locus-tag	class	description
DB847_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DB847_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DB847_RS00020	COG0187	DNA topoisomerase II activity
DB847_RS00025	COG3977	Valine--pyruvate aminotransferase
DB847_RS00045	COG0751	glycine-tRNA ligase activity
DB847_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
DB847_RS00055	COG2119	membrane
DB847_RS00060	COG2818	Glycosylase
DB847_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
DB847_RS00070	COG1653	transport
DB847_RS00085	COG0006	proline dipeptidase activity
DB847_RS00090	COG1739	Uncharacterized protein family UPF0029
DB847_RS00100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
DB847_RS00160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DB847_RS00165	COG3437	response regulator, receiver
DB847_RS00165	COG0784	Response regulator, receiver
DB847_RS00175	COG2771	luxR family
DB847_RS00185	COG0811	peptide transport
DB847_RS00190	COG0811	peptide transport
DB847_RS00195	COG0848	biopolymer transport protein
DB847_RS00255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DB847_RS00295	COG0390	transport system, permease component
DB847_RS00300	COG1136	(ABC) transporter
DB847_RS00300	COG0577	efflux transmembrane transporter activity
DB847_RS00315	COG0166	Belongs to the GPI family
DB847_RS00320	COG0789	Transcriptional regulator
DB847_RS00340	COG3084	Protein conserved in bacteria
DB847_RS00345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DB847_RS00350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB847_RS00370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DB847_RS00400	COG3655	Transcriptional regulator
DB847_RS00410	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DB847_RS00425	COG1309	transcriptional regulator
DB847_RS00450	COG1879	ABC-type sugar transport system periplasmic component
DB847_RS00460	COG1349	DNA-binding transcription factor activity
DB847_RS00470	COG2222	sugar isomerase
DB847_RS00475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS00480	COG3715	PTS system
DB847_RS00490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS00505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS00515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DB847_RS00565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DB847_RS00570	COG0583	DNA-binding transcription factor activity
DB847_RS00575	COG3447	MASE1 domain protein
DB847_RS00575	COG5001	Diguanylate cyclase
DB847_RS00575	COG5002	protein histidine kinase activity
DB847_RS00580	COG3012	SEC-C Motif Domain Protein
DB847_RS00590	COG0514	ATP-dependent DNA helicase (RecQ)
DB847_RS00600	COG2990	Protein conserved in bacteria
DB847_RS00610	COG1441	menaquinone biosynthetic process
DB847_RS00625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DB847_RS00630	COG1169	isochorismate synthase
DB847_RS00635	COG1575	Belongs to the MenA family. Type 1 subfamily
DB847_RS00650	COG0840	transmembrane signaling receptor activity
DB847_RS00670	COG0519	Catalyzes the synthesis of GMP from XMP
DB847_RS00700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DB847_RS00705	COG2022	thiamine diphosphate biosynthetic process
DB847_RS00710	COG2104	thiamine diphosphate biosynthetic process
DB847_RS00715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DB847_RS00745	COG1737	Transcriptional regulator
DB847_RS00760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB847_RS00765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB847_RS00780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DB847_RS00785	COG0671	phosphoesterase, PA-phosphatase related
DB847_RS00800	COG2076	Multidrug Resistance protein
DB847_RS00805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DB847_RS00810	COG0726	polysaccharide deacetylase
DB847_RS00815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DB847_RS00815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB847_RS00835	COG0589	response to stress
DB847_RS00840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DB847_RS00845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DB847_RS00850	COG1758	RNA polymerase activity
DB847_RS00860	COG2860	membrane
DB847_RS00890	COG4681	YaeQ
DB847_RS00935	COG1561	YicC-like family, N-terminal region
DB847_RS00940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DB847_RS00945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DB847_RS00950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DB847_RS00970	COG1309	transcriptional regulator
DB847_RS00975	COG0756	dUTP diphosphatase activity
DB847_RS00980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DB847_RS00985	COG0456	acetyltransferase
DB847_RS00990	COG4942	peptidase
DB847_RS00995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DB847_RS01000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DB847_RS01005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DB847_RS01010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DB847_RS01015	COG0316	Belongs to the HesB IscA family
DB847_RS01015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DB847_RS01020	COG1040	competence protein
DB847_RS01025	COG0596	Alpha beta hydrolase
DB847_RS01040	COG2183	response to ionizing radiation
DB847_RS01045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DB847_RS01060	COG1940	carbohydrate kinase activity
DB847_RS01065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB847_RS01070	COG2731	YhcH YjgK YiaL family protein
DB847_RS01080	COG2186	Transcriptional regulator
DB847_RS01085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DB847_RS01100	COG3031	protein transport across the cell outer membrane
DB847_RS01115	COG1459	type II secretion system
DB847_RS01120	COG2165	general secretion pathway protein
DB847_RS01135	COG4795	General secretion pathway protein
DB847_RS01140	COG3156	type II secretion system protein K
DB847_RS01150	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DB847_RS01160	COG0798	PFAM Bile acid sodium symporter
DB847_RS01165	COG0640	Transcriptional regulator
DB847_RS01185	COG0051	transcription antitermination factor activity, RNA binding
DB847_RS01190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DB847_RS01195	COG0088	Forms part of the polypeptide exit tunnel
DB847_RS01200	COG0089	rRNA binding
DB847_RS01205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DB847_RS01210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DB847_RS01215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DB847_RS01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DB847_RS01225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DB847_RS01235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DB847_RS01240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DB847_RS01245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DB847_RS01250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DB847_RS01255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DB847_RS01260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DB847_RS01265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DB847_RS01270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DB847_RS01275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DB847_RS01280	COG1841	ribosomal large subunit assembly
DB847_RS01285	COG0200	Binds to the 23S rRNA
DB847_RS01290	COG0201	protein transport
DB847_RS01295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DB847_RS01300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DB847_RS01305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DB847_RS01315	COG0202	RNA polymerase activity
DB847_RS01320	COG0203	ribosomal protein L17
DB847_RS01360	COG0659	secondary active sulfate transmembrane transporter activity
DB847_RS01365	COG2205	protein histidine kinase activity
DB847_RS01375	COG2204	response regulator
DB847_RS01390	COG4191	Histidine kinase
DB847_RS01420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DB847_RS01430	COG0814	amino acid
DB847_RS01435	COG0814	amino acid
DB847_RS01445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DB847_RS01450	COG0569	domain protein
DB847_RS01455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DB847_RS01480	COG1187	pseudouridine synthase activity
DB847_RS01485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DB847_RS01490	COG2226	methyltransferase
DB847_RS01520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DB847_RS01530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DB847_RS01540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DB847_RS01545	COG0222	ribosome binding
DB847_RS01550	COG0085	RNA polymerase activity
DB847_RS01555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DB847_RS01560	COG4628	conserved protein (DUF2132)
DB847_RS01570	COG0583	DNA-binding transcription factor activity
DB847_RS01585	COG1294	oxidase, subunit
DB847_RS01600	COG2855	membrane
DB847_RS01625	COG0564	pseudouridine synthase activity
DB847_RS01630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB847_RS01665	COG2207	Transcriptional regulator
DB847_RS01670	COG0697	spore germination
DB847_RS01680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DB847_RS01680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DB847_RS01685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DB847_RS01690	COG1074	ATP-dependent DNA helicase activity
DB847_RS01695	COG1074	ATP-dependent DNA helicase activity
DB847_RS01700	COG1074	ATP-dependent DNA helicase activity
DB847_RS01735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DB847_RS01745	COG2200	EAL domain
DB847_RS01745	COG2199	diguanylate cyclase activity
DB847_RS01790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DB847_RS01795	COG1459	type II secretion system
DB847_RS01810	COG2165	general secretion pathway protein
DB847_RS01830	COG1077	Cell shape determining protein MreB Mrl
DB847_RS01835	COG1792	Involved in formation and maintenance of cell shape
DB847_RS01840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DB847_RS01845	COG0424	maF-like protein
DB847_RS01850	COG1530	ribonuclease E activity
DB847_RS01855	COG3164	Protein of unknown function
DB847_RS01860	COG0312	modulator of DNA gyrase
DB847_RS01870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DB847_RS01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB847_RS01880	COG4558	Periplasmic binding protein
DB847_RS01885	COG0848	biopolymer transport protein
DB847_RS01890	COG0811	peptide transport
DB847_RS01895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DB847_RS01915	COG0748	coenzyme F420 binding
DB847_RS01920	COG0748	coenzyme F420 binding
DB847_RS01940	COG3028	Belongs to the UPF0307 family
DB847_RS01945	COG0312	modulator of DNA gyrase
DB847_RS01955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS01960	COG1660	Displays ATPase and GTPase activities
DB847_RS01970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DB847_RS01975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DB847_RS01980	COG1137	ATPase activity
DB847_RS01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DB847_RS01995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DB847_RS02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DB847_RS02020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DB847_RS02025	COG2854	intermembrane phospholipid transfer
DB847_RS02035	COG5007	Belongs to the BolA IbaG family
DB847_RS02040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DB847_RS02050	COG4106	trans-aconitate 2-methyltransferase activity
DB847_RS02060	COG0583	DNA-binding transcription factor activity
DB847_RS02070	COG4221	oxidoreductase activity
DB847_RS02095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DB847_RS02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DB847_RS02115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DB847_RS02120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DB847_RS02125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DB847_RS02130	COG0625	glutathione transferase activity
DB847_RS02135	COG2969	positive regulation of protein catabolic process
DB847_RS02155	COG2823	Periplasmic or secreted lipoprotein
DB847_RS02160	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DB847_RS02165	COG0792	nuclease activity
DB847_RS02170	COG3107	peptidoglycan biosynthetic process
DB847_RS02175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DB847_RS02190	COG2001	Belongs to the MraZ family
DB847_RS02195	COG0275	rRNA processing
DB847_RS02200	COG3116	cell division
DB847_RS02220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB847_RS02230	COG0772	Belongs to the SEDS family
DB847_RS02235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DB847_RS02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DB847_RS02245	COG1181	Belongs to the D-alanine--D-alanine ligase family
DB847_RS02250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DB847_RS02255	COG0849	cell division
DB847_RS02260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DB847_RS02265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DB847_RS02270	COG0653	protein targeting
DB847_RS02275	COG0494	nUDIX hydrolase
DB847_RS02290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DB847_RS02290	COG0237	dephospho-CoA kinase activity
DB847_RS02300	COG1459	type II secretion system
DB847_RS02305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DB847_RS02320	COG0157	Belongs to the NadC ModD family
DB847_RS02330	COG2186	Transcriptional regulator
DB847_RS02335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DB847_RS02340	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB847_RS02345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DB847_RS02360	COG3118	belongs to the thioredoxin family
DB847_RS02390	COG0814	amino acid
DB847_RS02405	COG2916	Histone family protein nucleoid-structuring protein H-NS
DB847_RS02420	COG3089	Belongs to the UPF0270 family
DB847_RS02425	COG1765	OsmC-like protein
DB847_RS02435	COG2084	Dehydrogenase
DB847_RS02440	COG0488	(ABC) transporter
DB847_RS02455	COG1047	Peptidyl-prolyl cis-trans
DB847_RS02480	COG2962	Rard protein
DB847_RS02485	COG0673	inositol 2-dehydrogenase activity
DB847_RS02490	COG0456	acetyltransferase
DB847_RS02505	COG0545	Peptidyl-prolyl cis-trans isomerase
DB847_RS02520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DB847_RS02525	COG1027	Aspartate ammonia-lyase
DB847_RS02530	COG3030	protein affecting phage T7 exclusion by the F plasmid
DB847_RS02540	COG0534	Mate efflux family protein
DB847_RS02545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DB847_RS02550	COG0459	protein refolding
DB847_RS02570	COG0471	metal ion transport
DB847_RS02580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DB847_RS02590	COG2190	(PTS) system
DB847_RS02590	COG1263	PTS System
DB847_RS02590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS02595	COG2723	6-phospho-beta-galactosidase activity
DB847_RS02600	COG1609	Transcriptional regulator
DB847_RS02630	COG3311	Transcriptional regulator
DB847_RS02655	COG0582	viral genome integration into host DNA
DB847_RS02660	COG2203	Gaf domain
DB847_RS02660	COG3706	GGDEF domain
DB847_RS02660	COG4251	negative regulation of phosphorylation
DB847_RS02660	COG5001	Diguanylate cyclase
DB847_RS02680	COG0297	glycogen (starch) synthase activity
DB847_RS02685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DB847_RS02690	COG2813	Specifically methylates the guanine in position
DB847_RS02725	COG0741	lytic transglycosylase activity
DB847_RS02730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DB847_RS02750	COG2703	oxygen carrier activity
DB847_RS02760	COG1194	a g-specific adenine glycosylase
DB847_RS02765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DB847_RS02770	COG2066	Belongs to the glutaminase family
DB847_RS02785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB847_RS02790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DB847_RS02795	COG1872	DUF167
DB847_RS02800	COG0762	integral membrane protein
DB847_RS02805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DB847_RS02810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DB847_RS02830	COG3022	response to hydroperoxide
DB847_RS02835	COG4221	oxidoreductase activity
DB847_RS02840	COG0583	DNA-binding transcription factor activity
DB847_RS02850	COG1522	sequence-specific DNA binding
DB847_RS02855	COG2502	aspartate--ammonia ligase
DB847_RS02860	COG0513	Belongs to the DEAD box helicase family
DB847_RS02865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DB847_RS02895	COG0716	FMN binding
DB847_RS02960	COG0454	-acetyltransferase
DB847_RS02985	COG2850	peptidyl-arginine hydroxylation
DB847_RS02995	COG0546	phosphoglycolate phosphatase activity
DB847_RS03010	COG1309	transcriptional regulator
DB847_RS03015	COG4191	Histidine kinase
DB847_RS03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS03030	COG2252	PERMEase
DB847_RS03035	COG3112	Uncharacterised protein family (UPF0231)
DB847_RS03040	COG1605	Chorismate mutase
DB847_RS03050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DB847_RS03055	COG0835	chemotaxis
DB847_RS03080	COG0456	acetyltransferase
DB847_RS03105	COG1560	Kdo2-lipid A biosynthetic process
DB847_RS03110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DB847_RS03110	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DB847_RS03120	COG0589	response to stress
DB847_RS03175	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
DB847_RS03185	COG0481	GTPase activity
DB847_RS03195	COG0571	ribonuclease III activity
DB847_RS03210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DB847_RS03220	COG0431	NADPH-dependent FMN reductase
DB847_RS03230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DB847_RS03250	COG1484	DNA-dependent DNA replication
DB847_RS03255	COG4584	PFAM Integrase catalytic
DB847_RS03275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DB847_RS03280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DB847_RS03285	COG3956	TIGRFAM MazG family protein
DB847_RS03290	COG0504	CTP synthase activity
DB847_RS03295	COG0148	phosphopyruvate hydratase activity
DB847_RS03315	COG0084	hydrolase, TatD family'
DB847_RS03320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DB847_RS03325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DB847_RS03335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DB847_RS03345	COG2116	formate transmembrane transporter activity
DB847_RS03355	COG3111	PFAM Bacterial OB fold (BOF) protein
DB847_RS03370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DB847_RS03390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DB847_RS03395	COG0651	ATP synthesis coupled electron transport
DB847_RS03400	COG0650	Formate hydrogenlyase subunit 4
DB847_RS03410	COG4237	Hydrogenase 4 membrane
DB847_RS03415	COG0651	ATP synthesis coupled electron transport
DB847_RS03420	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DB847_RS03420	COG3261	NADH dehydrogenase
DB847_RS03425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS03430	COG3260	NADH ubiquinone oxidoreductase 20
DB847_RS03440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DB847_RS03445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DB847_RS03505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DB847_RS03510	COG3383	formate dehydrogenase (NAD+) activity
DB847_RS03515	COG0303	'Molybdopterin
DB847_RS03520	COG0746	molybdenum cofactor guanylyltransferase activity
DB847_RS03530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DB847_RS03535	COG0521	Mo-molybdopterin cofactor biosynthetic process
DB847_RS03545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DB847_RS03570	COG0697	spore germination
DB847_RS03580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DB847_RS03585	COG1584	GPR1 FUN34 yaaH family protein
DB847_RS03600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DB847_RS03605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DB847_RS03625	COG0739	heme binding
DB847_RS03630	COG1573	uracil-dna glycosylase
DB847_RS03645	COG3068	Protein conserved in bacteria
DB847_RS03650	COG0776	regulation of translation
DB847_RS03665	COG0151	Belongs to the GarS family
DB847_RS03680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DB847_RS03690	COG1982	Orn Lys Arg decarboxylase major
DB847_RS03695	COG0531	amino acid
DB847_RS03705	COG3710	Transcriptional regulator
DB847_RS03735	COG4821	SIS domain
DB847_RS03765	COG0505	Belongs to the CarA family
DB847_RS03775	COG3104	oligopeptide transport
DB847_RS03810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DB847_RS03815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DB847_RS03820	COG0375	protein maturation
DB847_RS03845	COG1024	Enoyl-CoA hydratase
DB847_RS03845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB847_RS03865	COG0393	Putative heavy-metal-binding
DB847_RS03875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DB847_RS03920	COG2135	peptidase activity
DB847_RS03935	COG3681	Belongs to the UPF0597 family
DB847_RS03985	COG0121	glutamine amidotransferase
DB847_RS03990	COG3240	lipase activity
DB847_RS04025	COG1484	DNA-dependent DNA replication
DB847_RS04030	COG3220	belongs to the UPF0276 family
DB847_RS04055	COG4166	transmembrane transport
DB847_RS04060	COG0366	Alpha amylase catalytic
DB847_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
DB847_RS04080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DB847_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS04080	COG0300	oxidoreductase activity
DB847_RS04080	COG3321	synthase
DB847_RS04105	COG2130	NADP-dependent
DB847_RS04120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS04125	COG1554	hydrolase, family 65, central catalytic
DB847_RS04140	COG1263	PTS System
DB847_RS04140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS04145	COG0784	Response regulator, receiver
DB847_RS04145	COG3437	response regulator, receiver
DB847_RS04155	COG1609	Transcriptional regulator
DB847_RS04190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DB847_RS04225	COG0583	DNA-binding transcription factor activity
DB847_RS04255	COG1454	alcohol dehydrogenase
DB847_RS04295	COG1070	Carbohydrate kinase
DB847_RS04330	COG1609	Transcriptional regulator
DB847_RS04330	COG2207	Transcriptional regulator
DB847_RS04375	COG1136	(ABC) transporter
DB847_RS04375	COG0577	efflux transmembrane transporter activity
DB847_RS04385	COG1136	(ABC) transporter
DB847_RS04385	COG0577	efflux transmembrane transporter activity
DB847_RS04390	COG0577	efflux transmembrane transporter activity
DB847_RS04390	COG1136	(ABC) transporter
DB847_RS04395	COG1538	Outer membrane efflux protein
DB847_RS04420	COG2814	Major facilitator Superfamily
DB847_RS04460	COG1392	Phosphate transport regulator
DB847_RS04490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DB847_RS04500	COG2916	Histone family protein nucleoid-structuring protein H-NS
DB847_RS04545	COG1994	Peptidase M50
DB847_RS04555	COG1444	tRNA N-acetyltransferase activity
DB847_RS04560	COG1444	tRNA N-acetyltransferase activity
DB847_RS04570	COG1355	regulation of microtubule-based process
DB847_RS04580	COG2078	PFAM AMMECR1 domain protein
DB847_RS04580	COG3885	ferrous iron binding
DB847_RS04585	COG2190	(PTS) system
DB847_RS04590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DB847_RS04595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS04600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DB847_RS04625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DB847_RS04635	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DB847_RS04640	COG3079	Belongs to the UPF0149 family
DB847_RS04665	COG3735	TraB family
DB847_RS04695	COG3188	usher protein
DB847_RS04730	COG1484	DNA-dependent DNA replication
DB847_RS04770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DB847_RS04775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DB847_RS04780	COG0732	type I restriction modification DNA specificity domain
DB847_RS04810	COG0494	nUDIX hydrolase
DB847_RS04855	COG0835	chemotaxis
DB847_RS04855	COG0784	Response regulator, receiver
DB847_RS04860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DB847_RS04865	COG1815	bacterial-type flagellum-dependent cell motility
DB847_RS04885	COG4787	bacterial-type flagellum-dependent cell motility
DB847_RS04895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DB847_RS04900	COG1706	bacterial-type flagellum-dependent cell motility
DB847_RS04905	COG1705	Flagellar rod assembly protein muramidase FlgJ
DB847_RS04905	COG3951	Flagellar rod assembly protein muramidase FlgJ
DB847_RS04910	COG1256	bacterial-type flagellum assembly
DB847_RS04910	COG4786	Flagellar basal body rod
DB847_RS04930	COG1334	flagellar protein FlaG
DB847_RS04935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DB847_RS04945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DB847_RS04955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DB847_RS04960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DB847_RS04970	COG1083	cytidylyl-transferase
DB847_RS04985	COG0107	imidazoleglycerol-phosphate synthase activity
DB847_RS04990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DB847_RS05000	COG2089	acid synthase
DB847_RS05010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DB847_RS05020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DB847_RS05025	COG2089	acid synthase
DB847_RS05030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB847_RS05045	COG1083	cytidylyl-transferase
DB847_RS05050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DB847_RS05055	COG1086	Polysaccharide biosynthesis protein
DB847_RS05090	COG1677	Flagellar hook-basal body complex protein FliE
DB847_RS05095	COG1766	The M ring may be actively involved in energy transduction
DB847_RS05150	COG1987	bacterial-type flagellum assembly
DB847_RS05155	COG1684	flagellar biosynthetic protein fliR
DB847_RS05190	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DB847_RS05195	COG2198	Histidine kinase
DB847_RS05195	COG0784	Response regulator, receiver
DB847_RS05195	COG0643	Histidine kinase
DB847_RS05200	COG2201	protein-glutamate methylesterase activity
DB847_RS05205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DB847_RS05210	COG1360	Flagellar Motor Protein
DB847_RS05225	COG0835	chemotaxis
DB847_RS05235	COG3139	Protein of unknown function (DUF1315)
DB847_RS05245	COG0616	signal peptide processing
DB847_RS05250	COG0778	Nitroreductase
DB847_RS05255	COG0017	Asparaginyl-tRNA synthetase
DB847_RS05265	COG0840	transmembrane signaling receptor activity
DB847_RS05270	COG0500	methyltransferase
DB847_RS05275	COG4106	trans-aconitate 2-methyltransferase activity
DB847_RS05285	COG0814	amino acid
DB847_RS05295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DB847_RS05300	COG0217	transcriptional regulatory protein
DB847_RS05320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DB847_RS05325	COG0632	four-way junction helicase activity
DB847_RS05330	COG2255	four-way junction helicase activity
DB847_RS05340	COG1294	oxidase, subunit
DB847_RS05360	COG0811	peptide transport
DB847_RS05375	COG0823	Involved in the tonB-independent uptake of proteins
DB847_RS05380	COG2885	chlorophyll binding
DB847_RS05385	COG2885	chlorophyll binding
DB847_RS05460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DB847_RS05480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DB847_RS05485	COG1640	4-alpha-glucanotransferase
DB847_RS05490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DB847_RS05525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DB847_RS05535	COG1061	Type III restriction enzyme res subunit
DB847_RS05540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DB847_RS05545	COG0277	FAD linked oxidase domain protein
DB847_RS05545	COG0247	lactate metabolic process
DB847_RS05550	COG2050	protein possibly involved in aromatic compounds catabolism
DB847_RS05570	COG2814	Major facilitator Superfamily
DB847_RS05585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB847_RS05595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DB847_RS05600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DB847_RS05630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DB847_RS05635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DB847_RS05635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DB847_RS05650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DB847_RS05655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB847_RS05660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DB847_RS05720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB847_RS05725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB847_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS05755	COG1021	2,3-dihydroxybenzoate-AMP ligase
DB847_RS05765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DB847_RS05810	COG1091	dTDP-4-dehydrorhamnose reductase activity
DB847_RS05830	COG2350	Protein conserved in bacteria
DB847_RS05835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DB847_RS05850	COG2917	probably involved in intracellular septation
DB847_RS05855	COG4115	mRNA cleavage
DB847_RS05860	COG2161	toxin-antitoxin pair type II binding
DB847_RS05880	COG1733	regulation of RNA biosynthetic process
DB847_RS05890	COG0159	tryptophan synthase activity
DB847_RS05895	COG0133	tryptophan synthase activity
DB847_RS05900	COG0135	phosphoribosylanthranilate isomerase activity
DB847_RS05900	COG0134	indole-3-glycerol-phosphate synthase activity
DB847_RS05905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DB847_RS05910	COG0512	Glutamine amidotransferase of anthranilate synthase
DB847_RS05915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DB847_RS05930	COG0009	L-threonylcarbamoyladenylate synthase
DB847_RS05940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DB847_RS05945	COG1187	pseudouridine synthase activity
DB847_RS05960	COG0667	Aldo Keto reductase
DB847_RS05965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DB847_RS05970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DB847_RS05975	COG0443	Heat shock 70 kDa protein
DB847_RS05980	COG0484	heat shock protein binding
DB847_RS05985	COG4584	PFAM Integrase catalytic
DB847_RS05990	COG1484	DNA-dependent DNA replication
DB847_RS06025	COG0583	DNA-binding transcription factor activity
DB847_RS06035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DB847_RS06040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DB847_RS06055	COG0617	tRNA 3'-terminal CCA addition
DB847_RS06060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB847_RS06070	COG1489	DNA binding
DB847_RS06145	COG0625	glutathione transferase activity
DB847_RS06155	COG2154	pterin-4-alpha-carbinolamine dehydratase
DB847_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS06195	COG1802	Transcriptional regulator
DB847_RS06205	COG0579	oxidoreductase
DB847_RS06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB847_RS06220	COG0583	DNA-binding transcription factor activity
DB847_RS06225	COG4895	conserved protein (DUF2196)
DB847_RS06240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DB847_RS06245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DB847_RS06250	COG1473	amidohydrolase
DB847_RS06260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DB847_RS06265	COG0066	3-isopropylmalate dehydratase activity
DB847_RS06270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DB847_RS06275	COG0840	transmembrane signaling receptor activity
DB847_RS06300	COG1253	flavin adenine dinucleotide binding
DB847_RS06305	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DB847_RS06320	COG2867	negative regulation of translational initiation
DB847_RS06325	COG2914	Belongs to the UPF0125 (RnfH) family
DB847_RS06330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB847_RS06335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DB847_RS06345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DB847_RS06355	COG3104	oligopeptide transport
DB847_RS06365	COG1073	alpha beta
DB847_RS06370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DB847_RS06380	COG0840	transmembrane signaling receptor activity
DB847_RS06385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DB847_RS06390	COG0077	Prephenate dehydratase
DB847_RS06390	COG1605	Chorismate mutase
DB847_RS06395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DB847_RS06410	COG1609	Transcriptional regulator
DB847_RS06415	COG1607	acyl-coa hydrolase
DB847_RS06425	COG1388	LysM domain
DB847_RS06425	COG0741	lytic transglycosylase activity
DB847_RS06430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB847_RS06440	COG0328	RNA-DNA hybrid ribonuclease activity
DB847_RS06455	COG3437	response regulator, receiver
DB847_RS06455	COG0784	Response regulator, receiver
DB847_RS06460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DB847_RS06465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DB847_RS06475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DB847_RS06490	COG1393	Belongs to the ArsC family
DB847_RS06505	COG2897	thiosulfate sulfurtransferase activity
DB847_RS06510	COG3118	belongs to the thioredoxin family
DB847_RS06525	COG1012	belongs to the aldehyde dehydrogenase family
DB847_RS06540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DB847_RS06550	COG1196	nuclear chromosome segregation
DB847_RS06555	COG1196	nuclear chromosome segregation
DB847_RS06560	COG3115	cell septum assembly
DB847_RS06565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DB847_RS06565	COG0456	acetyltransferase
DB847_RS06605	COG1484	DNA-dependent DNA replication
DB847_RS06655	COG0724	RNA recognition motif
DB847_RS06660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DB847_RS06670	COG3122	Protein conserved in bacteria
DB847_RS06685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DB847_RS06710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DB847_RS06730	COG0156	8-amino-7-oxononanoate synthase activity
DB847_RS06735	COG2226	methyltransferase
DB847_RS06740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DB847_RS06745	COG0501	Belongs to the peptidase M48B family
DB847_RS06785	COG0633	Ferredoxin
DB847_RS06805	COG0693	protein deglycase activity
DB847_RS06810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DB847_RS06815	COG1666	GTP binding
DB847_RS06820	COG0531	amino acid
DB847_RS06835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DB847_RS06845	COG0729	surface antigen
DB847_RS06885	COG1534	Rna-binding protein
DB847_RS06890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DB847_RS06900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DB847_RS06905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DB847_RS06910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DB847_RS06930	COG0195	Participates in both transcription termination and antitermination
DB847_RS06935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DB847_RS06940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DB847_RS06945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DB847_RS06950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DB847_RS06965	COG0747	negative chemotaxis
DB847_RS06970	COG0601	transmembrane transport
DB847_RS06980	COG2207	Transcriptional regulator
DB847_RS07015	COG1289	transmembrane transporter activity
DB847_RS07020	COG1185	polyribonucleotide nucleotidyltransferase activity
DB847_RS07035	COG0483	inositol monophosphate 1-phosphatase activity
DB847_RS07040	COG0840	transmembrane signaling receptor activity
DB847_RS07065	COG1030	water channel activity
DB847_RS07075	COG0330	HflC and HflK could
DB847_RS07080	COG1940	carbohydrate kinase activity
DB847_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
DB847_RS07090	COG1454	alcohol dehydrogenase
DB847_RS07100	COG0601	transmembrane transport
DB847_RS07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB847_RS07155	COG1362	aminopeptidase activity
DB847_RS07185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB847_RS07215	COG1815	bacterial-type flagellum-dependent cell motility
DB847_RS07220	COG1558	bacterial-type flagellum-dependent cell motility
DB847_RS07230	COG4786	Flagellar basal body rod
DB847_RS07235	COG4787	bacterial-type flagellum-dependent cell motility
DB847_RS07240	COG4786	Flagellar basal body rod
DB847_RS07245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DB847_RS07265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB847_RS07280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DB847_RS07310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DB847_RS07315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB847_RS07320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB847_RS07330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DB847_RS07340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DB847_RS07355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DB847_RS07365	COG1987	bacterial-type flagellum assembly
DB847_RS07410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DB847_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS07450	COG4191	Histidine kinase
DB847_RS07470	COG1484	DNA-dependent DNA replication
DB847_RS07475	COG3069	C4-dicarboxylate transmembrane transporter activity
DB847_RS07485	COG1301	dicarboxylic acid transport
DB847_RS07500	COG3768	UPF0283 membrane protein
DB847_RS07505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DB847_RS07520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DB847_RS07525	COG0584	glycerophosphoryl diester phosphodiesterase
DB847_RS07535	COG3706	GGDEF domain
DB847_RS07540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DB847_RS07550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DB847_RS07575	COG3852	Histidine kinase
DB847_RS07580	COG0326	Molecular chaperone. Has ATPase activity
DB847_RS07585	COG0784	Response regulator, receiver
DB847_RS07585	COG3437	response regulator, receiver
DB847_RS07590	COG2201	protein-glutamate methylesterase activity
DB847_RS07600	COG0643	Histidine kinase
DB847_RS07600	COG2198	Histidine kinase
DB847_RS07605	COG0643	Histidine kinase
DB847_RS07605	COG2198	Histidine kinase
DB847_RS07615	COG0835	chemotaxis
DB847_RS07630	COG0840	transmembrane signaling receptor activity
DB847_RS07630	COG3290	protein histidine kinase activity
DB847_RS07640	COG3038	cytochrome b561
DB847_RS07645	COG2353	YceI-like domain
DB847_RS07660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS07670	COG0484	heat shock protein binding
DB847_RS07675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB847_RS07720	COG0602	queuosine metabolic process
DB847_RS07730	COG1253	flavin adenine dinucleotide binding
DB847_RS07735	COG0563	adenylate kinase activity
DB847_RS07740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DB847_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS07765	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB847_RS07765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB847_RS07930	COG0047	phosphoribosylformylglycinamidine synthase activity
DB847_RS07930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DB847_RS07945	COG3437	response regulator, receiver
DB847_RS07945	COG0784	Response regulator, receiver
DB847_RS07950	COG0534	Mate efflux family protein
DB847_RS07955	COG2837	iron assimilation
DB847_RS07960	COG4191	Histidine kinase
DB847_RS07965	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DB847_RS07975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB847_RS07980	COG1446	asparaginase
DB847_RS07985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DB847_RS07990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB847_RS07995	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB847_RS08025	COG1876	peptidase activity
DB847_RS08035	COG1393	Belongs to the ArsC family
DB847_RS08070	COG0281	malic enzyme
DB847_RS08080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DB847_RS08115	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DB847_RS08125	COG2233	PERMEase
DB847_RS08130	COG1902	pentaerythritol trinitrate reductase activity
DB847_RS08135	COG0583	DNA-binding transcription factor activity
DB847_RS08145	COG5001	Diguanylate cyclase
DB847_RS08145	COG4251	negative regulation of phosphorylation
DB847_RS08145	COG3706	GGDEF domain
DB847_RS08145	COG2203	Gaf domain
DB847_RS08150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB847_RS08155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DB847_RS08160	COG2716	regulation of RNA biosynthetic process
DB847_RS08165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB847_RS08170	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DB847_RS08175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DB847_RS08185	COG1073	alpha beta
DB847_RS08205	COG0798	PFAM Bile acid sodium symporter
DB847_RS08215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB847_RS08220	COG1595	DNA-templated transcription, initiation
DB847_RS08250	COG1349	DNA-binding transcription factor activity
DB847_RS08285	COG2211	Major facilitator Superfamily
DB847_RS08295	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB847_RS08305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DB847_RS08310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DB847_RS08315	COG1984	allophanate hydrolase subunit 2
DB847_RS08365	COG0544	peptidyl-prolyl cis-trans isomerase activity
DB847_RS08370	COG0740	serine-type endopeptidase activity
DB847_RS08375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DB847_RS08380	COG2195	Cleaves the N-terminal amino acid of tripeptides
DB847_RS08400	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB847_RS08400	COG0596	Alpha beta hydrolase
DB847_RS08405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DB847_RS08410	COG0033	Phosphoglucomutase
DB847_RS08425	COG0058	SHG alpha-glucan phosphorylase activity
DB847_RS08440	COG0531	amino acid
DB847_RS08445	COG0531	amino acid
DB847_RS08465	COG0745	RESPONSE REGULATOR receiver
DB847_RS08470	COG5000	phosphorelay sensor kinase activity
DB847_RS08510	COG2062	phosphohistidine phosphatase, SixA
DB847_RS08525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DB847_RS08525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DB847_RS08530	COG1024	Enoyl-CoA hydratase
DB847_RS08535	COG0427	acetyl-CoA hydrolase
DB847_RS08555	COG1115	amino acid carrier protein
DB847_RS08600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DB847_RS08605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DB847_RS08620	COG0437	4 iron, 4 sulfur cluster binding
DB847_RS08625	COG3302	dmso reductase anchor subunit
DB847_RS08630	COG0730	response to heat
DB847_RS08650	COG2873	o-acetylhomoserine
DB847_RS08670	COG2205	protein histidine kinase activity
DB847_RS08670	COG3437	response regulator, receiver
DB847_RS08670	COG3850	Histidine kinase
DB847_RS08670	COG4999	Histidine kinase
DB847_RS08675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DB847_RS08685	COG4251	negative regulation of phosphorylation
DB847_RS08715	COG0488	(ABC) transporter
DB847_RS08720	COG0513	Belongs to the DEAD box helicase family
DB847_RS08725	COG0596	Alpha beta hydrolase
DB847_RS08725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DB847_RS08730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DB847_RS08760	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DB847_RS08765	COG0420	3'-5' exonuclease activity
DB847_RS08770	COG0419	ATPase involved in DNA repair
DB847_RS08775	COG0419	ATPase involved in DNA repair
DB847_RS08780	COG0625	glutathione transferase activity
DB847_RS08805	COG0833	amino acid
DB847_RS08815	COG1757	Na H antiporter
DB847_RS08830	COG1757	Na H antiporter
DB847_RS09010	COG4139	cobalamin transport
DB847_RS09015	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
DB847_RS09020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DB847_RS09035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DB847_RS09040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DB847_RS09040	COG0574	Belongs to the PEP-utilizing enzyme family
DB847_RS09050	COG2974	May be involved in recombination
DB847_RS09065	COG1250	3-hydroxyacyl-CoA dehydrogenase
DB847_RS09090	COG4584	PFAM Integrase catalytic
DB847_RS09095	COG1484	DNA-dependent DNA replication
DB847_RS09120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DB847_RS09125	COG2915	High frequency lysogenization protein hflD homolog
DB847_RS09145	COG1278	Cold shock
DB847_RS09150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DB847_RS09155	COG0542	response to heat
DB847_RS09160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DB847_RS09175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DB847_RS09190	COG0745	RESPONSE REGULATOR receiver
DB847_RS09195	COG0492	ferredoxin-NADP+ reductase activity
DB847_RS09200	COG1686	Belongs to the peptidase S11 family
DB847_RS09210	COG0686	Belongs to the AlaDH PNT family
DB847_RS09225	COG0531	amino acid
DB847_RS09225	COG1674	ftsk spoiiie
DB847_RS09230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DB847_RS09240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DB847_RS09250	COG0463	Glycosyl transferase, family 2
DB847_RS09285	COG0604	alcohol dehydrogenase
DB847_RS09300	COG4172	Belongs to the ABC transporter superfamily
DB847_RS09305	COG4172	Belongs to the ABC transporter superfamily
DB847_RS09310	COG4171	peptide transport system, permease
DB847_RS09315	COG4168	peptide transport system, permease
DB847_RS09320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DB847_RS09325	COG1842	Phage shock protein A
DB847_RS09340	COG0564	pseudouridine synthase activity
DB847_RS09345	COG0215	cysteine-tRNA ligase activity
DB847_RS09350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DB847_RS09360	COG0561	phosphatase activity
DB847_RS09380	COG3852	Histidine kinase
DB847_RS09385	COG2201	protein-glutamate methylesterase activity
DB847_RS09395	COG2204	response regulator
DB847_RS09400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DB847_RS09400	COG1116	anion transmembrane transporter activity
DB847_RS09405	COG4251	negative regulation of phosphorylation
DB847_RS09410	COG0784	Response regulator, receiver
DB847_RS09465	COG1132	(ABC) transporter
DB847_RS09470	COG1132	(ABC) transporter
DB847_RS09530	COG1846	Transcriptional regulator
DB847_RS09530	COG1940	carbohydrate kinase activity
DB847_RS09535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DB847_RS09540	COG0363	glucosamine-6-phosphate deaminase activity
DB847_RS09545	COG2190	(PTS) system
DB847_RS09545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS09545	COG1263	PTS System
DB847_RS09555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB847_RS09560	COG1120	ATPase activity
DB847_RS09565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB847_RS09575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DB847_RS09590	COG3961	Belongs to the TPP enzyme family
DB847_RS09595	COG2030	dehydratase
DB847_RS09600	COG0427	acetyl-CoA hydrolase
DB847_RS09605	COG2301	Belongs to the HpcH HpaI aldolase family
DB847_RS09645	COG2181	nitrate reductase activity
DB847_RS09650	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DB847_RS09680	COG0500	methyltransferase
DB847_RS09710	COG1957	nucleoside hydrolase
DB847_RS09725	COG1546	Belongs to the CinA family
DB847_RS09725	COG1058	Belongs to the CinA family
DB847_RS09730	COG1605	Chorismate mutase
DB847_RS09735	COG0471	metal ion transport
DB847_RS09795	COG3102	Protein conserved in bacteria
DB847_RS09820	COG0668	transmembrane transport
DB847_RS09835	COG2814	Major facilitator Superfamily
DB847_RS09860	COG4977	sequence-specific DNA binding
DB847_RS09870	COG1484	DNA-dependent DNA replication
DB847_RS09895	COG2199	diguanylate cyclase activity
DB847_RS09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DB847_RS09900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DB847_RS09900	COG0493	'glutamate synthase
DB847_RS09905	COG0402	S-adenosylhomocysteine deaminase activity
DB847_RS09910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB847_RS09925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DB847_RS09930	COG2252	PERMEase
DB847_RS09935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DB847_RS09950	COG3829	transcription factor binding
DB847_RS09955	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DB847_RS09960	COG0793	Belongs to the peptidase S41A family
DB847_RS09990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DB847_RS10005	COG0583	DNA-binding transcription factor activity
DB847_RS10015	COG0814	amino acid
DB847_RS10025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DB847_RS10035	COG2009	succinate dehydrogenase
DB847_RS10040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DB847_RS10045	COG1053	succinate dehydrogenase
DB847_RS10060	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB847_RS10065	COG0045	succinate-CoA ligase (ADP-forming) activity
DB847_RS10070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DB847_RS10110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DB847_RS10115	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DB847_RS10125	COG2719	SpoVR family
DB847_RS10130	COG2718	Belongs to the UPF0229 family
DB847_RS10135	COG2766	serine protein kinase
DB847_RS10140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DB847_RS10155	COG0308	aminopeptidase N
DB847_RS10170	COG0167	dihydroorotate dehydrogenase activity
DB847_RS10205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DB847_RS10210	COG2894	cell division
DB847_RS10215	COG0850	regulation of cytokinetic process
DB847_RS10220	COG3100	YcgL domain-containing protein
DB847_RS10225	COG2951	lytic endotransglycosylase activity
DB847_RS10260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DB847_RS10265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DB847_RS10265	COG0165	Argininosuccinate lyase
DB847_RS10270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DB847_RS10275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DB847_RS10285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DB847_RS10290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DB847_RS10300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DB847_RS10300	COG0131	Imidazoleglycerol-phosphate dehydratase
DB847_RS10305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DB847_RS10310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DB847_RS10320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DB847_RS10320	COG0140	phosphoribosyl-ATP diphosphatase activity
DB847_RS10410	COG0697	spore germination
DB847_RS10425	COG0384	phenazine biosynthesis protein PhzF
DB847_RS10440	COG0714	Associated with various cellular activities
DB847_RS10510	COG4948	Mandelate Racemase Muconate Lactonizing
DB847_RS10515	COG0697	spore germination
DB847_RS10520	COG2721	sulfolactate sulfo-lyase activity
DB847_RS10530	COG2186	Transcriptional regulator
DB847_RS10565	COG2814	Major facilitator Superfamily
DB847_RS10580	COG0747	negative chemotaxis
DB847_RS10590	COG0786	glutamate:sodium symporter activity
DB847_RS10595	COG2878	Part of a membrane complex involved in electron transport
DB847_RS10600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DB847_RS10620	COG1366	Belongs to the anti-sigma-factor antagonist family
DB847_RS10625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DB847_RS10655	COG0598	Magnesium transport protein CorA
DB847_RS10660	COG3300	MHYT domain
DB847_RS10660	COG5001	Diguanylate cyclase
DB847_RS10700	COG0443	Heat shock 70 kDa protein
DB847_RS10710	COG2314	TM2 domain
DB847_RS10720	COG1115	amino acid carrier protein
DB847_RS10730	COG1012	belongs to the aldehyde dehydrogenase family
DB847_RS10765	COG4160	amino acid transport
DB847_RS10770	COG4215	(ABC) transporter
DB847_RS10775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS10780	COG1126	abc transporter atp-binding protein
DB847_RS10795	COG1349	DNA-binding transcription factor activity
DB847_RS10800	COG1882	Formate acetyltransferase
DB847_RS10805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DB847_RS10840	COG3152	Membrane
DB847_RS10850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DB847_RS10860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DB847_RS10865	COG0477	Major facilitator Superfamily
DB847_RS10870	COG2814	Major facilitator Superfamily
DB847_RS10875	COG0791	NLP P60 protein
DB847_RS10875	COG1388	LysM domain
DB847_RS10890	COG0367	asparagine synthase
DB847_RS10895	COG0647	UMP catabolic process
DB847_RS10920	COG2818	Glycosylase
DB847_RS10930	COG1199	ATP-dependent helicase activity
DB847_RS10935	COG1214	PFAM Peptidase M22, glycoprotease
DB847_RS10965	COG0626	cystathionine gamma-synthase activity
DB847_RS10970	COG0583	DNA-binding transcription factor activity
DB847_RS10990	COG3979	chitinase
DB847_RS10995	COG3979	chitinase
DB847_RS11005	COG3469	chitinase activity
DB847_RS11015	COG1882	Formate acetyltransferase
DB847_RS11035	COG0735	belongs to the Fur family
DB847_RS11040	COG0469	pyruvate kinase activity
DB847_RS11045	COG1737	Transcriptional regulator
DB847_RS11070	COG1982	Orn Lys Arg decarboxylase major
DB847_RS11110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB847_RS11115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DB847_RS11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB847_RS11120	COG0072	phenylalanine-tRNA ligase activity
DB847_RS11125	COG0776	regulation of translation
DB847_RS11160	COG1177	transmembrane transport
DB847_RS11170	COG3842	ATPase activity
DB847_RS11175	COG2992	FlgJ-related protein
DB847_RS11225	COG0037	tRNA processing
DB847_RS11235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DB847_RS11240	COG1530	ribonuclease E activity
DB847_RS11245	COG0564	pseudouridine synthase activity
DB847_RS11250	COG0546	phosphoglycolate phosphatase activity
DB847_RS11275	COG0424	maF-like protein
DB847_RS11280	COG1399	metal-binding, possibly nucleic acid-binding protein
DB847_RS11285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DB847_RS11290	COG0416	fatty acid biosynthetic process
DB847_RS11300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DB847_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS11310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB847_RS11320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB847_RS11325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DB847_RS11330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DB847_RS11335	COG0470	DNA polymerase III
DB847_RS11345	COG0084	hydrolase, TatD family'
DB847_RS11355	COG3593	DNA synthesis involved in DNA repair
DB847_RS11390	COG4964	Belongs to the GSP D family
DB847_RS11450	COG2205	protein histidine kinase activity
DB847_RS11450	COG3437	response regulator, receiver
DB847_RS11450	COG3850	Histidine kinase
DB847_RS11450	COG4999	Histidine kinase
DB847_RS11460	COG2205	protein histidine kinase activity
DB847_RS11460	COG0784	Response regulator, receiver
DB847_RS11485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DB847_RS11490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DB847_RS11490	COG0617	tRNA 3'-terminal CCA addition
DB847_RS11490	COG0517	IMP dehydrogenase activity
DB847_RS11500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DB847_RS11520	COG5002	protein histidine kinase activity
DB847_RS11520	COG2205	protein histidine kinase activity
DB847_RS11520	COG0784	Response regulator, receiver
DB847_RS11525	COG5002	protein histidine kinase activity
DB847_RS11525	COG0784	Response regulator, receiver
DB847_RS11525	COG2205	protein histidine kinase activity
DB847_RS11565	COG3001	Fructosamine kinase
DB847_RS11580	COG1609	Transcriptional regulator
DB847_RS11665	COG2204	response regulator
DB847_RS11680	COG2801	Transposase and inactivated derivatives
DB847_RS11690	COG2801	Transposase and inactivated derivatives
DB847_RS11745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS11760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DB847_RS11780	COG2703	oxygen carrier activity
DB847_RS11800	COG0583	DNA-binding transcription factor activity
DB847_RS11805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DB847_RS11855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DB847_RS11860	COG1360	Flagellar Motor Protein
DB847_RS11875	COG5642	Protein of unknown function (DUF2384)
DB847_RS11880	COG5654	RES domain protein
DB847_RS11900	COG5642	Protein of unknown function (DUF2384)
DB847_RS11910	COG1067	ATP-dependent peptidase activity
DB847_RS11915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DB847_RS11920	COG1380	Effector of murein hydrolase LrgA
DB847_RS11930	COG0295	cytidine deaminase activity
DB847_RS11935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DB847_RS11935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DB847_RS11945	COG4974	Belongs to the 'phage' integrase family
DB847_RS11960	COG0346	lactoylglutathione lyase activity
DB847_RS11970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DB847_RS11985	COG0534	Mate efflux family protein
DB847_RS11990	COG1695	Transcriptional regulator
DB847_RS12010	COG1501	Belongs to the glycosyl hydrolase 31 family
DB847_RS12020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DB847_RS12025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DB847_RS12040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DB847_RS12095	COG4644	lycopene metabolic process
DB847_RS12105	COG0840	transmembrane signaling receptor activity
DB847_RS12115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DB847_RS12120	COG1263	PTS System
DB847_RS12120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS12125	COG0471	metal ion transport
DB847_RS12130	COG0679	Auxin Efflux Carrier
DB847_RS12155	COG0717	Belongs to the dCTP deaminase family
DB847_RS12160	COG0572	uridine kinase
DB847_RS12170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB847_RS12170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB847_RS12205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DB847_RS12210	COG1269	ATP hydrolysis coupled proton transport
DB847_RS12230	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DB847_RS12240	COG1394	ATPase activity, coupled to movement of substances
DB847_RS12265	COG2249	NAD(P)H dehydrogenase (quinone) activity
DB847_RS12270	COG0583	DNA-binding transcription factor activity
DB847_RS12315	COG0569	domain protein
DB847_RS12320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DB847_RS12325	COG0745	RESPONSE REGULATOR receiver
DB847_RS12355	COG0784	Response regulator, receiver
DB847_RS12355	COG5002	protein histidine kinase activity
DB847_RS12355	COG2205	protein histidine kinase activity
DB847_RS12360	COG4999	Histidine kinase
DB847_RS12360	COG3850	Histidine kinase
DB847_RS12360	COG2205	protein histidine kinase activity
DB847_RS12360	COG3437	response regulator, receiver
DB847_RS12380	COG0346	lactoylglutathione lyase activity
DB847_RS12390	COG2197	response regulator
DB847_RS12395	COG5002	protein histidine kinase activity
DB847_RS12395	COG2205	protein histidine kinase activity
DB847_RS12395	COG0784	Response regulator, receiver
DB847_RS12405	COG0814	amino acid
DB847_RS12415	COG1448	Aminotransferase
DB847_RS12420	COG2925	Exonuclease
DB847_RS12480	COG3706	GGDEF domain
DB847_RS12490	COG2095	MarC family integral membrane protein
DB847_RS12495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DB847_RS12500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DB847_RS12510	COG0205	6-phosphofructokinase activity
DB847_RS12520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DB847_RS12520	COG0519	Catalyzes the synthesis of GMP from XMP
DB847_RS12545	COG3188	usher protein
DB847_RS12560	COG0768	penicillin binding
DB847_RS12570	COG2926	Belongs to the UPF0265 family
DB847_RS12575	COG3530	Putative quorum-sensing-regulated virulence factor
DB847_RS12595	COG2095	MarC family integral membrane protein
DB847_RS12605	COG0488	(ABC) transporter
DB847_RS12625	COG1757	Na H antiporter
DB847_RS12650	COG2771	luxR family
DB847_RS12665	COG4584	PFAM Integrase catalytic
DB847_RS12670	COG1484	DNA-dependent DNA replication
DB847_RS12675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DB847_RS12685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS12690	COG2223	nitrite transmembrane transporter activity
DB847_RS12700	COG3111	PFAM Bacterial OB fold (BOF) protein
DB847_RS12710	COG3437	response regulator, receiver
DB847_RS12710	COG0784	Response regulator, receiver
DB847_RS12730	COG3209	COG3209 Rhs family protein
DB847_RS12740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DB847_RS12745	COG2890	protein-(glutamine-N5) methyltransferase activity
DB847_RS12755	COG0583	DNA-binding transcription factor activity
DB847_RS12760	COG0583	DNA-binding transcription factor activity
DB847_RS12820	COG2068	MobA-Related Protein
DB847_RS12825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DB847_RS12850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DB847_RS12860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB847_RS12870	COG0549	Belongs to the carbamate kinase family
DB847_RS12880	COG1013	pyruvate-flavodoxin oxidoreductase activity
DB847_RS12880	COG0674	pyruvate-flavodoxin oxidoreductase activity
DB847_RS12880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DB847_RS12880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DB847_RS12885	COG1797	cobyrinic acid a,c-diamide synthase activity
DB847_RS12890	COG2363	Small membrane protein
DB847_RS12915	COG0840	transmembrane signaling receptor activity
DB847_RS12940	COG3962	Belongs to the TPP enzyme family
DB847_RS12945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS12965	COG0673	inositol 2-dehydrogenase activity
DB847_RS12970	COG2814	Major facilitator Superfamily
DB847_RS12980	COG2373	Large extracellular alpha-helical protein
DB847_RS12980	COG4932	domain protein
DB847_RS12980	COG1388	LysM domain
DB847_RS13015	COG0745	RESPONSE REGULATOR receiver
DB847_RS13020	COG2205	protein histidine kinase activity
DB847_RS13025	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DB847_RS13040	COG0668	transmembrane transport
DB847_RS13045	COG2999	glutathione oxidoreductase activity
DB847_RS13050	COG1560	Kdo2-lipid A biosynthetic process
DB847_RS13065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB847_RS13065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB847_RS13070	COG1619	proteins homologs of microcin C7 resistance protein MccF
DB847_RS13080	COG0814	amino acid
DB847_RS13085	COG1760	l-serine dehydratase
DB847_RS13090	COG0814	amino acid
DB847_RS13100	COG0493	'glutamate synthase
DB847_RS13120	COG2814	Major facilitator Superfamily
DB847_RS13130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB847_RS13130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DB847_RS13135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB847_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS13170	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB847_RS13175	COG1486	melibiose metabolic process
DB847_RS13180	COG1609	Transcriptional regulator
DB847_RS13195	COG2233	PERMEase
DB847_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS13225	COG3426	butyrate kinase activity
DB847_RS13230	COG0280	phosphate acetyltransferase
DB847_RS13235	COG0183	Belongs to the thiolase family
DB847_RS13245	COG0745	RESPONSE REGULATOR receiver
DB847_RS13265	COG0745	RESPONSE REGULATOR receiver
DB847_RS13270	COG3850	Histidine kinase
DB847_RS13270	COG5002	protein histidine kinase activity
DB847_RS13320	COG3153	acetyltransferase
DB847_RS13335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB847_RS13340	COG1121	(ABC) transporter
DB847_RS13350	COG2824	Alkylphosphonate utilization operon protein PhnA
DB847_RS13355	COG0730	response to heat
DB847_RS13360	COG0583	DNA-binding transcription factor activity
DB847_RS13370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DB847_RS13370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DB847_RS13400	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DB847_RS13415	COG3132	Protein of unknown function, DUF480
DB847_RS13425	COG2990	Protein conserved in bacteria
DB847_RS13440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DB847_RS13465	COG0658	competence protein
DB847_RS13465	COG2333	competence protein COMEC
DB847_RS13485	COG1960	acyl-CoA dehydrogenase activity
DB847_RS13490	COG1024	Enoyl-CoA hydratase
DB847_RS13490	COG1250	3-hydroxyacyl-CoA dehydrogenase
DB847_RS13500	COG0318	PFAM AMP-dependent synthetase and ligase
DB847_RS13525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DB847_RS13535	COG4591	ABC-type transport system involved in lipoprotein release permease component
DB847_RS13540	COG1136	(ABC) transporter
DB847_RS13545	COG4591	ABC-type transport system involved in lipoprotein release permease component
DB847_RS13565	COG2056	Na+-H+ antiporter family
DB847_RS13595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DB847_RS13605	COG0560	Phosphoserine phosphatase
DB847_RS13620	COG1335	isochorismatase
DB847_RS13650	COG1247	-acetyltransferase
DB847_RS13675	COG0300	oxidoreductase activity
DB847_RS13715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DB847_RS13730	COG2197	response regulator
DB847_RS13765	COG2252	PERMEase
DB847_RS13860	COG4584	PFAM Integrase catalytic
DB847_RS13865	COG1484	DNA-dependent DNA replication
DB847_RS13940	COG1484	DNA-dependent DNA replication
DB847_RS13960	COG2176	DNA-directed DNA polymerase activity
DB847_RS13995	COG0582	viral genome integration into host DNA
DB847_RS14005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DB847_RS14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS14020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DB847_RS14050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS14055	COG0709	Synthesizes selenophosphate from selenide and ATP
DB847_RS14060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DB847_RS14065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB847_RS14075	COG2501	S4 domain
DB847_RS14080	COG0653	protein targeting
DB847_RS14095	COG0739	heme binding
DB847_RS14120	COG0628	permease
DB847_RS14135	COG2816	NAD+ diphosphatase activity
DB847_RS14140	COG0095	Lipoate-protein ligase
DB847_RS14140	COG3726	membrane protein affecting hemolysin expression
DB847_RS14180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DB847_RS14185	COG1286	toxin biosynthetic process
DB847_RS14200	COG0322	excinuclease ABC activity
DB847_RS14205	COG2197	response regulator
DB847_RS14210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DB847_RS14215	COG0776	regulation of translation
DB847_RS14220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DB847_RS14230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DB847_RS14280	COG0583	DNA-binding transcription factor activity
DB847_RS14305	COG0537	adenosine 5'-monophosphoramidase activity
DB847_RS14315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DB847_RS14330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DB847_RS14335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DB847_RS14340	COG1845	cytochrome c oxidase, subunit III
DB847_RS14345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DB847_RS14350	COG0109	protoheme IX farnesyltransferase activity
DB847_RS14355	COG2814	Major facilitator Superfamily
DB847_RS14360	COG0730	response to heat
DB847_RS14440	COG1484	DNA-dependent DNA replication
DB847_RS14535	COG3976	FMN-binding domain protein
DB847_RS14535	COG0431	NADPH-dependent FMN reductase
DB847_RS14535	COG1053	succinate dehydrogenase
DB847_RS14550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DB847_RS14555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DB847_RS14560	COG0367	asparagine synthase
DB847_RS14580	COG0784	Response regulator, receiver
DB847_RS14580	COG2205	protein histidine kinase activity
DB847_RS14610	COG0583	DNA-binding transcription factor activity
DB847_RS14620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB847_RS14620	COG0072	phenylalanine-tRNA ligase activity
DB847_RS14640	COG1741	Belongs to the pirin family
DB847_RS14645	COG0435	Glutathione S-transferase
DB847_RS14655	COG1956	GAF domain-containing protein
DB847_RS14660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DB847_RS14685	COG2916	Histone family protein nucleoid-structuring protein H-NS
DB847_RS14705	COG0004	ammonium transporteR
DB847_RS14715	COG3623	hexulose-6-phosphate isomerase
DB847_RS14740	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DB847_RS14750	COG0318	PFAM AMP-dependent synthetase and ligase
DB847_RS14750	COG0204	Acyl-transferase
DB847_RS14755	COG2832	Protein of unknown function (DUF454)
DB847_RS14770	COG2814	Major facilitator Superfamily
DB847_RS14805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB847_RS14850	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DB847_RS14855	COG0247	lactate metabolic process
DB847_RS14875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS14875	COG1522	sequence-specific DNA binding
DB847_RS14880	COG0659	secondary active sulfate transmembrane transporter activity
DB847_RS14885	COG1280	lysine exporter protein (LysE YggA)
DB847_RS14890	COG1435	thymidine kinase activity
DB847_RS14895	COG2814	Major facilitator Superfamily
DB847_RS14905	COG0583	DNA-binding transcription factor activity
DB847_RS14915	COG2814	Major facilitator Superfamily
DB847_RS14920	COG2096	Adenosyltransferase
DB847_RS14925	COG0602	queuosine metabolic process
DB847_RS14940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DB847_RS14945	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DB847_RS14950	COG0776	regulation of translation
DB847_RS14955	COG0539	negative regulation of cytoplasmic translation
DB847_RS14965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS14965	COG0674	pyruvate-flavodoxin oxidoreductase activity
DB847_RS14965	COG1013	pyruvate-flavodoxin oxidoreductase activity
DB847_RS14965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DB847_RS14970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DB847_RS14980	COG0076	glutamate decarboxylase activity
DB847_RS15000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DB847_RS15005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DB847_RS15010	COG1199	ATP-dependent helicase activity
DB847_RS15035	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DB847_RS15040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS15050	COG2194	sulfuric ester hydrolase activity
DB847_RS15055	COG0778	Nitroreductase
DB847_RS15060	COG1714	RDD family
DB847_RS15065	COG0393	Putative heavy-metal-binding
DB847_RS15070	COG0519	Catalyzes the synthesis of GMP from XMP
DB847_RS15070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DB847_RS15075	COG0516	GMP reductase activity
DB847_RS15075	COG0517	IMP dehydrogenase activity
DB847_RS15100	COG0622	Phosphoesterase
DB847_RS15125	COG0545	Peptidyl-prolyl cis-trans isomerase
DB847_RS15130	COG3142	Participates in the control of copper homeostasis
DB847_RS15160	COG1472	Belongs to the glycosyl hydrolase 3 family
DB847_RS15165	COG0583	DNA-binding transcription factor activity
DB847_RS15175	COG2199	diguanylate cyclase activity
DB847_RS15185	COG1538	Outer membrane efflux protein
DB847_RS15210	COG1940	carbohydrate kinase activity
DB847_RS15215	COG0569	domain protein
DB847_RS15215	COG2985	domain, Protein
DB847_RS15235	COG0714	Associated with various cellular activities
DB847_RS15255	COG2304	oxidoreductase activity
DB847_RS15275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS15280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DB847_RS15305	COG0590	tRNA wobble adenosine to inosine editing
DB847_RS15315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS15320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS15325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS15325	COG0649	NAD binding
DB847_RS15330	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DB847_RS15335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DB847_RS15340	COG1034	ATP synthesis coupled electron transport
DB847_RS15345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DB847_RS15350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS15365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DB847_RS15370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB847_RS15375	COG1007	ATP synthesis coupled electron transport
DB847_RS15400	COG1484	DNA-dependent DNA replication
DB847_RS15405	COG4584	PFAM Integrase catalytic
DB847_RS15420	COG2165	general secretion pathway protein
DB847_RS15445	COG0583	DNA-binding transcription factor activity
DB847_RS15450	COG2814	Major facilitator Superfamily
DB847_RS15465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS15465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DB847_RS15470	COG0564	pseudouridine synthase activity
DB847_RS15480	COG0670	Belongs to the BI1 family
DB847_RS15485	COG0028	Belongs to the TPP enzyme family
DB847_RS15495	COG1289	transmembrane transporter activity
DB847_RS15500	COG2920	part of a sulfur-relay system
DB847_RS15510	COG4584	PFAM Integrase catalytic
DB847_RS15515	COG1484	DNA-dependent DNA replication
DB847_RS15535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DB847_RS15540	COG0101	tRNA pseudouridine synthase activity
DB847_RS15550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DB847_RS15555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB847_RS15560	COG0671	phosphoesterase, PA-phosphatase related
DB847_RS15565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DB847_RS15570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DB847_RS15570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB847_RS15580	COG0737	Belongs to the 5'-nucleotidase family
DB847_RS15610	COG0366	Alpha amylase catalytic
DB847_RS15620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DB847_RS15630	COG0076	glutamate decarboxylase activity
DB847_RS15650	COG0346	lactoylglutathione lyase activity
DB847_RS15670	COG1968	undecaprenyl-diphosphatase activity
DB847_RS15675	COG3437	response regulator, receiver
DB847_RS15675	COG0784	Response regulator, receiver
DB847_RS15700	COG2991	Protein conserved in bacteria
DB847_RS15705	COG1477	protein flavinylation
DB847_RS15715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DB847_RS15720	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DB847_RS15725	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DB847_RS15735	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DB847_RS15740	COG0271	Belongs to the BolA IbaG family
DB847_RS15745	COG2813	Specifically methylates the guanine in position
DB847_RS15755	COG2211	Major facilitator Superfamily
DB847_RS15780	COG3710	Transcriptional regulator
DB847_RS15780	COG0457	Tetratricopeptide repeat
DB847_RS15790	COG1426	Protein conserved in bacteria
DB847_RS15800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DB847_RS15845	COG0728	peptidoglycan biosynthetic process
DB847_RS15865	COG0105	UTP biosynthetic process
DB847_RS15875	COG2975	iron-sulfur cluster assembly
DB847_RS15880	COG0633	Ferredoxin
DB847_RS15890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DB847_RS15900	COG0822	iron-sulfur transferase activity
DB847_RS15905	COG1104	cysteine desulfurase activity
DB847_RS15910	COG1959	2 iron, 2 sulfur cluster binding
DB847_RS15925	COG3154	lipid carrier protein
DB847_RS15930	COG0826	peptidase U32
DB847_RS15935	COG0826	peptidase U32
DB847_RS15940	COG4584	PFAM Integrase catalytic
DB847_RS15945	COG1484	DNA-dependent DNA replication
DB847_RS15980	COG2814	Major facilitator Superfamily
DB847_RS15985	COG1566	PFAM secretion protein HlyD family protein
DB847_RS16005	COG1054	Belongs to the UPF0176 family
DB847_RS16010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB847_RS16015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB847_RS16020	COG1862	Preprotein translocase
DB847_RS16030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DB847_RS16055	COG1621	beta-fructofuranosidase activity
DB847_RS16090	COG0583	DNA-binding transcription factor activity
DB847_RS16095	COG0450	alkyl hydroperoxide reductase
DB847_RS16215	COG1011	Hydrolase
DB847_RS16220	COG3081	Nucleoid-associated protein
DB847_RS16225	COG3082	Protein of unknown function (DUF1414)
DB847_RS16240	COG4176	ABC-type proline glycine betaine transport system permease component
DB847_RS16245	COG1116	anion transmembrane transporter activity
DB847_RS16260	COG2226	methyltransferase
DB847_RS16265	COG0297	glycogen (starch) synthase activity
DB847_RS16265	COG0438	transferase activity, transferring glycosyl groups
DB847_RS16275	COG1683	Conserved Protein
DB847_RS16280	COG0494	nUDIX hydrolase
DB847_RS16300	COG0586	Pfam SNARE associated Golgi protein
DB847_RS16310	COG0456	acetyltransferase
DB847_RS16315	COG0747	negative chemotaxis
DB847_RS16340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB847_RS16340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB847_RS16345	COG0509	glycine decarboxylation via glycine cleavage system
DB847_RS16350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DB847_RS16355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB847_RS16360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB847_RS16365	COG0745	RESPONSE REGULATOR receiver
DB847_RS16395	COG4977	sequence-specific DNA binding
DB847_RS16400	COG0708	Exodeoxyribonuclease III
DB847_RS16405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB847_RS16415	COG1473	amidohydrolase
DB847_RS16420	COG1944	ATP diphosphatase activity
DB847_RS16450	COG3141	response to X-ray
DB847_RS16455	COG1032	radical SAM domain protein
DB847_RS16465	COG0583	DNA-binding transcription factor activity
DB847_RS16485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DB847_RS16490	COG1882	Formate acetyltransferase
DB847_RS16495	COG3092	negative regulation of chromosome organization
DB847_RS16505	COG0280	phosphate acetyltransferase
DB847_RS16505	COG0857	belongs to the CobB CobQ family
DB847_RS16525	COG1090	epimerase
DB847_RS16535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS16535	COG1263	PTS System
DB847_RS16540	COG1263	PTS System
DB847_RS16540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB847_RS16555	COG0252	asparaginase activity
DB847_RS16560	COG2197	response regulator
DB847_RS16570	COG2271	Major facilitator Superfamily
DB847_RS16580	COG2271	Major facilitator Superfamily
DB847_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS16610	COG0126	phosphoglycerate kinase activity
DB847_RS16615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DB847_RS16620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DB847_RS16630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DB847_RS16660	COG0513	Belongs to the DEAD box helicase family
DB847_RS16665	COG4807	Protein conserved in bacteria
DB847_RS16670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DB847_RS16680	COG0513	Belongs to the DEAD box helicase family
DB847_RS16685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DB847_RS16690	COG0189	ligase activity
DB847_RS16695	COG1678	Uncharacterized ACR, COG1678
DB847_RS16700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DB847_RS16705	COG3093	addiction module antidote protein HigA
DB847_RS16715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB847_RS16720	COG0616	signal peptide processing
DB847_RS16725	COG1645	bacterial-type flagellum-dependent swarming motility
DB847_RS16730	COG1160	GTP binding
DB847_RS16735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB847_RS16740	COG2976	Protein conserved in bacteria
DB847_RS16745	COG0124	histidyl-tRNA synthetase
DB847_RS16755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS16765	COG2207	Transcriptional regulator
DB847_RS16770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS16770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS16785	COG0671	phosphoesterase, PA-phosphatase related
DB847_RS16790	COG1227	inorganic diphosphatase activity
DB847_RS16795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DB847_RS16820	COG1605	Chorismate mutase
DB847_RS16820	COG0287	Prephenate dehydrogenase
DB847_RS16825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DB847_RS16835	COG0039	L-malate dehydrogenase activity
DB847_RS16850	COG0436	Aminotransferase
DB847_RS16855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DB847_RS16860	COG3013	Belongs to the UPF0304 family
DB847_RS16890	COG2205	protein histidine kinase activity
DB847_RS16895	COG2205	protein histidine kinase activity
DB847_RS16900	COG0745	RESPONSE REGULATOR receiver
DB847_RS16915	COG1289	transmembrane transporter activity
DB847_RS16920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB847_RS16925	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
DB847_RS16930	COG2217	Heavy metal translocating P-type atpase
DB847_RS16935	COG2226	methyltransferase
DB847_RS16950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DB847_RS16955	COG0083	homoserine kinase activity
DB847_RS16965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DB847_RS16975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DB847_RS16995	COG0745	RESPONSE REGULATOR receiver
DB847_RS17015	COG4988	ABC transporter
DB847_RS17020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DB847_RS17025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DB847_RS17035	COG1595	DNA-templated transcription, initiation
DB847_RS17050	COG4221	oxidoreductase activity
DB847_RS17055	COG1115	amino acid carrier protein
DB847_RS17060	COG4166	transmembrane transport
DB847_RS17065	COG0531	amino acid
DB847_RS17070	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DB847_RS17085	COG3275	phosphorelay sensor kinase activity
DB847_RS17090	COG3279	Response regulator of the LytR AlgR family
DB847_RS17105	COG2223	nitrite transmembrane transporter activity
DB847_RS17130	COG1720	tRNA m6t6A37 methyltransferase activity
DB847_RS17150	COG1162	GTPase activity
DB847_RS17160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DB847_RS17195	COG1131	(ABC) transporter
DB847_RS17215	COG0589	response to stress
DB847_RS17220	COG3789	protein conserved in bacteria
DB847_RS17225	COG1842	Phage shock protein A
DB847_RS17305	COG0156	8-amino-7-oxononanoate synthase activity
DB847_RS17320	COG2723	6-phospho-beta-galactosidase activity
DB847_RS17325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB847_RS17335	COG1609	Transcriptional regulator
DB847_RS17340	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB847_RS17345	COG1151	hydroxylamine reductase activity
DB847_RS17350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DB847_RS17355	COG0318	PFAM AMP-dependent synthetase and ligase
DB847_RS17370	COG2095	MarC family integral membrane protein
DB847_RS17385	COG0814	amino acid
DB847_RS17405	COG2188	Transcriptional regulator
DB847_RS17430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DB847_RS17435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DB847_RS17445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB847_RS17455	COG2207	Transcriptional regulator
DB847_RS17460	COG1979	alcohol dehydrogenase
DB847_RS17465	COG2814	Major facilitator Superfamily
DB847_RS17470	COG0842	Transport permease protein
DB847_RS17475	COG1131	(ABC) transporter
DB847_RS17495	COG0110	maltose O-acetyltransferase activity
DB847_RS17500	COG0497	DNA recombination
DB847_RS17505	COG1770	oligopeptidase
DB847_RS17520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DB847_RS17520	COG0301	tRNA thio-modification
DB847_RS17530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DB847_RS17535	COG1722	exodeoxyribonuclease VII activity
DB847_RS17540	COG0142	geranyltranstransferase activity
DB847_RS17545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DB847_RS17600	COG1304	FMN binding
DB847_RS17605	COG3604	Transcriptional regulator
DB847_RS17635	COG0179	Fumarylacetoacetate (FAA) hydrolase
DB847_RS17690	COG0456	acetyltransferase
DB847_RS17810	COG0784	Response regulator, receiver
DB847_RS17810	COG2205	protein histidine kinase activity
DB847_RS17810	COG2198	Histidine kinase
DB847_RS17815	COG2197	response regulator
DB847_RS17820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DB847_RS17835	COG0066	3-isopropylmalate dehydratase activity
DB847_RS17845	COG0738	Major facilitator superfamily
DB847_RS17880	COG0163	prenyltransferase activity
DB847_RS17895	COG2205	protein histidine kinase activity
DB847_RS17895	COG0784	Response regulator, receiver
DB847_RS17925	COG1242	4 iron, 4 sulfur cluster binding
DB847_RS17945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DB847_RS17955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB847_RS17980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DB847_RS17985	COG0739	heme binding
DB847_RS18010	COG2233	PERMEase
DB847_RS18045	COG0316	Belongs to the HesB IscA family
DB847_RS18055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DB847_RS18060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DB847_RS18070	COG4584	PFAM Integrase catalytic
DB847_RS18075	COG1484	DNA-dependent DNA replication
DB847_RS18125	COG0116	Belongs to the methyltransferase superfamily
DB847_RS18125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DB847_RS18140	COG1484	DNA-dependent DNA replication
DB847_RS18145	COG4584	PFAM Integrase catalytic
DB847_RS18160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DB847_RS18190	COG1523	belongs to the glycosyl hydrolase 13 family
DB847_RS18205	COG2207	Transcriptional regulator
DB847_RS18215	COG0477	Major facilitator Superfamily
DB847_RS18245	COG1401	restriction endodeoxyribonuclease activity
DB847_RS18305	COG3104	oligopeptide transport
DB847_RS18325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB847_RS18330	COG0601	transmembrane transport
DB847_RS18340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DB847_RS18350	COG1309	transcriptional regulator
DB847_RS18355	COG2130	NADP-dependent
DB847_RS18365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB847_RS18390	COG2226	methyltransferase
DB847_RS18435	COG1609	Transcriptional regulator
DB847_RS18445	COG0129	dihydroxy-acid dehydratase activity
DB847_RS18450	COG3265	gluconokinase activity
DB847_RS18455	COG2610	gluconate transmembrane transporter activity
DB847_RS18480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DB847_RS18485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DB847_RS18490	COG2264	protein methyltransferase activity
DB847_RS18530	COG1126	abc transporter atp-binding protein
DB847_RS18545	COG0583	DNA-binding transcription factor activity
DB847_RS18570	COG0439	Biotin carboxylase
DB847_RS18575	COG0511	ligase activity, forming carbon-carbon bonds
DB847_RS18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS18605	COG0825	malonyl-CoA metabolic process
DB847_RS18615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DB847_RS18620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB847_RS18625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB847_RS18630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DB847_RS18635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB847_RS18640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DB847_RS18645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB847_RS18655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DB847_RS18660	COG0575	Belongs to the CDS family
DB847_RS18665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DB847_RS18670	COG0233	cytoplasmic translational termination
DB847_RS18675	COG0528	UMP kinase activity
DB847_RS18680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DB847_RS18685	COG0052	Belongs to the universal ribosomal protein uS2 family
DB847_RS18695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DB847_RS18715	COG0564	pseudouridine synthase activity
DB847_RS18720	COG3098	single-species biofilm formation
DB847_RS18740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB847_RS18740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB847_RS18760	COG0473	3-isopropylmalate dehydrogenase activity
DB847_RS18765	COG0387	Pfam Sodium calcium exchanger
DB847_RS18770	COG0069	glutamate synthase activity
DB847_RS18795	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DB847_RS18800	COG0583	DNA-binding transcription factor activity
DB847_RS18805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DB847_RS18820	COG4689	acetoacetate decarboxylase
DB847_RS18830	COG1454	alcohol dehydrogenase
DB847_RS18845	COG2912	Transglutaminase-like superfamily
DB847_RS18855	COG2890	protein-(glutamine-N5) methyltransferase activity
DB847_RS18860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DB847_RS18865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DB847_RS18870	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DB847_RS18875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DB847_RS18880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DB847_RS18890	COG3104	oligopeptide transport
DB847_RS18905	COG0193	aminoacyl-tRNA hydrolase activity
DB847_RS18910	COG0012	GTP binding
DB847_RS18920	COG4191	Histidine kinase
DB847_RS18920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS18925	COG3104	oligopeptide transport
DB847_RS18930	COG4191	Histidine kinase
DB847_RS18930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS18970	COG1879	ABC-type sugar transport system periplasmic component
DB847_RS18995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB847_RS19000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB847_RS19005	COG1702	phosphate starvation-inducible protein PhoH
DB847_RS19010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DB847_RS19015	COG4535	Mg2 and Co2 transporter CorC
DB847_RS19020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DB847_RS19025	COG4191	Histidine kinase
DB847_RS19030	COG4191	Histidine kinase
DB847_RS19060	COG0495	leucyl-tRNA aminoacylation
DB847_RS19070	COG1466	dna polymerase III delta subunit
DB847_RS19075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DB847_RS19080	COG0799	negative regulation of ribosome biogenesis
DB847_RS19085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DB847_RS19090	COG0768	penicillin binding
DB847_RS19095	COG0772	Belongs to the SEDS family
DB847_RS19100	COG2951	lytic endotransglycosylase activity
DB847_RS19105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DB847_RS19110	COG1686	Belongs to the peptidase S11 family
DB847_RS19120	COG2921	Belongs to the UPF0250 family
DB847_RS19125	COG0321	lipoyl(octanoyl) transferase activity
DB847_RS19130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DB847_RS19150	COG0642	Histidine kinase
DB847_RS19155	COG0745	RESPONSE REGULATOR receiver
DB847_RS19160	COG3111	PFAM Bacterial OB fold (BOF) protein
DB847_RS19165	COG0516	GMP reductase activity
DB847_RS19165	COG0517	IMP dehydrogenase activity
DB847_RS19175	COG4178	(ABC) transporter
DB847_RS19190	COG4143	(ABC) transporter
DB847_RS19195	COG1178	ABC-type Fe3 transport system permease component
DB847_RS19200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DB847_RS19240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DB847_RS19260	COG0488	(ABC) transporter
DB847_RS19295	COG1609	Transcriptional regulator
DB847_RS19300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS19320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB847_RS19335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DB847_RS19390	COG4584	PFAM Integrase catalytic
DB847_RS19395	COG1484	DNA-dependent DNA replication
DB847_RS19440	COG2165	general secretion pathway protein
DB847_RS19450	COG3150	esterase
DB847_RS19455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DB847_RS19460	COG0494	nUDIX hydrolase
DB847_RS19465	COG1538	Outer membrane efflux protein
DB847_RS19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB847_RS19475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DB847_RS19500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DB847_RS19505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DB847_RS19510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DB847_RS19520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DB847_RS19525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DB847_RS19530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DB847_RS19535	COG1592	Rubrerythrin
DB847_RS19550	COG2966	Psort location CytoplasmicMembrane, score
DB847_RS19555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DB847_RS19565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DB847_RS19570	COG0142	geranyltranstransferase activity
DB847_RS19575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DB847_RS19580	COG0330	HflC and HflK could
DB847_RS19585	COG0330	HflC and HflK could
DB847_RS19590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DB847_RS19595	COG1923	regulation of RNA biosynthetic process
DB847_RS19600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DB847_RS19605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DB847_RS19610	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB847_RS19615	COG0802	atpase or kinase
DB847_RS19625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DB847_RS19660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DB847_RS19665	COG1162	GTPase activity
DB847_RS19670	COG0688	phosphatidylethanolamine metabolic process
DB847_RS19675	COG0471	metal ion transport
DB847_RS19690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DB847_RS19695	COG1053	succinate dehydrogenase
DB847_RS19700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DB847_RS19710	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DB847_RS19715	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
DB847_RS19720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DB847_RS19725	COG1509	lysine 2,3-aminomutase activity
DB847_RS19750	COG3138	arginine N-succinyltransferase
DB847_RS19775	COG1392	Phosphate transport regulator
DB847_RS19780	COG0306	phosphate transporter
DB847_RS19785	COG4991	sh3 domain protein
DB847_RS19820	COG4191	Histidine kinase
DB847_RS19820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS19840	COG3409	Peptidoglycan-binding domain 1 protein
DB847_RS19840	COG3267	Type II secretory pathway component ExeA
DB847_RS19855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DB847_RS19860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DB847_RS19880	COG1610	YqeY-like protein
DB847_RS19905	COG3284	Transcriptional regulator
DB847_RS19910	COG3284	Transcriptional regulator
DB847_RS19920	COG1461	Dihydroxyacetone kinase
DB847_RS19925	COG2376	Dihydroxyacetone kinase
DB847_RS19935	COG3718	enzyme involved in inositol metabolism
DB847_RS19965	COG1047	Peptidyl-prolyl cis-trans
DB847_RS19975	COG4176	ABC-type proline glycine betaine transport system permease component
DB847_RS19980	COG4175	Glycine betaine
DB847_RS19980	COG3448	diguanylate cyclase activity
DB847_RS19985	COG0814	amino acid
DB847_RS19990	COG0215	cysteine-tRNA ligase activity
DB847_RS20025	COG0795	lipopolysaccharide-transporting ATPase activity
DB847_RS20030	COG0795	lipopolysaccharide-transporting ATPase activity
DB847_RS20035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DB847_RS20040	COG2927	DNA polymerase III (CHI subunit)
DB847_RS20050	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
DB847_RS20085	COG2814	Major facilitator Superfamily
DB847_RS20105	COG1484	DNA-dependent DNA replication
DB847_RS20150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DB847_RS20170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DB847_RS20180	COG1105	Belongs to the carbohydrate kinase PfkB family
DB847_RS20195	COG0681	Belongs to the peptidase S26 family
DB847_RS20245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DB847_RS20270	COG0745	RESPONSE REGULATOR receiver
DB847_RS20285	COG0546	phosphoglycolate phosphatase activity
DB847_RS20290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DB847_RS20295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DB847_RS20305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DB847_RS20310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DB847_RS20340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DB847_RS20345	COG0305	Participates in initiation and elongation during chromosome replication
DB847_RS20350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DB847_RS20355	COG0432	Pfam Uncharacterised protein family UPF0047
DB847_RS20370	COG2095	MarC family integral membrane protein
DB847_RS20380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DB847_RS20390	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DB847_RS20395	COG5016	pyruvate
DB847_RS20395	COG0511	ligase activity, forming carbon-carbon bonds
DB847_RS20440	COG0527	aspartate kinase activity
DB847_RS20445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DB847_RS20450	COG2137	regulation of response to DNA damage stimulus
DB847_RS20455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DB847_RS20475	COG1929	Belongs to the glycerate kinase type-1 family
DB847_RS20485	COG3835	regulator
DB847_RS20490	COG1438	arginine binding
DB847_RS20495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DB847_RS20510	COG1012	belongs to the aldehyde dehydrogenase family
DB847_RS20520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DB847_RS20530	COG1238	metal cluster binding
DB847_RS20535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DB847_RS20540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DB847_RS20545	COG0585	pseudouridine synthase activity
DB847_RS20555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DB847_RS20560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DB847_RS20565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DB847_RS20570	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DB847_RS20575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DB847_RS20580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB847_RS20610	COG1846	Transcriptional regulator
DB847_RS20610	COG0456	acetyltransferase
DB847_RS20655	COG5001	Diguanylate cyclase
DB847_RS20655	COG4251	negative regulation of phosphorylation
DB847_RS20655	COG3706	GGDEF domain
DB847_RS20655	COG2203	Gaf domain
DB847_RS20670	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DB847_RS20675	COG1438	arginine binding
DB847_RS20685	COG1288	antiporter activity
DB847_RS20690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DB847_RS20705	COG3706	GGDEF domain
DB847_RS20730	COG0531	amino acid
DB847_RS20775	COG2807	transmembrane transport
DB847_RS20780	COG2207	Transcriptional regulator
DB847_RS20785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DB847_RS20790	COG1047	Peptidyl-prolyl cis-trans
DB847_RS20795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DB847_RS20800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DB847_RS20810	COG0196	riboflavin kinase activity
DB847_RS20815	COG0728	peptidoglycan biosynthetic process
DB847_RS20820	COG0268	Binds directly to 16S ribosomal RNA
DB847_RS20825	COG0640	Transcriptional regulator
DB847_RS20830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DB847_RS20835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DB847_RS20840	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
DB847_RS20845	COG1051	belongs to the nudix hydrolase family
DB847_RS20850	COG3066	DNA modification
DB847_RS20860	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DB847_RS20865	COG4536	flavin adenine dinucleotide binding
DB847_RS20870	COG4137	Cytochrome C assembly protein
DB847_RS20875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DB847_RS20880	COG0228	four-way junction DNA binding
DB847_RS20885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DB847_RS20895	COG0335	large ribosomal subunit rRNA binding
DB847_RS20910	COG0789	Transcriptional regulator
DB847_RS20925	COG1484	DNA-dependent DNA replication
DB847_RS20930	COG4584	PFAM Integrase catalytic
DB847_RS20945	COG1803	Methylglyoxal synthase
DB847_RS20950	COG2964	Protein conserved in bacteria
DB847_RS20955	COG0251	oxidation-reduction process
DB847_RS20960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DB847_RS20965	COG2923	Belongs to the DsrF TusC family
DB847_RS20980	COG0049	tRNA binding
DB847_RS21000	COG2194	sulfuric ester hydrolase activity
DB847_RS21005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DB847_RS21020	COG0360	Binds together with S18 to 16S ribosomal RNA
DB847_RS21025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DB847_RS21035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DB847_RS21040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS21045	COG2918	glutathione biosynthetic process
DB847_RS21060	COG0583	DNA-binding transcription factor activity
DB847_RS21070	COG0519	Catalyzes the synthesis of GMP from XMP
DB847_RS21085	COG0784	Response regulator, receiver
DB847_RS21085	COG5002	protein histidine kinase activity
DB847_RS21085	COG2198	Histidine kinase
DB847_RS21100	COG1127	ABC transporter
DB847_RS21105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DB847_RS21110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DB847_RS21115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DB847_RS21135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DB847_RS21140	COG0557	exoribonuclease II activity
DB847_RS21180	COG0724	RNA recognition motif
DB847_RS21185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DB847_RS21205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DB847_RS21210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS21215	COG0254	rRNA binding
DB847_RS21220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DB847_RS21240	COG2211	Major facilitator Superfamily
DB847_RS21240	COG2190	(PTS) system
DB847_RS21245	COG1609	Transcriptional regulator
DB847_RS21250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DB847_RS21255	COG1085	galactose-1-phosphate uridylyltransferase
DB847_RS21265	COG2017	converts alpha-aldose to the beta-anomer
DB847_RS21270	COG0018	arginyl-trna synthetase
DB847_RS21280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DB847_RS21285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DB847_RS21295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DB847_RS21310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DB847_RS21320	COG0534	Mate efflux family protein
DB847_RS21325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DB847_RS21335	COG3161	chorismate lyase activity
DB847_RS21340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DB847_RS21350	COG0023	Translation Initiation Factor
DB847_RS21360	COG4989	oxidoreductase activity
DB847_RS21370	COG0705	Rhomboid family
DB847_RS21385	COG1218	3'(2'),5'-bisphosphate nucleotidase
DB847_RS21395	COG0174	glutamine synthetase
DB847_RS21405	COG3852	Histidine kinase
DB847_RS21430	COG1091	dTDP-4-dehydrorhamnose reductase activity
DB847_RS21450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DB847_RS21455	COG0726	polysaccharide deacetylase
DB847_RS21470	COG0859	PFAM glycosyl transferase family 9
DB847_RS21490	COG3642	lipopolysaccharide core region biosynthetic process
DB847_RS21500	COG0463	Glycosyl transferase, family 2
DB847_RS21510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DB847_RS21530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DB847_RS21545	COG0561	phosphatase activity
DB847_RS21560	COG0583	DNA-binding transcription factor activity
DB847_RS21570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB847_RS21580	COG2081	HI0933 family
DB847_RS21585	COG0668	transmembrane transport
DB847_RS21590	COG1528	Iron-storage protein
DB847_RS21620	COG0606	chelatase, subunit chli
DB847_RS21625	COG3071	HemY protein
DB847_RS21630	COG2959	enzyme of heme biosynthesis
DB847_RS21640	COG0181	hydroxymethylbilane synthase activity
DB847_RS21655	COG0204	Acyl-transferase
DB847_RS21660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB847_RS21665	COG1464	Belongs to the NlpA lipoprotein family
DB847_RS21705	COG4689	acetoacetate decarboxylase
DB847_RS21715	COG3426	butyrate kinase activity
DB847_RS21720	COG0280	phosphate acetyltransferase
DB847_RS21725	COG0183	Belongs to the thiolase family
DB847_RS21740	COG2197	response regulator
DB847_RS21790	COG4964	Belongs to the GSP D family
DB847_RS21855	COG0733	neurotransmitter:sodium symporter activity
DB847_RS21880	COG3078	GTPase activator activity
DB847_RS21885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB847_RS21905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DB847_RS21905	COG0165	Argininosuccinate lyase
DB847_RS21910	COG0009	L-threonylcarbamoyladenylate synthase
DB847_RS21925	COG2922	Belongs to the Smg family
DB847_RS21930	COG0758	DNA mediated transformation
DB847_RS21935	COG1652	LysM domain
DB847_RS21940	COG0242	peptide deformylase activity
DB847_RS21945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB847_RS21950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB847_RS21950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DB847_RS21955	COG0569	domain protein
DB847_RS21960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DB847_RS21965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DB847_RS21970	COG1295	ribonuclease BN
DB847_RS21980	COG1490	D-aminoacyl-tRNA deacylase activity
DB847_RS21995	COG1349	DNA-binding transcription factor activity
DB847_RS22000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DB847_RS22005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DB847_RS22015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DB847_RS22025	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DB847_RS22040	COG0514	ATP-dependent DNA helicase (RecQ)
DB847_RS22060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DB847_RS22085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DB847_RS22110	COG0513	Belongs to the DEAD box helicase family
DB847_RS22165	COG4191	Histidine kinase
DB847_RS22165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB847_RS22180	COG0742	ribosomal rna small subunit methyltransferase
DB847_RS22190	COG0513	Belongs to the DEAD box helicase family
DB847_RS22210	COG0741	lytic transglycosylase activity
DB847_RS22215	COG0583	DNA-binding transcription factor activity
DB847_RS22220	COG2814	Major facilitator Superfamily
DB847_RS22285	COG2897	thiosulfate sulfurtransferase activity
DB847_RS22290	COG0398	Pfam SNARE associated Golgi protein
DB847_RS22295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DB847_RS22300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DB847_RS22305	COG0531	amino acid
DB847_RS22315	COG0784	Response regulator, receiver
DB847_RS22315	COG3437	response regulator, receiver
DB847_RS22330	COG2814	Major facilitator Superfamily
DB847_RS22345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DB847_RS22350	COG1051	belongs to the nudix hydrolase family
DB847_RS22385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DB847_RS22390	COG1965	Belongs to the frataxin family
DB847_RS22400	COG0019	diaminopimelate decarboxylase activity
DB847_RS22405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DB847_RS22415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DB847_RS22420	COG1011	Hydrolase
DB847_RS22425	COG0210	DNA helicase
DB847_RS22445	COG0517	IMP dehydrogenase activity
DB847_RS22460	COG1959	2 iron, 2 sulfur cluster binding
DB847_RS22480	COG1522	sequence-specific DNA binding
DB847_RS22505	COG3706	GGDEF domain
DB847_RS22530	COG0248	Ppx GppA phosphatase
DB847_RS22535	COG0513	Belongs to the DEAD box helicase family
DB847_RS22540	COG3118	belongs to the thioredoxin family
DB847_RS22550	COG2960	long-chain fatty acid transporting porin activity
DB847_RS22565	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DB847_RS22585	COG3978	acetolactate synthase activity
DB847_RS22590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB847_RS22605	COG0814	amino acid
DB847_RS22625	COG0242	peptide deformylase activity
DB847_RS22645	COG0516	GMP reductase activity
DB847_RS22690	COG0589	response to stress
DB847_RS22695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS22715	COG1823	symporter activity
DB847_RS22745	COG2076	Multidrug Resistance protein
DB847_RS22775	COG2095	MarC family integral membrane protein
DB847_RS22785	COG0678	peroxiredoxin activity
DB847_RS22785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DB847_RS22805	COG0477	Major facilitator Superfamily
DB847_RS22845	COG2186	Transcriptional regulator
DB847_RS22855	COG0246	Mannitol dehydrogenase
DB847_RS22860	COG1904	glucuronate isomerase
DB847_RS22865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB847_RS22870	COG0800	Aldolase
DB847_RS22875	COG2721	sulfolactate sulfo-lyase activity
DB847_RS22900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB847_RS22905	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB847_RS22910	COG2723	6-phospho-beta-galactosidase activity
DB847_RS22915	COG1609	Transcriptional regulator
DB847_RS22950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DB847_RS22955	COG1228	amidohydrolase
DB847_RS22960	COG0010	Belongs to the arginase family
DB847_RS22965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DB847_RS22985	COG0583	DNA-binding transcription factor activity
DB847_RS22990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DB847_RS22995	COG0288	reversible hydration of carbon dioxide
DB847_RS23005	COG3437	response regulator, receiver
DB847_RS23005	COG0784	Response regulator, receiver
DB847_RS23020	COG1278	Cold shock
DB847_RS23030	COG0251	oxidation-reduction process
DB847_RS23055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DB847_RS23060	COG3045	CreA protein
DB847_RS23065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DB847_RS23070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DB847_RS23080	COG1522	sequence-specific DNA binding
DB847_RS23090	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS23095	COG0789	Transcriptional regulator
DB847_RS23100	COG0110	maltose O-acetyltransferase activity
DB847_RS23105	COG2177	Part of the ABC transporter FtsEX involved in
DB847_RS23110	COG2884	Cell division ATP-binding protein ftsE
DB847_RS23115	COG0552	protein localization to endoplasmic reticulum
DB847_RS23120	COG0742	ribosomal rna small subunit methyltransferase
DB847_RS23135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DB847_RS23140	COG1335	isochorismatase
DB847_RS23175	COG0477	Major facilitator Superfamily
DB847_RS23230	COG1486	melibiose metabolic process
DB847_RS23235	COG2169	Transcriptional regulator
DB847_RS23255	COG1349	DNA-binding transcription factor activity
DB847_RS23280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS23280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS23280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS23290	COG0383	alpha-mannosidase activity
DB847_RS23295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS23295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB847_RS23295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB847_RS23310	COG0456	acetyltransferase
DB847_RS23320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DB847_RS23345	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DB847_RS23385	COG0531	amino acid
DB847_RS23390	COG1982	Orn Lys Arg decarboxylase major
DB847_RS23400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DB847_RS23415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DB847_RS23420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DB847_RS23425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DB847_RS23430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DB847_RS23435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DB847_RS23440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DB847_RS23450	COG0356	it plays a direct role in the translocation of protons across the membrane
DB847_RS23455	COG1475	DNA binding
DB847_RS23460	COG1192	Involved in chromosome partitioning
DB847_RS23465	COG0357	Ribosomal RNA small subunit methyltransferase G
DB847_RS23485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DB847_RS23490	COG1028	Short-chain dehydrogenase reductase Sdr
DB847_RS23500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DB847_RS23525	COG2986	histidine ammonia-lyase
DB847_RS23530	COG0463	Glycosyl transferase, family 2
DB847_RS23535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DB847_RS23550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB847_RS23555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB847_RS23575	COG2813	Specifically methylates the guanine in position
DB847_RS23600	COG0583	DNA-binding transcription factor activity
DB847_RS23605	COG0673	inositol 2-dehydrogenase activity
DB847_RS23620	COG0840	transmembrane signaling receptor activity
DB847_RS23625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DB847_RS23630	COG0706	membrane insertase activity
DB847_RS23635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DB847_RS23640	COG0594	ribonuclease P activity
DB847_RS23645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DB847_RS23650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB847_RS23735	COG2356	endonuclease I
DB847_RS23740	COG3040	lipid binding
DB847_RS23785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DB847_RS23805	COG0730	response to heat
DB847_RS23825	COG1342	Belongs to the UPF0251 family
DB847_RS23840	COG4584	PFAM Integrase catalytic
DB847_RS23945	COG0776	regulation of translation
DB847_RS24040	COG3702	type iv secretory pathway