locus-tag	class	description
HMPREF9231_RS00010	COG0592	DNA-directed DNA polymerase activity
HMPREF9231_RS00025	COG0187	DNA topoisomerase II activity
HMPREF9231_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9231_RS00040	COG1970	mechanosensitive ion channel activity
HMPREF9231_RS00060	COG0631	protein serine/threonine phosphatase activity
HMPREF9231_RS00070	COG0768	penicillin binding
HMPREF9231_RS00075	COG0515	serine threonine protein kinase
HMPREF9231_RS00115	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF9231_RS00130	COG0180	Tryptophanyl-tRNA synthetase
HMPREF9231_RS00140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF9231_RS00150	COG0701	Predicted permease
HMPREF9231_RS00160	COG1253	flavin adenine dinucleotide binding
HMPREF9231_RS00165	COG0783	Belongs to the Dps family
HMPREF9231_RS00180	COG2217	Heavy metal translocating P-type atpase
HMPREF9231_RS00200	COG1131	(ABC) transporter
HMPREF9231_RS00220	COG3177	Filamentation induced by cAMP protein fic
HMPREF9231_RS00250	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HMPREF9231_RS00255	COG0747	negative chemotaxis
HMPREF9231_RS00265	COG0444	Belongs to the ABC transporter superfamily
HMPREF9231_RS00270	COG4608	Belongs to the ABC transporter superfamily
HMPREF9231_RS00275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9231_RS00305	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9231_RS00310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF9231_RS00330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9231_RS00340	COG0400	carboxylic ester hydrolase activity
HMPREF9231_RS00345	COG0590	tRNA wobble adenosine to inosine editing
HMPREF9231_RS00345	COG0037	tRNA processing
HMPREF9231_RS00350	COG1609	Transcriptional regulator
HMPREF9231_RS00355	COG1129	ABC transporter
HMPREF9231_RS00360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9231_RS00365	COG1879	ABC-type sugar transport system periplasmic component
HMPREF9231_RS00370	COG1869	D-ribose catabolic process
HMPREF9231_RS00385	COG0366	Alpha amylase catalytic
HMPREF9231_RS00390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF9231_RS00420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF9231_RS00420	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9231_RS00420	COG0351	phosphomethylpyrimidine kinase
HMPREF9231_RS00460	COG0577	efflux transmembrane transporter activity
HMPREF9231_RS00480	COG1175	transmembrane transport
HMPREF9231_RS00485	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS00495	COG1609	Transcriptional regulator
HMPREF9231_RS00500	COG0436	Aminotransferase
HMPREF9231_RS00520	COG0778	Nitroreductase
HMPREF9231_RS00530	COG0588	phosphoglycerate mutase activity
HMPREF9231_RS00540	COG1609	Transcriptional regulator
HMPREF9231_RS00585	COG3657	addiction module killer protein
HMPREF9231_RS00590	COG0629	single-stranded DNA binding
HMPREF9231_RS00635	COG4974	Belongs to the 'phage' integrase family
HMPREF9231_RS00645	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF9231_RS00690	COG1373	ATPase (AAA superfamily
HMPREF9231_RS00700	COG3093	addiction module antidote protein HigA
HMPREF9231_RS00705	COG3549	Plasmid maintenance system killer
HMPREF9231_RS00710	COG3177	Filamentation induced by cAMP protein fic
HMPREF9231_RS00715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9231_RS00725	COG0738	Major facilitator superfamily
HMPREF9231_RS00730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9231_RS00745	COG2205	protein histidine kinase activity
HMPREF9231_RS00750	COG0745	RESPONSE REGULATOR receiver
HMPREF9231_RS00790	COG0672	)-iron permease
HMPREF9231_RS00795	COG3470	protein probably involved in high-affinity Fe2 transport
HMPREF9231_RS00805	COG0577	efflux transmembrane transporter activity
HMPREF9231_RS00815	COG1136	(ABC) transporter
HMPREF9231_RS00850	COG2204	response regulator
HMPREF9231_RS00865	COG2197	response regulator
HMPREF9231_RS00890	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF9231_RS00895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF9231_RS00900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF9231_RS00920	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9231_RS00935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HMPREF9231_RS00935	COG2755	lipolytic protein G-D-S-L family
HMPREF9231_RS00940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF9231_RS00950	COG0745	RESPONSE REGULATOR receiver
HMPREF9231_RS01060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF9231_RS01085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF9231_RS01090	COG0531	amino acid
HMPREF9231_RS01100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9231_RS01105	COG5006	permease, DMT superfamily
HMPREF9231_RS01125	COG1739	Uncharacterized protein family UPF0029
HMPREF9231_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9231_RS01150	COG1454	alcohol dehydrogenase
HMPREF9231_RS01200	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF9231_RS01310	COG1609	Transcriptional regulator
HMPREF9231_RS01320	COG1175	transmembrane transport
HMPREF9231_RS01325	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS01330	COG1554	hydrolase, family 65, central catalytic
HMPREF9231_RS01340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9231_RS01345	COG3250	beta-galactosidase activity
HMPREF9231_RS01350	COG2731	YhcH YjgK YiaL family protein
HMPREF9231_RS01360	COG1070	Carbohydrate kinase
HMPREF9231_RS01370	COG1129	ABC transporter
HMPREF9231_RS01375	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9231_RS01380	COG4214	carbohydrate transport
HMPREF9231_RS01425	COG1609	Transcriptional regulator
HMPREF9231_RS01450	COG1175	transmembrane transport
HMPREF9231_RS01455	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS01470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9231_RS01480	COG1268	BioY protein
HMPREF9231_RS01485	COG4770	biotin carboxylase activity
HMPREF9231_RS01490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF9231_RS01500	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF9231_RS01560	COG0681	Belongs to the peptidase S26 family
HMPREF9231_RS01565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF9231_RS01595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HMPREF9231_RS01675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF9231_RS01685	COG0006	proline dipeptidase activity
HMPREF9231_RS01690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF9231_RS01690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF9231_RS01705	COG0285	dihydrofolate synthase activity
HMPREF9231_RS01725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9231_RS01735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF9231_RS01740	COG2182	Extracellular solute-binding protein
HMPREF9231_RS01745	COG1175	transmembrane transport
HMPREF9231_RS01750	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS01755	COG1940	carbohydrate kinase activity
HMPREF9231_RS01760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF9231_RS01770	COG1396	sequence-specific DNA binding
HMPREF9231_RS01775	COG0542	response to heat
HMPREF9231_RS01785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF9231_RS01800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF9231_RS01825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9231_RS01880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF9231_RS01885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9231_RS01885	COG1522	sequence-specific DNA binding
HMPREF9231_RS01890	COG0477	Major facilitator Superfamily
HMPREF9231_RS01900	COG0742	ribosomal rna small subunit methyltransferase
HMPREF9231_RS01915	COG1837	Belongs to the UPF0109 family
HMPREF9231_RS01980	COG4115	mRNA cleavage
HMPREF9231_RS01995	COG0719	Fe-S assembly protein
HMPREF9231_RS02000	COG0396	ATPase activity
HMPREF9231_RS02005	COG1217	gtp-binding protein TYPA
HMPREF9231_RS02020	COG0287	Prephenate dehydrogenase
HMPREF9231_RS02060	COG2357	RelA SpoT domain protein
HMPREF9231_RS02080	COG3425	synthase
HMPREF9231_RS02090	COG0183	Belongs to the thiolase family
HMPREF9231_RS02175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HMPREF9231_RS02185	COG4166	transmembrane transport
HMPREF9231_RS02190	COG0601	transmembrane transport
HMPREF9231_RS02195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9231_RS02200	COG4172	Belongs to the ABC transporter superfamily
HMPREF9231_RS02205	COG0708	Exodeoxyribonuclease III
HMPREF9231_RS02225	COG3842	ATPase activity
HMPREF9231_RS02290	COG1191	sigma factor activity
HMPREF9231_RS02315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9231_RS02315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9231_RS02350	COG3409	Peptidoglycan-binding domain 1 protein
HMPREF9231_RS02395	COG4626	Terminase
HMPREF9231_RS02395	COG1802	Transcriptional regulator
HMPREF9231_RS02405	COG0740	serine-type endopeptidase activity
HMPREF9231_RS02500	COG0494	nUDIX hydrolase
HMPREF9231_RS02520	COG1395	domain, Protein
HMPREF9231_RS02535	COG1476	TRANSCRIPTIONal
HMPREF9231_RS02555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF9231_RS02585	COG1373	ATPase (AAA superfamily
HMPREF9231_RS02610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF9231_RS02615	COG1129	ABC transporter
HMPREF9231_RS02620	COG1122	ATPase activity
HMPREF9231_RS02630	COG4555	ABC transporter
HMPREF9231_RS02650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF9231_RS02660	COG1045	serine acetyltransferase
HMPREF9231_RS02675	COG1132	(ABC) transporter
HMPREF9231_RS02680	COG1122	ATPase activity
HMPREF9231_RS02685	COG1122	ATPase activity
HMPREF9231_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9231_RS02730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HMPREF9231_RS02735	COG1511	domain protein
HMPREF9231_RS02745	COG1454	alcohol dehydrogenase
HMPREF9231_RS02775	COG1316	TRANSCRIPTIONal
HMPREF9231_RS02785	COG1316	TRANSCRIPTIONal
HMPREF9231_RS02815	COG2205	protein histidine kinase activity
HMPREF9231_RS02820	COG0745	RESPONSE REGULATOR receiver
HMPREF9231_RS02830	COG1329	Transcriptional regulator
HMPREF9231_RS02845	COG0539	negative regulation of cytoplasmic translation
HMPREF9231_RS02855	COG0237	dephospho-CoA kinase activity
HMPREF9231_RS02875	COG0469	pyruvate kinase activity
HMPREF9231_RS02895	COG0799	negative regulation of ribosome biogenesis
HMPREF9231_RS02900	COG0406	alpha-ribazole phosphatase activity
HMPREF9231_RS02905	COG3279	Response regulator of the LytR AlgR family
HMPREF9231_RS02950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF9231_RS02955	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF9231_RS02960	COG1702	phosphate starvation-inducible protein PhoH
HMPREF9231_RS02990	COG1022	Amp-dependent synthetase and ligase
HMPREF9231_RS03025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9231_RS03050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF9231_RS03075	COG0024	Methionine aminopeptidase
HMPREF9231_RS03080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF9231_RS03085	COG2884	Cell division ATP-binding protein ftsE
HMPREF9231_RS03090	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF9231_RS03095	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9231_RS03095	COG3942	CHAP domain
HMPREF9231_RS03110	COG0765	amino acid transport
HMPREF9231_RS03150	COG0747	negative chemotaxis
HMPREF9231_RS03155	COG0601	transmembrane transport
HMPREF9231_RS03160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9231_RS03165	COG4172	Belongs to the ABC transporter superfamily
HMPREF9231_RS03180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9231_RS03190	COG0358	DNA primase activity
HMPREF9231_RS03195	COG2942	2-epimerase
HMPREF9231_RS03205	COG1122	ATPase activity
HMPREF9231_RS03240	COG3064	Membrane
HMPREF9231_RS03240	COG3583	domain protein
HMPREF9231_RS03240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF9231_RS03245	COG1940	carbohydrate kinase activity
HMPREF9231_RS03250	COG1940	carbohydrate kinase activity
HMPREF9231_RS03255	COG0028	Belongs to the TPP enzyme family
HMPREF9231_RS03260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMPREF9231_RS03270	COG2188	Transcriptional regulator
HMPREF9231_RS03285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF9231_RS03305	COG1136	(ABC) transporter
HMPREF9231_RS03310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF9231_RS03315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMPREF9231_RS03325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMPREF9231_RS03340	COG0151	Belongs to the GarS family
HMPREF9231_RS03355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9231_RS03380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF9231_RS03385	COG1058	Belongs to the CinA family
HMPREF9231_RS03385	COG1546	Belongs to the CinA family
HMPREF9231_RS03400	COG2137	regulation of response to DNA damage stimulus
HMPREF9231_RS03420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF9231_RS03435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF9231_RS03460	COG1862	Preprotein translocase
HMPREF9231_RS03490	COG1187	pseudouridine synthase activity
HMPREF9231_RS03520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMPREF9231_RS03525	COG1215	transferase activity, transferring glycosyl groups
HMPREF9231_RS03530	COG1064	alcohol dehydrogenase
HMPREF9231_RS03545	COG3634	alkyl hydroperoxide reductase activity
HMPREF9231_RS03570	COG1196	nuclear chromosome segregation
HMPREF9231_RS03585	COG1126	abc transporter atp-binding protein
HMPREF9231_RS03590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9231_RS03595	COG0765	amino acid transport
HMPREF9231_RS03600	COG0765	amino acid transport
HMPREF9231_RS03620	COG4581	dead DEAH box helicase
HMPREF9231_RS03665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9231_RS03675	COG0575	Belongs to the CDS family
HMPREF9231_RS03705	COG1022	Amp-dependent synthetase and ligase
HMPREF9231_RS03715	COG0516	GMP reductase activity
HMPREF9231_RS03730	COG0488	(ABC) transporter
HMPREF9231_RS03740	COG0436	Aminotransferase
HMPREF9231_RS03755	COG0560	Phosphoserine phosphatase
HMPREF9231_RS03780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF9231_RS03810	COG0730	response to heat
HMPREF9231_RS03815	COG0488	(ABC) transporter
HMPREF9231_RS03835	COG1396	sequence-specific DNA binding
HMPREF9231_RS03850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9231_RS03875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9231_RS03900	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF9231_RS03935	COG0167	dihydroorotate dehydrogenase activity
HMPREF9231_RS03940	COG0543	2 iron, 2 sulfur cluster binding
HMPREF9231_RS03950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF9231_RS03965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPREF9231_RS03990	COG0456	acetyltransferase
HMPREF9231_RS04000	COG0802	atpase or kinase
HMPREF9231_RS04045	COG1022	Amp-dependent synthetase and ligase
HMPREF9231_RS04065	COG0833	amino acid
HMPREF9231_RS04070	COG2860	membrane
HMPREF9231_RS04075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9231_RS04105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF9231_RS04115	COG1116	anion transmembrane transporter activity
HMPREF9231_RS04135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF9231_RS04145	COG2233	PERMEase
HMPREF9231_RS04150	COG3189	MarR family transcriptional regulator
HMPREF9231_RS04160	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF9231_RS04165	COG0012	GTP binding
HMPREF9231_RS04170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF9231_RS04180	COG4585	Histidine kinase
HMPREF9231_RS04185	COG2197	response regulator
HMPREF9231_RS04200	COG1136	(ABC) transporter
HMPREF9231_RS04200	COG0577	efflux transmembrane transporter activity
HMPREF9231_RS04205	COG1454	alcohol dehydrogenase
HMPREF9231_RS04215	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF9231_RS04230	COG3618	amidohydrolase
HMPREF9231_RS04235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9231_RS04245	COG1321	iron dependent repressor
HMPREF9231_RS04245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9231_RS04250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9231_RS04255	COG1121	(ABC) transporter
HMPREF9231_RS04275	COG0583	DNA-binding transcription factor activity
HMPREF9231_RS04330	COG1278	Cold shock
HMPREF9231_RS04335	COG2205	protein histidine kinase activity
HMPREF9231_RS04340	COG0745	RESPONSE REGULATOR receiver
HMPREF9231_RS04355	COG0459	protein refolding
HMPREF9231_RS04370	COG0714	Associated with various cellular activities
HMPREF9231_RS04410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9231_RS04460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF9231_RS04465	COG1882	Formate acetyltransferase
HMPREF9231_RS04470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HMPREF9231_RS04470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMPREF9231_RS04475	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9231_RS04480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9231_RS04485	COG2011	ABC-type metal ion transport system permease component
HMPREF9231_RS04500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9231_RS04525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9231_RS04580	COG0187	DNA topoisomerase II activity
HMPREF9231_RS04585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9231_RS04595	COG0142	geranyltranstransferase activity
HMPREF9231_RS04620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF9231_RS04685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF9231_RS04720	COG0857	belongs to the CobB CobQ family
HMPREF9231_RS04720	COG0280	phosphate acetyltransferase
HMPREF9231_RS04725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF9231_RS04740	COG1122	ATPase activity
HMPREF9231_RS04745	COG4721	ABC-type cobalt transport system, permease component
HMPREF9231_RS04780	COG1053	succinate dehydrogenase
HMPREF9231_RS04790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMPREF9231_RS04795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9231_RS04795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF9231_RS04810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF9231_RS04815	COG1122	ATPase activity
HMPREF9231_RS04845	COG4172	Belongs to the ABC transporter superfamily
HMPREF9231_RS04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9231_RS04870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMPREF9231_RS04890	COG0589	response to stress
HMPREF9231_RS04895	COG1388	LysM domain
HMPREF9231_RS04895	COG3103	Sh3 type 3 domain protein
HMPREF9231_RS04895	COG0791	NLP P60 protein
HMPREF9231_RS04900	COG1388	LysM domain
HMPREF9231_RS04900	COG3942	CHAP domain
HMPREF9231_RS04910	COG5002	protein histidine kinase activity
HMPREF9231_RS04915	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF9231_RS04925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF9231_RS04950	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF9231_RS04970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF9231_RS04975	COG2813	Specifically methylates the guanine in position
HMPREF9231_RS04980	COG1643	Atp-dependent helicase
HMPREF9231_RS05005	COG0587	DNA-directed DNA polymerase activity
HMPREF9231_RS05035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMPREF9231_RS05065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HMPREF9231_RS05075	COG4721	ABC-type cobalt transport system, permease component
HMPREF9231_RS05110	COG3480	Lon protease (S16) C-terminal proteolytic domain
HMPREF9231_RS05150	COG4172	Belongs to the ABC transporter superfamily
HMPREF9231_RS05155	COG4166	transmembrane transport
HMPREF9231_RS05160	COG0601	transmembrane transport
HMPREF9231_RS05165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9231_RS05185	COG1570	exodeoxyribonuclease VII activity
HMPREF9231_RS05250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9231_RS05260	COG0768	penicillin binding
HMPREF9231_RS05305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF9231_RS05315	COG1760	l-serine dehydratase
HMPREF9231_RS05320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9231_RS05330	COG1609	Transcriptional regulator
HMPREF9231_RS05340	COG1653	transport
HMPREF9231_RS05345	COG1175	transmembrane transport
HMPREF9231_RS05350	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS05380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9231_RS05385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF9231_RS05455	COG1132	(ABC) transporter
HMPREF9231_RS05460	COG1132	(ABC) transporter
HMPREF9231_RS05470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF9231_RS05470	COG1328	CTP reductase activity
HMPREF9231_RS05485	COG1349	DNA-binding transcription factor activity
HMPREF9231_RS05490	COG2814	Major facilitator Superfamily
HMPREF9231_RS05500	COG3118	belongs to the thioredoxin family
HMPREF9231_RS05515	COG1215	transferase activity, transferring glycosyl groups
HMPREF9231_RS05535	COG1442	glycosyl transferase family 8
HMPREF9231_RS05535	COG1216	Glycosyl transferase, family 2
HMPREF9231_RS05545	COG0463	Glycosyl transferase, family 2
HMPREF9231_RS05565	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF9231_RS05590	COG0488	(ABC) transporter
HMPREF9231_RS05595	COG0167	dihydroorotate dehydrogenase activity
HMPREF9231_RS05600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9231_RS05600	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPREF9231_RS05605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMPREF9231_RS05610	COG1770	oligopeptidase
HMPREF9231_RS05620	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF9231_RS05625	COG1803	Methylglyoxal synthase
HMPREF9231_RS05625	COG1597	lipid kinase activity
HMPREF9231_RS05635	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF9231_RS05655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF9231_RS05660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HMPREF9231_RS05665	COG0402	S-adenosylhomocysteine deaminase activity
HMPREF9231_RS05675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF9231_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9231_RS05690	COG1126	abc transporter atp-binding protein
HMPREF9231_RS05695	COG0656	L-ascorbic acid biosynthetic process
HMPREF9231_RS05720	COG4214	carbohydrate transport
HMPREF9231_RS05735	COG1846	Transcriptional regulator
HMPREF9231_RS05735	COG1940	carbohydrate kinase activity
HMPREF9231_RS05740	COG1129	ABC transporter
HMPREF9231_RS05790	COG2252	PERMEase
HMPREF9231_RS05825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF9231_RS05830	COG0196	riboflavin kinase activity
HMPREF9231_RS05860	COG3579	cysteine-type endopeptidase activity
HMPREF9231_RS05870	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF9231_RS05875	COG1496	oxidoreductase activity
HMPREF9231_RS05880	COG0667	Aldo Keto reductase
HMPREF9231_RS05895	COG0586	Pfam SNARE associated Golgi protein
HMPREF9231_RS05910	COG1357	PFAM Pentapeptide repeats (8 copies)
HMPREF9231_RS05910	COG0515	serine threonine protein kinase
HMPREF9231_RS05915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9231_RS05940	COG0436	Aminotransferase
HMPREF9231_RS05965	COG1530	ribonuclease E activity
HMPREF9231_RS05990	COG0083	homoserine kinase activity
HMPREF9231_RS05995	COG0460	homoserine dehydrogenase
HMPREF9231_RS06020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9231_RS06025	COG1121	(ABC) transporter
HMPREF9231_RS06050	COG1335	isochorismatase
HMPREF9231_RS06075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HMPREF9231_RS06085	COG3265	gluconokinase activity
HMPREF9231_RS06105	COG0084	hydrolase, TatD family'
HMPREF9231_RS06110	COG1132	(ABC) transporter
HMPREF9231_RS06115	COG1132	(ABC) transporter
HMPREF9231_RS06135	COG0601	transmembrane transport
HMPREF9231_RS06140	COG3579	cysteine-type endopeptidase activity
HMPREF9231_RS06190	COG1881	PFAM PEBP family protein
HMPREF9231_RS06205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF9231_RS06205	COG1754	DNA topoisomerase type I activity
HMPREF9231_RS06215	COG1260	myo-inositol-1-phosphate synthase
HMPREF9231_RS06220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9231_RS06225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9231_RS06230	COG0789	Transcriptional regulator
HMPREF9231_RS06235	COG0484	heat shock protein binding
HMPREF9231_RS06255	COG2022	thiamine diphosphate biosynthetic process
HMPREF9231_RS06265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF9231_RS06280	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS06285	COG1175	transmembrane transport
HMPREF9231_RS06295	COG1609	Transcriptional regulator
HMPREF9231_RS06305	COG0366	Alpha amylase catalytic
HMPREF9231_RS06315	COG1175	transmembrane transport
HMPREF9231_RS06320	COG3833	ABC-type maltose transport systems, permease component
HMPREF9231_RS06325	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF9231_RS06360	COG1113	amino acid transport
HMPREF9231_RS06370	COG1136	(ABC) transporter
HMPREF9231_RS06370	COG0577	efflux transmembrane transporter activity
HMPREF9231_RS06450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF9231_RS06460	COG0191	fructose-bisphosphate aldolase activity
HMPREF9231_RS06465	COG0287	Prephenate dehydrogenase
HMPREF9231_RS06465	COG1605	Chorismate mutase
HMPREF9231_RS06470	COG1522	sequence-specific DNA binding
HMPREF9231_RS06520	COG1131	(ABC) transporter
HMPREF9231_RS06550	COG1131	(ABC) transporter
HMPREF9231_RS06560	COG0179	Fumarylacetoacetate (FAA) hydrolase
HMPREF9231_RS06565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF9231_RS06575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9231_RS06580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF9231_RS06635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF9231_RS06640	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9231_RS06645	COG0534	Mate efflux family protein
HMPREF9231_RS06670	COG1653	transport
HMPREF9231_RS06680	COG0395	ABC-type sugar transport system, permease component
HMPREF9231_RS06685	COG3250	beta-galactosidase activity
HMPREF9231_RS06700	COG4154	Belongs to the RbsD FucU family
HMPREF9231_RS06710	COG3842	ATPase activity
HMPREF9231_RS06715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HMPREF9231_RS06715	COG0515	serine threonine protein kinase
HMPREF9231_RS06735	COG3583	domain protein
HMPREF9231_RS06750	COG0617	tRNA 3'-terminal CCA addition
HMPREF9231_RS06775	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9231_RS06780	COG1475	DNA binding
HMPREF9231_RS06785	COG1192	Involved in chromosome partitioning
HMPREF9231_RS06795	COG1847	R3H domain protein