG1596	polysaccharide export
CTM86_RS09095	COG1555	photosystem II stabilization
CTM86_RS09100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTM86_RS09115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CTM86_RS09125	COG1519	Transferase
CTM86_RS09125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTM86_RS09135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTM86_RS09200	COG1032	radical SAM domain protein
CTM86_RS09205	COG1032	radical SAM domain protein
CTM86_RS09210	COG1032	radical SAM domain protein
CTM86_RS09245	COG1032	radical SAM domain protein
CTM86_RS09255	COG1263	PTS System
CTM86_RS09255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CTM86_RS09260	COG1739	Uncharacterized protein family UPF0029
CTM86_RS09275	COG0322	excinuclease ABC activity
CTM86_RS09285	COG4948	Mandelate Racemase Muconate Lactonizing
CTM86_RS09290	COG0484	heat shock protein binding
CTM86_RS09295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTM86_RS09300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTM86_RS09305	COG0009	L-threonylcarbamoyladenylate synthase
CTM86_RS09320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CTM86_RS09350	COG1121	(ABC) transporter
CTM86_RS09360	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTM86_RS09375	COG1177	transmembrane transport
CTM86_RS09380	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTM86_RS09385	COG3842	ATPase activity
CTM86_RS09390	COG1971	Probably functions as a manganese efflux pump
CTM86_RS09420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTM86_RS09425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTM86_RS09430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTM86_RS09435	COG0740	serine-type endopeptidase activity
CTM86_RS09440	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTM86_RS09445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTM86_RS09445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTM86_RS09450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTM86_RS09455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTM86_RS09465	COG0195	Participates in both transcription termination and antitermination
CTM86_RS09470	COG0779	Required for maturation of 30S ribosomal subunits
CTM86_RS09480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTM86_RS09485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTM86_RS09490	COG0037	tRNA processing
CTM86_RS09495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTM86_RS09500	COG0513	Belongs to the DEAD box helicase family
CTM86_RS09530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM86_RS09530	COG0072	phenylalanine-tRNA ligase activity
CTM86_RS09535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CTM86_RS09545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTM86_RS09550	COG0187	DNA topoisomerase II activity
CTM86_RS09560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM86_RS09580	COG0594	ribonuclease P activity
CTM86_RS09585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTM86_RS09590	COG0706	membrane insertase activity
CTM86_RS09595	COG1847	R3H domain protein
CTM86_RS09600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTM86_RS09605	COG0445	tRNA wobble uridine modification
CTM86_RS09610	COG1279	arginine transmembrane transporter activity
CTM86_RS09615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTM86_RS09625	COG0157	Belongs to the NadC ModD family
CTM86_RS09630	COG1827	regulation of RNA biosynthetic process
CTM86_RS09655	COG0166	Belongs to the GPI family
CTM86_RS09665	COG1450	Type ii and iii secretion system protein
CTM86_RS09705	COG1459	type II secretion system
CTM86_RS09710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTM86_RS09750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTM86_RS09755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CTM86_RS09760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CTM86_RS09765	COG2088	sporulation resulting in formation of a cellular spore
CTM86_RS09780	COG1053	succinate dehydrogenase
CTM86_RS09795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTM86_RS09800	COG4820	ethanolamine utilization protein (EutJ)
CTM86_RS09810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTM86_RS09810	COG0539	negative regulation of cytoplasmic translation
CTM86_RS09810	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM86_RS09885	COG0469	pyruvate kinase activity
CTM86_RS09890	COG0148	phosphopyruvate hydratase activity
CTM86_RS09900	COG3022	response to hydroperoxide
CTM86_RS09915	COG3263	regulation of cellular component size
CTM86_RS09925	COG1496	oxidoreductase activity
CTM86_RS09930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTM86_RS09940	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CTM86_RS09985	COG2871	sodium ion transport
CTM86_RS09995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTM86_RS10000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTM86_RS10005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM86_RS10010	COG2226	methyltransferase
CTM86_RS10030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTM86_RS10035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTM86_RS10095	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CTM86_RS10100	COG0017	Asparaginyl-tRNA synthetase
CTM86_RS10125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTM86_RS10130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTM86_RS10135	COG0708	Exodeoxyribonuclease III
CTM86_RS10150	COG0647	UMP catabolic process
CTM86_RS10170	COG0542	response to heat
CTM86_RS10240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CTM86_RS10240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CTM86_RS10245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTM86_RS10250	COG0534	Mate efflux family protein
CTM86_RS10280	COG1129	ABC transporter
CTM86_RS10300	COG2992	FlgJ-related protein
CTM86_RS10325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CTM86_RS10340	COG1393	Belongs to the ArsC family
CTM86_RS10345	COG1114	Component of the transport system for branched-chain amino acids
CTM86_RS10350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTM86_RS10445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTM86_RS10450	COG1104	cysteine desulfurase activity
CTM86_RS10455	COG0822	iron-sulfur transferase activity
CTM86_RS10460	COG1686	Belongs to the peptidase S11 family
CTM86_RS10465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CTM86_RS10480	COG0735	belongs to the Fur family
CTM86_RS10485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CTM86_RS10500	COG0250	Participates in transcription elongation, termination and antitermination
CTM86_RS10505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTM86_RS10510	COG0081	regulation of translation
CTM86_RS10515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTM86_RS10520	COG0222	ribosome binding
CTM86_RS10530	COG0085	RNA polymerase activity
CTM86_RS10535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTM86_RS10540	COG1561	YicC-like family, N-terminal region
CTM86_RS10545	COG0194	GDP metabolic process
CTM86_RS10550	COG1758	RNA polymerase activity
CTM86_RS10555	COG1477	protein flavinylation
CTM86_RS10560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CTM86_RS10565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CTM86_RS10565	COG2755	lipolytic protein G-D-S-L family
CTM86_RS10570	COG1288	antiporter activity
CTM86_RS10575	COG1757	Na H antiporter
CTM86_RS10660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTM86_RS10665	COG1119	ATPase activity
CTM86_RS10670	COG0473	3-isopropylmalate dehydrogenase activity
CTM86_RS10680	COG0066	3-isopropylmalate dehydratase activity
CTM86_RS10690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTM86_RS10695	COG0440	acetolactate synthase activity
CTM86_RS10700	COG0028	Belongs to the TPP enzyme family
CTM86_RS10705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTM86_RS10710	COG0129	dihydroxy-acid dehydratase activity
CTM86_RS10715	COG0450	alkyl hydroperoxide reductase
CTM86_RS10725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CTM86_RS10730	COG0012	GTP binding
CTM86_RS10735	COG0149	triose-phosphate isomerase activity
CTM86_RS10755	COG0792	nuclease activity
CTM86_RS10760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTM86_RS10765	COG0564	pseudouridine synthase activity
CTM86_RS10770	COG3118	belongs to the thioredoxin family
CTM86_RS10845	COG0582	viral genome integration into host DNA
CTM86_RS10920	COG1484	DNA-dependent DNA replication