locus-tag	class	description
C4N20_RS00015	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N20_RS00020	COG0191	fructose-bisphosphate aldolase activity
C4N20_RS00030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4N20_RS00040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4N20_RS00050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4N20_RS00060	COG0357	Ribosomal RNA small subunit methyltransferase G
C4N20_RS00065	COG0445	tRNA wobble uridine modification
C4N20_RS00070	COG0569	domain protein
C4N20_RS00075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4N20_RS00080	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N20_RS00090	COG1846	Transcriptional regulator
C4N20_RS00125	COG3299	homolog of phage Mu protein gp47
C4N20_RS00195	COG0740	serine-type endopeptidase activity
C4N20_RS00350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C4N20_RS00365	COG4974	Belongs to the 'phage' integrase family
C4N20_RS00390	COG0583	DNA-binding transcription factor activity
C4N20_RS00405	COG0583	DNA-binding transcription factor activity
C4N20_RS00420	COG3033	Beta-eliminating lyase
C4N20_RS00425	COG1115	amino acid carrier protein
C4N20_RS00430	COG1301	dicarboxylic acid transport
C4N20_RS00435	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4N20_RS00440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4N20_RS00445	COG1288	antiporter activity
C4N20_RS00450	COG1473	amidohydrolase
C4N20_RS00455	COG0019	diaminopimelate decarboxylase activity
C4N20_RS00470	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4N20_RS00480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4N20_RS00515	COG1492	cobalamin metabolic process
C4N20_RS00520	COG1757	Na H antiporter
C4N20_RS00525	COG0165	Argininosuccinate lyase
C4N20_RS00535	COG1840	ABC-type Fe3 transport system, periplasmic component
C4N20_RS00540	COG3842	ATPase activity
C4N20_RS00545	COG4149	molybdate abc transporter
C4N20_RS00550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4N20_RS00555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4N20_RS00555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4N20_RS00560	COG1592	Rubrerythrin
C4N20_RS00575	COG2153	protein acetylation
C4N20_RS00610	COG3711	transcriptional antiterminator
C4N20_RS00610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS00615	COG0776	regulation of translation
C4N20_RS00630	COG1959	2 iron, 2 sulfur cluster binding
C4N20_RS00635	COG1115	amino acid carrier protein
C4N20_RS00645	COG1799	cell septum assembly
C4N20_RS00650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4N20_RS00655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N20_RS00660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N20_RS00665	COG0786	glutamate:sodium symporter activity
C4N20_RS00680	COG0534	Mate efflux family protein
C4N20_RS00690	COG2364	Membrane
C4N20_RS00695	COG1162	GTPase activity
C4N20_RS00725	COG4145	pantothenate transmembrane transporter activity
C4N20_RS00730	COG0747	negative chemotaxis
C4N20_RS00735	COG1473	amidohydrolase
C4N20_RS00740	COG0747	negative chemotaxis
C4N20_RS00745	COG1473	amidohydrolase
C4N20_RS00750	COG0747	negative chemotaxis
C4N20_RS00755	COG1473	amidohydrolase
C4N20_RS00760	COG0242	peptide deformylase activity
C4N20_RS00770	COG0697	spore germination
C4N20_RS00780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N20_RS00780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N20_RS00810	COG1288	antiporter activity
C4N20_RS00855	COG1022	Amp-dependent synthetase and ligase
C4N20_RS00865	COG1022	Amp-dependent synthetase and ligase
C4N20_RS00875	COG1272	protein, Hemolysin III
C4N20_RS00890	COG1802	Transcriptional regulator
C4N20_RS00895	COG1757	Na H antiporter
C4N20_RS00905	COG3304	Inner membrane component domain
C4N20_RS00910	COG0037	tRNA processing
C4N20_RS00915	COG0037	tRNA processing
C4N20_RS00970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4N20_RS00975	COG0616	signal peptide processing
C4N20_RS00980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N20_RS00995	COG1253	flavin adenine dinucleotide binding
C4N20_RS01000	COG0697	spore germination
C4N20_RS01005	COG1164	Oligoendopeptidase f
C4N20_RS01020	COG4175	Glycine betaine
C4N20_RS01020	COG3448	diguanylate cyclase activity
C4N20_RS01030	COG2233	PERMEase
C4N20_RS01045	COG1564	THIamine pyrophosphokinase
C4N20_RS01065	COG1924	4 iron, 4 sulfur cluster binding
C4N20_RS01070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4N20_RS01075	COG2188	Transcriptional regulator
C4N20_RS01090	COG3842	ATPase activity
C4N20_RS01095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4N20_RS01100	COG0646	methionine synthase
C4N20_RS01100	COG1410	methionine synthase
C4N20_RS01110	COG0281	malic enzyme
C4N20_RS01125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4N20_RS01160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4N20_RS01165	COG0779	Required for maturation of 30S ribosomal subunits
C4N20_RS01170	COG0195	Participates in both transcription termination and antitermination
C4N20_RS01180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4N20_RS01185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4N20_RS01190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4N20_RS01190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4N20_RS01195	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4N20_RS01200	COG0740	serine-type endopeptidase activity
C4N20_RS01205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4N20_RS01210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4N20_RS01215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4N20_RS01220	COG0525	valine-tRNA ligase activity
C4N20_RS01230	COG0561	phosphatase activity
C4N20_RS01235	COG0583	DNA-binding transcription factor activity
C4N20_RS01240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4N20_RS01250	COG1696	Membrane protein involved in D-alanine export
C4N20_RS01265	COG1132	(ABC) transporter
C4N20_RS01275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4N20_RS01280	COG2089	acid synthase
C4N20_RS01285	COG0110	maltose O-acetyltransferase activity
C4N20_RS01290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4N20_RS01295	COG1086	Polysaccharide biosynthesis protein
C4N20_RS01320	COG3754	Rhamnan synthesis protein F
C4N20_RS01325	COG1216	Glycosyl transferase, family 2
C4N20_RS01335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N20_RS01345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4N20_RS01360	COG1136	(ABC) transporter
C4N20_RS01370	COG4953	penicillin-binding protein 1C
C4N20_RS01375	COG2373	Large extracellular alpha-helical protein
C4N20_RS01380	COG0514	ATP-dependent DNA helicase (RecQ)
C4N20_RS01390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4N20_RS01405	COG0612	Peptidase, M16
C4N20_RS01415	COG3022	response to hydroperoxide
C4N20_RS01430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N20_RS01435	COG4820	ethanolamine utilization protein (EutJ)
C4N20_RS01465	COG4869	propanediol catabolic process
C4N20_RS01520	COG0745	RESPONSE REGULATOR receiver
C4N20_RS01530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4N20_RS01545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4N20_RS01560	COG2364	Membrane
C4N20_RS01565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4N20_RS01600	COG1217	gtp-binding protein TYPA
C4N20_RS01605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4N20_RS01625	COG4106	trans-aconitate 2-methyltransferase activity
C4N20_RS01635	COG0778	Nitroreductase
C4N20_RS01650	COG0137	argininosuccinate synthase activity
C4N20_RS01655	COG1716	ATPase activity
C4N20_RS01655	COG5001	Diguanylate cyclase
C4N20_RS01675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4N20_RS01685	COG0275	rRNA processing
C4N20_RS01695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4N20_RS01700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N20_RS01705	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N20_RS01715	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4N20_RS01725	COG0730	response to heat
C4N20_RS01735	COG1482	cell wall glycoprotein biosynthetic process
C4N20_RS01740	COG0488	(ABC) transporter
C4N20_RS01745	COG3711	transcriptional antiterminator
C4N20_RS01750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS01750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS01750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS01755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS01760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS01805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS01810	COG1757	Na H antiporter
C4N20_RS01840	COG4824	toxin secretion phage lysis holin
C4N20_RS02030	COG2842	Transposition protein
C4N20_RS02055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4N20_RS02090	COG4978	Transcriptional regulator
C4N20_RS02090	COG0789	Transcriptional regulator
C4N20_RS02110	COG1363	Peptidase, m42
C4N20_RS02130	COG2431	L-lysine efflux transmembrane transporter activity
C4N20_RS02150	COG1979	alcohol dehydrogenase
C4N20_RS02155	COG1346	cytolysis
C4N20_RS02165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4N20_RS02185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4N20_RS02190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4N20_RS02200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4N20_RS02200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4N20_RS02225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4N20_RS02235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4N20_RS02240	COG2207	Transcriptional regulator
C4N20_RS02240	COG4753	response regulator
C4N20_RS02245	COG2972	Histidine kinase
C4N20_RS02255	COG3842	ATPase activity
C4N20_RS02260	COG1840	ABC-type Fe3 transport system, periplasmic component
C4N20_RS02265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4N20_RS02270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4N20_RS02275	COG1132	(ABC) transporter
C4N20_RS02280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4N20_RS02285	COG3494	Protein of unknown function (DUF1009)
C4N20_RS02290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4N20_RS02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4N20_RS02325	COG1183	phosphatidylcholine synthase activity
C4N20_RS02330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4N20_RS02375	COG2851	Citrate transporter
C4N20_RS02380	COG3290	protein histidine kinase activity
C4N20_RS02380	COG3829	transcription factor binding
C4N20_RS02385	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4N20_RS02390	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4N20_RS02415	COG1506	peptidase
C4N20_RS02415	COG0823	Involved in the tonB-independent uptake of proteins
C4N20_RS02415	COG4946	Tricorn protease homolog
C4N20_RS02420	COG1196	nuclear chromosome segregation
C4N20_RS02430	COG0785	Cytochrome C biogenesis protein
C4N20_RS02440	COG3976	FMN-binding domain protein
C4N20_RS02440	COG1053	succinate dehydrogenase
C4N20_RS02455	COG0058	SHG alpha-glucan phosphorylase activity
C4N20_RS02460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4N20_RS02465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4N20_RS02470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4N20_RS02475	COG0297	glycogen (starch) synthase activity
C4N20_RS02500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4N20_RS02510	COG1086	Polysaccharide biosynthesis protein
C4N20_RS02530	COG1216	Glycosyl transferase, family 2
C4N20_RS02560	COG3475	LICD family
C4N20_RS02565	COG0859	PFAM glycosyl transferase family 9
C4N20_RS02585	COG0438	transferase activity, transferring glycosyl groups
C4N20_RS02595	COG1215	transferase activity, transferring glycosyl groups
C4N20_RS02615	COG3475	LICD family
C4N20_RS02635	COG1597	lipid kinase activity
C4N20_RS02640	COG0786	glutamate:sodium symporter activity
C4N20_RS02645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4N20_RS02650	COG0859	PFAM glycosyl transferase family 9
C4N20_RS02655	COG1757	Na H antiporter
C4N20_RS02670	COG1918	ferrous iron import across plasma membrane
C4N20_RS02670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4N20_RS02690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N20_RS02695	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4N20_RS02720	COG1881	PFAM PEBP family protein
C4N20_RS02730	COG1160	GTP binding
C4N20_RS02735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4N20_RS02740	COG2926	Belongs to the UPF0265 family
C4N20_RS02745	COG0205	6-phosphofructokinase activity
C4N20_RS02750	COG0825	malonyl-CoA metabolic process
C4N20_RS02755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4N20_RS02770	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4N20_RS02790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N20_RS02800	COG2252	PERMEase
C4N20_RS02805	COG0564	pseudouridine synthase activity
C4N20_RS02810	COG0772	Belongs to the SEDS family
C4N20_RS02815	COG0756	dUTP diphosphatase activity
C4N20_RS02820	COG0612	Peptidase, M16
C4N20_RS02845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4N20_RS02850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4N20_RS02855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4N20_RS02860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4N20_RS02865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4N20_RS02870	COG1137	ATPase activity
C4N20_RS02880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4N20_RS02890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4N20_RS02900	COG3118	belongs to the thioredoxin family
C4N20_RS02905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4N20_RS02910	COG1214	PFAM Peptidase M22, glycoprotease
C4N20_RS02915	COG0802	atpase or kinase
C4N20_RS02920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4N20_RS02920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4N20_RS02930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4N20_RS02935	COG0254	rRNA binding
C4N20_RS02955	COG1739	Uncharacterized protein family UPF0029
C4N20_RS02960	COG1994	Peptidase M50
C4N20_RS02965	COG2333	competence protein COMEC
C4N20_RS02965	COG0658	competence protein
C4N20_RS02970	COG2211	Major facilitator Superfamily
C4N20_RS02975	COG1323	Belongs to the UPF0348 family
C4N20_RS02980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4N20_RS02990	COG2801	Transposase and inactivated derivatives
C4N20_RS03025	COG0569	domain protein
C4N20_RS03040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4N20_RS03065	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4N20_RS03075	COG0714	Associated with various cellular activities
C4N20_RS03085	COG4589	Belongs to the CDS family
C4N20_RS03090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4N20_RS03095	COG2267	carboxylic ester hydrolase activity
C4N20_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
C4N20_RS03120	COG1960	acyl-CoA dehydrogenase activity
C4N20_RS03125	COG1757	Na H antiporter
C4N20_RS03130	COG0733	neurotransmitter:sodium symporter activity
C4N20_RS03135	COG0442	prolyl-tRNA aminoacylation
C4N20_RS03140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4N20_RS03145	COG0217	transcriptional regulatory protein
C4N20_RS03150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4N20_RS03160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4N20_RS03165	COG0747	negative chemotaxis
C4N20_RS03170	COG0747	negative chemotaxis
C4N20_RS03190	COG1473	amidohydrolase
C4N20_RS03195	COG1473	amidohydrolase
C4N20_RS03200	COG2226	methyltransferase
C4N20_RS03205	COG1773	rubredoxin
C4N20_RS03205	COG1592	Rubrerythrin
C4N20_RS03210	COG0300	oxidoreductase activity
C4N20_RS03215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4N20_RS03235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4N20_RS03245	COG1802	Transcriptional regulator
C4N20_RS03250	COG1827	regulation of RNA biosynthetic process
C4N20_RS03255	COG0157	Belongs to the NadC ModD family
C4N20_RS03265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4N20_RS03275	COG0786	glutamate:sodium symporter activity
C4N20_RS03280	COG1228	amidohydrolase
C4N20_RS03360	COG3119	arylsulfatase activity
C4N20_RS03370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4N20_RS03375	COG2190	(PTS) system
C4N20_RS03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS03375	COG1263	PTS System
C4N20_RS03380	COG2188	Transcriptional regulator
C4N20_RS03390	COG3775	system Galactitol-specific IIC component
C4N20_RS03400	COG3414	Phosphotransferase system galactitol-specific IIB component
C4N20_RS03405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS03410	COG1063	alcohol dehydrogenase
C4N20_RS03420	COG1105	Belongs to the carbohydrate kinase PfkB family
C4N20_RS03440	COG3177	Filamentation induced by cAMP protein fic
C4N20_RS03445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4N20_RS03450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4N20_RS03460	COG1053	succinate dehydrogenase
C4N20_RS03460	COG3976	FMN-binding domain protein
C4N20_RS03460	COG0431	NADPH-dependent FMN reductase
C4N20_RS03465	COG5002	protein histidine kinase activity
C4N20_RS03470	COG0745	RESPONSE REGULATOR receiver
C4N20_RS03485	COG0581	inorganic phosphate transmembrane transporter activity
C4N20_RS03490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4N20_RS03495	COG0704	Plays a role in the regulation of phosphate uptake
C4N20_RS03505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N20_RS03515	COG0656	L-ascorbic acid biosynthetic process
C4N20_RS03520	COG1929	Belongs to the glycerate kinase type-1 family
C4N20_RS03525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N20_RS03535	COG2084	Dehydrogenase
C4N20_RS03540	COG2610	gluconate transmembrane transporter activity
C4N20_RS03545	COG3835	regulator
C4N20_RS03555	COG2721	sulfolactate sulfo-lyase activity
C4N20_RS03560	COG0142	geranyltranstransferase activity
C4N20_RS03570	COG0742	ribosomal rna small subunit methyltransferase
C4N20_RS03575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4N20_RS03580	COG2890	protein-(glutamine-N5) methyltransferase activity
C4N20_RS03585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4N20_RS03615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4N20_RS03620	COG0739	heme binding
C4N20_RS03625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4N20_RS03630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N20_RS03635	COG2315	Protein conserved in bacteria
C4N20_RS03645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4N20_RS03650	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
C4N20_RS03655	COG2031	fatty acid transporter
C4N20_RS03660	COG5002	protein histidine kinase activity
C4N20_RS03665	COG0745	RESPONSE REGULATOR receiver
C4N20_RS03670	COG1937	Protein conserved in bacteria
C4N20_RS03675	COG2217	Heavy metal translocating P-type atpase
C4N20_RS03685	COG0584	glycerophosphoryl diester phosphodiesterase
C4N20_RS03690	COG1115	amino acid carrier protein
C4N20_RS03695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N20_RS03700	COG1263	PTS System
C4N20_RS03700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS03720	COG1968	undecaprenyl-diphosphatase activity
C4N20_RS03725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4N20_RS03740	COG0653	protein targeting
C4N20_RS03745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4N20_RS03755	COG4129	membrane
C4N20_RS03760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS03760	COG1263	PTS System
C4N20_RS03765	COG0482	sulfurtransferase activity
C4N20_RS03775	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4N20_RS03775	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4N20_RS03780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4N20_RS03785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS03785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N20_RS03785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS03790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4N20_RS03795	COG1461	Dihydroxyacetone kinase
C4N20_RS03805	COG1546	Belongs to the CinA family
C4N20_RS03805	COG1058	Belongs to the CinA family
C4N20_RS03815	COG0826	peptidase U32
C4N20_RS03820	COG0237	dephospho-CoA kinase activity
C4N20_RS03835	COG2252	PERMEase
C4N20_RS03845	COG3437	response regulator, receiver
C4N20_RS03895	COG5001	Diguanylate cyclase
C4N20_RS03925	COG0534	Mate efflux family protein
C4N20_RS03935	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS03940	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS03945	COG1144	Oxidoreductase
C4N20_RS03950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4N20_RS03960	COG1174	glycine betaine transport
C4N20_RS03965	COG2271	Major facilitator Superfamily
C4N20_RS03970	COG0626	cystathionine gamma-synthase activity
C4N20_RS03985	COG0716	FMN binding
C4N20_RS03995	COG4978	Transcriptional regulator
C4N20_RS03995	COG0789	Transcriptional regulator
C4N20_RS04010	COG0561	phosphatase activity
C4N20_RS04020	COG2095	MarC family integral membrane protein
C4N20_RS04050	COG1114	Component of the transport system for branched-chain amino acids
C4N20_RS04055	COG1114	Component of the transport system for branched-chain amino acids
C4N20_RS04060	COG1393	Belongs to the ArsC family
C4N20_RS04065	COG0737	Belongs to the 5'-nucleotidase family
C4N20_RS04105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4N20_RS04125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N20_RS04130	COG0436	Aminotransferase
C4N20_RS04135	COG2171	N-acyltransferase activity
C4N20_RS04140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4N20_RS04145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N20_RS04150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4N20_RS04160	COG1473	amidohydrolase
C4N20_RS04180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4N20_RS04185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N20_RS04195	COG1301	dicarboxylic acid transport
C4N20_RS04200	COG0191	fructose-bisphosphate aldolase activity
C4N20_RS04210	COG3246	L-lysine catabolic process to acetate
C4N20_RS04220	COG2186	Transcriptional regulator
C4N20_RS04225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N20_RS04225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4N20_RS04235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4N20_RS04260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N20_RS04265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4N20_RS04270	COG0793	Belongs to the peptidase S41A family
C4N20_RS04275	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4N20_RS04285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4N20_RS04290	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C4N20_RS04300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4N20_RS04305	COG0768	penicillin binding
C4N20_RS04320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4N20_RS04330	COG1959	2 iron, 2 sulfur cluster binding
C4N20_RS04335	COG2255	four-way junction helicase activity
C4N20_RS04355	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N20_RS04355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4N20_RS04355	COG0539	negative regulation of cytoplasmic translation
C4N20_RS04360	COG0539	negative regulation of cytoplasmic translation
C4N20_RS04360	COG1185	polyribonucleotide nucleotidyltransferase activity
C4N20_RS04360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4N20_RS04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4N20_RS04385	COG2378	regulation of single-species biofilm formation
C4N20_RS04395	COG1335	isochorismatase
C4N20_RS04405	COG1263	PTS System
C4N20_RS04405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS04405	COG2190	(PTS) system
C4N20_RS04410	COG1486	melibiose metabolic process
C4N20_RS04415	COG1464	Belongs to the NlpA lipoprotein family
C4N20_RS04425	COG2011	ABC-type metal ion transport system permease component
C4N20_RS04430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N20_RS04435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4N20_RS04445	COG0534	Mate efflux family protein
C4N20_RS04510	COG0534	Mate efflux family protein
C4N20_RS04530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4N20_RS04550	COG1288	antiporter activity
C4N20_RS04585	COG0583	DNA-binding transcription factor activity
C4N20_RS04590	COG3210	domain, Protein
C4N20_RS04590	COG3210	domain, Protein
C4N20_RS04680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4N20_RS04685	COG1940	carbohydrate kinase activity
C4N20_RS04690	COG0287	Prephenate dehydrogenase
C4N20_RS04695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4N20_RS04700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4N20_RS04705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4N20_RS04710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4N20_RS04715	COG1605	Chorismate mutase
C4N20_RS04715	COG0077	Prephenate dehydratase
C4N20_RS04745	COG1979	alcohol dehydrogenase
C4N20_RS04750	COG1349	DNA-binding transcription factor activity
C4N20_RS04755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4N20_RS04760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N20_RS04765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS04775	COG3829	transcription factor binding
C4N20_RS04785	COG0534	Mate efflux family protein
C4N20_RS04800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4N20_RS04810	COG1450	Type ii and iii secretion system protein
C4N20_RS04845	COG4969	Belongs to the N-Me-Phe pilin family
C4N20_RS04850	COG1459	type II secretion system
C4N20_RS04855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4N20_RS04875	COG0747	negative chemotaxis
C4N20_RS04880	COG0601	transmembrane transport
C4N20_RS04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N20_RS04890	COG0444	Belongs to the ABC transporter superfamily
C4N20_RS04895	COG4608	Belongs to the ABC transporter superfamily
C4N20_RS04900	COG0534	Mate efflux family protein
C4N20_RS04905	COG3608	succinylglutamate desuccinylase aspartoacylase
C4N20_RS05010	COG1132	(ABC) transporter
C4N20_RS05015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4N20_RS05020	COG4974	Belongs to the 'phage' integrase family
C4N20_RS05025	COG0497	DNA recombination
C4N20_RS05030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4N20_RS05045	COG3958	Transketolase
C4N20_RS05050	COG3959	Transketolase, thiamine diphosphate binding domain
C4N20_RS05060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4N20_RS05065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4N20_RS05070	COG0049	tRNA binding
C4N20_RS05075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4N20_RS05080	COG0488	(ABC) transporter
C4N20_RS05085	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4N20_RS05115	COG1917	Cupin 2, conserved barrel domain protein
C4N20_RS05115	COG2207	Transcriptional regulator
C4N20_RS05120	COG0697	spore germination
C4N20_RS05135	COG0148	phosphopyruvate hydratase activity
C4N20_RS05145	COG0191	fructose-bisphosphate aldolase activity
C4N20_RS05150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4N20_RS05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS05170	COG3711	transcriptional antiterminator
C4N20_RS05175	COG1053	succinate dehydrogenase
C4N20_RS05190	COG2721	sulfolactate sulfo-lyase activity
C4N20_RS05200	COG3300	MHYT domain
C4N20_RS05200	COG5001	Diguanylate cyclase
C4N20_RS05215	COG2199	diguanylate cyclase activity
C4N20_RS05220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4N20_RS05225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N20_RS05230	COG2731	YhcH YjgK YiaL family protein
C4N20_RS05235	COG1940	carbohydrate kinase activity
C4N20_RS05245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N20_RS05245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4N20_RS05270	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4N20_RS05280	COG1758	RNA polymerase activity
C4N20_RS05285	COG0194	GDP metabolic process
C4N20_RS05290	COG2052	Domain of unknown function (DUF370)
C4N20_RS05295	COG1561	YicC-like family, N-terminal region
C4N20_RS05300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4N20_RS05305	COG0085	RNA polymerase activity
C4N20_RS05310	COG0222	ribosome binding
C4N20_RS05315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4N20_RS05320	COG0081	regulation of translation
C4N20_RS05325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4N20_RS05330	COG0250	Participates in transcription elongation, termination and antitermination
C4N20_RS05365	COG0495	leucyl-tRNA aminoacylation
C4N20_RS05375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4N20_RS05380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4N20_RS05425	COG0745	RESPONSE REGULATOR receiver
C4N20_RS05430	COG5002	protein histidine kinase activity
C4N20_RS05435	COG0859	PFAM glycosyl transferase family 9
C4N20_RS05450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4N20_RS05455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4N20_RS05475	COG2137	regulation of response to DNA damage stimulus
C4N20_RS05480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4N20_RS05485	COG0859	PFAM glycosyl transferase family 9
C4N20_RS05505	COG0463	Glycosyl transferase, family 2
C4N20_RS05520	COG2033	superoxide reductase activity
C4N20_RS05535	COG0101	tRNA pseudouridine synthase activity
C4N20_RS05570	COG2885	chlorophyll binding
C4N20_RS05575	COG0039	L-malate dehydrogenase activity
C4N20_RS05585	COG2027	D-alanyl-D-alanine carboxypeptidase
C4N20_RS05595	COG1733	regulation of RNA biosynthetic process
C4N20_RS05610	COG0402	S-adenosylhomocysteine deaminase activity
C4N20_RS05615	COG2252	PERMEase
C4N20_RS05680	COG0126	phosphoglycerate kinase activity
C4N20_RS05690	COG0564	pseudouridine synthase activity
C4N20_RS05695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4N20_RS05700	COG0181	hydroxymethylbilane synthase activity
C4N20_RS05710	COG0113	porphobilinogen synthase activity
C4N20_RS05715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4N20_RS05720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4N20_RS05720	COG1648	precorrin-2 dehydrogenase activity
C4N20_RS05725	COG0251	oxidation-reduction process
C4N20_RS05745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4N20_RS05775	COG3829	transcription factor binding
C4N20_RS05780	COG0641	radical SAM
C4N20_RS05790	COG0488	(ABC) transporter
C4N20_RS05795	COG3681	Belongs to the UPF0597 family
C4N20_RS05815	COG0456	acetyltransferase
C4N20_RS05820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N20_RS05825	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4N20_RS05850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4N20_RS05860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N20_RS05865	COG1760	l-serine dehydratase
C4N20_RS05875	COG1396	sequence-specific DNA binding
C4N20_RS05920	COG1653	transport
C4N20_RS05925	COG3842	ATPase activity
C4N20_RS05930	COG0395	ABC-type sugar transport system, permease component
C4N20_RS05945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4N20_RS05950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C4N20_RS05980	COG0859	PFAM glycosyl transferase family 9
C4N20_RS05985	COG2990	Protein conserved in bacteria
C4N20_RS06005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS06015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N20_RS06025	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4N20_RS06040	COG0454	-acetyltransferase
C4N20_RS06055	COG1757	Na H antiporter
C4N20_RS06105	COG2878	Part of a membrane complex involved in electron transport
C4N20_RS06105	COG1245	4Fe-4S binding domain
C4N20_RS06110	COG4657	Part of a membrane complex involved in electron transport
C4N20_RS06115	COG4660	Part of a membrane complex involved in electron transport
C4N20_RS06120	COG4659	FMN binding
C4N20_RS06125	COG4658	electron transport chain
C4N20_RS06130	COG4656	Part of a membrane complex involved in electron transport
C4N20_RS06135	COG0193	aminoacyl-tRNA hydrolase activity
C4N20_RS06140	COG1760	l-serine dehydratase
C4N20_RS06145	COG0072	phenylalanine-tRNA ligase activity
C4N20_RS06145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N20_RS06150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4N20_RS06165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4N20_RS06170	COG0187	DNA topoisomerase II activity
C4N20_RS06185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4N20_RS06205	COG0594	ribonuclease P activity
C4N20_RS06210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4N20_RS06215	COG0706	membrane insertase activity
C4N20_RS06220	COG1847	R3H domain protein
C4N20_RS06225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4N20_RS06230	COG0445	tRNA wobble uridine modification
C4N20_RS06245	COG0747	negative chemotaxis
C4N20_RS06250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4N20_RS06255	COG3956	TIGRFAM MazG family protein
C4N20_RS06260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4N20_RS06265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4N20_RS06280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4N20_RS06305	COG1349	DNA-binding transcription factor activity
C4N20_RS06310	COG0561	phosphatase activity
C4N20_RS06360	COG0129	dihydroxy-acid dehydratase activity
C4N20_RS06365	COG2610	gluconate transmembrane transporter activity
C4N20_RS06375	COG0166	Belongs to the GPI family
C4N20_RS06380	COG0519	Catalyzes the synthesis of GMP from XMP
C4N20_RS06385	COG1362	aminopeptidase activity
C4N20_RS06395	COG1785	Belongs to the alkaline phosphatase family
C4N20_RS06425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4N20_RS06430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4N20_RS06435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4N20_RS06440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4N20_RS06445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4N20_RS06450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4N20_RS06455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4N20_RS06460	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4N20_RS06475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4N20_RS06480	COG0360	Binds together with S18 to 16S ribosomal RNA
C4N20_RS06485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4N20_RS06495	COG3829	transcription factor binding
C4N20_RS06505	COG1114	Component of the transport system for branched-chain amino acids
C4N20_RS06510	COG2207	Transcriptional regulator
C4N20_RS06510	COG3708	Transcriptional regulator
C4N20_RS06515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4N20_RS06520	COG1193	negative regulation of DNA recombination
C4N20_RS06525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4N20_RS06540	COG0215	cysteine-tRNA ligase activity
C4N20_RS06545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4N20_RS06550	COG1077	Cell shape determining protein MreB Mrl
C4N20_RS06555	COG0470	DNA polymerase III
C4N20_RS06560	COG0473	3-isopropylmalate dehydrogenase activity
C4N20_RS06560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4N20_RS06565	COG2207	Transcriptional regulator
C4N20_RS06570	COG2723	6-phospho-beta-galactosidase activity
C4N20_RS06575	COG3706	GGDEF domain
C4N20_RS06610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4N20_RS06615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4N20_RS06615	COG0731	radical SAM domain protein
C4N20_RS06635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4N20_RS06640	COG0531	amino acid
C4N20_RS06650	COG0051	transcription antitermination factor activity, RNA binding
C4N20_RS06655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4N20_RS06660	COG0088	Forms part of the polypeptide exit tunnel
C4N20_RS06665	COG0089	rRNA binding
C4N20_RS06670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4N20_RS06675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4N20_RS06680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4N20_RS06685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4N20_RS06690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4N20_RS06695	COG0255	Belongs to the universal ribosomal protein uL29 family
C4N20_RS06700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4N20_RS06705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4N20_RS06715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4N20_RS06720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4N20_RS06725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4N20_RS06730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4N20_RS06735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4N20_RS06740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4N20_RS06745	COG1841	ribosomal large subunit assembly
C4N20_RS06750	COG0200	Binds to the 23S rRNA
C4N20_RS06755	COG0201	protein transport
C4N20_RS06770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N20_RS06795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4N20_RS06805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4N20_RS06810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4N20_RS06815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4N20_RS06820	COG0202	RNA polymerase activity
C4N20_RS06825	COG0203	ribosomal protein L17
C4N20_RS06840	COG1335	isochorismatase
C4N20_RS06845	COG0052	Belongs to the universal ribosomal protein uS2 family
C4N20_RS06850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4N20_RS06855	COG0528	UMP kinase activity
C4N20_RS06860	COG0233	cytoplasmic translational termination
C4N20_RS06865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4N20_RS06870	COG4589	Belongs to the CDS family
C4N20_RS06875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4N20_RS06880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4N20_RS06885	COG0750	zinc metalloprotease
C4N20_RS06890	COG2204	response regulator
C4N20_RS06900	COG0358	DNA primase activity
C4N20_RS06905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N20_RS06950	COG0778	Nitroreductase
C4N20_RS06970	COG0335	large ribosomal subunit rRNA binding
C4N20_RS06975	COG0681	Belongs to the peptidase S26 family
C4N20_RS06985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4N20_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N20_RS07000	COG2226	methyltransferase
C4N20_RS07035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4N20_RS07045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4N20_RS07090	COG0456	acetyltransferase
C4N20_RS07090	COG1846	Transcriptional regulator
C4N20_RS07110	COG2731	YhcH YjgK YiaL family protein
C4N20_RS07115	COG2271	Major facilitator Superfamily
C4N20_RS07130	COG1115	amino acid carrier protein
C4N20_RS07135	COG1349	DNA-binding transcription factor activity
C4N20_RS07140	COG3142	Participates in the control of copper homeostasis
C4N20_RS07165	COG4721	ABC-type cobalt transport system, permease component
C4N20_RS07170	COG1122	ATPase activity
C4N20_RS07175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4N20_RS07180	COG1811	Na channel or pump
C4N20_RS07195	COG0436	Aminotransferase
C4N20_RS07200	COG0371	Dehydrogenase
C4N20_RS07210	COG0747	negative chemotaxis
C4N20_RS07220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N20_RS07225	COG0444	Belongs to the ABC transporter superfamily
C4N20_RS07230	COG4608	Belongs to the ABC transporter superfamily
C4N20_RS07240	COG1794	racemase activity, acting on amino acids and derivatives
C4N20_RS07275	COG1420	regulation of RNA biosynthetic process
C4N20_RS07285	COG0443	Heat shock 70 kDa protein
C4N20_RS07300	COG0484	heat shock protein binding
C4N20_RS07310	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4N20_RS07320	COG2188	Transcriptional regulator
C4N20_RS07325	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N20_RS07330	COG3119	arylsulfatase activity
C4N20_RS07340	COG1940	carbohydrate kinase activity
C4N20_RS07345	COG2222	sugar isomerase
C4N20_RS07355	COG1105	Belongs to the carbohydrate kinase PfkB family
C4N20_RS07370	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4N20_RS07375	COG0557	exoribonuclease II activity
C4N20_RS07380	COG0667	Aldo Keto reductase
C4N20_RS07390	COG1473	amidohydrolase
C4N20_RS07400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N20_RS07405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N20_RS07410	COG1757	Na H antiporter
C4N20_RS07425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4N20_RS07430	COG1104	cysteine desulfurase activity
C4N20_RS07435	COG0822	iron-sulfur transferase activity
C4N20_RS07440	COG1686	Belongs to the peptidase S11 family
C4N20_RS07475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4N20_RS07490	COG2268	Band 7 protein
C4N20_RS07495	COG3279	Response regulator of the LytR AlgR family
C4N20_RS07500	COG3275	phosphorelay sensor kinase activity
C4N20_RS07505	COG1966	Carbon starvation protein
C4N20_RS07540	COG1475	DNA binding
C4N20_RS07555	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C4N20_RS07560	COG0295	cytidine deaminase activity
C4N20_RS07565	COG0813	purine-nucleoside phosphorylase activity
C4N20_RS07600	COG0010	Belongs to the arginase family
C4N20_RS07610	COG0604	alcohol dehydrogenase
C4N20_RS07615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4N20_RS07620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4N20_RS07625	COG0730	response to heat
C4N20_RS07640	COG0412	Dienelactone hydrolase
C4N20_RS07645	COG2188	Transcriptional regulator
C4N20_RS07650	COG1301	dicarboxylic acid transport
C4N20_RS07660	COG3829	transcription factor binding
C4N20_RS07660	COG3290	protein histidine kinase activity
C4N20_RS07670	COG2610	gluconate transmembrane transporter activity
C4N20_RS07675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4N20_RS07700	COG0516	GMP reductase activity
C4N20_RS07700	COG0517	IMP dehydrogenase activity
C4N20_RS07725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4N20_RS07735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4N20_RS07740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4N20_RS07745	COG0517	IMP dehydrogenase activity
C4N20_RS07745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4N20_RS07770	COG1773	rubredoxin
C4N20_RS07780	COG3592	Divergent 4Fe-4S mono-cluster
C4N20_RS07810	COG0776	regulation of translation
C4N20_RS07820	COG0456	acetyltransferase
C4N20_RS07830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4N20_RS07835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4N20_RS07840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4N20_RS07845	COG1454	alcohol dehydrogenase
C4N20_RS07855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N20_RS07860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N20_RS07870	COG1609	Transcriptional regulator
C4N20_RS07875	COG1129	ABC transporter
C4N20_RS07895	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4N20_RS07895	COG3951	Flagellar rod assembly protein muramidase FlgJ
C4N20_RS07905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4N20_RS07915	COG0561	phosphatase activity
C4N20_RS07920	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C4N20_RS07925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4N20_RS07930	COG0110	maltose O-acetyltransferase activity
C4N20_RS07935	COG0583	DNA-binding transcription factor activity
C4N20_RS07975	COG0789	Transcriptional regulator
C4N20_RS07995	COG3842	ATPase activity
C4N20_RS08025	COG0243	molybdopterin cofactor binding
C4N20_RS08035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4N20_RS08045	COG0303	'Molybdopterin
C4N20_RS08065	COG4166	transmembrane transport
C4N20_RS08070	COG0601	transmembrane transport
C4N20_RS08075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N20_RS08080	COG0444	Belongs to the ABC transporter superfamily
C4N20_RS08085	COG4608	Belongs to the ABC transporter superfamily
C4N20_RS08100	COG1846	Transcriptional regulator
C4N20_RS08100	COG0456	acetyltransferase
C4N20_RS08110	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4N20_RS08120	COG0534	Mate efflux family protein
C4N20_RS08130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4N20_RS08150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4N20_RS08155	COG0716	FMN binding
C4N20_RS08160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4N20_RS08165	COG1609	Transcriptional regulator
C4N20_RS08170	COG1879	ABC-type sugar transport system periplasmic component
C4N20_RS08175	COG1129	ABC transporter
C4N20_RS08180	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4N20_RS08190	COG0673	inositol 2-dehydrogenase activity
C4N20_RS08200	COG1032	radical SAM domain protein
C4N20_RS08205	COG1032	radical SAM domain protein
C4N20_RS08220	COG1032	radical SAM domain protein
C4N20_RS08225	COG1032	radical SAM domain protein
C4N20_RS08235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4N20_RS08240	COG2868	ribosomal protein
C4N20_RS08245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4N20_RS08250	COG0583	DNA-binding transcription factor activity
C4N20_RS08260	COG1757	Na H antiporter
C4N20_RS08270	COG2723	6-phospho-beta-galactosidase activity
C4N20_RS08285	COG0700	Nucleoside recognition
C4N20_RS08290	COG3366	ferrous iron transmembrane transporter activity
C4N20_RS08305	COG3829	transcription factor binding
C4N20_RS08320	COG1757	Na H antiporter
C4N20_RS08325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS08335	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C4N20_RS08345	COG0583	DNA-binding transcription factor activity
C4N20_RS08355	COG1732	Glycine betaine
C4N20_RS08365	COG2031	fatty acid transporter
C4N20_RS08370	COG3246	L-lysine catabolic process to acetate
C4N20_RS08375	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4N20_RS08380	COG2204	response regulator
C4N20_RS08385	COG0583	DNA-binding transcription factor activity
C4N20_RS08390	COG1288	antiporter activity
C4N20_RS08405	COG3052	prosthetic group binding
C4N20_RS08415	COG3051	citrate lyase alpha subunit
C4N20_RS08420	COG1757	Na H antiporter
C4N20_RS08435	COG0110	maltose O-acetyltransferase activity
C4N20_RS08455	COG1737	Transcriptional regulator
C4N20_RS08460	COG1263	PTS System
C4N20_RS08460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS08465	COG1486	melibiose metabolic process
C4N20_RS08470	COG0371	Dehydrogenase
C4N20_RS08485	COG1408	metallophosphoesterase
C4N20_RS08495	COG2066	Belongs to the glutaminase family
C4N20_RS08500	COG1115	amino acid carrier protein
C4N20_RS08520	COG1129	ABC transporter
C4N20_RS08525	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4N20_RS08550	COG1122	ATPase activity
C4N20_RS08575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N20_RS08580	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4N20_RS08585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4N20_RS08590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4N20_RS08600	COG5002	protein histidine kinase activity
C4N20_RS08605	COG0745	RESPONSE REGULATOR receiver
C4N20_RS08610	COG2204	response regulator
C4N20_RS08620	COG0739	heme binding
C4N20_RS08630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4N20_RS08635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4N20_RS08635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4N20_RS08640	COG0307	riboflavin synthase, alpha
C4N20_RS08645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4N20_RS08645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4N20_RS08650	COG0564	pseudouridine synthase activity
C4N20_RS08655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4N20_RS08660	COG0792	nuclease activity
C4N20_RS08670	COG1040	competence protein
C4N20_RS08680	COG0149	triose-phosphate isomerase activity
C4N20_RS08690	COG1757	Na H antiporter
C4N20_RS08700	COG1757	Na H antiporter
C4N20_RS08710	COG0786	glutamate:sodium symporter activity
C4N20_RS08715	COG0583	DNA-binding transcription factor activity
C4N20_RS08720	COG0012	GTP binding
C4N20_RS08730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4N20_RS08735	COG0416	fatty acid biosynthetic process
C4N20_RS08740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4N20_RS08745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4N20_RS08750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4N20_RS08755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4N20_RS08760	COG0571	ribonuclease III activity
C4N20_RS08770	COG1530	ribonuclease E activity
C4N20_RS08775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4N20_RS08780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4N20_RS08785	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4N20_RS08795	COG0385	Bile acid
C4N20_RS08800	COG0371	Dehydrogenase
C4N20_RS08805	COG1132	(ABC) transporter
C4N20_RS08815	COG1278	Cold shock
C4N20_RS08820	COG0534	Mate efflux family protein
C4N20_RS08840	COG1414	Transcriptional regulator
C4N20_RS08845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4N20_RS08850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N20_RS08850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4N20_RS08855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N20_RS08855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4N20_RS08860	COG4948	Mandelate Racemase Muconate Lactonizing
C4N20_RS08880	COG3246	L-lysine catabolic process to acetate
C4N20_RS08885	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4N20_RS08920	COG0850	regulation of cytokinetic process
C4N20_RS08925	COG2894	cell division
C4N20_RS08930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4N20_RS08950	COG0561	phosphatase activity
C4N20_RS08955	COG2814	Major facilitator Superfamily
C4N20_RS08960	COG1566	PFAM secretion protein HlyD family protein
C4N20_RS08965	COG1538	Outer membrane efflux protein
C4N20_RS08980	COG0534	Mate efflux family protein
C4N20_RS08990	COG0110	maltose O-acetyltransferase activity
C4N20_RS08995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N20_RS09000	COG1555	photosystem II stabilization
C4N20_RS09000	COG1596	polysaccharide export
C4N20_RS09010	COG0084	hydrolase, TatD family'
C4N20_RS09015	COG2226	methyltransferase
C4N20_RS09020	COG0736	holo-[acyl-carrier-protein] synthase activity
C4N20_RS09035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4N20_RS09050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4N20_RS09055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4N20_RS09060	COG0009	L-threonylcarbamoyladenylate synthase
C4N20_RS09070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4N20_RS09080	COG0180	Tryptophanyl-tRNA synthetase
C4N20_RS09085	COG1940	carbohydrate kinase activity
C4N20_RS09095	COG1129	ABC transporter
C4N20_RS09120	COG3708	Transcriptional regulator
C4N20_RS09120	COG2207	Transcriptional regulator
C4N20_RS09125	COG0504	CTP synthase activity
C4N20_RS09130	COG1032	radical SAM domain protein
C4N20_RS09135	COG1160	GTP binding
C4N20_RS09140	COG0346	lactoylglutathione lyase activity
C4N20_RS09145	COG3395	kinase activity
C4N20_RS09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N20_RS09155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4N20_RS09175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4N20_RS09180	COG1454	alcohol dehydrogenase
C4N20_RS09185	COG1802	Transcriptional regulator
C4N20_RS09195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4N20_RS09210	COG3964	amidohydrolase
C4N20_RS09250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4N20_RS09260	COG0511	ligase activity, forming carbon-carbon bonds
C4N20_RS09265	COG0439	Biotin carboxylase
C4N20_RS09270	COG1302	Protein conserved in bacteria
C4N20_RS09285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4N20_RS09300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C4N20_RS09310	COG1704	LemA family
C4N20_RS09325	COG1285	pathogenesis
C4N20_RS09340	COG1285	pathogenesis
C4N20_RS09360	COG5002	protein histidine kinase activity
C4N20_RS09365	COG0745	RESPONSE REGULATOR receiver
C4N20_RS09370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4N20_RS09375	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C4N20_RS09380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4N20_RS09400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4N20_RS09405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4N20_RS09420	COG1366	Belongs to the anti-sigma-factor antagonist family
C4N20_RS09425	COG1418	mRNA catabolic process
C4N20_RS09430	COG1692	metallophosphoesterase
C4N20_RS09435	COG2264	protein methyltransferase activity
C4N20_RS09440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4N20_RS09445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4N20_RS09445	COG1519	Transferase
C4N20_RS09450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4N20_RS09450	COG1519	Transferase
C4N20_RS09455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4N20_RS09460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C4N20_RS09465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4N20_RS09470	COG0228	four-way junction DNA binding
C4N20_RS09475	COG2183	response to ionizing radiation
C4N20_RS09480	COG5002	protein histidine kinase activity
C4N20_RS09485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4N20_RS09490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4N20_RS09495	COG0752	glycyl-tRNA synthetase alpha subunit
C4N20_RS09500	COG0751	glycine-tRNA ligase activity
C4N20_RS09510	COG0302	gtp cyclohydrolase
C4N20_RS09515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4N20_RS09515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4N20_RS09530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4N20_RS09580	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4N20_RS09590	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C4N20_RS09595	COG1846	Transcriptional regulator
C4N20_RS09595	COG1940	carbohydrate kinase activity
C4N20_RS09600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N20_RS09605	COG1473	amidohydrolase
C4N20_RS09675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N20_RS09680	COG2056	Na+-H+ antiporter family
C4N20_RS09685	COG2986	histidine ammonia-lyase
C4N20_RS09690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4N20_RS09695	COG1228	amidohydrolase
C4N20_RS09710	COG2378	regulation of single-species biofilm formation
C4N20_RS09715	COG0251	oxidation-reduction process
C4N20_RS09725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS09735	COG3829	transcription factor binding
C4N20_RS09740	COG0402	S-adenosylhomocysteine deaminase activity
C4N20_RS09745	COG2233	PERMEase
C4N20_RS09750	COG0167	dihydroorotate dehydrogenase activity
C4N20_RS09770	COG0776	regulation of translation
C4N20_RS09800	COG0747	negative chemotaxis
C4N20_RS09805	COG1811	Na channel or pump
C4N20_RS09810	COG0561	phosphatase activity
C4N20_RS09820	COG5002	protein histidine kinase activity
C4N20_RS09845	COG1473	amidohydrolase
C4N20_RS09860	COG3118	belongs to the thioredoxin family
C4N20_RS09865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N20_RS09880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C4N20_RS09885	COG0574	Belongs to the PEP-utilizing enzyme family
C4N20_RS09885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4N20_RS09890	COG0517	IMP dehydrogenase activity
C4N20_RS09895	COG0622	Phosphoesterase
C4N20_RS09900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4N20_RS09940	COG0606	chelatase, subunit chli
C4N20_RS09945	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS09950	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS09955	COG1144	Oxidoreductase
C4N20_RS09960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4N20_RS09965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N20_RS09970	COG1971	Probably functions as a manganese efflux pump
C4N20_RS09975	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4N20_RS10010	COG3842	ATPase activity
C4N20_RS10015	COG1840	ABC-type Fe3 transport system, periplasmic component
C4N20_RS10020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4N20_RS10030	COG1115	amino acid carrier protein
C4N20_RS10035	COG4565	transcriptional regulatory protein
C4N20_RS10040	COG2205	protein histidine kinase activity
C4N20_RS10045	COG0405	Gamma-glutamyltransferase
C4N20_RS10050	COG0405	Gamma-glutamyltransferase
C4N20_RS10065	COG3608	succinylglutamate desuccinylase aspartoacylase
C4N20_RS10075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4N20_RS10095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4N20_RS10100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4N20_RS10105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N20_RS10130	COG0811	peptide transport
C4N20_RS10135	COG0848	biopolymer transport protein
C4N20_RS10145	COG2204	response regulator
C4N20_RS10150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4N20_RS10160	COG0359	binds to the 23S rRNA
C4N20_RS10165	COG0305	Participates in initiation and elongation during chromosome replication
C4N20_RS10170	COG0826	peptidase U32
C4N20_RS10175	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N20_RS10180	COG3119	arylsulfatase activity
C4N20_RS10210	COG0745	RESPONSE REGULATOR receiver
C4N20_RS10215	COG5002	protein histidine kinase activity
C4N20_RS10230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4N20_RS10235	COG2610	gluconate transmembrane transporter activity
C4N20_RS10240	COG0583	DNA-binding transcription factor activity
C4N20_RS10250	COG2030	dehydratase
C4N20_RS10255	COG1960	acyl-CoA dehydrogenase activity
C4N20_RS10260	COG2086	electron transfer activity
C4N20_RS10265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4N20_RS10270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4N20_RS10295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4N20_RS10305	COG2070	2-Nitropropane dioxygenase
C4N20_RS10310	COG0583	DNA-binding transcription factor activity
C4N20_RS10325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4N20_RS10330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4N20_RS10335	COG0426	domain, Protein
C4N20_RS10335	COG1773	rubredoxin
C4N20_RS10360	COG1733	regulation of RNA biosynthetic process
C4N20_RS10390	COG5001	Diguanylate cyclase
C4N20_RS10410	COG3300	MHYT domain
C4N20_RS10410	COG5001	Diguanylate cyclase
C4N20_RS10415	COG4213	ABC transporter substrate-binding protein
C4N20_RS10425	COG4807	Protein conserved in bacteria
C4N20_RS10455	COG1136	(ABC) transporter
C4N20_RS10460	COG0577	efflux transmembrane transporter activity
C4N20_RS10470	COG0429	hydrolase of the alpha beta-hydrolase fold
C4N20_RS10480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4N20_RS10495	COG1490	D-aminoacyl-tRNA deacylase activity
C4N20_RS10500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4N20_RS10505	COG1803	Methylglyoxal synthase
C4N20_RS10510	COG0688	phosphatidylethanolamine metabolic process
C4N20_RS10535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4N20_RS10545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4N20_RS10550	COG0747	negative chemotaxis
C4N20_RS10555	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C4N20_RS10575	COG0406	alpha-ribazole phosphatase activity
C4N20_RS10585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4N20_RS10590	COG2385	sporulation resulting in formation of a cellular spore
C4N20_RS10610	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N20_RS10625	COG1982	Orn Lys Arg decarboxylase major
C4N20_RS10645	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4N20_RS10660	COG0745	RESPONSE REGULATOR receiver
C4N20_RS10665	COG5002	protein histidine kinase activity
C4N20_RS10720	COG1690	Belongs to the RtcB family
C4N20_RS10745	COG1473	amidohydrolase
C4N20_RS10765	COG1846	Transcriptional regulator
C4N20_RS10785	COG2848	UPF0210 protein
C4N20_RS10790	COG0534	Mate efflux family protein
C4N20_RS10800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4N20_RS10805	COG0154	amidase activity
C4N20_RS10810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4N20_RS10815	COG1187	pseudouridine synthase activity
C4N20_RS10820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4N20_RS10830	COG1077	Cell shape determining protein MreB Mrl
C4N20_RS10835	COG0424	maF-like protein
C4N20_RS10850	COG1295	ribonuclease BN
C4N20_RS10865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4N20_RS10865	COG0248	Ppx GppA phosphatase
C4N20_RS10905	COG0632	four-way junction helicase activity
C4N20_RS10915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N20_RS10940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4N20_RS10945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4N20_RS10960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4N20_RS10970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N20_RS10990	COG1696	Membrane protein involved in D-alanine export
C4N20_RS11000	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C4N20_RS11005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4N20_RS11015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4N20_RS11020	COG2003	Belongs to the UPF0758 family
C4N20_RS11025	COG1774	PSP1 C-terminal conserved region
C4N20_RS11040	COG2252	PERMEase
C4N20_RS11045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4N20_RS11050	COG3829	transcription factor binding
C4N20_RS11070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4N20_RS11080	COG0428	transporter
C4N20_RS11095	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS11095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4N20_RS11095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4N20_RS11095	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS11100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4N20_RS11105	COG0280	phosphate acetyltransferase
C4N20_RS11110	COG0552	protein localization to endoplasmic reticulum
C4N20_RS11125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N20_RS11130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4N20_RS11135	COG4974	Belongs to the 'phage' integrase family
C4N20_RS11140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C4N20_RS11145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4N20_RS11150	COG0758	DNA mediated transformation
C4N20_RS11160	COG1570	exodeoxyribonuclease VII activity
C4N20_RS11165	COG0556	nucleotide-excision repair
C4N20_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
C4N20_RS11200	COG0800	Aldolase
C4N20_RS11205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4N20_RS11210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N20_RS11215	COG0438	transferase activity, transferring glycosyl groups
C4N20_RS11220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4N20_RS11240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N20_RS11255	COG1216	Glycosyl transferase, family 2
C4N20_RS11270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4N20_RS11280	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4N20_RS11300	COG3274	enterobacterial common antigen metabolic process
C4N20_RS11305	COG3620	sequence-specific DNA binding
C4N20_RS11320	COG0768	penicillin binding
C4N20_RS11325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4N20_RS11330	COG0242	peptide deformylase activity
C4N20_RS11340	COG1494	fructose-1,6-bisphosphatase
C4N20_RS11345	COG1115	amino acid carrier protein
C4N20_RS11350	COG3033	Beta-eliminating lyase
C4N20_RS11355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N20_RS11420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N20_RS11425	COG0463	Glycosyl transferase, family 2
C4N20_RS11425	COG1216	Glycosyl transferase, family 2
C4N20_RS11430	COG0438	transferase activity, transferring glycosyl groups
C4N20_RS11440	COG0438	transferase activity, transferring glycosyl groups
C4N20_RS11445	COG1216	Glycosyl transferase, family 2
C4N20_RS11460	COG5002	protein histidine kinase activity
C4N20_RS11465	COG0745	RESPONSE REGULATOR receiver
C4N20_RS11470	COG0463	Glycosyl transferase, family 2
C4N20_RS11480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4N20_RS11490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4N20_RS11505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N20_RS11510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4N20_RS11580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4N20_RS11585	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4N20_RS11595	COG3842	ATPase activity
C4N20_RS11600	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4N20_RS11605	COG1177	transmembrane transport
C4N20_RS11610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4N20_RS11635	COG0436	Aminotransferase
C4N20_RS11655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4N20_RS11665	COG0167	dihydroorotate dehydrogenase activity
C4N20_RS11670	COG0543	2 iron, 2 sulfur cluster binding
C4N20_RS11675	COG0540	Belongs to the ATCase OTCase family
C4N20_RS11695	COG3852	Histidine kinase
C4N20_RS11700	COG2204	response regulator
C4N20_RS11705	COG1757	Na H antiporter
C4N20_RS11710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C4N20_RS11750	COG0598	Magnesium transport protein CorA
C4N20_RS11760	COG1199	ATP-dependent helicase activity
C4N20_RS11765	COG1480	7TM receptor with intracellular HD hydrolase
C4N20_RS11770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4N20_RS11775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4N20_RS11790	COG0183	Belongs to the thiolase family
C4N20_RS11795	COG1024	Enoyl-CoA hydratase
C4N20_RS11800	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4N20_RS11805	COG1053	succinate dehydrogenase
C4N20_RS11805	COG0431	NADPH-dependent FMN reductase
C4N20_RS11805	COG3976	FMN-binding domain protein
C4N20_RS11815	COG0268	Binds directly to 16S ribosomal RNA
C4N20_RS11820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4N20_RS11835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4N20_RS11840	COG1309	transcriptional regulator
C4N20_RS11845	COG0010	Belongs to the arginase family
C4N20_RS11850	COG0786	glutamate:sodium symporter activity
C4N20_RS11865	COG0667	Aldo Keto reductase
C4N20_RS11870	COG0789	Transcriptional regulator
C4N20_RS11880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4N20_RS11885	COG0346	lactoylglutathione lyase activity
C4N20_RS11890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4N20_RS11905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4N20_RS11920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4N20_RS11925	COG0124	histidyl-tRNA synthetase
C4N20_RS11930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4N20_RS11935	COG0018	arginyl-trna synthetase
C4N20_RS11940	COG1660	Displays ATPase and GTPase activities
C4N20_RS11945	COG0322	excinuclease ABC activity
C4N20_RS11955	COG2208	phosphoserine phosphatase activity
C4N20_RS11960	COG3872	metal-dependent enzyme
C4N20_RS11970	COG1489	DNA binding
C4N20_RS11980	COG5001	Diguanylate cyclase
C4N20_RS11980	COG3706	GGDEF domain
C4N20_RS11980	COG2203	Gaf domain
C4N20_RS11980	COG4251	negative regulation of phosphorylation
C4N20_RS12000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4N20_RS12005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4N20_RS12020	COG0534	Mate efflux family protein
C4N20_RS12025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4N20_RS12035	COG1121	(ABC) transporter
C4N20_RS12055	COG2996	Protein conserved in bacteria
C4N20_RS12075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4N20_RS12080	COG1162	GTPase activity
C4N20_RS12095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4N20_RS12110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4N20_RS12115	COG0336	Belongs to the RNA methyltransferase TrmD family
C4N20_RS12125	COG4752	Belongs to the RNA methyltransferase TrmD family
C4N20_RS12145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4N20_RS12155	COG2853	Lipoprotein
C4N20_RS12160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N20_RS12200	COG1192	Involved in chromosome partitioning
C4N20_RS12210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4N20_RS12235	COG3048	D-serine ammonia-lyase activity
C4N20_RS12240	COG2610	gluconate transmembrane transporter activity
C4N20_RS12290	COG1484	DNA-dependent DNA replication
C4N20_RS12325	COG4974	Belongs to the 'phage' integrase family
C4N20_RS12365	COG4626	Terminase
C4N20_RS12365	COG1802	Transcriptional regulator
C4N20_RS12375	COG0740	serine-type endopeptidase activity
C4N20_RS12450	COG3299	homolog of phage Mu protein gp47
C4N20_RS12510	COG0747	negative chemotaxis
C4N20_RS12525	COG0392	lysyltransferase activity
C4N20_RS12525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4N20_RS12530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4N20_RS12545	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4N20_RS12550	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4N20_RS12555	COG4149	molybdate abc transporter
C4N20_RS12590	COG1970	mechanosensitive ion channel activity
C4N20_RS12615	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4N20_RS12620	COG1129	ABC transporter
C4N20_RS12625	COG1869	D-ribose catabolic process
C4N20_RS12635	COG1609	Transcriptional regulator
C4N20_RS12640	COG1733	regulation of RNA biosynthetic process
C4N20_RS12650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4N20_RS12670	COG0534	Mate efflux family protein
C4N20_RS12685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4N20_RS12685	COG0456	acetyltransferase
C4N20_RS12715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4N20_RS12720	COG0494	nUDIX hydrolase
C4N20_RS12725	COG2962	Rard protein
C4N20_RS12735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4N20_RS12745	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4N20_RS12750	COG1278	Cold shock
C4N20_RS12785	COG1595	DNA-templated transcription, initiation
C4N20_RS12790	COG1757	Na H antiporter
C4N20_RS12860	COG0776	regulation of translation
C4N20_RS12865	COG0776	regulation of translation
C4N20_RS12920	COG0671	phosphoesterase, PA-phosphatase related
C4N20_RS12935	COG3706	GGDEF domain
C4N20_RS12955	COG1278	Cold shock
C4N20_RS12995	COG0531	amino acid
C4N20_RS13000	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4N20_RS13010	COG5001	Diguanylate cyclase
C4N20_RS13015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N20_RS13020	COG3829	transcription factor binding
C4N20_RS13020	COG3290	protein histidine kinase activity
C4N20_RS13030	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4N20_RS13035	COG1301	dicarboxylic acid transport
C4N20_RS13060	COG1691	(AIR) carboxylase
C4N20_RS13065	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4N20_RS13070	COG1606	tRNA processing
C4N20_RS13085	COG1122	ATPase activity
C4N20_RS13105	COG0469	pyruvate kinase activity
C4N20_RS13110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4N20_RS13120	COG1960	acyl-CoA dehydrogenase activity
C4N20_RS13125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4N20_RS13135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4N20_RS13140	COG1144	Oxidoreductase
C4N20_RS13145	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS13150	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4N20_RS13155	COG3706	GGDEF domain
C4N20_RS13165	COG1342	Belongs to the UPF0251 family
C4N20_RS13180	COG0629	single-stranded DNA binding
C4N20_RS13185	COG0776	regulation of translation
C4N20_RS13200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N20_RS13200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N20_RS13205	COG1481	regulation of sporulation
C4N20_RS13210	COG0196	riboflavin kinase activity
C4N20_RS13215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4N20_RS13220	COG0728	peptidoglycan biosynthetic process
C4N20_RS13230	COG0598	Magnesium transport protein CorA
C4N20_RS13250	COG5001	Diguanylate cyclase
C4N20_RS13250	COG1716	ATPase activity
C4N20_RS13255	COG5001	Diguanylate cyclase
C4N20_RS13255	COG3300	MHYT domain
C4N20_RS13270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4N20_RS13280	COG2203	Gaf domain
C4N20_RS13280	COG2199	diguanylate cyclase activity
C4N20_RS13285	COG1115	amino acid carrier protein
C4N20_RS13290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4N20_RS13300	COG2022	thiamine diphosphate biosynthetic process
C4N20_RS13315	COG0352	thiamine-phosphate diphosphorylase activity
C4N20_RS13345	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4N20_RS13375	COG1053	succinate dehydrogenase
C4N20_RS13380	COG3069	C4-dicarboxylate transmembrane transporter activity
C4N20_RS13385	COG1473	amidohydrolase
C4N20_RS13390	COG4948	Mandelate Racemase Muconate Lactonizing
C4N20_RS13410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4N20_RS13420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4N20_RS13425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4N20_RS13430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4N20_RS13435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4N20_RS13440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4N20_RS13445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4N20_RS13450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4N20_RS13455	COG0138	bifunctional purine biosynthesis protein purh
C4N20_RS13460	COG0151	Belongs to the GarS family
C4N20_RS13470	COG2814	Major facilitator Superfamily
C4N20_RS13530	COG0776	regulation of translation
C4N20_RS13535	COG0776	regulation of translation
C4N20_RS13540	COG5012	cobalamin binding
C4N20_RS13560	COG0726	polysaccharide deacetylase
C4N20_RS13565	COG2309	aminopeptidase activity
C4N20_RS13580	COG5001	Diguanylate cyclase
C4N20_RS13595	COG0561	phosphatase activity
C4N20_RS13600	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4N20_RS13605	COG1687	branched-chain amino acid
C4N20_RS13615	COG0534	Mate efflux family protein
C4N20_RS13620	COG1671	Belongs to the UPF0178 family
C4N20_RS13625	COG0393	Putative heavy-metal-binding
C4N20_RS13640	COG2030	dehydratase
C4N20_RS13645	COG3246	L-lysine catabolic process to acetate
C4N20_RS13650	COG2610	gluconate transmembrane transporter activity
C4N20_RS13660	COG3829	transcription factor binding
C4N20_RS13705	COG1716	ATPase activity
C4N20_RS13795	COG3192	ethanolamine utilization protein
C4N20_RS13805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4N20_RS13820	COG1473	amidohydrolase
C4N20_RS13830	COG4974	Belongs to the 'phage' integrase family
C4N20_RS13840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4N20_RS13845	COG1979	alcohol dehydrogenase
C4N20_RS13880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4N20_RS13900	COG1187	pseudouridine synthase activity
C4N20_RS13905	COG4974	Belongs to the 'phage' integrase family
C4N20_RS13910	COG0384	phenazine biosynthesis protein PhzF
C4N20_RS13915	COG1659	Linocin_M18 bacteriocin protein
C4N20_RS13925	COG0363	glucosamine-6-phosphate deaminase activity
C4N20_RS13930	COG1242	4 iron, 4 sulfur cluster binding
C4N20_RS13940	COG2045	Belongs to the ComB family
C4N20_RS13945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N20_RS13950	COG1126	abc transporter atp-binding protein
C4N20_RS13955	COG0765	amino acid transport
C4N20_RS13960	COG2502	aspartate--ammonia ligase
C4N20_RS13975	COG4978	Transcriptional regulator
C4N20_RS13975	COG0789	Transcriptional regulator
C4N20_RS13980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4N20_RS13995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4N20_RS14015	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4N20_RS14020	COG0683	leucine binding
C4N20_RS14025	COG2388	GCN5-related N-acetyl-transferase
C4N20_RS14045	COG0747	negative chemotaxis
C4N20_RS14050	COG1363	Peptidase, m42
C4N20_RS14080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4N20_RS14090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4N20_RS14095	COG0527	aspartate kinase activity
C4N20_RS14100	COG0460	homoserine dehydrogenase
C4N20_RS14115	COG4492	Belongs to the UPF0735 family
C4N20_RS14120	COG1263	PTS System
C4N20_RS14120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS14120	COG2190	(PTS) system
C4N20_RS14135	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4N20_RS14140	COG1518	maintenance of DNA repeat elements
C4N20_RS14195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4N20_RS14205	COG0210	DNA helicase
C4N20_RS14230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4N20_RS14235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4N20_RS14240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4N20_RS14265	COG0564	pseudouridine synthase activity
C4N20_RS14320	COG0583	DNA-binding transcription factor activity
C4N20_RS14345	COG4221	oxidoreductase activity
C4N20_RS14350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4N20_RS14355	COG0252	asparaginase activity
C4N20_RS14360	COG1027	Aspartate ammonia-lyase
C4N20_RS14365	COG3119	arylsulfatase activity
C4N20_RS14370	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N20_RS14380	COG0714	Associated with various cellular activities
C4N20_RS14395	COG2304	oxidoreductase activity
C4N20_RS14420	COG3706	GGDEF domain
C4N20_RS14425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4N20_RS14430	COG0402	S-adenosylhomocysteine deaminase activity
C4N20_RS14440	COG0006	proline dipeptidase activity
C4N20_RS14445	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C4N20_RS14455	COG0456	acetyltransferase
C4N20_RS14460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4N20_RS14470	COG3012	SEC-C Motif Domain Protein
C4N20_RS14485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4N20_RS14495	COG1132	(ABC) transporter
C4N20_RS14520	COG4977	sequence-specific DNA binding
C4N20_RS14525	COG2832	Protein of unknown function (DUF454)
C4N20_RS14535	COG1120	ATPase activity
C4N20_RS14540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N20_RS14545	COG4771	TonB-dependent receptor
C4N20_RS14550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N20_RS14560	COG1120	ATPase activity
C4N20_RS14565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N20_RS14570	COG4771	TonB-dependent receptor
C4N20_RS14575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N20_RS14585	COG0811	peptide transport
C4N20_RS14590	COG0848	biopolymer transport protein
C4N20_RS14600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N20_RS14600	COG1263	PTS System
C4N20_RS14630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N20_RS14735	COG0351	phosphomethylpyrimidine kinase
C4N20_RS14735	COG0352	thiamine-phosphate diphosphorylase activity
C4N20_RS14745	COG0708	Exodeoxyribonuclease III
C4N20_RS14755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4N20_RS14770	COG3842	ATPase activity
C4N20_RS14780	COG1840	ABC-type Fe3 transport system, periplasmic component
C4N20_RS14785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4N20_RS14815	COG2080	2 iron, 2 sulfur cluster binding
C4N20_RS14815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4N20_RS14820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4N20_RS14825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N20_RS14830	COG0765	amino acid transport
C4N20_RS14835	COG1126	abc transporter atp-binding protein
C4N20_RS14840	COG1131	(ABC) transporter
C4N20_RS14860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4N20_RS14865	COG0668	transmembrane transport
C4N20_RS14875	COG1982	Orn Lys Arg decarboxylase major
C4N20_RS14880	COG0504	CTP synthase activity
C4N20_RS14885	COG1047	Peptidyl-prolyl cis-trans
C4N20_RS14890	COG0698	ribose 5-phosphate isomerase
C4N20_RS14895	COG0537	adenosine 5'-monophosphoramidase activity
C4N20_RS14900	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N20_RS14905	COG1228	amidohydrolase
C4N20_RS14910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4N20_RS14915	COG1473	amidohydrolase
C4N20_RS14940	COG0668	transmembrane transport
C4N20_RS15020	COG1011	Hydrolase
C4N20_RS15025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4N20_RS15035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C4N20_RS15095	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4N20_RS15105	COG1797	cobyrinic acid a,c-diamide synthase activity
C4N20_RS15110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4N20_RS15120	COG1492	cobalamin metabolic process
C4N20_RS15130	COG0673	inositol 2-dehydrogenase activity
C4N20_RS15205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C4N20_RS15215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4N20_RS15225	COG0017	Asparaginyl-tRNA synthetase
C4N20_RS15230	COG4224	UPF0291 protein
C4N20_RS15235	COG0772	Belongs to the SEDS family
C4N20_RS15265	COG1799	cell septum assembly
C4N20_RS15280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4N20_RS15290	COG0285	dihydrofolate synthase activity
C4N20_RS15295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4N20_RS15310	COG0481	GTPase activity
C4N20_RS15335	COG2376	Dihydroxyacetone kinase
C4N20_RS15345	COG0251	oxidation-reduction process
C4N20_RS15350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4N20_RS15350	COG3608	succinylglutamate desuccinylase aspartoacylase
C4N20_RS15355	COG3608	succinylglutamate desuccinylase aspartoacylase
C4N20_RS15355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4N20_RS15390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4N20_RS15395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N20_RS15440	COG4221	oxidoreductase activity
C4N20_RS15455	COG5012	cobalamin binding
C4N20_RS15460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4N20_RS15465	COG1193	negative regulation of DNA recombination
C4N20_RS15475	COG1509	lysine 2,3-aminomutase activity
C4N20_RS15480	COG0604	alcohol dehydrogenase
C4N20_RS15485	COG3246	L-lysine catabolic process to acetate
C4N20_RS15490	COG1607	acyl-coa hydrolase
C4N20_RS15510	COG0384	phenazine biosynthesis protein PhzF
C4N20_RS15535	COG0482	sulfurtransferase activity
C4N20_RS15545	COG1151	hydroxylamine reductase activity
C4N20_RS15550	COG1053	succinate dehydrogenase
C4N20_RS15555	COG1053	succinate dehydrogenase
C4N20_RS15560	COG0542	response to heat
C4N20_RS15585	COG0519	Catalyzes the synthesis of GMP from XMP
C4N20_RS15585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4N20_RS15590	COG4824	toxin secretion phage lysis holin
C4N20_RS15610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4N20_RS15730	COG0740	serine-type endopeptidase activity
C4N20_RS15815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4N20_RS15860	COG1192	Involved in chromosome partitioning
C4N20_RS15865	COG0305	Participates in initiation and elongation during chromosome replication
C4N20_RS15890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4N20_RS15895	COG0656	L-ascorbic acid biosynthetic process
C4N20_RS15900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N20_RS15910	COG1120	ATPase activity
C4N20_RS15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N20_RS15920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4N20_RS15935	COG4206	TonB-dependent receptor
C4N20_RS15965	COG0848	biopolymer transport protein
C4N20_RS15970	COG0811	peptide transport
C4N20_RS15975	COG1120	ATPase activity
C4N20_RS15990	COG4822	anaerobic cobalamin biosynthetic process
C4N20_RS16010	COG1253	flavin adenine dinucleotide binding
C4N20_RS16025	COG0739	heme binding
C4N20_RS16030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N20_RS16035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4N20_RS16055	COG0659	secondary active sulfate transmembrane transporter activity
C4N20_RS16060	COG0427	acetyl-CoA hydrolase
C4N20_RS16075	COG3290	protein histidine kinase activity
C4N20_RS16075	COG3829	transcription factor binding
C4N20_RS16085	COG1683	Conserved Protein
C4N20_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
C4N20_RS16110	COG0183	Belongs to the thiolase family
C4N20_RS16125	COG2217	Heavy metal translocating P-type atpase
C4N20_RS16140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4N20_RS16155	COG0488	(ABC) transporter
C4N20_RS16160	COG0572	uridine kinase
C4N20_RS16165	COG0700	Nucleoside recognition
C4N20_RS16170	COG2715	membrane protein required for spore maturation
C4N20_RS16175	COG4608	Belongs to the ABC transporter superfamily
C4N20_RS16180	COG0444	Belongs to the ABC transporter superfamily
C4N20_RS16185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N20_RS16190	COG0601	transmembrane transport
C4N20_RS16195	COG0747	negative chemotaxis
C4N20_RS16205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4N20_RS16210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4N20_RS16215	COG0037	tRNA processing
C4N20_RS16220	COG1032	radical SAM domain protein
C4N20_RS16225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4N20_RS16230	COG0513	Belongs to the DEAD box helicase family
C4N20_RS16250	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4N20_RS16255	COG1687	branched-chain amino acid
C4N20_RS16260	COG0783	Belongs to the Dps family
C4N20_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
C4N20_RS16270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4N20_RS16275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4N20_RS16285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4N20_RS16285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4N20_RS16290	COG2239	Acts as a magnesium transporter
C4N20_RS16295	COG0326	Molecular chaperone. Has ATPase activity
C4N20_RS16320	COG0343	queuine tRNA-ribosyltransferase activity
C4N20_RS16325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4N20_RS16330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4N20_RS16345	COG1253	flavin adenine dinucleotide binding
C4N20_RS16350	COG0617	tRNA 3'-terminal CCA addition
C4N20_RS16350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4N20_RS16350	COG0517	IMP dehydrogenase activity
C4N20_RS16355	COG0511	ligase activity, forming carbon-carbon bonds
C4N20_RS16360	COG4492	Belongs to the UPF0735 family
C4N20_RS16365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4N20_RS16370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4N20_RS16375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes