locus-tag	class	description
GTHT12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTHT12_RS00010	COG0592	DNA-directed DNA polymerase activity
GTHT12_RS00015	COG2501	S4 domain
GTHT12_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTHT12_RS00025	COG0187	DNA topoisomerase II activity
GTHT12_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTHT12_RS00035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTHT12_RS00070	COG0516	GMP reductase activity
GTHT12_RS00070	COG0517	IMP dehydrogenase activity
GTHT12_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GTHT12_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GTHT12_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTHT12_RS00095	COG3858	chitin binding
GTHT12_RS00095	COG1388	LysM domain
GTHT12_RS00100	COG0590	tRNA wobble adenosine to inosine editing
GTHT12_RS00110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GTHT12_RS00115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTHT12_RS00120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTHT12_RS00165	COG1982	Orn Lys Arg decarboxylase major
GTHT12_RS00170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTHT12_RS00175	COG0470	DNA polymerase III
GTHT12_RS00180	COG1774	PSP1 C-terminal conserved region
GTHT12_RS00185	COG4467	Involved in initiation control of chromosome replication
GTHT12_RS00190	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GTHT12_RS00195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTHT12_RS00200	COG2002	toxin-antitoxin pair type II binding
GTHT12_RS00210	COG0084	hydrolase, TatD family'
GTHT12_RS00215	COG3583	domain protein
GTHT12_RS00215	COG3584	3D domain protein
GTHT12_RS00225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTHT12_RS00235	COG4466	Protein conserved in bacteria
GTHT12_RS00245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTHT12_RS00250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTHT12_RS00255	COG0251	oxidation-reduction process
GTHT12_RS00260	COG2088	sporulation resulting in formation of a cellular spore
GTHT12_RS00265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTHT12_RS00275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GTHT12_RS00280	COG0193	aminoacyl-tRNA hydrolase activity
GTHT12_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTHT12_RS00300	COG2002	toxin-antitoxin pair type II binding
GTHT12_RS00310	COG2244	polysaccharide biosynthetic process
GTHT12_RS00315	COG3956	TIGRFAM MazG family protein
GTHT12_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTHT12_RS00340	COG1098	S1 RNA binding domain
GTHT12_RS00355	COG2208	phosphoserine phosphatase activity
GTHT12_RS00360	COG2304	oxidoreductase activity
GTHT12_RS00365	COG0515	serine threonine protein kinase
GTHT12_RS00370	COG0037	tRNA processing
GTHT12_RS00375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GTHT12_RS00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTHT12_RS00385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GTHT12_RS00390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTHT12_RS00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTHT12_RS00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTHT12_RS00405	COG0512	Glutamine amidotransferase of anthranilate synthase
GTHT12_RS00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTHT12_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTHT12_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTHT12_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTHT12_RS00430	COG1396	sequence-specific DNA binding
GTHT12_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTHT12_RS00510	COG3880	PFAM UvrB UvrC protein
GTHT12_RS00515	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GTHT12_RS00520	COG0542	response to heat
GTHT12_RS00525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTHT12_RS00530	COG4956	integral membrane protein (PIN domain superfamily)
GTHT12_RS00535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GTHT12_RS00540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GTHT12_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTHT12_RS00550	COG1045	serine acetyltransferase
GTHT12_RS00555	COG0215	cysteine-tRNA ligase activity
GTHT12_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTHT12_RS00570	COG3688	RNA-binding protein containing a PIN domain
GTHT12_RS00580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTHT12_RS00585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTHT12_RS00590	COG0250	Participates in transcription elongation, termination and antitermination
GTHT12_RS00595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTHT12_RS00600	COG0081	regulation of translation
GTHT12_RS00605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTHT12_RS00610	COG0222	ribosome binding
GTHT12_RS00615	COG2813	Specifically methylates the guanine in position
GTHT12_RS00620	COG0085	RNA polymerase activity
GTHT12_RS00625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTHT12_RS00630	COG1358	cellular component organization or biogenesis
GTHT12_RS00635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GTHT12_RS00640	COG0049	tRNA binding
GTHT12_RS00645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTHT12_RS00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTHT12_RS00655	COG0051	transcription antitermination factor activity, RNA binding
GTHT12_RS00660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTHT12_RS00665	COG0088	Forms part of the polypeptide exit tunnel
GTHT12_RS00670	COG0089	rRNA binding
GTHT12_RS00675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTHT12_RS00680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTHT12_RS00685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTHT12_RS00690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTHT12_RS00695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTHT12_RS00700	COG0255	Belongs to the universal ribosomal protein uL29 family
GTHT12_RS00705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTHT12_RS00710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTHT12_RS00720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTHT12_RS00725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTHT12_RS00730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTHT12_RS00740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTHT12_RS00745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTHT12_RS00750	COG1841	ribosomal large subunit assembly
GTHT12_RS00755	COG0200	Binds to the 23S rRNA
GTHT12_RS00760	COG0201	protein transport
GTHT12_RS00765	COG0563	adenylate kinase activity
GTHT12_RS00770	COG0024	Methionine aminopeptidase
GTHT12_RS00775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTHT12_RS00780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTHT12_RS00785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTHT12_RS00790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTHT12_RS00795	COG0202	RNA polymerase activity
GTHT12_RS00800	COG0203	ribosomal protein L17
GTHT12_RS00805	COG1122	ATPase activity
GTHT12_RS00810	COG1122	ATPase activity
GTHT12_RS00815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTHT12_RS00820	COG0101	tRNA pseudouridine synthase activity
GTHT12_RS00825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTHT12_RS00830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTHT12_RS00840	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTHT12_RS00845	COG0489	protein tyrosine kinase activity
GTHT12_RS00855	COG2194	sulfuric ester hydrolase activity
GTHT12_RS00860	COG0726	polysaccharide deacetylase
GTHT12_RS00920	COG1595	DNA-templated transcription, initiation
GTHT12_RS00925	COG5662	AntiSigma factor
GTHT12_RS00930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GTHT12_RS00935	COG4856	YbbR-like protein
GTHT12_RS00940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTHT12_RS00945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTHT12_RS00955	COG0180	Tryptophanyl-tRNA synthetase
GTHT12_RS00960	COG3328	transposase activity
GTHT12_RS00965	COG2274	protein secretion by the type I secretion system
GTHT12_RS00975	COG1131	(ABC) transporter
GTHT12_RS00995	COG0426	domain, Protein
GTHT12_RS00995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTHT12_RS01010	COG4174	ABC transporter (Permease)
GTHT12_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS01025	COG1169	isochorismate synthase
GTHT12_RS01030	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTHT12_RS01035	COG1535	isochorismatase
GTHT12_RS01035	COG3433	isochorismatase activity
GTHT12_RS01040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTHT12_RS01045	COG3251	PFAM MbtH domain protein
GTHT12_RS01050	COG2091	lysine biosynthetic process via aminoadipic acid
GTHT12_RS01055	COG2207	Transcriptional regulator
GTHT12_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTHT12_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTHT12_RS01065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS01075	COG0778	Nitroreductase
GTHT12_RS01080	COG2819	hydrolase of the alpha beta superfamily
GTHT12_RS01085	COG2819	hydrolase of the alpha beta superfamily
GTHT12_RS01095	COG3655	Transcriptional regulator
GTHT12_RS01100	COG3739	integral membrane protein
GTHT12_RS01125	COG2259	Doxx family
GTHT12_RS01130	COG3829	transcription factor binding
GTHT12_RS01135	COG0833	amino acid
GTHT12_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS01145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTHT12_RS01150	COG0586	Pfam SNARE associated Golgi protein
GTHT12_RS01155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS01160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS01165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTHT12_RS01170	COG1120	ATPase activity
GTHT12_RS01175	COG3829	transcription factor binding
GTHT12_RS01175	COG3290	protein histidine kinase activity
GTHT12_RS01180	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS01190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GTHT12_RS01195	COG2318	DinB family
GTHT12_RS01200	COG2205	protein histidine kinase activity
GTHT12_RS01205	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS01230	COG1404	Belongs to the peptidase S8 family
GTHT12_RS01235	COG1368	sulfuric ester hydrolase activity
GTHT12_RS01240	COG1971	Probably functions as a manganese efflux pump
GTHT12_RS01250	COG1940	carbohydrate kinase activity
GTHT12_RS01255	COG1968	undecaprenyl-diphosphatase activity
GTHT12_RS01260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTHT12_RS01275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTHT12_RS01280	COG1181	Belongs to the D-alanine--D-alanine ligase family
GTHT12_RS01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTHT12_RS01295	COG0513	Belongs to the DEAD box helicase family
GTHT12_RS01300	COG0705	Rhomboid family
GTHT12_RS01305	COG0736	holo-[acyl-carrier-protein] synthase activity
GTHT12_RS01310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GTHT12_RS01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTHT12_RS01320	COG0864	Transcriptional regulator
GTHT12_RS01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
GTHT12_RS01330	COG2183	response to ionizing radiation
GTHT12_RS01340	COG3091	SprT-like family
GTHT12_RS01420	COG0802	atpase or kinase
GTHT12_RS01425	COG1214	PFAM Peptidase M22, glycoprotease
GTHT12_RS01430	COG0456	acetyltransferase
GTHT12_RS01435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTHT12_RS01445	COG0488	(ABC) transporter
GTHT12_RS01450	COG0315	cyclic pyranopterin monophosphate synthase activity
GTHT12_RS01455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GTHT12_RS01460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTHT12_RS01465	COG0805	protein transport
GTHT12_RS01475	COG1266	CAAX protease self-immunity
GTHT12_RS01480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTHT12_RS01485	COG0459	protein refolding
GTHT12_RS01495	COG0475	glutathione-regulated potassium exporter activity
GTHT12_RS01500	COG0490	domain, Protein
GTHT12_RS01505	COG0114	fumarate hydratase activity
GTHT12_RS01510	COG1914	H( )-stimulated, divalent metal cation uptake system
GTHT12_RS01515	COG0714	Associated with various cellular activities
GTHT12_RS01520	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GTHT12_RS01530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTHT12_RS01530	COG0519	Catalyzes the synthesis of GMP from XMP
GTHT12_RS01535	COG3328	transposase activity
GTHT12_RS01555	COG0519	Catalyzes the synthesis of GMP from XMP
GTHT12_RS01560	COG2252	PERMEase
GTHT12_RS01565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTHT12_RS01590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTHT12_RS01595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTHT12_RS01600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTHT12_RS01605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTHT12_RS01610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTHT12_RS01615	COG0047	phosphoribosylformylglycinamidine synthase activity
GTHT12_RS01620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTHT12_RS01625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTHT12_RS01630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTHT12_RS01635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTHT12_RS01640	COG0138	bifunctional purine biosynthesis protein purh
GTHT12_RS01645	COG0151	Belongs to the GarS family
GTHT12_RS01655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTHT12_RS01660	COG1470	cell adhesion involved in biofilm formation
GTHT12_RS01670	COG4496	protein, YerC YecD
GTHT12_RS01675	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GTHT12_RS01685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTHT12_RS01690	COG4851	CamS sex pheromone cAM373 precursor
GTHT12_RS01695	COG1611	Belongs to the LOG family
GTHT12_RS01700	COG1231	oxidoreductase activity
GTHT12_RS01715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTHT12_RS01720	COG0154	amidase activity
GTHT12_RS01725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTHT12_RS01760	COG5002	protein histidine kinase activity
GTHT12_RS01780	COG1131	(ABC) transporter
GTHT12_RS01785	COG1174	glycine betaine transport
GTHT12_RS01790	COG1125	glycine betaine transport
GTHT12_RS01790	COG0517	IMP dehydrogenase activity
GTHT12_RS01795	COG1732	Glycine betaine
GTHT12_RS01805	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GTHT12_RS01825	COG2610	gluconate transmembrane transporter activity
GTHT12_RS01845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GTHT12_RS01850	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS01860	COG2814	Major facilitator Superfamily
GTHT12_RS01875	COG5002	protein histidine kinase activity
GTHT12_RS01885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTHT12_RS01895	COG4145	pantothenate transmembrane transporter activity
GTHT12_RS01900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTHT12_RS01905	COG0473	3-isopropylmalate dehydrogenase activity
GTHT12_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS01920	COG0501	Belongs to the peptidase M48B family
GTHT12_RS01935	COG2268	Band 7 protein
GTHT12_RS01940	COG1597	lipid kinase activity
GTHT12_RS01945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTHT12_RS01950	COG1823	symporter activity
GTHT12_RS01955	COG1136	(ABC) transporter
GTHT12_RS01960	COG0577	efflux transmembrane transporter activity
GTHT12_RS01965	COG5294	Protein conserved in bacteria
GTHT12_RS01995	COG1695	Transcriptional regulator
GTHT12_RS02040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTHT12_RS02075	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GTHT12_RS02085	COG4824	toxin secretion phage lysis holin
GTHT12_RS02095	COG1396	sequence-specific DNA binding
GTHT12_RS02100	COG3328	transposase activity
GTHT12_RS02150	COG1966	Carbon starvation protein
GTHT12_RS02175	COG4326	sporulation control protein
GTHT12_RS02185	COG5002	protein histidine kinase activity
GTHT12_RS02190	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS02200	COG1136	(ABC) transporter
GTHT12_RS02200	COG0577	efflux transmembrane transporter activity
GTHT12_RS02205	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS02210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GTHT12_RS02230	COG2197	response regulator
GTHT12_RS02245	COG2208	phosphoserine phosphatase activity
GTHT12_RS02255	COG1714	RDD family
GTHT12_RS02260	COG0840	transmembrane signaling receptor activity
GTHT12_RS02260	COG3290	protein histidine kinase activity
GTHT12_RS02265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GTHT12_RS02270	COG0436	Aminotransferase
GTHT12_RS02275	COG0028	Belongs to the TPP enzyme family
GTHT12_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS02290	COG2814	Major facilitator Superfamily
GTHT12_RS02295	COG0789	Transcriptional regulator
GTHT12_RS02315	COG2068	MobA-Related Protein
GTHT12_RS02320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GTHT12_RS02340	COG2986	histidine ammonia-lyase
GTHT12_RS02345	COG1388	LysM domain
GTHT12_RS02345	COG3858	chitin binding
GTHT12_RS02350	COG0861	Integral membrane protein TerC family
GTHT12_RS02360	COG1556	Lactate utilization protein
GTHT12_RS02365	COG1139	Iron-sulfur cluster binding protein
GTHT12_RS02370	COG0247	lactate metabolic process
GTHT12_RS02375	COG2186	Transcriptional regulator
GTHT12_RS02380	COG1620	l-lactate permease
GTHT12_RS02385	COG0277	FAD linked oxidase domain protein
GTHT12_RS02390	COG0247	lactate metabolic process
GTHT12_RS02395	COG1077	Cell shape determining protein MreB Mrl
GTHT12_RS02400	COG1388	LysM domain
GTHT12_RS02400	COG0791	NLP P60 protein
GTHT12_RS02405	COG3300	MHYT domain
GTHT12_RS02405	COG5001	Diguanylate cyclase
GTHT12_RS02420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTHT12_RS02420	COG1648	precorrin-2 dehydrogenase activity
GTHT12_RS02430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTHT12_RS02435	COG0010	Belongs to the arginase family
GTHT12_RS02440	COG1254	Belongs to the acylphosphatase family
GTHT12_RS02455	COG0529	Catalyzes the synthesis of activated sulfate
GTHT12_RS02460	COG2046	Belongs to the sulfate adenylyltransferase family
GTHT12_RS02465	COG0306	phosphate transporter
GTHT12_RS02470	COG0175	sulfate reduction
GTHT12_RS02475	COG4840	Belongs to the UPF0435 family
GTHT12_RS02480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTHT12_RS02485	COG1295	ribonuclease BN
GTHT12_RS02495	COG0477	Major facilitator Superfamily
GTHT12_RS02500	COG0387	Pfam Sodium calcium exchanger
GTHT12_RS02510	COG0535	radical SAM domain protein
GTHT12_RS02525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTHT12_RS02530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTHT12_RS02540	COG0477	Major facilitator Superfamily
GTHT12_RS02570	COG3328	transposase activity
GTHT12_RS02625	COG4842	Belongs to the WXG100 family
GTHT12_RS02630	COG5417	Belongs to the EsaB family
GTHT12_RS02635	COG4499	WXG100 protein secretion system (Wss), protein YukC
GTHT12_RS02640	COG1674	ftsk spoiiie
GTHT12_RS02645	COG1511	domain protein
GTHT12_RS02795	COG4585	Histidine kinase
GTHT12_RS02800	COG2197	response regulator
GTHT12_RS02805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GTHT12_RS02810	COG0789	Transcriptional regulator
GTHT12_RS02820	COG5001	Diguanylate cyclase
GTHT12_RS02825	COG5001	Diguanylate cyclase
GTHT12_RS02825	COG5002	protein histidine kinase activity
GTHT12_RS02835	COG5609	conserved protein (DUF2294)
GTHT12_RS02840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTHT12_RS02845	COG3002	Belongs to the UPF0753 family
GTHT12_RS02850	COG1595	DNA-templated transcription, initiation
GTHT12_RS02865	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS02875	COG0768	penicillin binding
GTHT12_RS02880	COG1442	glycosyl transferase family 8
GTHT12_RS02905	COG1090	epimerase
GTHT12_RS02910	COG2137	regulation of response to DNA damage stimulus
GTHT12_RS02930	COG1988	membrane-bound metal-dependent
GTHT12_RS02935	COG2427	Protein of unknown function (DUF1641)
GTHT12_RS02940	COG3383	formate dehydrogenase (NAD+) activity
GTHT12_RS02945	COG5609	conserved protein (DUF2294)
GTHT12_RS02950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GTHT12_RS02955	COG2223	nitrite transmembrane transporter activity
GTHT12_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS02985	COG3557	Belongs to the UPF0374 family
GTHT12_RS02990	COG1132	(ABC) transporter
GTHT12_RS02995	COG0444	Belongs to the ABC transporter superfamily
GTHT12_RS03000	COG4608	Belongs to the ABC transporter superfamily
GTHT12_RS03005	COG0747	negative chemotaxis
GTHT12_RS03010	COG0601	transmembrane transport
GTHT12_RS03015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTHT12_RS03020	COG4129	membrane
GTHT12_RS03045	COG2274	protein secretion by the type I secretion system
GTHT12_RS03050	COG2312	Erythromycin esterase
GTHT12_RS03055	COG3328	transposase activity
GTHT12_RS03110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTHT12_RS03115	COG4555	ABC transporter
GTHT12_RS03130	COG0039	L-malate dehydrogenase activity
GTHT12_RS03140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTHT12_RS03145	COG0735	belongs to the Fur family
GTHT12_RS03280	COG3382	B3 4 domain protein
GTHT12_RS03305	COG2766	serine protein kinase
GTHT12_RS03325	COG1609	Transcriptional regulator
GTHT12_RS03335	COG3290	protein histidine kinase activity
GTHT12_RS03340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTHT12_RS03345	COG1301	dicarboxylic acid transport
GTHT12_RS03350	COG0656	L-ascorbic acid biosynthetic process
GTHT12_RS03355	COG2738	Putative neutral zinc metallopeptidase
GTHT12_RS03360	COG1253	flavin adenine dinucleotide binding
GTHT12_RS03365	COG0564	pseudouridine synthase activity
GTHT12_RS03385	COG0517	IMP dehydrogenase activity
GTHT12_RS03390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTHT12_RS03405	COG0586	Pfam SNARE associated Golgi protein
GTHT12_RS03410	COG2719	SpoVR family
GTHT12_RS03415	COG1271	oxidase subunit
GTHT12_RS03420	COG1294	oxidase, subunit
GTHT12_RS03440	COG0861	Integral membrane protein TerC family
GTHT12_RS03450	COG1966	Carbon starvation protein
GTHT12_RS03455	COG2879	small protein
GTHT12_RS03460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTHT12_RS03465	COG0366	Alpha amylase catalytic
GTHT12_RS03470	COG2318	DinB family
GTHT12_RS03475	COG2814	Major facilitator Superfamily
GTHT12_RS03480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTHT12_RS03485	COG4721	ABC-type cobalt transport system, permease component
GTHT12_RS03490	COG1122	ATPase activity
GTHT12_RS03495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTHT12_RS03500	COG0352	thiamine-phosphate diphosphorylase activity
GTHT12_RS03505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTHT12_RS03515	COG2022	thiamine diphosphate biosynthetic process
GTHT12_RS03520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTHT12_RS03525	COG1253	flavin adenine dinucleotide binding
GTHT12_RS03540	COG3842	ATPase activity
GTHT12_RS03545	COG2508	Transcriptional regulator
GTHT12_RS03565	COG0189	ligase activity
GTHT12_RS03570	COG0189	ligase activity
GTHT12_RS03580	COG4399	Belongs to the UPF0754 family
GTHT12_RS03585	COG3679	Belongs to the UPF0342 family
GTHT12_RS03590	COG0561	phosphatase activity
GTHT12_RS03595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTHT12_RS03605	COG4152	abc transporter atp-binding protein
GTHT12_RS03610	COG1668	transmembrane transport
GTHT12_RS03615	COG3481	metal-dependent phosphohydrolase, HD sub domain
GTHT12_RS03625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GTHT12_RS03640	COG1846	Transcriptional regulator
GTHT12_RS03660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTHT12_RS03665	COG0537	adenosine 5'-monophosphoramidase activity
GTHT12_RS03670	COG1131	(ABC) transporter
GTHT12_RS03675	COG4473	ABC transporter
GTHT12_RS03680	COG3069	C4-dicarboxylate transmembrane transporter activity
GTHT12_RS03685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GTHT12_RS03690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GTHT12_RS03695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GTHT12_RS03700	COG1309	transcriptional regulator
GTHT12_RS03705	COG1511	domain protein
GTHT12_RS03715	COG1234	tRNA 3'-trailer cleavage
GTHT12_RS03720	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS03735	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GTHT12_RS03745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GTHT12_RS03760	COG2224	Isocitrate lyase
GTHT12_RS03775	COG0398	Pfam SNARE associated Golgi protein
GTHT12_RS03785	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GTHT12_RS03790	COG1074	ATP-dependent DNA helicase activity
GTHT12_RS03795	COG0420	3'-5' exonuclease activity
GTHT12_RS03800	COG0419	ATPase involved in DNA repair
GTHT12_RS03850	COG2311	Membrane
GTHT12_RS03860	COG0179	Fumarylacetoacetate (FAA) hydrolase
GTHT12_RS03880	COG0367	asparagine synthase
GTHT12_RS03885	COG0534	Mate efflux family protein
GTHT12_RS03890	COG1917	Cupin 2, conserved barrel domain protein
GTHT12_RS03890	COG2207	Transcriptional regulator
GTHT12_RS03900	COG2182	Extracellular solute-binding protein
GTHT12_RS03905	COG1175	transmembrane transport
GTHT12_RS03910	COG3833	ABC-type maltose transport systems, permease component
GTHT12_RS03915	COG0366	Alpha amylase catalytic
GTHT12_RS03930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTHT12_RS03935	COG0022	dehydrogenase e1 component
GTHT12_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS03955	COG1410	methionine synthase
GTHT12_RS03955	COG0646	methionine synthase
GTHT12_RS03960	COG0646	methionine synthase
GTHT12_RS03960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GTHT12_RS03970	COG3842	ATPase activity
GTHT12_RS03975	COG1176	ABC-type spermidine putrescine transport system, permease component I
GTHT12_RS03980	COG1177	transmembrane transport
GTHT12_RS03985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTHT12_RS04000	COG1666	GTP binding
GTHT12_RS04010	COG1307	EDD domain protein, DegV family
GTHT12_RS04020	COG0561	phosphatase activity
GTHT12_RS04025	COG1073	alpha beta
GTHT12_RS04040	COG2151	metal-sulfur cluster biosynthetic enzyme
GTHT12_RS04060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTHT12_RS04075	COG0746	molybdenum cofactor guanylyltransferase activity
GTHT12_RS04085	COG0535	radical SAM domain protein
GTHT12_RS04100	COG2223	nitrite transmembrane transporter activity
GTHT12_RS04110	COG0028	Belongs to the TPP enzyme family
GTHT12_RS04120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GTHT12_RS04125	COG1140	nitrate reductase beta subunit
GTHT12_RS04130	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GTHT12_RS04135	COG2181	nitrate reductase activity
GTHT12_RS04140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTHT12_RS04145	COG4149	molybdate abc transporter
GTHT12_RS04150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTHT12_RS04165	COG0303	'Molybdopterin
GTHT12_RS04170	COG1763	Mo-molybdopterin cofactor biosynthetic process
GTHT12_RS04175	COG0314	molybdopterin synthase activity
GTHT12_RS04180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTHT12_RS04195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTHT12_RS04200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTHT12_RS04205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GTHT12_RS04210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTHT12_RS04240	COG0542	response to heat
GTHT12_RS04260	COG2267	carboxylic ester hydrolase activity
GTHT12_RS04270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTHT12_RS04275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTHT12_RS04280	COG5504	Zn-dependent protease
GTHT12_RS04305	COG4166	transmembrane transport
GTHT12_RS04310	COG0601	transmembrane transport
GTHT12_RS04315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTHT12_RS04320	COG0444	Belongs to the ABC transporter superfamily
GTHT12_RS04325	COG4608	Belongs to the ABC transporter superfamily
GTHT12_RS04335	COG1393	Belongs to the ArsC family
GTHT12_RS04340	COG0861	Integral membrane protein TerC family
GTHT12_RS04345	COG4862	establishment of competence for transformation
GTHT12_RS04350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTHT12_RS04360	COG1164	Oligoendopeptidase f
GTHT12_RS04370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GTHT12_RS04375	COG2346	COG2346, Truncated hemoglobins
GTHT12_RS04380	COG0741	lytic transglycosylase activity
GTHT12_RS04385	COG4116	CYTH
GTHT12_RS04395	COG2357	RelA SpoT domain protein
GTHT12_RS04405	COG0564	pseudouridine synthase activity
GTHT12_RS04410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GTHT12_RS04415	COG0772	Belongs to the SEDS family
GTHT12_RS04430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTHT12_RS04435	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS04440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTHT12_RS04450	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS04455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTHT12_RS04460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GTHT12_RS04520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTHT12_RS04535	COG2323	membrane
GTHT12_RS04540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTHT12_RS04560	COG2153	protein acetylation
GTHT12_RS04565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GTHT12_RS04570	COG2382	esterase
GTHT12_RS04575	COG0626	cystathionine gamma-synthase activity
GTHT12_RS04580	COG0626	cystathionine gamma-synthase activity
GTHT12_RS04595	COG1215	transferase activity, transferring glycosyl groups
GTHT12_RS04600	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS04640	COG0582	viral genome integration into host DNA
GTHT12_RS04665	COG3328	transposase activity
GTHT12_RS04710	COG3328	transposase activity
GTHT12_RS04730	COG3402	PFAM membrane-flanked domain
GTHT12_RS04735	COG1733	regulation of RNA biosynthetic process
GTHT12_RS04740	COG2814	Major facilitator Superfamily
GTHT12_RS04745	COG0656	L-ascorbic acid biosynthetic process
GTHT12_RS04755	COG0656	L-ascorbic acid biosynthetic process
GTHT12_RS04785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GTHT12_RS04810	COG0367	asparagine synthase
GTHT12_RS04815	COG5002	protein histidine kinase activity
GTHT12_RS04835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTHT12_RS04840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTHT12_RS04865	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GTHT12_RS04870	COG1418	mRNA catabolic process
GTHT12_RS04885	COG0477	Major facilitator Superfamily
GTHT12_RS04895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTHT12_RS04900	COG1597	lipid kinase activity
GTHT12_RS04910	COG2966	Psort location CytoplasmicMembrane, score
GTHT12_RS04920	COG1473	amidohydrolase
GTHT12_RS04930	COG4948	Mandelate Racemase Muconate Lactonizing
GTHT12_RS04935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTHT12_RS04940	COG3162	membrane
GTHT12_RS04945	COG0531	amino acid
GTHT12_RS04950	COG1191	sigma factor activity
GTHT12_RS04965	COG1609	Transcriptional regulator
GTHT12_RS04975	COG1653	transport
GTHT12_RS04985	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS05000	COG5002	protein histidine kinase activity
GTHT12_RS05005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTHT12_RS05010	COG4214	carbohydrate transport
GTHT12_RS05020	COG1879	ABC-type sugar transport system periplasmic component
GTHT12_RS05025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GTHT12_RS05030	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GTHT12_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTHT12_RS05040	COG0436	Aminotransferase
GTHT12_RS05045	COG1850	ribulose-bisphosphate carboxylase activity
GTHT12_RS05050	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GTHT12_RS05055	COG0235	Class ii aldolase
GTHT12_RS05060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GTHT12_RS05070	COG1846	Transcriptional regulator
GTHT12_RS05075	COG4869	propanediol catabolic process
GTHT12_RS05085	COG0823	Involved in the tonB-independent uptake of proteins
GTHT12_RS05085	COG1506	peptidase
GTHT12_RS05085	COG4946	Tricorn protease homolog
GTHT12_RS05095	COG0531	amino acid
GTHT12_RS05100	COG3328	transposase activity
GTHT12_RS05115	COG1131	(ABC) transporter
GTHT12_RS05130	COG0542	response to heat
GTHT12_RS05140	COG3949	Membrane
GTHT12_RS05160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GTHT12_RS05165	COG0720	synthase
GTHT12_RS05175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTHT12_RS05180	COG0702	epimerase
GTHT12_RS05185	COG4873	Protein conserved in bacteria
GTHT12_RS05195	COG4974	Belongs to the 'phage' integrase family
GTHT12_RS05210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTHT12_RS05310	COG3773	Cell wall hydrolase
GTHT12_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS05335	COG4191	Histidine kinase
GTHT12_RS05340	COG0778	Nitroreductase
GTHT12_RS05345	COG0596	Alpha beta hydrolase
GTHT12_RS05350	COG3711	transcriptional antiterminator
GTHT12_RS05355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTHT12_RS05355	COG1263	PTS System
GTHT12_RS05355	COG2190	(PTS) system
GTHT12_RS05385	COG0840	transmembrane signaling receptor activity
GTHT12_RS05390	COG0567	Dehydrogenase, E1 component
GTHT12_RS05395	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTHT12_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS05410	COG2084	Dehydrogenase
GTHT12_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS05425	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS05430	COG1309	transcriptional regulator
GTHT12_RS05440	COG2045	Belongs to the ComB family
GTHT12_RS05450	COG0436	Aminotransferase
GTHT12_RS05460	COG0598	Magnesium transport protein CorA
GTHT12_RS05480	COG1408	metallophosphoesterase
GTHT12_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS05490	COG2200	EAL domain
GTHT12_RS05505	COG0517	IMP dehydrogenase activity
GTHT12_RS05515	COG0583	DNA-binding transcription factor activity
GTHT12_RS05520	COG2171	N-acyltransferase activity
GTHT12_RS05525	COG1473	amidohydrolase
GTHT12_RS05535	COG0450	alkyl hydroperoxide reductase
GTHT12_RS05540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTHT12_RS05545	COG0569	domain protein
GTHT12_RS05555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GTHT12_RS05560	COG5503	Protein of unknown function (DUF1447)
GTHT12_RS05565	COG0561	phosphatase activity
GTHT12_RS05610	COG1982	Orn Lys Arg decarboxylase major
GTHT12_RS05620	COG4476	Belongs to the UPF0223 family
GTHT12_RS05630	COG0483	inositol monophosphate 1-phosphatase activity
GTHT12_RS05635	COG1217	gtp-binding protein TYPA
GTHT12_RS05650	COG4896	Protein conserved in bacteria
GTHT12_RS05660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GTHT12_RS05665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GTHT12_RS05670	COG4838	Belongs to the UPF0358 family
GTHT12_RS05675	COG0772	Belongs to the SEDS family
GTHT12_RS05680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GTHT12_RS05685	COG1612	heme a metabolic process
GTHT12_RS05690	COG0109	protoheme IX farnesyltransferase activity
GTHT12_RS05715	COG3336	cytochrome c oxidase
GTHT12_RS05735	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GTHT12_RS05740	COG2340	Cysteine-rich secretory protein family
GTHT12_RS05760	COG3679	Belongs to the UPF0342 family
GTHT12_RS05765	COG4471	UPF0298 protein
GTHT12_RS05775	COG0742	ribosomal rna small subunit methyltransferase
GTHT12_RS05780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTHT12_RS05785	COG3314	Sporulation integral membrane protein YlbJ
GTHT12_RS05790	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTHT12_RS05795	COG3480	Lon protease (S16) C-terminal proteolytic domain
GTHT12_RS05800	COG1323	Belongs to the UPF0348 family
GTHT12_RS05805	COG1399	metal-binding, possibly nucleic acid-binding protein
GTHT12_RS05810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTHT12_RS05815	COG1024	Enoyl-CoA hydratase
GTHT12_RS05825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTHT12_RS05835	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GTHT12_RS05840	COG0275	rRNA processing
GTHT12_RS05845	COG4839	cell division protein FtsL
GTHT12_RS05850	COG0768	penicillin binding
GTHT12_RS05855	COG0768	penicillin binding
GTHT12_RS05860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTHT12_RS05870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTHT12_RS05875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTHT12_RS05880	COG0772	Belongs to the SEDS family
GTHT12_RS05885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTHT12_RS05890	COG3879	Bacterial protein of unknown function (DUF881)
GTHT12_RS05895	COG3879	Bacterial protein of unknown function (DUF881)
GTHT12_RS05900	COG3856	small basic protein
GTHT12_RS05905	COG0849	cell division
GTHT12_RS05910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTHT12_RS05925	COG1191	sigma factor activity
GTHT12_RS05930	COG1191	sigma factor activity
GTHT12_RS05935	COG1873	PFAM PRC-barrel domain
GTHT12_RS05945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTHT12_RS05950	COG1799	cell septum assembly
GTHT12_RS05955	COG0762	integral membrane protein
GTHT12_RS05960	COG2302	S4 RNA-binding domain
GTHT12_RS05965	COG3599	regulation of cell shape
GTHT12_RS05970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GTHT12_RS05975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GTHT12_RS05980	COG0564	pseudouridine synthase activity
GTHT12_RS05985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GTHT12_RS05995	COG0540	Belongs to the ATCase OTCase family
GTHT12_RS06000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GTHT12_RS06015	COG0543	2 iron, 2 sulfur cluster binding
GTHT12_RS06020	COG0167	dihydroorotate dehydrogenase activity
GTHT12_RS06025	COG0284	orotidine-5'-phosphate decarboxylase activity
GTHT12_RS06055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTHT12_RS06060	COG1561	YicC-like family, N-terminal region
GTHT12_RS06065	COG2052	Domain of unknown function (DUF370)
GTHT12_RS06070	COG0194	GDP metabolic process
GTHT12_RS06075	COG1758	RNA polymerase activity
GTHT12_RS06080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTHT12_RS06085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTHT12_RS06090	COG0242	peptide deformylase activity
GTHT12_RS06095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTHT12_RS06100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTHT12_RS06100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTHT12_RS06105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GTHT12_RS06110	COG0631	protein serine/threonine phosphatase activity
GTHT12_RS06115	COG0515	serine threonine protein kinase
GTHT12_RS06115	COG2815	serine threonine protein kinase
GTHT12_RS06120	COG1162	GTPase activity
GTHT12_RS06125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTHT12_RS06130	COG1564	THIamine pyrophosphokinase
GTHT12_RS06140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTHT12_RS06145	COG1302	Protein conserved in bacteria
GTHT12_RS06150	COG1461	Dihydroxyacetone kinase
GTHT12_RS06155	COG1760	l-serine dehydratase
GTHT12_RS06160	COG1760	l-serine dehydratase
GTHT12_RS06165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTHT12_RS06170	COG1349	DNA-binding transcription factor activity
GTHT12_RS06170	COG2050	protein possibly involved in aromatic compounds catabolism
GTHT12_RS06175	COG0416	fatty acid biosynthetic process
GTHT12_RS06180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTHT12_RS06185	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS06190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTHT12_RS06195	COG0571	ribonuclease III activity
GTHT12_RS06200	COG1196	nuclear chromosome segregation
GTHT12_RS06205	COG0552	protein localization to endoplasmic reticulum
GTHT12_RS06210	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GTHT12_RS06215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTHT12_RS06220	COG0228	four-way junction DNA binding
GTHT12_RS06225	COG1837	Belongs to the UPF0109 family
GTHT12_RS06235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTHT12_RS06240	COG0336	Belongs to the RNA methyltransferase TrmD family
GTHT12_RS06255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTHT12_RS06260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTHT12_RS06270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTHT12_RS06275	COG0045	succinate-CoA ligase (ADP-forming) activity
GTHT12_RS06280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GTHT12_RS06285	COG0758	DNA mediated transformation
GTHT12_RS06290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTHT12_RS06295	COG4974	Belongs to the 'phage' integrase family
GTHT12_RS06300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GTHT12_RS06305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTHT12_RS06310	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GTHT12_RS06315	COG1815	bacterial-type flagellum-dependent cell motility
GTHT12_RS06320	COG1558	bacterial-type flagellum-dependent cell motility
GTHT12_RS06325	COG1677	Flagellar hook-basal body complex protein FliE
GTHT12_RS06330	COG1766	The M ring may be actively involved in energy transduction
GTHT12_RS06335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTHT12_RS06340	COG1317	bacterial-type flagellum organization
GTHT12_RS06345	COG1157	protein secretion by the type III secretion system
GTHT12_RS06350	COG2882	bacterial-type flagellum organization
GTHT12_RS06360	COG3144	bacterial-type flagellum assembly
GTHT12_RS06365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GTHT12_RS06370	COG4786	Flagellar basal body rod
GTHT12_RS06375	COG1582	Flagellar protein (FlbD)
GTHT12_RS06380	COG1580	Controls the rotational direction of flagella during chemotaxis
GTHT12_RS06385	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTHT12_RS06390	COG1776	CheC inhibitor of MCP methylation
GTHT12_RS06390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTHT12_RS06395	COG2201	protein-glutamate methylesterase activity
GTHT12_RS06400	COG3190	flagellar
GTHT12_RS06405	COG1338	Plays a role in the flagellum-specific transport system
GTHT12_RS06410	COG1987	bacterial-type flagellum assembly
GTHT12_RS06415	COG1684	flagellar biosynthetic protein fliR
GTHT12_RS06420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTHT12_RS06425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTHT12_RS06430	COG1419	protein localization to endoplasmic reticulum
GTHT12_RS06435	COG0455	bacterial-type flagellum organization
GTHT12_RS06440	COG2201	protein-glutamate methylesterase activity
GTHT12_RS06445	COG0643	Histidine kinase
GTHT12_RS06445	COG2198	Histidine kinase
GTHT12_RS06450	COG0835	chemotaxis
GTHT12_RS06455	COG1776	CheC inhibitor of MCP methylation
GTHT12_RS06460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GTHT12_RS06465	COG1191	sigma factor activity
GTHT12_RS06480	COG0052	Belongs to the universal ribosomal protein uS2 family
GTHT12_RS06485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTHT12_RS06490	COG0528	UMP kinase activity
GTHT12_RS06495	COG0233	cytoplasmic translational termination
GTHT12_RS06500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTHT12_RS06505	COG4589	Belongs to the CDS family
GTHT12_RS06510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTHT12_RS06515	COG0750	zinc metalloprotease
GTHT12_RS06520	COG0442	prolyl-tRNA aminoacylation
GTHT12_RS06525	COG2176	DNA-directed DNA polymerase activity
GTHT12_RS06530	COG0779	Required for maturation of 30S ribosomal subunits
GTHT12_RS06535	COG0195	Participates in both transcription termination and antitermination
GTHT12_RS06540	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GTHT12_RS06545	COG1358	cellular component organization or biogenesis
GTHT12_RS06550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTHT12_RS06555	COG1550	Protein conserved in bacteria
GTHT12_RS06560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTHT12_RS06565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GTHT12_RS06570	COG0196	riboflavin kinase activity
GTHT12_RS06575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTHT12_RS06580	COG1185	polyribonucleotide nucleotidyltransferase activity
GTHT12_RS06585	COG0726	polysaccharide deacetylase
GTHT12_RS06590	COG0612	Peptidase, M16
GTHT12_RS06595	COG1873	PFAM PRC-barrel domain
GTHT12_RS06600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTHT12_RS06605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTHT12_RS06610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTHT12_RS06615	COG0527	aspartate kinase activity
GTHT12_RS06620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTHT12_RS06625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GTHT12_RS06630	COG0740	serine-type endopeptidase activity
GTHT12_RS06645	COG4980	gas vesicle protein
GTHT12_RS06645	COG1674	ftsk spoiiie
GTHT12_RS06650	COG2188	Transcriptional regulator
GTHT12_RS06655	COG1744	ABC transporter substrate-binding protein PnrA-like
GTHT12_RS06660	COG3845	ABC transporter
GTHT12_RS06665	COG4603	Belongs to the binding-protein-dependent transport system permease family
GTHT12_RS06670	COG1079	Belongs to the binding-protein-dependent transport system permease family
GTHT12_RS06675	COG0612	Peptidase, M16
GTHT12_RS06680	COG0612	Peptidase, M16
GTHT12_RS06685	COG0300	oxidoreductase activity
GTHT12_RS06700	COG1426	Protein conserved in bacteria
GTHT12_RS06705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTHT12_RS06710	COG1058	Belongs to the CinA family
GTHT12_RS06710	COG1546	Belongs to the CinA family
GTHT12_RS06720	COG1418	mRNA catabolic process
GTHT12_RS06725	COG1692	metallophosphoesterase
GTHT12_RS06730	COG2359	stage V sporulation protein S
GTHT12_RS06740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTHT12_RS06740	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTHT12_RS06745	COG1013	pyruvate-flavodoxin oxidoreductase activity
GTHT12_RS06750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTHT12_RS06755	COG4550	Control of competence regulator ComK, YlbF/YmcA
GTHT12_RS06765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTHT12_RS06770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTHT12_RS06775	COG0791	NLP P60 protein
GTHT12_RS06775	COG1388	LysM domain
GTHT12_RS06780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTHT12_RS06785	COG0477	Major facilitator Superfamily
GTHT12_RS06790	COG0840	transmembrane signaling receptor activity
GTHT12_RS06795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTHT12_RS06800	COG1923	regulation of RNA biosynthetic process
GTHT12_RS06805	COG0464	growth
GTHT12_RS06815	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS06820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GTHT12_RS06825	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTHT12_RS06835	COG0183	Belongs to the thiolase family
GTHT12_RS06840	COG0697	spore germination
GTHT12_RS06850	COG2860	membrane
GTHT12_RS06855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTHT12_RS06860	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GTHT12_RS06865	COG0789	Transcriptional regulator
GTHT12_RS06870	COG0174	glutamine synthetase
GTHT12_RS06875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTHT12_RS06880	COG1388	LysM domain
GTHT12_RS06885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTHT12_RS06890	COG4224	UPF0291 protein
GTHT12_RS06905	COG3763	UPF0154 protein
GTHT12_RS06910	COG1132	(ABC) transporter
GTHT12_RS06915	COG1132	(ABC) transporter
GTHT12_RS06925	COG0785	Cytochrome C biogenesis protein
GTHT12_RS06930	COG2201	protein-glutamate methylesterase activity
GTHT12_RS06935	COG4846	Membrane protein involved in cytochrome C biogenesis
GTHT12_RS06945	COG3773	Cell wall hydrolase
GTHT12_RS06950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GTHT12_RS06950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTHT12_RS06990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GTHT12_RS07000	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GTHT12_RS07010	COG0328	RNA-DNA hybrid ribonuclease activity
GTHT12_RS07040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTHT12_RS07065	COG0010	Belongs to the arginase family
GTHT12_RS07070	COG4977	sequence-specific DNA binding
GTHT12_RS07070	COG1917	Cupin 2, conserved barrel domain protein
GTHT12_RS07075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GTHT12_RS07080	COG1228	amidohydrolase
GTHT12_RS07085	COG3314	Sporulation integral membrane protein YlbJ
GTHT12_RS07095	COG1970	mechanosensitive ion channel activity
GTHT12_RS07100	COG2391	methyltransferase activity
GTHT12_RS07105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS07110	COG2313	pseudouridylate synthase activity
GTHT12_RS07115	COG3384	dioxygenase
GTHT12_RS07120	COG0662	Cupin 2, conserved barrel domain protein
GTHT12_RS07230	COG0579	oxidoreductase
GTHT12_RS07240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTHT12_RS07245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GTHT12_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS07280	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GTHT12_RS07290	COG1595	DNA-templated transcription, initiation
GTHT12_RS07300	COG0393	Putative heavy-metal-binding
GTHT12_RS07305	COG0640	Transcriptional regulator
GTHT12_RS07315	COG0583	DNA-binding transcription factor activity
GTHT12_RS07320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTHT12_RS07325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTHT12_RS07335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS07340	COG4605	iron ion homeostasis
GTHT12_RS07345	COG4604	ABC transporter, ATP-binding protein
GTHT12_RS07350	COG4607	ABC-type enterochelin transport system periplasmic component
GTHT12_RS07375	COG1113	amino acid transport
GTHT12_RS07380	COG3835	regulator
GTHT12_RS07385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTHT12_RS07390	COG0604	alcohol dehydrogenase
GTHT12_RS07395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTHT12_RS07400	COG1472	Belongs to the glycosyl hydrolase 3 family
GTHT12_RS07405	COG3876	Protein conserved in bacteria
GTHT12_RS07410	COG0583	DNA-binding transcription factor activity
GTHT12_RS07415	COG0070	glutamate synthase
GTHT12_RS07415	COG0067	glutamate synthase
GTHT12_RS07415	COG0069	glutamate synthase activity
GTHT12_RS07420	COG0493	'glutamate synthase
GTHT12_RS07440	COG3001	Fructosamine kinase
GTHT12_RS07445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTHT12_RS07450	COG0693	protein deglycase activity
GTHT12_RS07455	COG0697	spore germination
GTHT12_RS07465	COG4821	SIS domain
GTHT12_RS07480	COG2340	Cysteine-rich secretory protein family
GTHT12_RS07505	COG3853	Toxic anion resistance protein (TelA)
GTHT12_RS07525	COG0004	ammonium transporteR
GTHT12_RS07545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTHT12_RS07550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS07555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS07560	COG1120	ATPase activity
GTHT12_RS07595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GTHT12_RS07600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GTHT12_RS07610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTHT12_RS07625	COG4555	ABC transporter
GTHT12_RS07645	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS07650	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS07655	COG0475	glutathione-regulated potassium exporter activity
GTHT12_RS07655	COG0569	domain protein
GTHT12_RS07665	COG2135	peptidase activity
GTHT12_RS07680	COG2814	Major facilitator Superfamily
GTHT12_RS07685	COG1464	Belongs to the NlpA lipoprotein family
GTHT12_RS07690	COG2011	ABC-type metal ion transport system permease component
GTHT12_RS07695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTHT12_RS07700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GTHT12_RS07700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTHT12_RS07705	COG0456	acetyltransferase
GTHT12_RS07710	COG1414	Transcriptional regulator
GTHT12_RS07715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GTHT12_RS07720	COG1984	allophanate hydrolase subunit 2
GTHT12_RS07725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GTHT12_RS07730	COG1914	H( )-stimulated, divalent metal cation uptake system
GTHT12_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS07755	COG0463	Glycosyl transferase, family 2
GTHT12_RS07760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GTHT12_RS07765	COG0351	phosphomethylpyrimidine kinase
GTHT12_RS07770	COG0352	thiamine-phosphate diphosphorylase activity
GTHT12_RS07775	COG3594	Acyltransferase
GTHT12_RS07790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTHT12_RS07795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTHT12_RS07805	COG5577	PFAM Coat F domain
GTHT12_RS07820	COG5002	protein histidine kinase activity
GTHT12_RS07830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTHT12_RS07840	COG0670	Belongs to the BI1 family
GTHT12_RS07850	COG1131	(ABC) transporter
GTHT12_RS07860	COG3622	Belongs to the hyi family
GTHT12_RS07870	COG0277	FAD linked oxidase domain protein
GTHT12_RS07875	COG0247	lactate metabolic process
GTHT12_RS07880	COG0277	FAD linked oxidase domain protein
GTHT12_RS07885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GTHT12_RS07890	COG0281	malic enzyme
GTHT12_RS07895	COG0179	Fumarylacetoacetate (FAA) hydrolase
GTHT12_RS07900	COG1414	Transcriptional regulator
GTHT12_RS07905	COG1205	dead DEAH box helicase
GTHT12_RS07905	COG1111	helicase
GTHT12_RS07910	COG3359	exonuclease
GTHT12_RS07925	COG3599	regulation of cell shape
GTHT12_RS07935	COG0116	Belongs to the methyltransferase superfamily
GTHT12_RS07940	COG1199	ATP-dependent helicase activity
GTHT12_RS07945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTHT12_RS07955	COG2801	Transposase and inactivated derivatives
GTHT12_RS07960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTHT12_RS07965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GTHT12_RS07975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTHT12_RS07980	COG2233	PERMEase
GTHT12_RS07985	COG1136	(ABC) transporter
GTHT12_RS07990	COG0577	efflux transmembrane transporter activity
GTHT12_RS08005	COG3424	synthase
GTHT12_RS08010	COG1755	Isoprenylcysteine carboxyl methyltransferase
GTHT12_RS08015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GTHT12_RS08035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTHT12_RS08055	COG0824	Thioesterase
GTHT12_RS08065	COG2050	protein possibly involved in aromatic compounds catabolism
GTHT12_RS08070	COG4841	protein insertion into membrane
GTHT12_RS08090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTHT12_RS08095	COG4479	Belongs to the UPF0346 family
GTHT12_RS08130	COG0813	purine-nucleoside phosphorylase activity
GTHT12_RS08135	COG1876	peptidase activity
GTHT12_RS08140	COG2226	methyltransferase
GTHT12_RS08145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTHT12_RS08155	COG0598	Magnesium transport protein CorA
GTHT12_RS08165	COG2962	Rard protein
GTHT12_RS08185	COG0534	Mate efflux family protein
GTHT12_RS08190	COG3852	Histidine kinase
GTHT12_RS08195	COG2814	Major facilitator Superfamily
GTHT12_RS08200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GTHT12_RS08220	COG1309	transcriptional regulator
GTHT12_RS08225	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS08230	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS08235	COG0439	Biotin carboxylase
GTHT12_RS08240	COG0511	ligase activity, forming carbon-carbon bonds
GTHT12_RS08245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GTHT12_RS08250	COG1024	Enoyl-CoA hydratase
GTHT12_RS08255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GTHT12_RS08270	COG1566	PFAM secretion protein HlyD family protein
GTHT12_RS08275	COG2814	Major facilitator Superfamily
GTHT12_RS08300	COG2205	protein histidine kinase activity
GTHT12_RS08305	COG2223	nitrite transmembrane transporter activity
GTHT12_RS08330	COG1725	Transcriptional regulator
GTHT12_RS08335	COG1131	(ABC) transporter
GTHT12_RS08350	COG0697	spore germination
GTHT12_RS08360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTHT12_RS08365	COG2208	phosphoserine phosphatase activity
GTHT12_RS08380	COG1132	(ABC) transporter
GTHT12_RS08385	COG1132	(ABC) transporter
GTHT12_RS08390	COG2258	MOSC domain
GTHT12_RS08395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTHT12_RS08415	COG0730	response to heat
GTHT12_RS08425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS08435	COG0800	Aldolase
GTHT12_RS08440	COG1609	Transcriptional regulator
GTHT12_RS08445	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GTHT12_RS08455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS08470	COG1131	(ABC) transporter
GTHT12_RS08475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GTHT12_RS08495	COG1741	Belongs to the pirin family
GTHT12_RS08500	COG0778	Nitroreductase
GTHT12_RS08505	COG2814	Major facilitator Superfamily
GTHT12_RS08510	COG3226	Transcriptional regulator
GTHT12_RS08520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTHT12_RS08530	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS08540	COG2030	dehydratase
GTHT12_RS08550	COG0183	Belongs to the thiolase family
GTHT12_RS08555	COG1309	transcriptional regulator
GTHT12_RS08560	COG0559	Belongs to the binding-protein-dependent transport system permease family
GTHT12_RS08595	COG1612	heme a metabolic process
GTHT12_RS08605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTHT12_RS08635	COG1119	ATPase activity
GTHT12_RS08660	COG1024	Enoyl-CoA hydratase
GTHT12_RS08665	COG0515	serine threonine protein kinase
GTHT12_RS08675	COG0551	DNA topoisomerase type I activity
GTHT12_RS08675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTHT12_RS08685	COG1937	Protein conserved in bacteria
GTHT12_RS08690	COG2217	Heavy metal translocating P-type atpase
GTHT12_RS08695	COG2608	mercury ion transmembrane transporter activity
GTHT12_RS08710	COG1113	amino acid transport
GTHT12_RS08725	COG1279	arginine transmembrane transporter activity
GTHT12_RS08750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTHT12_RS08755	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GTHT12_RS08785	COG4294	response to UV
GTHT12_RS08805	COG2200	EAL domain
GTHT12_RS08820	COG2197	response regulator
GTHT12_RS08845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GTHT12_RS08870	COG0488	(ABC) transporter
GTHT12_RS08900	COG0500	methyltransferase
GTHT12_RS08910	COG3620	sequence-specific DNA binding
GTHT12_RS08945	COG0243	molybdopterin cofactor binding
GTHT12_RS08950	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GTHT12_RS08970	COG1247	-acetyltransferase
GTHT12_RS08975	COG1660	Displays ATPase and GTPase activities
GTHT12_RS09015	COG3328	transposase activity
GTHT12_RS09030	COG0640	Transcriptional regulator
GTHT12_RS09035	COG0798	PFAM Bile acid sodium symporter
GTHT12_RS09040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTHT12_RS09050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTHT12_RS09060	COG1247	-acetyltransferase
GTHT12_RS09085	COG2404	hydrolase activity, acting on ester bonds
GTHT12_RS09090	COG4548	von Willebrand factor, type A
GTHT12_RS09095	COG0714	Associated with various cellular activities
GTHT12_RS09105	COG0788	formyltetrahydrofolate deformylase activity
GTHT12_RS09110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTHT12_RS09110	COG1017	nitric oxide dioxygenase activity
GTHT12_RS09115	COG1959	2 iron, 2 sulfur cluster binding
GTHT12_RS09120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GTHT12_RS09125	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS09140	COG1757	Na H antiporter
GTHT12_RS09145	COG2188	Transcriptional regulator
GTHT12_RS09150	COG0366	Alpha amylase catalytic
GTHT12_RS09155	COG1263	PTS System
GTHT12_RS09155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTHT12_RS09165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTHT12_RS09170	COG0187	DNA topoisomerase II activity
GTHT12_RS09175	COG1832	CoA-binding protein
GTHT12_RS09185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GTHT12_RS09195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS09245	COG3647	Membrane
GTHT12_RS09260	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GTHT12_RS09265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTHT12_RS09270	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTHT12_RS09290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTHT12_RS09295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GTHT12_RS09295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTHT12_RS09305	COG2755	lipolytic protein G-D-S-L family
GTHT12_RS09310	COG1999	signal sequence binding
GTHT12_RS09320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GTHT12_RS09330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTHT12_RS09335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GTHT12_RS09350	COG0436	Aminotransferase
GTHT12_RS09365	COG1413	lyase activity
GTHT12_RS09370	COG0386	Belongs to the glutathione peroxidase family
GTHT12_RS09405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GTHT12_RS09410	COG1492	cobalamin metabolic process
GTHT12_RS09440	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GTHT12_RS09465	COG1122	ATPase activity
GTHT12_RS09470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTHT12_RS09475	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GTHT12_RS09480	COG0310	cobalt ion transport
GTHT12_RS09505	COG0584	glycerophosphoryl diester phosphodiesterase
GTHT12_RS09510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTHT12_RS09515	COG4989	oxidoreductase activity
GTHT12_RS09525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTHT12_RS09530	COG1335	isochorismatase
GTHT12_RS09535	COG0706	membrane insertase activity
GTHT12_RS09560	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GTHT12_RS09565	COG1140	nitrate reductase beta subunit
GTHT12_RS09570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GTHT12_RS09575	COG2181	nitrate reductase activity
GTHT12_RS09580	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GTHT12_RS09585	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTHT12_RS09590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTHT12_RS09595	COG1587	Uroporphyrinogen-III synthase
GTHT12_RS09615	COG5002	protein histidine kinase activity
GTHT12_RS09620	COG0024	Methionine aminopeptidase
GTHT12_RS09625	COG0432	Pfam Uncharacterised protein family UPF0047
GTHT12_RS09635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTHT12_RS09635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTHT12_RS09635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTHT12_RS09640	COG1105	Belongs to the carbohydrate kinase PfkB family
GTHT12_RS09645	COG1349	DNA-binding transcription factor activity
GTHT12_RS09655	COG1131	(ABC) transporter
GTHT12_RS09685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTHT12_RS09685	COG2199	diguanylate cyclase activity
GTHT12_RS09715	COG0385	Bile acid
GTHT12_RS09730	COG1408	metallophosphoesterase
GTHT12_RS09735	COG0726	polysaccharide deacetylase
GTHT12_RS09740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTHT12_RS09745	COG2188	Transcriptional regulator
GTHT12_RS09750	COG2723	6-phospho-beta-galactosidase activity
GTHT12_RS09755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTHT12_RS09760	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTHT12_RS09765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTHT12_RS09770	COG0789	Transcriptional regulator
GTHT12_RS09785	COG1454	alcohol dehydrogenase
GTHT12_RS09795	COG1070	Carbohydrate kinase
GTHT12_RS09800	COG2115	Belongs to the xylose isomerase family
GTHT12_RS09805	COG3507	Belongs to the glycosyl hydrolase 43 family
GTHT12_RS09830	COG5578	integral membrane protein
GTHT12_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS09840	COG1312	Catalyzes the dehydration of D-mannonate
GTHT12_RS09845	COG1904	glucuronate isomerase
GTHT12_RS09850	COG1802	Transcriptional regulator
GTHT12_RS09855	COG0800	Aldolase
GTHT12_RS09860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS09875	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS09880	COG4209	transmembrane transport
GTHT12_RS09910	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS09915	COG1175	transmembrane transport
GTHT12_RS09925	COG2207	Transcriptional regulator
GTHT12_RS09930	COG2972	Histidine kinase
GTHT12_RS09945	COG0371	Dehydrogenase
GTHT12_RS09950	COG0647	UMP catabolic process
GTHT12_RS09965	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS09970	COG1175	transmembrane transport
GTHT12_RS09975	COG1653	transport
GTHT12_RS09980	COG2160	L-arabinose isomerase activity
GTHT12_RS09985	COG1069	ribulokinase activity
GTHT12_RS10000	COG4214	carbohydrate transport
GTHT12_RS10010	COG4213	ABC transporter substrate-binding protein
GTHT12_RS10015	COG4753	response regulator
GTHT12_RS10015	COG2207	Transcriptional regulator
GTHT12_RS10020	COG2972	Histidine kinase
GTHT12_RS10040	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS10045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS10050	COG3718	enzyme involved in inositol metabolism
GTHT12_RS10055	COG1082	Xylose isomerase domain protein TIM barrel
GTHT12_RS10060	COG3962	Belongs to the TPP enzyme family
GTHT12_RS10065	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS10070	COG1609	Transcriptional regulator
GTHT12_RS10075	COG1879	ABC-type sugar transport system periplasmic component
GTHT12_RS10080	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTHT12_RS10095	COG1129	ABC transporter
GTHT12_RS10105	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS10110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GTHT12_RS10120	COG4166	transmembrane transport
GTHT12_RS10125	COG4608	Belongs to the ABC transporter superfamily
GTHT12_RS10130	COG0444	Belongs to the ABC transporter superfamily
GTHT12_RS10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTHT12_RS10140	COG0601	transmembrane transport
GTHT12_RS10145	COG2362	D-Aminopeptidase
GTHT12_RS10150	COG1522	sequence-specific DNA binding
GTHT12_RS10165	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GTHT12_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS10175	COG1349	DNA-binding transcription factor activity
GTHT12_RS10180	COG4753	response regulator
GTHT12_RS10180	COG2207	Transcriptional regulator
GTHT12_RS10185	COG3275	phosphorelay sensor kinase activity
GTHT12_RS10190	COG3866	Pectate lyase
GTHT12_RS10195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GTHT12_RS10205	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS10210	COG1175	transmembrane transport
GTHT12_RS10215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS10225	COG2721	sulfolactate sulfo-lyase activity
GTHT12_RS10230	COG0246	Mannitol dehydrogenase
GTHT12_RS10235	COG1609	Transcriptional regulator
GTHT12_RS10240	COG1904	glucuronate isomerase
GTHT12_RS10245	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS10260	COG1301	dicarboxylic acid transport
GTHT12_RS10270	COG3833	ABC-type maltose transport systems, permease component
GTHT12_RS10290	COG1024	Enoyl-CoA hydratase
GTHT12_RS10295	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS10305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTHT12_RS10320	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GTHT12_RS10325	COG0110	maltose O-acetyltransferase activity
GTHT12_RS10335	COG0456	acetyltransferase
GTHT12_RS10340	COG2610	gluconate transmembrane transporter activity
GTHT12_RS10350	COG1609	Transcriptional regulator
GTHT12_RS10360	COG4565	transcriptional regulatory protein
GTHT12_RS10365	COG3290	protein histidine kinase activity
GTHT12_RS10385	COG0246	Mannitol dehydrogenase
GTHT12_RS10395	COG3711	transcriptional antiterminator
GTHT12_RS10410	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS10415	COG2610	gluconate transmembrane transporter activity
GTHT12_RS10435	COG4948	Mandelate Racemase Muconate Lactonizing
GTHT12_RS10445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS10450	COG2721	sulfolactate sulfo-lyase activity
GTHT12_RS10455	COG2721	sulfolactate sulfo-lyase activity
GTHT12_RS10465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTHT12_RS10470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GTHT12_RS10475	COG1691	(AIR) carboxylase
GTHT12_RS10480	COG1606	tRNA processing
GTHT12_RS10495	COG1414	Transcriptional regulator
GTHT12_RS10500	COG0129	dihydroxy-acid dehydratase activity
GTHT12_RS10510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTHT12_RS10515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTHT12_RS10520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTHT12_RS10525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTHT12_RS10530	COG0667	Aldo Keto reductase
GTHT12_RS10540	COG1263	PTS System
GTHT12_RS10540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTHT12_RS10545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTHT12_RS10550	COG1737	Transcriptional regulator
GTHT12_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS10575	COG1657	PFAM Prenyltransferase squalene oxidase
GTHT12_RS10590	COG2755	lipolytic protein G-D-S-L family
GTHT12_RS10595	COG0385	Bile acid
GTHT12_RS10600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTHT12_RS10615	COG1024	Enoyl-CoA hydratase
GTHT12_RS10630	COG2151	metal-sulfur cluster biosynthetic enzyme
GTHT12_RS10650	COG1024	Enoyl-CoA hydratase
GTHT12_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS10675	COG2843	Capsule synthesis protein
GTHT12_RS10690	COG3104	oligopeptide transport
GTHT12_RS10705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTHT12_RS10710	COG4120	Belongs to the binding-protein-dependent transport system permease family
GTHT12_RS10740	COG3327	negative regulation of DNA-templated transcription, initiation
GTHT12_RS10745	COG0183	Belongs to the thiolase family
GTHT12_RS10750	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTHT12_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS10760	COG1024	Enoyl-CoA hydratase
GTHT12_RS10765	COG1024	Enoyl-CoA hydratase
GTHT12_RS10775	COG2151	metal-sulfur cluster biosynthetic enzyme
GTHT12_RS10790	COG3396	Phenylacetate-CoA oxygenase
GTHT12_RS10795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GTHT12_RS10800	COG0129	dihydroxy-acid dehydratase activity
GTHT12_RS10805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTHT12_RS10810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTHT12_RS10815	COG2246	polysaccharide biosynthetic process
GTHT12_RS10830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTHT12_RS10835	COG0710	3-dehydroquinate dehydratase activity
GTHT12_RS10865	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS10870	COG0642	Histidine kinase
GTHT12_RS10900	COG0561	phosphatase activity
GTHT12_RS10930	COG0730	response to heat
GTHT12_RS10935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS10935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTHT12_RS10940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTHT12_RS10940	COG0425	Belongs to the sulfur carrier protein TusA family
GTHT12_RS10950	COG1054	Belongs to the UPF0176 family
GTHT12_RS10955	COG2210	Belongs to the sulfur carrier protein TusA family
GTHT12_RS10960	COG0425	Belongs to the sulfur carrier protein TusA family
GTHT12_RS10965	COG1937	Protein conserved in bacteria
GTHT12_RS10980	COG2801	Transposase and inactivated derivatives
GTHT12_RS10985	COG2814	Major facilitator Superfamily
GTHT12_RS10990	COG1664	Polymer-forming cytoskeletal
GTHT12_RS10995	COG1664	Polymer-forming cytoskeletal
GTHT12_RS11000	COG0789	Transcriptional regulator
GTHT12_RS11020	COG4608	Belongs to the ABC transporter superfamily
GTHT12_RS11025	COG0444	Belongs to the ABC transporter superfamily
GTHT12_RS11030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTHT12_RS11035	COG0601	transmembrane transport
GTHT12_RS11050	COG0747	negative chemotaxis
GTHT12_RS11060	COG3457	Alanine racemase
GTHT12_RS11065	COG0840	transmembrane signaling receptor activity
GTHT12_RS11065	COG3290	protein histidine kinase activity
GTHT12_RS11100	COG1061	Type III restriction enzyme res subunit
GTHT12_RS11120	COG1082	Xylose isomerase domain protein TIM barrel
GTHT12_RS11125	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS11135	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS11140	COG1609	Transcriptional regulator
GTHT12_RS11145	COG0477	Major facilitator Superfamily
GTHT12_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS11150	COG2030	dehydratase
GTHT12_RS11165	COG1653	transport
GTHT12_RS11175	COG2066	Belongs to the glutaminase family
GTHT12_RS11200	COG4377	Putative membrane peptidase family (DUF2324)
GTHT12_RS11210	COG0640	Transcriptional regulator
GTHT12_RS11220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTHT12_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS11245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTHT12_RS11250	COG1116	anion transmembrane transporter activity
GTHT12_RS11375	COG0071	Belongs to the small heat shock protein (HSP20) family
GTHT12_RS11380	COG1609	Transcriptional regulator
GTHT12_RS11385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GTHT12_RS11390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTHT12_RS11395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTHT12_RS11400	COG2217	Heavy metal translocating P-type atpase
GTHT12_RS11410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTHT12_RS11415	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GTHT12_RS11420	COG5002	protein histidine kinase activity
GTHT12_RS11425	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS11465	COG3331	DNA recombination
GTHT12_RS11470	COG4499	WXG100 protein secretion system (Wss), protein YukC
GTHT12_RS11470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTHT12_RS11480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTHT12_RS11485	COG3935	DnaD domain protein
GTHT12_RS11490	COG0017	Asparaginyl-tRNA synthetase
GTHT12_RS11515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTHT12_RS11515	COG1199	ATP-dependent helicase activity
GTHT12_RS11520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GTHT12_RS11525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GTHT12_RS11530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GTHT12_RS11540	COG0617	tRNA 3'-terminal CCA addition
GTHT12_RS11545	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS11550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTHT12_RS11555	COG1803	Methylglyoxal synthase
GTHT12_RS11560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTHT12_RS11565	COG1694	Mazg nucleotide pyrophosphohydrolase
GTHT12_RS11570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTHT12_RS11580	COG4347	Protein of unknown function (DUF1405)
GTHT12_RS11605	COG5582	Belongs to the UPF0302 family
GTHT12_RS11610	COG0457	Tetratricopeptide repeat
GTHT12_RS11615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GTHT12_RS11620	COG0287	Prephenate dehydrogenase
GTHT12_RS11625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTHT12_RS11630	COG0159	tryptophan synthase activity
GTHT12_RS11635	COG0133	tryptophan synthase activity
GTHT12_RS11640	COG0135	phosphoribosylanthranilate isomerase activity
GTHT12_RS11645	COG0134	indole-3-glycerol-phosphate synthase activity
GTHT12_RS11650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTHT12_RS11660	COG4401	Chorismate mutase type I
GTHT12_RS11665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GTHT12_RS11670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GTHT12_RS11675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTHT12_RS11680	COG0105	UTP biosynthetic process
GTHT12_RS11690	COG2226	methyltransferase
GTHT12_RS11705	COG0302	gtp cyclohydrolase
GTHT12_RS11715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GTHT12_RS11730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTHT12_RS11735	COG1160	GTP binding
GTHT12_RS11775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTHT12_RS11780	COG0697	spore germination
GTHT12_RS11785	COG0539	negative regulation of cytoplasmic translation
GTHT12_RS11790	COG0204	Acyl-transferase
GTHT12_RS11795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTHT12_RS11810	COG2959	enzyme of heme biosynthesis
GTHT12_RS11815	COG3409	Peptidoglycan-binding domain 1 protein
GTHT12_RS11815	COG3773	Cell wall hydrolase
GTHT12_RS11820	COG2339	peptidase activity
GTHT12_RS11830	COG0492	ferredoxin-NADP+ reductase activity
GTHT12_RS11835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTHT12_RS11845	COG1408	metallophosphoesterase
GTHT12_RS11865	COG3546	catalase activity
GTHT12_RS11880	COG1266	CAAX protease self-immunity
GTHT12_RS11885	COG0514	ATP-dependent DNA helicase (RecQ)
GTHT12_RS11890	COG4955	Helix-turn-helix domain
GTHT12_RS11905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTHT12_RS11910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTHT12_RS11920	COG1595	DNA-templated transcription, initiation
GTHT12_RS11935	COG2096	Adenosyltransferase
GTHT12_RS11950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GTHT12_RS11965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GTHT12_RS11970	COG1120	ATPase activity
GTHT12_RS11975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTHT12_RS11980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTHT12_RS11995	COG1263	PTS System
GTHT12_RS11995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTHT12_RS12000	COG2188	Transcriptional regulator
GTHT12_RS12005	COG0363	glucosamine-6-phosphate deaminase activity
GTHT12_RS12010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTHT12_RS12015	COG5002	protein histidine kinase activity
GTHT12_RS12020	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS12025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTHT12_RS12030	COG1333	cytochrome c biogenesis protein
GTHT12_RS12035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTHT12_RS12040	COG1187	pseudouridine synthase activity
GTHT12_RS12045	COG0700	Nucleoside recognition
GTHT12_RS12050	COG2715	membrane protein required for spore maturation
GTHT12_RS12055	COG1686	Belongs to the peptidase S11 family
GTHT12_RS12060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GTHT12_RS12080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GTHT12_RS12085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GTHT12_RS12090	COG1547	Domain of unknown function (DUF309)
GTHT12_RS12100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTHT12_RS12105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTHT12_RS12105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTHT12_RS12110	COG0307	riboflavin synthase, alpha
GTHT12_RS12115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTHT12_RS12115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTHT12_RS12120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTHT12_RS12125	COG4086	secreted protein
GTHT12_RS12130	COG0019	diaminopimelate decarboxylase activity
GTHT12_RS12140	COG0697	spore germination
GTHT12_RS12155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTHT12_RS12185	COG2172	sigma factor antagonist activity
GTHT12_RS12195	COG1686	Belongs to the peptidase S11 family
GTHT12_RS12210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTHT12_RS12215	COG4974	Belongs to the 'phage' integrase family
GTHT12_RS12225	COG0735	belongs to the Fur family
GTHT12_RS12230	COG1300	Membrane
GTHT12_RS12235	COG1379	DNA repair
GTHT12_RS12240	COG0494	nUDIX hydrolase
GTHT12_RS12245	COG0667	Aldo Keto reductase
GTHT12_RS12250	COG2807	transmembrane transport
GTHT12_RS12265	COG4918	Iron-sulphur cluster biosynthesis
GTHT12_RS12280	COG0300	oxidoreductase activity
GTHT12_RS12285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS12290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTHT12_RS12295	COG1902	pentaerythritol trinitrate reductase activity
GTHT12_RS12300	COG1234	tRNA 3'-trailer cleavage
GTHT12_RS12305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTHT12_RS12310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GTHT12_RS12315	COG2723	6-phospho-beta-galactosidase activity
GTHT12_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS12330	COG1473	amidohydrolase
GTHT12_RS12340	COG0006	proline dipeptidase activity
GTHT12_RS12345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTHT12_RS12355	COG0835	chemotaxis
GTHT12_RS12360	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTHT12_RS12365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GTHT12_RS12370	COG0346	lactoylglutathione lyase activity
GTHT12_RS12375	COG1376	ErfK ybiS ycfS ynhG family protein
GTHT12_RS12380	COG4129	membrane
GTHT12_RS12390	COG1703	isobutyryl-CoA mutase activity
GTHT12_RS12395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GTHT12_RS12395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GTHT12_RS12405	COG5002	protein histidine kinase activity
GTHT12_RS12410	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS12420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTHT12_RS12425	COG0022	dehydrogenase e1 component
GTHT12_RS12430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTHT12_RS12435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTHT12_RS12450	COG0280	phosphate acetyltransferase
GTHT12_RS12455	COG3829	transcription factor binding
GTHT12_RS12455	COG3290	protein histidine kinase activity
GTHT12_RS12465	COG0584	glycerophosphoryl diester phosphodiesterase
GTHT12_RS12470	COG3093	addiction module antidote protein HigA
GTHT12_RS12490	COG0750	zinc metalloprotease
GTHT12_RS12495	COG0497	DNA recombination
GTHT12_RS12500	COG1438	arginine binding
GTHT12_RS12505	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GTHT12_RS12510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTHT12_RS12525	COG1722	exodeoxyribonuclease VII activity
GTHT12_RS12530	COG1570	exodeoxyribonuclease VII activity
GTHT12_RS12535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTHT12_RS12540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTHT12_RS12545	COG1302	Protein conserved in bacteria
GTHT12_RS12550	COG0439	Biotin carboxylase
GTHT12_RS12555	COG0511	ligase activity, forming carbon-carbon bonds
GTHT12_RS12595	COG3854	ATPases associated with a variety of cellular activities
GTHT12_RS12605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTHT12_RS12610	COG0006	proline dipeptidase activity
GTHT12_RS12620	COG3872	metal-dependent enzyme
GTHT12_RS12630	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTHT12_RS12635	COG1321	iron dependent repressor
GTHT12_RS12660	COG1301	dicarboxylic acid transport
GTHT12_RS12670	COG1388	LysM domain
GTHT12_RS12670	COG3858	chitin binding
GTHT12_RS12690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTHT12_RS12705	COG0095	Lipoate-protein ligase
GTHT12_RS12710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTHT12_RS12720	COG0667	Aldo Keto reductase
GTHT12_RS12730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTHT12_RS12735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GTHT12_RS12740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTHT12_RS12770	COG4968	Prepilin-type N-terminal cleavage methylation domain
GTHT12_RS12775	COG4537	Required for transformation and DNA binding
GTHT12_RS12780	COG1459	type II secretion system
GTHT12_RS12785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTHT12_RS12805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS12820	COG1940	carbohydrate kinase activity
GTHT12_RS12825	COG4483	Protein conserved in bacteria
GTHT12_RS12830	COG0697	spore germination
GTHT12_RS12840	COG0705	Rhomboid family
GTHT12_RS12840	COG0457	Tetratricopeptide repeat
GTHT12_RS12860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTHT12_RS12865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTHT12_RS12880	COG0704	Plays a role in the regulation of phosphate uptake
GTHT12_RS12885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTHT12_RS12895	COG0573	inorganic phosphate transmembrane transporter activity
GTHT12_RS12905	COG0768	penicillin binding
GTHT12_RS12910	COG0477	Major facilitator Superfamily
GTHT12_RS12920	COG5521	maltodextrose utilization protein MalA
GTHT12_RS12925	COG1388	LysM domain
GTHT12_RS12930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GTHT12_RS12935	COG4709	membrane
GTHT12_RS12940	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GTHT12_RS12945	COG0735	belongs to the Fur family
GTHT12_RS12950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTHT12_RS12955	COG1121	(ABC) transporter
GTHT12_RS12960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTHT12_RS12970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GTHT12_RS12975	COG0513	Belongs to the DEAD box helicase family
GTHT12_RS12985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GTHT12_RS12990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTHT12_RS12995	COG2384	SAM-dependent methyltransferase
GTHT12_RS13010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTHT12_RS13020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTHT12_RS13025	COG0517	IMP dehydrogenase activity
GTHT12_RS13030	COG1381	Involved in DNA repair and RecF pathway recombination
GTHT12_RS13040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTHT12_RS13045	COG0295	cytidine deaminase activity
GTHT12_RS13050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTHT12_RS13055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GTHT12_RS13060	COG1480	7TM receptor with intracellular HD hydrolase
GTHT12_RS13065	COG1702	phosphate starvation-inducible protein PhoH
GTHT12_RS13080	COG1610	YqeY-like protein
GTHT12_RS13085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTHT12_RS13090	COG1283	sodium-dependent phosphate transmembrane transporter activity
GTHT12_RS13095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTHT12_RS13105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTHT12_RS13110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTHT12_RS13115	COG2264	protein methyltransferase activity
GTHT12_RS13120	COG0484	heat shock protein binding
GTHT12_RS13125	COG0443	Heat shock 70 kDa protein
GTHT12_RS13130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTHT12_RS13135	COG1420	regulation of RNA biosynthetic process
GTHT12_RS13140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTHT12_RS13145	COG0481	GTPase activity
GTHT12_RS13155	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTHT12_RS13160	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GTHT12_RS13165	COG0268	Binds directly to 16S ribosomal RNA
GTHT12_RS13170	COG1466	dna polymerase III delta subunit
GTHT12_RS13180	COG2333	competence protein COMEC
GTHT12_RS13180	COG0658	competence protein
GTHT12_RS13185	COG2131	deaminase
GTHT12_RS13190	COG1555	photosystem II stabilization
GTHT12_RS13190	COG1596	polysaccharide export
GTHT12_RS13195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTHT12_RS13200	COG2226	methyltransferase
GTHT12_RS13205	COG0799	negative regulation of ribosome biogenesis
GTHT12_RS13210	COG1713	HD superfamily hydrolase involved in NAD metabolism
GTHT12_RS13215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTHT12_RS13220	COG1534	Rna-binding protein
GTHT12_RS13225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTHT12_RS13230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTHT12_RS13235	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GTHT12_RS13245	COG0688	phosphatidylethanolamine metabolic process
GTHT12_RS13250	COG1183	phosphatidylcholine synthase activity
GTHT12_RS13255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTHT12_RS13260	COG1360	Flagellar Motor Protein
GTHT12_RS13265	COG0628	permease
GTHT12_RS13295	COG0626	cystathionine gamma-synthase activity
GTHT12_RS13300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTHT12_RS13305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTHT12_RS13310	COG2226	methyltransferase
GTHT12_RS13325	COG0768	penicillin binding
GTHT12_RS13330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTHT12_RS13335	COG0572	uridine kinase
GTHT12_RS13340	COG0826	peptidase U32
GTHT12_RS13350	COG0826	peptidase U32
GTHT12_RS13355	COG4122	O-methyltransferase activity
GTHT12_RS13360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTHT12_RS13365	COG3906	Belongs to the UPF0473 family
GTHT12_RS13370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTHT12_RS13375	COG4472	Bacterial protein of unknown function (DUF965)
GTHT12_RS13380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTHT12_RS13385	COG0628	permease
GTHT12_RS13405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTHT12_RS13415	COG0482	sulfurtransferase activity
GTHT12_RS13420	COG1104	cysteine desulfurase activity
GTHT12_RS13425	COG1959	2 iron, 2 sulfur cluster binding
GTHT12_RS13435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTHT12_RS13445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTHT12_RS13455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTHT12_RS13460	COG0124	histidyl-tRNA synthetase
GTHT12_RS13465	COG3634	alkyl hydroperoxide reductase activity
GTHT12_RS13470	COG0450	alkyl hydroperoxide reductase
GTHT12_RS13475	COG1490	D-aminoacyl-tRNA deacylase activity
GTHT12_RS13480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTHT12_RS13485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTHT12_RS13490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GTHT12_RS13490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTHT12_RS13495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTHT12_RS13500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTHT12_RS13500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTHT12_RS13510	COG2244	polysaccharide biosynthetic process
GTHT12_RS13520	COG1862	Preprotein translocase
GTHT12_RS13525	COG0343	queuine tRNA-ribosyltransferase activity
GTHT12_RS13530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GTHT12_RS13540	COG2255	four-way junction helicase activity
GTHT12_RS13545	COG0632	four-way junction helicase activity
GTHT12_RS13555	COG0217	transcriptional regulatory protein
GTHT12_RS13565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTHT12_RS13575	COG1388	LysM domain
GTHT12_RS13580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTHT12_RS13585	COG0157	Belongs to the NadC ModD family
GTHT12_RS13590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GTHT12_RS13595	COG1104	cysteine desulfurase activity
GTHT12_RS13600	COG1827	regulation of RNA biosynthetic process
GTHT12_RS13605	COG0077	Prephenate dehydratase
GTHT12_RS13610	COG4492	Belongs to the UPF0735 family
GTHT12_RS13615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTHT12_RS13620	COG3290	protein histidine kinase activity
GTHT12_RS13625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTHT12_RS13630	COG2868	ribosomal protein
GTHT12_RS13635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTHT12_RS13640	COG1994	Peptidase M50
GTHT12_RS13645	COG0739	heme binding
GTHT12_RS13650	COG2894	cell division
GTHT12_RS13655	COG0850	regulation of cytokinetic process
GTHT12_RS13660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTHT12_RS13665	COG1792	Involved in formation and maintenance of cell shape
GTHT12_RS13670	COG1077	Cell shape determining protein MreB Mrl
GTHT12_RS13675	COG2003	Belongs to the UPF0758 family
GTHT12_RS13680	COG0424	maF-like protein
GTHT12_RS13710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTHT12_RS13715	COG2165	general secretion pathway protein
GTHT12_RS13720	COG1459	type II secretion system
GTHT12_RS13730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTHT12_RS13765	COG0285	dihydrofolate synthase activity
GTHT12_RS13790	COG1388	LysM domain
GTHT12_RS13790	COG1388	LysM domain
GTHT12_RS13795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTHT12_RS13800	COG0113	porphobilinogen synthase activity
GTHT12_RS13805	COG1587	Uroporphyrinogen-III synthase
GTHT12_RS13810	COG0181	hydroxymethylbilane synthase activity
GTHT12_RS13815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTHT12_RS13820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTHT12_RS13830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GTHT12_RS13835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTHT12_RS13840	COG0470	DNA polymerase III
GTHT12_RS13840	COG1067	ATP-dependent peptidase activity
GTHT12_RS13845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTHT12_RS13850	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTHT12_RS13855	COG1477	protein flavinylation
GTHT12_RS13855	COG0457	Tetratricopeptide repeat
GTHT12_RS13860	COG0066	3-isopropylmalate dehydratase activity
GTHT12_RS13865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GTHT12_RS13870	COG0473	3-isopropylmalate dehydrogenase activity
GTHT12_RS13875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GTHT12_RS13880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GTHT12_RS13885	COG0440	acetolactate synthase activity
GTHT12_RS13890	COG0028	Belongs to the TPP enzyme family
GTHT12_RS13900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTHT12_RS13905	COG0622	Phosphoesterase
GTHT12_RS13910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTHT12_RS13915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GTHT12_RS13920	COG5401	PFAM Sporulation and spore germination
GTHT12_RS13925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTHT12_RS13930	COG1846	Transcriptional regulator
GTHT12_RS13935	COG2197	response regulator
GTHT12_RS13940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTHT12_RS13945	COG1053	succinate dehydrogenase
GTHT12_RS13950	COG2009	succinate dehydrogenase
GTHT12_RS13955	COG1719	4-vinyl reductase, 4VR
GTHT12_RS13960	COG0322	excinuclease ABC activity
GTHT12_RS13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTHT12_RS13975	COG0431	NADPH-dependent FMN reductase
GTHT12_RS13980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTHT12_RS13985	COG1116	anion transmembrane transporter activity
GTHT12_RS13990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTHT12_RS13995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTHT12_RS14000	COG3118	belongs to the thioredoxin family
GTHT12_RS14005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GTHT12_RS14010	COG2086	electron transfer activity
GTHT12_RS14015	COG1024	Enoyl-CoA hydratase
GTHT12_RS14020	COG1309	transcriptional regulator
GTHT12_RS14025	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS14030	COG3766	membrane
GTHT12_RS14035	COG1193	negative regulation of DNA recombination
GTHT12_RS14040	COG1796	DNA polymerase
GTHT12_RS14040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTHT12_RS14045	COG1286	toxin biosynthetic process
GTHT12_RS14050	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GTHT12_RS14055	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTHT12_RS14065	COG2409	Drug exporters of the RND superfamily
GTHT12_RS14065	COG1033	growth of symbiont in host cell
GTHT12_RS14070	COG1846	Transcriptional regulator
GTHT12_RS14075	COG1785	Belongs to the alkaline phosphatase family
GTHT12_RS14080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTHT12_RS14085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTHT12_RS14090	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTHT12_RS14095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTHT12_RS14095	COG0072	phenylalanine-tRNA ligase activity
GTHT12_RS14100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTHT12_RS14105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTHT12_RS14110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTHT12_RS14125	COG1363	Peptidase, m42
GTHT12_RS14135	COG3326	Membrane
GTHT12_RS14140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTHT12_RS14145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTHT12_RS14155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTHT12_RS14165	COG1484	DNA-dependent DNA replication
GTHT12_RS14170	COG3611	Membrane attachment protein
GTHT12_RS14175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTHT12_RS14185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GTHT12_RS14190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTHT12_RS14195	COG0237	dephospho-CoA kinase activity
GTHT12_RS14200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTHT12_RS14210	COG5002	protein histidine kinase activity
GTHT12_RS14215	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS14225	COG0039	L-malate dehydrogenase activity
GTHT12_RS14230	COG0538	isocitrate dehydrogenase activity
GTHT12_RS14235	COG0372	Belongs to the citrate synthase family
GTHT12_RS14240	COG2707	UPF0756 membrane protein
GTHT12_RS14245	COG0628	permease
GTHT12_RS14260	COG0825	malonyl-CoA metabolic process
GTHT12_RS14265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GTHT12_RS14275	COG0587	DNA-directed DNA polymerase activity
GTHT12_RS14290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTHT12_RS14305	COG4109	DRTGG domain
GTHT12_RS14310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GTHT12_RS14315	COG0006	proline dipeptidase activity
GTHT12_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
GTHT12_RS14330	COG0589	response to stress
GTHT12_RS14335	COG0165	Argininosuccinate lyase
GTHT12_RS14340	COG0137	argininosuccinate synthase activity
GTHT12_RS14355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTHT12_RS14360	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTHT12_RS14365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTHT12_RS14370	COG0827	DNA restriction-modification system
GTHT12_RS14375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTHT12_RS14380	COG3874	Sporulation protein YtfJ
GTHT12_RS14390	COG1714	RDD family
GTHT12_RS14395	COG0616	signal peptide processing
GTHT12_RS14400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTHT12_RS14405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTHT12_RS14415	COG0301	tRNA thio-modification
GTHT12_RS14420	COG1104	cysteine desulfurase activity
GTHT12_RS14425	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GTHT12_RS14435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTHT12_RS14440	COG1956	GAF domain-containing protein
GTHT12_RS14445	COG2199	diguanylate cyclase activity
GTHT12_RS14445	COG2203	Gaf domain
GTHT12_RS14455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTHT12_RS14465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTHT12_RS14470	COG3328	transposase activity
GTHT12_RS14570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTHT12_RS14575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTHT12_RS14580	COG0454	-acetyltransferase
GTHT12_RS14585	COG0517	IMP dehydrogenase activity
GTHT12_RS14590	COG0123	including yeast histone deacetylase and acetoin utilization protein
GTHT12_RS14605	COG1605	Chorismate mutase
GTHT12_RS14605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GTHT12_RS14610	COG3118	belongs to the thioredoxin family
GTHT12_RS14625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTHT12_RS14630	COG1674	ftsk spoiiie
GTHT12_RS14630	COG1674	ftsk spoiiie
GTHT12_RS14635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTHT12_RS14640	COG4848	Belongs to the UPF0354 family
GTHT12_RS14645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GTHT12_RS14650	COG1363	Peptidase, m42
GTHT12_RS14660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTHT12_RS14665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GTHT12_RS14675	COG0510	thiamine kinase activity
GTHT12_RS14680	COG1523	belongs to the glycosyl hydrolase 13 family
GTHT12_RS14700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTHT12_RS14705	COG1349	DNA-binding transcription factor activity
GTHT12_RS14710	COG1187	pseudouridine synthase activity
GTHT12_RS14720	COG2244	polysaccharide biosynthetic process
GTHT12_RS14725	COG2081	HI0933 family
GTHT12_RS14735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTHT12_RS14740	COG0495	leucyl-tRNA aminoacylation
GTHT12_RS14745	COG2814	Major facilitator Superfamily
GTHT12_RS14760	COG1242	4 iron, 4 sulfur cluster binding
GTHT12_RS14765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GTHT12_RS14775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTHT12_RS14780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTHT12_RS14785	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTHT12_RS14795	COG1506	peptidase
GTHT12_RS14800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTHT12_RS14805	COG1116	anion transmembrane transporter activity
GTHT12_RS14810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTHT12_RS14815	COG0494	nUDIX hydrolase
GTHT12_RS14825	COG4824	toxin secretion phage lysis holin
GTHT12_RS14830	COG0783	Belongs to the Dps family
GTHT12_RS14840	COG1854	S-ribosylhomocysteine lyase activity
GTHT12_RS14845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GTHT12_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
GTHT12_RS14885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GTHT12_RS14890	COG0596	Alpha beta hydrolase
GTHT12_RS14895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GTHT12_RS14900	COG1169	isochorismate synthase
GTHT12_RS14905	COG1575	Belongs to the MenA family. Type 1 subfamily
GTHT12_RS14910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GTHT12_RS14920	COG0058	SHG alpha-glucan phosphorylase activity
GTHT12_RS14925	COG0297	glycogen (starch) synthase activity
GTHT12_RS14950	COG0427	acetyl-CoA hydrolase
GTHT12_RS14960	COG1280	lysine exporter protein (LysE YggA)
GTHT12_RS14980	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GTHT12_RS15030	COG2318	DinB family
GTHT12_RS15040	COG0346	lactoylglutathione lyase activity
GTHT12_RS15045	COG3328	transposase activity
GTHT12_RS15110	COG3328	transposase activity
GTHT12_RS15225	COG1285	pathogenesis
GTHT12_RS15240	COG1525	nuclease
GTHT12_RS15250	COG1247	-acetyltransferase
GTHT12_RS15260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTHT12_RS15270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTHT12_RS15280	COG0166	Belongs to the GPI family
GTHT12_RS15285	COG1979	alcohol dehydrogenase
GTHT12_RS15290	COG2155	Conserved Protein
GTHT12_RS15295	COG1098	S1 RNA binding domain
GTHT12_RS15300	COG0436	Aminotransferase
GTHT12_RS15305	COG1522	sequence-specific DNA binding
GTHT12_RS15315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GTHT12_RS15320	COG2032	superoxide dismutase activity
GTHT12_RS15330	COG5018	Exonuclease
GTHT12_RS15335	COG1320	monovalent cation:proton antiporter activity
GTHT12_RS15340	COG2212	antiporter activity
GTHT12_RS15345	COG1863	multisubunit Na H antiporter MnhE subunit
GTHT12_RS15350	COG0651	ATP synthesis coupled electron transport
GTHT12_RS15355	COG1006	Multisubunit Na H antiporter MnhC subunit
GTHT12_RS15360	COG2111	Na H antiporter
GTHT12_RS15365	COG2111	Na H antiporter
GTHT12_RS15365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTHT12_RS15380	COG0306	phosphate transporter
GTHT12_RS15385	COG1392	Phosphate transport regulator
GTHT12_RS15390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTHT12_RS15400	COG3584	3D domain protein
GTHT12_RS15415	COG1252	NADH dehydrogenase
GTHT12_RS15420	COG0492	ferredoxin-NADP+ reductase activity
GTHT12_RS15425	COG0316	Belongs to the HesB IscA family
GTHT12_RS15430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTHT12_RS15435	COG4844	belongs to the
GTHT12_RS15440	COG1252	NADH dehydrogenase
GTHT12_RS15445	COG4837	Protein of unknown function (DUF1462)
GTHT12_RS15450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GTHT12_RS15460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTHT12_RS15465	COG0460	homoserine dehydrogenase
GTHT12_RS15470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTHT12_RS15475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTHT12_RS15480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTHT12_RS15485	COG0647	UMP catabolic process
GTHT12_RS15490	COG2445	Protein of unknown function DUF86
GTHT12_RS15505	COG4470	Protein conserved in bacteria
GTHT12_RS15515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GTHT12_RS15520	COG0739	heme binding
GTHT12_RS15530	COG0411	ABC transporter
GTHT12_RS15555	COG3377	Domain of unknown function (DUF1805)
GTHT12_RS15560	COG0737	Belongs to the 5'-nucleotidase family
GTHT12_RS15565	COG0730	response to heat
GTHT12_RS15570	COG1801	Protein of unknown function DUF72
GTHT12_RS15580	COG0719	Fe-S assembly protein
GTHT12_RS15585	COG0822	iron-sulfur transferase activity
GTHT12_RS15590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTHT12_RS15595	COG0719	Fe-S assembly protein
GTHT12_RS15600	COG0396	ATPase activity
GTHT12_RS15605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTHT12_RS15615	COG1464	Belongs to the NlpA lipoprotein family
GTHT12_RS15620	COG2011	ABC-type metal ion transport system permease component
GTHT12_RS15625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTHT12_RS15635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTHT12_RS15640	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GTHT12_RS15650	COG0509	glycine decarboxylation via glycine cleavage system
GTHT12_RS15655	COG1393	Belongs to the ArsC family
GTHT12_RS15660	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS15665	COG0183	Belongs to the thiolase family
GTHT12_RS15670	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTHT12_RS15670	COG1024	Enoyl-CoA hydratase
GTHT12_RS15680	COG0506	proline dehydrogenase activity
GTHT12_RS15690	COG5577	PFAM Coat F domain
GTHT12_RS15715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTHT12_RS15720	COG0469	pyruvate kinase activity
GTHT12_RS15750	COG2358	TRAP transporter, solute receptor (TAXI family
GTHT12_RS15790	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS15810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTHT12_RS15825	COG0583	DNA-binding transcription factor activity
GTHT12_RS15830	COG3546	catalase activity
GTHT12_RS15850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTHT12_RS15855	COG0557	exoribonuclease II activity
GTHT12_RS15865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTHT12_RS15875	COG2272	Belongs to the type-B carboxylesterase lipase family
GTHT12_RS15880	COG0148	phosphopyruvate hydratase activity
GTHT12_RS15885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GTHT12_RS15890	COG0149	triose-phosphate isomerase activity
GTHT12_RS15895	COG0126	phosphoglycerate kinase activity
GTHT12_RS15915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GTHT12_RS15925	COG0740	serine-type endopeptidase activity
GTHT12_RS15930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTHT12_RS15935	COG1481	regulation of sporulation
GTHT12_RS15940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTHT12_RS15945	COG1660	Displays ATPase and GTPase activities
GTHT12_RS15950	COG1051	belongs to the nudix hydrolase family
GTHT12_RS15955	COG0492	ferredoxin-NADP+ reductase activity
GTHT12_RS15960	COG0457	Tetratricopeptide repeat
GTHT12_RS15970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GTHT12_RS15970	COG0140	phosphoribosyl-ATP diphosphatase activity
GTHT12_RS15975	COG0107	imidazoleglycerol-phosphate synthase activity
GTHT12_RS15980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GTHT12_RS15985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTHT12_RS15990	COG0131	Imidazoleglycerol-phosphate dehydratase
GTHT12_RS15995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GTHT12_RS16000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GTHT12_RS16005	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GTHT12_RS16010	COG0110	maltose O-acetyltransferase activity
GTHT12_RS16015	COG0546	phosphoglycolate phosphatase activity
GTHT12_RS16020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GTHT12_RS16025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTHT12_RS16030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GTHT12_RS16035	COG1950	PFAM Membrane protein of
GTHT12_RS16045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTHT12_RS16050	COG0556	nucleotide-excision repair
GTHT12_RS16060	COG4897	Protein conserved in bacteria
GTHT12_RS16065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTHT12_RS16070	COG0789	Transcriptional regulator
GTHT12_RS16075	COG3409	Peptidoglycan-binding domain 1 protein
GTHT12_RS16075	COG0793	Belongs to the peptidase S41A family
GTHT12_RS16080	COG1741	Belongs to the pirin family
GTHT12_RS16085	COG0739	heme binding
GTHT12_RS16090	COG2177	Part of the ABC transporter FtsEX involved in
GTHT12_RS16095	COG2884	Cell division ATP-binding protein ftsE
GTHT12_RS16105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTHT12_RS16115	COG0653	protein targeting
GTHT12_RS16140	COG1516	flagellar protein fliS
GTHT12_RS16145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GTHT12_RS16150	COG1334	flagellar protein FlaG
GTHT12_RS16180	COG3328	transposase activity
GTHT12_RS16195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTHT12_RS16210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTHT12_RS16215	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GTHT12_RS16225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTHT12_RS16230	COG1256	bacterial-type flagellum assembly
GTHT12_RS16230	COG4786	Flagellar basal body rod
GTHT12_RS16250	COG1728	Protein conserved in bacteria
GTHT12_RS16260	COG1516	flagellar protein fliS
GTHT12_RS16265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTHT12_RS16275	COG1040	competence protein
GTHT12_RS16280	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GTHT12_RS16285	COG1307	EDD domain protein, DegV family
GTHT12_RS16290	COG2197	response regulator
GTHT12_RS16295	COG4585	Histidine kinase
GTHT12_RS16300	COG1739	Uncharacterized protein family UPF0029
GTHT12_RS16305	COG1316	TRANSCRIPTIONal
GTHT12_RS16310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTHT12_RS16320	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS16335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTHT12_RS16340	COG1216	Glycosyl transferase, family 2
GTHT12_RS16340	COG1442	glycosyl transferase family 8
GTHT12_RS16345	COG0463	Glycosyl transferase, family 2
GTHT12_RS16345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTHT12_RS16350	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS16355	COG1134	teichoic acid transport
GTHT12_RS16360	COG1682	transport, permease protein
GTHT12_RS16365	COG3328	transposase activity
GTHT12_RS16375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTHT12_RS16385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GTHT12_RS16400	COG0728	peptidoglycan biosynthetic process
GTHT12_RS16405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTHT12_RS16410	COG1388	LysM domain
GTHT12_RS16410	COG0791	NLP P60 protein
GTHT12_RS16425	COG0629	single-stranded DNA binding
GTHT12_RS16435	COG3764	Sortase (surface protein transpeptidase)
GTHT12_RS16445	COG0527	aspartate kinase activity
GTHT12_RS16460	COG1012	belongs to the aldehyde dehydrogenase family
GTHT12_RS16470	COG0477	Major facilitator Superfamily
GTHT12_RS16475	COG1309	transcriptional regulator
GTHT12_RS16480	COG1940	carbohydrate kinase activity
GTHT12_RS16490	COG1175	transmembrane transport
GTHT12_RS16500	COG2207	Transcriptional regulator
GTHT12_RS16500	COG4753	response regulator
GTHT12_RS16505	COG2972	Histidine kinase
GTHT12_RS16530	COG1486	melibiose metabolic process
GTHT12_RS16540	COG2723	6-phospho-beta-galactosidase activity
GTHT12_RS16550	COG0277	FAD linked oxidase domain protein
GTHT12_RS16555	COG0022	dehydrogenase e1 component
GTHT12_RS16570	COG0346	lactoylglutathione lyase activity
GTHT12_RS16575	COG0673	inositol 2-dehydrogenase activity
GTHT12_RS16590	COG3328	transposase activity
GTHT12_RS16615	COG1671	Belongs to the UPF0178 family
GTHT12_RS16620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTHT12_RS16625	COG1309	transcriptional regulator
GTHT12_RS16630	COG3844	kynureninase activity
GTHT12_RS16635	COG0833	amino acid
GTHT12_RS16640	COG3483	tryptophan 2,3-dioxygenase activity
GTHT12_RS16645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GTHT12_RS16650	COG1879	ABC-type sugar transport system periplasmic component
GTHT12_RS16660	COG1129	ABC transporter
GTHT12_RS16665	COG1869	D-ribose catabolic process
GTHT12_RS16670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTHT12_RS16675	COG1609	Transcriptional regulator
GTHT12_RS16700	COG4948	Mandelate Racemase Muconate Lactonizing
GTHT12_RS16710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTHT12_RS16735	COG1114	Component of the transport system for branched-chain amino acids
GTHT12_RS16740	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTHT12_RS16745	COG3012	SEC-C Motif Domain Protein
GTHT12_RS16745	COG1405	negative regulation of cell septum assembly
GTHT12_RS16755	COG0653	protein targeting
GTHT12_RS16765	COG1405	negative regulation of cell septum assembly
GTHT12_RS16765	COG3012	SEC-C Motif Domain Protein
GTHT12_RS16770	COG1405	negative regulation of cell septum assembly
GTHT12_RS16770	COG3012	SEC-C Motif Domain Protein
GTHT12_RS16780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTHT12_RS16800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GTHT12_RS16810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTHT12_RS16815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTHT12_RS16820	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GTHT12_RS16830	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS16835	COG1175	transmembrane transport
GTHT12_RS16840	COG1653	transport
GTHT12_RS16850	COG0697	spore germination
GTHT12_RS16860	COG1376	ErfK ybiS ycfS ynhG family protein
GTHT12_RS16890	COG0383	alpha-mannosidase activity
GTHT12_RS16895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTHT12_RS16895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTHT12_RS16895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTHT12_RS16900	COG1737	Transcriptional regulator
GTHT12_RS16915	COG1349	DNA-binding transcription factor activity
GTHT12_RS16920	COG3395	kinase activity
GTHT12_RS16925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTHT12_RS16930	COG2610	gluconate transmembrane transporter activity
GTHT12_RS16940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTHT12_RS16945	COG1134	teichoic acid transport
GTHT12_RS16950	COG1682	transport, permease protein
GTHT12_RS16955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GTHT12_RS17030	COG1175	transmembrane transport
GTHT12_RS17070	COG0606	chelatase, subunit chli
GTHT12_RS17095	COG0717	Belongs to the dCTP deaminase family
GTHT12_RS17190	COG0443	Heat shock 70 kDa protein
GTHT12_RS17200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GTHT12_RS17210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTHT12_RS17215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTHT12_RS17225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GTHT12_RS17225	COG0662	Cupin 2, conserved barrel domain protein
GTHT12_RS17240	COG1045	serine acetyltransferase
GTHT12_RS17250	COG0438	transferase activity, transferring glycosyl groups
GTHT12_RS17275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GTHT12_RS17280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTHT12_RS17285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTHT12_RS17290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTHT12_RS17295	COG4464	protein tyrosine phosphatase activity
GTHT12_RS17300	COG1316	TRANSCRIPTIONal
GTHT12_RS17310	COG0489	protein tyrosine kinase activity
GTHT12_RS17315	COG3944	biosynthesis protein
GTHT12_RS17325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTHT12_RS17335	COG4786	Flagellar basal body rod
GTHT12_RS17340	COG4786	Flagellar basal body rod
GTHT12_RS17350	COG1609	Transcriptional regulator
GTHT12_RS17360	COG2059	Chromate
GTHT12_RS17365	COG2059	Chromate
GTHT12_RS17380	COG0444	Belongs to the ABC transporter superfamily
GTHT12_RS17385	COG1522	sequence-specific DNA binding
GTHT12_RS17390	COG0739	heme binding
GTHT12_RS17395	COG2385	sporulation resulting in formation of a cellular spore
GTHT12_RS17400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTHT12_RS17410	COG4836	Membrane
GTHT12_RS17415	COG1007	ATP synthesis coupled electron transport
GTHT12_RS17420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTHT12_RS17425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTHT12_RS17430	COG0713	ATP synthesis coupled electron transport
GTHT12_RS17435	COG0839	Belongs to the complex I subunit 6 family
GTHT12_RS17440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTHT12_RS17445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GTHT12_RS17450	COG0649	NAD binding
GTHT12_RS17455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTHT12_RS17460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTHT12_RS17465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTHT12_RS17470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTHT12_RS17475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTHT12_RS17480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTHT12_RS17485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTHT12_RS17490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTHT12_RS17495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTHT12_RS17500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTHT12_RS17505	COG0356	it plays a direct role in the translocation of protons across the membrane
GTHT12_RS17520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTHT12_RS17525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTHT12_RS17530	COG4475	Protein of unknown function (DUF436)
GTHT12_RS17535	COG0698	ribose 5-phosphate isomerase
GTHT12_RS17550	COG1971	Probably functions as a manganese efflux pump
GTHT12_RS17555	COG0009	L-threonylcarbamoyladenylate synthase
GTHT12_RS17565	COG2890	protein-(glutamine-N5) methyltransferase activity
GTHT12_RS17570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTHT12_RS17580	COG1435	thymidine kinase activity
GTHT12_RS17585	COG0254	rRNA binding
GTHT12_RS17590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GTHT12_RS17595	COG1494	fructose-1,6-bisphosphatase
GTHT12_RS17600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTHT12_RS17605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GTHT12_RS17615	COG2204	response regulator
GTHT12_RS17620	COG4821	SIS domain
GTHT12_RS17625	COG0504	CTP synthase activity
GTHT12_RS17630	COG3343	RNA polymerase activity
GTHT12_RS17635	COG1703	isobutyryl-CoA mutase activity
GTHT12_RS17635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GTHT12_RS17635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GTHT12_RS17645	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS17650	COG1960	acyl-CoA dehydrogenase activity
GTHT12_RS17655	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTHT12_RS17660	COG0183	Belongs to the thiolase family
GTHT12_RS17665	COG0247	lactate metabolic process
GTHT12_RS17665	COG2181	nitrate reductase activity
GTHT12_RS17670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTHT12_RS17680	COG0018	arginyl-trna synthetase
GTHT12_RS17700	COG0010	Belongs to the arginase family
GTHT12_RS17705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GTHT12_RS17710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTHT12_RS17720	COG1994	Peptidase M50
GTHT12_RS17725	COG1942	4-Oxalocrotonate Tautomerase
GTHT12_RS17730	COG2252	PERMEase
GTHT12_RS17735	COG3465	dGTPase activity
GTHT12_RS17740	COG1078	dGTPase activity
GTHT12_RS17745	COG4844	belongs to the
GTHT12_RS17755	COG0095	Lipoate-protein ligase
GTHT12_RS17765	COG0280	phosphate acetyltransferase
GTHT12_RS17770	COG3253	May function as heme-dependent peroxidase
GTHT12_RS17775	COG3773	Cell wall hydrolase
GTHT12_RS17790	COG1575	Belongs to the MenA family. Type 1 subfamily
GTHT12_RS17795	COG2363	Small membrane protein
GTHT12_RS17810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTHT12_RS17815	COG1366	Belongs to the anti-sigma-factor antagonist family
GTHT12_RS17820	COG2172	sigma factor antagonist activity
GTHT12_RS17825	COG1191	sigma factor activity
GTHT12_RS17830	COG2208	phosphoserine phosphatase activity
GTHT12_RS17835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GTHT12_RS17840	COG0423	glycine-tRNA ligase activity
GTHT12_RS17845	COG1216	Glycosyl transferase, family 2
GTHT12_RS17850	COG0477	Major facilitator Superfamily
GTHT12_RS17860	COG0473	3-isopropylmalate dehydrogenase activity
GTHT12_RS17865	COG2508	Transcriptional regulator
GTHT12_RS17865	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GTHT12_RS17870	COG0686	Belongs to the AlaDH PNT family
GTHT12_RS17875	COG0351	phosphomethylpyrimidine kinase
GTHT12_RS17880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTHT12_RS17890	COG0765	amino acid transport
GTHT12_RS17900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GTHT12_RS17910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTHT12_RS17920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTHT12_RS17925	COG1113	amino acid transport
GTHT12_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTHT12_RS17945	COG0723	plastoquinol--plastocyanin reductase activity
GTHT12_RS17950	COG1482	cell wall glycoprotein biosynthetic process
GTHT12_RS17960	COG1929	Belongs to the glycerate kinase type-1 family
GTHT12_RS17970	COG1846	Transcriptional regulator
GTHT12_RS17975	COG3328	transposase activity
GTHT12_RS18055	COG1131	(ABC) transporter
GTHT12_RS18065	COG2197	response regulator
GTHT12_RS18075	COG0494	nUDIX hydrolase
GTHT12_RS18090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTHT12_RS18100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTHT12_RS18105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GTHT12_RS18110	COG4853	Protein conserved in bacteria
GTHT12_RS18115	COG4863	YycH protein
GTHT12_RS18120	COG5002	protein histidine kinase activity
GTHT12_RS18125	COG0745	RESPONSE REGULATOR receiver
GTHT12_RS18130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GTHT12_RS18135	COG0305	Participates in initiation and elongation during chromosome replication
GTHT12_RS18140	COG0359	binds to the 23S rRNA
GTHT12_RS18145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GTHT12_RS18150	COG4241	membrane
GTHT12_RS18155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTHT12_RS18160	COG0629	single-stranded DNA binding
GTHT12_RS18165	COG0360	Binds together with S18 to 16S ribosomal RNA
GTHT12_RS18170	COG0012	GTP binding
GTHT12_RS18180	COG4481	Protein conserved in bacteria
GTHT12_RS18185	COG0668	transmembrane transport
GTHT12_RS18200	COG1475	DNA binding
GTHT12_RS18205	COG1192	Involved in chromosome partitioning
GTHT12_RS18210	COG1475	DNA binding
GTHT12_RS18215	COG0357	Ribosomal RNA small subunit methyltransferase G
GTHT12_RS18220	COG0445	tRNA wobble uridine modification
GTHT12_RS18225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTHT12_RS18230	COG1847	R3H domain protein
GTHT12_RS18235	COG0706	membrane insertase activity
GTHT12_RS18240	COG0594	ribonuclease P activity
GTHT12_RS18245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GTHT12_RS18270	COG0662	Cupin 2, conserved barrel domain protein
GTHT12_RS18350	COG0739	heme binding
GTHT12_RS18350	COG1196	nuclear chromosome segregation
GTHT12_RS18350	COG0741	lytic transglycosylase activity
GTHT12_RS18395	COG2003	Belongs to the UPF0758 family
GTHT12_RS18455	COG1051	belongs to the nudix hydrolase family
GTHT12_RS18490	COG1131	(ABC) transporter
GTHT12_RS18550	COG0658	competence protein
GTHT12_RS18550	COG2333	competence protein COMEC
GTHT12_RS18560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTHT12_RS18640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GTHT12_RS18665	COG1876	peptidase activity
GTHT12_RS18670	COG0582	viral genome integration into host DNA
GTHT12_RS18685	COG1525	nuclease
GTHT12_RS18690	COG1609	Transcriptional regulator
GTHT12_RS18695	COG4209	transmembrane transport
GTHT12_RS18700	COG0395	ABC-type sugar transport system, permease component
GTHT12_RS18710	COG1621	beta-fructofuranosidase activity
GTHT12_RS18715	COG1940	carbohydrate kinase activity
GTHT12_RS18720	COG4974	Belongs to the 'phage' integrase family
GTHT12_RS18825	COG1131	(ABC) transporter
GTHT12_RS18855	COG0658	competence protein
GTHT12_RS18855	COG2333	competence protein COMEC