locus-tag	class	description
DW350_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DW350_RS00020	COG0187	DNA topoisomerase II activity
DW350_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS00025	COG0604	alcohol dehydrogenase
DW350_RS00025	COG3321	synthase
DW350_RS00040	COG0583	DNA-binding transcription factor activity
DW350_RS00055	COG0751	glycine-tRNA ligase activity
DW350_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
DW350_RS00095	COG0425	Belongs to the sulfur carrier protein TusA family
DW350_RS00105	COG0183	Belongs to the thiolase family
DW350_RS00110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW350_RS00110	COG1024	Enoyl-CoA hydratase
DW350_RS00115	COG0006	proline dipeptidase activity
DW350_RS00120	COG1739	Uncharacterized protein family UPF0029
DW350_RS00125	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
DW350_RS00130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DW350_RS00135	COG0569	domain protein
DW350_RS00140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DW350_RS00140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DW350_RS00145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DW350_RS00160	COG0758	DNA mediated transformation
DW350_RS00175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DW350_RS00180	COG0009	L-threonylcarbamoyladenylate synthase
DW350_RS00185	COG0408	coproporphyrinogen oxidase activity
DW350_RS00195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DW350_RS00205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DW350_RS00225	COG1595	DNA-templated transcription, initiation
DW350_RS00255	COG0705	Rhomboid family
DW350_RS00285	COG0655	NAD(P)H dehydrogenase (quinone) activity
DW350_RS00295	COG0742	ribosomal rna small subunit methyltransferase
DW350_RS00300	COG0678	peroxiredoxin activity
DW350_RS00305	COG0668	transmembrane transport
DW350_RS00315	COG2081	HI0933 family
DW350_RS00360	COG0583	DNA-binding transcription factor activity
DW350_RS00365	COG4771	TonB-dependent receptor
DW350_RS00385	COG0840	transmembrane signaling receptor activity
DW350_RS00390	COG0745	RESPONSE REGULATOR receiver
DW350_RS00395	COG1366	Belongs to the anti-sigma-factor antagonist family
DW350_RS00400	COG0643	Histidine kinase
DW350_RS00400	COG2198	Histidine kinase
DW350_RS00410	COG0835	chemotaxis
DW350_RS00415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DW350_RS00420	COG2201	protein-glutamate methylesterase activity
DW350_RS00430	COG0739	heme binding
DW350_RS00435	COG0778	Nitroreductase
DW350_RS00445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DW350_RS00450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DW350_RS00455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DW350_RS00460	COG1758	RNA polymerase activity
DW350_RS00475	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DW350_RS00480	COG2814	Major facilitator Superfamily
DW350_RS00485	COG1566	PFAM secretion protein HlyD family protein
DW350_RS00490	COG1538	Outer membrane efflux protein
DW350_RS00495	COG3104	oligopeptide transport
DW350_RS00500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DW350_RS00505	COG3069	C4-dicarboxylate transmembrane transporter activity
DW350_RS00530	COG3437	response regulator, receiver
DW350_RS00535	COG3850	Histidine kinase
DW350_RS00535	COG3437	response regulator, receiver
DW350_RS00535	COG2205	protein histidine kinase activity
DW350_RS00535	COG4999	Histidine kinase
DW350_RS00550	COG1561	YicC-like family, N-terminal region
DW350_RS00555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DW350_RS00565	COG4774	siderophore transport
DW350_RS00575	COG1309	transcriptional regulator
DW350_RS00580	COG0756	dUTP diphosphatase activity
DW350_RS00585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DW350_RS00595	COG2003	Belongs to the UPF0758 family
DW350_RS00600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DW350_RS00605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DW350_RS00615	COG1469	GTP cyclohydrolase I activity
DW350_RS00620	COG4451	ribulose bisphosphate carboxylase, small
DW350_RS00620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DW350_RS00625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DW350_RS00640	COG1216	Glycosyl transferase, family 2
DW350_RS00655	COG1442	glycosyl transferase family 8
DW350_RS00655	COG1216	Glycosyl transferase, family 2
DW350_RS00670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DW350_RS00675	COG0840	transmembrane signaling receptor activity
DW350_RS00685	COG0463	Glycosyl transferase, family 2
DW350_RS00695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW350_RS00710	COG1063	alcohol dehydrogenase
DW350_RS00715	COG0438	transferase activity, transferring glycosyl groups
DW350_RS00720	COG3706	GGDEF domain
DW350_RS00725	COG1609	Transcriptional regulator
DW350_RS00730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DW350_RS00735	COG0705	Rhomboid family
DW350_RS00740	COG1580	Controls the rotational direction of flagella during chemotaxis
DW350_RS00745	COG3161	chorismate lyase activity
DW350_RS00760	COG2937	Belongs to the GPAT DAPAT family
DW350_RS00770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DW350_RS00790	COG0346	lactoylglutathione lyase activity
DW350_RS00800	COG0788	formyltetrahydrofolate deformylase activity
DW350_RS00815	COG2116	formate transmembrane transporter activity
DW350_RS00825	COG1335	isochorismatase
DW350_RS00845	COG0308	aminopeptidase N
DW350_RS00850	COG0811	peptide transport
DW350_RS00870	COG0534	Mate efflux family protein
DW350_RS00880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DW350_RS00880	COG0316	Belongs to the HesB IscA family
DW350_RS00910	COG1538	Outer membrane efflux protein
DW350_RS00920	COG0596	Alpha beta hydrolase
DW350_RS00930	COG2183	response to ionizing radiation
DW350_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DW350_RS00950	COG1966	Carbon starvation protein
DW350_RS00960	COG0003	Pfam Anion-transporting ATPase
DW350_RS01010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DW350_RS01015	COG1404	Belongs to the peptidase S8 family
DW350_RS01020	COG1404	Belongs to the peptidase S8 family
DW350_RS01025	COG1404	Belongs to the peptidase S8 family
DW350_RS01045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DW350_RS01050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DW350_RS01055	COG3031	protein transport across the cell outer membrane
DW350_RS01065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DW350_RS01070	COG1459	type II secretion system
DW350_RS01075	COG2165	general secretion pathway protein
DW350_RS01090	COG4795	General secretion pathway protein
DW350_RS01095	COG3156	type II secretion system protein K
DW350_RS01115	COG1011	Hydrolase
DW350_RS01120	COG0494	nUDIX hydrolase
DW350_RS01125	COG1218	3'(2'),5'-bisphosphate nucleotidase
DW350_RS01160	COG3263	regulation of cellular component size
DW350_RS01170	COG1757	Na H antiporter
DW350_RS01180	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW350_RS01185	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW350_RS01205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DW350_RS01230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DW350_RS01240	COG0724	RNA recognition motif
DW350_RS01280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DW350_RS01285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DW350_RS01285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DW350_RS01290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DW350_RS01310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DW350_RS01315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DW350_RS01320	COG0250	Participates in transcription elongation, termination and antitermination
DW350_RS01325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DW350_RS01330	COG0081	regulation of translation
DW350_RS01335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DW350_RS01340	COG0222	ribosome binding
DW350_RS01345	COG0085	RNA polymerase activity
DW350_RS01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DW350_RS01360	COG0049	tRNA binding
DW350_RS01365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DW350_RS01370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DW350_RS01375	COG0051	transcription antitermination factor activity, RNA binding
DW350_RS01380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DW350_RS01385	COG0088	Forms part of the polypeptide exit tunnel
DW350_RS01390	COG0089	rRNA binding
DW350_RS01395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DW350_RS01400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DW350_RS01405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DW350_RS01410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DW350_RS01415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DW350_RS01430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DW350_RS01435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DW350_RS01440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DW350_RS01450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DW350_RS01455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DW350_RS01460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DW350_RS01465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DW350_RS01470	COG1841	ribosomal large subunit assembly
DW350_RS01475	COG0200	Binds to the 23S rRNA
DW350_RS01480	COG0201	protein transport
DW350_RS01485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DW350_RS01490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DW350_RS01495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DW350_RS01505	COG0202	RNA polymerase activity
DW350_RS01510	COG0203	ribosomal protein L17
DW350_RS01585	COG2201	protein-glutamate methylesterase activity
DW350_RS01600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DW350_RS01605	COG0861	Integral membrane protein TerC family
DW350_RS01615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DW350_RS01625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DW350_RS01630	COG0137	argininosuccinate synthase activity
DW350_RS01635	COG0165	Argininosuccinate lyase
DW350_RS01635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DW350_RS01640	COG2205	protein histidine kinase activity
DW350_RS01645	COG0745	RESPONSE REGULATOR receiver
DW350_RS01690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DW350_RS01695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DW350_RS01705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DW350_RS01720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DW350_RS01725	COG0546	phosphoglycolate phosphatase activity
DW350_RS01735	COG4773	Receptor
DW350_RS01750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DW350_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS01775	COG0714	Associated with various cellular activities
DW350_RS01790	COG1444	tRNA N-acetyltransferase activity
DW350_RS01800	COG1765	OsmC-like protein
DW350_RS01805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DW350_RS01820	COG2814	Major facilitator Superfamily
DW350_RS01825	COG1566	PFAM secretion protein HlyD family protein
DW350_RS01835	COG2204	response regulator
DW350_RS01840	COG3852	Histidine kinase
DW350_RS01845	COG1271	oxidase subunit
DW350_RS01850	COG1294	oxidase, subunit
DW350_RS01865	COG2814	Major facilitator Superfamily
DW350_RS01890	COG2153	protein acetylation
DW350_RS01895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DW350_RS01900	COG3954	Phosphoribulokinase
DW350_RS01905	COG3089	Belongs to the UPF0270 family
DW350_RS01920	COG0429	hydrolase of the alpha beta-hydrolase fold
DW350_RS01925	COG2133	pyrroloquinoline quinone binding
DW350_RS01935	COG4772	TonB-dependent receptor
DW350_RS01950	COG0583	DNA-binding transcription factor activity
DW350_RS01975	COG0837	glucose binding
DW350_RS01980	COG2814	Major facilitator Superfamily
DW350_RS01995	COG0488	(ABC) transporter
DW350_RS02000	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DW350_RS02015	COG0545	Peptidyl-prolyl cis-trans isomerase
DW350_RS02030	COG3788	relative of glutathione S-transferase, MAPEG superfamily
DW350_RS02045	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DW350_RS02050	COG2816	NAD+ diphosphatase activity
DW350_RS02060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DW350_RS02065	COG5001	Diguanylate cyclase
DW350_RS02065	COG5002	protein histidine kinase activity
DW350_RS02065	COG3447	MASE1 domain protein
DW350_RS02075	COG1454	alcohol dehydrogenase
DW350_RS02080	COG2207	Transcriptional regulator
DW350_RS02080	COG1917	Cupin 2, conserved barrel domain protein
DW350_RS02090	COG0436	Aminotransferase
DW350_RS02100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DW350_RS02110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DW350_RS02115	COG0739	heme binding
DW350_RS02125	COG1573	uracil-dna glycosylase
DW350_RS02135	COG1741	Belongs to the pirin family
DW350_RS02155	COG1960	acyl-CoA dehydrogenase activity
DW350_RS02165	COG0367	asparagine synthase
DW350_RS02195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DW350_RS02200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DW350_RS02205	COG0126	phosphoglycerate kinase activity
DW350_RS02210	COG0191	fructose-bisphosphate aldolase activity
DW350_RS02235	COG2274	protein secretion by the type I secretion system
DW350_RS02240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS02245	COG1538	Outer membrane efflux protein
DW350_RS02265	COG1560	Kdo2-lipid A biosynthetic process
DW350_RS02270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DW350_RS02275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DW350_RS02280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DW350_RS02290	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DW350_RS02300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW350_RS02305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW350_RS02310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DW350_RS02315	COG0509	glycine decarboxylation via glycine cleavage system
DW350_RS02320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW350_RS02320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW350_RS02370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DW350_RS02375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DW350_RS02385	COG3634	alkyl hydroperoxide reductase activity
DW350_RS02390	COG0450	alkyl hydroperoxide reductase
DW350_RS02400	COG0840	transmembrane signaling receptor activity
DW350_RS02425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DW350_RS02430	COG1764	response to oxidative stress
DW350_RS02435	COG1846	Transcriptional regulator
DW350_RS02475	COG4232	protein-disulfide reductase activity
DW350_RS02525	COG1629	transport
DW350_RS02525	COG4771	TonB-dependent receptor
DW350_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS02545	COG0583	DNA-binding transcription factor activity
DW350_RS02550	COG0667	Aldo Keto reductase
DW350_RS02555	COG3706	GGDEF domain
DW350_RS02575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DW350_RS02585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DW350_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW350_RS02600	COG3152	Membrane
DW350_RS02620	COG1511	domain protein
DW350_RS02620	COG3264	Mechanosensitive ion channel
DW350_RS02630	COG0688	phosphatidylethanolamine metabolic process
DW350_RS02635	COG1162	GTPase activity
DW350_RS02640	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DW350_RS02660	COG5002	protein histidine kinase activity
DW350_RS02660	COG2205	protein histidine kinase activity
DW350_RS02660	COG0784	Response regulator, receiver
DW350_RS02670	COG3511	phospholipase C
DW350_RS02695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DW350_RS02695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DW350_RS02700	COG0802	atpase or kinase
DW350_RS02705	COG0860	N-Acetylmuramoyl-L-alanine amidase
DW350_RS02710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DW350_RS02715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DW350_RS02720	COG1923	regulation of RNA biosynthetic process
DW350_RS02725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DW350_RS02730	COG0330	HflC and HflK could
DW350_RS02735	COG0330	HflC and HflK could
DW350_RS02750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DW350_RS02755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DW350_RS02760	COG3083	sulfuric ester hydrolase activity
DW350_RS02770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DW350_RS02780	COG0360	Binds together with S18 to 16S ribosomal RNA
DW350_RS02785	COG2965	DNA replication, synthesis of RNA primer
DW350_RS02790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DW350_RS02795	COG0359	binds to the 23S rRNA
DW350_RS02800	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DW350_RS02805	COG3066	DNA modification
DW350_RS02810	COG0494	nUDIX hydrolase
DW350_RS02815	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
DW350_RS02825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DW350_RS02835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DW350_RS02845	COG0583	DNA-binding transcription factor activity
DW350_RS02855	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW350_RS02860	COG0640	Transcriptional regulator
DW350_RS02865	COG0268	Binds directly to 16S ribosomal RNA
DW350_RS02870	COG0728	peptidoglycan biosynthetic process
DW350_RS02875	COG0196	riboflavin kinase activity
DW350_RS02880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DW350_RS02885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DW350_RS02890	COG1047	Peptidyl-prolyl cis-trans
DW350_RS02895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DW350_RS02905	COG4966	pilus assembly protein PilW
DW350_RS02965	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DW350_RS02970	COG0564	pseudouridine synthase activity
DW350_RS02975	COG1496	oxidoreductase activity
DW350_RS02980	COG0542	response to heat
DW350_RS02990	COG1183	phosphatidylcholine synthase activity
DW350_RS03040	COG0456	acetyltransferase
DW350_RS03045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DW350_RS03050	COG0084	hydrolase, TatD family'
DW350_RS03055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DW350_RS03080	COG0560	Phosphoserine phosphatase
DW350_RS03110	COG0488	(ABC) transporter
DW350_RS03115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DW350_RS03120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DW350_RS03125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW350_RS03125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW350_RS03145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DW350_RS03150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DW350_RS03155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DW350_RS03165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DW350_RS03170	COG0142	geranyltranstransferase activity
DW350_RS03180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DW350_RS03185	COG1360	Flagellar Motor Protein
DW350_RS03185	COG1360	Flagellar Motor Protein
DW350_RS03190	COG0301	tRNA thio-modification
DW350_RS03190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DW350_RS03195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DW350_RS03205	COG2814	Major facilitator Superfamily
DW350_RS03215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DW350_RS03235	COG2813	Specifically methylates the guanine in position
DW350_RS03245	COG0271	Belongs to the BolA IbaG family
DW350_RS03255	COG1805	sodium ion transport
DW350_RS03260	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW350_RS03265	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW350_RS03270	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW350_RS03275	COG2871	sodium ion transport
DW350_RS03280	COG1477	protein flavinylation
DW350_RS03315	COG4191	Histidine kinase
DW350_RS03320	COG2204	response regulator
DW350_RS03325	COG1944	ATP diphosphatase activity
DW350_RS03335	COG1671	Belongs to the UPF0178 family
DW350_RS03340	COG2194	sulfuric ester hydrolase activity
DW350_RS03350	COG0435	Glutathione S-transferase
DW350_RS03355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DW350_RS03360	COG0569	domain protein
DW350_RS03375	COG3784	Protein of unknown function (DUF1318)
DW350_RS03385	COG2186	Transcriptional regulator
DW350_RS03395	COG3507	Belongs to the glycosyl hydrolase 43 family
DW350_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS03420	COG1879	ABC-type sugar transport system periplasmic component
DW350_RS03425	COG1129	ABC transporter
DW350_RS03430	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW350_RS03435	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW350_RS03440	COG3386	PFAM SMP-30 Gluconolaconase
DW350_RS03445	COG3940	Belongs to the glycosyl hydrolase 43 family
DW350_RS03465	COG4771	TonB-dependent receptor
DW350_RS03475	COG1846	Transcriptional regulator
DW350_RS03485	COG1566	PFAM secretion protein HlyD family protein
DW350_RS03490	COG2814	Major facilitator Superfamily
DW350_RS03500	COG2610	gluconate transmembrane transporter activity
DW350_RS03515	COG2814	Major facilitator Superfamily
DW350_RS03540	COG3940	Belongs to the glycosyl hydrolase 43 family
DW350_RS03545	COG2211	Major facilitator Superfamily
DW350_RS03550	COG3507	Belongs to the glycosyl hydrolase 43 family
DW350_RS03555	COG1082	Xylose isomerase domain protein TIM barrel
DW350_RS03560	COG3940	Belongs to the glycosyl hydrolase 43 family
DW350_RS03575	COG1597	lipid kinase activity
DW350_RS03585	COG0642	Histidine kinase
DW350_RS03590	COG0745	RESPONSE REGULATOR receiver
DW350_RS03605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DW350_RS03610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW350_RS03615	COG1120	ATPase activity
DW350_RS03620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DW350_RS03650	COG2226	methyltransferase
DW350_RS03660	COG0217	transcriptional regulatory protein
DW350_RS03670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DW350_RS03695	COG0583	DNA-binding transcription factor activity
DW350_RS03710	COG0842	Transport permease protein
DW350_RS03715	COG0842	Transport permease protein
DW350_RS03720	COG1131	(ABC) transporter
DW350_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS03735	COG3038	cytochrome b561
DW350_RS03740	COG0753	catalase activity
DW350_RS03770	COG3321	synthase
DW350_RS03770	COG0604	alcohol dehydrogenase
DW350_RS03785	COG0825	malonyl-CoA metabolic process
DW350_RS03785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DW350_RS03790	COG3052	prosthetic group binding
DW350_RS03795	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DW350_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS03815	COG2207	Transcriptional regulator
DW350_RS03835	COG0697	spore germination
DW350_RS03850	COG3008	intermembrane lipid transfer
DW350_RS03850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DW350_RS03855	COG2995	paraquat-inducible protein a
DW350_RS03870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DW350_RS03875	COG4221	oxidoreductase activity
DW350_RS03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS03900	COG0500	methyltransferase
DW350_RS03905	COG0604	alcohol dehydrogenase
DW350_RS03910	COG1309	transcriptional regulator
DW350_RS03955	COG1584	GPR1 FUN34 yaaH family protein
DW350_RS03970	COG2431	L-lysine efflux transmembrane transporter activity
DW350_RS03985	COG0358	DNA primase activity
DW350_RS03990	COG1610	YqeY-like protein
DW350_RS03995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DW350_RS04000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DW350_RS04010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DW350_RS04015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DW350_RS04020	COG0617	tRNA 3'-terminal CCA addition
DW350_RS04025	COG3409	Peptidoglycan-binding domain 1 protein
DW350_RS04025	COG3267	Type II secretory pathway component ExeA
DW350_RS04050	COG1811	Na channel or pump
DW350_RS04065	COG4991	sh3 domain protein
DW350_RS04070	COG0306	phosphate transporter
DW350_RS04075	COG1392	Phosphate transport regulator
DW350_RS04080	COG3025	triphosphatase activity
DW350_RS04085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DW350_RS04100	COG3789	protein conserved in bacteria
DW350_RS04110	COG1560	Kdo2-lipid A biosynthetic process
DW350_RS04115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DW350_RS04115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DW350_RS04120	COG1519	Transferase
DW350_RS04125	COG1538	Outer membrane efflux protein
DW350_RS04130	COG0494	nUDIX hydrolase
DW350_RS04140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DW350_RS04145	COG3150	esterase
DW350_RS04150	COG0187	DNA topoisomerase II activity
DW350_RS04155	COG5001	Diguanylate cyclase
DW350_RS04155	COG5002	protein histidine kinase activity
DW350_RS04160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DW350_RS04165	COG3642	lipopolysaccharide core region biosynthetic process
DW350_RS04170	COG0859	PFAM glycosyl transferase family 9
DW350_RS04180	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
DW350_RS04190	COG2814	Major facilitator Superfamily
DW350_RS04210	COG5001	Diguanylate cyclase
DW350_RS04220	COG2927	DNA polymerase III (CHI subunit)
DW350_RS04225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW350_RS04230	COG0795	lipopolysaccharide-transporting ATPase activity
DW350_RS04235	COG0795	lipopolysaccharide-transporting ATPase activity
DW350_RS04240	COG0095	Lipoate-protein ligase
DW350_RS04265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DW350_RS04270	COG1785	Belongs to the alkaline phosphatase family
DW350_RS04280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DW350_RS04300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DW350_RS04310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DW350_RS04315	COG0745	RESPONSE REGULATOR receiver
DW350_RS04320	COG5002	protein histidine kinase activity
DW350_RS04340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DW350_RS04350	COG0573	inorganic phosphate transmembrane transporter activity
DW350_RS04355	COG0581	inorganic phosphate transmembrane transporter activity
DW350_RS04360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DW350_RS04365	COG0704	Plays a role in the regulation of phosphate uptake
DW350_RS04385	COG0583	DNA-binding transcription factor activity
DW350_RS04390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DW350_RS04395	COG2224	Isocitrate lyase
DW350_RS04405	COG0318	PFAM AMP-dependent synthetase and ligase
DW350_RS04410	COG0300	oxidoreductase activity
DW350_RS04425	COG0642	Histidine kinase
DW350_RS04430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DW350_RS04435	COG0343	queuine tRNA-ribosyltransferase activity
DW350_RS04440	COG1862	Preprotein translocase
DW350_RS04445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DW350_RS04450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DW350_RS04460	COG1368	sulfuric ester hydrolase activity
DW350_RS04465	COG0483	inositol monophosphate 1-phosphatase activity
DW350_RS04470	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DW350_RS04490	COG0822	iron-sulfur transferase activity
DW350_RS04495	COG0316	Belongs to the HesB IscA family
DW350_RS04500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DW350_RS04505	COG0443	Heat shock 70 kDa protein
DW350_RS04510	COG0633	Ferredoxin
DW350_RS04515	COG2975	iron-sulfur cluster assembly
DW350_RS04520	COG0105	UTP biosynthetic process
DW350_RS04525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DW350_RS04535	COG1426	Protein conserved in bacteria
DW350_RS04540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DW350_RS04545	COG0124	histidyl-tRNA synthetase
DW350_RS04550	COG2976	Protein conserved in bacteria
DW350_RS04560	COG1160	GTP binding
DW350_RS04575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS04585	COG2957	Belongs to the agmatine deiminase family
DW350_RS04595	COG1570	exodeoxyribonuclease VII activity
DW350_RS04600	COG0516	GMP reductase activity
DW350_RS04600	COG0517	IMP dehydrogenase activity
DW350_RS04605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DW350_RS04605	COG0519	Catalyzes the synthesis of GMP from XMP
DW350_RS04630	COG0445	tRNA wobble uridine modification
DW350_RS04635	COG1309	transcriptional regulator
DW350_RS04650	COG3321	synthase
DW350_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS04650	COG0604	alcohol dehydrogenase
DW350_RS04655	COG0667	Aldo Keto reductase
DW350_RS04680	COG1733	regulation of RNA biosynthetic process
DW350_RS04710	COG0583	DNA-binding transcription factor activity
DW350_RS04720	COG4221	oxidoreductase activity
DW350_RS04735	COG0583	DNA-binding transcription factor activity
DW350_RS04770	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS04835	COG0604	alcohol dehydrogenase
DW350_RS04860	COG0477	Major facilitator Superfamily
DW350_RS04865	COG0823	Involved in the tonB-independent uptake of proteins
DW350_RS04880	COG2814	Major facilitator Superfamily
DW350_RS04890	COG0612	Peptidase, M16
DW350_RS04895	COG0667	Aldo Keto reductase
DW350_RS04900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DW350_RS04915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DW350_RS04915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DW350_RS04930	COG0735	belongs to the Fur family
DW350_RS04935	COG1695	Transcriptional regulator
DW350_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS04990	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DW350_RS05005	COG2084	Dehydrogenase
DW350_RS05010	COG0583	DNA-binding transcription factor activity
DW350_RS05015	COG1380	Effector of murein hydrolase LrgA
DW350_RS05020	COG1346	cytolysis
DW350_RS05035	COG3284	Transcriptional regulator
DW350_RS05055	COG0418	dihydroorotase activity
DW350_RS05060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DW350_RS05070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DW350_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS05120	COG0590	tRNA wobble adenosine to inosine editing
DW350_RS05125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DW350_RS05130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DW350_RS05130	COG0047	phosphoribosylformylglycinamidine synthase activity
DW350_RS05150	COG1902	pentaerythritol trinitrate reductase activity
DW350_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS05225	COG1858	cytochrome C peroxidase
DW350_RS05230	COG0860	N-Acetylmuramoyl-L-alanine amidase
DW350_RS05245	COG0251	oxidation-reduction process
DW350_RS05250	COG0745	RESPONSE REGULATOR receiver
DW350_RS05255	COG2205	protein histidine kinase activity
DW350_RS05275	COG0676	glucose-6-phosphate 1-epimerase activity
DW350_RS05285	COG0517	IMP dehydrogenase activity
DW350_RS05295	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DW350_RS05305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DW350_RS05310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DW350_RS05315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DW350_RS05320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DW350_RS05325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DW350_RS05335	COG2912	Transglutaminase-like superfamily
DW350_RS05340	COG5505	Protein of unknown function (DUF819)
DW350_RS05345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DW350_RS05350	COG3479	Phenolic acid decarboxylase
DW350_RS05355	COG0583	DNA-binding transcription factor activity
DW350_RS05365	COG0583	DNA-binding transcription factor activity
DW350_RS05380	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DW350_RS05410	COG0372	Belongs to the citrate synthase family
DW350_RS05420	COG0454	-acetyltransferase
DW350_RS05460	COG0583	DNA-binding transcription factor activity
DW350_RS05470	COG3046	protein related to deoxyribodipyrimidine photolyase
DW350_RS05505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DW350_RS05520	COG5001	Diguanylate cyclase
DW350_RS05545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DW350_RS05565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DW350_RS05570	COG2205	protein histidine kinase activity
DW350_RS05575	COG0745	RESPONSE REGULATOR receiver
DW350_RS05580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS05590	COG1538	Outer membrane efflux protein
DW350_RS05595	COG3148	PFAM DTW domain containing protein
DW350_RS05600	COG0473	3-isopropylmalate dehydrogenase activity
DW350_RS05615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DW350_RS05620	COG1611	Belongs to the LOG family
DW350_RS05650	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DW350_RS05675	COG3098	single-species biofilm formation
DW350_RS05680	COG0564	pseudouridine synthase activity
DW350_RS05690	COG1263	PTS System
DW350_RS05690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DW350_RS05700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DW350_RS05705	COG0024	Methionine aminopeptidase
DW350_RS05710	COG0052	Belongs to the universal ribosomal protein uS2 family
DW350_RS05715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DW350_RS05720	COG0528	UMP kinase activity
DW350_RS05725	COG0233	cytoplasmic translational termination
DW350_RS05730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DW350_RS05735	COG0575	Belongs to the CDS family
DW350_RS05740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DW350_RS05745	COG0750	zinc metalloprotease
DW350_RS05765	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW350_RS05770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DW350_RS05775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW350_RS05780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW350_RS05785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DW350_RS05795	COG0825	malonyl-CoA metabolic process
DW350_RS05800	COG0037	tRNA processing
DW350_RS05805	COG2203	Gaf domain
DW350_RS05805	COG2199	diguanylate cyclase activity
DW350_RS05830	COG1720	tRNA m6t6A37 methyltransferase activity
DW350_RS05845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DW350_RS05890	COG0500	methyltransferase
DW350_RS05900	COG1801	Protein of unknown function DUF72
DW350_RS05905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DW350_RS05915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DW350_RS05920	COG0632	four-way junction helicase activity
DW350_RS05925	COG2255	four-way junction helicase activity
DW350_RS05930	COG0729	surface antigen
DW350_RS05935	COG2911	Protein conserved in bacteria
DW350_RS05945	COG1505	serine-type exopeptidase activity
DW350_RS05950	COG0824	Thioesterase
DW350_RS05955	COG0811	peptide transport
DW350_RS05970	COG0823	Involved in the tonB-independent uptake of proteins
DW350_RS05975	COG2885	chlorophyll binding
DW350_RS05980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DW350_RS06005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DW350_RS06025	COG0492	ferredoxin-NADP+ reductase activity
DW350_RS06030	COG3118	belongs to the thioredoxin family
DW350_RS06035	COG2814	Major facilitator Superfamily
DW350_RS06040	COG1309	transcriptional regulator
DW350_RS06055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DW350_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS06085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DW350_RS06090	COG1280	lysine exporter protein (LysE YggA)
DW350_RS06100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DW350_RS06110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DW350_RS06120	COG0564	pseudouridine synthase activity
DW350_RS06140	COG0123	including yeast histone deacetylase and acetoin utilization protein
DW350_RS06145	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DW350_RS06155	COG1199	ATP-dependent helicase activity
DW350_RS06160	COG4206	TonB-dependent receptor
DW350_RS06170	COG0811	peptide transport
DW350_RS06175	COG0811	peptide transport
DW350_RS06180	COG0848	biopolymer transport protein
DW350_RS06205	COG4206	TonB-dependent receptor
DW350_RS06220	COG1605	Chorismate mutase
DW350_RS06220	COG0077	Prephenate dehydratase
DW350_RS06230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DW350_RS06240	COG3220	belongs to the UPF0276 family
DW350_RS06250	COG2832	Protein of unknown function (DUF454)
DW350_RS06260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DW350_RS06265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DW350_RS06270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DW350_RS06275	COG0326	Molecular chaperone. Has ATPase activity
DW350_RS06285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DW350_RS06290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW350_RS06315	COG0596	Alpha beta hydrolase
DW350_RS06330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DW350_RS06330	COG0140	phosphoribosyl-ATP diphosphatase activity
DW350_RS06335	COG0107	imidazoleglycerol-phosphate synthase activity
DW350_RS06340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DW350_RS06345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DW350_RS06350	COG0131	Imidazoleglycerol-phosphate dehydratase
DW350_RS06350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DW350_RS06360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DW350_RS06375	COG1199	ATP-dependent helicase activity
DW350_RS06380	COG1214	PFAM Peptidase M22, glycoprotease
DW350_RS06395	COG3065	identical protein binding
DW350_RS06405	COG0318	PFAM AMP-dependent synthetase and ligase
DW350_RS06410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DW350_RS06415	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DW350_RS06420	COG2894	cell division
DW350_RS06430	COG3100	YcgL domain-containing protein
DW350_RS06435	COG2951	lytic endotransglycosylase activity
DW350_RS06440	COG2983	Belongs to the UPF0260 family
DW350_RS06445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DW350_RS06450	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DW350_RS06455	COG2186	Transcriptional regulator
DW350_RS06460	COG2719	SpoVR family
DW350_RS06465	COG2718	Belongs to the UPF0229 family
DW350_RS06470	COG2766	serine protein kinase
DW350_RS06485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DW350_RS06490	COG2056	Na+-H+ antiporter family
DW350_RS06495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS06500	COG1129	ABC transporter
DW350_RS06500	COG0842	Transport permease protein
DW350_RS06505	COG0842	Transport permease protein
DW350_RS06510	COG3180	Ammonia monooxygenase
DW350_RS06525	COG0189	ligase activity
DW350_RS06535	COG0527	aspartate kinase activity
DW350_RS06540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DW350_RS06545	COG2885	chlorophyll binding
DW350_RS06555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DW350_RS06560	COG4660	Part of a membrane complex involved in electron transport
DW350_RS06565	COG4659	FMN binding
DW350_RS06570	COG4658	electron transport chain
DW350_RS06575	COG4656	Part of a membrane complex involved in electron transport
DW350_RS06580	COG2878	Part of a membrane complex involved in electron transport
DW350_RS06585	COG4657	Part of a membrane complex involved in electron transport
DW350_RS06595	COG2203	Gaf domain
DW350_RS06595	COG2199	diguanylate cyclase activity
DW350_RS06595	COG2200	EAL domain
DW350_RS06620	COG0556	nucleotide-excision repair
DW350_RS06655	COG0596	Alpha beta hydrolase
DW350_RS06675	COG0720	synthase
DW350_RS06685	COG0602	queuosine metabolic process
DW350_RS06730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DW350_RS06740	COG1196	nuclear chromosome segregation
DW350_RS06745	COG3115	cell septum assembly
DW350_RS06750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DW350_RS06765	COG0814	amino acid
DW350_RS06855	COG0531	amino acid
DW350_RS06860	COG0069	glutamate synthase activity
DW350_RS06870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DW350_RS06875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DW350_RS06880	COG3345	alpha-galactosidase
DW350_RS06955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DW350_RS06975	COG1984	allophanate hydrolase subunit 2
DW350_RS06980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DW350_RS06985	COG4181	ATPase activity
DW350_RS06990	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DW350_RS07010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS07020	COG1937	Protein conserved in bacteria
DW350_RS07050	COG2197	response regulator
DW350_RS07055	COG1278	Cold shock
DW350_RS07090	COG1090	epimerase
DW350_RS07095	COG0628	permease
DW350_RS07110	COG0741	lytic transglycosylase activity
DW350_RS07110	COG1388	LysM domain
DW350_RS07115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DW350_RS07120	COG2226	methyltransferase
DW350_RS07170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DW350_RS07175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS07185	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DW350_RS07195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DW350_RS07205	COG0121	glutamine amidotransferase
DW350_RS07215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DW350_RS07220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DW350_RS07225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DW350_RS07245	COG1393	Belongs to the ArsC family
DW350_RS07250	COG4783	chaperone-mediated protein folding
DW350_RS07270	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DW350_RS07275	COG1132	(ABC) transporter
DW350_RS07285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DW350_RS07290	COG2716	regulation of RNA biosynthetic process
DW350_RS07295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DW350_RS07300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DW350_RS07330	COG0385	Bile acid
DW350_RS07335	COG0583	DNA-binding transcription factor activity
DW350_RS07350	COG1064	alcohol dehydrogenase
DW350_RS07355	COG2207	Transcriptional regulator
DW350_RS07365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DW350_RS07370	COG1393	Belongs to the ArsC family
DW350_RS07380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DW350_RS07385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DW350_RS07395	COG4771	TonB-dependent receptor
DW350_RS07415	COG2067	long-chain fatty acid transport protein
DW350_RS07435	COG2304	oxidoreductase activity
DW350_RS07455	COG0714	Associated with various cellular activities
DW350_RS07460	COG0183	Belongs to the thiolase family
DW350_RS07465	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW350_RS07465	COG1024	Enoyl-CoA hydratase
DW350_RS07485	COG2062	phosphohistidine phosphatase, SixA
DW350_RS07490	COG2840	Smr protein MutS2
DW350_RS07500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DW350_RS07505	COG3101	peptidyl-lysine hydroxylation
DW350_RS07520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW350_RS07520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DW350_RS07530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DW350_RS07535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DW350_RS07550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DW350_RS07555	COG0285	dihydrofolate synthase activity
DW350_RS07560	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DW350_RS07565	COG1286	toxin biosynthetic process
DW350_RS07570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DW350_RS07590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW350_RS07595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DW350_RS07600	COG0215	cysteine-tRNA ligase activity
DW350_RS07605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DW350_RS07610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DW350_RS07615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DW350_RS07635	COG0544	peptidyl-prolyl cis-trans isomerase activity
DW350_RS07640	COG0740	serine-type endopeptidase activity
DW350_RS07650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DW350_RS07655	COG0776	regulation of translation
DW350_RS07665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DW350_RS07675	COG0436	Aminotransferase
DW350_RS07680	COG0235	Class ii aldolase
DW350_RS07685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DW350_RS07715	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DW350_RS07720	COG4172	Belongs to the ABC transporter superfamily
DW350_RS07730	COG4171	peptide transport system, permease
DW350_RS07735	COG0601	transmembrane transport
DW350_RS07740	COG0747	negative chemotaxis
DW350_RS07745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DW350_RS07750	COG1842	Phage shock protein A
DW350_RS07765	COG3106	COG3106 Predicted ATPase
DW350_RS07780	COG2154	pterin-4-alpha-carbinolamine dehydratase
DW350_RS07810	COG1335	isochorismatase
DW350_RS07845	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DW350_RS07855	COG0625	glutathione transferase activity
DW350_RS07870	COG3384	dioxygenase
DW350_RS07880	COG0583	DNA-binding transcription factor activity
DW350_RS07885	COG0564	pseudouridine synthase activity
DW350_RS07890	COG3214	Protein conserved in bacteria
DW350_RS07925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DW350_RS07935	COG0778	Nitroreductase
DW350_RS07940	COG2814	Major facilitator Superfamily
DW350_RS07965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DW350_RS07970	COG1793	dna ligase
DW350_RS07975	COG1278	Cold shock
DW350_RS08005	COG0523	cobalamin synthesis protein
DW350_RS08010	COG3099	Belongs to the UPF0263 family
DW350_RS08015	COG0735	belongs to the Fur family
DW350_RS08020	COG0840	transmembrane signaling receptor activity
DW350_RS08040	COG0840	transmembrane signaling receptor activity
DW350_RS08045	COG2375	cellular response to nickel ion
DW350_RS08055	COG0738	Major facilitator superfamily
DW350_RS08075	COG0339	signal peptide processing
DW350_RS08080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DW350_RS08085	COG0339	signal peptide processing
DW350_RS08095	COG0835	chemotaxis
DW350_RS08095	COG0784	Response regulator, receiver
DW350_RS08100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DW350_RS08110	COG0076	glutamate decarboxylase activity
DW350_RS08115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DW350_RS08130	COG3485	protocatechuate 3,4-dioxygenase
DW350_RS08140	COG4948	Mandelate Racemase Muconate Lactonizing
DW350_RS08150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DW350_RS08175	COG2027	D-alanyl-D-alanine carboxypeptidase
DW350_RS08180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DW350_RS08185	COG0307	riboflavin synthase, alpha
DW350_RS08200	COG0668	transmembrane transport
DW350_RS08215	COG1304	FMN binding
DW350_RS08225	COG1794	racemase activity, acting on amino acids and derivatives
DW350_RS08240	COG1477	protein flavinylation
DW350_RS08265	COG0393	Putative heavy-metal-binding
DW350_RS08275	COG4895	conserved protein (DUF2196)
DW350_RS08290	COG2801	Transposase and inactivated derivatives
DW350_RS08295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DW350_RS08325	COG3416	Protein conserved in bacteria
DW350_RS08350	COG3153	acetyltransferase
DW350_RS08350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DW350_RS08360	COG2814	Major facilitator Superfamily
DW350_RS08375	COG0803	Belongs to the bacterial solute-binding protein 9 family
DW350_RS08380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DW350_RS08400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DW350_RS08405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DW350_RS08420	COG2866	Carboxypeptidase
DW350_RS08425	COG1115	amino acid carrier protein
DW350_RS08435	COG3139	Protein of unknown function (DUF1315)
DW350_RS08445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DW350_RS08450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DW350_RS08455	COG1272	protein, Hemolysin III
DW350_RS08465	COG0436	Aminotransferase
DW350_RS08470	COG0252	asparaginase activity
DW350_RS08475	COG0616	signal peptide processing
DW350_RS08480	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW350_RS08480	COG1902	pentaerythritol trinitrate reductase activity
DW350_RS08495	COG0716	FMN binding
DW350_RS08505	COG0596	Alpha beta hydrolase
DW350_RS08510	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DW350_RS08515	COG0033	Phosphoglucomutase
DW350_RS08520	COG2988	succinylglutamate desuccinylase activity
DW350_RS08525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DW350_RS08540	COG0583	DNA-binding transcription factor activity
DW350_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS08575	COG3541	Predicted nucleotidyltransferase
DW350_RS08630	COG1131	(ABC) transporter
DW350_RS08640	COG0471	metal ion transport
DW350_RS08655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DW350_RS08660	COG0574	Belongs to the PEP-utilizing enzyme family
DW350_RS08660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DW350_RS08685	COG0277	FAD linked oxidase domain protein
DW350_RS08685	COG0247	lactate metabolic process
DW350_RS08720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DW350_RS08735	COG2850	peptidyl-arginine hydroxylation
DW350_RS08740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DW350_RS08745	COG2915	High frequency lysogenization protein hflD homolog
DW350_RS08750	COG0482	sulfurtransferase activity
DW350_RS08760	COG1187	pseudouridine synthase activity
DW350_RS08770	COG1278	Cold shock
DW350_RS08775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DW350_RS08780	COG0542	response to heat
DW350_RS08785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DW350_RS08790	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DW350_RS08795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DW350_RS08800	COG0492	ferredoxin-NADP+ reductase activity
DW350_RS08805	COG0686	Belongs to the AlaDH PNT family
DW350_RS08815	COG1674	ftsk spoiiie
DW350_RS08815	COG0531	amino acid
DW350_RS08820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DW350_RS08825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DW350_RS08830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DW350_RS08855	COG2801	Transposase and inactivated derivatives
DW350_RS08860	COG2801	Transposase and inactivated derivatives
DW350_RS08895	COG0513	Belongs to the DEAD box helicase family
DW350_RS08920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DW350_RS08935	COG1278	Cold shock
DW350_RS08950	COG4206	TonB-dependent receptor
DW350_RS08960	COG1595	DNA-templated transcription, initiation
DW350_RS08965	COG2920	part of a sulfur-relay system
DW350_RS08975	COG2923	Belongs to the DsrF TusC family
DW350_RS08985	COG0670	Belongs to the BI1 family
DW350_RS08995	COG3781	membrane
DW350_RS09000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DW350_RS09005	COG0521	Mo-molybdopterin cofactor biosynthetic process
DW350_RS09010	COG0243	molybdopterin cofactor binding
DW350_RS09015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DW350_RS09020	COG0314	molybdopterin synthase activity
DW350_RS09025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DW350_RS09030	COG0315	cyclic pyranopterin monophosphate synthase activity
DW350_RS09035	COG0521	Mo-molybdopterin cofactor biosynthetic process
DW350_RS09040	COG0746	molybdenum cofactor guanylyltransferase activity
DW350_RS09045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DW350_RS09070	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DW350_RS09075	COG2197	response regulator
DW350_RS09080	COG0322	excinuclease ABC activity
DW350_RS09120	COG0640	Transcriptional regulator
DW350_RS09130	COG0431	NADPH-dependent FMN reductase
DW350_RS09135	COG0798	PFAM Bile acid sodium symporter
DW350_RS09140	COG0427	acetyl-CoA hydrolase
DW350_RS09145	COG1607	acyl-coa hydrolase
DW350_RS09155	COG2329	Antibiotic biosynthesis monooxygenase
DW350_RS09160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW350_RS09160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW350_RS09165	COG0489	protein tyrosine kinase activity
DW350_RS09170	COG0572	uridine kinase
DW350_RS09175	COG0717	Belongs to the dCTP deaminase family
DW350_RS09195	COG3118	belongs to the thioredoxin family
DW350_RS09200	COG4990	cell redox homeostasis
DW350_RS09200	COG3591	Belongs to the peptidase S1B family
DW350_RS09235	COG3082	Protein of unknown function (DUF1414)
DW350_RS09240	COG3081	Nucleoid-associated protein
DW350_RS09255	COG1704	LemA family
DW350_RS09260	COG0017	Asparaginyl-tRNA synthetase
DW350_RS09290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DW350_RS09295	COG0156	8-amino-7-oxononanoate synthase activity
DW350_RS09300	COG1073	alpha beta
DW350_RS09300	COG2226	methyltransferase
DW350_RS09310	COG1011	Hydrolase
DW350_RS09315	COG2207	Transcriptional regulator
DW350_RS09325	COG0791	NLP P60 protein
DW350_RS09335	COG0545	Peptidyl-prolyl cis-trans isomerase
DW350_RS09340	COG3340	Belongs to the peptidase S51 family
DW350_RS09345	COG0501	Belongs to the peptidase M48B family
DW350_RS09365	COG1061	Type III restriction enzyme res subunit
DW350_RS09375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DW350_RS09380	COG1530	ribonuclease E activity
DW350_RS09385	COG0564	pseudouridine synthase activity
DW350_RS09390	COG0546	phosphoglycolate phosphatase activity
DW350_RS09395	COG0424	maF-like protein
DW350_RS09400	COG1399	metal-binding, possibly nucleic acid-binding protein
DW350_RS09410	COG0416	fatty acid biosynthetic process
DW350_RS09415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DW350_RS09420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DW350_RS09430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DW350_RS09435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DW350_RS09440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DW350_RS09445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DW350_RS09450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DW350_RS09460	COG0084	hydrolase, TatD family'
DW350_RS09475	COG3008	intermembrane lipid transfer
DW350_RS09480	COG2995	paraquat-inducible protein a
DW350_RS09485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DW350_RS09490	COG0372	Belongs to the citrate synthase family
DW350_RS09495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DW350_RS09500	COG2828	Protein conserved in bacteria
DW350_RS09505	COG3141	response to X-ray
DW350_RS09515	COG1956	GAF domain-containing protein
DW350_RS09520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DW350_RS09525	COG0793	Belongs to the peptidase S41A family
DW350_RS09530	COG0733	neurotransmitter:sodium symporter activity
DW350_RS09535	COG1757	Na H antiporter
DW350_RS09540	COG0308	aminopeptidase N
DW350_RS09550	COG2902	Dehydrogenase
DW350_RS09555	COG0167	dihydroorotate dehydrogenase activity
DW350_RS09570	COG0488	(ABC) transporter
DW350_RS09580	COG3130	regulation of translation
DW350_RS09585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DW350_RS09590	COG1067	ATP-dependent peptidase activity
DW350_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS09605	COG2207	Transcriptional regulator
DW350_RS09610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DW350_RS09655	COG3047	cAMP biosynthetic process
DW350_RS09665	COG0037	tRNA processing
DW350_RS09680	COG1054	Belongs to the UPF0176 family
DW350_RS09685	COG1280	lysine exporter protein (LysE YggA)
DW350_RS09690	COG3842	ATPase activity
DW350_RS09695	COG1176	ABC-type spermidine putrescine transport system, permease component I
DW350_RS09700	COG1177	transmembrane transport
DW350_RS09710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DW350_RS09720	COG2205	protein histidine kinase activity
DW350_RS09720	COG2198	Histidine kinase
DW350_RS09720	COG0784	Response regulator, receiver
DW350_RS09725	COG3162	membrane
DW350_RS09730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DW350_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS09770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DW350_RS09775	COG0109	protoheme IX farnesyltransferase activity
DW350_RS09780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DW350_RS09785	COG1845	cytochrome c oxidase, subunit III
DW350_RS09795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DW350_RS09800	COG2358	TRAP transporter, solute receptor (TAXI family
DW350_RS09810	COG1119	ATPase activity
DW350_RS09820	COG0287	Prephenate dehydrogenase
DW350_RS09820	COG1605	Chorismate mutase
DW350_RS09840	COG2925	Exonuclease
DW350_RS09850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DW350_RS09860	COG1285	pathogenesis
DW350_RS09865	COG0840	transmembrane signaling receptor activity
DW350_RS09905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DW350_RS09920	COG4221	oxidoreductase activity
DW350_RS09930	COG0415	Belongs to the DNA photolyase family
DW350_RS09935	COG0789	Transcriptional regulator
DW350_RS09940	COG3272	Protein of unknown function (DUF1722)
DW350_RS09950	COG0776	regulation of translation
DW350_RS09955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW350_RS09955	COG0072	phenylalanine-tRNA ligase activity
DW350_RS09965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DW350_RS09970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DW350_RS09980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DW350_RS09995	COG3001	Fructosamine kinase
DW350_RS10010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DW350_RS10015	COG1187	pseudouridine synthase activity
DW350_RS10020	COG1448	Aminotransferase
DW350_RS10025	COG0824	Thioesterase
DW350_RS10040	COG1555	photosystem II stabilization
DW350_RS10045	COG0284	orotidine-5'-phosphate decarboxylase activity
DW350_RS10050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DW350_RS10060	COG0776	regulation of translation
DW350_RS10065	COG0539	negative regulation of cytoplasmic translation
DW350_RS10070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DW350_RS10075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DW350_RS10080	COG1605	Chorismate mutase
DW350_RS10080	COG0287	Prephenate dehydrogenase
DW350_RS10085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DW350_RS10095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DW350_RS10100	COG0546	phosphoglycolate phosphatase activity
DW350_RS10105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DW350_RS10130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW350_RS10135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DW350_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS10150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DW350_RS10175	COG2986	histidine ammonia-lyase
DW350_RS10185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DW350_RS10200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DW350_RS10205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DW350_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS10230	COG0302	gtp cyclohydrolase
DW350_RS10235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DW350_RS10245	COG0415	Belongs to the DNA photolyase family
DW350_RS10250	COG1595	DNA-templated transcription, initiation
DW350_RS10265	COG0733	neurotransmitter:sodium symporter activity
DW350_RS10275	COG1668	transmembrane transport
DW350_RS10280	COG4555	ABC transporter
DW350_RS10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS10295	COG1136	(ABC) transporter
DW350_RS10300	COG0577	efflux transmembrane transporter activity
DW350_RS10305	COG0800	Aldolase
DW350_RS10310	COG0129	dihydroxy-acid dehydratase activity
DW350_RS10315	COG0363	glucosamine-6-phosphate deaminase activity
DW350_RS10320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DW350_RS10325	COG1737	Transcriptional regulator
DW350_RS10330	COG0469	pyruvate kinase activity
DW350_RS10335	COG0697	spore germination
DW350_RS10340	COG3279	Response regulator of the LytR AlgR family
DW350_RS10345	COG3275	phosphorelay sensor kinase activity
DW350_RS10355	COG3201	nicotinamide mononucleotide transporter
DW350_RS10365	COG4771	TonB-dependent receptor
DW350_RS10370	COG0537	adenosine 5'-monophosphoramidase activity
DW350_RS10385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DW350_RS10405	COG2116	formate transmembrane transporter activity
DW350_RS10410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DW350_RS10420	COG4206	TonB-dependent receptor
DW350_RS10430	COG3273	potassium ion transport
DW350_RS10430	COG0471	metal ion transport
DW350_RS10450	COG0583	DNA-binding transcription factor activity
DW350_RS10510	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DW350_RS10535	COG1294	oxidase, subunit
DW350_RS10540	COG1271	oxidase subunit
DW350_RS10545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW350_RS10550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DW350_RS10555	COG3119	arylsulfatase activity
DW350_RS10565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW350_RS10625	COG2207	Transcriptional regulator
DW350_RS10660	COG2814	Major facilitator Superfamily
DW350_RS10665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DW350_RS10670	COG2610	gluconate transmembrane transporter activity
DW350_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS10680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DW350_RS10690	COG0616	signal peptide processing
DW350_RS10695	COG2267	carboxylic ester hydrolase activity
DW350_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS10705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW350_RS10710	COG2814	Major facilitator Superfamily
DW350_RS10715	COG1946	Acyl-CoA thioesterase
DW350_RS10720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DW350_RS10730	COG5001	Diguanylate cyclase
DW350_RS10730	COG4251	negative regulation of phosphorylation
DW350_RS10730	COG3706	GGDEF domain
DW350_RS10730	COG2203	Gaf domain
DW350_RS10745	COG0508	dehydrogenase complex catalyzes the overall conversion of
DW350_RS10750	COG0567	Dehydrogenase, E1 component
DW350_RS10755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DW350_RS10760	COG1053	succinate dehydrogenase
DW350_RS10765	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DW350_RS10770	COG2009	succinate dehydrogenase
DW350_RS10815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DW350_RS10820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DW350_RS10825	COG0840	transmembrane signaling receptor activity
DW350_RS10835	COG0835	chemotaxis
DW350_RS10840	COG0643	Histidine kinase
DW350_RS10840	COG2198	Histidine kinase
DW350_RS10845	COG0745	RESPONSE REGULATOR receiver
DW350_RS10860	COG3135	benzoate transporter
DW350_RS10865	COG1396	sequence-specific DNA binding
DW350_RS10870	COG3507	Belongs to the glycosyl hydrolase 43 family
DW350_RS10880	COG2835	tetraacyldisaccharide 4'-kinase activity
DW350_RS10885	COG1663	tetraacyldisaccharide 4'-kinase activity
DW350_RS10890	COG1132	(ABC) transporter
DW350_RS10895	COG0658	competence protein
DW350_RS10895	COG2333	competence protein COMEC
DW350_RS10905	COG4591	ABC-type transport system involved in lipoprotein release permease component
DW350_RS10910	COG1136	(ABC) transporter
DW350_RS10915	COG4591	ABC-type transport system involved in lipoprotein release permease component
DW350_RS10935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DW350_RS10945	COG1879	ABC-type sugar transport system periplasmic component
DW350_RS10955	COG1472	Belongs to the glycosyl hydrolase 3 family
DW350_RS10960	COG1960	acyl-CoA dehydrogenase activity
DW350_RS10985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DW350_RS10995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DW350_RS11005	COG1966	Carbon starvation protein
DW350_RS11010	COG3279	Response regulator of the LytR AlgR family
DW350_RS11015	COG3275	phosphorelay sensor kinase activity
DW350_RS11050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DW350_RS11125	COG2824	Alkylphosphonate utilization operon protein PhnA
DW350_RS11135	COG0583	DNA-binding transcription factor activity
DW350_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS11160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DW350_RS11180	COG3123	guanosine phosphorylase activity
DW350_RS11190	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS11195	COG1454	alcohol dehydrogenase
DW350_RS11200	COG0477	Major facilitator Superfamily
DW350_RS11205	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DW350_RS11235	COG0402	S-adenosylhomocysteine deaminase activity
DW350_RS11245	COG1902	pentaerythritol trinitrate reductase activity
DW350_RS11370	COG0583	DNA-binding transcription factor activity
DW350_RS11390	COG0823	Involved in the tonB-independent uptake of proteins
DW350_RS11390	COG1506	peptidase
DW350_RS11410	COG1760	l-serine dehydratase
DW350_RS11415	COG3002	Belongs to the UPF0753 family
DW350_RS11425	COG0583	DNA-binding transcription factor activity
DW350_RS11435	COG4628	conserved protein (DUF2132)
DW350_RS11455	COG2095	MarC family integral membrane protein
DW350_RS11460	COG4948	Mandelate Racemase Muconate Lactonizing
DW350_RS11470	COG0471	metal ion transport
DW350_RS11475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DW350_RS11480	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DW350_RS11505	COG3724	N-succinylarginine dihydrolase activity
DW350_RS11510	COG1301	dicarboxylic acid transport
DW350_RS11520	COG0647	UMP catabolic process
DW350_RS11530	COG0386	Belongs to the glutathione peroxidase family
DW350_RS11535	COG4651	solute:proton antiporter activity
DW350_RS11535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DW350_RS11545	COG0668	transmembrane transport
DW350_RS11550	COG2860	membrane
DW350_RS11560	COG1104	cysteine desulfurase activity
DW350_RS11575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DW350_RS11600	COG1970	mechanosensitive ion channel activity
DW350_RS11605	COG0351	phosphomethylpyrimidine kinase
DW350_RS11610	COG2226	methyltransferase
DW350_RS11615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DW350_RS11640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DW350_RS11645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DW350_RS11650	COG0009	L-threonylcarbamoyladenylate synthase
DW350_RS11655	COG0613	PHP domain protein
DW350_RS11660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DW350_RS11665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DW350_RS11670	COG0512	Glutamine amidotransferase of anthranilate synthase
DW350_RS11675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DW350_RS11680	COG0134	indole-3-glycerol-phosphate synthase activity
DW350_RS11680	COG0135	phosphoribosylanthranilate isomerase activity
DW350_RS11685	COG0133	tryptophan synthase activity
DW350_RS11690	COG0159	tryptophan synthase activity
DW350_RS11695	COG3530	Putative quorum-sensing-regulated virulence factor
DW350_RS11700	COG1278	Cold shock
DW350_RS11710	COG0189	ligase activity
DW350_RS11710	COG0569	domain protein
DW350_RS11725	COG2350	Protein conserved in bacteria
DW350_RS11730	COG2084	Dehydrogenase
DW350_RS11735	COG1380	Effector of murein hydrolase LrgA
DW350_RS11740	COG1346	cytolysis
DW350_RS11745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DW350_RS11760	COG0149	triose-phosphate isomerase activity
DW350_RS11775	COG2885	chlorophyll binding
DW350_RS11775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DW350_RS11790	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DW350_RS11795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DW350_RS11800	COG2095	MarC family integral membrane protein
DW350_RS11810	COG2031	fatty acid transporter
DW350_RS11815	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DW350_RS11820	COG0259	pyridoxamine-phosphate oxidase activity
DW350_RS11850	COG0251	oxidation-reduction process
DW350_RS11855	COG0708	Exodeoxyribonuclease III
DW350_RS11885	COG0280	phosphate acetyltransferase
DW350_RS11885	COG0857	belongs to the CobB CobQ family
DW350_RS11890	COG1752	Esterase of the alpha-beta hydrolase superfamily
DW350_RS11905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DW350_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS11920	COG1024	Enoyl-CoA hydratase
DW350_RS11920	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW350_RS11925	COG1024	Enoyl-CoA hydratase
DW350_RS11940	COG0183	Belongs to the thiolase family
DW350_RS11950	COG1960	acyl-CoA dehydrogenase activity
DW350_RS11955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DW350_RS11975	COG5001	Diguanylate cyclase
DW350_RS12015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DW350_RS12020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DW350_RS12030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DW350_RS12035	COG0071	Belongs to the small heat shock protein (HSP20) family
DW350_RS12045	COG1643	Atp-dependent helicase
DW350_RS12050	COG0517	IMP dehydrogenase activity
DW350_RS12055	COG3228	Belongs to the MtfA family
DW350_RS12075	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DW350_RS12090	COG0587	DNA-directed DNA polymerase activity
DW350_RS12095	COG4771	TonB-dependent receptor
DW350_RS12110	COG1309	transcriptional regulator
DW350_RS12115	COG0300	oxidoreductase activity
DW350_RS12125	COG2814	Major facilitator Superfamily
DW350_RS12130	COG2723	6-phospho-beta-galactosidase activity
DW350_RS12155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DW350_RS12180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DW350_RS12185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DW350_RS12190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DW350_RS12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DW350_RS12200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DW350_RS12200	COG0662	Cupin 2, conserved barrel domain protein
DW350_RS12220	COG1215	transferase activity, transferring glycosyl groups
DW350_RS12225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW350_RS12235	COG0859	PFAM glycosyl transferase family 9
DW350_RS12250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW350_RS12265	COG3206	protein involved in exopolysaccharide biosynthesis
DW350_RS12265	COG0489	protein tyrosine kinase activity
DW350_RS12280	COG3104	oligopeptide transport
DW350_RS12285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DW350_RS12295	COG0745	RESPONSE REGULATOR receiver
DW350_RS12300	COG2853	Lipoprotein
DW350_RS12315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DW350_RS12320	COG1138	Cytochrome C-type biogenesis protein
DW350_RS12325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DW350_RS12335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DW350_RS12340	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DW350_RS12365	COG0835	chemotaxis
DW350_RS12375	COG1192	Involved in chromosome partitioning
DW350_RS12380	COG1360	Flagellar Motor Protein
DW350_RS12385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DW350_RS12390	COG2201	protein-glutamate methylesterase activity
DW350_RS12395	COG0784	Response regulator, receiver
DW350_RS12395	COG0643	Histidine kinase
DW350_RS12395	COG2198	Histidine kinase
DW350_RS12400	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DW350_RS12435	COG1684	flagellar biosynthetic protein fliR
DW350_RS12440	COG1987	bacterial-type flagellum assembly
DW350_RS12490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DW350_RS12500	COG1677	Flagellar hook-basal body complex protein FliE
DW350_RS12525	COG1086	Polysaccharide biosynthesis protein
DW350_RS12530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DW350_RS12535	COG1083	cytidylyl-transferase
DW350_RS12545	COG2089	acid synthase
DW350_RS12585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DW350_RS12590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DW350_RS12600	COG1256	bacterial-type flagellum assembly
DW350_RS12605	COG1705	Flagellar rod assembly protein muramidase FlgJ
DW350_RS12605	COG3951	Flagellar rod assembly protein muramidase FlgJ
DW350_RS12610	COG1706	bacterial-type flagellum-dependent cell motility
DW350_RS12620	COG4787	bacterial-type flagellum-dependent cell motility
DW350_RS12640	COG1815	bacterial-type flagellum-dependent cell motility
DW350_RS12645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DW350_RS12650	COG0784	Response regulator, receiver
DW350_RS12650	COG0835	chemotaxis
DW350_RS12655	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
DW350_RS12715	COG5520	Belongs to the glycosyl hydrolase 30 family
DW350_RS12715	COG3291	Pkd domain containing protein
DW350_RS12715	COG4447	cellulose binding
DW350_RS12735	COG2267	carboxylic ester hydrolase activity
DW350_RS12755	COG2311	Membrane
DW350_RS12780	COG4890	Cyd operon protein YbgT
DW350_RS12785	COG1294	oxidase, subunit
DW350_RS12805	COG1902	pentaerythritol trinitrate reductase activity
DW350_RS12815	COG4175	Glycine betaine
DW350_RS12815	COG0517	IMP dehydrogenase activity
DW350_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS12845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DW350_RS12855	COG0066	3-isopropylmalate dehydratase activity
DW350_RS12860	COG0473	3-isopropylmalate dehydrogenase activity
DW350_RS12880	COG2801	Transposase and inactivated derivatives
DW350_RS12905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DW350_RS12910	COG0193	aminoacyl-tRNA hydrolase activity
DW350_RS12915	COG0012	GTP binding
DW350_RS12940	COG4773	Receptor
DW350_RS12950	COG3243	poly(R)-hydroxyalkanoic acid synthase
DW350_RS12955	COG0280	phosphate acetyltransferase
DW350_RS12960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DW350_RS12965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DW350_RS12970	COG2818	Glycosylase
DW350_RS12985	COG0163	prenyltransferase activity
DW350_RS12990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DW350_RS13015	COG0583	DNA-binding transcription factor activity
DW350_RS13025	COG0840	transmembrane signaling receptor activity
DW350_RS13030	COG0246	Mannitol dehydrogenase
DW350_RS13035	COG1904	glucuronate isomerase
DW350_RS13075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW350_RS13090	COG1702	phosphate starvation-inducible protein PhoH
DW350_RS13095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DW350_RS13105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DW350_RS13120	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DW350_RS13125	COG1466	dna polymerase III delta subunit
DW350_RS13130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DW350_RS13135	COG0799	negative regulation of ribosome biogenesis
DW350_RS13140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DW350_RS13145	COG0768	penicillin binding
DW350_RS13150	COG0772	Belongs to the SEDS family
DW350_RS13155	COG2951	lytic endotransglycosylase activity
DW350_RS13160	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DW350_RS13165	COG1686	Belongs to the peptidase S11 family
DW350_RS13170	COG2921	Belongs to the UPF0250 family
DW350_RS13175	COG0321	lipoyl(octanoyl) transferase activity
DW350_RS13180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DW350_RS13195	COG0793	Belongs to the peptidase S41A family
DW350_RS13195	COG4946	Tricorn protease homolog
DW350_RS13200	COG5001	Diguanylate cyclase
DW350_RS13200	COG3300	MHYT domain
DW350_RS13210	COG1185	polyribonucleotide nucleotidyltransferase activity
DW350_RS13220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DW350_RS13225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DW350_RS13230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DW350_RS13235	COG0195	Participates in both transcription termination and antitermination
DW350_RS13240	COG0779	Required for maturation of 30S ribosomal subunits
DW350_RS13255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DW350_RS13260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DW350_RS13265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DW350_RS13270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DW350_RS13275	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DW350_RS13280	COG1534	Rna-binding protein
DW350_RS13295	COG2885	chlorophyll binding
DW350_RS13300	COG3243	poly(R)-hydroxyalkanoic acid synthase
DW350_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS13315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DW350_RS13320	COG0505	Belongs to the CarA family
DW350_RS13325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DW350_RS13330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DW350_RS13335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS13340	COG1757	Na H antiporter
DW350_RS13345	COG0583	DNA-binding transcription factor activity
DW350_RS13350	COG0667	Aldo Keto reductase
DW350_RS13355	COG2203	Gaf domain
DW350_RS13355	COG3706	GGDEF domain
DW350_RS13355	COG5001	Diguanylate cyclase
DW350_RS13355	COG4251	negative regulation of phosphorylation
DW350_RS13365	COG2378	regulation of single-species biofilm formation
DW350_RS13375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DW350_RS13385	COG0840	transmembrane signaling receptor activity
DW350_RS13395	COG2814	Major facilitator Superfamily
DW350_RS13405	COG0501	Belongs to the peptidase M48B family
DW350_RS13420	COG0484	heat shock protein binding
DW350_RS13430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DW350_RS13435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DW350_RS13440	COG0497	DNA recombination
DW350_RS13445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DW350_RS13450	COG2914	Belongs to the UPF0125 (RnfH) family
DW350_RS13455	COG2867	negative regulation of translational initiation
DW350_RS13470	COG1360	Flagellar Motor Protein
DW350_RS13475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DW350_RS13480	COG1191	sigma factor activity
DW350_RS13505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DW350_RS13510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DW350_RS13520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DW350_RS13525	COG1256	bacterial-type flagellum assembly
DW350_RS13525	COG4786	Flagellar basal body rod
DW350_RS13535	COG1706	bacterial-type flagellum-dependent cell motility
DW350_RS13540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DW350_RS13545	COG4786	Flagellar basal body rod
DW350_RS13550	COG4786	Flagellar basal body rod
DW350_RS13555	COG1749	Flagellar hook protein flgE
DW350_RS13565	COG1558	bacterial-type flagellum-dependent cell motility
DW350_RS13570	COG1815	bacterial-type flagellum-dependent cell motility
DW350_RS13575	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
DW350_RS13615	COG1677	Flagellar hook-basal body complex protein FliE
DW350_RS13635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DW350_RS13645	COG1987	bacterial-type flagellum assembly
DW350_RS13685	COG0668	transmembrane transport
DW350_RS13695	COG1376	ErfK ybiS ycfS ynhG family protein
DW350_RS13725	COG0523	cobalamin synthesis protein
DW350_RS13750	COG0745	RESPONSE REGULATOR receiver
DW350_RS13755	COG2205	protein histidine kinase activity
DW350_RS13775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DW350_RS13785	COG1942	4-Oxalocrotonate Tautomerase
DW350_RS13790	COG0667	Aldo Keto reductase
DW350_RS13805	COG0583	DNA-binding transcription factor activity
DW350_RS13810	COG2814	Major facilitator Superfamily
DW350_RS13825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DW350_RS13840	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DW350_RS13855	COG5002	protein histidine kinase activity
DW350_RS13855	COG5001	Diguanylate cyclase
DW350_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS13970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DW350_RS13985	COG1757	Na H antiporter
DW350_RS13990	COG1073	alpha beta
DW350_RS13995	COG0335	large ribosomal subunit rRNA binding
DW350_RS14000	COG0336	Belongs to the RNA methyltransferase TrmD family
DW350_RS14005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DW350_RS14010	COG0228	four-way junction DNA binding
DW350_RS14015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DW350_RS14020	COG4137	Cytochrome C assembly protein
DW350_RS14025	COG4536	flavin adenine dinucleotide binding
DW350_RS14035	COG0626	cystathionine gamma-synthase activity
DW350_RS14040	COG2918	glutathione biosynthetic process
DW350_RS14045	COG1301	dicarboxylic acid transport
DW350_RS14070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DW350_RS14095	COG1546	Belongs to the CinA family
DW350_RS14105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW350_RS14110	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS14115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DW350_RS14120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW350_RS14125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW350_RS14130	COG0174	glutamine synthetase
DW350_RS14135	COG0174	glutamine synthetase
DW350_RS14150	COG3842	ATPase activity
DW350_RS14155	COG1176	ABC-type spermidine putrescine transport system, permease component I
DW350_RS14160	COG1177	transmembrane transport
DW350_RS14170	COG1917	Cupin 2, conserved barrel domain protein
DW350_RS14170	COG1396	sequence-specific DNA binding
DW350_RS14175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DW350_RS14185	COG1238	metal cluster binding
DW350_RS14190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DW350_RS14195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DW350_RS14200	COG0585	pseudouridine synthase activity
DW350_RS14205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DW350_RS14210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DW350_RS14220	COG0625	glutathione transferase activity
DW350_RS14230	COG0148	phosphopyruvate hydratase activity
DW350_RS14235	COG0504	CTP synthase activity
DW350_RS14240	COG3956	TIGRFAM MazG family protein
DW350_RS14245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DW350_RS14250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DW350_RS14265	COG1968	undecaprenyl-diphosphatase activity
DW350_RS14280	COG0736	holo-[acyl-carrier-protein] synthase activity
DW350_RS14285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DW350_RS14290	COG1381	Involved in DNA repair and RecF pathway recombination
DW350_RS14300	COG0571	ribonuclease III activity
DW350_RS14315	COG0481	GTPase activity
DW350_RS14320	COG3086	response to oxidative stress
DW350_RS14325	COG3026	antisigma factor binding
DW350_RS14335	COG1595	DNA-templated transcription, initiation
DW350_RS14340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DW350_RS14350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DW350_RS14365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DW350_RS14375	COG1252	NADH dehydrogenase
DW350_RS14380	COG5001	Diguanylate cyclase
DW350_RS14380	COG3300	MHYT domain
DW350_RS14405	COG0488	(ABC) transporter
DW350_RS14415	COG1725	Transcriptional regulator
DW350_RS14420	COG1131	(ABC) transporter
DW350_RS14440	COG0417	DNA replication proofreading
DW350_RS14445	COG0693	protein deglycase activity
DW350_RS14450	COG0840	transmembrane signaling receptor activity
DW350_RS14455	COG1131	(ABC) transporter
DW350_RS14470	COG2199	diguanylate cyclase activity
DW350_RS14470	COG2200	EAL domain
DW350_RS14510	COG3618	amidohydrolase
DW350_RS14520	COG3706	GGDEF domain
DW350_RS14560	COG2801	Transposase and inactivated derivatives
DW350_RS14565	COG2801	Transposase and inactivated derivatives
DW350_RS14595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DW350_RS14610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DW350_RS14620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DW350_RS14625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DW350_RS14630	COG4974	Belongs to the 'phage' integrase family
DW350_RS14635	COG0716	FMN binding
DW350_RS14650	COG0513	Belongs to the DEAD box helicase family
DW350_RS14655	COG0727	PFAM Uncharacterised protein family (UPF0153)
DW350_RS14685	COG3022	response to hydroperoxide
DW350_RS14690	COG1115	amino acid carrier protein
DW350_RS14695	COG2974	May be involved in recombination
DW350_RS14705	COG0826	peptidase U32
DW350_RS14710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DW350_RS14725	COG0840	transmembrane signaling receptor activity
DW350_RS14740	COG2252	PERMEase
DW350_RS14745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DW350_RS14750	COG0581	inorganic phosphate transmembrane transporter activity
DW350_RS14755	COG0573	inorganic phosphate transmembrane transporter activity
DW350_RS14765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW350_RS14785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DW350_RS14790	COG0427	acetyl-CoA hydrolase
DW350_RS14795	COG3248	Nucleoside-binding outer membrane protein
DW350_RS14820	COG2199	diguanylate cyclase activity
DW350_RS14825	COG0625	glutathione transferase activity
DW350_RS14830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DW350_RS14835	COG2166	iron-sulfur cluster assembly
DW350_RS14840	COG0697	spore germination
DW350_RS14845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DW350_RS14875	COG0745	RESPONSE REGULATOR receiver
DW350_RS14880	COG5002	protein histidine kinase activity
DW350_RS14880	COG2198	Histidine kinase
DW350_RS14880	COG0784	Response regulator, receiver
DW350_RS14885	COG0070	glutamate synthase
DW350_RS14885	COG0067	glutamate synthase
DW350_RS14885	COG0069	glutamate synthase activity
DW350_RS14890	COG0493	'glutamate synthase
DW350_RS14895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DW350_RS14925	COG1215	transferase activity, transferring glycosyl groups
DW350_RS14930	COG0366	Alpha amylase catalytic
DW350_RS14935	COG2943	transferase activity, transferring hexosyl groups
DW350_RS14940	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DW350_RS14945	COG0590	tRNA wobble adenosine to inosine editing
DW350_RS14955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DW350_RS14960	COG0739	heme binding
DW350_RS14965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DW350_RS14985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DW350_RS14995	COG2610	gluconate transmembrane transporter activity
DW350_RS15000	COG3021	interspecies interaction between organisms
DW350_RS15010	COG3023	N-Acetylmuramoyl-L-alanine amidase
DW350_RS15035	COG0316	Belongs to the HesB IscA family
DW350_RS15045	COG0540	Belongs to the ATCase OTCase family
DW350_RS15050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DW350_RS15060	COG5001	Diguanylate cyclase
DW350_RS15060	COG3300	MHYT domain
DW350_RS15070	COG1846	Transcriptional regulator
DW350_RS15075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DW350_RS15080	COG2031	fatty acid transporter
DW350_RS15090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DW350_RS15095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DW350_RS15100	COG1414	Transcriptional regulator
DW350_RS15105	COG1643	Atp-dependent helicase
DW350_RS15120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW350_RS15125	COG1489	DNA binding
DW350_RS15130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DW350_RS15135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DW350_RS15140	COG0617	tRNA 3'-terminal CCA addition
DW350_RS15145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DW350_RS15155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DW350_RS15160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DW350_RS15165	COG4106	trans-aconitate 2-methyltransferase activity
DW350_RS15170	COG0842	Transport permease protein
DW350_RS15175	COG1131	(ABC) transporter
DW350_RS15185	COG0288	reversible hydration of carbon dioxide
DW350_RS15190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DW350_RS15195	COG0163	prenyltransferase activity
DW350_RS15200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DW350_RS15205	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DW350_RS15210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DW350_RS15225	COG0754	glutathionylspermidine amidase activity
DW350_RS15235	COG3766	membrane
DW350_RS15240	COG0633	Ferredoxin
DW350_RS15250	COG0006	proline dipeptidase activity
DW350_RS15250	COG0006	proline dipeptidase activity
DW350_RS15260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DW350_RS15265	COG3108	Peptidase M15
DW350_RS15270	COG2989	Protein conserved in bacteria
DW350_RS15285	COG0529	Catalyzes the synthesis of activated sulfate
DW350_RS15290	COG2895	sulfate adenylyltransferase (ATP) activity
DW350_RS15300	COG1648	precorrin-2 dehydrogenase activity
DW350_RS15300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DW350_RS15305	COG0175	sulfate reduction
DW350_RS15310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DW350_RS15315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DW350_RS15355	COG1024	Enoyl-CoA hydratase
DW350_RS15375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DW350_RS15380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DW350_RS15500	COG0583	DNA-binding transcription factor activity
DW350_RS15525	COG4249	Peptidase C14 caspase catalytic subunit p20
DW350_RS15525	COG2319	Wd-40 repeat
DW350_RS15555	COG1902	pentaerythritol trinitrate reductase activity
DW350_RS15560	COG0656	L-ascorbic acid biosynthetic process
DW350_RS15565	COG0583	DNA-binding transcription factor activity
DW350_RS15585	COG0444	Belongs to the ABC transporter superfamily
DW350_RS15590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DW350_RS15595	COG0601	transmembrane transport
DW350_RS15600	COG4166	transmembrane transport
DW350_RS15615	COG5001	Diguanylate cyclase
DW350_RS15615	COG4251	negative regulation of phosphorylation
DW350_RS15615	COG2203	Gaf domain
DW350_RS15615	COG3706	GGDEF domain
DW350_RS15620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DW350_RS15640	COG1733	regulation of RNA biosynthetic process
DW350_RS15645	COG0432	Pfam Uncharacterised protein family UPF0047
DW350_RS15655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DW350_RS15660	COG0305	Participates in initiation and elongation during chromosome replication
DW350_RS15680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DW350_RS15700	COG3209	COG3209 Rhs family protein
DW350_RS15770	COG0631	protein serine/threonine phosphatase activity
DW350_RS15805	COG2815	serine threonine protein kinase
DW350_RS15805	COG0515	serine threonine protein kinase
DW350_RS15815	COG0138	bifunctional purine biosynthesis protein purh
DW350_RS15820	COG0151	Belongs to the GarS family
DW350_RS15840	COG4302	ethanolamine ammonia-lyase activity
DW350_RS15845	COG4303	Ethanolamine ammonia lyase large subunit
DW350_RS15855	COG0217	transcriptional regulatory protein
DW350_RS15860	COG5380	lipid catabolic process
DW350_RS15865	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DW350_RS15875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DW350_RS15880	COG1074	ATP-dependent DNA helicase activity
DW350_RS15925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DW350_RS15935	COG3493	citrate carrier protein
DW350_RS15955	COG1451	nucleotide metabolic process
DW350_RS15990	COG0513	Belongs to the DEAD box helicase family
DW350_RS15995	COG0513	Belongs to the DEAD box helicase family
DW350_RS16005	COG0419	ATPase involved in DNA repair
DW350_RS16010	COG0420	3'-5' exonuclease activity
DW350_RS16015	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DW350_RS16050	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DW350_RS16055	COG0583	DNA-binding transcription factor activity
DW350_RS16060	COG2356	endonuclease I
DW350_RS16065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DW350_RS16070	COG0189	ligase activity
DW350_RS16075	COG1678	Uncharacterized ACR, COG1678
DW350_RS16080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DW350_RS16095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DW350_RS16100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DW350_RS16105	COG0762	integral membrane protein
DW350_RS16110	COG1872	DUF167
DW350_RS16120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DW350_RS16140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DW350_RS16145	COG1194	a g-specific adenine glycosylase
DW350_RS16150	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DW350_RS16175	COG2971	BadF BadG BcrA BcrD
DW350_RS16185	COG2813	Specifically methylates the guanine in position
DW350_RS16205	COG3313	Fe-S protein
DW350_RS16210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DW350_RS16225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DW350_RS16230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DW350_RS16240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DW350_RS16245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DW350_RS16250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DW350_RS16255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DW350_RS16260	COG2967	ApaG domain
DW350_RS16265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DW350_RS16300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DW350_RS16305	COG0142	geranyltranstransferase activity
DW350_RS16320	COG1438	arginine binding
DW350_RS16325	COG0004	ammonium transporteR
DW350_RS16345	COG1049	propionate catabolic process, 2-methylcitrate cycle
DW350_RS16355	COG3590	peptidase
DW350_RS16365	COG2990	Protein conserved in bacteria
DW350_RS16370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DW350_RS16375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DW350_RS16380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DW350_RS16385	COG0508	dehydrogenase complex catalyzes the overall conversion of
DW350_RS16390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DW350_RS16395	COG2186	Transcriptional regulator
DW350_RS16415	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DW350_RS16420	COG0237	dephospho-CoA kinase activity
DW350_RS16430	COG1459	type II secretion system
DW350_RS16435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DW350_RS16440	COG4969	Belongs to the N-Me-Phe pilin family
DW350_RS16450	COG0589	response to stress
DW350_RS16455	COG0659	secondary active sulfate transmembrane transporter activity
DW350_RS16460	COG3038	cytochrome b561
DW350_RS16465	COG3118	belongs to the thioredoxin family
DW350_RS16470	COG0494	nUDIX hydrolase
DW350_RS16485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DW350_RS16490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DW350_RS16495	COG0849	cell division
DW350_RS16500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DW350_RS16505	COG1181	Belongs to the D-alanine--D-alanine ligase family
DW350_RS16510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DW350_RS16515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DW350_RS16520	COG0772	Belongs to the SEDS family
DW350_RS16525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DW350_RS16530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DW350_RS16535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DW350_RS16545	COG0768	penicillin binding
DW350_RS16550	COG3116	cell division
DW350_RS16555	COG0275	rRNA processing
DW350_RS16560	COG2001	Belongs to the MraZ family
DW350_RS16570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DW350_RS16575	COG3107	peptidoglycan biosynthetic process
DW350_RS16580	COG0792	nuclease activity
DW350_RS16585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DW350_RS16590	COG2823	Periplasmic or secreted lipoprotein
DW350_RS16595	COG2969	positive regulation of protein catabolic process
DW350_RS16600	COG0625	glutathione transferase activity
DW350_RS16605	COG2857	Cytochrome c1
DW350_RS16610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DW350_RS16615	COG0723	plastoquinol--plastocyanin reductase activity
DW350_RS16625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DW350_RS16630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DW350_RS16640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DW350_RS16650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DW350_RS16655	COG5007	Belongs to the BolA IbaG family
DW350_RS16665	COG2854	intermembrane phospholipid transfer
DW350_RS16670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DW350_RS16675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DW350_RS16680	COG1127	ABC transporter
DW350_RS16685	COG0517	IMP dehydrogenase activity
DW350_RS16685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DW350_RS16690	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DW350_RS16705	COG1137	ATPase activity
DW350_RS16710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DW350_RS16720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DW350_RS16725	COG1660	Displays ATPase and GTPase activities
DW350_RS16730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DW350_RS16735	COG2239	Acts as a magnesium transporter
DW350_RS16740	COG0312	modulator of DNA gyrase
DW350_RS16745	COG3028	Belongs to the UPF0307 family
DW350_RS16760	COG0577	efflux transmembrane transporter activity
DW350_RS16760	COG1136	(ABC) transporter
DW350_RS16775	COG0312	modulator of DNA gyrase
DW350_RS16780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DW350_RS16785	COG3164	Protein of unknown function
DW350_RS16790	COG1530	ribonuclease E activity
DW350_RS16795	COG0424	maF-like protein
DW350_RS16800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DW350_RS16805	COG1792	Involved in formation and maintenance of cell shape
DW350_RS16810	COG1077	Cell shape determining protein MreB Mrl
DW350_RS16840	COG2165	general secretion pathway protein
DW350_RS16845	COG2165	general secretion pathway protein
DW350_RS16855	COG1459	type II secretion system
DW350_RS16860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DW350_RS16870	COG3409	Peptidoglycan-binding domain 1 protein
DW350_RS16870	COG3267	Type II secretory pathway component ExeA
DW350_RS16905	COG2200	EAL domain
DW350_RS16905	COG2199	diguanylate cyclase activity
DW350_RS16910	COG0583	DNA-binding transcription factor activity
DW350_RS16915	COG1566	PFAM secretion protein HlyD family protein
DW350_RS16945	COG2814	Major facilitator Superfamily
DW350_RS16950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DW350_RS16980	COG0531	amino acid
DW350_RS16985	COG1522	sequence-specific DNA binding
DW350_RS17035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DW350_RS17040	COG4993	Dehydrogenase
DW350_RS17045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DW350_RS17050	COG0460	homoserine dehydrogenase
DW350_RS17050	COG0527	aspartate kinase activity
DW350_RS17055	COG0626	cystathionine gamma-synthase activity
DW350_RS17060	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
DW350_RS17075	COG0281	malic enzyme
DW350_RS17080	COG0254	rRNA binding
DW350_RS17085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DW350_RS17095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DW350_RS17100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DW350_RS17120	COG0583	DNA-binding transcription factor activity
DW350_RS17140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DW350_RS17150	COG3537	Alpha-1,2-mannosidase
DW350_RS17190	COG2132	Multicopper oxidase
DW350_RS17195	COG0745	RESPONSE REGULATOR receiver
DW350_RS17200	COG5002	protein histidine kinase activity
DW350_RS17210	COG4771	TonB-dependent receptor
DW350_RS17235	COG0251	oxidation-reduction process
DW350_RS17270	COG1012	belongs to the aldehyde dehydrogenase family
DW350_RS17285	COG2130	NADP-dependent
DW350_RS17290	COG1309	transcriptional regulator
DW350_RS17305	COG0583	DNA-binding transcription factor activity
DW350_RS17310	COG0746	molybdenum cofactor guanylyltransferase activity
DW350_RS17315	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DW350_RS17330	COG2080	2 iron, 2 sulfur cluster binding
DW350_RS17360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DW350_RS17370	COG2264	protein methyltransferase activity
DW350_RS17395	COG1297	OPT oligopeptide transporter protein
DW350_RS17400	COG0439	Biotin carboxylase
DW350_RS17405	COG0511	ligase activity, forming carbon-carbon bonds
DW350_RS17410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DW350_RS17415	COG1082	Xylose isomerase domain protein TIM barrel
DW350_RS17440	COG0457	Tetratricopeptide repeat
DW350_RS17450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DW350_RS17455	COG0583	DNA-binding transcription factor activity
DW350_RS17470	COG3423	Transcriptional regulator
DW350_RS17475	COG2801	Transposase and inactivated derivatives
DW350_RS17480	COG2842	Transposition protein
DW350_RS17530	COG4382	Mu-like prophage protein Gp16
DW350_RS17540	COG5566	PFAM Mor transcription activator
DW350_RS17575	COG0640	Transcriptional regulator
DW350_RS17590	COG4373	Mu-like prophage FluMu protein gp28
DW350_RS17595	COG4383	Mu-like prophage protein gp29
DW350_RS17630	COG4388	Caudovirus prohead serine protease
DW350_RS17635	COG4397	Mu-like prophage major head subunit gpT
DW350_RS17645	COG4387	Mu-like prophage protein GP36
DW350_RS17725	COG1280	lysine exporter protein (LysE YggA)
DW350_RS17750	COG2188	Transcriptional regulator
DW350_RS17755	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DW350_RS17770	COG0840	transmembrane signaling receptor activity
DW350_RS17775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DW350_RS17805	COG2801	Transposase and inactivated derivatives
DW350_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
DW350_RS17890	COG0583	DNA-binding transcription factor activity
DW350_RS17920	COG0583	DNA-binding transcription factor activity
DW350_RS17925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DW350_RS17950	COG0386	Belongs to the glutathione peroxidase family
DW350_RS17955	COG2211	Major facilitator Superfamily
DW350_RS17970	COG0386	Belongs to the glutathione peroxidase family
DW350_RS17975	COG4946	Tricorn protease homolog
DW350_RS17975	COG1506	peptidase
DW350_RS17975	COG0823	Involved in the tonB-independent uptake of proteins
DW350_RS17990	COG0657	acetylesterase activity
DW350_RS18000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DW350_RS18005	COG1733	regulation of RNA biosynthetic process
DW350_RS18010	COG0625	glutathione transferase activity
DW350_RS18045	COG2814	Major facilitator Superfamily
DW350_RS18050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DW350_RS18050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DW350_RS18085	COG3085	chromosome segregation
DW350_RS18090	COG0189	ligase activity
DW350_RS18100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW350_RS18105	COG1136	(ABC) transporter
DW350_RS18115	COG1136	(ABC) transporter
DW350_RS18115	COG0577	efflux transmembrane transporter activity
DW350_RS18120	COG2204	response regulator
DW350_RS18140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DW350_RS18145	COG2193	ferroxidase activity
DW350_RS18155	COG2226	methyltransferase
DW350_RS18160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DW350_RS18180	COG0514	ATP-dependent DNA helicase (RecQ)
DW350_RS18195	COG1741	Belongs to the pirin family
DW350_RS18200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DW350_RS18220	COG3706	GGDEF domain
DW350_RS18230	COG0671	phosphoesterase, PA-phosphatase related
DW350_RS18235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DW350_RS18240	COG2200	EAL domain
DW350_RS18250	COG5001	Diguanylate cyclase
DW350_RS18250	COG4251	negative regulation of phosphorylation
DW350_RS18250	COG3706	GGDEF domain
DW350_RS18250	COG2203	Gaf domain
DW350_RS18255	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DW350_RS18260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DW350_RS18260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DW350_RS18280	COG3078	GTPase activator activity
DW350_RS18295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DW350_RS18305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DW350_RS18315	COG1322	Protein conserved in bacteria
DW350_RS18330	COG2261	transglycosylase associated protein
DW350_RS18350	COG2095	MarC family integral membrane protein
DW350_RS18370	COG0742	ribosomal rna small subunit methyltransferase
DW350_RS18380	COG2884	Cell division ATP-binding protein ftsE
DW350_RS18385	COG2177	Part of the ABC transporter FtsEX involved in
DW350_RS18400	COG2861	carbohydrate metabolic process
DW350_RS18405	COG0793	Belongs to the peptidase S41A family
DW350_RS18410	COG4942	peptidase
DW350_RS18415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DW350_RS18425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DW350_RS18430	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DW350_RS18435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DW350_RS18440	COG2084	Dehydrogenase
DW350_RS18460	COG1309	transcriptional regulator
DW350_RS18465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DW350_RS18475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DW350_RS18480	COG2205	protein histidine kinase activity
DW350_RS18485	COG0745	RESPONSE REGULATOR receiver
DW350_RS18490	COG2204	response regulator
DW350_RS18495	COG3852	Histidine kinase
DW350_RS18510	COG0174	glutamine synthetase
DW350_RS18520	COG1217	gtp-binding protein TYPA
DW350_RS18545	COG0583	DNA-binding transcription factor activity
DW350_RS18550	COG2308	Evidence 4 Homologs of previously reported genes of
DW350_RS18570	COG0154	amidase activity
DW350_RS18575	COG1309	transcriptional regulator
DW350_RS18585	COG4771	TonB-dependent receptor
DW350_RS18610	COG0702	epimerase
DW350_RS18700	COG2207	Transcriptional regulator
DW350_RS18705	COG2249	NAD(P)H dehydrogenase (quinone) activity
DW350_RS18710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DW350_RS18730	COG0179	Fumarylacetoacetate (FAA) hydrolase
DW350_RS18745	COG2204	response regulator
DW350_RS18755	COG3237	CsbD-like
DW350_RS18770	COG1770	oligopeptidase
DW350_RS18780	COG2197	response regulator
DW350_RS18800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DW350_RS18810	COG1414	Transcriptional regulator
DW350_RS18820	COG1454	alcohol dehydrogenase
DW350_RS18825	COG2610	gluconate transmembrane transporter activity
DW350_RS18845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DW350_RS18850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DW350_RS18855	COG0805	protein transport
DW350_RS18865	COG0084	hydrolase, TatD family'
DW350_RS18875	COG0463	Glycosyl transferase, family 2
DW350_RS18885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DW350_RS18905	COG0248	Ppx GppA phosphatase
DW350_RS18915	COG3118	belongs to the thioredoxin family
DW350_RS18920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DW350_RS18955	COG1587	Uroporphyrinogen-III synthase
DW350_RS18975	COG1965	Belongs to the frataxin family
DW350_RS19005	COG1011	Hydrolase
DW350_RS19010	COG0210	DNA helicase
DW350_RS19015	COG0740	serine-type endopeptidase activity
DW350_RS19040	COG0018	arginyl-trna synthetase
DW350_RS19045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW350_RS19060	COG0456	acetyltransferase
DW350_RS19065	COG0783	Belongs to the Dps family
DW350_RS19070	COG1490	D-aminoacyl-tRNA deacylase activity
DW350_RS19080	COG1295	ribonuclease BN
DW350_RS19100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW350_RS19110	COG0204	Acyl-transferase
DW350_RS19115	COG0204	Acyl-transferase
DW350_RS19120	COG1166	arginine decarboxylase activity
DW350_RS19125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DW350_RS19145	COG0606	chelatase, subunit chli
DW350_RS19160	COG2960	long-chain fatty acid transporting porin activity
DW350_RS19165	COG1309	transcriptional regulator
DW350_RS19170	COG0210	DNA helicase
DW350_RS19175	COG3300	MHYT domain
DW350_RS19175	COG5001	Diguanylate cyclase
DW350_RS19200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DW350_RS19215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DW350_RS19230	COG2814	Major facilitator Superfamily
DW350_RS19250	COG4221	oxidoreductase activity
DW350_RS19260	COG0300	oxidoreductase activity
DW350_RS19265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DW350_RS19270	COG1349	DNA-binding transcription factor activity
DW350_RS19280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DW350_RS19285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DW350_RS19290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DW350_RS19295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DW350_RS19300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DW350_RS19305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DW350_RS19310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DW350_RS19320	COG0356	it plays a direct role in the translocation of protons across the membrane
DW350_RS19330	COG1475	DNA binding
DW350_RS19350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DW350_RS19360	COG1566	PFAM secretion protein HlyD family protein
DW350_RS19370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DW350_RS19375	COG0583	DNA-binding transcription factor activity
DW350_RS19390	COG0706	membrane insertase activity
DW350_RS19395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DW350_RS19400	COG0594	ribonuclease P activity
DW350_RS19405	COG0230	Belongs to the bacterial ribosomal protein bL34 family