locus-tag	class	description
J421_RS00035	COG1396	sequence-specific DNA binding
J421_RS00150	COG1396	sequence-specific DNA binding
J421_RS00260	COG1396	sequence-specific DNA binding
J421_RS00290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J421_RS00295	COG1611	Belongs to the LOG family
J421_RS00325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS00330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS00335	COG0567	Dehydrogenase, E1 component
J421_RS00340	COG2205	protein histidine kinase activity
J421_RS00345	COG2205	protein histidine kinase activity
J421_RS00355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J421_RS00360	COG0784	Response regulator, receiver
J421_RS00360	COG2198	Histidine kinase
J421_RS00360	COG2205	protein histidine kinase activity
J421_RS00365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J421_RS00365	COG0116	Belongs to the methyltransferase superfamily
J421_RS00395	COG0514	ATP-dependent DNA helicase (RecQ)
J421_RS00400	COG0668	transmembrane transport
J421_RS00405	COG1764	response to oxidative stress
J421_RS00475	COG1739	Uncharacterized protein family UPF0029
J421_RS00495	COG1960	acyl-CoA dehydrogenase activity
J421_RS00515	COG0438	transferase activity, transferring glycosyl groups
J421_RS00540	COG0392	lysyltransferase activity
J421_RS00540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J421_RS00550	COG2205	protein histidine kinase activity
J421_RS00570	COG2203	Gaf domain
J421_RS00570	COG4585	Histidine kinase
J421_RS00575	COG2197	response regulator
J421_RS00580	COG1846	Transcriptional regulator
J421_RS00625	COG0438	transferase activity, transferring glycosyl groups
J421_RS00635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J421_RS00635	COG2755	lipolytic protein G-D-S-L family
J421_RS00650	COG1215	transferase activity, transferring glycosyl groups
J421_RS00695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J421_RS00715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J421_RS00735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J421_RS00765	COG2201	protein-glutamate methylesterase activity
J421_RS00780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J421_RS00785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J421_RS00790	COG0835	chemotaxis
J421_RS00795	COG0840	transmembrane signaling receptor activity
J421_RS00800	COG0643	Histidine kinase
J421_RS00800	COG2198	Histidine kinase
J421_RS00810	COG2205	protein histidine kinase activity
J421_RS00810	COG2198	Histidine kinase
J421_RS00810	COG0784	Response regulator, receiver
J421_RS00820	COG0745	RESPONSE REGULATOR receiver
J421_RS00840	COG1516	flagellar protein fliS
J421_RS00860	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
J421_RS00870	COG2204	response regulator
J421_RS00875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J421_RS00890	COG1196	nuclear chromosome segregation
J421_RS00890	COG0741	lytic transglycosylase activity
J421_RS00890	COG0739	heme binding
J421_RS00895	COG3590	peptidase
J421_RS00905	COG1558	bacterial-type flagellum-dependent cell motility
J421_RS00915	COG1677	Flagellar hook-basal body complex protein FliE
J421_RS00920	COG1766	The M ring may be actively involved in energy transduction
J421_RS00925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J421_RS00935	COG1157	protein secretion by the type III secretion system
J421_RS00965	COG1749	Flagellar hook protein flgE
J421_RS00980	COG1776	CheC inhibitor of MCP methylation
J421_RS00980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J421_RS00985	COG1338	Plays a role in the flagellum-specific transport system
J421_RS00990	COG0561	phosphatase activity
J421_RS01000	COG1987	bacterial-type flagellum assembly
J421_RS01010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J421_RS01015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J421_RS01020	COG1419	protein localization to endoplasmic reticulum
J421_RS01030	COG1191	sigma factor activity
J421_RS01055	COG0577	efflux transmembrane transporter activity
J421_RS01055	COG1136	(ABC) transporter
J421_RS01060	COG0657	acetylesterase activity
J421_RS01065	COG4787	bacterial-type flagellum-dependent cell motility
J421_RS01080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J421_RS01085	COG1706	bacterial-type flagellum-dependent cell motility
J421_RS01100	COG4786	Flagellar basal body rod
J421_RS01100	COG1256	bacterial-type flagellum assembly
J421_RS01130	COG0515	serine threonine protein kinase
J421_RS01130	COG2815	serine threonine protein kinase
J421_RS01135	COG2815	serine threonine protein kinase
J421_RS01135	COG0515	serine threonine protein kinase
J421_RS01145	COG1695	Transcriptional regulator
J421_RS01170	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
J421_RS01180	COG1131	(ABC) transporter
J421_RS01265	COG1902	pentaerythritol trinitrate reductase activity
J421_RS01275	COG0405	Gamma-glutamyltransferase
J421_RS01280	COG2755	lipolytic protein G-D-S-L family
J421_RS01280	COG0657	acetylesterase activity
J421_RS01295	COG1136	(ABC) transporter
J421_RS01295	COG0577	efflux transmembrane transporter activity
J421_RS01325	COG2205	protein histidine kinase activity
J421_RS01330	COG4251	negative regulation of phosphorylation
J421_RS01355	COG0791	NLP P60 protein
J421_RS01355	COG0741	lytic transglycosylase activity
J421_RS01365	COG2197	response regulator
J421_RS01385	COG4191	Histidine kinase
J421_RS01390	COG2204	response regulator
J421_RS01405	COG1136	(ABC) transporter
J421_RS01405	COG0577	efflux transmembrane transporter activity
J421_RS01410	COG1136	(ABC) transporter
J421_RS01410	COG0577	efflux transmembrane transporter activity
J421_RS01415	COG0577	efflux transmembrane transporter activity
J421_RS01415	COG1136	(ABC) transporter
J421_RS01420	COG0577	efflux transmembrane transporter activity
J421_RS01420	COG1136	(ABC) transporter
J421_RS01425	COG0577	efflux transmembrane transporter activity
J421_RS01425	COG1136	(ABC) transporter
J421_RS01430	COG0577	efflux transmembrane transporter activity
J421_RS01430	COG1136	(ABC) transporter
J421_RS01440	COG0577	efflux transmembrane transporter activity
J421_RS01445	COG0577	efflux transmembrane transporter activity
J421_RS01445	COG1136	(ABC) transporter
J421_RS01450	COG1136	(ABC) transporter
J421_RS01450	COG4591	ABC-type transport system involved in lipoprotein release permease component
J421_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J421_RS01470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J421_RS01475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J421_RS01500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J421_RS01505	COG1845	cytochrome c oxidase, subunit III
J421_RS01505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J421_RS01515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS01545	COG1595	DNA-templated transcription, initiation
J421_RS01585	COG2311	Membrane
J421_RS01600	COG3387	PFAM Glycoside hydrolase 15-related
J421_RS01610	COG2234	aminopeptidase activity
J421_RS01620	COG0667	Aldo Keto reductase
J421_RS01625	COG0436	Aminotransferase
J421_RS01630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J421_RS01635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J421_RS01645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J421_RS01665	COG1136	(ABC) transporter
J421_RS01665	COG0577	efflux transmembrane transporter activity
J421_RS01670	COG2205	protein histidine kinase activity
J421_RS01710	COG0745	RESPONSE REGULATOR receiver
J421_RS01715	COG2205	protein histidine kinase activity
J421_RS01725	COG4771	TonB-dependent receptor
J421_RS01760	COG1129	ABC transporter
J421_RS01770	COG1172	Belongs to the binding-protein-dependent transport system permease family
J421_RS01780	COG2755	lipolytic protein G-D-S-L family
J421_RS01785	COG1629	transport
J421_RS01785	COG4206	TonB-dependent receptor
J421_RS01790	COG4124	Belongs to the glycosyl hydrolase 26 family
J421_RS01795	COG0702	epimerase
J421_RS01800	COG1629	transport
J421_RS01805	COG1846	Transcriptional regulator
J421_RS01805	COG1940	carbohydrate kinase activity
J421_RS01810	COG3291	Pkd domain containing protein
J421_RS01820	COG1501	Belongs to the glycosyl hydrolase 31 family
J421_RS01825	COG0531	amino acid
J421_RS01835	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS01845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J421_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS01855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
J421_RS01885	COG0800	Aldolase
J421_RS01890	COG0246	Mannitol dehydrogenase
J421_RS01895	COG2721	sulfolactate sulfo-lyase activity
J421_RS01905	COG1904	glucuronate isomerase
J421_RS01910	COG1940	carbohydrate kinase activity
J421_RS01915	COG2234	aminopeptidase activity
J421_RS01920	COG0028	Belongs to the TPP enzyme family
J421_RS01925	COG0577	efflux transmembrane transporter activity
J421_RS01925	COG1136	(ABC) transporter
J421_RS01960	COG1301	dicarboxylic acid transport
J421_RS01965	COG0577	efflux transmembrane transporter activity
J421_RS01965	COG1136	(ABC) transporter
J421_RS01990	COG0784	Response regulator, receiver
J421_RS01990	COG2198	Histidine kinase
J421_RS01990	COG5002	protein histidine kinase activity
J421_RS02035	COG0577	efflux transmembrane transporter activity
J421_RS02035	COG1136	(ABC) transporter
J421_RS02040	COG0583	DNA-binding transcription factor activity
J421_RS02065	COG0840	transmembrane signaling receptor activity
J421_RS02085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J421_RS02090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J421_RS02110	COG2819	hydrolase of the alpha beta superfamily
J421_RS02115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J421_RS02120	COG1181	Belongs to the D-alanine--D-alanine ligase family
J421_RS02145	COG1136	(ABC) transporter
J421_RS02145	COG0577	efflux transmembrane transporter activity
J421_RS02160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J421_RS02200	COG2304	oxidoreductase activity
J421_RS02220	COG0174	glutamine synthetase
J421_RS02235	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
J421_RS02245	COG3852	Histidine kinase
J421_RS02250	COG0745	RESPONSE REGULATOR receiver
J421_RS02285	COG3852	Histidine kinase
J421_RS02295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J421_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS02320	COG0793	Belongs to the peptidase S41A family
J421_RS02325	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS02325	COG1506	peptidase
J421_RS02355	COG2010	Cytochrome c
J421_RS02380	COG2815	serine threonine protein kinase
J421_RS02380	COG0515	serine threonine protein kinase
J421_RS02405	COG0546	phosphoglycolate phosphatase activity
J421_RS02415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J421_RS02425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J421_RS02440	COG2205	protein histidine kinase activity
J421_RS02440	COG2198	Histidine kinase
J421_RS02440	COG0784	Response regulator, receiver
J421_RS02460	COG1172	Belongs to the binding-protein-dependent transport system permease family
J421_RS02465	COG1879	ABC-type sugar transport system periplasmic component
J421_RS02480	COG3481	metal-dependent phosphohydrolase, HD sub domain
J421_RS02490	COG1278	Cold shock
J421_RS02510	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J421_RS02560	COG0545	Peptidyl-prolyl cis-trans isomerase
J421_RS02590	COG0714	Associated with various cellular activities
J421_RS02645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J421_RS02650	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
J421_RS02680	COG0733	neurotransmitter:sodium symporter activity
J421_RS02690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J421_RS02730	COG4122	O-methyltransferase activity
J421_RS02760	COG0793	Belongs to the peptidase S41A family
J421_RS02800	COG1472	Belongs to the glycosyl hydrolase 3 family
J421_RS02810	COG0667	Aldo Keto reductase
J421_RS02825	COG1271	oxidase subunit
J421_RS02830	COG4447	cellulose binding
J421_RS02845	COG2312	Erythromycin esterase
J421_RS02870	COG4946	Tricorn protease homolog
J421_RS02870	COG1506	peptidase
J421_RS02870	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS02885	COG0577	efflux transmembrane transporter activity
J421_RS02965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS02975	COG2815	serine threonine protein kinase
J421_RS02975	COG0515	serine threonine protein kinase
J421_RS02980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J421_RS02985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J421_RS02995	COG1136	(ABC) transporter
J421_RS02995	COG0577	efflux transmembrane transporter activity
J421_RS03035	COG0346	lactoylglutathione lyase activity
J421_RS03040	COG1595	DNA-templated transcription, initiation
J421_RS03090	COG1858	cytochrome C peroxidase
J421_RS03110	COG0515	serine threonine protein kinase
J421_RS03115	COG2815	serine threonine protein kinase
J421_RS03115	COG0515	serine threonine protein kinase
J421_RS03135	COG2815	serine threonine protein kinase
J421_RS03135	COG0515	serine threonine protein kinase
J421_RS03150	COG0346	lactoylglutathione lyase activity
J421_RS03180	COG0577	efflux transmembrane transporter activity
J421_RS03180	COG1136	(ABC) transporter
J421_RS03215	COG4941	Belongs to the sigma-70 factor family
J421_RS03235	COG3795	YCII-related domain
J421_RS03255	COG1136	(ABC) transporter
J421_RS03255	COG0577	efflux transmembrane transporter activity
J421_RS03280	COG0039	L-malate dehydrogenase activity
J421_RS03295	COG0154	amidase activity
J421_RS03380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J421_RS03385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J421_RS03400	COG2072	flavoprotein involved in K transport
J421_RS03405	COG2197	response regulator
J421_RS03415	COG2234	aminopeptidase activity
J421_RS03425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J421_RS03465	COG0778	Nitroreductase
J421_RS03475	COG1136	(ABC) transporter
J421_RS03475	COG0577	efflux transmembrane transporter activity
J421_RS03480	COG2264	protein methyltransferase activity
J421_RS03485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J421_RS03510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J421_RS03515	COG3119	arylsulfatase activity
J421_RS03520	COG0577	efflux transmembrane transporter activity
J421_RS03530	COG2816	NAD+ diphosphatase activity
J421_RS03540	COG0477	Major facilitator Superfamily
J421_RS03560	COG0667	Aldo Keto reductase
J421_RS03575	COG2205	protein histidine kinase activity
J421_RS03580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J421_RS03585	COG4251	negative regulation of phosphorylation
J421_RS03615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J421_RS03635	COG3275	phosphorelay sensor kinase activity
J421_RS03665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J421_RS03680	COG1228	amidohydrolase
J421_RS03685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J421_RS03695	COG2133	pyrroloquinoline quinone binding
J421_RS03715	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J421_RS03725	COG0673	inositol 2-dehydrogenase activity
J421_RS03740	COG1505	serine-type exopeptidase activity
J421_RS03780	COG0515	serine threonine protein kinase
J421_RS03785	COG2124	cytochrome p450
J421_RS03790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J421_RS03795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J421_RS03800	COG0363	glucosamine-6-phosphate deaminase activity
J421_RS03825	COG0612	Peptidase, M16
J421_RS03840	COG2234	aminopeptidase activity
J421_RS03840	COG4935	Belongs to the peptidase S8 family
J421_RS03865	COG2321	neutral zinc metallopeptidase
J421_RS03875	COG0438	transferase activity, transferring glycosyl groups
J421_RS03890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J421_RS03905	COG3275	phosphorelay sensor kinase activity
J421_RS03910	COG3279	Response regulator of the LytR AlgR family
J421_RS03915	COG2205	protein histidine kinase activity
J421_RS03930	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS03930	COG1506	peptidase
J421_RS03955	COG1404	Belongs to the peptidase S8 family
J421_RS03960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J421_RS03965	COG0438	transferase activity, transferring glycosyl groups
J421_RS04015	COG4206	TonB-dependent receptor
J421_RS04025	COG2423	ornithine cyclodeaminase activity
J421_RS04065	COG1454	alcohol dehydrogenase
J421_RS04105	COG0400	carboxylic ester hydrolase activity
J421_RS04110	COG2514	catechol 2,3-dioxygenase activity
J421_RS04115	COG2259	Doxx family
J421_RS04125	COG0076	glutamate decarboxylase activity
J421_RS04140	COG2204	response regulator
J421_RS04155	COG2259	Doxx family
J421_RS04200	COG0438	transferase activity, transferring glycosyl groups
J421_RS04215	COG2226	methyltransferase
J421_RS04225	COG2226	methyltransferase
J421_RS04235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J421_RS04245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J421_RS04270	COG0110	maltose O-acetyltransferase activity
J421_RS04275	COG0438	transferase activity, transferring glycosyl groups
J421_RS04290	COG0346	lactoylglutathione lyase activity
J421_RS04320	COG0673	inositol 2-dehydrogenase activity
J421_RS04335	COG0438	transferase activity, transferring glycosyl groups
J421_RS04360	COG1215	transferase activity, transferring glycosyl groups
J421_RS04405	COG4993	Dehydrogenase
J421_RS04430	COG0515	serine threonine protein kinase
J421_RS04430	COG2815	serine threonine protein kinase
J421_RS04435	COG3622	Belongs to the hyi family
J421_RS04465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J421_RS04515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J421_RS04570	COG0612	Peptidase, M16
J421_RS04575	COG0612	Peptidase, M16
J421_RS04625	COG3300	MHYT domain
J421_RS04625	COG5001	Diguanylate cyclase
J421_RS04635	COG0612	Peptidase, M16
J421_RS04650	COG0784	Response regulator, receiver
J421_RS04670	COG5002	protein histidine kinase activity
J421_RS04670	COG0784	Response regulator, receiver
J421_RS04730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J421_RS04735	COG1695	Transcriptional regulator
J421_RS04745	COG3540	Alkaline phosphatase
J421_RS04760	COG2162	N-hydroxyarylamine O-acetyltransferase activity
J421_RS04770	COG0583	DNA-binding transcription factor activity
J421_RS04775	COG2855	membrane
J421_RS04790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J421_RS04845	COG3119	arylsulfatase activity
J421_RS04860	COG1297	OPT oligopeptide transporter protein
J421_RS04950	COG4221	oxidoreductase activity
J421_RS04955	COG2814	Major facilitator Superfamily
J421_RS04965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J421_RS04980	COG0557	exoribonuclease II activity
J421_RS04985	COG2326	polyphosphate kinase activity
J421_RS04990	COG0494	nUDIX hydrolase
J421_RS05020	COG0741	lytic transglycosylase activity
J421_RS05020	COG0739	heme binding
J421_RS05020	COG1196	nuclear chromosome segregation
J421_RS05035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J421_RS05050	COG3590	peptidase
J421_RS05060	COG3279	Response regulator of the LytR AlgR family
J421_RS05065	COG3275	phosphorelay sensor kinase activity
J421_RS05080	COG0577	efflux transmembrane transporter activity
J421_RS05135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J421_RS05145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J421_RS05180	COG2815	serine threonine protein kinase
J421_RS05180	COG0515	serine threonine protein kinase
J421_RS05195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J421_RS05215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J421_RS05220	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J421_RS05225	COG2205	protein histidine kinase activity
J421_RS05250	COG4221	oxidoreductase activity
J421_RS05255	COG1881	PFAM PEBP family protein
J421_RS05275	COG1196	nuclear chromosome segregation
J421_RS05275	COG0741	lytic transglycosylase activity
J421_RS05275	COG0739	heme binding
J421_RS05295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J421_RS05310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J421_RS05315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J421_RS05320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J421_RS05330	COG0706	membrane insertase activity
J421_RS05335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J421_RS05340	COG0594	ribonuclease P activity
J421_RS05350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J421_RS05355	COG0592	DNA-directed DNA polymerase activity
J421_RS05360	COG1660	Displays ATPase and GTPase activities
J421_RS05365	COG1082	Xylose isomerase domain protein TIM barrel
J421_RS05390	COG1501	Belongs to the glycosyl hydrolase 31 family
J421_RS05395	COG3795	YCII-related domain
J421_RS05400	COG2314	TM2 domain
J421_RS05405	COG0577	efflux transmembrane transporter activity
J421_RS05405	COG1136	(ABC) transporter
J421_RS05500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J421_RS05505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J421_RS05505	COG1648	precorrin-2 dehydrogenase activity
J421_RS05510	COG4993	Dehydrogenase
J421_RS05535	COG1132	(ABC) transporter
J421_RS05550	COG0534	Mate efflux family protein
J421_RS05625	COG0577	efflux transmembrane transporter activity
J421_RS05630	COG2211	Major facilitator Superfamily
J421_RS05640	COG0673	inositol 2-dehydrogenase activity
J421_RS05680	COG2205	protein histidine kinase activity
J421_RS05680	COG2202	Pas domain
J421_RS05715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J421_RS05720	COG2205	protein histidine kinase activity
J421_RS05720	COG2202	Pas domain
J421_RS05745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J421_RS05745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J421_RS05750	COG4968	Prepilin-type N-terminal cleavage methylation domain
J421_RS05805	COG0445	tRNA wobble uridine modification
J421_RS05825	COG1475	DNA binding
J421_RS05835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J421_RS05850	COG1595	DNA-templated transcription, initiation
J421_RS05865	COG3845	ABC transporter
J421_RS05880	COG4603	Belongs to the binding-protein-dependent transport system permease family
J421_RS05885	COG1079	Belongs to the binding-protein-dependent transport system permease family
J421_RS05905	COG0429	hydrolase of the alpha beta-hydrolase fold
J421_RS05940	COG4771	TonB-dependent receptor
J421_RS05945	COG0702	epimerase
J421_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS05970	COG2271	Major facilitator Superfamily
J421_RS05975	COG1312	Catalyzes the dehydration of D-mannonate
J421_RS05985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
J421_RS05990	COG2814	Major facilitator Superfamily
J421_RS06000	COG0275	rRNA processing
J421_RS06065	COG2205	protein histidine kinase activity
J421_RS06070	COG1301	dicarboxylic acid transport
J421_RS06095	COG1393	Belongs to the ArsC family
J421_RS06105	COG4206	TonB-dependent receptor
J421_RS06115	COG3275	phosphorelay sensor kinase activity
J421_RS06135	COG0515	serine threonine protein kinase
J421_RS06145	COG4993	Dehydrogenase
J421_RS06155	COG0488	(ABC) transporter
J421_RS06165	COG0488	(ABC) transporter
J421_RS06185	COG0515	serine threonine protein kinase
J421_RS06245	COG4941	Belongs to the sigma-70 factor family
J421_RS06260	COG3795	YCII-related domain
J421_RS06280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J421_RS06295	COG0741	lytic transglycosylase activity
J421_RS06295	COG1388	LysM domain
J421_RS06310	COG0140	phosphoribosyl-ATP diphosphatase activity
J421_RS06310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J421_RS06325	COG0107	imidazoleglycerol-phosphate synthase activity
J421_RS06330	COG0131	Imidazoleglycerol-phosphate dehydratase
J421_RS06335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J421_RS06340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J421_RS06350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J421_RS06355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J421_RS06375	COG4294	response to UV
J421_RS06385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J421_RS06385	COG1793	dna ligase
J421_RS06415	COG1793	dna ligase
J421_RS06415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J421_RS06430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J421_RS06435	COG1629	transport
J421_RS06445	COG1136	(ABC) transporter
J421_RS06445	COG0577	efflux transmembrane transporter activity
J421_RS06480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J421_RS06505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS06525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J421_RS06535	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS06585	COG1136	(ABC) transporter
J421_RS06585	COG0577	efflux transmembrane transporter activity
J421_RS06590	COG1136	(ABC) transporter
J421_RS06590	COG0577	efflux transmembrane transporter activity
J421_RS06600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J421_RS06605	COG0165	Argininosuccinate lyase
J421_RS06610	COG0137	argininosuccinate synthase activity
J421_RS06620	COG1438	arginine binding
J421_RS06635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J421_RS06645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J421_RS06655	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS06655	COG1506	peptidase
J421_RS06665	COG2205	protein histidine kinase activity
J421_RS06665	COG2202	Pas domain
J421_RS06670	COG2205	protein histidine kinase activity
J421_RS06670	COG2202	Pas domain
J421_RS06675	COG0596	Alpha beta hydrolase
J421_RS06750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J421_RS06765	COG0577	efflux transmembrane transporter activity
J421_RS06765	COG1136	(ABC) transporter
J421_RS06780	COG2814	Major facilitator Superfamily
J421_RS06800	COG3275	phosphorelay sensor kinase activity
J421_RS06805	COG3279	Response regulator of the LytR AlgR family
J421_RS06815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS06820	COG1136	(ABC) transporter
J421_RS06820	COG0577	efflux transmembrane transporter activity
J421_RS06845	COG1506	peptidase
J421_RS06845	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS06850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J421_RS06885	COG3142	Participates in the control of copper homeostasis
J421_RS06895	COG1228	amidohydrolase
J421_RS06920	COG2202	Pas domain
J421_RS06920	COG2205	protein histidine kinase activity
J421_RS06930	COG2234	aminopeptidase activity
J421_RS06955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J421_RS06960	COG2234	aminopeptidase activity
J421_RS06965	COG0745	RESPONSE REGULATOR receiver
J421_RS06970	COG5002	protein histidine kinase activity
J421_RS06990	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS07000	COG1201	RNA secondary structure unwinding
J421_RS07005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J421_RS07040	COG1231	oxidoreductase activity
J421_RS07045	COG0297	glycogen (starch) synthase activity
J421_RS07050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J421_RS07055	COG0577	efflux transmembrane transporter activity
J421_RS07060	COG0577	efflux transmembrane transporter activity
J421_RS07150	COG0515	serine threonine protein kinase
J421_RS07150	COG2815	serine threonine protein kinase
J421_RS07225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J421_RS07240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J421_RS07250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J421_RS07255	COG2197	response regulator
J421_RS07260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS07265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS07270	COG1132	(ABC) transporter
J421_RS07310	COG0288	reversible hydration of carbon dioxide
J421_RS07360	COG0531	amino acid
J421_RS07380	COG0577	efflux transmembrane transporter activity
J421_RS07380	COG1136	(ABC) transporter
J421_RS07395	COG2234	aminopeptidase activity
J421_RS07400	COG0577	efflux transmembrane transporter activity
J421_RS07400	COG1136	(ABC) transporter
J421_RS07405	COG0745	RESPONSE REGULATOR receiver
J421_RS07410	COG5002	protein histidine kinase activity
J421_RS07420	COG0726	polysaccharide deacetylase
J421_RS07425	COG1013	pyruvate-flavodoxin oxidoreductase activity
J421_RS07430	COG0674	pyruvate-flavodoxin oxidoreductase activity
J421_RS07430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J421_RS07460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J421_RS07465	COG1595	DNA-templated transcription, initiation
J421_RS07520	COG0456	acetyltransferase
J421_RS07565	COG0322	excinuclease ABC activity
J421_RS07580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J421_RS07590	COG0318	PFAM AMP-dependent synthetase and ligase
J421_RS07600	COG1047	Peptidyl-prolyl cis-trans
J421_RS07650	COG0436	Aminotransferase
J421_RS07700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J421_RS07700	COG2169	Transcriptional regulator
J421_RS07740	COG2318	DinB family
J421_RS07750	COG1473	amidohydrolase
J421_RS07770	COG0456	acetyltransferase
J421_RS07780	COG2318	DinB family
J421_RS07805	COG1970	mechanosensitive ion channel activity
J421_RS07830	COG2770	Histidine kinase
J421_RS07830	COG3437	response regulator, receiver
J421_RS07845	COG3876	Protein conserved in bacteria
J421_RS07900	COG0745	RESPONSE REGULATOR receiver
J421_RS07910	COG0083	homoserine kinase activity
J421_RS07915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J421_RS07935	COG2199	diguanylate cyclase activity
J421_RS07950	COG0720	synthase
J421_RS07955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J421_RS07995	COG0667	Aldo Keto reductase
J421_RS08010	COG3250	beta-galactosidase activity
J421_RS08020	COG1914	H( )-stimulated, divalent metal cation uptake system
J421_RS08045	COG0488	(ABC) transporter
J421_RS08085	COG0673	inositol 2-dehydrogenase activity
J421_RS08100	COG1720	tRNA m6t6A37 methyltransferase activity
J421_RS08120	COG4095	Psort location CytoplasmicMembrane, score
J421_RS08160	COG1247	-acetyltransferase
J421_RS08165	COG2267	carboxylic ester hydrolase activity
J421_RS08210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J421_RS08215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J421_RS08220	COG2080	2 iron, 2 sulfur cluster binding
J421_RS08230	COG0628	permease
J421_RS08255	COG2205	protein histidine kinase activity
J421_RS08265	COG1960	acyl-CoA dehydrogenase activity
J421_RS08270	COG0534	Mate efflux family protein
J421_RS08295	COG0515	serine threonine protein kinase
J421_RS08295	COG2815	serine threonine protein kinase
J421_RS08300	COG0577	efflux transmembrane transporter activity
J421_RS08300	COG1136	(ABC) transporter
J421_RS08305	COG1695	Transcriptional regulator
J421_RS08310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J421_RS08335	COG4636	protein conserved in cyanobacteria
J421_RS08340	COG2382	esterase
J421_RS08350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J421_RS08360	COG0277	FAD linked oxidase domain protein
J421_RS08365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J421_RS08415	COG1672	PFAM Archaeal ATPase
J421_RS08415	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
J421_RS08470	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS08490	COG0513	Belongs to the DEAD box helicase family
J421_RS08525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J421_RS08525	COG0662	Cupin 2, conserved barrel domain protein
J421_RS08545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J421_RS08550	COG4232	protein-disulfide reductase activity
J421_RS08560	COG0488	(ABC) transporter
J421_RS08565	COG1695	Transcriptional regulator
J421_RS08570	COG0577	efflux transmembrane transporter activity
J421_RS08570	COG1136	(ABC) transporter
J421_RS08580	COG0667	Aldo Keto reductase
J421_RS08585	COG0667	Aldo Keto reductase
J421_RS08590	COG2205	protein histidine kinase activity
J421_RS08610	COG2815	serine threonine protein kinase
J421_RS08610	COG0515	serine threonine protein kinase
J421_RS08620	COG2205	protein histidine kinase activity
J421_RS08620	COG2202	Pas domain
J421_RS08650	COG2133	pyrroloquinoline quinone binding
J421_RS08665	COG4771	TonB-dependent receptor
J421_RS08675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J421_RS08675	COG2755	lipolytic protein G-D-S-L family
J421_RS08680	COG4206	TonB-dependent receptor
J421_RS08680	COG1629	transport
J421_RS08750	COG0656	L-ascorbic acid biosynthetic process
J421_RS08765	COG4221	oxidoreductase activity
J421_RS08775	COG2814	Major facilitator Superfamily
J421_RS08780	COG1881	PFAM PEBP family protein
J421_RS08785	COG1131	(ABC) transporter
J421_RS08810	COG0471	metal ion transport
J421_RS08820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J421_RS08830	COG0842	Transport permease protein
J421_RS08835	COG0842	Transport permease protein
J421_RS08840	COG1129	ABC transporter
J421_RS08840	COG0842	Transport permease protein
J421_RS08845	COG1131	(ABC) transporter
J421_RS08880	COG1136	(ABC) transporter
J421_RS08880	COG0577	efflux transmembrane transporter activity
J421_RS08910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J421_RS08915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J421_RS08935	COG2116	formate transmembrane transporter activity
J421_RS08980	COG0730	response to heat
J421_RS08990	COG3258	Cytochrome c
J421_RS09010	COG1940	carbohydrate kinase activity
J421_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
J421_RS09025	COG0170	dolichyl monophosphate biosynthetic process
J421_RS09050	COG3794	PFAM blue (type 1) copper domain protein
J421_RS09060	COG3279	Response regulator of the LytR AlgR family
J421_RS09065	COG1629	transport
J421_RS09080	COG3275	phosphorelay sensor kinase activity
J421_RS09085	COG1858	cytochrome C peroxidase
J421_RS09090	COG0515	serine threonine protein kinase
J421_RS09100	COG1506	peptidase
J421_RS09100	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS09115	COG1629	transport
J421_RS09130	COG3279	Response regulator of the LytR AlgR family
J421_RS09135	COG3275	phosphorelay sensor kinase activity
J421_RS09185	COG1858	cytochrome C peroxidase
J421_RS09200	COG2207	Transcriptional regulator
J421_RS09225	COG4952	isomerase
J421_RS09230	COG1070	Carbohydrate kinase
J421_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS09235	COG3347	Dehydrogenase
J421_RS09240	COG1556	Lactate utilization protein
J421_RS09245	COG1940	carbohydrate kinase activity
J421_RS09260	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J421_RS09270	COG0038	chloride channel
J421_RS09320	COG3193	protein, possibly involved in utilization of glycolate and propanediol
J421_RS09325	COG3386	PFAM SMP-30 Gluconolaconase
J421_RS09340	COG1252	NADH dehydrogenase
J421_RS09360	COG1595	DNA-templated transcription, initiation
J421_RS09375	COG1960	acyl-CoA dehydrogenase activity
J421_RS09385	COG0745	RESPONSE REGULATOR receiver
J421_RS09430	COG0584	glycerophosphoryl diester phosphodiesterase
J421_RS09445	COG0393	Putative heavy-metal-binding
J421_RS09450	COG0784	Response regulator, receiver
J421_RS09450	COG5002	protein histidine kinase activity
J421_RS09450	COG2198	Histidine kinase
J421_RS09455	COG2205	protein histidine kinase activity
J421_RS09455	COG2202	Pas domain
J421_RS09460	COG2271	Major facilitator Superfamily
J421_RS09465	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS09475	COG2084	Dehydrogenase
J421_RS09480	COG2721	sulfolactate sulfo-lyase activity
J421_RS09500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J421_RS09510	COG4251	negative regulation of phosphorylation
J421_RS09515	COG0784	Response regulator, receiver
J421_RS09520	COG2205	protein histidine kinase activity
J421_RS09535	COG2197	response regulator
J421_RS09540	COG2205	protein histidine kinase activity
J421_RS09545	COG2272	Belongs to the type-B carboxylesterase lipase family
J421_RS09560	COG1063	alcohol dehydrogenase
J421_RS09570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J421_RS09590	COG2132	Multicopper oxidase
J421_RS09615	COG3158	transport of potassium into the cell
J421_RS09625	COG2205	protein histidine kinase activity
J421_RS09630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J421_RS09645	COG1937	Protein conserved in bacteria
J421_RS09655	COG0659	secondary active sulfate transmembrane transporter activity
J421_RS09660	COG2267	carboxylic ester hydrolase activity
J421_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS09720	COG4771	TonB-dependent receptor
J421_RS09735	COG5002	protein histidine kinase activity
J421_RS09735	COG3850	Histidine kinase
J421_RS09770	COG0671	phosphoesterase, PA-phosphatase related
J421_RS09795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J421_RS09815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J421_RS09840	COG1136	(ABC) transporter
J421_RS09840	COG0577	efflux transmembrane transporter activity
J421_RS09920	COG2989	Protein conserved in bacteria
J421_RS09935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J421_RS09970	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS09970	COG1506	peptidase
J421_RS09980	COG2815	serine threonine protein kinase
J421_RS09980	COG0515	serine threonine protein kinase
J421_RS09985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J421_RS10000	COG0300	oxidoreductase activity
J421_RS10005	COG1902	pentaerythritol trinitrate reductase activity
J421_RS10015	COG2124	cytochrome p450
J421_RS10030	COG1566	PFAM secretion protein HlyD family protein
J421_RS10075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J421_RS10085	COG0577	efflux transmembrane transporter activity
J421_RS10085	COG1136	(ABC) transporter
J421_RS10090	COG1136	(ABC) transporter
J421_RS10090	COG0577	efflux transmembrane transporter activity
J421_RS10105	COG1649	PFAM Uncharacterised BCR, COG1649
J421_RS10115	COG1272	protein, Hemolysin III
J421_RS10150	COG1136	(ABC) transporter
J421_RS10150	COG0577	efflux transmembrane transporter activity
J421_RS10195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J421_RS10210	COG0300	oxidoreductase activity
J421_RS10225	COG1280	lysine exporter protein (LysE YggA)
J421_RS10235	COG2234	aminopeptidase activity
J421_RS10245	COG0384	phenazine biosynthesis protein PhzF
J421_RS10275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J421_RS10330	COG1668	transmembrane transport
J421_RS10335	COG4152	abc transporter atp-binding protein
J421_RS10340	COG4208	sulfate ABC transporter
J421_RS10380	COG0822	iron-sulfur transferase activity
J421_RS10385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J421_RS10390	COG2146	nitrite reductase [NAD(P)H] activity
J421_RS10395	COG0822	iron-sulfur transferase activity
J421_RS10400	COG0719	Fe-S assembly protein
J421_RS10405	COG0396	ATPase activity
J421_RS10410	COG0719	Fe-S assembly protein
J421_RS10435	COG2972	Histidine kinase
J421_RS10470	COG4942	peptidase
J421_RS10490	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS10505	COG0628	permease
J421_RS10510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J421_RS10520	COG3300	MHYT domain
J421_RS10520	COG5001	Diguanylate cyclase
J421_RS10530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS10545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS10550	COG0492	ferredoxin-NADP+ reductase activity
J421_RS10555	COG5549	protein import
J421_RS10555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS10590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J421_RS10590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J421_RS10600	COG2610	gluconate transmembrane transporter activity
J421_RS10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS10650	COG0251	oxidation-reduction process
J421_RS10655	COG0405	Gamma-glutamyltransferase
J421_RS10665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J421_RS10680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J421_RS10685	COG4266	Belongs to the allantoicase family
J421_RS10705	COG4941	Belongs to the sigma-70 factor family
J421_RS10710	COG3795	YCII-related domain
J421_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS10765	COG1672	PFAM Archaeal ATPase
J421_RS10765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
J421_RS10770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J421_RS10795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J421_RS10805	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J421_RS10835	COG4946	Tricorn protease homolog
J421_RS10835	COG0793	Belongs to the peptidase S41A family
J421_RS10915	COG0739	heme binding
J421_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS10965	COG0655	NAD(P)H dehydrogenase (quinone) activity
J421_RS10985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J421_RS11025	COG0318	PFAM AMP-dependent synthetase and ligase
J421_RS11035	COG0154	amidase activity
J421_RS11040	COG0742	ribosomal rna small subunit methyltransferase
J421_RS11050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J421_RS11075	COG4771	TonB-dependent receptor
J421_RS11095	COG4771	TonB-dependent receptor
J421_RS11100	COG0702	epimerase
J421_RS11105	COG3119	arylsulfatase activity
J421_RS11110	COG0673	inositol 2-dehydrogenase activity
J421_RS11120	COG0702	epimerase
J421_RS11165	COG2201	protein-glutamate methylesterase activity
J421_RS11185	COG2201	protein-glutamate methylesterase activity
J421_RS11220	COG4771	TonB-dependent receptor
J421_RS11225	COG0702	epimerase
J421_RS11230	COG1629	transport
J421_RS11230	COG4206	TonB-dependent receptor
J421_RS11235	COG0702	epimerase
J421_RS11255	COG3132	Protein of unknown function, DUF480
J421_RS11260	COG0640	Transcriptional regulator
J421_RS11265	COG2226	methyltransferase
J421_RS11270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J421_RS11275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J421_RS11280	COG0154	amidase activity
J421_RS11295	COG2205	protein histidine kinase activity
J421_RS11295	COG0784	Response regulator, receiver
J421_RS11310	COG1959	2 iron, 2 sulfur cluster binding
J421_RS11315	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS11320	COG0515	serine threonine protein kinase
J421_RS11320	COG2815	serine threonine protein kinase
J421_RS11340	COG1695	Transcriptional regulator
J421_RS11375	COG4221	oxidoreductase activity
J421_RS11390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J421_RS11420	COG2207	Transcriptional regulator
J421_RS11430	COG0667	Aldo Keto reductase
J421_RS11455	COG0515	serine threonine protein kinase
J421_RS11465	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J421_RS11485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J421_RS11535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J421_RS11560	COG1079	Belongs to the binding-protein-dependent transport system permease family
J421_RS11565	COG4603	Belongs to the binding-protein-dependent transport system permease family
J421_RS11570	COG3845	ABC transporter
J421_RS11575	COG1744	ABC transporter substrate-binding protein PnrA-like
J421_RS11590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J421_RS11630	COG0179	Fumarylacetoacetate (FAA) hydrolase
J421_RS11650	COG1331	Highly conserved protein containing a thioredoxin domain
J421_RS11655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J421_RS11660	COG1993	acr, cog1993
J421_RS11680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J421_RS11700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J421_RS11705	COG1597	lipid kinase activity
J421_RS11715	COG0531	amino acid
J421_RS11720	COG0069	glutamate synthase activity
J421_RS11720	COG0067	glutamate synthase
J421_RS11720	COG0070	glutamate synthase
J421_RS11760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J421_RS11790	COG0277	FAD linked oxidase domain protein
J421_RS11845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J421_RS11855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J421_RS11870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J421_RS11875	COG1595	DNA-templated transcription, initiation
J421_RS11890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J421_RS11925	COG0604	alcohol dehydrogenase
J421_RS11985	COG1832	CoA-binding protein
J421_RS11995	COG2027	D-alanyl-D-alanine carboxypeptidase
J421_RS12025	COG2010	Cytochrome c
J421_RS12025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J421_RS12030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J421_RS12050	COG0436	Aminotransferase
J421_RS12065	COG1027	Aspartate ammonia-lyase
J421_RS12070	COG4636	protein conserved in cyanobacteria
J421_RS12075	COG1446	asparaginase
J421_RS12105	COG0495	leucyl-tRNA aminoacylation
J421_RS12115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS12125	COG3158	transport of potassium into the cell
J421_RS12130	COG3158	transport of potassium into the cell
J421_RS12165	COG2814	Major facilitator Superfamily
J421_RS12170	COG1566	PFAM secretion protein HlyD family protein
J421_RS12180	COG1309	transcriptional regulator
J421_RS12190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J421_RS12205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J421_RS12210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J421_RS12210	COG1796	DNA polymerase
J421_RS12215	COG0596	Alpha beta hydrolase
J421_RS12220	COG0123	including yeast histone deacetylase and acetoin utilization protein
J421_RS12230	COG2234	aminopeptidase activity
J421_RS12240	COG1363	Peptidase, m42
J421_RS12245	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J421_RS12280	COG0714	Associated with various cellular activities
J421_RS12300	COG1960	acyl-CoA dehydrogenase activity
J421_RS12320	COG1088	dTDP-glucose 4,6-dehydratase activity
J421_RS12335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J421_RS12335	COG0646	methionine synthase
J421_RS12345	COG0646	methionine synthase
J421_RS12345	COG1410	methionine synthase
J421_RS12350	COG0762	integral membrane protein
J421_RS12390	COG4106	trans-aconitate 2-methyltransferase activity
J421_RS12425	COG1216	Glycosyl transferase, family 2
J421_RS12435	COG0297	glycogen (starch) synthase activity
J421_RS12440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J421_RS12455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J421_RS12460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J421_RS12480	COG2204	response regulator
J421_RS12485	COG0784	Response regulator, receiver
J421_RS12485	COG2205	protein histidine kinase activity
J421_RS12510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J421_RS12560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J421_RS12585	COG0354	folic acid binding
J421_RS12600	COG0247	lactate metabolic process
J421_RS12605	COG0277	FAD linked oxidase domain protein
J421_RS12610	COG0277	FAD linked oxidase domain protein
J421_RS12630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J421_RS12645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J421_RS12650	COG2096	Adenosyltransferase
J421_RS12655	COG0287	Prephenate dehydrogenase
J421_RS12655	COG1605	Chorismate mutase
J421_RS12660	COG1136	(ABC) transporter
J421_RS12660	COG0577	efflux transmembrane transporter activity
J421_RS12665	COG1695	Transcriptional regulator
J421_RS12670	COG0492	ferredoxin-NADP+ reductase activity
J421_RS12685	COG0601	transmembrane transport
J421_RS12690	COG0747	negative chemotaxis
J421_RS12715	COG3852	Histidine kinase
J421_RS12720	COG3191	aminopeptidase activity
J421_RS12730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J421_RS12735	COG0697	spore germination
J421_RS12775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J421_RS12780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J421_RS12790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J421_RS12795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J421_RS12805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J421_RS12805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J421_RS12810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J421_RS12815	COG0242	peptide deformylase activity
J421_RS12820	COG1862	Preprotein translocase
J421_RS12830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J421_RS12855	COG2255	four-way junction helicase activity
J421_RS12875	COG0632	four-way junction helicase activity
J421_RS12880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J421_RS12885	COG0217	transcriptional regulatory protein
J421_RS12890	COG0784	Response regulator, receiver
J421_RS12890	COG2205	protein histidine kinase activity
J421_RS12890	COG5002	protein histidine kinase activity
J421_RS12895	COG1132	(ABC) transporter
J421_RS12915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J421_RS12920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J421_RS12930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J421_RS12935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J421_RS12945	COG0402	S-adenosylhomocysteine deaminase activity
J421_RS12985	COG5002	protein histidine kinase activity
J421_RS12995	COG0432	Pfam Uncharacterised protein family UPF0047
J421_RS13000	COG0318	PFAM AMP-dependent synthetase and ligase
J421_RS13010	COG2094	Belongs to the DNA glycosylase MPG family
J421_RS13025	COG0156	8-amino-7-oxononanoate synthase activity
J421_RS13035	COG1063	alcohol dehydrogenase
J421_RS13050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J421_RS13055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J421_RS13080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J421_RS13085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J421_RS13090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J421_RS13130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J421_RS13135	COG1127	ABC transporter
J421_RS13145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J421_RS13150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J421_RS13155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J421_RS13165	COG4771	TonB-dependent receptor
J421_RS13175	COG1629	transport
J421_RS13200	COG0745	RESPONSE REGULATOR receiver
J421_RS13210	COG5001	Diguanylate cyclase
J421_RS13210	COG5002	protein histidine kinase activity
J421_RS13215	COG1519	Transferase
J421_RS13235	COG1704	LemA family
J421_RS13240	COG4771	TonB-dependent receptor
J421_RS13245	COG1629	transport
J421_RS13245	COG4206	TonB-dependent receptor
J421_RS13260	COG4771	TonB-dependent receptor
J421_RS13280	COG1774	PSP1 C-terminal conserved region
J421_RS13285	COG0825	malonyl-CoA metabolic process
J421_RS13305	COG0612	Peptidase, M16
J421_RS13320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J421_RS13325	COG4206	TonB-dependent receptor
J421_RS13325	COG1629	transport
J421_RS13340	COG0508	dehydrogenase complex catalyzes the overall conversion of
J421_RS13345	COG0022	dehydrogenase e1 component
J421_RS13345	COG0508	dehydrogenase complex catalyzes the overall conversion of
J421_RS13350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J421_RS13355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J421_RS13380	COG0463	Glycosyl transferase, family 2
J421_RS13410	COG0444	Belongs to the ABC transporter superfamily
J421_RS13415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J421_RS13430	COG0095	Lipoate-protein ligase
J421_RS13435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J421_RS13435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J421_RS13440	COG0509	glycine decarboxylation via glycine cleavage system
J421_RS13445	COG0237	dephospho-CoA kinase activity
J421_RS13450	COG1435	thymidine kinase activity
J421_RS13495	COG0419	ATPase involved in DNA repair
J421_RS13500	COG0456	acetyltransferase
J421_RS13515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
J421_RS13530	COG0302	gtp cyclohydrolase
J421_RS13535	COG4221	oxidoreductase activity
J421_RS13570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J421_RS13580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J421_RS13630	COG2124	cytochrome p450
J421_RS13650	COG0187	DNA topoisomerase II activity
J421_RS13665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J421_RS13670	COG1024	Enoyl-CoA hydratase
J421_RS13695	COG1131	(ABC) transporter
J421_RS13715	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J421_RS13720	COG1138	Cytochrome C-type biogenesis protein
J421_RS13735	COG1324	tolerance protein
J421_RS13750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J421_RS13765	COG1760	l-serine dehydratase
J421_RS13770	COG1760	l-serine dehydratase
J421_RS13780	COG1842	Phage shock protein A
J421_RS13795	COG0215	cysteine-tRNA ligase activity
J421_RS13830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J421_RS13845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J421_RS13850	COG0081	regulation of translation
J421_RS13855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J421_RS13860	COG0222	ribosome binding
J421_RS13865	COG0085	RNA polymerase activity
J421_RS13870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J421_RS13875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J421_RS13880	COG0049	tRNA binding
J421_RS13885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J421_RS13890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J421_RS13895	COG0051	transcription antitermination factor activity, RNA binding
J421_RS13900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J421_RS13915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J421_RS13920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J421_RS13925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J421_RS13930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J421_RS13935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J421_RS13940	COG0255	Belongs to the universal ribosomal protein uL29 family
J421_RS13945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J421_RS13950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J421_RS13955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J421_RS13965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J421_RS13970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J421_RS13975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J421_RS13980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J421_RS13985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J421_RS13990	COG1841	ribosomal large subunit assembly
J421_RS13995	COG0200	Binds to the 23S rRNA
J421_RS14000	COG0201	protein transport
J421_RS14005	COG0563	adenylate kinase activity
J421_RS14010	COG0024	Methionine aminopeptidase
J421_RS14025	COG0180	Tryptophanyl-tRNA synthetase
J421_RS14050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J421_RS14065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J421_RS14070	COG0492	ferredoxin-NADP+ reductase activity
J421_RS14080	COG0423	glycine-tRNA ligase activity
J421_RS14085	COG1164	Oligoendopeptidase f
J421_RS14095	COG0300	oxidoreductase activity
J421_RS14115	COG0123	including yeast histone deacetylase and acetoin utilization protein
J421_RS14125	COG0598	Magnesium transport protein CorA
J421_RS14135	COG2815	serine threonine protein kinase
J421_RS14135	COG0515	serine threonine protein kinase
J421_RS14140	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS14145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J421_RS14160	COG0735	belongs to the Fur family
J421_RS14175	COG0785	Cytochrome C biogenesis protein
J421_RS14180	COG0745	RESPONSE REGULATOR receiver
J421_RS14190	COG1132	(ABC) transporter
J421_RS14205	COG2815	serine threonine protein kinase
J421_RS14205	COG0515	serine threonine protein kinase
J421_RS14215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J421_RS14220	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J421_RS14240	COG0631	protein serine/threonine phosphatase activity
J421_RS14245	COG0860	N-Acetylmuramoyl-L-alanine amidase
J421_RS14280	COG2815	serine threonine protein kinase
J421_RS14280	COG0515	serine threonine protein kinase
J421_RS14285	COG0515	serine threonine protein kinase
J421_RS14285	COG2815	serine threonine protein kinase
J421_RS14330	COG2226	methyltransferase
J421_RS14335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J421_RS14345	COG2133	pyrroloquinoline quinone binding
J421_RS14350	COG0436	Aminotransferase
J421_RS14360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J421_RS14380	COG0321	lipoyl(octanoyl) transferase activity
J421_RS14380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J421_RS14385	COG0166	Belongs to the GPI family
J421_RS14400	COG2204	response regulator
J421_RS14410	COG1295	ribonuclease BN
J421_RS14435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J421_RS14440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J421_RS14455	COG1100	Small GTP-binding protein
J421_RS14460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J421_RS14465	COG1058	Belongs to the CinA family
J421_RS14465	COG1546	Belongs to the CinA family
J421_RS14470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J421_RS14480	COG0482	sulfurtransferase activity
J421_RS14485	COG1104	cysteine desulfurase activity
J421_RS14495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
J421_RS14500	COG3483	tryptophan 2,3-dioxygenase activity
J421_RS14520	COG0577	efflux transmembrane transporter activity
J421_RS14520	COG1136	(ABC) transporter
J421_RS14525	COG0577	efflux transmembrane transporter activity
J421_RS14525	COG1136	(ABC) transporter
J421_RS14535	COG1136	(ABC) transporter
J421_RS14565	COG5000	phosphorelay sensor kinase activity
J421_RS14585	COG1475	DNA binding
J421_RS14590	COG0489	protein tyrosine kinase activity
J421_RS14600	COG1606	tRNA processing
J421_RS14610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
J421_RS14620	COG2204	response regulator
J421_RS14635	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS14660	COG1666	GTP binding
J421_RS14705	COG1234	tRNA 3'-trailer cleavage
J421_RS14710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J421_RS14715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J421_RS14720	COG2890	protein-(glutamine-N5) methyltransferase activity
J421_RS14725	COG3679	Belongs to the UPF0342 family
J421_RS14730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J421_RS14735	COG0793	Belongs to the peptidase S41A family
J421_RS14745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J421_RS14750	COG1234	tRNA 3'-trailer cleavage
J421_RS14760	COG1196	nuclear chromosome segregation
J421_RS14775	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS14775	COG4946	Tricorn protease homolog
J421_RS14775	COG1506	peptidase
J421_RS14780	COG0799	negative regulation of ribosome biogenesis
J421_RS14785	COG0359	binds to the 23S rRNA
J421_RS14795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J421_RS14800	COG0360	Binds together with S18 to 16S ribosomal RNA
J421_RS14810	COG1285	pathogenesis
J421_RS14815	COG0297	glycogen (starch) synthase activity
J421_RS14820	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
J421_RS14825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS14850	COG0012	GTP binding
J421_RS14855	COG0193	aminoacyl-tRNA hydrolase activity
J421_RS14860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J421_RS14865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J421_RS14875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J421_RS14890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J421_RS14900	COG0346	lactoylglutathione lyase activity
J421_RS14905	COG3118	belongs to the thioredoxin family
J421_RS14910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J421_RS14940	COG1199	ATP-dependent helicase activity
J421_RS14945	COG2340	Cysteine-rich secretory protein family
J421_RS14950	COG0179	Fumarylacetoacetate (FAA) hydrolase
J421_RS14960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J421_RS14965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J421_RS14990	COG0138	bifunctional purine biosynthesis protein purh
J421_RS14995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J421_RS15000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J421_RS15015	COG0525	valine-tRNA ligase activity
J421_RS15030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J421_RS15055	COG1250	3-hydroxyacyl-CoA dehydrogenase
J421_RS15060	COG1960	acyl-CoA dehydrogenase activity
J421_RS15070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J421_RS15085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J421_RS15085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J421_RS15100	COG0148	phosphopyruvate hydratase activity
J421_RS15145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J421_RS15160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J421_RS15160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS15175	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS15190	COG1649	PFAM Uncharacterised BCR, COG1649
J421_RS15210	COG4946	Tricorn protease homolog
J421_RS15210	COG1506	peptidase
J421_RS15210	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS15220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J421_RS15230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J421_RS15235	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS15250	COG0037	tRNA processing
J421_RS15265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J421_RS15270	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J421_RS15295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J421_RS15300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J421_RS15305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J421_RS15315	COG0564	pseudouridine synthase activity
J421_RS15325	COG2201	protein-glutamate methylesterase activity
J421_RS15330	COG0643	Histidine kinase
J421_RS15330	COG2198	Histidine kinase
J421_RS15335	COG1776	CheC inhibitor of MCP methylation
J421_RS15350	COG1100	Small GTP-binding protein
J421_RS15355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J421_RS15375	COG2201	protein-glutamate methylesterase activity
J421_RS15400	COG0275	rRNA processing
J421_RS15415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J421_RS15420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J421_RS15425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J421_RS15430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J421_RS15435	COG0772	Belongs to the SEDS family
J421_RS15440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J421_RS15445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J421_RS15450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J421_RS15460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J421_RS15465	COG1196	nuclear chromosome segregation
J421_RS15465	COG0741	lytic transglycosylase activity
J421_RS15465	COG0739	heme binding
J421_RS15480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J421_RS15500	COG5002	protein histidine kinase activity
J421_RS15505	COG0017	Asparaginyl-tRNA synthetase
J421_RS15520	COG3956	TIGRFAM MazG family protein
J421_RS15525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J421_RS15530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J421_RS15535	COG0295	cytidine deaminase activity
J421_RS15550	COG2205	protein histidine kinase activity
J421_RS15565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J421_RS15585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J421_RS15590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J421_RS15590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J421_RS15605	COG0018	arginyl-trna synthetase
J421_RS15615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J421_RS15625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J421_RS15625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J421_RS15635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J421_RS15635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J421_RS15640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J421_RS15650	COG0438	transferase activity, transferring glycosyl groups
J421_RS15660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J421_RS15685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J421_RS15695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J421_RS15715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J421_RS15720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J421_RS15725	COG4771	TonB-dependent receptor
J421_RS15740	COG0542	response to heat
J421_RS15770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J421_RS15775	COG0540	Belongs to the ATCase OTCase family
J421_RS15780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J421_RS15790	COG0268	Binds directly to 16S ribosomal RNA
J421_RS15795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J421_RS15800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J421_RS15805	COG1187	pseudouridine synthase activity
J421_RS15810	COG0714	Associated with various cellular activities
J421_RS15825	COG2304	oxidoreductase activity
J421_RS15835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J421_RS15845	COG0438	transferase activity, transferring glycosyl groups
J421_RS15850	COG1968	undecaprenyl-diphosphatase activity
J421_RS15855	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J421_RS15855	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J421_RS15875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J421_RS15880	COG0459	protein refolding
J421_RS15910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J421_RS15915	COG0662	Cupin 2, conserved barrel domain protein
J421_RS15915	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J421_RS15920	COG0745	RESPONSE REGULATOR receiver
J421_RS15935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J421_RS15940	COG4191	Histidine kinase
J421_RS15950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J421_RS15955	COG0154	amidase activity
J421_RS15960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J421_RS15980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J421_RS15985	COG1496	oxidoreductase activity
J421_RS15990	COG0779	Required for maturation of 30S ribosomal subunits
J421_RS15995	COG2251	uridine kinase activity
J421_RS15995	COG0195	Participates in both transcription termination and antitermination
J421_RS16010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J421_RS16020	COG0196	riboflavin kinase activity
J421_RS16025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J421_RS16030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J421_RS16035	COG0084	hydrolase, TatD family'
J421_RS16050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J421_RS16060	COG0824	Thioesterase
J421_RS16075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J421_RS16075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J421_RS16080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J421_RS16085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J421_RS16120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J421_RS16125	COG2835	tetraacyldisaccharide 4'-kinase activity
J421_RS16150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J421_RS16155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J421_RS16165	COG1136	(ABC) transporter
J421_RS16175	COG3869	Catalyzes the specific phosphorylation of arginine residues in
J421_RS16180	COG0542	response to heat
J421_RS16185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J421_RS16195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J421_RS16200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J421_RS16200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J421_RS16205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J421_RS16210	COG0673	inositol 2-dehydrogenase activity
J421_RS16215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J421_RS16225	COG1663	tetraacyldisaccharide 4'-kinase activity
J421_RS16230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J421_RS16235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J421_RS16240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
J421_RS16245	COG0728	peptidoglycan biosynthetic process
J421_RS16250	COG0322	excinuclease ABC activity
J421_RS16255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J421_RS16260	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
J421_RS16270	COG1160	GTP binding
J421_RS16275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J421_RS16280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J421_RS16290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J421_RS16295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J421_RS16300	COG1254	Belongs to the acylphosphatase family
J421_RS16305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J421_RS16320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J421_RS16325	COG0463	Glycosyl transferase, family 2
J421_RS16340	COG0438	transferase activity, transferring glycosyl groups
J421_RS16345	COG0463	Glycosyl transferase, family 2
J421_RS16375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J421_RS16385	COG0504	CTP synthase activity
J421_RS16390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J421_RS16410	COG4974	Belongs to the 'phage' integrase family
J421_RS16420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J421_RS16425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
J421_RS16430	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
J421_RS16435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
J421_RS16440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J421_RS16445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J421_RS16455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J421_RS16465	COG0416	fatty acid biosynthetic process
J421_RS16470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J421_RS16480	COG0105	UTP biosynthetic process
J421_RS16485	COG0617	tRNA 3'-terminal CCA addition
J421_RS16485	COG0517	IMP dehydrogenase activity
J421_RS16485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J421_RS16490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J421_RS16495	COG0045	succinate-CoA ligase (ADP-forming) activity
J421_RS16500	COG1615	UPF0182 protein
J421_RS16505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J421_RS16510	COG1007	ATP synthesis coupled electron transport
J421_RS16525	COG0713	ATP synthesis coupled electron transport
J421_RS16530	COG0839	Belongs to the complex I subunit 6 family
J421_RS16535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J421_RS16540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J421_RS16545	COG1034	ATP synthesis coupled electron transport
J421_RS16570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J421_RS16575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J421_RS16580	COG0717	Belongs to the dCTP deaminase family
J421_RS16590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J421_RS16595	COG1053	succinate dehydrogenase
J421_RS16605	COG0039	L-malate dehydrogenase activity
J421_RS16610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J421_RS16615	COG0314	molybdopterin synthase activity
J421_RS16630	COG0505	Belongs to the CarA family
J421_RS16640	COG0149	triose-phosphate isomerase activity
J421_RS16645	COG0126	phosphoglycerate kinase activity
J421_RS16660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J421_RS16665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J421_RS16670	COG0009	L-threonylcarbamoyladenylate synthase
J421_RS16675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J421_RS16690	COG1573	uracil-dna glycosylase
J421_RS16695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J421_RS16705	COG0194	GDP metabolic process
J421_RS16710	COG1561	YicC-like family, N-terminal region
J421_RS16720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J421_RS16770	COG0402	S-adenosylhomocysteine deaminase activity
J421_RS16775	COG1228	amidohydrolase
J421_RS16785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J421_RS16795	COG1530	ribonuclease E activity
J421_RS16805	COG1960	acyl-CoA dehydrogenase activity
J421_RS16810	COG0514	ATP-dependent DNA helicase (RecQ)
J421_RS16815	COG0826	peptidase U32
J421_RS16835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J421_RS16845	COG2226	methyltransferase
J421_RS16850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J421_RS16850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J421_RS16860	COG1253	flavin adenine dinucleotide binding
J421_RS16865	COG4535	Mg2 and Co2 transporter CorC
J421_RS16870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J421_RS16875	COG1480	7TM receptor with intracellular HD hydrolase
J421_RS16880	COG1702	phosphate starvation-inducible protein PhoH
J421_RS16885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J421_RS16895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J421_RS16905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J421_RS16915	COG0159	tryptophan synthase activity
J421_RS16920	COG0133	tryptophan synthase activity
J421_RS16925	COG0135	phosphoribosylanthranilate isomerase activity
J421_RS16930	COG0134	indole-3-glycerol-phosphate synthase activity
J421_RS16935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J421_RS16940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J421_RS16950	COG0101	tRNA pseudouridine synthase activity
J421_RS16955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J421_RS16960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS16975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J421_RS16980	COG0688	phosphatidylethanolamine metabolic process
J421_RS16985	COG1183	phosphatidylcholine synthase activity
J421_RS16990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J421_RS16995	COG0047	phosphoribosylformylglycinamidine synthase activity
J421_RS17005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J421_RS17010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J421_RS17015	COG0574	Belongs to the PEP-utilizing enzyme family
J421_RS17015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J421_RS17030	COG1691	(AIR) carboxylase
J421_RS17040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J421_RS17040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J421_RS17040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J421_RS17045	COG0519	Catalyzes the synthesis of GMP from XMP
J421_RS17045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J421_RS17060	COG0442	prolyl-tRNA aminoacylation
J421_RS17065	COG0124	histidyl-tRNA synthetase
J421_RS17070	COG0285	dihydrofolate synthase activity
J421_RS17075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J421_RS17080	COG0772	Belongs to the SEDS family
J421_RS17085	COG0768	penicillin binding
J421_RS17100	COG1077	Cell shape determining protein MreB Mrl
J421_RS17105	COG0686	Belongs to the AlaDH PNT family
J421_RS17110	COG0612	Peptidase, M16
J421_RS17115	COG1185	polyribonucleotide nucleotidyltransferase activity
J421_RS17120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J421_RS17125	COG0515	serine threonine protein kinase
J421_RS17125	COG2815	serine threonine protein kinase
J421_RS17135	COG0750	zinc metalloprotease
J421_RS17140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J421_RS17145	COG0575	Belongs to the CDS family
J421_RS17155	COG0233	cytoplasmic translational termination
J421_RS17160	COG0528	UMP kinase activity
J421_RS17165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J421_RS17170	COG0052	Belongs to the universal ribosomal protein uS2 family
J421_RS17175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J421_RS17180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J421_RS17185	COG0511	ligase activity, forming carbon-carbon bonds
J421_RS17190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J421_RS17200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J421_RS17210	COG0539	negative regulation of cytoplasmic translation
J421_RS17215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J421_RS17220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J421_RS17225	COG2171	N-acyltransferase activity
J421_RS17230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J421_RS17235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J421_RS17240	COG0527	aspartate kinase activity
J421_RS17250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J421_RS17290	COG0497	DNA recombination
J421_RS17295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J421_RS17300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J421_RS17305	COG0142	geranyltranstransferase activity
J421_RS17310	COG1722	exodeoxyribonuclease VII activity
J421_RS17315	COG1570	exodeoxyribonuclease VII activity
J421_RS17320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J421_RS17325	COG1418	mRNA catabolic process
J421_RS17340	COG0072	phenylalanine-tRNA ligase activity
J421_RS17345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J421_RS17350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J421_RS17355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J421_RS17360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J421_RS17365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS17370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J421_RS17370	COG1199	ATP-dependent helicase activity
J421_RS17375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J421_RS17380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J421_RS17395	COG1366	Belongs to the anti-sigma-factor antagonist family
J421_RS17400	COG0280	phosphate acetyltransferase
J421_RS17405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J421_RS17410	COG0742	ribosomal rna small subunit methyltransferase
J421_RS17420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J421_RS17420	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J421_RS17430	COG0358	DNA primase activity
J421_RS17435	COG1193	negative regulation of DNA recombination
J421_RS17445	COG0537	adenosine 5'-monophosphoramidase activity
J421_RS17455	COG2264	protein methyltransferase activity
J421_RS17460	COG0484	heat shock protein binding
J421_RS17465	COG1420	regulation of RNA biosynthetic process
J421_RS17470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J421_RS17475	COG0758	DNA mediated transformation
J421_RS17475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J421_RS17480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J421_RS17510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J421_RS17510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J421_RS17540	COG0438	transferase activity, transferring glycosyl groups
J421_RS17555	COG0438	transferase activity, transferring glycosyl groups
J421_RS17580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J421_RS17595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J421_RS17600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J421_RS17610	COG0297	glycogen (starch) synthase activity
J421_RS17610	COG0438	transferase activity, transferring glycosyl groups
J421_RS17620	COG0438	transferase activity, transferring glycosyl groups
J421_RS17630	COG2264	protein methyltransferase activity
J421_RS17645	COG2226	methyltransferase
J421_RS17650	COG0367	asparagine synthase
J421_RS17660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J421_RS17670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J421_RS17695	COG0617	tRNA 3'-terminal CCA addition
J421_RS17705	COG0579	oxidoreductase
J421_RS17715	COG0252	asparaginase activity
J421_RS17720	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS17725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J421_RS17740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J421_RS17750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J421_RS17760	COG2137	regulation of response to DNA damage stimulus
J421_RS17765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J421_RS17770	COG0792	nuclease activity
J421_RS17775	COG0584	glycerophosphoryl diester phosphodiesterase
J421_RS17780	COG4206	TonB-dependent receptor
J421_RS17790	COG2045	Belongs to the ComB family
J421_RS17795	COG0439	Biotin carboxylase
J421_RS17800	COG0511	ligase activity, forming carbon-carbon bonds
J421_RS17805	COG0006	proline dipeptidase activity
J421_RS17810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J421_RS17820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J421_RS17825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J421_RS17845	COG1228	amidohydrolase
J421_RS17855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J421_RS17860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J421_RS17865	COG2986	histidine ammonia-lyase
J421_RS17875	COG0805	protein transport
J421_RS17885	COG2885	chlorophyll binding
J421_RS17890	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS17920	COG0629	single-stranded DNA binding
J421_RS17925	COG0456	acetyltransferase
J421_RS17930	COG1214	PFAM Peptidase M22, glycoprotease
J421_RS17935	COG0802	atpase or kinase
J421_RS17940	COG0556	nucleotide-excision repair
J421_RS17945	COG2814	Major facilitator Superfamily
J421_RS17950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J421_RS17955	COG2003	Belongs to the UPF0758 family
J421_RS17960	COG1132	(ABC) transporter
J421_RS17965	COG0653	protein targeting
J421_RS17970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J421_RS17990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J421_RS18005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J421_RS18010	COG0203	ribosomal protein L17
J421_RS18015	COG0202	RNA polymerase activity
J421_RS18025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J421_RS18030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J421_RS18035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J421_RS18040	COG0284	orotidine-5'-phosphate decarboxylase activity
J421_RS18045	COG0167	dihydroorotate dehydrogenase activity
J421_RS18055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J421_RS18070	COG1959	2 iron, 2 sulfur cluster binding
J421_RS18075	COG1027	Aspartate ammonia-lyase
J421_RS18085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS18090	COG0492	ferredoxin-NADP+ reductase activity
J421_RS18100	COG0613	PHP domain protein
J421_RS18110	COG0508	dehydrogenase complex catalyzes the overall conversion of
J421_RS18120	COG0022	dehydrogenase e1 component
J421_RS18125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J421_RS18155	COG1472	Belongs to the glycosyl hydrolase 3 family
J421_RS18160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS18170	COG0363	glucosamine-6-phosphate deaminase activity
J421_RS18175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J421_RS18180	COG2971	BadF BadG BcrA BcrD
J421_RS18190	COG1301	dicarboxylic acid transport
J421_RS18195	COG0531	amino acid
J421_RS18200	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J421_RS18230	COG5002	protein histidine kinase activity
J421_RS18235	COG0745	RESPONSE REGULATOR receiver
J421_RS18240	COG2204	response regulator
J421_RS18290	COG0437	4 iron, 4 sulfur cluster binding
J421_RS18310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J421_RS18325	COG0747	negative chemotaxis
J421_RS18330	COG0601	transmembrane transport
J421_RS18335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J421_RS18360	COG0586	Pfam SNARE associated Golgi protein
J421_RS18365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J421_RS18375	COG1166	arginine decarboxylase activity
J421_RS18390	COG1131	(ABC) transporter
J421_RS18405	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS18405	COG1506	peptidase
J421_RS18405	COG4946	Tricorn protease homolog
J421_RS18410	COG2226	methyltransferase
J421_RS18430	COG2815	serine threonine protein kinase
J421_RS18430	COG0515	serine threonine protein kinase
J421_RS18445	COG0542	response to heat
J421_RS18450	COG0596	Alpha beta hydrolase
J421_RS18515	COG4206	TonB-dependent receptor
J421_RS18520	COG3604	Transcriptional regulator
J421_RS18525	COG1629	transport
J421_RS18545	COG3253	May function as heme-dependent peroxidase
J421_RS18550	COG2608	mercury ion transmembrane transporter activity
J421_RS18605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J421_RS18645	COG1629	transport
J421_RS18660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J421_RS18670	COG2967	ApaG domain
J421_RS18675	COG1649	PFAM Uncharacterised BCR, COG1649
J421_RS18685	COG0436	Aminotransferase
J421_RS18690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J421_RS18695	COG3185	4-Hydroxyphenylpyruvate dioxygenase
J421_RS18710	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS18710	COG2030	dehydratase
J421_RS18720	COG0183	Belongs to the thiolase family
J421_RS18730	COG1250	3-hydroxyacyl-CoA dehydrogenase
J421_RS18735	COG1024	Enoyl-CoA hydratase
J421_RS18740	COG0577	efflux transmembrane transporter activity
J421_RS18740	COG1136	(ABC) transporter
J421_RS18745	COG0022	dehydrogenase e1 component
J421_RS18755	COG2151	metal-sulfur cluster biosynthetic enzyme
J421_RS18760	COG3396	Phenylacetate-CoA oxygenase
J421_RS18770	COG3396	Phenylacetate-CoA oxygenase
J421_RS18785	COG4166	transmembrane transport
J421_RS18800	COG4712	double-strand break repair protein
J421_RS18810	COG0318	PFAM AMP-dependent synthetase and ligase
J421_RS18825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J421_RS18840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J421_RS18845	COG1609	Transcriptional regulator
J421_RS18880	COG0515	serine threonine protein kinase
J421_RS18880	COG2815	serine threonine protein kinase
J421_RS18895	COG1217	gtp-binding protein TYPA
J421_RS18910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J421_RS18915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J421_RS18920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J421_RS18925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J421_RS18945	COG0481	GTPase activity
J421_RS18955	COG1940	carbohydrate kinase activity
J421_RS18980	COG0626	cystathionine gamma-synthase activity
J421_RS18985	COG2884	Cell division ATP-binding protein ftsE
J421_RS18990	COG2177	Part of the ABC transporter FtsEX involved in
J421_RS19025	COG0280	phosphate acetyltransferase
J421_RS19025	COG0281	malic enzyme
J421_RS19050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J421_RS19055	COG2202	Pas domain
J421_RS19055	COG2205	protein histidine kinase activity
J421_RS19065	COG1078	dGTPase activity
J421_RS19080	COG1132	(ABC) transporter
J421_RS19090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J421_RS19100	COG0725	ABC transporter, periplasmic molybdate-binding protein
J421_RS19105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J421_RS19110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J421_RS19115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J421_RS19120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J421_RS19125	COG2032	superoxide dismutase activity
J421_RS19160	COG0693	protein deglycase activity
J421_RS19170	COG0470	DNA polymerase III
J421_RS19175	COG0315	cyclic pyranopterin monophosphate synthase activity
J421_RS19180	COG1196	nuclear chromosome segregation
J421_RS19180	COG0739	heme binding
J421_RS19180	COG0741	lytic transglycosylase activity
J421_RS19185	COG0741	lytic transglycosylase activity
J421_RS19185	COG1388	LysM domain
J421_RS19200	COG5001	Diguanylate cyclase
J421_RS19220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J421_RS19235	COG0058	SHG alpha-glucan phosphorylase activity
J421_RS19245	COG1640	4-alpha-glucanotransferase
J421_RS19270	COG0366	Alpha amylase catalytic
J421_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS19285	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS19285	COG1506	peptidase
J421_RS19285	COG4946	Tricorn protease homolog
J421_RS19295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J421_RS19300	COG0335	large ribosomal subunit rRNA binding
J421_RS19310	COG0336	Belongs to the RNA methyltransferase TrmD family
J421_RS19315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J421_RS19320	COG0228	four-way junction DNA binding
J421_RS19325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J421_RS19330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J421_RS19335	COG2733	membrane
J421_RS19340	COG0542	response to heat
J421_RS19345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J421_RS19350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J421_RS19375	COG4085	toxin activity
J421_RS19375	COG1525	nuclease
J421_RS19375	COG0737	Belongs to the 5'-nucleotidase family
J421_RS19380	COG0572	uridine kinase
J421_RS19390	COG5002	protein histidine kinase activity
J421_RS19400	COG0248	Ppx GppA phosphatase
J421_RS19405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J421_RS19410	COG0306	phosphate transporter
J421_RS19415	COG1392	Phosphate transport regulator
J421_RS19425	COG0443	Heat shock 70 kDa protein
J421_RS19430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J421_RS19450	COG1629	transport
J421_RS19460	COG0544	peptidyl-prolyl cis-trans isomerase activity
J421_RS19465	COG0740	serine-type endopeptidase activity
J421_RS19470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J421_RS19475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J421_RS19480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J421_RS19495	COG0110	maltose O-acetyltransferase activity
J421_RS19525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J421_RS19545	COG0424	maF-like protein
J421_RS19550	COG1490	D-aminoacyl-tRNA deacylase activity
J421_RS19605	COG1595	DNA-templated transcription, initiation
J421_RS19625	COG2205	protein histidine kinase activity
J421_RS19625	COG2202	Pas domain
J421_RS19650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J421_RS19655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J421_RS19665	COG0626	cystathionine gamma-synthase activity
J421_RS19675	COG0151	Belongs to the GarS family
J421_RS19680	COG0322	excinuclease ABC activity
J421_RS19705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J421_RS19710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J421_RS19715	COG2226	methyltransferase
J421_RS19720	COG1595	DNA-templated transcription, initiation
J421_RS19740	COG1295	ribonuclease BN
J421_RS19750	COG0534	Mate efflux family protein
J421_RS19755	COG0489	protein tyrosine kinase activity
J421_RS19760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J421_RS19765	COG0531	amino acid
J421_RS19770	COG0516	GMP reductase activity
J421_RS19770	COG0517	IMP dehydrogenase activity
J421_RS19790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J421_RS19810	COG2027	D-alanyl-D-alanine carboxypeptidase
J421_RS19820	COG2264	protein methyltransferase activity
J421_RS19825	COG0247	lactate metabolic process
J421_RS19825	COG2181	nitrate reductase activity
J421_RS19830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J421_RS19835	COG2086	electron transfer activity
J421_RS19845	COG4771	TonB-dependent receptor
J421_RS19865	COG0473	3-isopropylmalate dehydrogenase activity
J421_RS19870	COG1966	Carbon starvation protein
J421_RS19875	COG2879	small protein
J421_RS19880	COG2814	Major facilitator Superfamily
J421_RS19900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J421_RS19905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J421_RS19910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J421_RS19915	COG0356	it plays a direct role in the translocation of protons across the membrane
J421_RS19935	COG0714	Associated with various cellular activities
J421_RS19945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
J421_RS19945	COG2199	diguanylate cyclase activity
J421_RS19960	COG0521	Mo-molybdopterin cofactor biosynthetic process
J421_RS19965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J421_RS19975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J421_RS19980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J421_RS19990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J421_RS20000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J421_RS20010	COG1649	PFAM Uncharacterised BCR, COG1649
J421_RS20015	COG4974	Belongs to the 'phage' integrase family
J421_RS20020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J421_RS20035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J421_RS20045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J421_RS20050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J421_RS20105	COG4191	Histidine kinase
J421_RS20110	COG4968	Prepilin-type N-terminal cleavage methylation domain
J421_RS20120	COG3852	Histidine kinase
J421_RS20125	COG1253	flavin adenine dinucleotide binding
J421_RS20175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J421_RS20185	COG0251	oxidation-reduction process
J421_RS20190	COG3616	Alanine racemase, N-terminal domain
J421_RS20195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J421_RS20225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J421_RS20260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J421_RS20285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J421_RS20315	COG0477	Major facilitator Superfamily
J421_RS20345	COG0392	lysyltransferase activity
J421_RS20365	COG2197	response regulator
J421_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS20410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J421_RS20415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS20430	COG0840	transmembrane signaling receptor activity
J421_RS20455	COG3590	peptidase
J421_RS20480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J421_RS20490	COG0515	serine threonine protein kinase
J421_RS20490	COG2815	serine threonine protein kinase
J421_RS20500	COG0515	serine threonine protein kinase
J421_RS20500	COG2815	serine threonine protein kinase
J421_RS20525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J421_RS20530	COG2010	Cytochrome c
J421_RS20540	COG4993	Dehydrogenase
J421_RS20545	COG4946	Tricorn protease homolog
J421_RS20545	COG1506	peptidase
J421_RS20545	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS20555	COG2731	YhcH YjgK YiaL family protein
J421_RS20565	COG2815	serine threonine protein kinase
J421_RS20565	COG0515	serine threonine protein kinase
J421_RS20575	COG0033	Phosphoglucomutase
J421_RS20600	COG4846	Membrane protein involved in cytochrome C biogenesis
J421_RS20630	COG2353	YceI-like domain
J421_RS20650	COG1073	alpha beta
J421_RS20665	COG0577	efflux transmembrane transporter activity
J421_RS20685	COG0515	serine threonine protein kinase
J421_RS20710	COG0366	Alpha amylase catalytic
J421_RS20730	COG0784	Response regulator, receiver
J421_RS20730	COG2205	protein histidine kinase activity
J421_RS20730	COG2198	Histidine kinase
J421_RS20745	COG0577	efflux transmembrane transporter activity
J421_RS20745	COG1136	(ABC) transporter
J421_RS20765	COG0534	Mate efflux family protein
J421_RS20780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J421_RS20785	COG3940	Belongs to the glycosyl hydrolase 43 family
J421_RS20800	COG2910	NAD(P)H-binding
J421_RS20815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J421_RS20820	COG1629	transport
J421_RS20820	COG4206	TonB-dependent receptor
J421_RS20840	COG2197	response regulator
J421_RS20845	COG0515	serine threonine protein kinase
J421_RS20845	COG2815	serine threonine protein kinase
J421_RS20885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J421_RS20890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J421_RS20920	COG2259	Doxx family
J421_RS20950	COG1459	type II secretion system
J421_RS20960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J421_RS21000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J421_RS21025	COG0531	amino acid
J421_RS21035	COG1612	heme a metabolic process
J421_RS21035	COG0109	protoheme IX farnesyltransferase activity
J421_RS21040	COG1612	heme a metabolic process
J421_RS21040	COG0109	protoheme IX farnesyltransferase activity
J421_RS21050	COG1132	(ABC) transporter
J421_RS21110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J421_RS21115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J421_RS21135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J421_RS21140	COG1131	(ABC) transporter
J421_RS21150	COG0477	Major facilitator Superfamily
J421_RS21155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J421_RS21165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J421_RS21165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J421_RS21190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J421_RS21210	COG0612	Peptidase, M16
J421_RS21265	COG1215	transferase activity, transferring glycosyl groups
J421_RS21295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J421_RS21300	COG4771	TonB-dependent receptor
J421_RS21320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J421_RS21325	COG1072	(Pantothenic acid kinase))
J421_RS21340	COG2379	hydroxypyruvate reductase
J421_RS21380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J421_RS21405	COG0861	Integral membrane protein TerC family
J421_RS21415	COG0602	queuosine metabolic process
J421_RS21420	COG0791	NLP P60 protein
J421_RS21455	COG0513	Belongs to the DEAD box helicase family
J421_RS21465	COG4772	TonB-dependent receptor
J421_RS21500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J421_RS21530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J421_RS21535	COG0113	porphobilinogen synthase activity
J421_RS21545	COG0181	hydroxymethylbilane synthase activity
J421_RS21550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J421_RS21555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J421_RS21560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J421_RS21620	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS21630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J421_RS21665	COG2072	flavoprotein involved in K transport
J421_RS21670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J421_RS21675	COG2706	6-phosphogluconolactonase activity
J421_RS21680	COG3386	PFAM SMP-30 Gluconolaconase
J421_RS21685	COG0673	inositol 2-dehydrogenase activity
J421_RS21695	COG3734	2-keto-3-deoxy-galactonokinase
J421_RS21700	COG0800	Aldolase
J421_RS21705	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS21755	COG1002	Type II restriction enzyme, methylase subunits
J421_RS21760	COG1061	Type III restriction enzyme res subunit
J421_RS21765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J421_RS21825	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS21835	COG1234	tRNA 3'-trailer cleavage
J421_RS21850	COG1607	acyl-coa hydrolase
J421_RS21880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J421_RS21900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J421_RS21905	COG1309	transcriptional regulator
J421_RS21915	COG2239	Acts as a magnesium transporter
J421_RS21940	COG0531	amino acid
J421_RS21965	COG1136	(ABC) transporter
J421_RS21985	COG0456	acetyltransferase
J421_RS21985	COG1846	Transcriptional regulator
J421_RS22020	COG0494	nUDIX hydrolase
J421_RS22030	COG1619	proteins homologs of microcin C7 resistance protein MccF
J421_RS22040	COG1215	transferase activity, transferring glycosyl groups
J421_RS22080	COG0670	Belongs to the BI1 family
J421_RS22085	COG2154	pterin-4-alpha-carbinolamine dehydratase
J421_RS22100	COG0714	Associated with various cellular activities
J421_RS22140	COG1376	ErfK ybiS ycfS ynhG family protein
J421_RS22150	COG1643	Atp-dependent helicase
J421_RS22170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS22195	COG1459	type II secretion system
J421_RS22255	COG0135	phosphoribosylanthranilate isomerase activity
J421_RS22260	COG2261	transglycosylase associated protein
J421_RS22265	COG1250	3-hydroxyacyl-CoA dehydrogenase
J421_RS22265	COG1024	Enoyl-CoA hydratase
J421_RS22270	COG0183	Belongs to the thiolase family
J421_RS22280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J421_RS22285	COG1595	DNA-templated transcription, initiation
J421_RS22320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J421_RS22335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J421_RS22340	COG1643	Atp-dependent helicase
J421_RS22350	COG0205	6-phosphofructokinase activity
J421_RS22375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J421_RS22385	COG0513	Belongs to the DEAD box helicase family
J421_RS22390	COG2267	carboxylic ester hydrolase activity
J421_RS22400	COG1073	alpha beta
J421_RS22410	COG2815	serine threonine protein kinase
J421_RS22410	COG0515	serine threonine protein kinase
J421_RS22420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J421_RS22470	COG3940	Belongs to the glycosyl hydrolase 43 family
J421_RS22475	COG0702	epimerase
J421_RS22480	COG4771	TonB-dependent receptor
J421_RS22485	COG1609	Transcriptional regulator
J421_RS22490	COG1085	galactose-1-phosphate uridylyltransferase
J421_RS22495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J421_RS22505	COG0537	adenosine 5'-monophosphoramidase activity
J421_RS22520	COG0022	dehydrogenase e1 component
J421_RS22555	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J421_RS22570	COG0501	Belongs to the peptidase M48B family
J421_RS22575	COG3411	Ferredoxin
J421_RS22585	COG2897	thiosulfate sulfurtransferase activity
J421_RS22595	COG0254	rRNA binding
J421_RS22610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J421_RS22615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J421_RS22620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J421_RS22650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J421_RS22660	COG1515	deoxyribonuclease V activity
J421_RS22670	COG0667	Aldo Keto reductase
J421_RS22675	COG2205	protein histidine kinase activity
J421_RS22675	COG2202	Pas domain
J421_RS22690	COG3661	Belongs to the glycosyl hydrolase 67 family
J421_RS22710	COG3693	PFAM glycoside hydrolase, family 10
J421_RS22710	COG3507	Belongs to the glycosyl hydrolase 43 family
J421_RS22710	COG2382	esterase
J421_RS22720	COG2211	Major facilitator Superfamily
J421_RS22725	COG1472	Belongs to the glycosyl hydrolase 3 family
J421_RS22745	COG3507	Belongs to the glycosyl hydrolase 43 family
J421_RS22760	COG3250	beta-galactosidase activity
J421_RS22770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J421_RS22775	COG1629	transport
J421_RS22780	COG1609	Transcriptional regulator
J421_RS22795	COG0673	inositol 2-dehydrogenase activity
J421_RS22805	COG0006	proline dipeptidase activity
J421_RS22810	COG3345	alpha-galactosidase
J421_RS22815	COG1162	GTPase activity
J421_RS22825	COG0506	proline dehydrogenase activity
J421_RS22870	COG1250	3-hydroxyacyl-CoA dehydrogenase
J421_RS22870	COG1024	Enoyl-CoA hydratase
J421_RS22875	COG0183	Belongs to the thiolase family
J421_RS22880	COG0697	spore germination
J421_RS22890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J421_RS23195	COG3728	DNA packaging
J421_RS23195	COG5484	DNA packaging
J421_RS23515	COG3728	DNA packaging
J421_RS23515	COG5484	DNA packaging
J421_RS23565	COG0583	DNA-binding transcription factor activity
J421_RS23570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J421_RS23585	COG2423	ornithine cyclodeaminase activity
J421_RS23590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J421_RS23595	COG0577	efflux transmembrane transporter activity
J421_RS23635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS23650	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS23665	COG3850	Histidine kinase
J421_RS23665	COG3437	response regulator, receiver
J421_RS23665	COG2205	protein histidine kinase activity
J421_RS23665	COG4999	Histidine kinase
J421_RS23715	COG0577	efflux transmembrane transporter activity
J421_RS23715	COG1136	(ABC) transporter
J421_RS23735	COG0577	efflux transmembrane transporter activity
J421_RS23755	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J421_RS23765	COG3250	beta-galactosidase activity
J421_RS23775	COG0543	2 iron, 2 sulfur cluster binding
J421_RS23775	COG0633	Ferredoxin
J421_RS23780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J421_RS23800	COG0577	efflux transmembrane transporter activity
J421_RS23800	COG1136	(ABC) transporter
J421_RS23840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J421_RS23845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J421_RS23860	COG4206	TonB-dependent receptor
J421_RS23860	COG1629	transport
J421_RS23880	COG2814	Major facilitator Superfamily
J421_RS23885	COG0583	DNA-binding transcription factor activity
J421_RS23895	COG0596	Alpha beta hydrolase
J421_RS23920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS23930	COG0412	Dienelactone hydrolase
J421_RS23970	COG0456	acetyltransferase
J421_RS23975	COG1082	Xylose isomerase domain protein TIM barrel
J421_RS23980	COG0515	serine threonine protein kinase
J421_RS23990	COG1126	abc transporter atp-binding protein
J421_RS23995	COG0765	amino acid transport
J421_RS24005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J421_RS24025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J421_RS24030	COG1132	(ABC) transporter
J421_RS24055	COG0673	inositol 2-dehydrogenase activity
J421_RS24060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J421_RS24065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J421_RS24100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J421_RS24105	COG0129	dihydroxy-acid dehydratase activity
J421_RS24115	COG0440	acetolactate synthase activity
J421_RS24120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J421_RS24150	COG0473	3-isopropylmalate dehydrogenase activity
J421_RS24155	COG0066	3-isopropylmalate dehydratase activity
J421_RS24160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J421_RS24165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J421_RS24175	COG3842	ATPase activity
J421_RS24190	COG1136	(ABC) transporter
J421_RS24190	COG0577	efflux transmembrane transporter activity
J421_RS24195	COG1695	Transcriptional regulator
J421_RS24225	COG1162	GTPase activity
J421_RS24245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J421_RS24270	COG1408	metallophosphoesterase
J421_RS24280	COG1174	glycine betaine transport
J421_RS24330	COG2205	protein histidine kinase activity
J421_RS24340	COG2815	serine threonine protein kinase
J421_RS24340	COG0515	serine threonine protein kinase
J421_RS24355	COG4771	TonB-dependent receptor
J421_RS24365	COG1802	Transcriptional regulator
J421_RS24380	COG4771	TonB-dependent receptor
J421_RS24385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J421_RS24400	COG1501	Belongs to the glycosyl hydrolase 31 family
J421_RS24415	COG1501	Belongs to the glycosyl hydrolase 31 family
J421_RS24450	COG3664	PFAM glycoside hydrolase family 39
J421_RS24465	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS24470	COG2271	Major facilitator Superfamily
J421_RS24485	COG0006	proline dipeptidase activity
J421_RS24490	COG1802	Transcriptional regulator
J421_RS24495	COG1012	belongs to the aldehyde dehydrogenase family
J421_RS24500	COG3938	Belongs to the proline racemase family
J421_RS24520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J421_RS24535	COG1069	ribulokinase activity
J421_RS24550	COG0515	serine threonine protein kinase
J421_RS24550	COG2815	serine threonine protein kinase
J421_RS24560	COG0006	proline dipeptidase activity
J421_RS24585	COG0577	efflux transmembrane transporter activity
J421_RS24585	COG1136	(ABC) transporter
J421_RS24600	COG0577	efflux transmembrane transporter activity
J421_RS24600	COG1136	(ABC) transporter
J421_RS24605	COG0577	efflux transmembrane transporter activity
J421_RS24605	COG1136	(ABC) transporter
J421_RS24630	COG3275	phosphorelay sensor kinase activity
J421_RS24640	COG3279	Response regulator of the LytR AlgR family
J421_RS24670	COG1228	amidohydrolase
J421_RS24680	COG2205	protein histidine kinase activity
J421_RS24695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS24705	COG2353	YceI-like domain
J421_RS24750	COG1054	Belongs to the UPF0176 family
J421_RS24780	COG0745	RESPONSE REGULATOR receiver
J421_RS24785	COG2972	Histidine kinase
J421_RS24785	COG2205	protein histidine kinase activity
J421_RS24840	COG1131	(ABC) transporter
J421_RS24860	COG0626	cystathionine gamma-synthase activity
J421_RS24865	COG0460	homoserine dehydrogenase
J421_RS24865	COG0527	aspartate kinase activity
J421_RS24895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J421_RS24935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J421_RS24940	COG0840	transmembrane signaling receptor activity
J421_RS24955	COG0515	serine threonine protein kinase
J421_RS24955	COG2815	serine threonine protein kinase
J421_RS24970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J421_RS24995	COG2197	response regulator
J421_RS25010	COG1053	succinate dehydrogenase
J421_RS25015	COG2311	Membrane
J421_RS25075	COG4974	Belongs to the 'phage' integrase family
J421_RS25115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J421_RS25120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J421_RS25135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J421_RS25180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J421_RS25180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J421_RS25185	COG2190	(PTS) system
J421_RS25185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J421_RS25185	COG1263	PTS System
J421_RS25225	COG2226	methyltransferase
J421_RS25240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
J421_RS25245	COG1131	(ABC) transporter
J421_RS25265	COG4263	nitrous-oxide reductase activity
J421_RS25270	COG1959	2 iron, 2 sulfur cluster binding
J421_RS25290	COG2197	response regulator
J421_RS25295	COG4585	Histidine kinase
J421_RS25365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J421_RS25365	COG0574	Belongs to the PEP-utilizing enzyme family
J421_RS25370	COG2989	Protein conserved in bacteria
J421_RS25385	COG0784	Response regulator, receiver
J421_RS25395	COG1376	ErfK ybiS ycfS ynhG family protein
J421_RS25425	COG1136	(ABC) transporter
J421_RS25425	COG0577	efflux transmembrane transporter activity
J421_RS25445	COG0071	Belongs to the small heat shock protein (HSP20) family
J421_RS25470	COG0577	efflux transmembrane transporter activity
J421_RS25470	COG1136	(ABC) transporter
J421_RS25480	COG4657	Part of a membrane complex involved in electron transport
J421_RS25485	COG4660	Part of a membrane complex involved in electron transport
J421_RS25495	COG4659	FMN binding
J421_RS25500	COG4658	electron transport chain
J421_RS25505	COG4656	Part of a membrane complex involved in electron transport
J421_RS25510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J421_RS25510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J421_RS25510	COG0674	pyruvate-flavodoxin oxidoreductase activity
J421_RS25510	COG1013	pyruvate-flavodoxin oxidoreductase activity
J421_RS25515	COG1245	4Fe-4S binding domain
J421_RS25515	COG2878	Part of a membrane complex involved in electron transport
J421_RS25525	COG1013	pyruvate-flavodoxin oxidoreductase activity
J421_RS25530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J421_RS25530	COG0674	pyruvate-flavodoxin oxidoreductase activity
J421_RS25540	COG0517	IMP dehydrogenase activity
J421_RS25555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J421_RS25565	COG1131	(ABC) transporter
J421_RS25595	COG2205	protein histidine kinase activity
J421_RS25665	COG3685	Protein conserved in bacteria
J421_RS25680	COG2160	L-arabinose isomerase activity
J421_RS25695	COG3275	phosphorelay sensor kinase activity
J421_RS25725	COG4968	Prepilin-type N-terminal cleavage methylation domain
J421_RS25735	COG1846	Transcriptional regulator
J421_RS25760	COG3661	Belongs to the glycosyl hydrolase 67 family
J421_RS25790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS25795	COG1136	(ABC) transporter
J421_RS25795	COG0577	efflux transmembrane transporter activity
J421_RS25810	COG1595	DNA-templated transcription, initiation
J421_RS25815	COG3794	PFAM blue (type 1) copper domain protein
J421_RS25825	COG0515	serine threonine protein kinase
J421_RS25955	COG1139	Iron-sulfur cluster binding protein
J421_RS25975	COG1129	ABC transporter
J421_RS25980	COG1472	Belongs to the glycosyl hydrolase 3 family
J421_RS25990	COG1309	transcriptional regulator
J421_RS26015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J421_RS26020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS26025	COG2610	gluconate transmembrane transporter activity
J421_RS26085	COG3279	Response regulator of the LytR AlgR family
J421_RS26115	COG0577	efflux transmembrane transporter activity
J421_RS26115	COG1136	(ABC) transporter
J421_RS26140	COG1136	(ABC) transporter
J421_RS26140	COG0577	efflux transmembrane transporter activity
J421_RS26160	COG0714	Associated with various cellular activities
J421_RS26190	COG2815	serine threonine protein kinase
J421_RS26190	COG0515	serine threonine protein kinase
J421_RS26195	COG4095	Psort location CytoplasmicMembrane, score
J421_RS26205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J421_RS26210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
J421_RS26225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS26250	COG1278	Cold shock
J421_RS26255	COG1764	response to oxidative stress
J421_RS26260	COG1136	(ABC) transporter
J421_RS26260	COG0577	efflux transmembrane transporter activity
J421_RS26270	COG1418	mRNA catabolic process
J421_RS26280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J421_RS26330	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS26330	COG1506	peptidase
J421_RS26375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J421_RS26405	COG0456	acetyltransferase
J421_RS26495	COG2860	membrane
J421_RS26510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J421_RS26600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J421_RS26780	COG1671	Belongs to the UPF0178 family
J421_RS26990	COG2226	methyltransferase
J421_RS27005	COG1136	(ABC) transporter
J421_RS27005	COG0577	efflux transmembrane transporter activity
J421_RS27075	COG5002	protein histidine kinase activity
J421_RS27100	COG1132	(ABC) transporter
J421_RS27120	COG0640	Transcriptional regulator
J421_RS27155	COG1595	DNA-templated transcription, initiation
J421_RS27170	COG3275	phosphorelay sensor kinase activity
J421_RS27175	COG3279	Response regulator of the LytR AlgR family
J421_RS27180	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
J421_RS27195	COG2070	2-Nitropropane dioxygenase
J421_RS27215	COG3590	peptidase
J421_RS27230	COG5002	protein histidine kinase activity
J421_RS27240	COG1136	(ABC) transporter
J421_RS27240	COG0577	efflux transmembrane transporter activity
J421_RS27255	COG1410	methionine synthase
J421_RS27255	COG0646	methionine synthase
J421_RS27275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J421_RS27280	COG1312	Catalyzes the dehydration of D-mannonate
J421_RS27285	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS27295	COG3250	beta-galactosidase activity
J421_RS27310	COG4771	TonB-dependent receptor
J421_RS27315	COG2186	Transcriptional regulator
J421_RS27325	COG2197	response regulator
J421_RS27335	COG0288	reversible hydration of carbon dioxide
J421_RS27450	COG1566	PFAM secretion protein HlyD family protein
J421_RS27470	COG0596	Alpha beta hydrolase
J421_RS27475	COG1794	racemase activity, acting on amino acids and derivatives
J421_RS27490	COG1131	(ABC) transporter
J421_RS27495	COG1131	(ABC) transporter
J421_RS27500	COG0842	Transport permease protein
J421_RS27505	COG0842	Transport permease protein
J421_RS27530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J421_RS27540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J421_RS27545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS27650	COG0667	Aldo Keto reductase
J421_RS27665	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS27670	COG1690	Belongs to the RtcB family
J421_RS27680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J421_RS27720	COG0667	Aldo Keto reductase
J421_RS27730	COG0577	efflux transmembrane transporter activity
J421_RS27730	COG1136	(ABC) transporter
J421_RS27810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J421_RS27835	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J421_RS27855	COG1136	(ABC) transporter
J421_RS27855	COG0577	efflux transmembrane transporter activity
J421_RS27860	COG1136	(ABC) transporter
J421_RS27860	COG0577	efflux transmembrane transporter activity
J421_RS27865	COG1090	epimerase
J421_RS27870	COG0740	serine-type endopeptidase activity
J421_RS27890	COG0577	efflux transmembrane transporter activity
J421_RS27890	COG1136	(ABC) transporter
J421_RS27900	COG0577	efflux transmembrane transporter activity
J421_RS27900	COG1136	(ABC) transporter
J421_RS27920	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS27970	COG1024	Enoyl-CoA hydratase
J421_RS27975	COG1960	acyl-CoA dehydrogenase activity
J421_RS28010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J421_RS28015	COG0746	molybdenum cofactor guanylyltransferase activity
J421_RS28030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J421_RS28045	COG0673	inositol 2-dehydrogenase activity
J421_RS28060	COG1609	Transcriptional regulator
J421_RS28070	COG4771	TonB-dependent receptor
J421_RS28080	COG1172	Belongs to the binding-protein-dependent transport system permease family
J421_RS28090	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS28095	COG0179	Fumarylacetoacetate (FAA) hydrolase
J421_RS28110	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS28120	COG1063	alcohol dehydrogenase
J421_RS28125	COG1879	ABC-type sugar transport system periplasmic component
J421_RS28130	COG1129	ABC transporter
J421_RS28145	COG1629	transport
J421_RS28165	COG1904	glucuronate isomerase
J421_RS28190	COG2205	protein histidine kinase activity
J421_RS28200	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS28285	COG1082	Xylose isomerase domain protein TIM barrel
J421_RS28290	COG1312	Catalyzes the dehydration of D-mannonate
J421_RS28295	COG0673	inositol 2-dehydrogenase activity
J421_RS28300	COG0673	inositol 2-dehydrogenase activity
J421_RS28310	COG2390	Transcriptional regulator
J421_RS28315	COG3250	beta-galactosidase activity
J421_RS28320	COG0577	efflux transmembrane transporter activity
J421_RS28320	COG1136	(ABC) transporter
J421_RS28335	COG3345	alpha-galactosidase
J421_RS28345	COG0673	inositol 2-dehydrogenase activity
J421_RS28355	COG2197	response regulator
J421_RS28385	COG1404	Belongs to the peptidase S8 family
J421_RS28420	COG0302	gtp cyclohydrolase
J421_RS28430	COG5002	protein histidine kinase activity
J421_RS28430	COG2198	Histidine kinase
J421_RS28430	COG0784	Response regulator, receiver
J421_RS28455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J421_RS28460	COG3189	MarR family transcriptional regulator
J421_RS28465	COG2197	response regulator
J421_RS28470	COG2205	protein histidine kinase activity
J421_RS28500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J421_RS28505	COG0489	protein tyrosine kinase activity
J421_RS28515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS28525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J421_RS28535	COG3850	Histidine kinase
J421_RS28540	COG1301	dicarboxylic acid transport
J421_RS28565	COG5002	protein histidine kinase activity
J421_RS28570	COG2207	Transcriptional regulator
J421_RS28575	COG2197	response regulator
J421_RS28580	COG0657	acetylesterase activity
J421_RS28610	COG0488	(ABC) transporter
J421_RS28615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J421_RS28680	COG3347	Dehydrogenase
J421_RS28680	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS28685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J421_RS28690	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
J421_RS28720	COG0640	Transcriptional regulator
J421_RS28750	COG0604	alcohol dehydrogenase
J421_RS28750	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS28750	COG3321	synthase
J421_RS28755	COG2207	Transcriptional regulator
J421_RS28785	COG5002	protein histidine kinase activity
J421_RS28785	COG2205	protein histidine kinase activity
J421_RS28785	COG0784	Response regulator, receiver
J421_RS28790	COG1228	amidohydrolase
J421_RS28830	COG0604	alcohol dehydrogenase
J421_RS28845	COG1131	(ABC) transporter
J421_RS28865	COG3279	Response regulator of the LytR AlgR family
J421_RS28870	COG3275	phosphorelay sensor kinase activity
J421_RS28880	COG0515	serine threonine protein kinase
J421_RS28880	COG2815	serine threonine protein kinase
J421_RS28885	COG1063	alcohol dehydrogenase
J421_RS28895	COG2972	Histidine kinase
J421_RS28900	COG3279	Response regulator of the LytR AlgR family
J421_RS28965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J421_RS28975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J421_RS29000	COG0277	FAD linked oxidase domain protein
J421_RS29035	COG5002	protein histidine kinase activity
J421_RS29040	COG0745	RESPONSE REGULATOR receiver
J421_RS29045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS29085	COG1404	Belongs to the peptidase S8 family
J421_RS29140	COG0577	efflux transmembrane transporter activity
J421_RS29150	COG2207	Transcriptional regulator
J421_RS29180	COG0577	efflux transmembrane transporter activity
J421_RS29180	COG1136	(ABC) transporter
J421_RS29195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
J421_RS29225	COG4447	cellulose binding
J421_RS29240	COG0515	serine threonine protein kinase
J421_RS29240	COG2815	serine threonine protein kinase
J421_RS29260	COG1629	transport
J421_RS29340	COG1136	(ABC) transporter
J421_RS29340	COG0577	efflux transmembrane transporter activity
J421_RS29350	COG4124	Belongs to the glycosyl hydrolase 26 family
J421_RS29350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J421_RS29385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS29400	COG1028	Short-chain dehydrogenase reductase Sdr
J421_RS29400	COG3321	synthase
J421_RS29400	COG0604	alcohol dehydrogenase
J421_RS29405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS29410	COG1595	DNA-templated transcription, initiation
J421_RS29440	COG0577	efflux transmembrane transporter activity
J421_RS29440	COG1136	(ABC) transporter
J421_RS29445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J421_RS29460	COG1472	Belongs to the glycosyl hydrolase 3 family
J421_RS29485	COG0784	Response regulator, receiver
J421_RS29485	COG2205	protein histidine kinase activity
J421_RS29485	COG5002	protein histidine kinase activity
J421_RS29500	COG3655	Transcriptional regulator
J421_RS29515	COG1136	(ABC) transporter
J421_RS29515	COG0577	efflux transmembrane transporter activity
J421_RS29540	COG0577	efflux transmembrane transporter activity
J421_RS29540	COG1136	(ABC) transporter
J421_RS29545	COG1136	(ABC) transporter
J421_RS29545	COG0577	efflux transmembrane transporter activity
J421_RS29595	COG1252	NADH dehydrogenase
J421_RS29605	COG2205	protein histidine kinase activity
J421_RS29615	COG2204	response regulator
J421_RS29620	COG2201	protein-glutamate methylesterase activity
J421_RS29625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J421_RS29635	COG0840	transmembrane signaling receptor activity
J421_RS29640	COG0835	chemotaxis
J421_RS29650	COG0745	RESPONSE REGULATOR receiver
J421_RS29675	COG2909	trisaccharide binding
J421_RS29680	COG2814	Major facilitator Superfamily
J421_RS29695	COG2072	flavoprotein involved in K transport
J421_RS29710	COG1858	cytochrome C peroxidase
J421_RS29735	COG1695	Transcriptional regulator
J421_RS29770	COG0709	Synthesizes selenophosphate from selenide and ATP
J421_RS29790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J421_RS29795	COG4946	Tricorn protease homolog
J421_RS29795	COG1506	peptidase
J421_RS29795	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS29820	COG0784	Response regulator, receiver
J421_RS29820	COG2198	Histidine kinase
J421_RS29820	COG2205	protein histidine kinase activity
J421_RS29835	COG0363	glucosamine-6-phosphate deaminase activity
J421_RS29865	COG1136	(ABC) transporter
J421_RS29865	COG0577	efflux transmembrane transporter activity
J421_RS29875	COG1473	amidohydrolase
J421_RS29875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J421_RS29880	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS29890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J421_RS29900	COG1322	Protein conserved in bacteria
J421_RS29925	COG0626	cystathionine gamma-synthase activity
J421_RS29950	COG1940	carbohydrate kinase activity
J421_RS29965	COG2205	protein histidine kinase activity
J421_RS30000	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J421_RS30010	COG1136	(ABC) transporter
J421_RS30010	COG0577	efflux transmembrane transporter activity
J421_RS30020	COG1136	(ABC) transporter
J421_RS30045	COG1376	ErfK ybiS ycfS ynhG family protein
J421_RS30055	COG3118	belongs to the thioredoxin family
J421_RS30085	COG3279	Response regulator of the LytR AlgR family
J421_RS30090	COG3275	phosphorelay sensor kinase activity
J421_RS30150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J421_RS30160	COG0531	amino acid
J421_RS30165	COG3250	beta-galactosidase activity
J421_RS30190	COG0730	response to heat
J421_RS30205	COG5654	RES domain protein
J421_RS30215	COG4946	Tricorn protease homolog
J421_RS30215	COG0793	Belongs to the peptidase S41A family
J421_RS30220	COG0517	IMP dehydrogenase activity
J421_RS30220	COG0617	tRNA 3'-terminal CCA addition
J421_RS30220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J421_RS30225	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS30265	COG0076	glutamate decarboxylase activity
J421_RS30280	COG2192	nodulation
J421_RS30295	COG0529	Catalyzes the synthesis of activated sulfate
J421_RS30300	COG0175	sulfate reduction
J421_RS30305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J421_RS30305	COG2755	lipolytic protein G-D-S-L family
J421_RS30325	COG0463	Glycosyl transferase, family 2
J421_RS30350	COG2091	lysine biosynthetic process via aminoadipic acid
J421_RS30435	COG3591	Belongs to the peptidase S1B family
J421_RS30445	COG4771	TonB-dependent receptor
J421_RS30460	COG4948	Mandelate Racemase Muconate Lactonizing
J421_RS30470	COG1629	transport
J421_RS30480	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS30515	COG0793	Belongs to the peptidase S41A family
J421_RS30515	COG4946	Tricorn protease homolog
J421_RS30535	COG0531	amino acid
J421_RS30575	COG0739	heme binding
J421_RS30590	COG3275	phosphorelay sensor kinase activity
J421_RS30595	COG3279	Response regulator of the LytR AlgR family
J421_RS30600	COG0252	asparaginase activity
J421_RS30650	COG4771	TonB-dependent receptor
J421_RS30675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J421_RS30685	COG0277	FAD linked oxidase domain protein
J421_RS30700	COG1960	acyl-CoA dehydrogenase activity
J421_RS30715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J421_RS30730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J421_RS30750	COG0577	efflux transmembrane transporter activity
J421_RS30750	COG1136	(ABC) transporter
J421_RS30785	COG0459	protein refolding
J421_RS30790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J421_RS30805	COG3459	Glycosyltransferase 36 associated
J421_RS30815	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J421_RS30830	COG5002	protein histidine kinase activity
J421_RS30830	COG2205	protein histidine kinase activity
J421_RS30830	COG0784	Response regulator, receiver
J421_RS30845	COG0515	serine threonine protein kinase
J421_RS30845	COG2815	serine threonine protein kinase
J421_RS30860	COG2205	protein histidine kinase activity
J421_RS30860	COG2202	Pas domain
J421_RS30875	COG0628	permease
J421_RS30935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J421_RS30940	COG1278	Cold shock
J421_RS30950	COG1819	glycosyl
J421_RS30960	COG1309	transcriptional regulator
J421_RS30980	COG3458	cephalosporin-C deacetylase activity
J421_RS30985	COG0577	efflux transmembrane transporter activity
J421_RS30985	COG1136	(ABC) transporter
J421_RS30990	COG1695	Transcriptional regulator
J421_RS31030	COG1620	l-lactate permease
J421_RS31040	COG0577	efflux transmembrane transporter activity
J421_RS31040	COG1136	(ABC) transporter
J421_RS31055	COG1063	alcohol dehydrogenase
J421_RS31065	COG1136	(ABC) transporter
J421_RS31065	COG0577	efflux transmembrane transporter activity
J421_RS31070	COG2267	carboxylic ester hydrolase activity
J421_RS31085	COG0386	Belongs to the glutathione peroxidase family
J421_RS31090	COG2234	aminopeptidase activity
J421_RS31095	COG3275	phosphorelay sensor kinase activity
J421_RS31130	COG3275	phosphorelay sensor kinase activity
J421_RS31150	COG3275	phosphorelay sensor kinase activity
J421_RS31180	COG0577	efflux transmembrane transporter activity
J421_RS31180	COG1136	(ABC) transporter
J421_RS31190	COG2373	Large extracellular alpha-helical protein
J421_RS31225	COG1609	Transcriptional regulator
J421_RS31230	COG1629	transport
J421_RS31230	COG4206	TonB-dependent receptor
J421_RS31235	COG0702	epimerase
J421_RS31250	COG1629	transport
J421_RS31260	COG1629	transport
J421_RS31260	COG4206	TonB-dependent receptor
J421_RS31265	COG0702	epimerase
J421_RS31315	COG2815	serine threonine protein kinase
J421_RS31315	COG0515	serine threonine protein kinase
J421_RS31335	COG3842	ATPase activity
J421_RS31340	COG0395	ABC-type sugar transport system, permease component
J421_RS31345	COG1175	transmembrane transport
J421_RS31355	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
J421_RS31400	COG1595	DNA-templated transcription, initiation
J421_RS31415	COG0784	Response regulator, receiver
J421_RS31415	COG2205	protein histidine kinase activity
J421_RS31420	COG3447	MASE1 domain protein
J421_RS31420	COG5001	Diguanylate cyclase
J421_RS31420	COG5002	protein histidine kinase activity
J421_RS31435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J421_RS31445	COG4946	Tricorn protease homolog
J421_RS31445	COG1506	peptidase
J421_RS31445	COG0823	Involved in the tonB-independent uptake of proteins
J421_RS31465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
J421_RS31470	COG2366	antibiotic biosynthetic process
J421_RS31490	COG0004	ammonium transporteR
J421_RS31495	COG0347	Belongs to the P(II) protein family
J421_RS31500	COG4771	TonB-dependent receptor
J421_RS31505	COG4206	TonB-dependent receptor
J421_RS31505	COG1629	transport
J421_RS31510	COG0702	epimerase
J421_RS31515	COG1629	transport
J421_RS31520	COG2814	Major facilitator Superfamily
J421_RS31535	COG2202	Pas domain
J421_RS31535	COG2205	protein histidine kinase activity
J421_RS31555	COG4447	cellulose binding
J421_RS31565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J421_RS31580	COG0515	serine threonine protein kinase
J421_RS31580	COG2815	serine threonine protein kinase
J421_RS31595	COG0723	plastoquinol--plastocyanin reductase activity
J421_RS31605	COG0577	efflux transmembrane transporter activity
J421_RS31605	COG1136	(ABC) transporter
J421_RS31620	COG0577	efflux transmembrane transporter activity
J421_RS31655	COG0793	Belongs to the peptidase S41A family
J421_RS31665	COG2815	serine threonine protein kinase
J421_RS31665	COG0515	serine threonine protein kinase
J421_RS31685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J421_RS31695	COG2313	pseudouridylate synthase activity
J421_RS31735	COG1136	(ABC) transporter
J421_RS31735	COG0577	efflux transmembrane transporter activity
J421_RS31750	COG1136	(ABC) transporter
J421_RS31750	COG0577	efflux transmembrane transporter activity
J421_RS31780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J421_RS31800	COG1959	2 iron, 2 sulfur cluster binding
J421_RS31810	COG1695	Transcriptional regulator
J421_RS31820	COG0577	efflux transmembrane transporter activity
J421_RS31860	COG2252	PERMEase
J421_RS31880	COG2815	serine threonine protein kinase
J421_RS31880	COG0515	serine threonine protein kinase