locus-tag	class	description
DKL61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DKL61_RS00010	COG0592	DNA-directed DNA polymerase activity
DKL61_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DKL61_RS00020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKL61_RS00095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DKL61_RS00115	COG0497	DNA recombination
DKL61_RS00120	COG0352	thiamine-phosphate diphosphorylase activity
DKL61_RS00125	COG0351	phosphomethylpyrimidine kinase
DKL61_RS00140	COG1490	D-aminoacyl-tRNA deacylase activity
DKL61_RS00155	COG2205	protein histidine kinase activity
DKL61_RS00165	COG0339	signal peptide processing
DKL61_RS00195	COG1448	Aminotransferase
DKL61_RS00220	COG0793	Belongs to the peptidase S41A family
DKL61_RS00225	COG0326	Molecular chaperone. Has ATPase activity
DKL61_RS00235	COG0583	DNA-binding transcription factor activity
DKL61_RS00245	COG0549	Belongs to the carbamate kinase family
DKL61_RS00255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DKL61_RS00260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DKL61_RS00265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DKL61_RS00270	COG3422	double-strand break repair
DKL61_RS00275	COG3272	Protein of unknown function (DUF1722)
DKL61_RS00280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKL61_RS00285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKL61_RS00320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKL61_RS00330	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DKL61_RS00335	COG1561	YicC-like family, N-terminal region
DKL61_RS00340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKL61_RS00350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DKL61_RS00365	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKL61_RS00380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DKL61_RS00385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DKL61_RS00390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKL61_RS00395	COG1845	cytochrome c oxidase, subunit III
DKL61_RS00400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKL61_RS00410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKL61_RS00415	COG2814	Major facilitator Superfamily
DKL61_RS00420	COG0488	(ABC) transporter
DKL61_RS00425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKL61_RS00430	COG0546	phosphoglycolate phosphatase activity
DKL61_RS00440	COG0512	Glutamine amidotransferase of anthranilate synthase
DKL61_RS00450	COG0134	indole-3-glycerol-phosphate synthase activity
DKL61_RS00465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKL61_RS00475	COG0159	tryptophan synthase activity
DKL61_RS00480	COG0133	tryptophan synthase activity
DKL61_RS00520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DKL61_RS00550	COG1253	flavin adenine dinucleotide binding
DKL61_RS00555	COG0739	heme binding
DKL61_RS00565	COG0028	Belongs to the TPP enzyme family
DKL61_RS00570	COG0440	acetolactate synthase activity
DKL61_RS00580	COG1183	phosphatidylcholine synthase activity
DKL61_RS00660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DKL61_RS00665	COG0330	HflC and HflK could
DKL61_RS00670	COG0330	HflC and HflK could
DKL61_RS00685	COG0560	Phosphoserine phosphatase
DKL61_RS00685	COG3830	Belongs to the UPF0237 family
DKL61_RS00700	COG0617	tRNA 3'-terminal CCA addition
DKL61_RS00705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DKL61_RS00715	COG3477	response to acidic pH
DKL61_RS00720	COG3161	chorismate lyase activity
DKL61_RS00725	COG0493	'glutamate synthase
DKL61_RS00730	COG0070	glutamate synthase
DKL61_RS00730	COG0069	glutamate synthase activity
DKL61_RS00730	COG0067	glutamate synthase
DKL61_RS00740	COG2818	Glycosylase
DKL61_RS00745	COG3264	Mechanosensitive ion channel
DKL61_RS00745	COG1196	nuclear chromosome segregation
DKL61_RS00780	COG0038	chloride channel
DKL61_RS00795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DKL61_RS00815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DKL61_RS00825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DKL61_RS00840	COG1965	Belongs to the frataxin family
DKL61_RS00845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DKL61_RS00850	COG0509	glycine decarboxylation via glycine cleavage system
DKL61_RS00910	COG0126	phosphoglycerate kinase activity
DKL61_RS00915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKL61_RS00920	COG0438	transferase activity, transferring glycosyl groups
DKL61_RS00950	COG0583	DNA-binding transcription factor activity
DKL61_RS00955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKL61_RS00960	COG0756	dUTP diphosphatase activity
DKL61_RS00970	COG1538	Outer membrane efflux protein
DKL61_RS00975	COG2267	carboxylic ester hydrolase activity
DKL61_RS00980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DKL61_RS00985	COG0436	Aminotransferase
DKL61_RS00995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKL61_RS01000	COG2003	Belongs to the UPF0758 family
DKL61_RS01045	COG2271	Major facilitator Superfamily
DKL61_RS01155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKL61_RS01190	COG2304	oxidoreductase activity
DKL61_RS01195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DKL61_RS01205	COG0859	PFAM glycosyl transferase family 9
DKL61_RS01210	COG0859	PFAM glycosyl transferase family 9
DKL61_RS01225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKL61_RS01230	COG1584	GPR1 FUN34 yaaH family protein
DKL61_RS01245	COG1538	Outer membrane efflux protein
DKL61_RS01255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKL61_RS01260	COG0321	lipoyl(octanoyl) transferase activity
DKL61_RS01270	COG1686	Belongs to the peptidase S11 family
DKL61_RS01280	COG2951	lytic endotransglycosylase activity
DKL61_RS01285	COG0772	Belongs to the SEDS family
DKL61_RS01290	COG0768	penicillin binding
DKL61_RS01295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DKL61_RS01305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DKL61_RS01310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DKL61_RS01315	COG0037	tRNA processing
DKL61_RS01345	COG0840	transmembrane signaling receptor activity
DKL61_RS01355	COG0643	Histidine kinase
DKL61_RS01355	COG2198	Histidine kinase
DKL61_RS01355	COG0784	Response regulator, receiver
DKL61_RS01365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKL61_RS01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKL61_RS01375	COG0765	amino acid transport
DKL61_RS01385	COG0789	Transcriptional regulator
DKL61_RS01390	COG1297	OPT oligopeptide transporter protein
DKL61_RS01395	COG0525	valine-tRNA ligase activity
DKL61_RS01420	COG0659	secondary active sulfate transmembrane transporter activity
DKL61_RS01435	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DKL61_RS01440	COG0735	belongs to the Fur family
DKL61_RS01445	COG1121	(ABC) transporter
DKL61_RS01450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKL61_RS01455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DKL61_RS01460	COG2824	Alkylphosphonate utilization operon protein PhnA
DKL61_RS01465	COG1027	Aspartate ammonia-lyase
DKL61_RS01470	COG0583	DNA-binding transcription factor activity
DKL61_RS01505	COG1702	phosphate starvation-inducible protein PhoH
DKL61_RS01515	COG4535	Mg2 and Co2 transporter CorC
DKL61_RS01520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DKL61_RS01535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKL61_RS01550	COG1113	amino acid transport
DKL61_RS01560	COG2914	Belongs to the UPF0125 (RnfH) family
DKL61_RS01570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKL61_RS01575	COG1959	2 iron, 2 sulfur cluster binding
DKL61_RS01580	COG0165	Argininosuccinate lyase
DKL61_RS01620	COG1643	Atp-dependent helicase
DKL61_RS01715	COG0656	L-ascorbic acid biosynthetic process
DKL61_RS01720	COG3835	regulator
DKL61_RS01725	COG2721	sulfolactate sulfo-lyase activity
DKL61_RS01730	COG2271	Major facilitator Superfamily
DKL61_RS01735	COG4948	Mandelate Racemase Muconate Lactonizing
DKL61_RS01740	COG4948	Mandelate Racemase Muconate Lactonizing
DKL61_RS01750	COG2084	Dehydrogenase
DKL61_RS01790	COG2211	Major facilitator Superfamily
DKL61_RS01795	COG1397	ADP-ribosylglycohydrolase
DKL61_RS01800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKL61_RS01825	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DKL61_RS01865	COG0252	asparaginase activity
DKL61_RS01875	COG1515	deoxyribonuclease V activity
DKL61_RS01885	COG0277	FAD linked oxidase domain protein
DKL61_RS01895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKL61_RS01905	COG1294	oxidase, subunit
DKL61_RS01915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKL61_RS01915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DKL61_RS01930	COG2217	Heavy metal translocating P-type atpase
DKL61_RS01945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKL61_RS01955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKL61_RS01960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DKL61_RS02020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKL61_RS02040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DKL61_RS02045	COG4656	Part of a membrane complex involved in electron transport
DKL61_RS02050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DKL61_RS02055	COG4816	utilization protein
DKL61_RS02070	COG4819	ethanolamine utilization protein
DKL61_RS02100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DKL61_RS02105	COG0280	phosphate acetyltransferase
DKL61_RS02110	COG4812	Cobalamin adenosyltransferase
DKL61_RS02115	COG4766	ethanolamine catabolic process
DKL61_RS02125	COG4810	utilization protein
DKL61_RS02130	COG1414	Transcriptional regulator
DKL61_RS02135	COG2271	Major facilitator Superfamily
DKL61_RS02140	COG2721	sulfolactate sulfo-lyase activity
DKL61_RS02145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKL61_RS02175	COG0004	ammonium transporteR
DKL61_RS02185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DKL61_RS02190	COG1882	Formate acetyltransferase
DKL61_RS02195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DKL61_RS02200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DKL61_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS02335	COG0582	viral genome integration into host DNA
DKL61_RS02345	COG3209	COG3209 Rhs family protein
DKL61_RS02375	COG0582	viral genome integration into host DNA
DKL61_RS02400	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DKL61_RS02420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKL61_RS02425	COG2267	carboxylic ester hydrolase activity
DKL61_RS02430	COG2453	phosphatase
DKL61_RS02430	COG0671	phosphoesterase, PA-phosphatase related
DKL61_RS02445	COG4589	Belongs to the CDS family
DKL61_RS02460	COG1840	ABC-type Fe3 transport system, periplasmic component
DKL61_RS02465	COG3842	ATPase activity
DKL61_RS02475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKL61_RS02480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DKL61_RS02500	COG0513	Belongs to the DEAD box helicase family
DKL61_RS02505	COG0582	viral genome integration into host DNA
DKL61_RS02550	COG0210	DNA helicase
DKL61_RS02590	COG1475	DNA binding
DKL61_RS02650	COG2378	regulation of single-species biofilm formation
DKL61_RS02665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DKL61_RS02670	COG0360	Binds together with S18 to 16S ribosomal RNA
DKL61_RS02680	COG0359	binds to the 23S rRNA
DKL61_RS02685	COG0305	Participates in initiation and elongation during chromosome replication
DKL61_RS02690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DKL61_RS02745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DKL61_RS02750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DKL61_RS02755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DKL61_RS02760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKL61_RS02765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKL61_RS02780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKL61_RS02785	COG0215	cysteine-tRNA ligase activity
DKL61_RS02805	COG0697	spore germination
DKL61_RS02855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKL61_RS02870	COG1530	ribonuclease E activity
DKL61_RS02895	COG0589	response to stress
DKL61_RS02920	COG0069	glutamate synthase activity
DKL61_RS02925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKL61_RS02930	COG0653	protein targeting
DKL61_RS02935	COG0166	Belongs to the GPI family
DKL61_RS02940	COG0405	Gamma-glutamyltransferase
DKL61_RS02965	COG0275	rRNA processing
DKL61_RS02985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKL61_RS02990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DKL61_RS02995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DKL61_RS03000	COG0772	Belongs to the SEDS family
DKL61_RS03005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DKL61_RS03035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DKL61_RS03045	COG0739	heme binding
DKL61_RS03065	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DKL61_RS03070	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKL61_RS03080	COG0281	malic enzyme
DKL61_RS03085	COG0433	COG0433 Predicted ATPase
DKL61_RS03095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DKL61_RS03100	COG0814	amino acid
DKL61_RS03120	COG2188	Transcriptional regulator
DKL61_RS03125	COG4993	Dehydrogenase
DKL61_RS03130	COG4772	TonB-dependent receptor
DKL61_RS03135	COG0590	tRNA wobble adenosine to inosine editing
DKL61_RS03140	COG3040	lipid binding
DKL61_RS03145	COG3257	ureidoglycine aminohydrolase activity
DKL61_RS03150	COG2814	Major facilitator Superfamily
DKL61_RS03155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKL61_RS03160	COG1017	nitric oxide dioxygenase activity
DKL61_RS03160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKL61_RS03170	COG2915	High frequency lysogenization protein hflD homolog
DKL61_RS03175	COG0482	sulfurtransferase activity
DKL61_RS03190	COG0431	NADPH-dependent FMN reductase
DKL61_RS03205	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
DKL61_RS03210	COG1902	pentaerythritol trinitrate reductase activity
DKL61_RS03255	COG3507	Belongs to the glycosyl hydrolase 43 family
DKL61_RS03255	COG2382	esterase
DKL61_RS03255	COG3693	PFAM glycoside hydrolase, family 10
DKL61_RS03265	COG1902	pentaerythritol trinitrate reductase activity
DKL61_RS03305	COG1289	transmembrane transporter activity
DKL61_RS03315	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKL61_RS03325	COG0436	Aminotransferase
DKL61_RS03335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKL61_RS03375	COG0484	heat shock protein binding
DKL61_RS03395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKL61_RS03400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DKL61_RS03405	COG3642	lipopolysaccharide core region biosynthetic process
DKL61_RS03425	COG1560	Kdo2-lipid A biosynthetic process
DKL61_RS03445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DKL61_RS03455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKL61_RS03465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKL61_RS03480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKL61_RS03490	COG2315	Protein conserved in bacteria
DKL61_RS03495	COG2022	thiamine diphosphate biosynthetic process
DKL61_RS03500	COG2022	thiamine diphosphate biosynthetic process
DKL61_RS03500	COG2104	thiamine diphosphate biosynthetic process
DKL61_RS03505	COG2363	Small membrane protein
DKL61_RS03520	COG3139	Protein of unknown function (DUF1315)
DKL61_RS03545	COG2873	o-acetylhomoserine
DKL61_RS03555	COG0791	NLP P60 protein
DKL61_RS03610	COG0481	GTPase activity
DKL61_RS03615	COG0681	Belongs to the peptidase S26 family
DKL61_RS03620	COG0571	ribonuclease III activity
DKL61_RS03625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DKL61_RS03655	COG2264	protein methyltransferase activity
DKL61_RS03660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKL61_RS03705	COG2304	oxidoreductase activity
DKL61_RS03720	COG0714	Associated with various cellular activities
DKL61_RS03730	COG0514	ATP-dependent DNA helicase (RecQ)
DKL61_RS03735	COG2365	Tyrosine phosphatase family
DKL61_RS03770	COG4175	Glycine betaine
DKL61_RS03780	COG0501	Belongs to the peptidase M48B family
DKL61_RS03785	COG2119	membrane
DKL61_RS03790	COG1570	exodeoxyribonuclease VII activity
DKL61_RS03805	COG0301	tRNA thio-modification
DKL61_RS03805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKL61_RS03810	COG1217	gtp-binding protein TYPA
DKL61_RS03815	COG0583	DNA-binding transcription factor activity
DKL61_RS03820	COG2610	gluconate transmembrane transporter activity
DKL61_RS03825	COG3048	D-serine ammonia-lyase activity
DKL61_RS03835	COG0598	Magnesium transport protein CorA
DKL61_RS03845	COG4221	oxidoreductase activity
DKL61_RS03850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DKL61_RS03855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKL61_RS03895	COG2223	nitrite transmembrane transporter activity
DKL61_RS03900	COG0542	response to heat
DKL61_RS03930	COG1294	oxidase, subunit
DKL61_RS03940	COG1294	oxidase, subunit
DKL61_RS03965	COG2894	cell division
DKL61_RS03970	COG0850	regulation of cytokinetic process
DKL61_RS03975	COG1040	competence protein
DKL61_RS03985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DKL61_RS03990	COG4181	ATPase activity
DKL61_RS04000	COG1376	ErfK ybiS ycfS ynhG family protein
DKL61_RS04010	COG3738	Protein conserved in bacteria
DKL61_RS04055	COG1862	Preprotein translocase
DKL61_RS04070	COG2009	succinate dehydrogenase
DKL61_RS04075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DKL61_RS04085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKL61_RS04115	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS04120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DKL61_RS04125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKL61_RS04135	COG0306	phosphate transporter
DKL61_RS04140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKL61_RS04145	COG2062	phosphohistidine phosphatase, SixA
DKL61_RS04150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKL61_RS04160	COG0243	molybdopterin cofactor binding
DKL61_RS04180	COG3188	usher protein
DKL61_RS04190	COG3121	Chaperone
DKL61_RS04195	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKL61_RS04200	COG0717	Belongs to the dCTP deaminase family
DKL61_RS04225	COG2999	glutathione oxidoreductase activity
DKL61_RS04240	COG1215	transferase activity, transferring glycosyl groups
DKL61_RS04245	COG1088	dTDP-glucose 4,6-dehydratase activity
DKL61_RS04250	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKL61_RS04260	COG0438	transferase activity, transferring glycosyl groups
DKL61_RS04275	COG3695	enzyme binding
DKL61_RS04280	COG0793	Belongs to the peptidase S41A family
DKL61_RS04285	COG0436	Aminotransferase
DKL61_RS04290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DKL61_RS04295	COG0024	Methionine aminopeptidase
DKL61_RS04305	COG0501	Belongs to the peptidase M48B family
DKL61_RS04310	COG0628	permease
DKL61_RS04315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DKL61_RS04320	COG0489	protein tyrosine kinase activity
DKL61_RS04335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKL61_RS04350	COG1678	Uncharacterized ACR, COG1678
DKL61_RS04355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKL61_RS04375	COG0671	phosphoesterase, PA-phosphatase related
DKL61_RS04380	COG1132	(ABC) transporter
DKL61_RS04385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DKL61_RS04395	COG1362	aminopeptidase activity
DKL61_RS04410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DKL61_RS04410	COG1648	precorrin-2 dehydrogenase activity
DKL61_RS04415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DKL61_RS04430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKL61_RS04475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DKL61_RS04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKL61_RS04485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DKL61_RS04490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKL61_RS04500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKL61_RS04515	COG0546	phosphoglycolate phosphatase activity
DKL61_RS04520	COG0583	DNA-binding transcription factor activity
DKL61_RS04525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKL61_RS04530	COG0371	Dehydrogenase
DKL61_RS04540	COG0149	triose-phosphate isomerase activity
DKL61_RS04585	COG3723	Recombinational DNA repair protein, rece pathway
DKL61_RS04590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKL61_RS04610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DKL61_RS04635	COG0582	viral genome integration into host DNA
DKL61_RS04720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKL61_RS04735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKL61_RS04740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DKL61_RS04745	COG2813	Specifically methylates the guanine in position
DKL61_RS04745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKL61_RS04750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKL61_RS04780	COG1739	Uncharacterized protein family UPF0029
DKL61_RS04785	COG0596	Alpha beta hydrolase
DKL61_RS04790	COG0616	signal peptide processing
DKL61_RS04805	COG2816	NAD+ diphosphatase activity
DKL61_RS04815	COG3158	transport of potassium into the cell
DKL61_RS04820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DKL61_RS04825	COG1393	Belongs to the ArsC family
DKL61_RS04850	COG2223	nitrite transmembrane transporter activity
DKL61_RS04855	COG0679	Auxin Efflux Carrier
DKL61_RS04860	COG2204	response regulator
DKL61_RS04865	COG3852	Histidine kinase
DKL61_RS04885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DKL61_RS04905	COG0544	peptidyl-prolyl cis-trans isomerase activity
DKL61_RS04915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DKL61_RS04925	COG0776	regulation of translation
DKL61_RS04930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKL61_RS04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKL61_RS04940	COG1286	toxin biosynthetic process
DKL61_RS04970	COG0028	Belongs to the TPP enzyme family
DKL61_RS04980	COG0795	lipopolysaccharide-transporting ATPase activity
DKL61_RS04985	COG0795	lipopolysaccharide-transporting ATPase activity
DKL61_RS05015	COG1160	GTP binding
DKL61_RS05020	COG1301	dicarboxylic acid transport
DKL61_RS05025	COG1380	Effector of murein hydrolase LrgA
DKL61_RS05030	COG1346	cytolysis
DKL61_RS05050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKL61_RS05055	COG0667	Aldo Keto reductase
DKL61_RS05060	COG2353	YceI-like domain
DKL61_RS05065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKL61_RS05070	COG2823	Periplasmic or secreted lipoprotein
DKL61_RS05075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DKL61_RS05080	COG0792	nuclease activity
DKL61_RS05085	COG3107	peptidoglycan biosynthetic process
DKL61_RS05105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKL61_RS05110	COG0418	dihydroorotase activity
DKL61_RS05115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DKL61_RS05125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DKL61_RS05135	COG1476	TRANSCRIPTIONal
DKL61_RS05190	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS05215	COG2840	Smr protein MutS2
DKL61_RS05220	COG0387	Pfam Sodium calcium exchanger
DKL61_RS05230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DKL61_RS05240	COG0424	maF-like protein
DKL61_RS05245	COG1399	metal-binding, possibly nucleic acid-binding protein
DKL61_RS05250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DKL61_RS05275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKL61_RS05280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKL61_RS05285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKL61_RS05290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DKL61_RS05305	COG0084	hydrolase, TatD family'
DKL61_RS05315	COG1151	hydroxylamine reductase activity
DKL61_RS05330	COG0443	Heat shock 70 kDa protein
DKL61_RS05335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DKL61_RS05350	COG1104	cysteine desulfurase activity
DKL61_RS05375	COG0028	Belongs to the TPP enzyme family
DKL61_RS05385	COG1215	transferase activity, transferring glycosyl groups
DKL61_RS05390	COG1671	Belongs to the UPF0178 family
DKL61_RS05415	COG2091	lysine biosynthetic process via aminoadipic acid
DKL61_RS05420	COG0477	Major facilitator Superfamily
DKL61_RS05435	COG0406	alpha-ribazole phosphatase activity
DKL61_RS05450	COG3121	Chaperone
DKL61_RS05460	COG3188	usher protein
DKL61_RS05465	COG3121	Chaperone
DKL61_RS05485	COG0679	Auxin Efflux Carrier
DKL61_RS05490	COG1538	Outer membrane efflux protein
DKL61_RS05505	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKL61_RS05510	COG2205	protein histidine kinase activity
DKL61_RS05535	COG3188	usher protein
DKL61_RS05565	COG4149	molybdate abc transporter
DKL61_RS05570	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKL61_RS05575	COG2181	nitrate reductase activity
DKL61_RS05580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DKL61_RS05590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DKL61_RS05595	COG2223	nitrite transmembrane transporter activity
DKL61_RS05605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DKL61_RS05610	COG2197	response regulator
DKL61_RS05615	COG3850	Histidine kinase
DKL61_RS05620	COG0315	cyclic pyranopterin monophosphate synthase activity
DKL61_RS05640	COG0303	'Molybdopterin
DKL61_RS05645	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKL61_RS05650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKL61_RS05655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DKL61_RS05660	COG0527	aspartate kinase activity
DKL61_RS05665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DKL61_RS05690	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKL61_RS05695	COG0667	Aldo Keto reductase
DKL61_RS05700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKL61_RS05705	COG0805	protein transport
DKL61_RS05730	COG4771	TonB-dependent receptor
DKL61_RS05740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKL61_RS05745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DKL61_RS05805	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS05830	COG2226	methyltransferase
DKL61_RS05835	COG0473	3-isopropylmalate dehydrogenase activity
DKL61_RS05860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKL61_RS05865	COG0573	inorganic phosphate transmembrane transporter activity
DKL61_RS05870	COG0581	inorganic phosphate transmembrane transporter activity
DKL61_RS05880	COG0704	Plays a role in the regulation of phosphate uptake
DKL61_RS05900	COG1566	PFAM secretion protein HlyD family protein
DKL61_RS05905	COG2814	Major facilitator Superfamily
DKL61_RS05960	COG0833	amino acid
DKL61_RS05985	COG0156	8-amino-7-oxononanoate synthase activity
DKL61_RS05990	COG2226	methyltransferase
DKL61_RS05990	COG1073	alpha beta
DKL61_RS06015	COG2814	Major facilitator Superfamily
DKL61_RS06040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DKL61_RS06050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKL61_RS06065	COG2314	TM2 domain
DKL61_RS06075	COG0138	bifunctional purine biosynthesis protein purh
DKL61_RS06105	COG1064	alcohol dehydrogenase
DKL61_RS06110	COG2321	neutral zinc metallopeptidase
DKL61_RS06115	COG0284	orotidine-5'-phosphate decarboxylase activity
DKL61_RS06125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DKL61_RS06140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKL61_RS06170	COG2850	peptidyl-arginine hydroxylation
DKL61_RS06230	COG0542	response to heat
DKL61_RS06240	COG0519	Catalyzes the synthesis of GMP from XMP
DKL61_RS06240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKL61_RS06250	COG3150	esterase
DKL61_RS06260	COG3577	Aspartyl protease
DKL61_RS06275	COG3204	pilus organization
DKL61_RS06285	COG4591	ABC-type transport system involved in lipoprotein release permease component
DKL61_RS06300	COG4607	ABC-type enterochelin transport system periplasmic component
DKL61_RS06315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKL61_RS06320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKL61_RS06320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKL61_RS06345	COG0713	ATP synthesis coupled electron transport
DKL61_RS06360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DKL61_RS06385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKL61_RS06390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKL61_RS06400	COG2226	methyltransferase
DKL61_RS06405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKL61_RS06420	COG1278	Cold shock
DKL61_RS06450	COG3012	SEC-C Motif Domain Protein
DKL61_RS06455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKL61_RS06475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKL61_RS06480	COG2076	Multidrug Resistance protein
DKL61_RS06495	COG0235	Class ii aldolase
DKL61_RS06495	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DKL61_RS06500	COG0745	RESPONSE REGULATOR receiver
DKL61_RS06505	COG2205	protein histidine kinase activity
DKL61_RS06510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKL61_RS06515	COG3300	MHYT domain
DKL61_RS06515	COG5001	Diguanylate cyclase
DKL61_RS06535	COG2096	Adenosyltransferase
DKL61_RS06550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKL61_RS06560	COG0477	Major facilitator Superfamily
DKL61_RS06565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKL61_RS06570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DKL61_RS06575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DKL61_RS06575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DKL61_RS06580	COG2878	Part of a membrane complex involved in electron transport
DKL61_RS06590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKL61_RS06595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKL61_RS06685	COG0629	single-stranded DNA binding
DKL61_RS06695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKL61_RS06750	COG3188	usher protein
DKL61_RS06755	COG1422	Protein of unknown function (DUF1090)
DKL61_RS06760	COG2205	protein histidine kinase activity
DKL61_RS06760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKL61_RS06765	COG2197	response regulator
DKL61_RS06830	COG0023	Translation Initiation Factor
DKL61_RS06835	COG4206	TonB-dependent receptor
DKL61_RS06855	COG0557	exoribonuclease II activity
DKL61_RS07180	COG3721	Heme iron utilization protein
DKL61_RS07190	COG0748	coenzyme F420 binding
DKL61_RS07200	COG2814	Major facilitator Superfamily
DKL61_RS07210	COG1301	dicarboxylic acid transport
DKL61_RS07215	COG0302	gtp cyclohydrolase
DKL61_RS07230	COG2814	Major facilitator Superfamily
DKL61_RS07240	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKL61_RS07260	COG0720	synthase
DKL61_RS07265	COG0729	surface antigen
DKL61_RS07270	COG2911	Protein conserved in bacteria
DKL61_RS07280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKL61_RS07285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DKL61_RS07290	COG4191	Histidine kinase
DKL61_RS07295	COG0028	Belongs to the TPP enzyme family
DKL61_RS07300	COG0705	Rhomboid family
DKL61_RS07305	COG2255	four-way junction helicase activity
DKL61_RS07325	COG1842	Phage shock protein A
DKL61_RS07330	COG3789	protein conserved in bacteria
DKL61_RS07350	COG0583	DNA-binding transcription factor activity
DKL61_RS07370	COG0189	ligase activity
DKL61_RS07395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKL61_RS07405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DKL61_RS07410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DKL61_RS07420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKL61_RS07425	COG1278	Cold shock
DKL61_RS07435	COG1012	belongs to the aldehyde dehydrogenase family
DKL61_RS07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKL61_RS07465	COG0247	lactate metabolic process
DKL61_RS07470	COG1139	Iron-sulfur cluster binding protein
DKL61_RS07490	COG0252	asparaginase activity
DKL61_RS07495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKL61_RS07500	COG0494	nUDIX hydrolase
DKL61_RS07505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKL61_RS07515	COG2862	Uncharacterized protein family, UPF0114
DKL61_RS07530	COG0037	tRNA processing
DKL61_RS07540	COG0271	Belongs to the BolA IbaG family
DKL61_RS07560	COG0582	viral genome integration into host DNA
DKL61_RS07565	COG0582	viral genome integration into host DNA
DKL61_RS07580	COG0183	Belongs to the thiolase family
DKL61_RS07585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKL61_RS07590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKL61_RS07605	COG2851	Citrate transporter
DKL61_RS07610	COG0583	DNA-binding transcription factor activity
DKL61_RS07645	COG0679	Auxin Efflux Carrier
DKL61_RS07685	COG1566	PFAM secretion protein HlyD family protein
DKL61_RS07715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKL61_RS07720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKL61_RS07730	COG0667	Aldo Keto reductase
DKL61_RS07760	COG2159	amidohydrolase
DKL61_RS07765	COG2828	Protein conserved in bacteria
DKL61_RS07770	COG0583	DNA-binding transcription factor activity
DKL61_RS07790	COG1053	succinate dehydrogenase
DKL61_RS07795	COG1053	succinate dehydrogenase
DKL61_RS07810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DKL61_RS07815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DKL61_RS07835	COG1289	transmembrane transporter activity
DKL61_RS07840	COG2900	Belongs to the SlyX family
DKL61_RS07855	COG0488	(ABC) transporter
DKL61_RS07870	COG0513	Belongs to the DEAD box helicase family
DKL61_RS07885	COG2814	Major facilitator Superfamily
DKL61_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
DKL61_RS07905	COG3384	dioxygenase
DKL61_RS07915	COG2271	Major facilitator Superfamily
DKL61_RS07925	COG3971	2-oxopent-4-enoate hydratase activity
DKL61_RS07935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKL61_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS07980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKL61_RS08010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DKL61_RS08025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKL61_RS08030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKL61_RS08035	COG0204	Acyl-transferase
DKL61_RS08085	COG0305	Participates in initiation and elongation during chromosome replication
DKL61_RS08135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKL61_RS08140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKL61_RS08145	COG0322	excinuclease ABC activity
DKL61_RS08275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DKL61_RS08295	COG0135	phosphoribosylanthranilate isomerase activity
DKL61_RS08300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DKL61_RS08305	COG0285	dihydrofolate synthase activity
DKL61_RS08320	COG0142	geranyltranstransferase activity
DKL61_RS08350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DKL61_RS08365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DKL61_RS08370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DKL61_RS08375	COG1882	Formate acetyltransferase
DKL61_RS08385	COG1704	LemA family
DKL61_RS08395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DKL61_RS08405	COG0776	regulation of translation
DKL61_RS08410	COG0072	phenylalanine-tRNA ligase activity
DKL61_RS08415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DKL61_RS08430	COG0124	histidyl-tRNA synthetase
DKL61_RS08450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DKL61_RS08465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKL61_RS08465	COG2755	lipolytic protein G-D-S-L family
DKL61_RS08480	COG3038	cytochrome b561
DKL61_RS08490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DKL61_RS08495	COG0492	ferredoxin-NADP+ reductase activity
DKL61_RS08500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKL61_RS08505	COG4067	protein conserved in archaea
DKL61_RS08505	COG0189	ligase activity
DKL61_RS08520	COG2951	lytic endotransglycosylase activity
DKL61_RS08530	COG0586	Pfam SNARE associated Golgi protein
DKL61_RS08560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DKL61_RS08570	COG0038	chloride channel
DKL61_RS08590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKL61_RS08595	COG3154	lipid carrier protein
DKL61_RS08605	COG0826	peptidase U32
DKL61_RS08615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKL61_RS08620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKL61_RS08625	COG0322	excinuclease ABC activity
DKL61_RS08630	COG2351	hydroxyisourate hydrolase activity
DKL61_RS08660	COG0582	viral genome integration into host DNA
DKL61_RS08675	COG3122	Protein conserved in bacteria
DKL61_RS08680	COG3022	response to hydroperoxide
DKL61_RS08690	COG1492	cobalamin metabolic process
DKL61_RS08695	COG0406	alpha-ribazole phosphatase activity
DKL61_RS08705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DKL61_RS08720	COG1122	ATPase activity
DKL61_RS08755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKL61_RS08820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DKL61_RS08830	COG1648	precorrin-2 dehydrogenase activity
DKL61_RS08835	COG2096	Adenosyltransferase
DKL61_RS08840	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS08850	COG2813	Specifically methylates the guanine in position
DKL61_RS08870	COG0697	spore germination
DKL61_RS08880	COG2969	positive regulation of protein catabolic process
DKL61_RS08885	COG0625	glutathione transferase activity
DKL61_RS08895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKL61_RS08905	COG0477	Major facilitator Superfamily
DKL61_RS08915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKL61_RS08955	COG2200	EAL domain
DKL61_RS08960	COG0688	phosphatidylethanolamine metabolic process
DKL61_RS09005	COG3034	peptidoglycan biosynthetic process
DKL61_RS09010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DKL61_RS09020	COG2194	sulfuric ester hydrolase activity
DKL61_RS09030	COG1607	acyl-coa hydrolase
DKL61_RS09035	COG4651	solute:proton antiporter activity
DKL61_RS09035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKL61_RS09060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKL61_RS09065	COG0006	proline dipeptidase activity
DKL61_RS09070	COG3079	Belongs to the UPF0149 family
DKL61_RS09085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DKL61_RS09095	COG1160	GTP binding
DKL61_RS09100	COG0582	viral genome integration into host DNA
DKL61_RS09110	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS09250	COG2315	Protein conserved in bacteria
DKL61_RS09255	COG3646	Phage regulatory protein
DKL61_RS09310	COG0584	glycerophosphoryl diester phosphodiesterase
DKL61_RS09315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DKL61_RS09330	COG0488	(ABC) transporter
DKL61_RS09340	COG3634	alkyl hydroperoxide reductase activity
DKL61_RS09370	COG2246	polysaccharide biosynthetic process
DKL61_RS09395	COG0745	RESPONSE REGULATOR receiver
DKL61_RS09410	COG2194	sulfuric ester hydrolase activity
DKL61_RS09420	COG3642	lipopolysaccharide core region biosynthetic process
DKL61_RS09445	COG0804	urea catabolic process
DKL61_RS09450	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DKL61_RS09460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DKL61_RS09465	COG0829	nickel cation binding
DKL61_RS09475	COG2226	methyltransferase
DKL61_RS09485	COG0601	transmembrane transport
DKL61_RS09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKL61_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS09615	COG3209	COG3209 Rhs family protein
DKL61_RS09780	COG0583	DNA-binding transcription factor activity
DKL61_RS09785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DKL61_RS09815	COG2271	Major facilitator Superfamily
DKL61_RS09820	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DKL61_RS09825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKL61_RS09835	COG0251	oxidation-reduction process
DKL61_RS09840	COG1522	sequence-specific DNA binding
DKL61_RS09850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKL61_RS09875	COG2351	hydroxyisourate hydrolase activity
DKL61_RS09890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKL61_RS09895	COG1116	anion transmembrane transporter activity
DKL61_RS09915	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS09925	COG1136	(ABC) transporter
DKL61_RS09960	COG0583	DNA-binding transcription factor activity
DKL61_RS09965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DKL61_RS09980	COG0754	glutathionylspermidine amidase activity
DKL61_RS10000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKL61_RS10010	COG1757	Na H antiporter
DKL61_RS10045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKL61_RS10050	COG1917	Cupin 2, conserved barrel domain protein
DKL61_RS10050	COG4977	sequence-specific DNA binding
DKL61_RS10075	COG0765	amino acid transport
DKL61_RS10080	COG0765	amino acid transport
DKL61_RS10085	COG1126	abc transporter atp-binding protein
DKL61_RS10090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKL61_RS10140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DKL61_RS10160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DKL61_RS10165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKL61_RS10175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DKL61_RS10180	COG2251	uridine kinase activity
DKL61_RS10180	COG0195	Participates in both transcription termination and antitermination
DKL61_RS10185	COG0779	Required for maturation of 30S ribosomal subunits
DKL61_RS10210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DKL61_RS10215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DKL61_RS10270	COG2271	Major facilitator Superfamily
DKL61_RS10280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKL61_RS10285	COG2706	6-phosphogluconolactonase activity
DKL61_RS10380	COG1216	Glycosyl transferase, family 2
DKL61_RS10380	COG0438	transferase activity, transferring glycosyl groups
DKL61_RS10410	COG0038	chloride channel
DKL61_RS10415	COG1733	regulation of RNA biosynthetic process
DKL61_RS10435	COG3152	Membrane
DKL61_RS10525	COG4416	COG NOG18757 non supervised orthologous group
DKL61_RS10555	COG0371	Dehydrogenase
DKL61_RS10560	COG2169	Transcriptional regulator
DKL61_RS10560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKL61_RS10565	COG1335	isochorismatase
DKL61_RS10570	COG1733	regulation of RNA biosynthetic process
DKL61_RS10590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DKL61_RS10595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKL61_RS10600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKL61_RS10605	COG0277	FAD linked oxidase domain protein
DKL61_RS10615	COG5007	Belongs to the BolA IbaG family
DKL61_RS10630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKL61_RS10635	COG1127	ABC transporter
DKL61_RS10645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKL61_RS10655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKL61_RS10660	COG1137	ATPase activity
DKL61_RS10665	COG2194	sulfuric ester hydrolase activity
DKL61_RS10685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DKL61_RS10690	COG3178	'Phosphotransferase
DKL61_RS10695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKL61_RS10725	COG2226	methyltransferase
DKL61_RS10730	COG0500	methyltransferase
DKL61_RS10735	COG4574	serine-type endopeptidase inhibitor activity
DKL61_RS10740	COG2200	EAL domain
DKL61_RS10745	COG3781	membrane
DKL61_RS10760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DKL61_RS10765	COG0493	'glutamate synthase
DKL61_RS10765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKL61_RS10775	COG3541	Predicted nucleotidyltransferase
DKL61_RS10805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DKL61_RS10820	COG0679	Auxin Efflux Carrier
DKL61_RS10835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKL61_RS10840	COG2983	Belongs to the UPF0260 family
DKL61_RS10850	COG0754	glutathionylspermidine amidase activity
DKL61_RS10865	COG1454	alcohol dehydrogenase
DKL61_RS10870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKL61_RS10875	COG2721	sulfolactate sulfo-lyase activity
DKL61_RS10885	COG2271	Major facilitator Superfamily
DKL61_RS10890	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DKL61_RS10900	COG1691	(AIR) carboxylase
DKL61_RS10905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKL61_RS10915	COG2271	Major facilitator Superfamily
DKL61_RS10925	COG4953	penicillin-binding protein 1C
DKL61_RS10930	COG2373	Large extracellular alpha-helical protein
DKL61_RS10940	COG1280	lysine exporter protein (LysE YggA)
DKL61_RS10955	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS10985	COG0500	methyltransferase
DKL61_RS10990	COG1120	ATPase activity
DKL61_RS10995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKL61_RS11035	COG3188	usher protein
DKL61_RS11060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKL61_RS11065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DKL61_RS11075	COG3260	NADH ubiquinone oxidoreductase 20
DKL61_RS11080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKL61_RS11085	COG3261	NADH dehydrogenase
DKL61_RS11085	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DKL61_RS11095	COG4237	Hydrogenase 4 membrane
DKL61_RS11100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKL61_RS11105	COG0650	Formate hydrogenlyase subunit 4
DKL61_RS11110	COG0651	ATP synthesis coupled electron transport
DKL61_RS11115	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKL61_RS11125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DKL61_RS11130	COG0298	carbon dioxide binding
DKL61_RS11135	COG0409	Hydrogenase expression formation protein
DKL61_RS11140	COG0309	Hydrogenase expression formation protein (HypE)
DKL61_RS11145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DKL61_RS11150	COG2116	formate transmembrane transporter activity
DKL61_RS11155	COG3604	Transcriptional regulator
DKL61_RS11160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKL61_RS11165	COG1921	L-seryl-tRNASec selenium transferase activity
DKL61_RS11180	COG2391	methyltransferase activity
DKL61_RS11185	COG0425	Belongs to the sulfur carrier protein TusA family
DKL61_RS11190	COG0745	RESPONSE REGULATOR receiver
DKL61_RS11195	COG2205	protein histidine kinase activity
DKL61_RS11200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DKL61_RS11210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DKL61_RS11245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DKL61_RS11250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKL61_RS11270	COG1629	transport
DKL61_RS11275	COG0039	L-malate dehydrogenase activity
DKL61_RS11340	COG2755	lipolytic protein G-D-S-L family
DKL61_RS11340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKL61_RS11345	COG2755	lipolytic protein G-D-S-L family
DKL61_RS11345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKL61_RS11355	COG1413	lyase activity
DKL61_RS11375	COG0745	RESPONSE REGULATOR receiver
DKL61_RS11385	COG0484	heat shock protein binding
DKL61_RS11395	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKL61_RS11400	COG1733	regulation of RNA biosynthetic process
DKL61_RS11445	COG2920	part of a sulfur-relay system
DKL61_RS11450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKL61_RS11460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKL61_RS11465	COG0392	lysyltransferase activity
DKL61_RS11475	COG3842	ATPase activity
DKL61_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKL61_RS11485	COG1177	transmembrane transport
DKL61_RS11495	COG0116	Belongs to the methyltransferase superfamily
DKL61_RS11495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DKL61_RS11515	COG0300	oxidoreductase activity
DKL61_RS11525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKL61_RS11530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DKL61_RS11535	COG2835	tetraacyldisaccharide 4'-kinase activity
DKL61_RS11545	COG0848	biopolymer transport protein
DKL61_RS11570	COG3115	cell septum assembly
DKL61_RS11590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKL61_RS11595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKL61_RS11640	COG2925	Exonuclease
DKL61_RS11655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DKL61_RS11660	COG0617	tRNA 3'-terminal CCA addition
DKL61_RS11675	COG2967	ApaG domain
DKL61_RS11690	COG0579	oxidoreductase
DKL61_RS11710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DKL61_RS11715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKL61_RS11720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DKL61_RS11725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DKL61_RS11735	COG0545	Peptidyl-prolyl cis-trans isomerase
DKL61_RS11825	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DKL61_RS11830	COG0582	viral genome integration into host DNA
DKL61_RS11855	COG3111	PFAM Bacterial OB fold (BOF) protein
DKL61_RS11860	COG0167	dihydroorotate dehydrogenase activity
DKL61_RS11865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKL61_RS11870	COG0084	hydrolase, TatD family'
DKL61_RS11895	COG1607	acyl-coa hydrolase
DKL61_RS11900	COG0181	hydroxymethylbilane synthase activity
DKL61_RS11920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKL61_RS11930	COG0471	metal ion transport
DKL61_RS11940	COG2814	Major facilitator Superfamily
DKL61_RS11955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DKL61_RS11965	COG0842	Transport permease protein
DKL61_RS11985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKL61_RS11990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DKL61_RS11995	COG0140	phosphoribosyl-ATP diphosphatase activity
DKL61_RS12025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKL61_RS12040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKL61_RS12045	COG0513	Belongs to the DEAD box helicase family
DKL61_RS12050	COG0084	hydrolase, TatD family'
DKL61_RS12055	COG1047	Peptidyl-prolyl cis-trans
DKL61_RS12060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DKL61_RS12065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DKL61_RS12070	COG0196	riboflavin kinase activity
DKL61_RS12075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKL61_RS12085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKL61_RS12090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DKL61_RS12095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKL61_RS12100	COG1660	Displays ATPase and GTPase activities
DKL61_RS12145	COG1741	Belongs to the pirin family
DKL61_RS12150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DKL61_RS12155	COG2252	PERMEase
DKL61_RS12160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKL61_RS12165	COG0513	Belongs to the DEAD box helicase family
DKL61_RS12180	COG0018	arginyl-trna synthetase
DKL61_RS12190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DKL61_RS12210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKL61_RS12215	COG0585	pseudouridine synthase activity
DKL61_RS12220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DKL61_RS12245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DKL61_RS12250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DKL61_RS12255	COG0730	response to heat
DKL61_RS12270	COG0463	Glycosyl transferase, family 2
DKL61_RS12290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DKL61_RS12310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKL61_RS12315	COG0739	heme binding
DKL61_RS12320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKL61_RS12325	COG2204	response regulator
DKL61_RS12330	COG3852	Histidine kinase
DKL61_RS12340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DKL61_RS12345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKL61_RS12350	COG1113	amino acid transport
DKL61_RS12365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKL61_RS12375	COG0583	DNA-binding transcription factor activity
DKL61_RS12390	COG1758	RNA polymerase activity
DKL61_RS12395	COG0194	GDP metabolic process
DKL61_RS12430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DKL61_RS12435	COG0606	chelatase, subunit chli
DKL61_RS12500	COG0606	chelatase, subunit chli
DKL61_RS12525	COG2192	nodulation
DKL61_RS12530	COG0826	peptidase U32
DKL61_RS12535	COG2755	lipolytic protein G-D-S-L family
DKL61_RS12535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKL61_RS12545	COG0583	DNA-binding transcription factor activity
DKL61_RS12555	COG1733	regulation of RNA biosynthetic process
DKL61_RS12570	COG1765	OsmC-like protein
DKL61_RS12575	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS12590	COG4771	TonB-dependent receptor
DKL61_RS12620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DKL61_RS12630	COG0004	ammonium transporteR
DKL61_RS12635	COG0347	Belongs to the P(II) protein family
DKL61_RS12645	COG0730	response to heat
DKL61_RS12650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DKL61_RS12650	COG0316	Belongs to the HesB IscA family
DKL61_RS12655	COG0739	heme binding
DKL61_RS12670	COG2183	response to ionizing radiation
DKL61_RS12680	COG0700	Nucleoside recognition
DKL61_RS12710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DKL61_RS12720	COG3180	Ammonia monooxygenase
DKL61_RS12735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKL61_RS12735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKL61_RS12740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKL61_RS12745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DKL61_RS12790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKL61_RS12790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKL61_RS12800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKL61_RS12810	COG5016	pyruvate
DKL61_RS12810	COG0511	ligase activity, forming carbon-carbon bonds
DKL61_RS12815	COG0439	Biotin carboxylase
DKL61_RS12830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKL61_RS12845	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS12860	COG1652	LysM domain
DKL61_RS12865	COG0242	peptide deformylase activity
DKL61_RS12870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DKL61_RS12875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DKL61_RS12910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKL61_RS12915	COG0742	ribosomal rna small subunit methyltransferase
DKL61_RS12935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DKL61_RS12950	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DKL61_RS12960	COG0848	biopolymer transport protein
DKL61_RS12980	COG1131	(ABC) transporter
DKL61_RS12990	COG1546	Belongs to the CinA family
DKL61_RS13000	COG2137	regulation of response to DNA damage stimulus
DKL61_RS13015	COG2234	aminopeptidase activity
DKL61_RS13035	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS13045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKL61_RS13050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKL61_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS13075	COG0697	spore germination
DKL61_RS13080	COG1047	Peptidyl-prolyl cis-trans
DKL61_RS13085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKL61_RS13110	COG1918	ferrous iron import across plasma membrane
DKL61_RS13125	COG1408	metallophosphoesterase
DKL61_RS13135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKL61_RS13150	COG1077	Cell shape determining protein MreB Mrl
DKL61_RS13155	COG1792	Involved in formation and maintenance of cell shape
DKL61_RS13165	COG0424	maF-like protein
DKL61_RS13170	COG1530	ribonuclease E activity
DKL61_RS13180	COG0335	large ribosomal subunit rRNA binding
DKL61_RS13185	COG0336	Belongs to the RNA methyltransferase TrmD family
DKL61_RS13190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKL61_RS13195	COG0228	four-way junction DNA binding
DKL61_RS13200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DKL61_RS13205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKL61_RS13215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DKL61_RS13230	COG1349	DNA-binding transcription factor activity
DKL61_RS13245	COG4208	sulfate ABC transporter
DKL61_RS13250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKL61_RS13265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DKL61_RS13270	COG0494	nUDIX hydrolase
DKL61_RS13285	COG1946	Acyl-CoA thioesterase
DKL61_RS13295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DKL61_RS13305	COG0316	Belongs to the HesB IscA family
DKL61_RS13315	COG0697	spore germination
DKL61_RS13320	COG0583	DNA-binding transcription factor activity
DKL61_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
DKL61_RS13330	COG3527	Alpha-acetolactate decarboxylase
DKL61_RS13335	COG3148	PFAM DTW domain containing protein
DKL61_RS13345	COG2271	Major facilitator Superfamily
DKL61_RS13350	COG1414	Transcriptional regulator
DKL61_RS13355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DKL61_RS13360	COG0778	Nitroreductase
DKL61_RS13370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DKL61_RS13380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DKL61_RS13405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKL61_RS13405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKL61_RS13410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKL61_RS13410	COG2755	lipolytic protein G-D-S-L family
DKL61_RS13420	COG0330	HflC and HflK could
DKL61_RS13425	COG0667	Aldo Keto reductase
DKL61_RS13445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKL61_RS13450	COG0602	queuosine metabolic process
DKL61_RS13455	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DKL61_RS13460	COG2885	chlorophyll binding
DKL61_RS13495	COG0824	Thioesterase
DKL61_RS13500	COG2255	four-way junction helicase activity
DKL61_RS13515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DKL61_RS13525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DKL61_RS13545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKL61_RS13565	COG2329	Antibiotic biosynthesis monooxygenase
DKL61_RS13570	COG1074	ATP-dependent DNA helicase activity
DKL61_RS13585	COG2153	protein acetylation
DKL61_RS13590	COG2995	paraquat-inducible protein a
DKL61_RS13595	COG2995	paraquat-inducible protein a
DKL61_RS13600	COG3008	intermembrane lipid transfer
DKL61_RS13610	COG1519	Transferase
DKL61_RS13625	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DKL61_RS13630	COG0537	adenosine 5'-monophosphoramidase activity
DKL61_RS13640	COG0642	Histidine kinase
DKL61_RS13655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKL61_RS13660	COG0589	response to stress
DKL61_RS13685	COG0714	Associated with various cellular activities
DKL61_RS13700	COG0049	tRNA binding
DKL61_RS13710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DKL61_RS13730	COG0081	regulation of translation
DKL61_RS13770	COG0825	malonyl-CoA metabolic process
DKL61_RS13775	COG0587	DNA-directed DNA polymerase activity
DKL61_RS13780	COG1575	Belongs to the MenA family. Type 1 subfamily
DKL61_RS13785	COG0625	glutathione transferase activity
DKL61_RS13790	COG0312	modulator of DNA gyrase
DKL61_RS13795	COG3028	Belongs to the UPF0307 family
DKL61_RS13805	COG0745	RESPONSE REGULATOR receiver
DKL61_RS13810	COG2205	protein histidine kinase activity
DKL61_RS13815	COG4452	Inner membrane protein CreD
DKL61_RS13850	COG3111	PFAM Bacterial OB fold (BOF) protein
DKL61_RS13855	COG3111	PFAM Bacterial OB fold (BOF) protein
DKL61_RS13860	COG0745	RESPONSE REGULATOR receiver
DKL61_RS13865	COG0642	Histidine kinase
DKL61_RS13875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DKL61_RS13895	COG1454	alcohol dehydrogenase
DKL61_RS13905	COG0477	Major facilitator Superfamily
DKL61_RS13910	COG3089	Belongs to the UPF0270 family
DKL61_RS13915	COG1295	ribonuclease BN
DKL61_RS13920	COG1393	Belongs to the ArsC family
DKL61_RS13940	COG3025	triphosphatase activity
DKL61_RS13945	COG0776	regulation of translation
DKL61_RS13955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKL61_RS13965	COG1132	(ABC) transporter
DKL61_RS13970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DKL61_RS13980	COG0513	Belongs to the DEAD box helicase family
DKL61_RS13985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKL61_RS13995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DKL61_RS14000	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DKL61_RS14000	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DKL61_RS14005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DKL61_RS14020	COG1214	PFAM Peptidase M22, glycoprotease
DKL61_RS14025	COG0563	adenylate kinase activity
DKL61_RS14035	COG3118	belongs to the thioredoxin family
DKL61_RS14040	COG1162	GTPase activity
DKL61_RS14045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKL61_RS14050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKL61_RS14050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKL61_RS14055	COG0802	atpase or kinase
DKL61_RS14060	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKL61_RS14080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKL61_RS14095	COG2885	chlorophyll binding
DKL61_RS14105	COG1011	Hydrolase
DKL61_RS14110	COG0494	nUDIX hydrolase
DKL61_RS14165	COG0742	ribosomal rna small subunit methyltransferase
DKL61_RS14170	COG0612	Peptidase, M16
DKL61_RS14175	COG0612	Peptidase, M16
DKL61_RS14180	COG0552	protein localization to endoplasmic reticulum
DKL61_RS14185	COG2884	Cell division ATP-binding protein ftsE
DKL61_RS14190	COG2177	Part of the ABC transporter FtsEX involved in
DKL61_RS14210	COG2239	Acts as a magnesium transporter
DKL61_RS14215	COG1045	serine acetyltransferase
DKL61_RS14230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DKL61_RS14245	COG0438	transferase activity, transferring glycosyl groups
DKL61_RS14250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKL61_RS14265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKL61_RS14270	COG0741	lytic transglycosylase activity
DKL61_RS14270	COG1388	LysM domain
DKL61_RS14275	COG1690	Belongs to the RtcB family
DKL61_RS14290	COG4650	regulator
DKL61_RS14305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DKL61_RS14310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKL61_RS14315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DKL61_RS14330	COG0200	Binds to the 23S rRNA
DKL61_RS14335	COG1841	ribosomal large subunit assembly
DKL61_RS14340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DKL61_RS14355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DKL61_RS14360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DKL61_RS14365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DKL61_RS14370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DKL61_RS14375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DKL61_RS14380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DKL61_RS14395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DKL61_RS14400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DKL61_RS14410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DKL61_RS14415	COG0089	rRNA binding
DKL61_RS14425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKL61_RS14435	COG0142	geranyltranstransferase activity
DKL61_RS14445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DKL61_RS14465	COG3151	Protein conserved in bacteria
DKL61_RS14470	COG0494	nUDIX hydrolase
DKL61_RS14485	COG2200	EAL domain
DKL61_RS14490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DKL61_RS14495	COG2166	iron-sulfur cluster assembly
DKL61_RS14510	COG4174	ABC transporter (Permease)
DKL61_RS14515	COG4239	(ABC) transporter, permease
DKL61_RS14520	COG4172	Belongs to the ABC transporter superfamily
DKL61_RS14535	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS14550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DKL61_RS14555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKL61_RS14560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DKL61_RS14585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DKL61_RS14595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DKL61_RS14620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DKL61_RS14625	COG0052	Belongs to the universal ribosomal protein uS2 family
DKL61_RS14650	COG0114	fumarate hydratase activity
DKL61_RS14680	COG0523	cobalamin synthesis protein
DKL61_RS14685	COG2879	small protein
DKL61_RS14700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKL61_RS14705	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DKL61_RS14725	COG3052	prosthetic group binding
DKL61_RS14730	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DKL61_RS14735	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKL61_RS14745	COG3493	citrate carrier protein
DKL61_RS14755	COG4565	transcriptional regulatory protein
DKL61_RS14765	COG3468	outer membrane autotransporter barrel domain protein
DKL61_RS14770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKL61_RS14775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKL61_RS14780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKL61_RS14785	COG3128	pkhd-type hydroxylase
DKL61_RS14795	COG4774	siderophore transport
DKL61_RS14825	COG0494	nUDIX hydrolase
DKL61_RS14830	COG0210	DNA helicase
DKL61_RS14850	COG0009	L-threonylcarbamoyladenylate synthase
DKL61_RS14855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DKL61_RS14860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DKL61_RS14865	COG0484	heat shock protein binding
DKL61_RS14870	COG0443	Heat shock 70 kDa protein
DKL61_RS14875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DKL61_RS14880	COG0504	CTP synthase activity
DKL61_RS14885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DKL61_RS14900	COG1794	racemase activity, acting on amino acids and derivatives
DKL61_RS14905	COG0277	FAD linked oxidase domain protein
DKL61_RS14910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKL61_RS14920	COG3338	carbonate dehydratase activity
DKL61_RS14925	COG0604	alcohol dehydrogenase
DKL61_RS14930	COG0583	DNA-binding transcription factor activity
DKL61_RS14955	COG1522	sequence-specific DNA binding
DKL61_RS14960	COG4974	Belongs to the 'phage' integrase family
DKL61_RS14975	COG0248	Ppx GppA phosphatase
DKL61_RS14980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DKL61_RS14990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKL61_RS14995	COG0590	tRNA wobble adenosine to inosine editing
DKL61_RS15000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DKL61_RS15015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DKL61_RS15030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKL61_RS15040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DKL61_RS15055	COG0456	acetyltransferase
DKL61_RS15060	COG1012	belongs to the aldehyde dehydrogenase family
DKL61_RS15105	COG0582	viral genome integration into host DNA
DKL61_RS15160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKL61_RS15200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKL61_RS15210	COG0107	imidazoleglycerol-phosphate synthase activity
DKL61_RS15235	COG1053	succinate dehydrogenase
DKL61_RS15285	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DKL61_RS15295	COG0210	DNA helicase
DKL61_RS15305	COG0546	phosphoglycolate phosphatase activity
DKL61_RS15320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKL61_RS15330	COG0009	L-threonylcarbamoyladenylate synthase
DKL61_RS15335	COG0613	PHP domain protein
DKL61_RS15340	COG2917	probably involved in intracellular septation
DKL61_RS15345	COG2350	Protein conserved in bacteria
DKL61_RS15350	COG0745	RESPONSE REGULATOR receiver
DKL61_RS15365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DKL61_RS15370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DKL61_RS15375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKL61_RS15380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DKL61_RS15385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKL61_RS15390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DKL61_RS15395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DKL61_RS15405	COG0356	it plays a direct role in the translocation of protons across the membrane
DKL61_RS15415	COG1475	DNA binding
DKL61_RS15420	COG1192	Involved in chromosome partitioning
DKL61_RS15440	COG2945	thiolester hydrolase activity
DKL61_RS15445	COG0180	Tryptophanyl-tRNA synthetase
DKL61_RS15450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKL61_RS15455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DKL61_RS15455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKL61_RS15460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKL61_RS15465	COG2011	ABC-type metal ion transport system permease component
DKL61_RS15495	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKL61_RS15515	COG1970	mechanosensitive ion channel activity
DKL61_RS15525	COG0477	Major facilitator Superfamily
DKL61_RS15550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DKL61_RS15565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane