locus-tag	class	description
HX109_RS00010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HX109_RS00015	COG0542	response to heat
HX109_RS00020	COG0189	ligase activity
HX109_RS00020	COG4067	protein conserved in archaea
HX109_RS00030	COG2986	histidine ammonia-lyase
HX109_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HX109_RS00040	COG0460	homoserine dehydrogenase
HX109_RS00040	COG0527	aspartate kinase activity
HX109_RS00045	COG0083	homoserine kinase activity
HX109_RS00050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HX109_RS00070	COG0668	transmembrane transport
HX109_RS00105	COG1360	Flagellar Motor Protein
HX109_RS00110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HX109_RS00120	COG0842	Transport permease protein
HX109_RS00120	COG1129	ABC transporter
HX109_RS00125	COG0842	Transport permease protein
HX109_RS00130	COG1131	(ABC) transporter
HX109_RS00135	COG1131	(ABC) transporter
HX109_RS00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HX109_RS00160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HX109_RS00170	COG0456	acetyltransferase
HX109_RS00175	COG3118	belongs to the thioredoxin family
HX109_RS00180	COG0542	response to heat
HX109_RS00185	COG1309	transcriptional regulator
HX109_RS00205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HX109_RS00220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HX109_RS00225	COG0671	phosphoesterase, PA-phosphatase related
HX109_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS00260	COG3781	membrane
HX109_RS00275	COG0124	histidyl-tRNA synthetase
HX109_RS00290	COG0359	binds to the 23S rRNA
HX109_RS00295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HX109_RS00300	COG0360	Binds together with S18 to 16S ribosomal RNA
HX109_RS00305	COG3279	Response regulator of the LytR AlgR family
HX109_RS00310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HX109_RS00320	COG3956	TIGRFAM MazG family protein
HX109_RS00345	COG0242	peptide deformylase activity
HX109_RS00355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HX109_RS00360	COG2171	N-acyltransferase activity
HX109_RS00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HX109_RS00380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HX109_RS00380	COG0463	Glycosyl transferase, family 2
HX109_RS00405	COG0517	IMP dehydrogenase activity
HX109_RS00405	COG0617	tRNA 3'-terminal CCA addition
HX109_RS00405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HX109_RS00410	COG1612	heme a metabolic process
HX109_RS00425	COG1104	cysteine desulfurase activity
HX109_RS00455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HX109_RS00480	COG2949	membrane
HX109_RS00485	COG1960	acyl-CoA dehydrogenase activity
HX109_RS00490	COG0183	Belongs to the thiolase family
HX109_RS00500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HX109_RS00500	COG1024	Enoyl-CoA hydratase
HX109_RS00510	COG1022	Amp-dependent synthetase and ligase
HX109_RS00515	COG0047	phosphoribosylformylglycinamidine synthase activity
HX109_RS00515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HX109_RS00530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HX109_RS00555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HX109_RS00560	COG0501	Belongs to the peptidase M48B family
HX109_RS00565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HX109_RS00570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HX109_RS00575	COG1056	cytidyltransferase-related domain
HX109_RS00575	COG1051	belongs to the nudix hydrolase family
HX109_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HX109_RS00595	COG1228	amidohydrolase
HX109_RS00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
HX109_RS00625	COG0745	RESPONSE REGULATOR receiver
HX109_RS00630	COG3292	Two component regulator propeller
HX109_RS00630	COG0745	RESPONSE REGULATOR receiver
HX109_RS00630	COG2205	protein histidine kinase activity
HX109_RS00650	COG0045	succinate-CoA ligase (ADP-forming) activity
HX109_RS00685	COG3387	PFAM Glycoside hydrolase 15-related
HX109_RS00690	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HX109_RS00750	COG3119	arylsulfatase activity
HX109_RS00760	COG0437	4 iron, 4 sulfur cluster binding
HX109_RS00775	COG0243	molybdopterin cofactor binding
HX109_RS00795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HX109_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HX109_RS00820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HX109_RS00825	COG0714	Associated with various cellular activities
HX109_RS00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HX109_RS00850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HX109_RS00870	COG3046	protein related to deoxyribodipyrimidine photolyase
HX109_RS00930	COG0714	Associated with various cellular activities
HX109_RS00945	COG3119	arylsulfatase activity
HX109_RS00950	COG3119	arylsulfatase activity
HX109_RS01010	COG0187	DNA topoisomerase II activity
HX109_RS01015	COG0367	asparagine synthase
HX109_RS01035	COG2988	succinylglutamate desuccinylase activity
HX109_RS01040	COG0189	ligase activity
HX109_RS01065	COG3844	kynureninase activity
HX109_RS01085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HX109_RS01095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HX109_RS01100	COG0671	phosphoesterase, PA-phosphatase related
HX109_RS01115	COG3279	Response regulator of the LytR AlgR family
HX109_RS01130	COG3275	phosphorelay sensor kinase activity
HX109_RS01140	COG1619	proteins homologs of microcin C7 resistance protein MccF
HX109_RS01155	COG0514	ATP-dependent DNA helicase (RecQ)
HX109_RS01165	COG0805	protein transport
HX109_RS01175	COG1137	ATPase activity
HX109_RS01180	COG3015	lipoprotein NlpE involved in copper resistance
HX109_RS01195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HX109_RS01200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HX109_RS01205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HX109_RS01210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HX109_RS01225	COG2326	polyphosphate kinase activity
HX109_RS01245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HX109_RS01255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HX109_RS01290	COG2890	protein-(glutamine-N5) methyltransferase activity
HX109_RS01300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HX109_RS01300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HX109_RS01305	COG1011	Hydrolase
HX109_RS01310	COG1739	Uncharacterized protein family UPF0029
HX109_RS01315	COG0824	Thioesterase
HX109_RS01320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HX109_RS01325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HX109_RS01330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HX109_RS01340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HX109_RS01350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HX109_RS01355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HX109_RS01380	COG0336	Belongs to the RNA methyltransferase TrmD family
HX109_RS01385	COG0335	large ribosomal subunit rRNA binding
HX109_RS01405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HX109_RS01425	COG0438	transferase activity, transferring glycosyl groups
HX109_RS01440	COG2181	nitrate reductase activity
HX109_RS01440	COG0247	lactate metabolic process
HX109_RS01450	COG2181	nitrate reductase activity
HX109_RS01450	COG0247	lactate metabolic process
HX109_RS01460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HX109_RS01470	COG0251	oxidation-reduction process
HX109_RS01475	COG1349	DNA-binding transcription factor activity
HX109_RS01480	COG1629	transport
HX109_RS01490	COG1649	PFAM Uncharacterised BCR, COG1649
HX109_RS01505	COG0205	6-phosphofructokinase activity
HX109_RS01515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HX109_RS01530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HX109_RS01545	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HX109_RS01550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HX109_RS01590	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HX109_RS01620	COG1566	PFAM secretion protein HlyD family protein
HX109_RS01645	COG2076	Multidrug Resistance protein
HX109_RS01660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HX109_RS01670	COG0154	amidase activity
HX109_RS01675	COG0552	protein localization to endoplasmic reticulum
HX109_RS01685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HX109_RS01690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HX109_RS01695	COG1058	Belongs to the CinA family
HX109_RS01695	COG1546	Belongs to the CinA family
HX109_RS01710	COG5002	protein histidine kinase activity
HX109_RS01710	COG2176	DNA-directed DNA polymerase activity
HX109_RS01715	COG0508	dehydrogenase complex catalyzes the overall conversion of
HX109_RS01720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HX109_RS01725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HX109_RS01800	COG3657	addiction module killer protein
HX109_RS01810	COG0305	Participates in initiation and elongation during chromosome replication
HX109_RS01815	COG0825	malonyl-CoA metabolic process
HX109_RS01830	COG0343	queuine tRNA-ribosyltransferase activity
HX109_RS01835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HX109_RS01840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HX109_RS01855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HX109_RS01860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HX109_RS01865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HX109_RS01905	COG2329	Antibiotic biosynthesis monooxygenase
HX109_RS01915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HX109_RS01955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HX109_RS01960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HX109_RS01965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HX109_RS01970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HX109_RS02035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HX109_RS02040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS02040	COG1703	isobutyryl-CoA mutase activity
HX109_RS02040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS02045	COG0788	formyltetrahydrofolate deformylase activity
HX109_RS02055	COG0284	orotidine-5'-phosphate decarboxylase activity
HX109_RS02060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HX109_RS02065	COG1629	transport
HX109_RS02080	COG0174	glutamine synthetase
HX109_RS02090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HX109_RS02120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HX109_RS02125	COG0492	ferredoxin-NADP+ reductase activity
HX109_RS02170	COG3347	Dehydrogenase
HX109_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS02175	COG4952	isomerase
HX109_RS02185	COG1304	FMN binding
HX109_RS02190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HX109_RS02200	COG2814	Major facilitator Superfamily
HX109_RS02205	COG1473	amidohydrolase
HX109_RS02210	COG2226	methyltransferase
HX109_RS02225	COG1522	sequence-specific DNA binding
HX109_RS02240	COG0488	(ABC) transporter
HX109_RS02250	COG2096	Adenosyltransferase
HX109_RS02260	COG0653	protein targeting
HX109_RS02275	COG1595	DNA-templated transcription, initiation
HX109_RS02285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HX109_RS02310	COG1538	Outer membrane efflux protein
HX109_RS02320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HX109_RS02330	COG1764	response to oxidative stress
HX109_RS02340	COG0463	Glycosyl transferase, family 2
HX109_RS02345	COG3952	Lipid A Biosynthesis
HX109_RS02345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS02375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HX109_RS02385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HX109_RS02400	COG4974	Belongs to the 'phage' integrase family
HX109_RS02405	COG0656	L-ascorbic acid biosynthetic process
HX109_RS02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HX109_RS02430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HX109_RS02430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HX109_RS02435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HX109_RS02500	COG4680	protein conserved in bacteria
HX109_RS02510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HX109_RS02525	COG0799	negative regulation of ribosome biogenesis
HX109_RS02530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HX109_RS02540	COG4589	Belongs to the CDS family
HX109_RS02545	COG0688	phosphatidylethanolamine metabolic process
HX109_RS02555	COG0640	Transcriptional regulator
HX109_RS02560	COG5658	integral membrane protein
HX109_RS02565	COG0525	valine-tRNA ligase activity
HX109_RS02575	COG0750	zinc metalloprotease
HX109_RS02580	COG0436	Aminotransferase
HX109_RS02585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HX109_RS02590	COG1595	DNA-templated transcription, initiation
HX109_RS02605	COG2274	protein secretion by the type I secretion system
HX109_RS02630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HX109_RS02635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HX109_RS02640	COG0534	Mate efflux family protein
HX109_RS02655	COG0018	arginyl-trna synthetase
HX109_RS02665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HX109_RS02710	COG0297	glycogen (starch) synthase activity
HX109_RS02715	COG0148	phosphopyruvate hydratase activity
HX109_RS02720	COG0505	Belongs to the CarA family
HX109_RS02725	COG0203	ribosomal protein L17
HX109_RS02730	COG0202	RNA polymerase activity
HX109_RS02735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HX109_RS02740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HX109_RS02745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HX109_RS02750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HX109_RS02755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HX109_RS02760	COG0201	protein transport
HX109_RS02765	COG0200	Binds to the 23S rRNA
HX109_RS02770	COG1841	ribosomal large subunit assembly
HX109_RS02775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HX109_RS02780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HX109_RS02785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HX109_RS02790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HX109_RS02795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HX109_RS02800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HX109_RS02805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HX109_RS02810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HX109_RS02815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HX109_RS02820	COG0255	Belongs to the universal ribosomal protein uL29 family
HX109_RS02825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HX109_RS02830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HX109_RS02835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HX109_RS02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HX109_RS02845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HX109_RS02850	COG0089	rRNA binding
HX109_RS02855	COG0088	Forms part of the polypeptide exit tunnel
HX109_RS02860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HX109_RS02865	COG0051	transcription antitermination factor activity, RNA binding
HX109_RS02870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HX109_RS02875	COG0049	tRNA binding
HX109_RS02880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HX109_RS02885	COG4206	TonB-dependent receptor
HX109_RS02885	COG1629	transport
HX109_RS02905	COG1629	transport
HX109_RS02915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HX109_RS02925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HX109_RS02955	COG2003	Belongs to the UPF0758 family
HX109_RS02975	COG2885	chlorophyll binding
HX109_RS02980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HX109_RS02995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HX109_RS03000	COG0563	adenylate kinase activity
HX109_RS03010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HX109_RS03015	COG3119	arylsulfatase activity
HX109_RS03040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HX109_RS03075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HX109_RS03090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HX109_RS03095	COG0791	NLP P60 protein
HX109_RS03095	COG1388	LysM domain
HX109_RS03100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HX109_RS03115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HX109_RS03120	COG1278	Cold shock
HX109_RS03125	COG0753	catalase activity
HX109_RS03140	COG2217	Heavy metal translocating P-type atpase
HX109_RS03160	COG2010	Cytochrome c
HX109_RS03165	COG0348	domain, Protein
HX109_RS03180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HX109_RS03185	COG1629	transport
HX109_RS03205	COG0616	signal peptide processing
HX109_RS03210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HX109_RS03240	COG0673	inositol 2-dehydrogenase activity
HX109_RS03275	COG0488	(ABC) transporter
HX109_RS03285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HX109_RS03285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HX109_RS03305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HX109_RS03330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HX109_RS03355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HX109_RS03360	COG0459	protein refolding
HX109_RS03365	COG3119	arylsulfatase activity
HX109_RS03370	COG1741	Belongs to the pirin family
HX109_RS03380	COG1956	GAF domain-containing protein
HX109_RS03385	COG0138	bifunctional purine biosynthesis protein purh
HX109_RS03390	COG1077	Cell shape determining protein MreB Mrl
HX109_RS03400	COG0768	penicillin binding
HX109_RS03405	COG0772	Belongs to the SEDS family
HX109_RS03420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HX109_RS03430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS03435	COG0791	NLP P60 protein
HX109_RS03440	COG2333	competence protein COMEC
HX109_RS03440	COG0658	competence protein
HX109_RS03445	COG3104	oligopeptide transport
HX109_RS03450	COG0823	Involved in the tonB-independent uptake of proteins
HX109_RS03450	COG1506	peptidase
HX109_RS03455	COG1752	Esterase of the alpha-beta hydrolase superfamily
HX109_RS03485	COG4535	Mg2 and Co2 transporter CorC
HX109_RS03510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HX109_RS03555	COG0745	RESPONSE REGULATOR receiver
HX109_RS03565	COG4999	Histidine kinase
HX109_RS03565	COG3850	Histidine kinase
HX109_RS03565	COG3437	response regulator, receiver
HX109_RS03565	COG2205	protein histidine kinase activity
HX109_RS03570	COG0750	zinc metalloprotease
HX109_RS03580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HX109_RS03585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HX109_RS03595	COG0484	heat shock protein binding
HX109_RS03625	COG0489	protein tyrosine kinase activity
HX109_RS03635	COG0492	ferredoxin-NADP+ reductase activity
HX109_RS03640	COG0633	Ferredoxin
HX109_RS03655	COG4993	Dehydrogenase
HX109_RS03695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HX109_RS03720	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS03730	COG1522	sequence-specific DNA binding
HX109_RS03740	COG2957	Belongs to the agmatine deiminase family
HX109_RS03750	COG1757	Na H antiporter
HX109_RS03800	COG2177	Part of the ABC transporter FtsEX involved in
HX109_RS03810	COG1968	undecaprenyl-diphosphatase activity
HX109_RS03815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HX109_RS03830	COG0519	Catalyzes the synthesis of GMP from XMP
HX109_RS03835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HX109_RS03845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HX109_RS03850	COG5000	phosphorelay sensor kinase activity
HX109_RS03865	COG3118	belongs to the thioredoxin family
HX109_RS03875	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HX109_RS03890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HX109_RS03890	COG1519	Transferase
HX109_RS03900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HX109_RS03905	COG0402	S-adenosylhomocysteine deaminase activity
HX109_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS03925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HX109_RS03940	COG0792	nuclease activity
HX109_RS03955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HX109_RS03955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HX109_RS03960	COG0123	including yeast histone deacetylase and acetoin utilization protein
HX109_RS03975	COG1528	Iron-storage protein
HX109_RS03980	COG0629	single-stranded DNA binding
HX109_RS03985	COG3153	acetyltransferase
HX109_RS03985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HX109_RS04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HX109_RS04015	COG3590	peptidase
HX109_RS04025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HX109_RS04030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HX109_RS04035	COG0303	'Molybdopterin
HX109_RS04045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HX109_RS04060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HX109_RS04070	COG2814	Major facilitator Superfamily
HX109_RS04075	COG1621	beta-fructofuranosidase activity
HX109_RS04100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HX109_RS04105	COG2226	methyltransferase
HX109_RS04115	COG0740	serine-type endopeptidase activity
HX109_RS04120	COG3119	arylsulfatase activity
HX109_RS04130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HX109_RS04150	COG1215	transferase activity, transferring glycosyl groups
HX109_RS04160	COG1187	pseudouridine synthase activity
HX109_RS04225	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HX109_RS04230	COG2081	HI0933 family
HX109_RS04260	COG0366	Alpha amylase catalytic
HX109_RS04265	COG1082	Xylose isomerase domain protein TIM barrel
HX109_RS04270	COG1554	hydrolase, family 65, central catalytic
HX109_RS04275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HX109_RS04295	COG1609	Transcriptional regulator
HX109_RS04300	COG4206	TonB-dependent receptor
HX109_RS04300	COG1629	transport
HX109_RS04305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HX109_RS04320	COG1629	transport
HX109_RS04380	COG4771	TonB-dependent receptor
HX109_RS04385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HX109_RS04395	COG0297	glycogen (starch) synthase activity
HX109_RS04400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HX109_RS04405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HX109_RS04420	COG2318	DinB family
HX109_RS04440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HX109_RS04450	COG0739	heme binding
HX109_RS04455	COG0667	Aldo Keto reductase
HX109_RS04460	COG1360	Flagellar Motor Protein
HX109_RS04465	COG0708	Exodeoxyribonuclease III
HX109_RS04470	COG4206	TonB-dependent receptor
HX109_RS04485	COG3118	belongs to the thioredoxin family
HX109_RS04490	COG1408	metallophosphoesterase
HX109_RS04495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HX109_RS04495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HX109_RS04500	COG4771	TonB-dependent receptor
HX109_RS04520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HX109_RS04525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HX109_RS04530	COG0052	Belongs to the universal ribosomal protein uS2 family
HX109_RS04535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HX109_RS04540	COG0528	UMP kinase activity
HX109_RS04545	COG0233	cytoplasmic translational termination
HX109_RS04560	COG0017	Asparaginyl-tRNA synthetase
HX109_RS04595	COG0811	peptide transport
HX109_RS04605	COG0252	asparaginase activity
HX109_RS04615	COG0084	hydrolase, TatD family'
HX109_RS04625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HX109_RS04630	COG0567	Dehydrogenase, E1 component
HX109_RS04655	COG2211	Major facilitator Superfamily
HX109_RS04660	COG0673	inositol 2-dehydrogenase activity
HX109_RS04665	COG0673	inositol 2-dehydrogenase activity
HX109_RS04685	COG3119	arylsulfatase activity
HX109_RS04690	COG0469	pyruvate kinase activity
HX109_RS04700	COG0571	ribonuclease III activity
HX109_RS04705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HX109_RS04710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HX109_RS04715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HX109_RS04720	COG0328	RNA-DNA hybrid ribonuclease activity
HX109_RS04750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HX109_RS04765	COG1309	transcriptional regulator
HX109_RS04815	COG1999	signal sequence binding
HX109_RS04850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HX109_RS04990	COG1404	Belongs to the peptidase S8 family
HX109_RS05000	COG4771	TonB-dependent receptor
HX109_RS05015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HX109_RS05020	COG0702	epimerase
HX109_RS05025	COG4771	TonB-dependent receptor
HX109_RS05035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HX109_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS05045	COG4677	pectinesterase activity
HX109_RS05050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HX109_RS05065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HX109_RS05075	COG0156	8-amino-7-oxononanoate synthase activity
HX109_RS05080	COG2885	chlorophyll binding
HX109_RS05105	COG1752	Esterase of the alpha-beta hydrolase superfamily
HX109_RS05120	COG2153	protein acetylation
HX109_RS05145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HX109_RS05155	COG2022	thiamine diphosphate biosynthetic process
HX109_RS05160	COG0352	thiamine-phosphate diphosphorylase activity
HX109_RS05165	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HX109_RS05165	COG0352	thiamine-phosphate diphosphorylase activity
HX109_RS05165	COG0351	phosphomethylpyrimidine kinase
HX109_RS05175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HX109_RS05185	COG2839	Protein conserved in bacteria
HX109_RS05195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HX109_RS05200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HX109_RS05205	COG0511	ligase activity, forming carbon-carbon bonds
HX109_RS05210	COG0439	Biotin carboxylase
HX109_RS05215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HX109_RS05235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HX109_RS05240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HX109_RS05245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HX109_RS05250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HX109_RS05255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HX109_RS05260	COG0356	it plays a direct role in the translocation of protons across the membrane
HX109_RS05290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HX109_RS05300	COG4124	Belongs to the glycosyl hydrolase 26 family
HX109_RS05305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HX109_RS05315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HX109_RS05330	COG3938	Belongs to the proline racemase family
HX109_RS05335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HX109_RS05345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HX109_RS05350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HX109_RS05370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HX109_RS05430	COG1201	RNA secondary structure unwinding
HX109_RS05435	COG1793	dna ligase
HX109_RS05440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HX109_RS05440	COG1793	dna ligase
HX109_RS05445	COG0228	four-way junction DNA binding
HX109_RS05450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HX109_RS05455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HX109_RS05475	COG1960	acyl-CoA dehydrogenase activity
HX109_RS05525	COG0791	NLP P60 protein
HX109_RS05530	COG0481	GTPase activity
HX109_RS05555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HX109_RS05570	COG0594	ribonuclease P activity
HX109_RS05575	COG0793	Belongs to the peptidase S41A family
HX109_RS05600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HX109_RS05605	COG0463	Glycosyl transferase, family 2
HX109_RS05625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HX109_RS05645	COG0470	DNA polymerase III
HX109_RS05650	COG0126	phosphoglycerate kinase activity
HX109_RS05655	COG1705	Flagellar rod assembly protein muramidase FlgJ
HX109_RS05655	COG1388	LysM domain
HX109_RS05665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HX109_RS05670	COG4942	peptidase
HX109_RS05700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HX109_RS05715	COG0316	Belongs to the HesB IscA family
HX109_RS05720	COG0719	Fe-S assembly protein
HX109_RS05725	COG0396	ATPase activity
HX109_RS05735	COG0719	Fe-S assembly protein
HX109_RS05750	COG0564	pseudouridine synthase activity
HX109_RS05770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HX109_RS05785	COG0495	leucyl-tRNA aminoacylation
HX109_RS05790	COG0686	Belongs to the AlaDH PNT family
HX109_RS05795	COG2738	Putative neutral zinc metallopeptidase
HX109_RS05800	COG1522	sequence-specific DNA binding
HX109_RS05815	COG2363	Small membrane protein
HX109_RS05830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HX109_RS05855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HX109_RS05870	COG0698	ribose 5-phosphate isomerase
HX109_RS05880	COG0557	exoribonuclease II activity
HX109_RS05915	COG0445	tRNA wobble uridine modification
HX109_RS05920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HX109_RS05930	COG3239	Fatty acid desaturase
HX109_RS05985	COG2354	Protein conserved in bacteria
HX109_RS05990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HX109_RS06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HX109_RS06045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HX109_RS06050	COG0346	lactoylglutathione lyase activity
HX109_RS06055	COG2827	Endonuclease containing a URI domain
HX109_RS06090	COG3220	belongs to the UPF0276 family
HX109_RS06095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HX109_RS06125	COG0180	Tryptophanyl-tRNA synthetase
HX109_RS06130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HX109_RS06130	COG0758	DNA mediated transformation
HX109_RS06140	COG1607	acyl-coa hydrolase
HX109_RS06165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HX109_RS06175	COG0756	dUTP diphosphatase activity
HX109_RS06205	COG1505	serine-type exopeptidase activity
HX109_RS06210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HX109_RS06215	COG1970	mechanosensitive ion channel activity
HX109_RS06225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HX109_RS06230	COG1435	thymidine kinase activity
HX109_RS06250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HX109_RS06255	COG1573	uracil-dna glycosylase
HX109_RS06265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HX109_RS06265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HX109_RS06270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HX109_RS06275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HX109_RS06280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HX109_RS06300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HX109_RS06310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HX109_RS06315	COG2267	carboxylic ester hydrolase activity
HX109_RS06320	COG3002	Belongs to the UPF0753 family
HX109_RS06340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS06345	COG0720	synthase
HX109_RS06365	COG1774	PSP1 C-terminal conserved region
HX109_RS06380	COG1335	isochorismatase
HX109_RS06390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HX109_RS06395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HX109_RS06400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HX109_RS06415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HX109_RS06425	COG1053	succinate dehydrogenase
HX109_RS06440	COG0006	proline dipeptidase activity
HX109_RS06455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HX109_RS06460	COG2166	iron-sulfur cluster assembly
HX109_RS06465	COG2151	metal-sulfur cluster biosynthetic enzyme
HX109_RS06490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HX109_RS06520	COG1253	flavin adenine dinucleotide binding
HX109_RS06530	COG0113	porphobilinogen synthase activity
HX109_RS06540	COG0408	coproporphyrinogen oxidase activity
HX109_RS06555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HX109_RS06570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HX109_RS06580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HX109_RS06595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HX109_RS06600	COG0534	Mate efflux family protein
HX109_RS06620	COG3409	Peptidoglycan-binding domain 1 protein
HX109_RS06620	COG0793	Belongs to the peptidase S41A family
HX109_RS06665	COG1418	mRNA catabolic process
HX109_RS06685	COG4771	TonB-dependent receptor
HX109_RS06690	COG0702	epimerase
HX109_RS06710	COG1024	Enoyl-CoA hydratase
HX109_RS06715	COG5000	phosphorelay sensor kinase activity
HX109_RS06730	COG2095	MarC family integral membrane protein
HX109_RS06750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HX109_RS06750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HX109_RS06770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HX109_RS06785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HX109_RS06795	COG0590	tRNA wobble adenosine to inosine editing
HX109_RS06805	COG1278	Cold shock
HX109_RS06830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HX109_RS06840	COG1561	YicC-like family, N-terminal region
HX109_RS06845	COG0194	GDP metabolic process
HX109_RS06855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HX109_RS06860	COG1652	LysM domain
HX109_RS06865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HX109_RS06890	COG4585	Histidine kinase
HX109_RS06925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HX109_RS06930	COG4953	penicillin-binding protein 1C
HX109_RS06935	COG2373	Large extracellular alpha-helical protein
HX109_RS06940	COG1446	asparaginase
HX109_RS06965	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS06985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HX109_RS06990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HX109_RS07000	COG4221	oxidoreductase activity
HX109_RS07005	COG4989	oxidoreductase activity
HX109_RS07015	COG0714	Associated with various cellular activities
HX109_RS07030	COG2304	oxidoreductase activity
HX109_RS07035	COG2304	oxidoreductase activity
HX109_RS07065	COG0288	reversible hydration of carbon dioxide
HX109_RS07075	COG0702	epimerase
HX109_RS07080	COG1286	toxin biosynthetic process
HX109_RS07090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HX109_RS07100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HX109_RS07115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HX109_RS07125	COG1538	Outer membrane efflux protein
HX109_RS07130	COG0670	Belongs to the BI1 family
HX109_RS07145	COG0429	hydrolase of the alpha beta-hydrolase fold
HX109_RS07175	COG0626	cystathionine gamma-synthase activity
HX109_RS07180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HX109_RS07190	COG1381	Involved in DNA repair and RecF pathway recombination
HX109_RS07195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HX109_RS07210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HX109_RS07215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HX109_RS07230	COG0322	excinuclease ABC activity
HX109_RS07240	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HX109_RS07245	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HX109_RS07265	COG0166	Belongs to the GPI family
HX109_RS07270	COG4771	TonB-dependent receptor
HX109_RS07325	COG0423	glycine-tRNA ligase activity
HX109_RS07335	COG0784	Response regulator, receiver
HX109_RS07335	COG5002	protein histidine kinase activity
HX109_RS07375	COG0779	Required for maturation of 30S ribosomal subunits
HX109_RS07380	COG0195	Participates in both transcription termination and antitermination
HX109_RS07380	COG2251	uridine kinase activity
HX109_RS07385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HX109_RS07400	COG0437	4 iron, 4 sulfur cluster binding
HX109_RS07405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HX109_RS07405	COG3743	rRNA binding
HX109_RS07425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HX109_RS07430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HX109_RS07440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HX109_RS07455	COG3201	nicotinamide mononucleotide transporter
HX109_RS07475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HX109_RS07485	COG0531	amino acid
HX109_RS07500	COG2954	triphosphatase activity
HX109_RS07510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HX109_RS07515	COG1199	ATP-dependent helicase activity
HX109_RS07515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HX109_RS07525	COG2610	gluconate transmembrane transporter activity
HX109_RS07530	COG3119	arylsulfatase activity
HX109_RS07550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HX109_RS07560	COG1064	alcohol dehydrogenase
HX109_RS07565	COG1530	ribonuclease E activity
HX109_RS07580	COG0629	single-stranded DNA binding
HX109_RS07620	COG4771	TonB-dependent receptor
HX109_RS07640	COG0612	Peptidase, M16
HX109_RS07645	COG0612	Peptidase, M16
HX109_RS07655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HX109_RS07660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HX109_RS07675	COG0702	epimerase
HX109_RS07680	COG2255	four-way junction helicase activity
HX109_RS07690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HX109_RS07705	COG0281	malic enzyme
HX109_RS07705	COG0280	phosphate acetyltransferase
HX109_RS07710	COG0632	four-way junction helicase activity
HX109_RS07720	COG0509	glycine decarboxylation via glycine cleavage system
HX109_RS07740	COG0109	protoheme IX farnesyltransferase activity
HX109_RS07750	COG1845	cytochrome c oxidase, subunit III
HX109_RS07765	COG1999	signal sequence binding
HX109_RS07770	COG2322	membrane
HX109_RS07780	COG1136	(ABC) transporter
HX109_RS07780	COG0577	efflux transmembrane transporter activity
HX109_RS07785	COG1136	(ABC) transporter
HX109_RS07785	COG0577	efflux transmembrane transporter activity
HX109_RS07790	COG0577	efflux transmembrane transporter activity
HX109_RS07795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HX109_RS07805	COG1214	PFAM Peptidase M22, glycoprotease
HX109_RS07810	COG0668	transmembrane transport
HX109_RS07830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HX109_RS07840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HX109_RS07845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HX109_RS07860	COG3119	arylsulfatase activity
HX109_RS07865	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HX109_RS07870	COG1518	maintenance of DNA repeat elements
HX109_RS07950	COG4974	Belongs to the 'phage' integrase family
HX109_RS07965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HX109_RS07970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HX109_RS07975	COG0193	aminoacyl-tRNA hydrolase activity
HX109_RS07990	COG0196	riboflavin kinase activity
HX109_RS08010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HX109_RS08025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HX109_RS08030	COG2239	Acts as a magnesium transporter
HX109_RS08040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HX109_RS08065	COG0527	aspartate kinase activity
HX109_RS08075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HX109_RS08095	COG1428	Deoxynucleoside kinase
HX109_RS08105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HX109_RS08135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HX109_RS08160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HX109_RS08165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HX109_RS08170	COG5002	protein histidine kinase activity
HX109_RS08175	COG0745	RESPONSE REGULATOR receiver
HX109_RS08205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HX109_RS08215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HX109_RS08225	COG1482	cell wall glycoprotein biosynthetic process
HX109_RS08285	COG0070	glutamate synthase
HX109_RS08285	COG0069	glutamate synthase activity
HX109_RS08285	COG0067	glutamate synthase
HX109_RS08290	COG1960	acyl-CoA dehydrogenase activity
HX109_RS08295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HX109_RS08300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HX109_RS08305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HX109_RS08310	COG0811	peptide transport
HX109_RS08315	COG0848	biopolymer transport protein
HX109_RS08325	COG0285	dihydrofolate synthase activity
HX109_RS08340	COG1272	protein, Hemolysin III
HX109_RS08355	COG0673	inositol 2-dehydrogenase activity
HX109_RS08365	COG0116	Belongs to the methyltransferase superfamily
HX109_RS08385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HX109_RS08420	COG0714	Associated with various cellular activities
HX109_RS08450	COG2860	membrane
HX109_RS08455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HX109_RS08485	COG1252	NADH dehydrogenase
HX109_RS08490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HX109_RS08500	COG0544	peptidyl-prolyl cis-trans isomerase activity
HX109_RS08505	COG1950	PFAM Membrane protein of
HX109_RS08525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HX109_RS08535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HX109_RS08545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HX109_RS08565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HX109_RS08570	COG1629	transport
HX109_RS08580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HX109_RS08690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HX109_RS08695	COG0515	serine threonine protein kinase
HX109_RS08695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HX109_RS08710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HX109_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS08750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HX109_RS08765	COG0659	secondary active sulfate transmembrane transporter activity
HX109_RS08770	COG2197	response regulator
HX109_RS08780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HX109_RS08785	COG1181	Belongs to the D-alanine--D-alanine ligase family
HX109_RS08790	COG0515	serine threonine protein kinase
HX109_RS08790	COG2815	serine threonine protein kinase
HX109_RS08795	COG0564	pseudouridine synthase activity
HX109_RS08800	COG3022	response to hydroperoxide
HX109_RS08820	COG0159	tryptophan synthase activity
HX109_RS08825	COG0133	tryptophan synthase activity
HX109_RS08830	COG0135	phosphoribosylanthranilate isomerase activity
HX109_RS08835	COG0134	indole-3-glycerol-phosphate synthase activity
HX109_RS08845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HX109_RS08855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HX109_RS08855	COG0512	Glutamine amidotransferase of anthranilate synthase
HX109_RS08860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HX109_RS08865	COG2353	YceI-like domain
HX109_RS08870	COG0778	Nitroreductase
HX109_RS08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HX109_RS08910	COG1115	amino acid carrier protein
HX109_RS08920	COG1960	acyl-CoA dehydrogenase activity
HX109_RS08925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HX109_RS08930	COG4974	Belongs to the 'phage' integrase family
HX109_RS08935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HX109_RS08980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HX109_RS08985	COG0081	regulation of translation
HX109_RS08990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HX109_RS08995	COG0222	ribosome binding
HX109_RS09000	COG0085	RNA polymerase activity
HX109_RS09005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HX109_RS09025	COG0101	tRNA pseudouridine synthase activity
HX109_RS09030	COG1132	(ABC) transporter
HX109_RS09045	COG1741	Belongs to the pirin family
HX109_RS09080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HX109_RS09105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HX109_RS09110	COG1663	tetraacyldisaccharide 4'-kinase activity
HX109_RS09120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HX109_RS09125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HX109_RS09150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HX109_RS09155	COG3119	arylsulfatase activity
HX109_RS09160	COG1368	sulfuric ester hydrolase activity
HX109_RS09165	COG3119	arylsulfatase activity
HX109_RS09180	COG1757	Na H antiporter
HX109_RS09185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HX109_RS09190	COG1160	GTP binding
HX109_RS09200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HX109_RS09210	COG1704	LemA family
HX109_RS09220	COG0739	heme binding
HX109_RS09225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HX109_RS09245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HX109_RS09250	COG0401	homolog of Blt101
HX109_RS09260	COG0321	lipoyl(octanoyl) transferase activity
HX109_RS09270	COG4206	TonB-dependent receptor
HX109_RS09270	COG1629	transport
HX109_RS09275	COG0702	epimerase
HX109_RS09285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HX109_RS09310	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HX109_RS09315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HX109_RS09320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HX109_RS09330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HX109_RS09340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HX109_RS09345	COG2086	electron transfer activity
HX109_RS09350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HX109_RS09350	COG0022	dehydrogenase e1 component
HX109_RS09360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HX109_RS09365	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HX109_RS09370	COG2161	toxin-antitoxin pair type II binding
HX109_RS09375	COG4115	mRNA cleavage
HX109_RS09380	COG1428	Deoxynucleoside kinase
HX109_RS09385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HX109_RS09395	COG0460	homoserine dehydrogenase
HX109_RS09395	COG0527	aspartate kinase activity
HX109_RS09410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HX109_RS09415	COG1648	precorrin-2 dehydrogenase activity
HX109_RS09415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HX109_RS09420	COG1648	precorrin-2 dehydrogenase activity
HX109_RS09420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HX109_RS09425	COG0492	ferredoxin-NADP+ reductase activity
HX109_RS09445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HX109_RS09460	COG1252	NADH dehydrogenase
HX109_RS09480	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HX109_RS09485	COG1605	Chorismate mutase
HX109_RS09485	COG0077	Prephenate dehydratase
HX109_RS09490	COG0436	Aminotransferase
HX109_RS09500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HX109_RS09505	COG1162	GTPase activity
HX109_RS09510	COG1490	D-aminoacyl-tRNA deacylase activity
HX109_RS09530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HX109_RS09545	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HX109_RS09550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HX109_RS09560	COG1595	DNA-templated transcription, initiation
HX109_RS09575	COG0358	DNA primase activity
HX109_RS09585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HX109_RS09605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HX109_RS09610	COG2267	carboxylic ester hydrolase activity
HX109_RS09615	COG2001	Belongs to the MraZ family
HX109_RS09620	COG0275	rRNA processing
HX109_RS09630	COG0768	penicillin binding
HX109_RS09635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HX109_RS09640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HX109_RS09645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HX109_RS09650	COG0772	Belongs to the SEDS family
HX109_RS09655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HX109_RS09660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HX109_RS09675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HX109_RS09680	COG1610	YqeY-like protein
HX109_RS09695	COG2207	Transcriptional regulator
HX109_RS09710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HX109_RS09730	COG2188	Transcriptional regulator
HX109_RS09735	COG1082	Xylose isomerase domain protein TIM barrel
HX109_RS09760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HX109_RS09770	COG0561	phosphatase activity
HX109_RS09775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HX109_RS09795	COG2169	Transcriptional regulator
HX109_RS09795	COG1917	Cupin 2, conserved barrel domain protein
HX109_RS09845	COG0561	phosphatase activity
HX109_RS09850	COG0432	Pfam Uncharacterised protein family UPF0047
HX109_RS09855	COG3291	Pkd domain containing protein
HX109_RS09895	COG1185	polyribonucleotide nucleotidyltransferase activity
HX109_RS09900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HX109_RS09910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HX109_RS09915	COG0191	fructose-bisphosphate aldolase activity
HX109_RS09935	COG2226	methyltransferase
HX109_RS09940	COG0569	domain protein
HX109_RS09945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HX109_RS09950	COG0436	Aminotransferase
HX109_RS09955	COG3239	Fatty acid desaturase
HX109_RS09960	COG0357	Ribosomal RNA small subunit methyltransferase G
HX109_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS09990	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HX109_RS09995	COG1805	sodium ion transport
HX109_RS10005	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HX109_RS10010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HX109_RS10025	COG1477	protein flavinylation
HX109_RS10030	COG2226	methyltransferase
HX109_RS10055	COG3340	Belongs to the peptidase S51 family
HX109_RS10070	COG2388	GCN5-related N-acetyl-transferase
HX109_RS10075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HX109_RS10090	COG4771	TonB-dependent receptor
HX109_RS10100	COG1446	asparaginase
HX109_RS10105	COG4242	Belongs to the peptidase S51 family
HX109_RS10110	COG1288	antiporter activity
HX109_RS10125	COG2207	Transcriptional regulator
HX109_RS10140	COG2115	Belongs to the xylose isomerase family
HX109_RS10150	COG0363	glucosamine-6-phosphate deaminase activity
HX109_RS10155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HX109_RS10160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HX109_RS10165	COG0698	ribose 5-phosphate isomerase
HX109_RS10175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HX109_RS10185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HX109_RS10190	COG2884	Cell division ATP-binding protein ftsE
HX109_RS10195	COG4771	TonB-dependent receptor
HX109_RS10215	COG1289	transmembrane transporter activity
HX109_RS10220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HX109_RS10225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HX109_RS10245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HX109_RS10250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HX109_RS10270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HX109_RS10305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HX109_RS10340	COG0433	COG0433 Predicted ATPase
HX109_RS10345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HX109_RS10355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HX109_RS10360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HX109_RS10380	COG3876	Protein conserved in bacteria
HX109_RS10395	COG2813	Specifically methylates the guanine in position
HX109_RS10405	COG0482	sulfurtransferase activity
HX109_RS10410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HX109_RS10420	COG1773	rubredoxin
HX109_RS10425	COG0243	molybdopterin cofactor binding
HX109_RS10430	COG2223	nitrite transmembrane transporter activity
HX109_RS10435	COG2197	response regulator
HX109_RS10440	COG4585	Histidine kinase
HX109_RS10455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HX109_RS10470	COG0702	epimerase
HX109_RS10475	COG4771	TonB-dependent receptor
HX109_RS10500	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HX109_RS10510	COG3534	alpha-L-arabinofuranosidase
HX109_RS10540	COG0673	inositol 2-dehydrogenase activity
HX109_RS10550	COG0183	Belongs to the thiolase family
HX109_RS10555	COG1480	7TM receptor with intracellular HD hydrolase
HX109_RS10580	COG0629	single-stranded DNA binding
HX109_RS10585	COG2003	Belongs to the UPF0758 family
HX109_RS10605	COG2319	Wd-40 repeat
HX109_RS10655	COG1629	transport
HX109_RS10660	COG0702	epimerase
HX109_RS10845	COG4974	Belongs to the 'phage' integrase family
HX109_RS10865	COG3620	sequence-specific DNA binding
HX109_RS10880	COG4968	Prepilin-type N-terminal cleavage methylation domain
HX109_RS10990	COG1459	type II secretion system
HX109_RS11050	COG1063	alcohol dehydrogenase
HX109_RS11055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HX109_RS11065	COG1349	DNA-binding transcription factor activity
HX109_RS11070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HX109_RS11085	COG0602	queuosine metabolic process
HX109_RS11110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HX109_RS11110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HX109_RS11130	COG1595	DNA-templated transcription, initiation
HX109_RS11135	COG0215	cysteine-tRNA ligase activity
HX109_RS11140	COG0302	gtp cyclohydrolase
HX109_RS11155	COG3781	membrane
HX109_RS11160	COG2226	methyltransferase
HX109_RS11175	COG0442	prolyl-tRNA aminoacylation
HX109_RS11190	COG0268	Binds directly to 16S ribosomal RNA
HX109_RS11195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HX109_RS11205	COG0450	alkyl hydroperoxide reductase
HX109_RS11220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HX109_RS11230	COG1132	(ABC) transporter
HX109_RS11240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HX109_RS11250	COG1862	Preprotein translocase
HX109_RS11260	COG2195	Cleaves the N-terminal amino acid of tripeptides
HX109_RS11265	COG0167	dihydroorotate dehydrogenase activity
HX109_RS11275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HX109_RS11305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HX109_RS11310	COG0516	GMP reductase activity
HX109_RS11310	COG0517	IMP dehydrogenase activity
HX109_RS11335	COG4771	TonB-dependent receptor
HX109_RS11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HX109_RS11370	COG1475	DNA binding
HX109_RS11375	COG1192	Involved in chromosome partitioning
HX109_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS11385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS11385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS11390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS11390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HX109_RS11400	COG0572	uridine kinase
HX109_RS11435	COG1131	(ABC) transporter
HX109_RS11455	COG0004	ammonium transporteR
HX109_RS11460	COG0347	Belongs to the P(II) protein family
HX109_RS11465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HX109_RS11485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HX109_RS11495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HX109_RS11495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HX109_RS11510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HX109_RS11515	COG0484	heat shock protein binding
HX109_RS11520	COG4152	abc transporter atp-binding protein
HX109_RS11525	COG1668	transmembrane transport
HX109_RS11530	COG3264	Mechanosensitive ion channel
HX109_RS11530	COG1196	nuclear chromosome segregation
HX109_RS11545	COG1132	(ABC) transporter
HX109_RS11550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HX109_RS11555	COG0463	Glycosyl transferase, family 2
HX109_RS11565	COG0254	rRNA binding
HX109_RS11575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HX109_RS11595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HX109_RS11600	COG0497	DNA recombination
HX109_RS11615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HX109_RS11645	COG1629	transport
HX109_RS11660	COG4948	Mandelate Racemase Muconate Lactonizing
HX109_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS11710	COG3119	arylsulfatase activity
HX109_RS11725	COG0702	epimerase
HX109_RS11730	COG4771	TonB-dependent receptor
HX109_RS11735	COG3119	arylsulfatase activity
HX109_RS11750	COG3119	arylsulfatase activity
HX109_RS11760	COG3119	arylsulfatase activity
HX109_RS11770	COG4771	TonB-dependent receptor
HX109_RS11775	COG0702	epimerase
HX109_RS11780	COG1917	Cupin 2, conserved barrel domain protein
HX109_RS11780	COG4977	sequence-specific DNA binding
HX109_RS11795	COG3537	Alpha-1,2-mannosidase
HX109_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS11805	COG4948	Mandelate Racemase Muconate Lactonizing
HX109_RS11820	COG1940	carbohydrate kinase activity
HX109_RS11825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HX109_RS11885	COG1678	Uncharacterized ACR, COG1678
HX109_RS11895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HX109_RS11900	COG0514	ATP-dependent DNA helicase (RecQ)
HX109_RS11920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HX109_RS11925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HX109_RS11930	COG0540	Belongs to the ATCase OTCase family
HX109_RS11940	COG1234	tRNA 3'-trailer cleavage
HX109_RS11945	COG0259	pyridoxamine-phosphate oxidase activity
HX109_RS11950	COG2340	Cysteine-rich secretory protein family
HX109_RS11975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HX109_RS11995	COG1607	acyl-coa hydrolase
HX109_RS12000	COG1322	Protein conserved in bacteria
HX109_RS12010	COG1629	transport
HX109_RS12015	COG0702	epimerase
HX109_RS12035	COG1472	Belongs to the glycosyl hydrolase 3 family
HX109_RS12045	COG3119	arylsulfatase activity
HX109_RS12055	COG1120	ATPase activity
HX109_RS12065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HX109_RS12075	COG4206	TonB-dependent receptor
HX109_RS12085	COG1595	DNA-templated transcription, initiation
HX109_RS12110	COG0105	UTP biosynthetic process
HX109_RS12125	COG2356	endonuclease I
HX109_RS12130	COG0363	glucosamine-6-phosphate deaminase activity
HX109_RS12135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HX109_RS12155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HX109_RS12165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HX109_RS12185	COG2133	pyrroloquinoline quinone binding
HX109_RS12190	COG2814	Major facilitator Superfamily
HX109_RS12200	COG1119	ATPase activity
HX109_RS12235	COG1418	mRNA catabolic process
HX109_RS12245	COG2706	6-phosphogluconolactonase activity
HX109_RS12250	COG3237	CsbD-like
HX109_RS12260	COG0175	sulfate reduction
HX109_RS12275	COG0071	Belongs to the small heat shock protein (HSP20) family
HX109_RS12290	COG1131	(ABC) transporter
HX109_RS12305	COG0657	acetylesterase activity
HX109_RS12305	COG2755	lipolytic protein G-D-S-L family
HX109_RS12310	COG0657	acetylesterase activity
HX109_RS12310	COG2755	lipolytic protein G-D-S-L family
HX109_RS12335	COG2205	protein histidine kinase activity
HX109_RS12340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HX109_RS12350	COG0363	glucosamine-6-phosphate deaminase activity
HX109_RS12360	COG1629	transport
HX109_RS12365	COG3275	phosphorelay sensor kinase activity
HX109_RS12370	COG3279	Response regulator of the LytR AlgR family
HX109_RS12380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HX109_RS12380	COG0519	Catalyzes the synthesis of GMP from XMP
HX109_RS12385	COG1388	LysM domain
HX109_RS12385	COG3942	CHAP domain
HX109_RS12415	COG0415	Belongs to the DNA photolyase family
HX109_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS12430	COG0129	dihydroxy-acid dehydratase activity
HX109_RS12435	COG0028	Belongs to the TPP enzyme family
HX109_RS12440	COG0440	acetolactate synthase activity
HX109_RS12445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HX109_RS12450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HX109_RS12470	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HX109_RS12475	COG2234	aminopeptidase activity
HX109_RS12520	COG0564	pseudouridine synthase activity
HX109_RS12525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HX109_RS12545	COG0529	Catalyzes the synthesis of activated sulfate
HX109_RS12550	COG0175	sulfate reduction
HX109_RS12555	COG2827	Endonuclease containing a URI domain
HX109_RS12605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HX109_RS12610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HX109_RS12650	COG0673	inositol 2-dehydrogenase activity
HX109_RS12655	COG5434	Belongs to the glycosyl hydrolase 28 family
HX109_RS12690	COG3549	Plasmid maintenance system killer
HX109_RS12760	COG3549	Plasmid maintenance system killer
HX109_RS12765	COG4974	Belongs to the 'phage' integrase family
HX109_RS12770	COG0473	3-isopropylmalate dehydrogenase activity
HX109_RS12775	COG0066	3-isopropylmalate dehydratase activity
HX109_RS12780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HX109_RS12785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HX109_RS12810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HX109_RS12820	COG0737	Belongs to the 5'-nucleotidase family
HX109_RS12825	COG0737	Belongs to the 5'-nucleotidase family
HX109_RS12835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HX109_RS12855	COG1247	-acetyltransferase
HX109_RS12860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HX109_RS12870	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HX109_RS12940	COG3119	arylsulfatase activity
HX109_RS12955	COG2169	Transcriptional regulator
HX109_RS12955	COG1917	Cupin 2, conserved barrel domain protein
HX109_RS12990	COG1902	pentaerythritol trinitrate reductase activity
HX109_RS13015	COG1368	sulfuric ester hydrolase activity
HX109_RS13045	COG0673	inositol 2-dehydrogenase activity
HX109_RS13050	COG1960	acyl-CoA dehydrogenase activity
HX109_RS13080	COG4771	TonB-dependent receptor
HX109_RS13110	COG1024	Enoyl-CoA hydratase
HX109_RS13115	COG4670	ketone body catabolic process
HX109_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS13125	COG3537	Alpha-1,2-mannosidase
HX109_RS13130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HX109_RS13135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HX109_RS13140	COG3537	Alpha-1,2-mannosidase
HX109_RS13155	COG1082	Xylose isomerase domain protein TIM barrel
HX109_RS13180	COG2814	Major facilitator Superfamily
HX109_RS13185	COG3119	arylsulfatase activity
HX109_RS13190	COG2133	pyrroloquinoline quinone binding
HX109_RS13220	COG1733	regulation of RNA biosynthetic process
HX109_RS13225	COG2801	Transposase and inactivated derivatives
HX109_RS13230	COG2801	Transposase and inactivated derivatives
HX109_RS13235	COG2963	transposase activity
HX109_RS13255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HX109_RS13260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HX109_RS13260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HX109_RS13275	COG1674	ftsk spoiiie
HX109_RS13285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HX109_RS13300	COG0450	alkyl hydroperoxide reductase
HX109_RS13320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HX109_RS13330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HX109_RS13345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HX109_RS13365	COG1858	cytochrome C peroxidase
HX109_RS13375	COG1136	(ABC) transporter
HX109_RS13390	COG1045	serine acetyltransferase
HX109_RS13395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HX109_RS13435	COG3265	gluconokinase activity
HX109_RS13445	COG0443	Heat shock 70 kDa protein
HX109_RS13450	COG0514	ATP-dependent DNA helicase (RecQ)
HX109_RS13470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HX109_RS13480	COG2996	Protein conserved in bacteria
HX109_RS13495	COG1575	Belongs to the MenA family. Type 1 subfamily
HX109_RS13500	COG0784	Response regulator, receiver
HX109_RS13505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HX109_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS13530	COG0156	8-amino-7-oxononanoate synthase activity
HX109_RS13595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HX109_RS13600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HX109_RS13635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HX109_RS13635	COG0321	lipoyl(octanoyl) transferase activity
HX109_RS13650	COG0037	tRNA processing
HX109_RS13675	COG1285	pathogenesis
HX109_RS13695	COG1522	sequence-specific DNA binding
HX109_RS13700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HX109_RS13725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HX109_RS13735	COG0488	(ABC) transporter
HX109_RS13740	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HX109_RS13750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HX109_RS13760	COG1295	ribonuclease BN
HX109_RS13770	COG2378	regulation of single-species biofilm formation
HX109_RS13785	COG2814	Major facilitator Superfamily
HX109_RS13790	COG0386	Belongs to the glutathione peroxidase family
HX109_RS13795	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HX109_RS13810	COG0303	'Molybdopterin
HX109_RS13815	COG0314	molybdopterin synthase activity
HX109_RS13820	COG0521	Mo-molybdopterin cofactor biosynthetic process
HX109_RS13830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HX109_RS13860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HX109_RS13885	COG2116	formate transmembrane transporter activity
HX109_RS13890	COG0471	metal ion transport
HX109_RS13890	COG3273	potassium ion transport
HX109_RS13905	COG0401	homolog of Blt101
HX109_RS13920	COG3118	belongs to the thioredoxin family
HX109_RS13935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HX109_RS13940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HX109_RS13945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HX109_RS13950	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS13955	COG3424	synthase
HX109_RS13965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HX109_RS13975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HX109_RS13995	COG3119	arylsulfatase activity
HX109_RS14005	COG2885	chlorophyll binding
HX109_RS14015	COG0022	dehydrogenase e1 component
HX109_RS14045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HX109_RS14050	COG1193	negative regulation of DNA recombination
HX109_RS14060	COG2211	Major facilitator Superfamily
HX109_RS14080	COG0798	PFAM Bile acid sodium symporter
HX109_RS14100	COG0589	response to stress
HX109_RS14130	COG1301	dicarboxylic acid transport
HX109_RS14135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HX109_RS14140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS14150	COG0277	FAD linked oxidase domain protein
HX109_RS14150	COG0247	lactate metabolic process
HX109_RS14160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HX109_RS14165	COG0587	DNA-directed DNA polymerase activity
HX109_RS14175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HX109_RS14185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HX109_RS14190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HX109_RS14215	COG0705	Rhomboid family
HX109_RS14220	COG1560	Kdo2-lipid A biosynthetic process
HX109_RS14225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HX109_RS14230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HX109_RS14245	COG0009	L-threonylcarbamoyladenylate synthase
HX109_RS14260	COG1473	amidohydrolase
HX109_RS14265	COG0069	glutamate synthase activity
HX109_RS14290	COG0424	maF-like protein
HX109_RS14310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HX109_RS14335	COG1702	phosphate starvation-inducible protein PhoH
HX109_RS14355	COG0592	DNA-directed DNA polymerase activity
HX109_RS14365	COG0668	transmembrane transport
HX109_RS14370	COG0783	Belongs to the Dps family
HX109_RS14375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HX109_RS14415	COG0714	Associated with various cellular activities
HX109_RS14430	COG0312	modulator of DNA gyrase
HX109_RS14470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HX109_RS14480	COG0137	argininosuccinate synthase activity
HX109_RS14485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HX109_RS14495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HX109_RS14505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HX109_RS14515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HX109_RS14520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HX109_RS14530	COG0165	Argininosuccinate lyase
HX109_RS14550	COG0673	inositol 2-dehydrogenase activity
HX109_RS14560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HX109_RS14570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HX109_RS14580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HX109_RS14585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HX109_RS14610	COG0012	GTP binding
HX109_RS14615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HX109_RS14620	COG0346	lactoylglutathione lyase activity
HX109_RS14635	COG1047	Peptidyl-prolyl cis-trans
HX109_RS14640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HX109_RS14645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HX109_RS14650	COG0668	transmembrane transport
HX109_RS14665	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS14685	COG1045	serine acetyltransferase
HX109_RS14695	COG0730	response to heat
HX109_RS14700	COG0598	Magnesium transport protein CorA
HX109_RS14705	COG0140	phosphoribosyl-ATP diphosphatase activity
HX109_RS14705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HX109_RS14710	COG0107	imidazoleglycerol-phosphate synthase activity
HX109_RS14715	COG2824	Alkylphosphonate utilization operon protein PhnA
HX109_RS14720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HX109_RS14725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HX109_RS14730	COG0131	Imidazoleglycerol-phosphate dehydratase
HX109_RS14735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HX109_RS14740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HX109_RS14745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HX109_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS14780	COG0612	Peptidase, M16
HX109_RS14785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HX109_RS14795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS14800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HX109_RS14805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS14810	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HX109_RS14810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HX109_RS14815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HX109_RS14820	COG1078	dGTPase activity
HX109_RS14855	COG0802	atpase or kinase
HX109_RS14885	COG4464	protein tyrosine phosphatase activity
HX109_RS14895	COG3206	protein involved in exopolysaccharide biosynthesis
HX109_RS14895	COG0489	protein tyrosine kinase activity
HX109_RS14910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HX109_RS14915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HX109_RS14925	COG5039	Polysaccharide pyruvyl transferase
HX109_RS14930	COG1216	Glycosyl transferase, family 2
HX109_RS14940	COG1216	Glycosyl transferase, family 2
HX109_RS14945	COG5039	Polysaccharide pyruvyl transferase
HX109_RS14955	COG1216	Glycosyl transferase, family 2
HX109_RS14970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HX109_RS14985	COG0701	Predicted permease
HX109_RS14990	COG2217	Heavy metal translocating P-type atpase
HX109_RS15005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HX109_RS15015	COG0010	Belongs to the arginase family
HX109_RS15030	COG0693	protein deglycase activity
HX109_RS15055	COG0149	triose-phosphate isomerase activity
HX109_RS15060	COG2264	protein methyltransferase activity
HX109_RS15075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HX109_RS15075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HX109_RS15080	COG0730	response to heat
HX109_RS15175	COG2323	membrane
HX109_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS15275	COG0492	ferredoxin-NADP+ reductase activity
HX109_RS15460	COG1802	Transcriptional regulator
HX109_RS15460	COG4626	Terminase
HX109_RS15475	COG0305	Participates in initiation and elongation during chromosome replication
HX109_RS15550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HX109_RS15555	COG0626	cystathionine gamma-synthase activity
HX109_RS15565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HX109_RS15565	COG1333	cytochrome c biogenesis protein
HX109_RS15575	COG1505	serine-type exopeptidase activity
HX109_RS15600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HX109_RS15610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HX109_RS15610	COG0072	phenylalanine-tRNA ligase activity
HX109_RS15620	COG1012	belongs to the aldehyde dehydrogenase family
HX109_RS15640	COG2130	NADP-dependent
HX109_RS15645	COG0488	(ABC) transporter
HX109_RS15655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HX109_RS15660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HX109_RS15675	COG4948	Mandelate Racemase Muconate Lactonizing
HX109_RS15680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HX109_RS15700	COG2308	Evidence 4 Homologs of previously reported genes of
HX109_RS15715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HX109_RS15720	COG1393	Belongs to the ArsC family
HX109_RS15750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HX109_RS15760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HX109_RS15770	COG2855	membrane
HX109_RS15775	COG0583	DNA-binding transcription factor activity
HX109_RS15785	COG0076	glutamate decarboxylase activity
HX109_RS15790	COG0259	pyridoxamine-phosphate oxidase activity
HX109_RS15795	COG2154	pterin-4-alpha-carbinolamine dehydratase
HX109_RS15800	COG0217	transcriptional regulatory protein
HX109_RS15810	COG1454	alcohol dehydrogenase
HX109_RS15820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HX109_RS15830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HX109_RS15845	COG0742	ribosomal rna small subunit methyltransferase
HX109_RS15870	COG0706	membrane insertase activity
HX109_RS15875	COG0504	CTP synthase activity
HX109_RS15880	COG3530	Putative quorum-sensing-regulated virulence factor
HX109_RS15900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HX109_RS15910	COG0405	Gamma-glutamyltransferase
HX109_RS15920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HX109_RS15925	COG1611	Belongs to the LOG family
HX109_RS15930	COG2197	response regulator
HX109_RS15935	COG4585	Histidine kinase
HX109_RS15970	COG1984	allophanate hydrolase subunit 2
HX109_RS15975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HX109_RS15985	COG0606	chelatase, subunit chli
HX109_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
HX109_RS16010	COG1760	l-serine dehydratase
HX109_RS16015	COG3325	Belongs to the glycosyl hydrolase 18 family
HX109_RS16015	COG3469	chitinase activity
HX109_RS16020	COG0513	Belongs to the DEAD box helicase family
HX109_RS16030	COG1187	pseudouridine synthase activity
HX109_RS16070	COG4771	TonB-dependent receptor
HX109_RS16080	COG0302	gtp cyclohydrolase
HX109_RS16090	COG3011	Protein conserved in bacteria
HX109_RS16095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HX109_RS16100	COG0857	belongs to the CobB CobQ family
HX109_RS16100	COG0280	phosphate acetyltransferase
HX109_RS16105	COG1228	amidohydrolase
HX109_RS16130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HX109_RS16135	COG1085	galactose-1-phosphate uridylyltransferase
HX109_RS16140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HX109_RS16160	COG0628	permease
HX109_RS16170	COG1609	Transcriptional regulator
HX109_RS16185	COG1312	Catalyzes the dehydration of D-mannonate
HX109_RS16190	COG1904	glucuronate isomerase
HX109_RS16210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component