locus-tag	class	description
E5Z46_RS00005	COG0316	Belongs to the HesB IscA family
E5Z46_RS00010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5Z46_RS00015	COG4844	belongs to the
E5Z46_RS00020	COG1252	NADH dehydrogenase
E5Z46_RS00025	COG4837	Protein of unknown function (DUF1462)
E5Z46_RS00030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5Z46_RS00040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5Z46_RS00045	COG0460	homoserine dehydrogenase
E5Z46_RS00055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5Z46_RS00060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5Z46_RS00065	COG0647	UMP catabolic process
E5Z46_RS00070	COG2445	Protein of unknown function DUF86
E5Z46_RS00085	COG4470	Protein conserved in bacteria
E5Z46_RS00095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5Z46_RS00100	COG0739	heme binding
E5Z46_RS00115	COG0411	ABC transporter
E5Z46_RS00140	COG3377	Domain of unknown function (DUF1805)
E5Z46_RS00145	COG0737	Belongs to the 5'-nucleotidase family
E5Z46_RS00150	COG0730	response to heat
E5Z46_RS00155	COG1801	Protein of unknown function DUF72
E5Z46_RS00160	COG1280	lysine exporter protein (LysE YggA)
E5Z46_RS00185	COG3344	reverse transcriptase
E5Z46_RS00195	COG0719	Fe-S assembly protein
E5Z46_RS00200	COG0822	iron-sulfur transferase activity
E5Z46_RS00205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5Z46_RS00210	COG0719	Fe-S assembly protein
E5Z46_RS00215	COG0396	ATPase activity
E5Z46_RS00220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5Z46_RS00235	COG1464	Belongs to the NlpA lipoprotein family
E5Z46_RS00240	COG2011	ABC-type metal ion transport system permease component
E5Z46_RS00245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Z46_RS00255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS00260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E5Z46_RS00270	COG0509	glycine decarboxylation via glycine cleavage system
E5Z46_RS00275	COG1393	Belongs to the ArsC family
E5Z46_RS00280	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS00285	COG0183	Belongs to the thiolase family
E5Z46_RS00290	COG1024	Enoyl-CoA hydratase
E5Z46_RS00290	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Z46_RS00300	COG0506	proline dehydrogenase activity
E5Z46_RS00310	COG5577	PFAM Coat F domain
E5Z46_RS00320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5Z46_RS00325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5Z46_RS00335	COG0469	pyruvate kinase activity
E5Z46_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS00415	COG0583	DNA-binding transcription factor activity
E5Z46_RS00420	COG3546	catalase activity
E5Z46_RS00440	COG2197	response regulator
E5Z46_RS00525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5Z46_RS00530	COG0557	exoribonuclease II activity
E5Z46_RS00540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5Z46_RS00550	COG2272	Belongs to the type-B carboxylesterase lipase family
E5Z46_RS00560	COG3344	reverse transcriptase
E5Z46_RS00570	COG0148	phosphopyruvate hydratase activity
E5Z46_RS00580	COG0149	triose-phosphate isomerase activity
E5Z46_RS00585	COG0126	phosphoglycerate kinase activity
E5Z46_RS00605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5Z46_RS00625	COG0740	serine-type endopeptidase activity
E5Z46_RS00630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Z46_RS00635	COG1481	regulation of sporulation
E5Z46_RS00640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5Z46_RS00645	COG1660	Displays ATPase and GTPase activities
E5Z46_RS00650	COG1051	belongs to the nudix hydrolase family
E5Z46_RS00655	COG0492	ferredoxin-NADP+ reductase activity
E5Z46_RS00660	COG0457	Tetratricopeptide repeat
E5Z46_RS00665	COG0140	phosphoribosyl-ATP diphosphatase activity
E5Z46_RS00665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5Z46_RS00670	COG0107	imidazoleglycerol-phosphate synthase activity
E5Z46_RS00675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5Z46_RS00680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5Z46_RS00685	COG0131	Imidazoleglycerol-phosphate dehydratase
E5Z46_RS00690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5Z46_RS00700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5Z46_RS00705	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5Z46_RS00710	COG0110	maltose O-acetyltransferase activity
E5Z46_RS00715	COG0546	phosphoglycolate phosphatase activity
E5Z46_RS00720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z46_RS00725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5Z46_RS00730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5Z46_RS00735	COG1950	PFAM Membrane protein of
E5Z46_RS00745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5Z46_RS00750	COG0556	nucleotide-excision repair
E5Z46_RS00755	COG4897	Protein conserved in bacteria
E5Z46_RS00760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Z46_RS00765	COG0789	Transcriptional regulator
E5Z46_RS00775	COG0463	Glycosyl transferase, family 2
E5Z46_RS00785	COG0793	Belongs to the peptidase S41A family
E5Z46_RS00785	COG3409	Peptidoglycan-binding domain 1 protein
E5Z46_RS00790	COG1741	Belongs to the pirin family
E5Z46_RS00830	COG2177	Part of the ABC transporter FtsEX involved in
E5Z46_RS00835	COG2884	Cell division ATP-binding protein ftsE
E5Z46_RS00845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Z46_RS00860	COG3344	reverse transcriptase
E5Z46_RS00875	COG0653	protein targeting
E5Z46_RS00905	COG1516	flagellar protein fliS
E5Z46_RS00910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E5Z46_RS00915	COG1334	flagellar protein FlaG
E5Z46_RS00960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5Z46_RS00970	COG2089	acid synthase
E5Z46_RS00975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5Z46_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5Z46_RS00980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5Z46_RS00985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5Z46_RS00990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Z46_RS00995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5Z46_RS01010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5Z46_RS01020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E5Z46_RS01025	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E5Z46_RS01035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5Z46_RS01040	COG4786	Flagellar basal body rod
E5Z46_RS01040	COG1256	bacterial-type flagellum assembly
E5Z46_RS01060	COG1728	Protein conserved in bacteria
E5Z46_RS01075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5Z46_RS01090	COG1040	competence protein
E5Z46_RS01095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E5Z46_RS01105	COG1307	EDD domain protein, DegV family
E5Z46_RS01110	COG2197	response regulator
E5Z46_RS01115	COG4585	Histidine kinase
E5Z46_RS01120	COG1739	Uncharacterized protein family UPF0029
E5Z46_RS01125	COG1316	TRANSCRIPTIONal
E5Z46_RS01130	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5Z46_RS01140	COG2247	cell wall binding repeat
E5Z46_RS01140	COG2385	sporulation resulting in formation of a cellular spore
E5Z46_RS01155	COG0438	transferase activity, transferring glycosyl groups
E5Z46_RS01190	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS01205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5Z46_RS01210	COG0653	protein targeting
E5Z46_RS01250	COG0737	Belongs to the 5'-nucleotidase family
E5Z46_RS01280	COG0737	Belongs to the 5'-nucleotidase family
E5Z46_RS01320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E5Z46_RS01335	COG1388	LysM domain
E5Z46_RS01335	COG0791	NLP P60 protein
E5Z46_RS01350	COG0629	single-stranded DNA binding
E5Z46_RS01360	COG3764	Sortase (surface protein transpeptidase)
E5Z46_RS01370	COG0527	aspartate kinase activity
E5Z46_RS01395	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS01405	COG0477	Major facilitator Superfamily
E5Z46_RS01410	COG1309	transcriptional regulator
E5Z46_RS01415	COG1940	carbohydrate kinase activity
E5Z46_RS01425	COG1175	transmembrane transport
E5Z46_RS01435	COG4753	response regulator
E5Z46_RS01435	COG2207	Transcriptional regulator
E5Z46_RS01440	COG2972	Histidine kinase
E5Z46_RS01455	COG1486	melibiose metabolic process
E5Z46_RS01465	COG2723	6-phospho-beta-galactosidase activity
E5Z46_RS01470	COG0277	FAD linked oxidase domain protein
E5Z46_RS01490	COG0346	lactoylglutathione lyase activity
E5Z46_RS01495	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS01505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Z46_RS01510	COG0798	PFAM Bile acid sodium symporter
E5Z46_RS01515	COG0640	Transcriptional regulator
E5Z46_RS01530	COG1879	ABC-type sugar transport system periplasmic component
E5Z46_RS01535	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS01540	COG1129	ABC transporter
E5Z46_RS01545	COG1869	D-ribose catabolic process
E5Z46_RS01550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Z46_RS01555	COG1609	Transcriptional regulator
E5Z46_RS01565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Z46_RS01590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5Z46_RS01600	COG1114	Component of the transport system for branched-chain amino acids
E5Z46_RS01605	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5Z46_RS01620	COG0653	protein targeting
E5Z46_RS01630	COG3012	SEC-C Motif Domain Protein
E5Z46_RS01630	COG1405	negative regulation of cell septum assembly
E5Z46_RS01645	COG1405	negative regulation of cell septum assembly
E5Z46_RS01645	COG3012	SEC-C Motif Domain Protein
E5Z46_RS01665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Z46_RS01665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5Z46_RS01670	COG3189	MarR family transcriptional regulator
E5Z46_RS01685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Z46_RS01690	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
E5Z46_RS01700	COG0395	ABC-type sugar transport system, permease component
E5Z46_RS01705	COG1175	transmembrane transport
E5Z46_RS01725	COG0697	spore germination
E5Z46_RS01740	COG1376	ErfK ybiS ycfS ynhG family protein
E5Z46_RS01865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Z46_RS01870	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5Z46_RS01890	COG0529	Catalyzes the synthesis of activated sulfate
E5Z46_RS01895	COG0471	metal ion transport
E5Z46_RS01895	COG3273	potassium ion transport
E5Z46_RS01900	COG2046	Belongs to the sulfate adenylyltransferase family
E5Z46_RS01905	COG2244	polysaccharide biosynthetic process
E5Z46_RS01935	COG1215	transferase activity, transferring glycosyl groups
E5Z46_RS01945	COG0438	transferase activity, transferring glycosyl groups
E5Z46_RS01990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5Z46_RS01995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5Z46_RS02000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Z46_RS02020	COG4464	protein tyrosine phosphatase activity
E5Z46_RS02025	COG1316	TRANSCRIPTIONal
E5Z46_RS02035	COG0489	protein tyrosine kinase activity
E5Z46_RS02040	COG3944	biosynthesis protein
E5Z46_RS02050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5Z46_RS02060	COG4786	Flagellar basal body rod
E5Z46_RS02065	COG4786	Flagellar basal body rod
E5Z46_RS02070	COG1077	Cell shape determining protein MreB Mrl
E5Z46_RS02075	COG1609	Transcriptional regulator
E5Z46_RS02085	COG2059	Chromate
E5Z46_RS02090	COG2059	Chromate
E5Z46_RS02100	COG4608	Belongs to the ABC transporter superfamily
E5Z46_RS02105	COG0444	Belongs to the ABC transporter superfamily
E5Z46_RS02110	COG0747	negative chemotaxis
E5Z46_RS02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5Z46_RS02120	COG0601	transmembrane transport
E5Z46_RS02125	COG1522	sequence-specific DNA binding
E5Z46_RS02130	COG0739	heme binding
E5Z46_RS02135	COG2385	sporulation resulting in formation of a cellular spore
E5Z46_RS02140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5Z46_RS02150	COG4836	Membrane
E5Z46_RS02155	COG1007	ATP synthesis coupled electron transport
E5Z46_RS02165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Z46_RS02170	COG0713	ATP synthesis coupled electron transport
E5Z46_RS02175	COG0839	Belongs to the complex I subunit 6 family
E5Z46_RS02180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Z46_RS02185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5Z46_RS02190	COG0649	NAD binding
E5Z46_RS02195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Z46_RS02200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Z46_RS02205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Z46_RS02210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5Z46_RS02215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5Z46_RS02220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5Z46_RS02225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5Z46_RS02230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5Z46_RS02235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5Z46_RS02245	COG0356	it plays a direct role in the translocation of protons across the membrane
E5Z46_RS02265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5Z46_RS02270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5Z46_RS02275	COG4475	Protein of unknown function (DUF436)
E5Z46_RS02280	COG0698	ribose 5-phosphate isomerase
E5Z46_RS02285	COG0840	transmembrane signaling receptor activity
E5Z46_RS02295	COG1971	Probably functions as a manganese efflux pump
E5Z46_RS02305	COG0009	L-threonylcarbamoyladenylate synthase
E5Z46_RS02320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5Z46_RS02335	COG1435	thymidine kinase activity
E5Z46_RS02340	COG3344	reverse transcriptase
E5Z46_RS02350	COG3344	reverse transcriptase
E5Z46_RS02360	COG0254	rRNA binding
E5Z46_RS02365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5Z46_RS02375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5Z46_RS02380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5Z46_RS02390	COG2204	response regulator
E5Z46_RS02395	COG4821	SIS domain
E5Z46_RS02400	COG0504	CTP synthase activity
E5Z46_RS02405	COG3343	RNA polymerase activity
E5Z46_RS02420	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS02425	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS02430	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Z46_RS02440	COG0183	Belongs to the thiolase family
E5Z46_RS02445	COG2181	nitrate reductase activity
E5Z46_RS02445	COG0247	lactate metabolic process
E5Z46_RS02450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Z46_RS02460	COG0018	arginyl-trna synthetase
E5Z46_RS02475	COG0010	Belongs to the arginase family
E5Z46_RS02480	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5Z46_RS02485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Z46_RS02495	COG1994	Peptidase M50
E5Z46_RS02500	COG1942	4-Oxalocrotonate Tautomerase
E5Z46_RS02505	COG2252	PERMEase
E5Z46_RS02510	COG3465	dGTPase activity
E5Z46_RS02515	COG1078	dGTPase activity
E5Z46_RS02520	COG4844	belongs to the
E5Z46_RS02530	COG0095	Lipoate-protein ligase
E5Z46_RS02535	COG0280	phosphate acetyltransferase
E5Z46_RS02540	COG3253	May function as heme-dependent peroxidase
E5Z46_RS02545	COG3773	Cell wall hydrolase
E5Z46_RS02560	COG1575	Belongs to the MenA family. Type 1 subfamily
E5Z46_RS02565	COG2363	Small membrane protein
E5Z46_RS02575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5Z46_RS02585	COG1366	Belongs to the anti-sigma-factor antagonist family
E5Z46_RS02590	COG2172	sigma factor antagonist activity
E5Z46_RS02595	COG1191	sigma factor activity
E5Z46_RS02600	COG2208	phosphoserine phosphatase activity
E5Z46_RS02605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5Z46_RS02620	COG1216	Glycosyl transferase, family 2
E5Z46_RS02625	COG0477	Major facilitator Superfamily
E5Z46_RS02645	COG2801	Transposase and inactivated derivatives
E5Z46_RS02670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Z46_RS02675	COG0573	inorganic phosphate transmembrane transporter activity
E5Z46_RS02680	COG0581	inorganic phosphate transmembrane transporter activity
E5Z46_RS02685	COG3547	Transposase (IS116 IS110 IS902 family)
E5Z46_RS02695	COG2190	(PTS) system
E5Z46_RS02705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E5Z46_RS02705	COG2508	Transcriptional regulator
E5Z46_RS02710	COG0686	Belongs to the AlaDH PNT family
E5Z46_RS02715	COG4636	protein conserved in cyanobacteria
E5Z46_RS02720	COG0351	phosphomethylpyrimidine kinase
E5Z46_RS02725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Z46_RS02725	COG3153	acetyltransferase
E5Z46_RS02730	COG3344	reverse transcriptase
E5Z46_RS02740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Z46_RS02750	COG0765	amino acid transport
E5Z46_RS02760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5Z46_RS02770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5Z46_RS02775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5Z46_RS02785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Z46_RS02800	COG0723	plastoquinol--plastocyanin reductase activity
E5Z46_RS02800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Z46_RS02805	COG1482	cell wall glycoprotein biosynthetic process
E5Z46_RS02810	COG1929	Belongs to the glycerate kinase type-1 family
E5Z46_RS02815	COG2199	diguanylate cyclase activity
E5Z46_RS02820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Z46_RS02825	COG1442	glycosyl transferase family 8
E5Z46_RS02830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5Z46_RS02840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Z46_RS02845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5Z46_RS02850	COG4853	Protein conserved in bacteria
E5Z46_RS02855	COG4863	YycH protein
E5Z46_RS02860	COG5002	protein histidine kinase activity
E5Z46_RS02865	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS02870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5Z46_RS02875	COG0305	Participates in initiation and elongation during chromosome replication
E5Z46_RS02880	COG0359	binds to the 23S rRNA
E5Z46_RS02885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E5Z46_RS02890	COG4241	membrane
E5Z46_RS02895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5Z46_RS02900	COG0629	single-stranded DNA binding
E5Z46_RS02905	COG0360	Binds together with S18 to 16S ribosomal RNA
E5Z46_RS02910	COG0012	GTP binding
E5Z46_RS02915	COG0243	molybdopterin cofactor binding
E5Z46_RS02920	COG4481	Protein conserved in bacteria
E5Z46_RS02925	COG0668	transmembrane transport
E5Z46_RS02940	COG1475	DNA binding
E5Z46_RS02945	COG1192	Involved in chromosome partitioning
E5Z46_RS02950	COG1475	DNA binding
E5Z46_RS02955	COG0357	Ribosomal RNA small subunit methyltransferase G
E5Z46_RS02960	COG0445	tRNA wobble uridine modification
E5Z46_RS02965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5Z46_RS02970	COG1847	R3H domain protein
E5Z46_RS02975	COG0706	membrane insertase activity
E5Z46_RS02980	COG0594	ribonuclease P activity
E5Z46_RS02985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5Z46_RS02995	COG0592	DNA-directed DNA polymerase activity
E5Z46_RS03005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5Z46_RS03010	COG0187	DNA topoisomerase II activity
E5Z46_RS03015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5Z46_RS03020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5Z46_RS03055	COG0517	IMP dehydrogenase activity
E5Z46_RS03055	COG0516	GMP reductase activity
E5Z46_RS03070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E5Z46_RS03075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5Z46_RS03080	COG1388	LysM domain
E5Z46_RS03080	COG3858	chitin binding
E5Z46_RS03085	COG0590	tRNA wobble adenosine to inosine editing
E5Z46_RS03095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Z46_RS03100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5Z46_RS03105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5Z46_RS03150	COG1982	Orn Lys Arg decarboxylase major
E5Z46_RS03155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5Z46_RS03160	COG0470	DNA polymerase III
E5Z46_RS03165	COG1774	PSP1 C-terminal conserved region
E5Z46_RS03170	COG4467	Involved in initiation control of chromosome replication
E5Z46_RS03175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5Z46_RS03180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5Z46_RS03185	COG2002	toxin-antitoxin pair type II binding
E5Z46_RS03195	COG0084	hydrolase, TatD family'
E5Z46_RS03200	COG3583	domain protein
E5Z46_RS03200	COG3584	3D domain protein
E5Z46_RS03210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5Z46_RS03220	COG4466	Protein conserved in bacteria
E5Z46_RS03235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5Z46_RS03240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Z46_RS03245	COG0251	oxidation-reduction process
E5Z46_RS03250	COG2088	sporulation resulting in formation of a cellular spore
E5Z46_RS03255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5Z46_RS03265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5Z46_RS03270	COG0193	aminoacyl-tRNA hydrolase activity
E5Z46_RS03280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5Z46_RS03285	COG2002	toxin-antitoxin pair type II binding
E5Z46_RS03290	COG2244	polysaccharide biosynthetic process
E5Z46_RS03295	COG3956	TIGRFAM MazG family protein
E5Z46_RS03300	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5Z46_RS03315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5Z46_RS03320	COG1098	S1 RNA binding domain
E5Z46_RS03335	COG2208	phosphoserine phosphatase activity
E5Z46_RS03340	COG2304	oxidoreductase activity
E5Z46_RS03345	COG0515	serine threonine protein kinase
E5Z46_RS03350	COG0037	tRNA processing
E5Z46_RS03355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E5Z46_RS03360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Z46_RS03365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5Z46_RS03370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5Z46_RS03375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Z46_RS03380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5Z46_RS03385	COG0512	Glutamine amidotransferase of anthranilate synthase
E5Z46_RS03390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5Z46_RS03395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5Z46_RS03400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5Z46_RS03405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5Z46_RS03410	COG1396	sequence-specific DNA binding
E5Z46_RS03415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5Z46_RS03490	COG3880	PFAM UvrB UvrC protein
E5Z46_RS03495	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E5Z46_RS03500	COG0542	response to heat
E5Z46_RS03505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5Z46_RS03510	COG4956	integral membrane protein (PIN domain superfamily)
E5Z46_RS03515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5Z46_RS03520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5Z46_RS03525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Z46_RS03530	COG1045	serine acetyltransferase
E5Z46_RS03535	COG0215	cysteine-tRNA ligase activity
E5Z46_RS03545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Z46_RS03550	COG3688	RNA-binding protein containing a PIN domain
E5Z46_RS03560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5Z46_RS03565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5Z46_RS03570	COG0250	Participates in transcription elongation, termination and antitermination
E5Z46_RS03575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5Z46_RS03580	COG0081	regulation of translation
E5Z46_RS03585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5Z46_RS03590	COG0222	ribosome binding
E5Z46_RS03595	COG2813	Specifically methylates the guanine in position
E5Z46_RS03600	COG0085	RNA polymerase activity
E5Z46_RS03605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5Z46_RS03610	COG1358	cellular component organization or biogenesis
E5Z46_RS03615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5Z46_RS03620	COG0049	tRNA binding
E5Z46_RS03625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5Z46_RS03630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5Z46_RS03640	COG0051	transcription antitermination factor activity, RNA binding
E5Z46_RS03645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5Z46_RS03650	COG0088	Forms part of the polypeptide exit tunnel
E5Z46_RS03655	COG0089	rRNA binding
E5Z46_RS03660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5Z46_RS03665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5Z46_RS03670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5Z46_RS03675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5Z46_RS03680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5Z46_RS03690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5Z46_RS03705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5Z46_RS03710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5Z46_RS03715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5Z46_RS03725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5Z46_RS03730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5Z46_RS03745	COG0201	protein transport
E5Z46_RS03750	COG0563	adenylate kinase activity
E5Z46_RS03755	COG0024	Methionine aminopeptidase
E5Z46_RS03760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5Z46_RS03765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5Z46_RS03770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5Z46_RS03775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5Z46_RS03780	COG0202	RNA polymerase activity
E5Z46_RS03785	COG0203	ribosomal protein L17
E5Z46_RS03790	COG1122	ATPase activity
E5Z46_RS03795	COG1122	ATPase activity
E5Z46_RS03800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5Z46_RS03805	COG0101	tRNA pseudouridine synthase activity
E5Z46_RS03810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5Z46_RS03825	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5Z46_RS03830	COG0489	protein tyrosine kinase activity
E5Z46_RS03840	COG2194	sulfuric ester hydrolase activity
E5Z46_RS03845	COG0726	polysaccharide deacetylase
E5Z46_RS03905	COG1595	DNA-templated transcription, initiation
E5Z46_RS03910	COG5662	AntiSigma factor
E5Z46_RS03915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E5Z46_RS03920	COG4856	YbbR-like protein
E5Z46_RS03925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Z46_RS03930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5Z46_RS03935	COG2207	Transcriptional regulator
E5Z46_RS03955	COG0662	Cupin 2, conserved barrel domain protein
E5Z46_RS03975	COG1064	alcohol dehydrogenase
E5Z46_RS03985	COG2814	Major facilitator Superfamily
E5Z46_RS04005	COG3655	Transcriptional regulator
E5Z46_RS04010	COG3739	integral membrane protein
E5Z46_RS04015	COG2318	DinB family
E5Z46_RS04020	COG0084	hydrolase, TatD family'
E5Z46_RS04025	COG3829	transcription factor binding
E5Z46_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS04040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5Z46_RS04045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Z46_RS04050	COG0586	Pfam SNARE associated Golgi protein
E5Z46_RS04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS04065	COG4607	ABC-type enterochelin transport system periplasmic component
E5Z46_RS04070	COG1120	ATPase activity
E5Z46_RS04075	COG3829	transcription factor binding
E5Z46_RS04075	COG3290	protein histidine kinase activity
E5Z46_RS04080	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS04105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5Z46_RS04115	COG3344	reverse transcriptase
E5Z46_RS04120	COG2318	DinB family
E5Z46_RS04130	COG2197	response regulator
E5Z46_RS04160	COG1404	Belongs to the peptidase S8 family
E5Z46_RS04165	COG1368	sulfuric ester hydrolase activity
E5Z46_RS04170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5Z46_RS04175	COG0531	amino acid
E5Z46_RS04180	COG1971	Probably functions as a manganese efflux pump
E5Z46_RS04190	COG5577	PFAM Coat F domain
E5Z46_RS04195	COG1940	carbohydrate kinase activity
E5Z46_RS04200	COG1968	undecaprenyl-diphosphatase activity
E5Z46_RS04210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5Z46_RS04220	COG0586	Pfam SNARE associated Golgi protein
E5Z46_RS04225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5Z46_RS04230	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5Z46_RS04235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Z46_RS04245	COG0513	Belongs to the DEAD box helicase family
E5Z46_RS04250	COG0705	Rhomboid family
E5Z46_RS04255	COG0736	holo-[acyl-carrier-protein] synthase activity
E5Z46_RS04260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5Z46_RS04265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5Z46_RS04270	COG0864	Transcriptional regulator
E5Z46_RS04275	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5Z46_RS04280	COG2183	response to ionizing radiation
E5Z46_RS04290	COG3091	SprT-like family
E5Z46_RS04365	COG0802	atpase or kinase
E5Z46_RS04375	COG0456	acetyltransferase
E5Z46_RS04390	COG3344	reverse transcriptase
E5Z46_RS04420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5Z46_RS04425	COG0805	protein transport
E5Z46_RS04435	COG1266	CAAX protease self-immunity
E5Z46_RS04445	COG0459	protein refolding
E5Z46_RS04460	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
E5Z46_RS04465	COG1305	Transglutaminase-like
E5Z46_RS04470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5Z46_RS04470	COG0519	Catalyzes the synthesis of GMP from XMP
E5Z46_RS04475	COG2252	PERMEase
E5Z46_RS04480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5Z46_RS04505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5Z46_RS04510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5Z46_RS04515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5Z46_RS04520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5Z46_RS04525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Z46_RS04530	COG0047	phosphoribosylformylglycinamidine synthase activity
E5Z46_RS04535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Z46_RS04540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5Z46_RS04545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5Z46_RS04550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5Z46_RS04555	COG0138	bifunctional purine biosynthesis protein purh
E5Z46_RS04560	COG0151	Belongs to the GarS family
E5Z46_RS04570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5Z46_RS04575	COG1470	cell adhesion involved in biofilm formation
E5Z46_RS04580	COG4496	protein, YerC YecD
E5Z46_RS04585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E5Z46_RS04595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Z46_RS04600	COG4851	CamS sex pheromone cAM373 precursor
E5Z46_RS04610	COG1611	Belongs to the LOG family
E5Z46_RS04635	COG0154	amidase activity
E5Z46_RS04640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Z46_RS04685	COG1131	(ABC) transporter
E5Z46_RS04750	COG5002	protein histidine kinase activity
E5Z46_RS04770	COG1131	(ABC) transporter
E5Z46_RS04775	COG1174	glycine betaine transport
E5Z46_RS04780	COG1125	glycine betaine transport
E5Z46_RS04780	COG0517	IMP dehydrogenase activity
E5Z46_RS04785	COG1732	Glycine betaine
E5Z46_RS04905	COG3547	Transposase (IS116 IS110 IS902 family)
E5Z46_RS04910	COG1653	transport
E5Z46_RS04915	COG1175	transmembrane transport
E5Z46_RS04920	COG0395	ABC-type sugar transport system, permease component
E5Z46_RS04925	COG3842	ATPase activity
E5Z46_RS04950	COG0789	Transcriptional regulator
E5Z46_RS05025	COG2814	Major facilitator Superfamily
E5Z46_RS05045	COG1511	domain protein
E5Z46_RS05055	COG5002	protein histidine kinase activity
E5Z46_RS05075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Z46_RS05085	COG0501	Belongs to the peptidase M48B family
E5Z46_RS05105	COG2268	Band 7 protein
E5Z46_RS05110	COG1597	lipid kinase activity
E5Z46_RS05115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5Z46_RS05155	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E5Z46_RS05165	COG3344	reverse transcriptase
E5Z46_RS05180	COG1959	2 iron, 2 sulfur cluster binding
E5Z46_RS05185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5Z46_RS05190	COG4326	sporulation control protein
E5Z46_RS05195	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS05200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5Z46_RS05205	COG0297	glycogen (starch) synthase activity
E5Z46_RS05220	COG2197	response regulator
E5Z46_RS05230	COG1366	Belongs to the anti-sigma-factor antagonist family
E5Z46_RS05240	COG1714	RDD family
E5Z46_RS05245	COG3290	protein histidine kinase activity
E5Z46_RS05245	COG0840	transmembrane signaling receptor activity
E5Z46_RS05250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5Z46_RS05255	COG0436	Aminotransferase
E5Z46_RS05260	COG0028	Belongs to the TPP enzyme family
E5Z46_RS05265	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS05275	COG2814	Major facilitator Superfamily
E5Z46_RS05280	COG0789	Transcriptional regulator
E5Z46_RS05295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5Z46_RS05305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5Z46_RS05325	COG2986	histidine ammonia-lyase
E5Z46_RS05330	COG0861	Integral membrane protein TerC family
E5Z46_RS05365	COG1556	Lactate utilization protein
E5Z46_RS05370	COG1139	Iron-sulfur cluster binding protein
E5Z46_RS05375	COG0247	lactate metabolic process
E5Z46_RS05380	COG2186	Transcriptional regulator
E5Z46_RS05385	COG1620	l-lactate permease
E5Z46_RS05390	COG1077	Cell shape determining protein MreB Mrl
E5Z46_RS05395	COG0791	NLP P60 protein
E5Z46_RS05395	COG1388	LysM domain
E5Z46_RS05415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5Z46_RS05415	COG1648	precorrin-2 dehydrogenase activity
E5Z46_RS05420	COG0384	phenazine biosynthesis protein PhzF
E5Z46_RS05430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5Z46_RS05435	COG0010	Belongs to the arginase family
E5Z46_RS05445	COG1254	Belongs to the acylphosphatase family
E5Z46_RS05460	COG0529	Catalyzes the synthesis of activated sulfate
E5Z46_RS05465	COG2046	Belongs to the sulfate adenylyltransferase family
E5Z46_RS05475	COG0175	sulfate reduction
E5Z46_RS05480	COG4840	Belongs to the UPF0435 family
E5Z46_RS05485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Z46_RS05490	COG1295	ribonuclease BN
E5Z46_RS05500	COG0477	Major facilitator Superfamily
E5Z46_RS05505	COG0387	Pfam Sodium calcium exchanger
E5Z46_RS05515	COG0535	radical SAM domain protein
E5Z46_RS05535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E5Z46_RS05565	COG4758	membrane
E5Z46_RS05570	COG4585	Histidine kinase
E5Z46_RS05575	COG2197	response regulator
E5Z46_RS05580	COG2197	response regulator
E5Z46_RS05590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5Z46_RS05600	COG0789	Transcriptional regulator
E5Z46_RS05615	COG5609	conserved protein (DUF2294)
E5Z46_RS05620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Z46_RS05625	COG3002	Belongs to the UPF0753 family
E5Z46_RS05635	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS05645	COG1442	glycosyl transferase family 8
E5Z46_RS05665	COG1090	epimerase
E5Z46_RS05670	COG2137	regulation of response to DNA damage stimulus
E5Z46_RS05695	COG2427	Protein of unknown function (DUF1641)
E5Z46_RS05700	COG3383	formate dehydrogenase (NAD+) activity
E5Z46_RS05705	COG5609	conserved protein (DUF2294)
E5Z46_RS05710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5Z46_RS05715	COG2223	nitrite transmembrane transporter activity
E5Z46_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS05745	COG3557	Belongs to the UPF0374 family
E5Z46_RS05750	COG0444	Belongs to the ABC transporter superfamily
E5Z46_RS05755	COG4608	Belongs to the ABC transporter superfamily
E5Z46_RS05760	COG0747	negative chemotaxis
E5Z46_RS05765	COG0601	transmembrane transport
E5Z46_RS05770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5Z46_RS05780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5Z46_RS05785	COG4555	ABC transporter
E5Z46_RS05800	COG0039	L-malate dehydrogenase activity
E5Z46_RS05810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5Z46_RS05815	COG0735	belongs to the Fur family
E5Z46_RS05950	COG3382	B3 4 domain protein
E5Z46_RS05970	COG2766	serine protein kinase
E5Z46_RS05985	COG2856	Zn peptidase
E5Z46_RS05990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Z46_RS05995	COG2176	DNA-directed DNA polymerase activity
E5Z46_RS06000	COG1396	sequence-specific DNA binding
E5Z46_RS06095	COG0582	viral genome integration into host DNA
E5Z46_RS06115	COG1802	Transcriptional regulator
E5Z46_RS06115	COG4626	Terminase
E5Z46_RS06180	COG1652	LysM domain
E5Z46_RS06195	COG3628	GPW Gp25 family protein
E5Z46_RS06200	COG3299	homolog of phage Mu protein gp47
E5Z46_RS06220	COG3778	Protein conserved in bacteria
E5Z46_RS06240	COG1876	peptidase activity
E5Z46_RS06255	COG1396	sequence-specific DNA binding
E5Z46_RS06265	COG1674	ftsk spoiiie
E5Z46_RS06295	COG3290	protein histidine kinase activity
E5Z46_RS06300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5Z46_RS06305	COG1301	dicarboxylic acid transport
E5Z46_RS06315	COG3344	reverse transcriptase
E5Z46_RS06320	COG0656	L-ascorbic acid biosynthetic process
E5Z46_RS06325	COG2738	Putative neutral zinc metallopeptidase
E5Z46_RS06330	COG1253	flavin adenine dinucleotide binding
E5Z46_RS06340	COG3344	reverse transcriptase
E5Z46_RS06345	COG0564	pseudouridine synthase activity
E5Z46_RS06365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5Z46_RS06370	COG0517	IMP dehydrogenase activity
E5Z46_RS06375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Z46_RS06385	COG3344	reverse transcriptase
E5Z46_RS06400	COG0586	Pfam SNARE associated Golgi protein
E5Z46_RS06405	COG2719	SpoVR family
E5Z46_RS06430	COG0640	Transcriptional regulator
E5Z46_RS06440	COG2072	flavoprotein involved in K transport
E5Z46_RS06465	COG0640	Transcriptional regulator
E5Z46_RS06475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Z46_RS06480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5Z46_RS06490	COG2226	methyltransferase
E5Z46_RS06495	COG1247	-acetyltransferase
E5Z46_RS06505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5Z46_RS06505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Z46_RS06520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Z46_RS06565	COG1271	oxidase subunit
E5Z46_RS06570	COG1294	oxidase, subunit
E5Z46_RS06580	COG2076	Multidrug Resistance protein
E5Z46_RS06590	COG0861	Integral membrane protein TerC family
E5Z46_RS06600	COG1966	Carbon starvation protein
E5Z46_RS06605	COG2879	small protein
E5Z46_RS06615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5Z46_RS06620	COG0366	Alpha amylase catalytic
E5Z46_RS06625	COG2318	DinB family
E5Z46_RS06640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5Z46_RS06655	COG4721	ABC-type cobalt transport system, permease component
E5Z46_RS06660	COG1122	ATPase activity
E5Z46_RS06665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5Z46_RS06670	COG0352	thiamine-phosphate diphosphorylase activity
E5Z46_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Z46_RS06685	COG2022	thiamine diphosphate biosynthetic process
E5Z46_RS06690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5Z46_RS06705	COG1253	flavin adenine dinucleotide binding
E5Z46_RS06720	COG3842	ATPase activity
E5Z46_RS06725	COG2508	Transcriptional regulator
E5Z46_RS06745	COG0189	ligase activity
E5Z46_RS06750	COG0189	ligase activity
E5Z46_RS06760	COG4399	Belongs to the UPF0754 family
E5Z46_RS06765	COG3679	Belongs to the UPF0342 family
E5Z46_RS06770	COG0561	phosphatase activity
E5Z46_RS06780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Z46_RS06805	COG3481	metal-dependent phosphohydrolase, HD sub domain
E5Z46_RS06820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5Z46_RS06835	COG1846	Transcriptional regulator
E5Z46_RS06855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Z46_RS06860	COG0537	adenosine 5'-monophosphoramidase activity
E5Z46_RS06865	COG1131	(ABC) transporter
E5Z46_RS06870	COG4473	ABC transporter
E5Z46_RS06875	COG3069	C4-dicarboxylate transmembrane transporter activity
E5Z46_RS06880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5Z46_RS06885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5Z46_RS06895	COG1309	transcriptional regulator
E5Z46_RS06900	COG1511	domain protein
E5Z46_RS06910	COG1234	tRNA 3'-trailer cleavage
E5Z46_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS06930	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E5Z46_RS06940	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5Z46_RS06955	COG2224	Isocitrate lyase
E5Z46_RS06965	COG4903	ComK protein
E5Z46_RS06970	COG0398	Pfam SNARE associated Golgi protein
E5Z46_RS06990	COG1074	ATP-dependent DNA helicase activity
E5Z46_RS06995	COG0420	3'-5' exonuclease activity
E5Z46_RS07000	COG0419	ATPase involved in DNA repair
E5Z46_RS07050	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS07055	COG2311	Membrane
E5Z46_RS07065	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5Z46_RS07090	COG0367	asparagine synthase
E5Z46_RS07095	COG0534	Mate efflux family protein
E5Z46_RS07100	COG1917	Cupin 2, conserved barrel domain protein
E5Z46_RS07100	COG2207	Transcriptional regulator
E5Z46_RS07110	COG2182	Extracellular solute-binding protein
E5Z46_RS07115	COG1175	transmembrane transport
E5Z46_RS07120	COG3833	ABC-type maltose transport systems, permease component
E5Z46_RS07125	COG0366	Alpha amylase catalytic
E5Z46_RS07140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5Z46_RS07145	COG0022	dehydrogenase e1 component
E5Z46_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS07170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5Z46_RS07170	COG0646	methionine synthase
E5Z46_RS07180	COG3842	ATPase activity
E5Z46_RS07185	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5Z46_RS07190	COG1177	transmembrane transport
E5Z46_RS07195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5Z46_RS07225	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS07255	COG4555	ABC transporter
E5Z46_RS07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Z46_RS07270	COG1280	lysine exporter protein (LysE YggA)
E5Z46_RS07280	COG1666	GTP binding
E5Z46_RS07290	COG3177	Filamentation induced by cAMP protein fic
E5Z46_RS07295	COG1307	EDD domain protein, DegV family
E5Z46_RS07310	COG0561	phosphatase activity
E5Z46_RS07315	COG1073	alpha beta
E5Z46_RS07340	COG2151	metal-sulfur cluster biosynthetic enzyme
E5Z46_RS07360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5Z46_RS07390	COG0746	molybdenum cofactor guanylyltransferase activity
E5Z46_RS07395	COG0535	radical SAM domain protein
E5Z46_RS07425	COG2223	nitrite transmembrane transporter activity
E5Z46_RS07435	COG3344	reverse transcriptase
E5Z46_RS07445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5Z46_RS07450	COG4149	molybdate abc transporter
E5Z46_RS07455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5Z46_RS07460	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E5Z46_RS07470	COG0303	'Molybdopterin
E5Z46_RS07475	COG1763	Mo-molybdopterin cofactor biosynthetic process
E5Z46_RS07480	COG0314	molybdopterin synthase activity
E5Z46_RS07485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E5Z46_RS07550	COG3848	Pyruvate phosphate dikinase
E5Z46_RS07550	COG0574	Belongs to the PEP-utilizing enzyme family
E5Z46_RS07560	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5Z46_RS07615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5Z46_RS07630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Z46_RS07670	COG2267	carboxylic ester hydrolase activity
E5Z46_RS07685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5Z46_RS07690	COG5504	Zn-dependent protease
E5Z46_RS07715	COG4166	transmembrane transport
E5Z46_RS07720	COG0601	transmembrane transport
E5Z46_RS07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5Z46_RS07730	COG0444	Belongs to the ABC transporter superfamily
E5Z46_RS07735	COG4608	Belongs to the ABC transporter superfamily
E5Z46_RS07745	COG1393	Belongs to the ArsC family
E5Z46_RS07750	COG0861	Integral membrane protein TerC family
E5Z46_RS07755	COG4862	establishment of competence for transformation
E5Z46_RS07760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Z46_RS07770	COG1164	Oligoendopeptidase f
E5Z46_RS07780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5Z46_RS07785	COG2346	COG2346, Truncated hemoglobins
E5Z46_RS07790	COG0741	lytic transglycosylase activity
E5Z46_RS07795	COG4116	CYTH
E5Z46_RS07805	COG2357	RelA SpoT domain protein
E5Z46_RS07815	COG0564	pseudouridine synthase activity
E5Z46_RS07820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Z46_RS07825	COG0772	Belongs to the SEDS family
E5Z46_RS07855	COG0438	transferase activity, transferring glycosyl groups
E5Z46_RS07860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5Z46_RS07865	COG0438	transferase activity, transferring glycosyl groups
E5Z46_RS07870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5Z46_RS07875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5Z46_RS07940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5Z46_RS07955	COG2323	membrane
E5Z46_RS07960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS07980	COG2153	protein acetylation
E5Z46_RS07985	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E5Z46_RS07990	COG2382	esterase
E5Z46_RS08000	COG0626	cystathionine gamma-synthase activity
E5Z46_RS08005	COG0626	cystathionine gamma-synthase activity
E5Z46_RS08010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5Z46_RS08040	COG0840	transmembrane signaling receptor activity
E5Z46_RS08040	COG3290	protein histidine kinase activity
E5Z46_RS08110	COG0583	DNA-binding transcription factor activity
E5Z46_RS08120	COG2723	6-phospho-beta-galactosidase activity
E5Z46_RS08170	COG1937	Protein conserved in bacteria
E5Z46_RS08175	COG2217	Heavy metal translocating P-type atpase
E5Z46_RS08180	COG2608	mercury ion transmembrane transporter activity
E5Z46_RS08195	COG2132	Multicopper oxidase
E5Z46_RS08200	COG4990	cell redox homeostasis
E5Z46_RS08205	COG0367	asparagine synthase
E5Z46_RS08230	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Z46_RS08240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS08245	COG4585	Histidine kinase
E5Z46_RS08250	COG2197	response regulator
E5Z46_RS08255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS08270	COG0785	Cytochrome C biogenesis protein
E5Z46_RS08275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS08285	COG3858	chitin binding
E5Z46_RS08285	COG1388	LysM domain
E5Z46_RS08290	COG2210	Belongs to the sulfur carrier protein TusA family
E5Z46_RS08300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS08300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS08305	COG2226	methyltransferase
E5Z46_RS08315	COG1937	Protein conserved in bacteria
E5Z46_RS08320	COG0425	Belongs to the sulfur carrier protein TusA family
E5Z46_RS08325	COG2210	Belongs to the sulfur carrier protein TusA family
E5Z46_RS08330	COG1054	Belongs to the UPF0176 family
E5Z46_RS08335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS08340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS08340	COG0425	Belongs to the sulfur carrier protein TusA family
E5Z46_RS08345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS08345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS08350	COG0730	response to heat
E5Z46_RS08360	COG1418	mRNA catabolic process
E5Z46_RS08385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5Z46_RS08390	COG1597	lipid kinase activity
E5Z46_RS08400	COG2966	Psort location CytoplasmicMembrane, score
E5Z46_RS08410	COG1473	amidohydrolase
E5Z46_RS08420	COG4948	Mandelate Racemase Muconate Lactonizing
E5Z46_RS08425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Z46_RS08430	COG3162	membrane
E5Z46_RS08435	COG0531	amino acid
E5Z46_RS08455	COG3344	reverse transcriptase
E5Z46_RS08465	COG2814	Major facilitator Superfamily
E5Z46_RS08480	COG5002	protein histidine kinase activity
E5Z46_RS08485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5Z46_RS08490	COG4214	carbohydrate transport
E5Z46_RS08495	COG1129	ABC transporter
E5Z46_RS08505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E5Z46_RS08510	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
E5Z46_RS08515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Z46_RS08520	COG0436	Aminotransferase
E5Z46_RS08525	COG1850	ribulose-bisphosphate carboxylase activity
E5Z46_RS08530	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
E5Z46_RS08535	COG0235	Class ii aldolase
E5Z46_RS08540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E5Z46_RS08550	COG1846	Transcriptional regulator
E5Z46_RS08555	COG4869	propanediol catabolic process
E5Z46_RS08565	COG4946	Tricorn protease homolog
E5Z46_RS08565	COG0823	Involved in the tonB-independent uptake of proteins
E5Z46_RS08565	COG1506	peptidase
E5Z46_RS08570	COG0531	amino acid
E5Z46_RS08585	COG1131	(ABC) transporter
E5Z46_RS08610	COG0542	response to heat
E5Z46_RS08620	COG3949	Membrane
E5Z46_RS08625	COG0840	transmembrane signaling receptor activity
E5Z46_RS08645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5Z46_RS08650	COG0720	synthase
E5Z46_RS08660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5Z46_RS08665	COG0702	epimerase
E5Z46_RS08670	COG4873	Protein conserved in bacteria
E5Z46_RS08675	COG3773	Cell wall hydrolase
E5Z46_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS08700	COG4191	Histidine kinase
E5Z46_RS08705	COG0475	glutathione-regulated potassium exporter activity
E5Z46_RS08710	COG0596	Alpha beta hydrolase
E5Z46_RS08715	COG3711	transcriptional antiterminator
E5Z46_RS08720	COG2190	(PTS) system
E5Z46_RS08720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Z46_RS08720	COG1263	PTS System
E5Z46_RS08740	COG0456	acetyltransferase
E5Z46_RS08790	COG3209	COG3209 Rhs family protein
E5Z46_RS08835	COG2801	Transposase and inactivated derivatives
E5Z46_RS08865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5Z46_RS08910	COG0456	acetyltransferase
E5Z46_RS08920	COG0840	transmembrane signaling receptor activity
E5Z46_RS08930	COG0567	Dehydrogenase, E1 component
E5Z46_RS08935	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5Z46_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS08950	COG2084	Dehydrogenase
E5Z46_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS08965	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS08990	COG0436	Aminotransferase
E5Z46_RS09000	COG0598	Magnesium transport protein CorA
E5Z46_RS09020	COG1215	transferase activity, transferring glycosyl groups
E5Z46_RS09030	COG1408	metallophosphoesterase
E5Z46_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS09040	COG2200	EAL domain
E5Z46_RS09055	COG0517	IMP dehydrogenase activity
E5Z46_RS09060	COG2171	N-acyltransferase activity
E5Z46_RS09065	COG1473	amidohydrolase
E5Z46_RS09075	COG0569	domain protein
E5Z46_RS09080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5Z46_RS09085	COG5503	Protein of unknown function (DUF1447)
E5Z46_RS09090	COG0561	phosphatase activity
E5Z46_RS09135	COG1982	Orn Lys Arg decarboxylase major
E5Z46_RS09145	COG4476	Belongs to the UPF0223 family
E5Z46_RS09155	COG0483	inositol monophosphate 1-phosphatase activity
E5Z46_RS09160	COG1217	gtp-binding protein TYPA
E5Z46_RS09175	COG4896	Protein conserved in bacteria
E5Z46_RS09185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5Z46_RS09190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5Z46_RS09195	COG4838	Belongs to the UPF0358 family
E5Z46_RS09200	COG0772	Belongs to the SEDS family
E5Z46_RS09205	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5Z46_RS09210	COG1612	heme a metabolic process
E5Z46_RS09215	COG0109	protoheme IX farnesyltransferase activity
E5Z46_RS09240	COG3336	cytochrome c oxidase
E5Z46_RS09260	COG2340	Cysteine-rich secretory protein family
E5Z46_RS09280	COG3679	Belongs to the UPF0342 family
E5Z46_RS09285	COG4471	UPF0298 protein
E5Z46_RS09295	COG0742	ribosomal rna small subunit methyltransferase
E5Z46_RS09300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5Z46_RS09305	COG3314	Sporulation integral membrane protein YlbJ
E5Z46_RS09310	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Z46_RS09315	COG3480	Lon protease (S16) C-terminal proteolytic domain
E5Z46_RS09320	COG1323	Belongs to the UPF0348 family
E5Z46_RS09325	COG1399	metal-binding, possibly nucleic acid-binding protein
E5Z46_RS09330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5Z46_RS09335	COG1024	Enoyl-CoA hydratase
E5Z46_RS09345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5Z46_RS09355	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
E5Z46_RS09360	COG0275	rRNA processing
E5Z46_RS09365	COG4839	cell division protein FtsL
E5Z46_RS09370	COG0768	penicillin binding
E5Z46_RS09375	COG0768	penicillin binding
E5Z46_RS09380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5Z46_RS09390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5Z46_RS09395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5Z46_RS09400	COG0772	Belongs to the SEDS family
E5Z46_RS09410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5Z46_RS09415	COG3879	Bacterial protein of unknown function (DUF881)
E5Z46_RS09420	COG3879	Bacterial protein of unknown function (DUF881)
E5Z46_RS09425	COG3856	small basic protein
E5Z46_RS09430	COG0849	cell division
E5Z46_RS09435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5Z46_RS09445	COG1191	sigma factor activity
E5Z46_RS09450	COG1191	sigma factor activity
E5Z46_RS09455	COG1873	PFAM PRC-barrel domain
E5Z46_RS09465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5Z46_RS09470	COG1799	cell septum assembly
E5Z46_RS09475	COG0762	integral membrane protein
E5Z46_RS09480	COG2302	S4 RNA-binding domain
E5Z46_RS09485	COG3599	regulation of cell shape
E5Z46_RS09490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5Z46_RS09515	COG1131	(ABC) transporter
E5Z46_RS09525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5Z46_RS09530	COG0564	pseudouridine synthase activity
E5Z46_RS09550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5Z46_RS09615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5Z46_RS09620	COG1561	YicC-like family, N-terminal region
E5Z46_RS09625	COG2052	Domain of unknown function (DUF370)
E5Z46_RS09630	COG0194	GDP metabolic process
E5Z46_RS09635	COG1758	RNA polymerase activity
E5Z46_RS09640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Z46_RS09645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5Z46_RS09660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5Z46_RS09665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5Z46_RS09665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Z46_RS09675	COG0631	protein serine/threonine phosphatase activity
E5Z46_RS09680	COG0515	serine threonine protein kinase
E5Z46_RS09680	COG2815	serine threonine protein kinase
E5Z46_RS09685	COG1162	GTPase activity
E5Z46_RS09690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5Z46_RS09695	COG1564	THIamine pyrophosphokinase
E5Z46_RS09705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5Z46_RS09710	COG1302	Protein conserved in bacteria
E5Z46_RS09715	COG1461	Dihydroxyacetone kinase
E5Z46_RS09720	COG1760	l-serine dehydratase
E5Z46_RS09725	COG1760	l-serine dehydratase
E5Z46_RS09730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5Z46_RS09735	COG2050	protein possibly involved in aromatic compounds catabolism
E5Z46_RS09735	COG1349	DNA-binding transcription factor activity
E5Z46_RS09740	COG0416	fatty acid biosynthetic process
E5Z46_RS09745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5Z46_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS09755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Z46_RS09760	COG0571	ribonuclease III activity
E5Z46_RS09770	COG1196	nuclear chromosome segregation
E5Z46_RS09775	COG0552	protein localization to endoplasmic reticulum
E5Z46_RS09780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E5Z46_RS09785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5Z46_RS09790	COG0228	four-way junction DNA binding
E5Z46_RS09795	COG1837	Belongs to the UPF0109 family
E5Z46_RS09805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5Z46_RS09810	COG0336	Belongs to the RNA methyltransferase TrmD family
E5Z46_RS09825	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5Z46_RS09830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Z46_RS09840	COG2257	FlhB HrpN YscU SpaS Family
E5Z46_RS09845	COG0045	succinate-CoA ligase (ADP-forming) activity
E5Z46_RS09850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5Z46_RS09855	COG0758	DNA mediated transformation
E5Z46_RS09860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Z46_RS09865	COG4974	Belongs to the 'phage' integrase family
E5Z46_RS09870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5Z46_RS09875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5Z46_RS09880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E5Z46_RS09885	COG1815	bacterial-type flagellum-dependent cell motility
E5Z46_RS09890	COG1558	bacterial-type flagellum-dependent cell motility
E5Z46_RS09895	COG1677	Flagellar hook-basal body complex protein FliE
E5Z46_RS09900	COG1766	The M ring may be actively involved in energy transduction
E5Z46_RS09905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5Z46_RS09910	COG1317	bacterial-type flagellum organization
E5Z46_RS09915	COG1157	protein secretion by the type III secretion system
E5Z46_RS09920	COG2882	bacterial-type flagellum organization
E5Z46_RS09930	COG3144	bacterial-type flagellum assembly
E5Z46_RS09935	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E5Z46_RS09940	COG4786	Flagellar basal body rod
E5Z46_RS09945	COG1582	Flagellar protein (FlbD)
E5Z46_RS09955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5Z46_RS09960	COG1776	CheC inhibitor of MCP methylation
E5Z46_RS09960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5Z46_RS09965	COG2201	protein-glutamate methylesterase activity
E5Z46_RS09975	COG1338	Plays a role in the flagellum-specific transport system
E5Z46_RS09980	COG1987	bacterial-type flagellum assembly
E5Z46_RS09985	COG1684	flagellar biosynthetic protein fliR
E5Z46_RS09990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5Z46_RS09995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5Z46_RS10000	COG1419	protein localization to endoplasmic reticulum
E5Z46_RS10005	COG0455	bacterial-type flagellum organization
E5Z46_RS10015	COG0643	Histidine kinase
E5Z46_RS10015	COG2198	Histidine kinase
E5Z46_RS10020	COG0835	chemotaxis
E5Z46_RS10025	COG1776	CheC inhibitor of MCP methylation
E5Z46_RS10030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5Z46_RS10035	COG1191	sigma factor activity
E5Z46_RS10050	COG0052	Belongs to the universal ribosomal protein uS2 family
E5Z46_RS10055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5Z46_RS10060	COG0528	UMP kinase activity
E5Z46_RS10065	COG0233	cytoplasmic translational termination
E5Z46_RS10070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5Z46_RS10075	COG4589	Belongs to the CDS family
E5Z46_RS10080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5Z46_RS10085	COG0750	zinc metalloprotease
E5Z46_RS10090	COG0442	prolyl-tRNA aminoacylation
E5Z46_RS10095	COG2176	DNA-directed DNA polymerase activity
E5Z46_RS10100	COG0779	Required for maturation of 30S ribosomal subunits
E5Z46_RS10105	COG0195	Participates in both transcription termination and antitermination
E5Z46_RS10110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5Z46_RS10115	COG1358	cellular component organization or biogenesis
E5Z46_RS10125	COG1550	Protein conserved in bacteria
E5Z46_RS10130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5Z46_RS10135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5Z46_RS10140	COG0196	riboflavin kinase activity
E5Z46_RS10145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5Z46_RS10150	COG1185	polyribonucleotide nucleotidyltransferase activity
E5Z46_RS10155	COG0726	polysaccharide deacetylase
E5Z46_RS10160	COG0612	Peptidase, M16
E5Z46_RS10165	COG1873	PFAM PRC-barrel domain
E5Z46_RS10170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5Z46_RS10175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Z46_RS10180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5Z46_RS10185	COG0527	aspartate kinase activity
E5Z46_RS10195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5Z46_RS10200	COG0740	serine-type endopeptidase activity
E5Z46_RS10215	COG1674	ftsk spoiiie
E5Z46_RS10215	COG4980	gas vesicle protein
E5Z46_RS10220	COG2188	Transcriptional regulator
E5Z46_RS10225	COG1744	ABC transporter substrate-binding protein PnrA-like
E5Z46_RS10230	COG3845	ABC transporter
E5Z46_RS10235	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS10240	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS10245	COG0612	Peptidase, M16
E5Z46_RS10250	COG0612	Peptidase, M16
E5Z46_RS10255	COG0300	oxidoreductase activity
E5Z46_RS10270	COG1426	Protein conserved in bacteria
E5Z46_RS10275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Z46_RS10280	COG1546	Belongs to the CinA family
E5Z46_RS10280	COG1058	Belongs to the CinA family
E5Z46_RS10295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5Z46_RS10300	COG1418	mRNA catabolic process
E5Z46_RS10305	COG1692	metallophosphoesterase
E5Z46_RS10310	COG2359	stage V sporulation protein S
E5Z46_RS10320	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5Z46_RS10320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5Z46_RS10325	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5Z46_RS10330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5Z46_RS10335	COG4550	Control of competence regulator ComK, YlbF/YmcA
E5Z46_RS10355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5Z46_RS10370	COG3344	reverse transcriptase
E5Z46_RS10385	COG0477	Major facilitator Superfamily
E5Z46_RS10390	COG0840	transmembrane signaling receptor activity
E5Z46_RS10395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5Z46_RS10400	COG1923	regulation of RNA biosynthetic process
E5Z46_RS10405	COG0464	growth
E5Z46_RS10415	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS10420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5Z46_RS10425	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS10430	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Z46_RS10435	COG0183	Belongs to the thiolase family
E5Z46_RS10445	COG0697	spore germination
E5Z46_RS10450	COG2860	membrane
E5Z46_RS10455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5Z46_RS10460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E5Z46_RS10465	COG0789	Transcriptional regulator
E5Z46_RS10470	COG0174	glutamine synthetase
E5Z46_RS10475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5Z46_RS10480	COG1388	LysM domain
E5Z46_RS10485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Z46_RS10490	COG4224	UPF0291 protein
E5Z46_RS10505	COG3763	UPF0154 protein
E5Z46_RS10510	COG1132	(ABC) transporter
E5Z46_RS10515	COG1132	(ABC) transporter
E5Z46_RS10525	COG0785	Cytochrome C biogenesis protein
E5Z46_RS10530	COG2201	protein-glutamate methylesterase activity
E5Z46_RS10535	COG4846	Membrane protein involved in cytochrome C biogenesis
E5Z46_RS10545	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5Z46_RS10545	COG1388	LysM domain
E5Z46_RS10575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5Z46_RS10590	COG0328	RNA-DNA hybrid ribonuclease activity
E5Z46_RS10610	COG3344	reverse transcriptase
E5Z46_RS10630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5Z46_RS10640	COG5001	Diguanylate cyclase
E5Z46_RS10650	COG0346	lactoylglutathione lyase activity
E5Z46_RS10665	COG0010	Belongs to the arginase family
E5Z46_RS10670	COG1917	Cupin 2, conserved barrel domain protein
E5Z46_RS10670	COG4977	sequence-specific DNA binding
E5Z46_RS10675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5Z46_RS10680	COG1228	amidohydrolase
E5Z46_RS10695	COG3344	reverse transcriptase
E5Z46_RS10700	COG1970	mechanosensitive ion channel activity
E5Z46_RS10705	COG2391	methyltransferase activity
E5Z46_RS10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Z46_RS10715	COG2313	pseudouridylate synthase activity
E5Z46_RS10725	COG0653	protein targeting
E5Z46_RS10730	COG3384	dioxygenase
E5Z46_RS10860	COG0154	amidase activity
E5Z46_RS10875	COG0579	oxidoreductase
E5Z46_RS10880	COG5582	Belongs to the UPF0302 family
E5Z46_RS10885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Z46_RS10890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E5Z46_RS10895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS10910	COG1595	DNA-templated transcription, initiation
E5Z46_RS10920	COG0393	Putative heavy-metal-binding
E5Z46_RS10925	COG0640	Transcriptional regulator
E5Z46_RS10935	COG0583	DNA-binding transcription factor activity
E5Z46_RS10940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5Z46_RS10945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Z46_RS10970	COG3290	protein histidine kinase activity
E5Z46_RS10970	COG3829	transcription factor binding
E5Z46_RS10975	COG2851	Citrate transporter
E5Z46_RS10990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS10995	COG4605	iron ion homeostasis
E5Z46_RS11000	COG4604	ABC transporter, ATP-binding protein
E5Z46_RS11005	COG4607	ABC-type enterochelin transport system periplasmic component
E5Z46_RS11045	COG0604	alcohol dehydrogenase
E5Z46_RS11050	COG0583	DNA-binding transcription factor activity
E5Z46_RS11055	COG0069	glutamate synthase activity
E5Z46_RS11055	COG0067	glutamate synthase
E5Z46_RS11055	COG0070	glutamate synthase
E5Z46_RS11060	COG0493	'glutamate synthase
E5Z46_RS11065	COG0671	phosphoesterase, PA-phosphatase related
E5Z46_RS11085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5Z46_RS11095	COG0697	spore germination
E5Z46_RS11105	COG4821	SIS domain
E5Z46_RS11115	COG2340	Cysteine-rich secretory protein family
E5Z46_RS11160	COG0004	ammonium transporteR
E5Z46_RS11180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5Z46_RS11190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS11200	COG1120	ATPase activity
E5Z46_RS11230	COG0406	alpha-ribazole phosphatase activity
E5Z46_RS11235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z46_RS11240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z46_RS11250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Z46_RS11260	COG4555	ABC transporter
E5Z46_RS11280	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS11285	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS11295	COG2135	peptidase activity
E5Z46_RS11315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Z46_RS11315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5Z46_RS11320	COG0456	acetyltransferase
E5Z46_RS11325	COG1414	Transcriptional regulator
E5Z46_RS11330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5Z46_RS11335	COG1984	allophanate hydrolase subunit 2
E5Z46_RS11340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5Z46_RS11355	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS11370	COG3344	reverse transcriptase
E5Z46_RS11380	COG0463	Glycosyl transferase, family 2
E5Z46_RS11385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5Z46_RS11390	COG0351	phosphomethylpyrimidine kinase
E5Z46_RS11395	COG0352	thiamine-phosphate diphosphorylase activity
E5Z46_RS11400	COG3594	Acyltransferase
E5Z46_RS11415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5Z46_RS11420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Z46_RS11440	COG5002	protein histidine kinase activity
E5Z46_RS11450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Z46_RS11470	COG0670	Belongs to the BI1 family
E5Z46_RS11475	COG3622	Belongs to the hyi family
E5Z46_RS11485	COG0277	FAD linked oxidase domain protein
E5Z46_RS11490	COG0247	lactate metabolic process
E5Z46_RS11495	COG0277	FAD linked oxidase domain protein
E5Z46_RS11500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5Z46_RS11505	COG0281	malic enzyme
E5Z46_RS11510	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5Z46_RS11515	COG1414	Transcriptional regulator
E5Z46_RS11520	COG1205	dead DEAH box helicase
E5Z46_RS11520	COG1111	helicase
E5Z46_RS11545	COG3599	regulation of cell shape
E5Z46_RS11555	COG0116	Belongs to the methyltransferase superfamily
E5Z46_RS11560	COG1199	ATP-dependent helicase activity
E5Z46_RS11565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E5Z46_RS11570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5Z46_RS11575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5Z46_RS11585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Z46_RS11590	COG2233	PERMEase
E5Z46_RS11600	COG3424	synthase
E5Z46_RS11605	COG1755	Isoprenylcysteine carboxyl methyltransferase
E5Z46_RS11610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Z46_RS11625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS11645	COG0824	Thioesterase
E5Z46_RS11655	COG2050	protein possibly involved in aromatic compounds catabolism
E5Z46_RS11660	COG4841	protein insertion into membrane
E5Z46_RS11680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5Z46_RS11685	COG4479	Belongs to the UPF0346 family
E5Z46_RS11715	COG0813	purine-nucleoside phosphorylase activity
E5Z46_RS11720	COG1876	peptidase activity
E5Z46_RS11725	COG2226	methyltransferase
E5Z46_RS11730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5Z46_RS11735	COG0598	Magnesium transport protein CorA
E5Z46_RS11745	COG2962	Rard protein
E5Z46_RS11765	COG0534	Mate efflux family protein
E5Z46_RS11780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Z46_RS11805	COG1309	transcriptional regulator
E5Z46_RS11810	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS11820	COG0439	Biotin carboxylase
E5Z46_RS11825	COG0511	ligase activity, forming carbon-carbon bonds
E5Z46_RS11830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Z46_RS11835	COG1024	Enoyl-CoA hydratase
E5Z46_RS11840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5Z46_RS11850	COG1846	Transcriptional regulator
E5Z46_RS11855	COG1566	PFAM secretion protein HlyD family protein
E5Z46_RS11860	COG2814	Major facilitator Superfamily
E5Z46_RS11865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Z46_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS11895	COG2205	protein histidine kinase activity
E5Z46_RS11925	COG1725	Transcriptional regulator
E5Z46_RS11930	COG1131	(ABC) transporter
E5Z46_RS11945	COG0697	spore germination
E5Z46_RS11960	COG2208	phosphoserine phosphatase activity
E5Z46_RS11965	COG3290	protein histidine kinase activity
E5Z46_RS11975	COG1132	(ABC) transporter
E5Z46_RS11980	COG1132	(ABC) transporter
E5Z46_RS11985	COG2258	MOSC domain
E5Z46_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5Z46_RS12015	COG0730	response to heat
E5Z46_RS12020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS12035	COG1131	(ABC) transporter
E5Z46_RS12040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E5Z46_RS12085	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5Z46_RS12095	COG1741	Belongs to the pirin family
E5Z46_RS12100	COG0778	Nitroreductase
E5Z46_RS12105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5Z46_RS12110	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS12125	COG2030	dehydratase
E5Z46_RS12135	COG0183	Belongs to the thiolase family
E5Z46_RS12145	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS12160	COG3344	reverse transcriptase
E5Z46_RS12185	COG0697	spore germination
E5Z46_RS12200	COG1612	heme a metabolic process
E5Z46_RS12210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5Z46_RS12235	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E5Z46_RS12240	COG1119	ATPase activity
E5Z46_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS12295	COG1024	Enoyl-CoA hydratase
E5Z46_RS12300	COG0515	serine threonine protein kinase
E5Z46_RS12310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Z46_RS12310	COG0551	DNA topoisomerase type I activity
E5Z46_RS12315	COG5002	protein histidine kinase activity
E5Z46_RS12320	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS12330	COG1388	LysM domain
E5Z46_RS12340	COG1113	amino acid transport
E5Z46_RS12345	COG3402	PFAM membrane-flanked domain
E5Z46_RS12355	COG1279	arginine transmembrane transporter activity
E5Z46_RS12425	COG2404	hydrolase activity, acting on ester bonds
E5Z46_RS12430	COG4548	von Willebrand factor, type A
E5Z46_RS12445	COG0788	formyltetrahydrofolate deformylase activity
E5Z46_RS12450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Z46_RS12450	COG1017	nitric oxide dioxygenase activity
E5Z46_RS12455	COG1959	2 iron, 2 sulfur cluster binding
E5Z46_RS12465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5Z46_RS12470	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS12475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5Z46_RS12475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5Z46_RS12485	COG1757	Na H antiporter
E5Z46_RS12490	COG2188	Transcriptional regulator
E5Z46_RS12495	COG0366	Alpha amylase catalytic
E5Z46_RS12500	COG1263	PTS System
E5Z46_RS12500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Z46_RS12520	COG0187	DNA topoisomerase II activity
E5Z46_RS12525	COG1832	CoA-binding protein
E5Z46_RS12540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5Z46_RS12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS12595	COG3647	Membrane
E5Z46_RS12610	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5Z46_RS12615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5Z46_RS12620	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5Z46_RS12645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5Z46_RS12650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Z46_RS12650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5Z46_RS12655	COG3344	reverse transcriptase
E5Z46_RS12670	COG2755	lipolytic protein G-D-S-L family
E5Z46_RS12675	COG1999	signal sequence binding
E5Z46_RS12695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Z46_RS12705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5Z46_RS12710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5Z46_RS12725	COG0436	Aminotransferase
E5Z46_RS12740	COG0494	nUDIX hydrolase
E5Z46_RS12755	COG1413	lyase activity
E5Z46_RS12760	COG0386	Belongs to the glutathione peroxidase family
E5Z46_RS12780	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E5Z46_RS12785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5Z46_RS12790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5Z46_RS12800	COG1492	cobalamin metabolic process
E5Z46_RS12860	COG1122	ATPase activity
E5Z46_RS12865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5Z46_RS12870	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
E5Z46_RS12875	COG0310	cobalt ion transport
E5Z46_RS12910	COG0584	glycerophosphoryl diester phosphodiesterase
E5Z46_RS12920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Z46_RS12925	COG4989	oxidoreductase activity
E5Z46_RS12930	COG1164	Oligoendopeptidase f
E5Z46_RS12935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5Z46_RS12940	COG1335	isochorismatase
E5Z46_RS12945	COG0706	membrane insertase activity
E5Z46_RS12970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E5Z46_RS12975	COG1140	nitrate reductase beta subunit
E5Z46_RS12980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E5Z46_RS12985	COG2181	nitrate reductase activity
E5Z46_RS12990	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E5Z46_RS13000	COG1587	Uroporphyrinogen-III synthase
E5Z46_RS13020	COG5002	protein histidine kinase activity
E5Z46_RS13025	COG0024	Methionine aminopeptidase
E5Z46_RS13030	COG0432	Pfam Uncharacterised protein family UPF0047
E5Z46_RS13040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Z46_RS13040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Z46_RS13040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Z46_RS13045	COG1105	Belongs to the carbohydrate kinase PfkB family
E5Z46_RS13050	COG1349	DNA-binding transcription factor activity
E5Z46_RS13060	COG1131	(ABC) transporter
E5Z46_RS13100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5Z46_RS13100	COG2199	diguanylate cyclase activity
E5Z46_RS13125	COG2188	Transcriptional regulator
E5Z46_RS13140	COG2182	Extracellular solute-binding protein
E5Z46_RS13145	COG0395	ABC-type sugar transport system, permease component
E5Z46_RS13150	COG1175	transmembrane transport
E5Z46_RS13155	COG3335	DDE superfamily endonuclease
E5Z46_RS13165	COG1940	carbohydrate kinase activity
E5Z46_RS13180	COG3458	cephalosporin-C deacetylase activity
E5Z46_RS13235	COG0385	Bile acid
E5Z46_RS13245	COG1757	Na H antiporter
E5Z46_RS13250	COG1408	metallophosphoesterase
E5Z46_RS13255	COG0726	polysaccharide deacetylase
E5Z46_RS13265	COG2188	Transcriptional regulator
E5Z46_RS13270	COG2723	6-phospho-beta-galactosidase activity
E5Z46_RS13275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Z46_RS13280	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5Z46_RS13285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Z46_RS13290	COG0789	Transcriptional regulator
E5Z46_RS13300	COG1846	Transcriptional regulator
E5Z46_RS13305	COG2223	nitrite transmembrane transporter activity
E5Z46_RS13310	COG0243	molybdopterin cofactor binding
E5Z46_RS13315	COG2146	nitrite reductase [NAD(P)H] activity
E5Z46_RS13320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Z46_RS13325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5Z46_RS13345	COG3290	protein histidine kinase activity
E5Z46_RS13345	COG3829	transcription factor binding
E5Z46_RS13360	COG1070	Carbohydrate kinase
E5Z46_RS13365	COG2115	Belongs to the xylose isomerase family
E5Z46_RS13380	COG4214	carbohydrate transport
E5Z46_RS13385	COG1129	ABC transporter
E5Z46_RS13390	COG4213	ABC transporter substrate-binding protein
E5Z46_RS13405	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS13410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Z46_RS13415	COG3718	enzyme involved in inositol metabolism
E5Z46_RS13420	COG1082	Xylose isomerase domain protein TIM barrel
E5Z46_RS13425	COG3962	Belongs to the TPP enzyme family
E5Z46_RS13430	COG1082	Xylose isomerase domain protein TIM barrel
E5Z46_RS13435	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS13440	COG1129	ABC transporter
E5Z46_RS13450	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS13460	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS13465	COG1609	Transcriptional regulator
E5Z46_RS13470	COG1024	Enoyl-CoA hydratase
E5Z46_RS13475	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS13480	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E5Z46_RS13485	COG0110	maltose O-acetyltransferase activity
E5Z46_RS13505	COG0456	acetyltransferase
E5Z46_RS13525	COG0830	nickel cation binding
E5Z46_RS13530	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E5Z46_RS13535	COG0804	urea catabolic process
E5Z46_RS13540	COG0832	Belongs to the urease beta subunit family
E5Z46_RS13545	COG0831	urea catabolic process
E5Z46_RS13555	COG0411	ABC transporter
E5Z46_RS13575	COG0840	transmembrane signaling receptor activity
E5Z46_RS13585	COG1070	Carbohydrate kinase
E5Z46_RS13590	COG1609	Transcriptional regulator
E5Z46_RS13595	COG0679	Auxin Efflux Carrier
E5Z46_RS13600	COG4565	transcriptional regulatory protein
E5Z46_RS13605	COG3290	protein histidine kinase activity
E5Z46_RS13635	COG0246	Mannitol dehydrogenase
E5Z46_RS13645	COG3711	transcriptional antiterminator
E5Z46_RS13670	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS13685	COG0667	Aldo Keto reductase
E5Z46_RS13700	COG0765	amino acid transport
E5Z46_RS13705	COG0765	amino acid transport
E5Z46_RS13710	COG4191	Histidine kinase
E5Z46_RS13715	COG0784	Response regulator, receiver
E5Z46_RS13720	COG1737	Transcriptional regulator
E5Z46_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS13755	COG2755	lipolytic protein G-D-S-L family
E5Z46_RS13760	COG0385	Bile acid
E5Z46_RS13780	COG3764	Sortase (surface protein transpeptidase)
E5Z46_RS13815	COG1175	transmembrane transport
E5Z46_RS13820	COG3842	ATPase activity
E5Z46_RS13845	COG0022	dehydrogenase e1 component
E5Z46_RS13855	COG3842	ATPase activity
E5Z46_RS13860	COG4120	Belongs to the binding-protein-dependent transport system permease family
E5Z46_RS13885	COG3327	negative regulation of DNA-templated transcription, initiation
E5Z46_RS13890	COG0183	Belongs to the thiolase family
E5Z46_RS13895	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Z46_RS13900	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS13905	COG1024	Enoyl-CoA hydratase
E5Z46_RS13910	COG1024	Enoyl-CoA hydratase
E5Z46_RS13920	COG2151	metal-sulfur cluster biosynthetic enzyme
E5Z46_RS13935	COG3396	Phenylacetate-CoA oxygenase
E5Z46_RS13940	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5Z46_RS13945	COG0129	dihydroxy-acid dehydratase activity
E5Z46_RS13950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5Z46_RS13955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5Z46_RS13965	COG2246	polysaccharide biosynthetic process
E5Z46_RS13970	COG0463	Glycosyl transferase, family 2
E5Z46_RS13985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5Z46_RS13990	COG1609	Transcriptional regulator
E5Z46_RS13995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5Z46_RS14000	COG0710	3-dehydroquinate dehydratase activity
E5Z46_RS14005	COG1414	Transcriptional regulator
E5Z46_RS14010	COG2271	Major facilitator Superfamily
E5Z46_RS14015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5Z46_RS14020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5Z46_RS14025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5Z46_RS14035	COG0028	Belongs to the TPP enzyme family
E5Z46_RS14045	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS14055	COG3344	reverse transcriptase
E5Z46_RS14075	COG0561	phosphatase activity
E5Z46_RS14100	COG0730	response to heat
E5Z46_RS14105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS14105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS14110	COG0425	Belongs to the sulfur carrier protein TusA family
E5Z46_RS14110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS14115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS14115	COG0425	Belongs to the sulfur carrier protein TusA family
E5Z46_RS14125	COG2210	Belongs to the sulfur carrier protein TusA family
E5Z46_RS14130	COG0425	Belongs to the sulfur carrier protein TusA family
E5Z46_RS14135	COG1937	Protein conserved in bacteria
E5Z46_RS14145	COG2226	methyltransferase
E5Z46_RS14170	COG1664	Polymer-forming cytoskeletal
E5Z46_RS14175	COG0789	Transcriptional regulator
E5Z46_RS14180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5Z46_RS14185	COG0457	Tetratricopeptide repeat
E5Z46_RS14185	COG0463	Glycosyl transferase, family 2
E5Z46_RS14205	COG4336	lyase activity
E5Z46_RS14215	COG1061	Type III restriction enzyme res subunit
E5Z46_RS14240	COG1082	Xylose isomerase domain protein TIM barrel
E5Z46_RS14245	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS14255	COG0673	inositol 2-dehydrogenase activity
E5Z46_RS14260	COG1609	Transcriptional regulator
E5Z46_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS14275	COG2030	dehydratase
E5Z46_RS14290	COG1653	transport
E5Z46_RS14300	COG2066	Belongs to the glutaminase family
E5Z46_RS14325	COG0156	8-amino-7-oxononanoate synthase activity
E5Z46_RS14340	COG4377	Putative membrane peptidase family (DUF2324)
E5Z46_RS14350	COG0640	Transcriptional regulator
E5Z46_RS14360	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS14370	COG2368	4-hydroxyphenylacetate
E5Z46_RS14375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Z46_RS14460	COG0071	Belongs to the small heat shock protein (HSP20) family
E5Z46_RS14465	COG1609	Transcriptional regulator
E5Z46_RS14470	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5Z46_RS14475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Z46_RS14480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5Z46_RS14485	COG3250	beta-galactosidase activity
E5Z46_RS14510	COG2217	Heavy metal translocating P-type atpase
E5Z46_RS14520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5Z46_RS14525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E5Z46_RS14530	COG5002	protein histidine kinase activity
E5Z46_RS14535	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS14555	COG3344	reverse transcriptase
E5Z46_RS14585	COG3331	DNA recombination
E5Z46_RS14590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Z46_RS14590	COG4499	WXG100 protein secretion system (Wss), protein YukC
E5Z46_RS14595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5Z46_RS14600	COG3935	DnaD domain protein
E5Z46_RS14605	COG0017	Asparaginyl-tRNA synthetase
E5Z46_RS14630	COG1199	ATP-dependent helicase activity
E5Z46_RS14630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5Z46_RS14635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5Z46_RS14640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5Z46_RS14645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5Z46_RS14660	COG0438	transferase activity, transferring glycosyl groups
E5Z46_RS14665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5Z46_RS14670	COG1803	Methylglyoxal synthase
E5Z46_RS14680	COG1694	Mazg nucleotide pyrophosphohydrolase
E5Z46_RS14685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Z46_RS14695	COG4347	Protein of unknown function (DUF1405)
E5Z46_RS14720	COG5582	Belongs to the UPF0302 family
E5Z46_RS14725	COG0457	Tetratricopeptide repeat
E5Z46_RS14730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5Z46_RS14735	COG0287	Prephenate dehydrogenase
E5Z46_RS14740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5Z46_RS14745	COG0159	tryptophan synthase activity
E5Z46_RS14755	COG0135	phosphoribosylanthranilate isomerase activity
E5Z46_RS14760	COG0134	indole-3-glycerol-phosphate synthase activity
E5Z46_RS14765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5Z46_RS14775	COG4401	Chorismate mutase type I
E5Z46_RS14780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5Z46_RS14785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5Z46_RS14790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5Z46_RS14795	COG0105	UTP biosynthetic process
E5Z46_RS14805	COG2226	methyltransferase
E5Z46_RS14820	COG0302	gtp cyclohydrolase
E5Z46_RS14835	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Z46_RS14850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5Z46_RS14855	COG1160	GTP binding
E5Z46_RS14880	COG0539	negative regulation of cytoplasmic translation
E5Z46_RS14885	COG0204	Acyl-transferase
E5Z46_RS14890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5Z46_RS14915	COG2959	enzyme of heme biosynthesis
E5Z46_RS14920	COG3773	Cell wall hydrolase
E5Z46_RS14920	COG3409	Peptidoglycan-binding domain 1 protein
E5Z46_RS14925	COG2339	peptidase activity
E5Z46_RS14935	COG0492	ferredoxin-NADP+ reductase activity
E5Z46_RS14940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Z46_RS14945	COG4862	establishment of competence for transformation
E5Z46_RS14965	COG3546	catalase activity
E5Z46_RS14985	COG0514	ATP-dependent DNA helicase (RecQ)
E5Z46_RS14990	COG4955	Helix-turn-helix domain
E5Z46_RS15005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5Z46_RS15010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5Z46_RS15020	COG1595	DNA-templated transcription, initiation
E5Z46_RS15035	COG2096	Adenosyltransferase
E5Z46_RS15050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5Z46_RS15055	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E5Z46_RS15060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5Z46_RS15065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5Z46_RS15070	COG1120	ATPase activity
E5Z46_RS15075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS15080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5Z46_RS15090	COG0531	amino acid
E5Z46_RS15105	COG3279	Response regulator of the LytR AlgR family
E5Z46_RS15110	COG3275	phosphorelay sensor kinase activity
E5Z46_RS15120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Z46_RS15120	COG1263	PTS System
E5Z46_RS15125	COG2188	Transcriptional regulator
E5Z46_RS15130	COG0363	glucosamine-6-phosphate deaminase activity
E5Z46_RS15135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5Z46_RS15140	COG5002	protein histidine kinase activity
E5Z46_RS15145	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS15150	COG3344	reverse transcriptase
E5Z46_RS15160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5Z46_RS15165	COG1333	cytochrome c biogenesis protein
E5Z46_RS15170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Z46_RS15175	COG1187	pseudouridine synthase activity
E5Z46_RS15180	COG0700	Nucleoside recognition
E5Z46_RS15185	COG2715	membrane protein required for spore maturation
E5Z46_RS15190	COG1686	Belongs to the peptidase S11 family
E5Z46_RS15195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Z46_RS15205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5Z46_RS15210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5Z46_RS15215	COG1547	Domain of unknown function (DUF309)
E5Z46_RS15230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5Z46_RS15240	COG0307	riboflavin synthase, alpha
E5Z46_RS15245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Z46_RS15245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Z46_RS15250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5Z46_RS15255	COG4086	secreted protein
E5Z46_RS15260	COG0019	diaminopimelate decarboxylase activity
E5Z46_RS15265	COG3344	reverse transcriptase
E5Z46_RS15275	COG0697	spore germination
E5Z46_RS15290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5Z46_RS15310	COG1191	sigma factor activity
E5Z46_RS15315	COG2172	sigma factor antagonist activity
E5Z46_RS15325	COG1686	Belongs to the peptidase S11 family
E5Z46_RS15345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5Z46_RS15350	COG4974	Belongs to the 'phage' integrase family
E5Z46_RS15360	COG0735	belongs to the Fur family
E5Z46_RS15365	COG1300	Membrane
E5Z46_RS15370	COG1379	DNA repair
E5Z46_RS15375	COG0494	nUDIX hydrolase
E5Z46_RS15380	COG0667	Aldo Keto reductase
E5Z46_RS15415	COG0300	oxidoreductase activity
E5Z46_RS15420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS15425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5Z46_RS15430	COG1902	pentaerythritol trinitrate reductase activity
E5Z46_RS15435	COG1234	tRNA 3'-trailer cleavage
E5Z46_RS15440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5Z46_RS15445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E5Z46_RS15455	COG2723	6-phospho-beta-galactosidase activity
E5Z46_RS15475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5Z46_RS15485	COG0835	chemotaxis
E5Z46_RS15490	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5Z46_RS15495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5Z46_RS15500	COG0346	lactoylglutathione lyase activity
E5Z46_RS15505	COG1376	ErfK ybiS ycfS ynhG family protein
E5Z46_RS15510	COG4129	membrane
E5Z46_RS15540	COG1131	(ABC) transporter
E5Z46_RS15575	COG1131	(ABC) transporter
E5Z46_RS15610	COG1703	isobutyryl-CoA mutase activity
E5Z46_RS15615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5Z46_RS15615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5Z46_RS15635	COG5002	protein histidine kinase activity
E5Z46_RS15640	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS15650	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5Z46_RS15655	COG0022	dehydrogenase e1 component
E5Z46_RS15660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5Z46_RS15665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Z46_RS15670	COG3426	butyrate kinase activity
E5Z46_RS15680	COG0280	phosphate acetyltransferase
E5Z46_RS15685	COG3290	protein histidine kinase activity
E5Z46_RS15685	COG3829	transcription factor binding
E5Z46_RS15695	COG0584	glycerophosphoryl diester phosphodiesterase
E5Z46_RS15700	COG3093	addiction module antidote protein HigA
E5Z46_RS15710	COG0750	zinc metalloprotease
E5Z46_RS15715	COG0497	DNA recombination
E5Z46_RS15720	COG1438	arginine binding
E5Z46_RS15725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5Z46_RS15730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5Z46_RS15740	COG1722	exodeoxyribonuclease VII activity
E5Z46_RS15745	COG1570	exodeoxyribonuclease VII activity
E5Z46_RS15750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5Z46_RS15755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5Z46_RS15760	COG1302	Protein conserved in bacteria
E5Z46_RS15765	COG0439	Biotin carboxylase
E5Z46_RS15770	COG0511	ligase activity, forming carbon-carbon bonds
E5Z46_RS15810	COG3854	ATPases associated with a variety of cellular activities
E5Z46_RS15820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5Z46_RS15825	COG0006	proline dipeptidase activity
E5Z46_RS15835	COG3872	metal-dependent enzyme
E5Z46_RS15845	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Z46_RS15850	COG1321	iron dependent repressor
E5Z46_RS15870	COG3858	chitin binding
E5Z46_RS15870	COG1388	LysM domain
E5Z46_RS15880	COG0095	Lipoate-protein ligase
E5Z46_RS15885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS15900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5Z46_RS15905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5Z46_RS15910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5Z46_RS15945	COG4537	Required for transformation and DNA binding
E5Z46_RS15950	COG1459	type II secretion system
E5Z46_RS15955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5Z46_RS15975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS15990	COG1940	carbohydrate kinase activity
E5Z46_RS15995	COG4483	Protein conserved in bacteria
E5Z46_RS16000	COG0697	spore germination
E5Z46_RS16010	COG0705	Rhomboid family
E5Z46_RS16010	COG0457	Tetratricopeptide repeat
E5Z46_RS16025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5Z46_RS16045	COG3344	reverse transcriptase
E5Z46_RS16055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Z46_RS16060	COG0768	penicillin binding
E5Z46_RS16065	COG0477	Major facilitator Superfamily
E5Z46_RS16075	COG0840	transmembrane signaling receptor activity
E5Z46_RS16080	COG5521	maltodextrose utilization protein MalA
E5Z46_RS16085	COG0581	inorganic phosphate transmembrane transporter activity
E5Z46_RS16090	COG0573	inorganic phosphate transmembrane transporter activity
E5Z46_RS16095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Z46_RS16100	COG1388	LysM domain
E5Z46_RS16105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5Z46_RS16110	COG4709	membrane
E5Z46_RS16115	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
E5Z46_RS16120	COG0735	belongs to the Fur family
E5Z46_RS16125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5Z46_RS16130	COG1121	(ABC) transporter
E5Z46_RS16135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Z46_RS16145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5Z46_RS16160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5Z46_RS16165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5Z46_RS16170	COG2384	SAM-dependent methyltransferase
E5Z46_RS16175	COG2010	Cytochrome c
E5Z46_RS16185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5Z46_RS16195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5Z46_RS16200	COG0517	IMP dehydrogenase activity
E5Z46_RS16205	COG1381	Involved in DNA repair and RecF pathway recombination
E5Z46_RS16215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Z46_RS16220	COG0295	cytidine deaminase activity
E5Z46_RS16225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5Z46_RS16230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5Z46_RS16235	COG1480	7TM receptor with intracellular HD hydrolase
E5Z46_RS16240	COG1702	phosphate starvation-inducible protein PhoH
E5Z46_RS16255	COG1610	YqeY-like protein
E5Z46_RS16260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5Z46_RS16265	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5Z46_RS16270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5Z46_RS16275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5Z46_RS16280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Z46_RS16285	COG2264	protein methyltransferase activity
E5Z46_RS16290	COG0484	heat shock protein binding
E5Z46_RS16295	COG0443	Heat shock 70 kDa protein
E5Z46_RS16305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5Z46_RS16310	COG1420	regulation of RNA biosynthetic process
E5Z46_RS16315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Z46_RS16335	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5Z46_RS16340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5Z46_RS16345	COG0268	Binds directly to 16S ribosomal RNA
E5Z46_RS16350	COG1466	dna polymerase III delta subunit
E5Z46_RS16365	COG2131	deaminase
E5Z46_RS16370	COG1555	photosystem II stabilization
E5Z46_RS16370	COG1596	polysaccharide export
E5Z46_RS16375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5Z46_RS16380	COG2226	methyltransferase
E5Z46_RS16385	COG0799	negative regulation of ribosome biogenesis
E5Z46_RS16390	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5Z46_RS16395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5Z46_RS16400	COG1534	Rna-binding protein
E5Z46_RS16405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5Z46_RS16410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5Z46_RS16415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E5Z46_RS16425	COG0688	phosphatidylethanolamine metabolic process
E5Z46_RS16430	COG1183	phosphatidylcholine synthase activity
E5Z46_RS16435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5Z46_RS16440	COG1360	Flagellar Motor Protein
E5Z46_RS16450	COG0586	Pfam SNARE associated Golgi protein
E5Z46_RS16455	COG3344	reverse transcriptase
E5Z46_RS16500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Z46_RS16510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5Z46_RS16515	COG2226	methyltransferase
E5Z46_RS16530	COG0768	penicillin binding
E5Z46_RS16535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5Z46_RS16540	COG0572	uridine kinase
E5Z46_RS16545	COG0826	peptidase U32
E5Z46_RS16550	COG0826	peptidase U32
E5Z46_RS16555	COG4122	O-methyltransferase activity
E5Z46_RS16565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5Z46_RS16570	COG3906	Belongs to the UPF0473 family
E5Z46_RS16575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5Z46_RS16585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5Z46_RS16590	COG0628	permease
E5Z46_RS16610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Z46_RS16620	COG0482	sulfurtransferase activity
E5Z46_RS16625	COG1104	cysteine desulfurase activity
E5Z46_RS16630	COG1959	2 iron, 2 sulfur cluster binding
E5Z46_RS16635	COG2364	Membrane
E5Z46_RS16640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Z46_RS16645	COG1309	transcriptional regulator
E5Z46_RS16650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5Z46_RS16660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5Z46_RS16670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5Z46_RS16675	COG0124	histidyl-tRNA synthetase
E5Z46_RS16680	COG3634	alkyl hydroperoxide reductase activity
E5Z46_RS16685	COG0450	alkyl hydroperoxide reductase
E5Z46_RS16690	COG1490	D-aminoacyl-tRNA deacylase activity
E5Z46_RS16700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Z46_RS16705	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5Z46_RS16705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Z46_RS16710	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5Z46_RS16715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Z46_RS16715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Z46_RS16725	COG2244	polysaccharide biosynthetic process
E5Z46_RS16735	COG1862	Preprotein translocase
E5Z46_RS16740	COG0343	queuine tRNA-ribosyltransferase activity
E5Z46_RS16745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5Z46_RS16755	COG2255	four-way junction helicase activity
E5Z46_RS16760	COG0632	four-way junction helicase activity
E5Z46_RS16770	COG0217	transcriptional regulatory protein
E5Z46_RS16780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5Z46_RS16790	COG1388	LysM domain
E5Z46_RS16795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5Z46_RS16800	COG0157	Belongs to the NadC ModD family
E5Z46_RS16805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5Z46_RS16810	COG1104	cysteine desulfurase activity
E5Z46_RS16815	COG1827	regulation of RNA biosynthetic process
E5Z46_RS16820	COG0077	Prephenate dehydratase
E5Z46_RS16825	COG4492	Belongs to the UPF0735 family
E5Z46_RS16830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5Z46_RS16835	COG3290	protein histidine kinase activity
E5Z46_RS16840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5Z46_RS16845	COG2868	ribosomal protein
E5Z46_RS16850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5Z46_RS16855	COG1994	Peptidase M50
E5Z46_RS16860	COG0739	heme binding
E5Z46_RS16870	COG2894	cell division
E5Z46_RS16875	COG0850	regulation of cytokinetic process
E5Z46_RS16885	COG1792	Involved in formation and maintenance of cell shape
E5Z46_RS16890	COG1077	Cell shape determining protein MreB Mrl
E5Z46_RS16895	COG2003	Belongs to the UPF0758 family
E5Z46_RS16900	COG0424	maF-like protein
E5Z46_RS16930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5Z46_RS16940	COG1459	type II secretion system
E5Z46_RS16950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5Z46_RS16985	COG3344	reverse transcriptase
E5Z46_RS17000	COG0285	dihydrofolate synthase activity
E5Z46_RS17005	COG0525	valine-tRNA ligase activity
E5Z46_RS17020	COG1388	LysM domain
E5Z46_RS17020	COG1388	LysM domain
E5Z46_RS17025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5Z46_RS17030	COG0113	porphobilinogen synthase activity
E5Z46_RS17040	COG0181	hydroxymethylbilane synthase activity
E5Z46_RS17045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5Z46_RS17050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5Z46_RS17060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5Z46_RS17065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5Z46_RS17070	COG1067	ATP-dependent peptidase activity
E5Z46_RS17070	COG0470	DNA polymerase III
E5Z46_RS17075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5Z46_RS17080	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5Z46_RS17090	COG0066	3-isopropylmalate dehydratase activity
E5Z46_RS17095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5Z46_RS17100	COG0473	3-isopropylmalate dehydrogenase activity
E5Z46_RS17105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Z46_RS17110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5Z46_RS17115	COG0440	acetolactate synthase activity
E5Z46_RS17120	COG0028	Belongs to the TPP enzyme family
E5Z46_RS17130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5Z46_RS17135	COG0622	Phosphoesterase
E5Z46_RS17140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5Z46_RS17145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5Z46_RS17150	COG5401	PFAM Sporulation and spore germination
E5Z46_RS17155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5Z46_RS17160	COG1846	Transcriptional regulator
E5Z46_RS17165	COG3344	reverse transcriptase
E5Z46_RS17175	COG2197	response regulator
E5Z46_RS17180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5Z46_RS17185	COG1053	succinate dehydrogenase
E5Z46_RS17190	COG2009	succinate dehydrogenase
E5Z46_RS17195	COG1719	4-vinyl reductase, 4VR
E5Z46_RS17200	COG0322	excinuclease ABC activity
E5Z46_RS17220	COG0463	Glycosyl transferase, family 2
E5Z46_RS17235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5Z46_RS17250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5Z46_RS17255	COG0431	NADPH-dependent FMN reductase
E5Z46_RS17260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5Z46_RS17265	COG1116	anion transmembrane transporter activity
E5Z46_RS17270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5Z46_RS17275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5Z46_RS17280	COG3118	belongs to the thioredoxin family
E5Z46_RS17285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5Z46_RS17290	COG2086	electron transfer activity
E5Z46_RS17295	COG1024	Enoyl-CoA hydratase
E5Z46_RS17300	COG1309	transcriptional regulator
E5Z46_RS17305	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS17310	COG3766	membrane
E5Z46_RS17315	COG1193	negative regulation of DNA recombination
E5Z46_RS17320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5Z46_RS17320	COG1796	DNA polymerase
E5Z46_RS17325	COG1286	toxin biosynthetic process
E5Z46_RS17330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E5Z46_RS17335	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Z46_RS17345	COG2409	Drug exporters of the RND superfamily
E5Z46_RS17345	COG1033	growth of symbiont in host cell
E5Z46_RS17350	COG1846	Transcriptional regulator
E5Z46_RS17355	COG1785	Belongs to the alkaline phosphatase family
E5Z46_RS17360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Z46_RS17365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Z46_RS17370	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5Z46_RS17375	COG1910	domain protein
E5Z46_RS17385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5Z46_RS17395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Z46_RS17400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Z46_RS17420	COG1363	Peptidase, m42
E5Z46_RS17430	COG3326	Membrane
E5Z46_RS17435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5Z46_RS17450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5Z46_RS17460	COG1484	DNA-dependent DNA replication
E5Z46_RS17465	COG3611	Membrane attachment protein
E5Z46_RS17470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Z46_RS17480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E5Z46_RS17485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5Z46_RS17490	COG0237	dephospho-CoA kinase activity
E5Z46_RS17495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5Z46_RS17505	COG5002	protein histidine kinase activity
E5Z46_RS17510	COG0745	RESPONSE REGULATOR receiver
E5Z46_RS17520	COG0039	L-malate dehydrogenase activity
E5Z46_RS17525	COG0538	isocitrate dehydrogenase activity
E5Z46_RS17530	COG0372	Belongs to the citrate synthase family
E5Z46_RS17535	COG2707	UPF0756 membrane protein
E5Z46_RS17540	COG0628	permease
E5Z46_RS17550	COG0205	6-phosphofructokinase activity
E5Z46_RS17555	COG0825	malonyl-CoA metabolic process
E5Z46_RS17560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5Z46_RS17570	COG0587	DNA-directed DNA polymerase activity
E5Z46_RS17585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5Z46_RS17595	COG4109	DRTGG domain
E5Z46_RS17600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5Z46_RS17605	COG0006	proline dipeptidase activity
E5Z46_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS17620	COG0589	response to stress
E5Z46_RS17625	COG0165	Argininosuccinate lyase
E5Z46_RS17630	COG0137	argininosuccinate synthase activity
E5Z46_RS17640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Z46_RS17645	COG0640	Transcriptional regulator
E5Z46_RS17655	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5Z46_RS17670	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5Z46_RS17700	COG1012	belongs to the aldehyde dehydrogenase family
E5Z46_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z46_RS17735	COG1024	Enoyl-CoA hydratase
E5Z46_RS17740	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS17745	COG1960	acyl-CoA dehydrogenase activity
E5Z46_RS17750	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS17770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5Z46_RS17775	COG0827	DNA restriction-modification system
E5Z46_RS17780	COG3344	reverse transcriptase
E5Z46_RS17790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E5Z46_RS17795	COG3874	Sporulation protein YtfJ
E5Z46_RS17805	COG1714	RDD family
E5Z46_RS17810	COG0616	signal peptide processing
E5Z46_RS17815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5Z46_RS17820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Z46_RS17830	COG0301	tRNA thio-modification
E5Z46_RS17835	COG1104	cysteine desulfurase activity
E5Z46_RS17845	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
E5Z46_RS17850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5Z46_RS17855	COG1956	GAF domain-containing protein
E5Z46_RS17860	COG2199	diguanylate cyclase activity
E5Z46_RS17860	COG2203	Gaf domain
E5Z46_RS17865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5Z46_RS17870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5Z46_RS17880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Z46_RS17885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Z46_RS17895	COG0454	-acetyltransferase
E5Z46_RS17900	COG0517	IMP dehydrogenase activity
E5Z46_RS17905	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5Z46_RS17915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E5Z46_RS17915	COG1605	Chorismate mutase
E5Z46_RS17920	COG3118	belongs to the thioredoxin family
E5Z46_RS17935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Z46_RS17940	COG1674	ftsk spoiiie
E5Z46_RS17945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Z46_RS17950	COG4848	Belongs to the UPF0354 family
E5Z46_RS17955	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E5Z46_RS17960	COG1363	Peptidase, m42
E5Z46_RS17970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z46_RS17975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5Z46_RS17985	COG0510	thiamine kinase activity
E5Z46_RS17990	COG1523	belongs to the glycosyl hydrolase 13 family
E5Z46_RS18010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5Z46_RS18015	COG1349	DNA-binding transcription factor activity
E5Z46_RS18020	COG1187	pseudouridine synthase activity
E5Z46_RS18030	COG2244	polysaccharide biosynthetic process
E5Z46_RS18035	COG2081	HI0933 family
E5Z46_RS18070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Z46_RS18075	COG0495	leucyl-tRNA aminoacylation
E5Z46_RS18080	COG2814	Major facilitator Superfamily
E5Z46_RS18095	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E5Z46_RS18105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5Z46_RS18110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5Z46_RS18115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E5Z46_RS18135	COG1506	peptidase
E5Z46_RS18140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5Z46_RS18145	COG1116	anion transmembrane transporter activity
E5Z46_RS18150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5Z46_RS18155	COG0494	nUDIX hydrolase
E5Z46_RS18165	COG4824	toxin secretion phage lysis holin
E5Z46_RS18170	COG0783	Belongs to the Dps family
E5Z46_RS18185	COG1854	S-ribosylhomocysteine lyase activity
E5Z46_RS18190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5Z46_RS18205	COG3344	reverse transcriptase
E5Z46_RS18240	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z46_RS18245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5Z46_RS18250	COG0596	Alpha beta hydrolase
E5Z46_RS18255	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E5Z46_RS18260	COG1169	isochorismate synthase
E5Z46_RS18265	COG1575	Belongs to the MenA family. Type 1 subfamily
E5Z46_RS18270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5Z46_RS18290	COG1280	lysine exporter protein (LysE YggA)
E5Z46_RS18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS18320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Z46_RS18325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E5Z46_RS18450	COG1285	pathogenesis
E5Z46_RS18680	COG2002	toxin-antitoxin pair type II binding
E5Z46_RS18720	COG0582	viral genome integration into host DNA
E5Z46_RS18890	COG0358	DNA primase activity
E5Z46_RS18910	COG0587	DNA-directed DNA polymerase activity
E5Z46_RS18935	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E5Z46_RS18945	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5Z46_RS18950	COG2131	deaminase
E5Z46_RS18985	COG1247	-acetyltransferase
E5Z46_RS18995	COG3344	reverse transcriptase
E5Z46_RS19010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5Z46_RS19020	COG0166	Belongs to the GPI family
E5Z46_RS19025	COG1979	alcohol dehydrogenase
E5Z46_RS19030	COG2155	Conserved Protein
E5Z46_RS19035	COG1098	S1 RNA binding domain
E5Z46_RS19040	COG0436	Aminotransferase
E5Z46_RS19045	COG1522	sequence-specific DNA binding
E5Z46_RS19055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5Z46_RS19065	COG2032	superoxide dismutase activity
E5Z46_RS19075	COG5018	Exonuclease