locus-tag	class	description
GEOBRER4_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GEOBRER4_RS00015	COG0592	DNA-directed DNA polymerase activity
GEOBRER4_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GEOBRER4_RS00025	COG0187	DNA topoisomerase II activity
GEOBRER4_RS00040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GEOBRER4_RS00045	COG5002	protein histidine kinase activity
GEOBRER4_RS00055	COG3852	Histidine kinase
GEOBRER4_RS00075	COG0535	radical SAM domain protein
GEOBRER4_RS00080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GEOBRER4_RS00085	COG0598	Magnesium transport protein CorA
GEOBRER4_RS00090	COG4191	Histidine kinase
GEOBRER4_RS00095	COG2827	Endonuclease containing a URI domain
GEOBRER4_RS00105	COG0493	'glutamate synthase
GEOBRER4_RS00110	COG0543	2 iron, 2 sulfur cluster binding
GEOBRER4_RS00145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GEOBRER4_RS00160	COG1132	(ABC) transporter
GEOBRER4_RS00165	COG1132	(ABC) transporter
GEOBRER4_RS00190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GEOBRER4_RS00195	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS00210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GEOBRER4_RS00215	COG1845	cytochrome c oxidase, subunit III
GEOBRER4_RS00225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GEOBRER4_RS00230	COG0109	protoheme IX farnesyltransferase activity
GEOBRER4_RS00240	COG0156	8-amino-7-oxononanoate synthase activity
GEOBRER4_RS00245	COG1063	alcohol dehydrogenase
GEOBRER4_RS00265	COG2234	aminopeptidase activity
GEOBRER4_RS00275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GEOBRER4_RS00285	COG2132	Multicopper oxidase
GEOBRER4_RS00285	COG2132	Multicopper oxidase
GEOBRER4_RS00310	COG2267	carboxylic ester hydrolase activity
GEOBRER4_RS00315	COG0436	Aminotransferase
GEOBRER4_RS00325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS00330	COG0482	sulfurtransferase activity
GEOBRER4_RS00335	COG5001	Diguanylate cyclase
GEOBRER4_RS00335	COG3300	MHYT domain
GEOBRER4_RS00345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GEOBRER4_RS00350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GEOBRER4_RS00365	COG0784	Response regulator, receiver
GEOBRER4_RS00380	COG0784	Response regulator, receiver
GEOBRER4_RS00380	COG2205	protein histidine kinase activity
GEOBRER4_RS00390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GEOBRER4_RS00400	COG2814	Major facilitator Superfamily
GEOBRER4_RS00405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GEOBRER4_RS00420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GEOBRER4_RS00425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GEOBRER4_RS00455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GEOBRER4_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GEOBRER4_RS00480	COG1047	Peptidyl-prolyl cis-trans
GEOBRER4_RS00495	COG3132	Protein of unknown function, DUF480
GEOBRER4_RS00515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GEOBRER4_RS00520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GEOBRER4_RS00555	COG4771	TonB-dependent receptor
GEOBRER4_RS00575	COG2326	polyphosphate kinase activity
GEOBRER4_RS00620	COG0366	Alpha amylase catalytic
GEOBRER4_RS00635	COG1295	ribonuclease BN
GEOBRER4_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS00655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GEOBRER4_RS00685	COG2204	response regulator
GEOBRER4_RS00690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS00695	COG0784	Response regulator, receiver
GEOBRER4_RS00700	COG0556	nucleotide-excision repair
GEOBRER4_RS00720	COG0450	alkyl hydroperoxide reductase
GEOBRER4_RS00750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GEOBRER4_RS00760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GEOBRER4_RS00765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GEOBRER4_RS00770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GEOBRER4_RS00780	COG1007	ATP synthesis coupled electron transport
GEOBRER4_RS00790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GEOBRER4_RS00795	COG0713	ATP synthesis coupled electron transport
GEOBRER4_RS00805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS00815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GEOBRER4_RS00820	COG1034	ATP synthesis coupled electron transport
GEOBRER4_RS00825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GEOBRER4_RS00835	COG0649	NAD binding
GEOBRER4_RS00835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS00835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS00840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS00850	COG0604	alcohol dehydrogenase
GEOBRER4_RS00855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GEOBRER4_RS00870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GEOBRER4_RS00875	COG0426	domain, Protein
GEOBRER4_RS00880	COG0513	Belongs to the DEAD box helicase family
GEOBRER4_RS00895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GEOBRER4_RS00910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GEOBRER4_RS00915	COG3132	Protein of unknown function, DUF480
GEOBRER4_RS00920	COG0741	lytic transglycosylase activity
GEOBRER4_RS00955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GEOBRER4_RS00970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GEOBRER4_RS00985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GEOBRER4_RS00995	COG1278	Cold shock
GEOBRER4_RS01000	COG1013	pyruvate-flavodoxin oxidoreductase activity
GEOBRER4_RS01000	COG0674	pyruvate-flavodoxin oxidoreductase activity
GEOBRER4_RS01000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GEOBRER4_RS01000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GEOBRER4_RS01005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GEOBRER4_RS01010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GEOBRER4_RS01015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GEOBRER4_RS01040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GEOBRER4_RS01045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GEOBRER4_RS01050	COG0484	heat shock protein binding
GEOBRER4_RS01070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GEOBRER4_RS01075	COG3290	protein histidine kinase activity
GEOBRER4_RS01075	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS01080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GEOBRER4_RS01085	COG3576	pyridoxamine 5-phosphate
GEOBRER4_RS01090	COG1560	Kdo2-lipid A biosynthetic process
GEOBRER4_RS01105	COG1584	GPR1 FUN34 yaaH family protein
GEOBRER4_RS01110	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS01140	COG1104	cysteine desulfurase activity
GEOBRER4_RS01145	COG0583	DNA-binding transcription factor activity
GEOBRER4_RS01160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GEOBRER4_RS01165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GEOBRER4_RS01170	COG0163	prenyltransferase activity
GEOBRER4_RS01175	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GEOBRER4_RS01180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GEOBRER4_RS01185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GEOBRER4_RS01205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GEOBRER4_RS01210	COG2264	protein methyltransferase activity
GEOBRER4_RS01215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GEOBRER4_RS01220	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GEOBRER4_RS01230	COG1234	tRNA 3'-trailer cleavage
GEOBRER4_RS01250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GEOBRER4_RS01255	COG0459	protein refolding
GEOBRER4_RS01285	COG2719	SpoVR family
GEOBRER4_RS01305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GEOBRER4_RS01310	COG0045	succinate-CoA ligase (ADP-forming) activity
GEOBRER4_RS01325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GEOBRER4_RS01330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GEOBRER4_RS01335	COG1796	DNA polymerase
GEOBRER4_RS01335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GEOBRER4_RS01350	COG0598	Magnesium transport protein CorA
GEOBRER4_RS01355	COG0308	aminopeptidase N
GEOBRER4_RS01370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GEOBRER4_RS01380	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GEOBRER4_RS01385	COG1811	Na channel or pump
GEOBRER4_RS01390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GEOBRER4_RS01400	COG1410	methionine synthase
GEOBRER4_RS01400	COG0646	methionine synthase
GEOBRER4_RS01410	COG3959	Transketolase, thiamine diphosphate binding domain
GEOBRER4_RS01415	COG3958	Transketolase
GEOBRER4_RS01425	COG4191	Histidine kinase
GEOBRER4_RS01430	COG2204	response regulator
GEOBRER4_RS01450	COG0038	chloride channel
GEOBRER4_RS01465	COG2885	chlorophyll binding
GEOBRER4_RS01475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS01500	COG1733	regulation of RNA biosynthetic process
GEOBRER4_RS01520	COG0204	Acyl-transferase
GEOBRER4_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
GEOBRER4_RS01530	COG3047	cAMP biosynthetic process
GEOBRER4_RS01530	COG2885	chlorophyll binding
GEOBRER4_RS01570	COG5002	protein histidine kinase activity
GEOBRER4_RS01605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GEOBRER4_RS01620	COG0321	lipoyl(octanoyl) transferase activity
GEOBRER4_RS01620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GEOBRER4_RS01650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GEOBRER4_RS01655	COG1074	ATP-dependent DNA helicase activity
GEOBRER4_RS01660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GEOBRER4_RS01675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GEOBRER4_RS01680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GEOBRER4_RS01690	COG2084	Dehydrogenase
GEOBRER4_RS01710	COG1490	D-aminoacyl-tRNA deacylase activity
GEOBRER4_RS01720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GEOBRER4_RS01740	COG1959	2 iron, 2 sulfur cluster binding
GEOBRER4_RS01745	COG1606	tRNA processing
GEOBRER4_RS01750	COG0071	Belongs to the small heat shock protein (HSP20) family
GEOBRER4_RS01765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GEOBRER4_RS01765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GEOBRER4_RS01780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS01785	COG2840	Smr protein MutS2
GEOBRER4_RS01790	COG1940	carbohydrate kinase activity
GEOBRER4_RS01800	COG0011	TIGRFAM Protein of
GEOBRER4_RS01805	COG0702	epimerase
GEOBRER4_RS01810	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS01835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GEOBRER4_RS01850	COG3657	addiction module killer protein
GEOBRER4_RS01905	COG1970	mechanosensitive ion channel activity
GEOBRER4_RS01945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GEOBRER4_RS01950	COG0509	glycine decarboxylation via glycine cleavage system
GEOBRER4_RS01955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GEOBRER4_RS01965	COG0095	Lipoate-protein ligase
GEOBRER4_RS01975	COG5002	protein histidine kinase activity
GEOBRER4_RS01975	COG3850	Histidine kinase
GEOBRER4_RS01995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GEOBRER4_RS02000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GEOBRER4_RS02005	COG3118	belongs to the thioredoxin family
GEOBRER4_RS02010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GEOBRER4_RS02010	COG1648	precorrin-2 dehydrogenase activity
GEOBRER4_RS02015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GEOBRER4_RS02020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GEOBRER4_RS02025	COG0181	hydroxymethylbilane synthase activity
GEOBRER4_RS02035	COG0113	porphobilinogen synthase activity
GEOBRER4_RS02050	COG0023	Translation Initiation Factor
GEOBRER4_RS02060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GEOBRER4_RS02070	COG0582	viral genome integration into host DNA
GEOBRER4_RS02100	COG1061	Type III restriction enzyme res subunit
GEOBRER4_RS02125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GEOBRER4_RS02135	COG1696	Membrane protein involved in D-alanine export
GEOBRER4_RS02145	COG5001	Diguanylate cyclase
GEOBRER4_RS02145	COG5002	protein histidine kinase activity
GEOBRER4_RS02145	COG3447	MASE1 domain protein
GEOBRER4_RS02175	COG2095	MarC family integral membrane protein
GEOBRER4_RS02185	COG1116	anion transmembrane transporter activity
GEOBRER4_RS02195	COG3604	Transcriptional regulator
GEOBRER4_RS02210	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS02215	COG1136	(ABC) transporter
GEOBRER4_RS02220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GEOBRER4_RS02255	COG4783	chaperone-mediated protein folding
GEOBRER4_RS02265	COG4585	Histidine kinase
GEOBRER4_RS02270	COG2197	response regulator
GEOBRER4_RS02300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GEOBRER4_RS02315	COG0022	dehydrogenase e1 component
GEOBRER4_RS02325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GEOBRER4_RS02335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GEOBRER4_RS02340	COG2233	PERMEase
GEOBRER4_RS02360	COG0427	acetyl-CoA hydrolase
GEOBRER4_RS02370	COG4974	Belongs to the 'phage' integrase family
GEOBRER4_RS02375	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GEOBRER4_RS02390	COG1217	gtp-binding protein TYPA
GEOBRER4_RS02405	COG0116	Belongs to the methyltransferase superfamily
GEOBRER4_RS02415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GEOBRER4_RS02440	COG2001	Belongs to the MraZ family
GEOBRER4_RS02445	COG0275	rRNA processing
GEOBRER4_RS02450	COG3116	cell division
GEOBRER4_RS02460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GEOBRER4_RS02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GEOBRER4_RS02470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GEOBRER4_RS02475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GEOBRER4_RS02480	COG0772	Belongs to the SEDS family
GEOBRER4_RS02485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GEOBRER4_RS02490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GEOBRER4_RS02495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GEOBRER4_RS02500	COG1181	Belongs to the D-alanine--D-alanine ligase family
GEOBRER4_RS02505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GEOBRER4_RS02515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GEOBRER4_RS02525	COG0587	DNA-directed DNA polymerase activity
GEOBRER4_RS02530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GEOBRER4_RS02535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GEOBRER4_RS02560	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS02590	COG2204	response regulator
GEOBRER4_RS02595	COG5002	protein histidine kinase activity
GEOBRER4_RS02670	COG3437	response regulator, receiver
GEOBRER4_RS02690	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS02690	COG3290	protein histidine kinase activity
GEOBRER4_RS02700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GEOBRER4_RS02710	COG4566	intracellular signal transduction
GEOBRER4_RS02710	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS02725	COG3259	Nickel-dependent hydrogenase
GEOBRER4_RS02730	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GEOBRER4_RS02735	COG2878	Part of a membrane complex involved in electron transport
GEOBRER4_RS02765	COG2252	PERMEase
GEOBRER4_RS02770	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GEOBRER4_RS02775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GEOBRER4_RS02780	COG1960	acyl-CoA dehydrogenase activity
GEOBRER4_RS02800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GEOBRER4_RS02805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GEOBRER4_RS02815	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GEOBRER4_RS02850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GEOBRER4_RS02855	COG0124	histidyl-tRNA synthetase
GEOBRER4_RS02880	COG0346	lactoylglutathione lyase activity
GEOBRER4_RS02885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS02885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS02895	COG0439	Biotin carboxylase
GEOBRER4_RS02900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GEOBRER4_RS02910	COG0277	FAD linked oxidase domain protein
GEOBRER4_RS02915	COG3875	lactate racemase activity
GEOBRER4_RS02920	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GEOBRER4_RS02925	COG0297	glycogen (starch) synthase activity
GEOBRER4_RS02930	COG0501	Belongs to the peptidase M48B family
GEOBRER4_RS02940	COG0542	response to heat
GEOBRER4_RS02950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GEOBRER4_RS02955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GEOBRER4_RS02960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GEOBRER4_RS02990	COG0768	penicillin binding
GEOBRER4_RS02995	COG1295	ribonuclease BN
GEOBRER4_RS03040	COG2165	general secretion pathway protein
GEOBRER4_RS03075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GEOBRER4_RS03080	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GEOBRER4_RS03085	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS03085	COG4191	Histidine kinase
GEOBRER4_RS03085	COG2205	protein histidine kinase activity
GEOBRER4_RS03105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GEOBRER4_RS03115	COG0432	Pfam Uncharacterised protein family UPF0047
GEOBRER4_RS03125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GEOBRER4_RS03135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GEOBRER4_RS03140	COG0586	Pfam SNARE associated Golgi protein
GEOBRER4_RS03150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GEOBRER4_RS03150	COG0646	methionine synthase
GEOBRER4_RS03155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GEOBRER4_RS03160	COG0037	tRNA processing
GEOBRER4_RS03165	COG0348	domain, Protein
GEOBRER4_RS03175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GEOBRER4_RS03180	COG1666	GTP binding
GEOBRER4_RS03195	COG2198	Histidine kinase
GEOBRER4_RS03195	COG0643	Histidine kinase
GEOBRER4_RS03200	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS03210	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS03215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GEOBRER4_RS03220	COG0436	Aminotransferase
GEOBRER4_RS03235	COG0604	alcohol dehydrogenase
GEOBRER4_RS03235	COG3321	synthase
GEOBRER4_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS03260	COG0242	peptide deformylase activity
GEOBRER4_RS03265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GEOBRER4_RS03285	COG3437	response regulator, receiver
GEOBRER4_RS03285	COG0784	Response regulator, receiver
GEOBRER4_RS03295	COG0752	glycyl-tRNA synthetase alpha subunit
GEOBRER4_RS03300	COG0751	glycine-tRNA ligase activity
GEOBRER4_RS03305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GEOBRER4_RS03305	COG0574	Belongs to the PEP-utilizing enzyme family
GEOBRER4_RS03310	COG1278	Cold shock
GEOBRER4_RS03325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GEOBRER4_RS03335	COG0179	Fumarylacetoacetate (FAA) hydrolase
GEOBRER4_RS03340	COG1242	4 iron, 4 sulfur cluster binding
GEOBRER4_RS03345	COG0352	thiamine-phosphate diphosphorylase activity
GEOBRER4_RS03350	COG2022	thiamine diphosphate biosynthetic process
GEOBRER4_RS03360	COG4191	Histidine kinase
GEOBRER4_RS03365	COG1414	Transcriptional regulator
GEOBRER4_RS03370	COG0237	dephospho-CoA kinase activity
GEOBRER4_RS03405	COG5557	Pfam Polysulphide reductase, NrfD
GEOBRER4_RS03410	COG3064	Membrane
GEOBRER4_RS03410	COG0437	4 iron, 4 sulfur cluster binding
GEOBRER4_RS03450	COG2204	response regulator
GEOBRER4_RS03485	COG2985	domain, Protein
GEOBRER4_RS03485	COG0569	domain protein
GEOBRER4_RS03500	COG0784	Response regulator, receiver
GEOBRER4_RS03505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GEOBRER4_RS03515	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS03530	COG0612	Peptidase, M16
GEOBRER4_RS03535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GEOBRER4_RS03540	COG0488	(ABC) transporter
GEOBRER4_RS03545	COG1403	HNH endonuclease
GEOBRER4_RS03555	COG0697	spore germination
GEOBRER4_RS03590	COG1530	ribonuclease E activity
GEOBRER4_RS03595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GEOBRER4_RS03600	COG1993	acr, cog1993
GEOBRER4_RS03605	COG0567	Dehydrogenase, E1 component
GEOBRER4_RS03610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GEOBRER4_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GEOBRER4_RS03620	COG0321	lipoyl(octanoyl) transferase activity
GEOBRER4_RS03625	COG1067	ATP-dependent peptidase activity
GEOBRER4_RS03630	COG1597	lipid kinase activity
GEOBRER4_RS03640	COG0463	Glycosyl transferase, family 2
GEOBRER4_RS03645	COG0835	chemotaxis
GEOBRER4_RS03645	COG0784	Response regulator, receiver
GEOBRER4_RS03650	COG0243	molybdopterin cofactor binding
GEOBRER4_RS03660	COG2059	Chromate
GEOBRER4_RS03675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GEOBRER4_RS03705	COG4120	Belongs to the binding-protein-dependent transport system permease family
GEOBRER4_RS03715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GEOBRER4_RS03750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GEOBRER4_RS03755	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GEOBRER4_RS03770	COG1160	GTP binding
GEOBRER4_RS03780	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS03785	COG2198	Histidine kinase
GEOBRER4_RS03785	COG0643	Histidine kinase
GEOBRER4_RS03790	COG3409	Peptidoglycan-binding domain 1 protein
GEOBRER4_RS03790	COG3267	Type II secretory pathway component ExeA
GEOBRER4_RS03795	COG0835	chemotaxis
GEOBRER4_RS03805	COG0835	chemotaxis
GEOBRER4_RS03810	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS03820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GEOBRER4_RS03825	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS03835	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS03845	COG0495	leucyl-tRNA aminoacylation
GEOBRER4_RS03855	COG1466	dna polymerase III delta subunit
GEOBRER4_RS03860	COG0268	Binds directly to 16S ribosomal RNA
GEOBRER4_RS03890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GEOBRER4_RS03900	COG1363	Peptidase, m42
GEOBRER4_RS03905	COG0517	IMP dehydrogenase activity
GEOBRER4_RS03905	COG0516	GMP reductase activity
GEOBRER4_RS03910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GEOBRER4_RS03910	COG0519	Catalyzes the synthesis of GMP from XMP
GEOBRER4_RS03930	COG2985	domain, Protein
GEOBRER4_RS03930	COG0569	domain protein
GEOBRER4_RS03990	COG1136	(ABC) transporter
GEOBRER4_RS04010	COG1309	transcriptional regulator
GEOBRER4_RS04035	COG1802	Transcriptional regulator
GEOBRER4_RS04040	COG0427	acetyl-CoA hydrolase
GEOBRER4_RS04065	COG3437	response regulator, receiver
GEOBRER4_RS04070	COG0784	Response regulator, receiver
GEOBRER4_RS04070	COG5002	protein histidine kinase activity
GEOBRER4_RS04125	COG1215	transferase activity, transferring glycosyl groups
GEOBRER4_RS04130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GEOBRER4_RS04175	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS04185	COG4783	chaperone-mediated protein folding
GEOBRER4_RS04190	COG2195	Cleaves the N-terminal amino acid of tripeptides
GEOBRER4_RS04200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GEOBRER4_RS04220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GEOBRER4_RS04260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GEOBRER4_RS04265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GEOBRER4_RS04300	COG0791	NLP P60 protein
GEOBRER4_RS04300	COG1388	LysM domain
GEOBRER4_RS04325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GEOBRER4_RS04330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GEOBRER4_RS04335	COG1657	PFAM Prenyltransferase squalene oxidase
GEOBRER4_RS04345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GEOBRER4_RS04360	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GEOBRER4_RS04385	COG0159	tryptophan synthase activity
GEOBRER4_RS04390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GEOBRER4_RS04395	COG0285	dihydrofolate synthase activity
GEOBRER4_RS04400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GEOBRER4_RS04410	COG1091	dTDP-4-dehydrorhamnose reductase activity
GEOBRER4_RS04420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GEOBRER4_RS04450	COG3956	TIGRFAM MazG family protein
GEOBRER4_RS04460	COG0343	queuine tRNA-ribosyltransferase activity
GEOBRER4_RS04475	COG1053	succinate dehydrogenase
GEOBRER4_RS04500	COG2116	formate transmembrane transporter activity
GEOBRER4_RS04510	COG4251	negative regulation of phosphorylation
GEOBRER4_RS04525	COG3932	Exopolysaccharide synthesis, ExoD
GEOBRER4_RS04590	COG2255	four-way junction helicase activity
GEOBRER4_RS04595	COG0632	four-way junction helicase activity
GEOBRER4_RS04600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GEOBRER4_RS04605	COG0217	transcriptional regulatory protein
GEOBRER4_RS04615	COG3321	synthase
GEOBRER4_RS04615	COG0604	alcohol dehydrogenase
GEOBRER4_RS04625	COG0463	Glycosyl transferase, family 2
GEOBRER4_RS04650	COG1032	radical SAM domain protein
GEOBRER4_RS04655	COG0488	(ABC) transporter
GEOBRER4_RS04660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GEOBRER4_RS04670	COG0517	IMP dehydrogenase activity
GEOBRER4_RS04680	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS04685	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS04690	COG2205	protein histidine kinase activity
GEOBRER4_RS04700	COG0513	Belongs to the DEAD box helicase family
GEOBRER4_RS04705	COG2033	superoxide reductase activity
GEOBRER4_RS04720	COG3012	SEC-C Motif Domain Protein
GEOBRER4_RS04725	COG2873	o-acetylhomoserine
GEOBRER4_RS04730	COG0436	Aminotransferase
GEOBRER4_RS04735	COG2204	response regulator
GEOBRER4_RS04745	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GEOBRER4_RS04755	COG1253	flavin adenine dinucleotide binding
GEOBRER4_RS04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GEOBRER4_RS04780	COG1131	(ABC) transporter
GEOBRER4_RS04785	COG1131	(ABC) transporter
GEOBRER4_RS04790	COG4999	Histidine kinase
GEOBRER4_RS04790	COG3850	Histidine kinase
GEOBRER4_RS04790	COG2205	protein histidine kinase activity
GEOBRER4_RS04790	COG3437	response regulator, receiver
GEOBRER4_RS04795	COG0784	Response regulator, receiver
GEOBRER4_RS04795	COG2198	Histidine kinase
GEOBRER4_RS04795	COG2205	protein histidine kinase activity
GEOBRER4_RS04800	COG0842	Transport permease protein
GEOBRER4_RS04805	COG0842	Transport permease protein
GEOBRER4_RS04810	COG2816	NAD+ diphosphatase activity
GEOBRER4_RS04820	COG0482	sulfurtransferase activity
GEOBRER4_RS04830	COG1550	Protein conserved in bacteria
GEOBRER4_RS04835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GEOBRER4_RS04840	COG1136	(ABC) transporter
GEOBRER4_RS04845	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS04850	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS04860	COG1605	Chorismate mutase
GEOBRER4_RS04860	COG0077	Prephenate dehydratase
GEOBRER4_RS04870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GEOBRER4_RS04875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GEOBRER4_RS04880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GEOBRER4_RS04885	COG0539	negative regulation of cytoplasmic translation
GEOBRER4_RS04890	COG0776	regulation of translation
GEOBRER4_RS04900	COG0582	viral genome integration into host DNA
GEOBRER4_RS04960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GEOBRER4_RS04985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GEOBRER4_RS05000	COG2181	nitrate reductase activity
GEOBRER4_RS05000	COG0247	lactate metabolic process
GEOBRER4_RS05005	COG4191	Histidine kinase
GEOBRER4_RS05005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS05010	COG2204	response regulator
GEOBRER4_RS05015	COG1301	dicarboxylic acid transport
GEOBRER4_RS05020	COG0045	succinate-CoA ligase (ADP-forming) activity
GEOBRER4_RS05025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GEOBRER4_RS05040	COG2234	aminopeptidase activity
GEOBRER4_RS05065	COG1561	YicC-like family, N-terminal region
GEOBRER4_RS05070	COG0194	GDP metabolic process
GEOBRER4_RS05075	COG1758	RNA polymerase activity
GEOBRER4_RS05090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GEOBRER4_RS05100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GEOBRER4_RS05100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GEOBRER4_RS05105	COG1774	PSP1 C-terminal conserved region
GEOBRER4_RS05110	COG0470	DNA polymerase III
GEOBRER4_RS05115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GEOBRER4_RS05120	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS05125	COG0571	ribonuclease III activity
GEOBRER4_RS05135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GEOBRER4_RS05140	COG3005	denitrification pathway
GEOBRER4_RS05150	COG0651	ATP synthesis coupled electron transport
GEOBRER4_RS05170	COG0651	ATP synthesis coupled electron transport
GEOBRER4_RS05185	COG0651	ATP synthesis coupled electron transport
GEOBRER4_RS05190	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GEOBRER4_RS05190	COG3261	NADH dehydrogenase
GEOBRER4_RS05195	COG3260	NADH ubiquinone oxidoreductase 20
GEOBRER4_RS05205	COG1278	Cold shock
GEOBRER4_RS05225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GEOBRER4_RS05230	COG3876	Protein conserved in bacteria
GEOBRER4_RS05245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GEOBRER4_RS05255	COG0729	surface antigen
GEOBRER4_RS05300	COG0746	molybdenum cofactor guanylyltransferase activity
GEOBRER4_RS05325	COG0835	chemotaxis
GEOBRER4_RS05335	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS05370	COG1162	GTPase activity
GEOBRER4_RS05400	COG0375	protein maturation
GEOBRER4_RS05405	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GEOBRER4_RS05410	COG0437	4 iron, 4 sulfur cluster binding
GEOBRER4_RS05415	COG5557	Pfam Polysulphide reductase, NrfD
GEOBRER4_RS05420	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GEOBRER4_RS05425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GEOBRER4_RS05430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS05440	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GEOBRER4_RS05445	COG0298	carbon dioxide binding
GEOBRER4_RS05450	COG0409	Hydrogenase expression formation protein
GEOBRER4_RS05455	COG0309	Hydrogenase expression formation protein (HypE)
GEOBRER4_RS05465	COG2197	response regulator
GEOBRER4_RS05470	COG0004	ammonium transporteR
GEOBRER4_RS05475	COG0123	including yeast histone deacetylase and acetoin utilization protein
GEOBRER4_RS05495	COG1832	CoA-binding protein
GEOBRER4_RS05505	COG1127	ABC transporter
GEOBRER4_RS05540	COG0616	signal peptide processing
GEOBRER4_RS05550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GEOBRER4_RS05555	COG0416	fatty acid biosynthetic process
GEOBRER4_RS05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GEOBRER4_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS05575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GEOBRER4_RS05580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GEOBRER4_RS05585	COG0698	ribose 5-phosphate isomerase
GEOBRER4_RS05590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GEOBRER4_RS05610	COG0658	competence protein
GEOBRER4_RS05610	COG2333	competence protein COMEC
GEOBRER4_RS05615	COG3706	GGDEF domain
GEOBRER4_RS05620	COG0124	histidyl-tRNA synthetase
GEOBRER4_RS05625	COG1741	Belongs to the pirin family
GEOBRER4_RS05640	COG0587	DNA-directed DNA polymerase activity
GEOBRER4_RS05645	COG0825	malonyl-CoA metabolic process
GEOBRER4_RS05650	COG2733	membrane
GEOBRER4_RS05655	COG1187	pseudouridine synthase activity
GEOBRER4_RS05695	COG0671	phosphoesterase, PA-phosphatase related
GEOBRER4_RS05705	COG1643	Atp-dependent helicase
GEOBRER4_RS05710	COG0739	heme binding
GEOBRER4_RS05725	COG0174	glutamine synthetase
GEOBRER4_RS05745	COG3123	guanosine phosphorylase activity
GEOBRER4_RS05750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GEOBRER4_RS05760	COG1607	acyl-coa hydrolase
GEOBRER4_RS05800	COG3383	formate dehydrogenase (NAD+) activity
GEOBRER4_RS05810	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GEOBRER4_RS05815	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GEOBRER4_RS05830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GEOBRER4_RS05835	COG4149	molybdate abc transporter
GEOBRER4_RS05840	COG0725	ABC transporter, periplasmic molybdate-binding protein
GEOBRER4_RS05845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GEOBRER4_RS05850	COG3437	response regulator, receiver
GEOBRER4_RS05850	COG4999	Histidine kinase
GEOBRER4_RS05850	COG3850	Histidine kinase
GEOBRER4_RS05850	COG2205	protein histidine kinase activity
GEOBRER4_RS05855	COG1763	Mo-molybdopterin cofactor biosynthetic process
GEOBRER4_RS05860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS05970	COG2183	response to ionizing radiation
GEOBRER4_RS05975	COG2131	deaminase
GEOBRER4_RS05980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GEOBRER4_RS05995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GEOBRER4_RS05995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GEOBRER4_RS06000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GEOBRER4_RS06005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GEOBRER4_RS06045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GEOBRER4_RS06050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GEOBRER4_RS06055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GEOBRER4_RS06060	COG0402	S-adenosylhomocysteine deaminase activity
GEOBRER4_RS06110	COG1215	transferase activity, transferring glycosyl groups
GEOBRER4_RS06130	COG0398	Pfam SNARE associated Golgi protein
GEOBRER4_RS06140	COG2897	thiosulfate sulfurtransferase activity
GEOBRER4_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS06265	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS06270	COG5002	protein histidine kinase activity
GEOBRER4_RS06275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GEOBRER4_RS06280	COG0569	domain protein
GEOBRER4_RS06310	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GEOBRER4_RS06315	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS06315	COG3290	protein histidine kinase activity
GEOBRER4_RS06325	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS06325	COG3290	protein histidine kinase activity
GEOBRER4_RS06350	COG2198	Histidine kinase
GEOBRER4_RS06350	COG0643	Histidine kinase
GEOBRER4_RS06380	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS06405	COG1064	alcohol dehydrogenase
GEOBRER4_RS06420	COG3706	GGDEF domain
GEOBRER4_RS06425	COG3604	Transcriptional regulator
GEOBRER4_RS06430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GEOBRER4_RS06450	COG1331	Highly conserved protein containing a thioredoxin domain
GEOBRER4_RS06465	COG4191	Histidine kinase
GEOBRER4_RS06465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS06475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GEOBRER4_RS06480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GEOBRER4_RS06500	COG1166	arginine decarboxylase activity
GEOBRER4_RS06515	COG2353	YceI-like domain
GEOBRER4_RS06525	COG1139	Iron-sulfur cluster binding protein
GEOBRER4_RS06535	COG1620	l-lactate permease
GEOBRER4_RS06540	COG1380	Effector of murein hydrolase LrgA
GEOBRER4_RS06545	COG1346	cytolysis
GEOBRER4_RS06550	COG0277	FAD linked oxidase domain protein
GEOBRER4_RS06560	COG2186	Transcriptional regulator
GEOBRER4_RS06565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GEOBRER4_RS06580	COG0039	L-malate dehydrogenase activity
GEOBRER4_RS06590	COG0674	pyruvate-flavodoxin oxidoreductase activity
GEOBRER4_RS06590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GEOBRER4_RS06595	COG1013	pyruvate-flavodoxin oxidoreductase activity
GEOBRER4_RS06605	COG3437	response regulator, receiver
GEOBRER4_RS06605	COG2770	Histidine kinase
GEOBRER4_RS06610	COG0617	tRNA 3'-terminal CCA addition
GEOBRER4_RS06615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GEOBRER4_RS06620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GEOBRER4_RS06625	COG0442	prolyl-tRNA aminoacylation
GEOBRER4_RS06630	COG0284	orotidine-5'-phosphate decarboxylase activity
GEOBRER4_RS06635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GEOBRER4_RS06665	COG1476	TRANSCRIPTIONal
GEOBRER4_RS06695	COG2885	chlorophyll binding
GEOBRER4_RS06705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GEOBRER4_RS06720	COG1846	Transcriptional regulator
GEOBRER4_RS06745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GEOBRER4_RS06760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GEOBRER4_RS06850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GEOBRER4_RS06865	COG0697	spore germination
GEOBRER4_RS06870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GEOBRER4_RS06900	COG0493	'glutamate synthase
GEOBRER4_RS06905	COG0067	glutamate synthase
GEOBRER4_RS06905	COG0070	glutamate synthase
GEOBRER4_RS06905	COG0069	glutamate synthase activity
GEOBRER4_RS06955	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS06965	COG1597	lipid kinase activity
GEOBRER4_RS06970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GEOBRER4_RS06975	COG2832	Protein of unknown function (DUF454)
GEOBRER4_RS06990	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS07000	COG4251	negative regulation of phosphorylation
GEOBRER4_RS07005	COG0789	Transcriptional regulator
GEOBRER4_RS07020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GEOBRER4_RS07030	COG1703	isobutyryl-CoA mutase activity
GEOBRER4_RS07030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS07030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS07045	COG0183	Belongs to the thiolase family
GEOBRER4_RS07050	COG1250	3-hydroxyacyl-CoA dehydrogenase
GEOBRER4_RS07055	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS07060	COG1960	acyl-CoA dehydrogenase activity
GEOBRER4_RS07065	COG2181	nitrate reductase activity
GEOBRER4_RS07065	COG0247	lactate metabolic process
GEOBRER4_RS07075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GEOBRER4_RS07090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GEOBRER4_RS07095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GEOBRER4_RS07120	COG0430	RNA-3'-phosphate cyclase activity
GEOBRER4_RS07125	COG3290	protein histidine kinase activity
GEOBRER4_RS07125	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS07130	COG0494	nUDIX hydrolase
GEOBRER4_RS07135	COG2860	membrane
GEOBRER4_RS07145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GEOBRER4_RS07170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GEOBRER4_RS07175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GEOBRER4_RS07180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GEOBRER4_RS07185	COG3852	Histidine kinase
GEOBRER4_RS07195	COG1335	isochorismatase
GEOBRER4_RS07200	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS07210	COG0305	Participates in initiation and elongation during chromosome replication
GEOBRER4_RS07225	COG1193	negative regulation of DNA recombination
GEOBRER4_RS07230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GEOBRER4_RS07235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GEOBRER4_RS07240	COG1027	Aspartate ammonia-lyase
GEOBRER4_RS07270	COG3040	lipid binding
GEOBRER4_RS07290	COG0785	Cytochrome C biogenesis protein
GEOBRER4_RS07295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GEOBRER4_RS07305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GEOBRER4_RS07315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS07315	COG4191	Histidine kinase
GEOBRER4_RS07320	COG4565	transcriptional regulatory protein
GEOBRER4_RS07330	COG0513	Belongs to the DEAD box helicase family
GEOBRER4_RS07335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GEOBRER4_RS07355	COG0585	pseudouridine synthase activity
GEOBRER4_RS07360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GEOBRER4_RS07400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GEOBRER4_RS07405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GEOBRER4_RS07410	COG0193	aminoacyl-tRNA hydrolase activity
GEOBRER4_RS07415	COG0012	GTP binding
GEOBRER4_RS07420	COG0360	Binds together with S18 to 16S ribosomal RNA
GEOBRER4_RS07425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GEOBRER4_RS07435	COG0359	binds to the 23S rRNA
GEOBRER4_RS07455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GEOBRER4_RS07465	COG0052	Belongs to the universal ribosomal protein uS2 family
GEOBRER4_RS07470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GEOBRER4_RS07475	COG0528	UMP kinase activity
GEOBRER4_RS07480	COG0233	cytoplasmic translational termination
GEOBRER4_RS07485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GEOBRER4_RS07490	COG4589	Belongs to the CDS family
GEOBRER4_RS07495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GEOBRER4_RS07500	COG0750	zinc metalloprotease
GEOBRER4_RS07505	COG1214	PFAM Peptidase M22, glycoprotease
GEOBRER4_RS07510	COG0129	dihydroxy-acid dehydratase activity
GEOBRER4_RS07515	COG0028	Belongs to the TPP enzyme family
GEOBRER4_RS07520	COG0440	acetolactate synthase activity
GEOBRER4_RS07525	COG0688	phosphatidylethanolamine metabolic process
GEOBRER4_RS07530	COG1183	phosphatidylcholine synthase activity
GEOBRER4_RS07535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GEOBRER4_RS07550	COG1278	Cold shock
GEOBRER4_RS07555	COG1611	Belongs to the LOG family
GEOBRER4_RS07560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GEOBRER4_RS07575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GEOBRER4_RS07605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GEOBRER4_RS07620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GEOBRER4_RS07630	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GEOBRER4_RS07640	COG0312	modulator of DNA gyrase
GEOBRER4_RS07665	COG5002	protein histidine kinase activity
GEOBRER4_RS07675	COG0826	peptidase U32
GEOBRER4_RS07685	COG0758	DNA mediated transformation
GEOBRER4_RS07685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GEOBRER4_RS07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GEOBRER4_RS07695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GEOBRER4_RS07705	COG0424	maF-like protein
GEOBRER4_RS07710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GEOBRER4_RS07725	COG0488	(ABC) transporter
GEOBRER4_RS07735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GEOBRER4_RS07820	COG0537	adenosine 5'-monophosphoramidase activity
GEOBRER4_RS07825	COG1403	HNH endonuclease
GEOBRER4_RS07925	COG0582	viral genome integration into host DNA
GEOBRER4_RS07930	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GEOBRER4_RS07935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS07935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GEOBRER4_RS07940	COG1703	isobutyryl-CoA mutase activity
GEOBRER4_RS07965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GEOBRER4_RS07970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GEOBRER4_RS07980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GEOBRER4_RS08015	COG3646	Phage regulatory protein
GEOBRER4_RS08045	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GEOBRER4_RS08075	COG3973	AAA domain
GEOBRER4_RS08090	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS08100	COG3108	Peptidase M15
GEOBRER4_RS08105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GEOBRER4_RS08125	COG2204	response regulator
GEOBRER4_RS08130	COG3852	Histidine kinase
GEOBRER4_RS08140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GEOBRER4_RS08145	COG0537	adenosine 5'-monophosphoramidase activity
GEOBRER4_RS08155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GEOBRER4_RS08170	COG2208	phosphoserine phosphatase activity
GEOBRER4_RS08180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GEOBRER4_RS08195	COG0601	transmembrane transport
GEOBRER4_RS08200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GEOBRER4_RS08210	COG0037	tRNA processing
GEOBRER4_RS08215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GEOBRER4_RS08220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GEOBRER4_RS08225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GEOBRER4_RS08240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GEOBRER4_RS08245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GEOBRER4_RS08250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GEOBRER4_RS08260	COG2814	Major facilitator Superfamily
GEOBRER4_RS08265	COG1566	PFAM secretion protein HlyD family protein
GEOBRER4_RS08280	COG2414	aldehyde ferredoxin oxidoreductase
GEOBRER4_RS08295	COG2226	methyltransferase
GEOBRER4_RS08305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GEOBRER4_RS08320	COG4149	molybdate abc transporter
GEOBRER4_RS08325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GEOBRER4_RS08330	COG0443	Heat shock 70 kDa protein
GEOBRER4_RS08340	COG0741	lytic transglycosylase activity
GEOBRER4_RS08345	COG0557	exoribonuclease II activity
GEOBRER4_RS08350	COG0805	protein transport
GEOBRER4_RS08355	COG0196	riboflavin kinase activity
GEOBRER4_RS08370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GEOBRER4_RS08375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS08385	COG1459	type II secretion system
GEOBRER4_RS08390	COG5002	protein histidine kinase activity
GEOBRER4_RS08395	COG2204	response regulator
GEOBRER4_RS08400	COG4969	Belongs to the N-Me-Phe pilin family
GEOBRER4_RS08420	COG1131	(ABC) transporter
GEOBRER4_RS08440	COG1216	Glycosyl transferase, family 2
GEOBRER4_RS08465	COG2226	methyltransferase
GEOBRER4_RS08480	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS08505	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS08520	COG1968	undecaprenyl-diphosphatase activity
GEOBRER4_RS08535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GEOBRER4_RS08550	COG2204	response regulator
GEOBRER4_RS08555	COG0330	HflC and HflK could
GEOBRER4_RS08560	COG1528	Iron-storage protein
GEOBRER4_RS08570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GEOBRER4_RS08640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GEOBRER4_RS08645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GEOBRER4_RS08650	COG1077	Cell shape determining protein MreB Mrl
GEOBRER4_RS08660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GEOBRER4_RS08665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GEOBRER4_RS08675	COG0730	response to heat
GEOBRER4_RS08720	COG0784	Response regulator, receiver
GEOBRER4_RS08720	COG2198	Histidine kinase
GEOBRER4_RS08720	COG5002	protein histidine kinase activity
GEOBRER4_RS08770	COG0471	metal ion transport
GEOBRER4_RS08775	COG1959	2 iron, 2 sulfur cluster binding
GEOBRER4_RS08780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GEOBRER4_RS08810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GEOBRER4_RS08815	COG2226	methyltransferase
GEOBRER4_RS08835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GEOBRER4_RS08840	COG0390	transport system, permease component
GEOBRER4_RS08855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS08860	COG0765	amino acid transport
GEOBRER4_RS08885	COG0861	Integral membrane protein TerC family
GEOBRER4_RS08890	COG1615	UPF0182 protein
GEOBRER4_RS08950	COG0442	prolyl-tRNA aminoacylation
GEOBRER4_RS08955	COG0733	neurotransmitter:sodium symporter activity
GEOBRER4_RS08960	COG2962	Rard protein
GEOBRER4_RS08965	COG0784	Response regulator, receiver
GEOBRER4_RS08965	COG4191	Histidine kinase
GEOBRER4_RS08970	COG4251	negative regulation of phosphorylation
GEOBRER4_RS08975	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS08980	COG0512	Glutamine amidotransferase of anthranilate synthase
GEOBRER4_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GEOBRER4_RS08990	COG0134	indole-3-glycerol-phosphate synthase activity
GEOBRER4_RS08995	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GEOBRER4_RS09000	COG0135	phosphoribosylanthranilate isomerase activity
GEOBRER4_RS09005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GEOBRER4_RS09010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GEOBRER4_RS09015	COG1335	isochorismatase
GEOBRER4_RS09020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GEOBRER4_RS09045	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GEOBRER4_RS09060	COG4464	protein tyrosine phosphatase activity
GEOBRER4_RS09065	COG0482	sulfurtransferase activity
GEOBRER4_RS09085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GEOBRER4_RS09095	COG2873	o-acetylhomoserine
GEOBRER4_RS09100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GEOBRER4_RS09105	COG5557	Pfam Polysulphide reductase, NrfD
GEOBRER4_RS09110	COG1525	nuclease
GEOBRER4_RS09120	COG4191	Histidine kinase
GEOBRER4_RS09140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GEOBRER4_RS09145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GEOBRER4_RS09150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GEOBRER4_RS09155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GEOBRER4_RS09160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GEOBRER4_RS09165	COG0072	phenylalanine-tRNA ligase activity
GEOBRER4_RS09170	COG0776	regulation of translation
GEOBRER4_RS09190	COG2995	paraquat-inducible protein a
GEOBRER4_RS09195	COG3008	intermembrane lipid transfer
GEOBRER4_RS09195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GEOBRER4_RS09205	COG0837	glucose binding
GEOBRER4_RS09215	COG0545	Peptidyl-prolyl cis-trans isomerase
GEOBRER4_RS09235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GEOBRER4_RS09295	COG0789	Transcriptional regulator
GEOBRER4_RS09315	COG1271	oxidase subunit
GEOBRER4_RS09320	COG1294	oxidase, subunit
GEOBRER4_RS09335	COG0318	PFAM AMP-dependent synthetase and ligase
GEOBRER4_RS09345	COG0579	oxidoreductase
GEOBRER4_RS09355	COG4251	negative regulation of phosphorylation
GEOBRER4_RS09360	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS09365	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS09370	COG2198	Histidine kinase
GEOBRER4_RS09370	COG0784	Response regulator, receiver
GEOBRER4_RS09370	COG0643	Histidine kinase
GEOBRER4_RS09380	COG0835	chemotaxis
GEOBRER4_RS09390	COG0835	chemotaxis
GEOBRER4_RS09425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GEOBRER4_RS09440	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GEOBRER4_RS09445	COG1054	Belongs to the UPF0176 family
GEOBRER4_RS09450	COG1305	Transglutaminase-like
GEOBRER4_RS09485	COG3706	GGDEF domain
GEOBRER4_RS09490	COG4251	negative regulation of phosphorylation
GEOBRER4_RS09495	COG0084	hydrolase, TatD family'
GEOBRER4_RS09500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GEOBRER4_RS09510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GEOBRER4_RS09515	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GEOBRER4_RS09520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GEOBRER4_RS09535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GEOBRER4_RS09545	COG0776	regulation of translation
GEOBRER4_RS09555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GEOBRER4_RS09555	COG0248	Ppx GppA phosphatase
GEOBRER4_RS09570	COG0545	Peptidyl-prolyl cis-trans isomerase
GEOBRER4_RS09580	COG2132	Multicopper oxidase
GEOBRER4_RS09590	COG2199	diguanylate cyclase activity
GEOBRER4_RS09605	COG2198	Histidine kinase
GEOBRER4_RS09605	COG0784	Response regulator, receiver
GEOBRER4_RS09605	COG2205	protein histidine kinase activity
GEOBRER4_RS09610	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS09615	COG2204	response regulator
GEOBRER4_RS09665	COG0515	serine threonine protein kinase
GEOBRER4_RS09665	COG2815	serine threonine protein kinase
GEOBRER4_RS09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GEOBRER4_RS09765	COG0318	PFAM AMP-dependent synthetase and ligase
GEOBRER4_RS09770	COG0596	Alpha beta hydrolase
GEOBRER4_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GEOBRER4_RS09790	COG2070	2-Nitropropane dioxygenase
GEOBRER4_RS09790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GEOBRER4_RS09815	COG1773	rubredoxin
GEOBRER4_RS09855	COG3437	response regulator, receiver
GEOBRER4_RS09870	COG5001	Diguanylate cyclase
GEOBRER4_RS09870	COG3300	MHYT domain
GEOBRER4_RS09885	COG1022	Amp-dependent synthetase and ligase
GEOBRER4_RS09890	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS09890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GEOBRER4_RS09895	COG0183	Belongs to the thiolase family
GEOBRER4_RS09900	COG1960	acyl-CoA dehydrogenase activity
GEOBRER4_RS09915	COG4251	negative regulation of phosphorylation
GEOBRER4_RS09930	COG1902	pentaerythritol trinitrate reductase activity
GEOBRER4_RS09940	COG0670	Belongs to the BI1 family
GEOBRER4_RS09950	COG0784	Response regulator, receiver
GEOBRER4_RS09950	COG4191	Histidine kinase
GEOBRER4_RS09975	COG1979	alcohol dehydrogenase
GEOBRER4_RS09980	COG2207	Transcriptional regulator
GEOBRER4_RS09985	COG0667	Aldo Keto reductase
GEOBRER4_RS09990	COG0656	L-ascorbic acid biosynthetic process
GEOBRER4_RS09995	COG2814	Major facilitator Superfamily
GEOBRER4_RS10000	COG0655	NAD(P)H dehydrogenase (quinone) activity
GEOBRER4_RS10005	COG1979	alcohol dehydrogenase
GEOBRER4_RS10015	COG0667	Aldo Keto reductase
GEOBRER4_RS10025	COG2207	Transcriptional regulator
GEOBRER4_RS10035	COG1606	tRNA processing
GEOBRER4_RS10045	COG1691	(AIR) carboxylase
GEOBRER4_RS10175	COG0303	'Molybdopterin
GEOBRER4_RS10180	COG0730	response to heat
GEOBRER4_RS10200	COG0717	Belongs to the dCTP deaminase family
GEOBRER4_RS10220	COG2204	response regulator
GEOBRER4_RS10225	COG4191	Histidine kinase
GEOBRER4_RS10240	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GEOBRER4_RS10245	COG2217	Heavy metal translocating P-type atpase
GEOBRER4_RS10255	COG1136	(ABC) transporter
GEOBRER4_RS10255	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS10260	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS10260	COG1136	(ABC) transporter
GEOBRER4_RS10270	COG2217	Heavy metal translocating P-type atpase
GEOBRER4_RS10275	COG1937	Protein conserved in bacteria
GEOBRER4_RS10285	COG0446	pyridine nucleotide-disulphide oxidoreductase
GEOBRER4_RS10305	COG3576	pyridoxamine 5-phosphate
GEOBRER4_RS10315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GEOBRER4_RS10355	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GEOBRER4_RS10370	COG1950	PFAM Membrane protein of
GEOBRER4_RS10385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GEOBRER4_RS10400	COG1136	(ABC) transporter
GEOBRER4_RS10400	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS10405	COG1136	(ABC) transporter
GEOBRER4_RS10410	COG1566	PFAM secretion protein HlyD family protein
GEOBRER4_RS10460	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS10490	COG2814	Major facilitator Superfamily
GEOBRER4_RS10495	COG1022	Amp-dependent synthetase and ligase
GEOBRER4_RS10505	COG0626	cystathionine gamma-synthase activity
GEOBRER4_RS10510	COG0626	cystathionine gamma-synthase activity
GEOBRER4_RS10525	COG1671	Belongs to the UPF0178 family
GEOBRER4_RS10530	COG1278	Cold shock
GEOBRER4_RS10535	COG1122	ATPase activity
GEOBRER4_RS10540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GEOBRER4_RS10545	COG0310	cobalt ion transport
GEOBRER4_RS10555	COG3064	Membrane
GEOBRER4_RS10565	COG2062	phosphohistidine phosphatase, SixA
GEOBRER4_RS10580	COG0835	chemotaxis
GEOBRER4_RS10585	COG0058	SHG alpha-glucan phosphorylase activity
GEOBRER4_RS10590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GEOBRER4_RS10590	COG4651	solute:proton antiporter activity
GEOBRER4_RS10595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GEOBRER4_RS10605	COG4651	solute:proton antiporter activity
GEOBRER4_RS10605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GEOBRER4_RS10610	COG2204	response regulator
GEOBRER4_RS10615	COG4191	Histidine kinase
GEOBRER4_RS10630	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS10660	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS10670	COG0508	dehydrogenase complex catalyzes the overall conversion of
GEOBRER4_RS10675	COG0022	dehydrogenase e1 component
GEOBRER4_RS10675	COG0508	dehydrogenase complex catalyzes the overall conversion of
GEOBRER4_RS10680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GEOBRER4_RS10685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GEOBRER4_RS10700	COG4221	oxidoreductase activity
GEOBRER4_RS10710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS10715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GEOBRER4_RS10720	COG5557	Pfam Polysulphide reductase, NrfD
GEOBRER4_RS10725	COG3064	Membrane
GEOBRER4_RS10725	COG0437	4 iron, 4 sulfur cluster binding
GEOBRER4_RS10735	COG2204	response regulator
GEOBRER4_RS10740	COG4191	Histidine kinase
GEOBRER4_RS10750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GEOBRER4_RS10755	COG0303	'Molybdopterin
GEOBRER4_RS10765	COG0521	Mo-molybdopterin cofactor biosynthetic process
GEOBRER4_RS10770	COG0280	phosphate acetyltransferase
GEOBRER4_RS10775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GEOBRER4_RS10785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GEOBRER4_RS10790	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GEOBRER4_RS10795	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS10805	COG0018	arginyl-trna synthetase
GEOBRER4_RS10820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GEOBRER4_RS10830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GEOBRER4_RS10835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GEOBRER4_RS10840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GEOBRER4_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GEOBRER4_RS10860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GEOBRER4_RS10860	COG3620	sequence-specific DNA binding
GEOBRER4_RS10860	COG0617	tRNA 3'-terminal CCA addition
GEOBRER4_RS10865	COG1355	regulation of microtubule-based process
GEOBRER4_RS10870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GEOBRER4_RS10880	COG0180	Tryptophanyl-tRNA synthetase
GEOBRER4_RS10885	COG1994	Peptidase M50
GEOBRER4_RS10895	COG0419	ATPase involved in DNA repair
GEOBRER4_RS10920	COG4807	Protein conserved in bacteria
GEOBRER4_RS10925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GEOBRER4_RS10935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GEOBRER4_RS10945	COG0613	PHP domain protein
GEOBRER4_RS10955	COG1592	Rubrerythrin
GEOBRER4_RS10960	COG1285	pathogenesis
GEOBRER4_RS10965	COG1100	Small GTP-binding protein
GEOBRER4_RS10985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GEOBRER4_RS10990	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GEOBRER4_RS10990	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GEOBRER4_RS10995	COG0157	Belongs to the NadC ModD family
GEOBRER4_RS11035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GEOBRER4_RS11040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GEOBRER4_RS11045	COG0047	phosphoribosylformylglycinamidine synthase activity
GEOBRER4_RS11055	COG0668	transmembrane transport
GEOBRER4_RS11060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GEOBRER4_RS11065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GEOBRER4_RS11070	COG2205	protein histidine kinase activity
GEOBRER4_RS11080	COG0126	phosphoglycerate kinase activity
GEOBRER4_RS11085	COG0149	triose-phosphate isomerase activity
GEOBRER4_RS11140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GEOBRER4_RS11145	COG0798	PFAM Bile acid sodium symporter
GEOBRER4_RS11150	COG0640	Transcriptional regulator
GEOBRER4_RS11160	COG2895	sulfate adenylyltransferase (ATP) activity
GEOBRER4_RS11165	COG0175	sulfate reduction
GEOBRER4_RS11170	COG0175	sulfate reduction
GEOBRER4_RS11175	COG0534	Mate efflux family protein
GEOBRER4_RS11200	COG4221	oxidoreductase activity
GEOBRER4_RS11210	COG2853	Lipoprotein
GEOBRER4_RS11220	COG2358	TRAP transporter, solute receptor (TAXI family
GEOBRER4_RS11230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GEOBRER4_RS11235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GEOBRER4_RS11240	COG1309	transcriptional regulator
GEOBRER4_RS11265	COG0739	heme binding
GEOBRER4_RS11295	COG2198	Histidine kinase
GEOBRER4_RS11295	COG0784	Response regulator, receiver
GEOBRER4_RS11295	COG0643	Histidine kinase
GEOBRER4_RS11300	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS11315	COG4191	Histidine kinase
GEOBRER4_RS11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS11325	COG4206	TonB-dependent receptor
GEOBRER4_RS11345	COG2208	phosphoserine phosphatase activity
GEOBRER4_RS11350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GEOBRER4_RS11355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GEOBRER4_RS11365	COG1509	lysine 2,3-aminomutase activity
GEOBRER4_RS11370	COG0167	dihydroorotate dehydrogenase activity
GEOBRER4_RS11375	COG0543	2 iron, 2 sulfur cluster binding
GEOBRER4_RS11380	COG0456	acetyltransferase
GEOBRER4_RS11385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GEOBRER4_RS11390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GEOBRER4_RS11400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GEOBRER4_RS11410	COG0784	Response regulator, receiver
GEOBRER4_RS11410	COG4191	Histidine kinase
GEOBRER4_RS11420	COG2204	response regulator
GEOBRER4_RS11430	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GEOBRER4_RS11435	COG1012	belongs to the aldehyde dehydrogenase family
GEOBRER4_RS11440	COG2204	response regulator
GEOBRER4_RS11445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GEOBRER4_RS11465	COG4948	Mandelate Racemase Muconate Lactonizing
GEOBRER4_RS11475	COG3852	Histidine kinase
GEOBRER4_RS11495	COG1704	LemA family
GEOBRER4_RS11510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GEOBRER4_RS11520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GEOBRER4_RS11525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GEOBRER4_RS11525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GEOBRER4_RS11535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GEOBRER4_RS11540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GEOBRER4_RS11545	COG1862	Preprotein translocase
GEOBRER4_RS11550	COG0343	queuine tRNA-ribosyltransferase activity
GEOBRER4_RS11555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GEOBRER4_RS11560	COG2385	sporulation resulting in formation of a cellular spore
GEOBRER4_RS11570	COG0444	Belongs to the ABC transporter superfamily
GEOBRER4_RS11575	COG4608	Belongs to the ABC transporter superfamily
GEOBRER4_RS11585	COG0312	modulator of DNA gyrase
GEOBRER4_RS11590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GEOBRER4_RS11595	COG0497	DNA recombination
GEOBRER4_RS11600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GEOBRER4_RS11605	COG0058	SHG alpha-glucan phosphorylase activity
GEOBRER4_RS11610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GEOBRER4_RS11615	COG0205	6-phosphofructokinase activity
GEOBRER4_RS11655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GEOBRER4_RS11670	COG0772	Belongs to the SEDS family
GEOBRER4_RS11675	COG0768	penicillin binding
GEOBRER4_RS11695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GEOBRER4_RS11705	COG1489	DNA binding
GEOBRER4_RS11720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GEOBRER4_RS11735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GEOBRER4_RS11740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GEOBRER4_RS11750	COG0655	NAD(P)H dehydrogenase (quinone) activity
GEOBRER4_RS11755	COG1335	isochorismatase
GEOBRER4_RS11760	COG2814	Major facilitator Superfamily
GEOBRER4_RS11770	COG0477	Major facilitator Superfamily
GEOBRER4_RS11775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GEOBRER4_RS11785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GEOBRER4_RS11800	COG0505	Belongs to the CarA family
GEOBRER4_RS11805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GEOBRER4_RS11810	COG0540	Belongs to the ATCase OTCase family
GEOBRER4_RS11815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GEOBRER4_RS11820	COG1534	Rna-binding protein
GEOBRER4_RS11825	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GEOBRER4_RS11830	COG0742	ribosomal rna small subunit methyltransferase
GEOBRER4_RS11835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GEOBRER4_RS11855	COG0288	reversible hydration of carbon dioxide
GEOBRER4_RS11875	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS11880	COG0481	GTPase activity
GEOBRER4_RS11900	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GEOBRER4_RS11905	COG4974	Belongs to the 'phage' integrase family
GEOBRER4_RS11920	COG0077	Prephenate dehydratase
GEOBRER4_RS11920	COG1605	Chorismate mutase
GEOBRER4_RS11925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GEOBRER4_RS11930	COG0741	lytic transglycosylase activity
GEOBRER4_RS11935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GEOBRER4_RS11950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GEOBRER4_RS11955	COG0110	maltose O-acetyltransferase activity
GEOBRER4_RS11960	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS11960	COG3290	protein histidine kinase activity
GEOBRER4_RS11970	COG0730	response to heat
GEOBRER4_RS11995	COG2204	response regulator
GEOBRER4_RS12000	COG4191	Histidine kinase
GEOBRER4_RS12030	COG1696	Membrane protein involved in D-alanine export
GEOBRER4_RS12045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GEOBRER4_RS12080	COG1216	Glycosyl transferase, family 2
GEOBRER4_RS12110	COG0297	glycogen (starch) synthase activity
GEOBRER4_RS12125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GEOBRER4_RS12155	COG0367	asparagine synthase
GEOBRER4_RS12185	COG3267	Type II secretory pathway component ExeA
GEOBRER4_RS12185	COG3409	Peptidoglycan-binding domain 1 protein
GEOBRER4_RS12190	COG0489	protein tyrosine kinase activity
GEOBRER4_RS12195	COG3944	biosynthesis protein
GEOBRER4_RS12205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GEOBRER4_RS12245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GEOBRER4_RS12255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GEOBRER4_RS12270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GEOBRER4_RS12275	COG0860	N-Acetylmuramoyl-L-alanine amidase
GEOBRER4_RS12305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GEOBRER4_RS12310	COG5012	cobalamin binding
GEOBRER4_RS12320	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GEOBRER4_RS12330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GEOBRER4_RS12360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GEOBRER4_RS12365	COG4208	sulfate ABC transporter
GEOBRER4_RS12370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GEOBRER4_RS12375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GEOBRER4_RS12385	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GEOBRER4_RS12400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GEOBRER4_RS12405	COG0573	inorganic phosphate transmembrane transporter activity
GEOBRER4_RS12410	COG0581	inorganic phosphate transmembrane transporter activity
GEOBRER4_RS12415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GEOBRER4_RS12420	COG0704	Plays a role in the regulation of phosphate uptake
GEOBRER4_RS12425	COG1872	DUF167
GEOBRER4_RS12430	COG0251	oxidation-reduction process
GEOBRER4_RS12440	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS12475	COG1971	Probably functions as a manganese efflux pump
GEOBRER4_RS12480	COG1032	radical SAM domain protein
GEOBRER4_RS12485	COG2824	Alkylphosphonate utilization operon protein PhnA
GEOBRER4_RS12510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GEOBRER4_RS12530	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS12540	COG1063	alcohol dehydrogenase
GEOBRER4_RS12545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GEOBRER4_RS12550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GEOBRER4_RS12555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GEOBRER4_RS12565	COG2823	Periplasmic or secreted lipoprotein
GEOBRER4_RS12585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GEOBRER4_RS12590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GEOBRER4_RS12595	COG3481	metal-dependent phosphohydrolase, HD sub domain
GEOBRER4_RS12600	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GEOBRER4_RS12610	COG4191	Histidine kinase
GEOBRER4_RS12620	COG2204	response regulator
GEOBRER4_RS12640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GEOBRER4_RS12650	COG0105	UTP biosynthetic process
GEOBRER4_RS12660	COG3885	ferrous iron binding
GEOBRER4_RS12660	COG2078	PFAM AMMECR1 domain protein
GEOBRER4_RS12675	COG0318	PFAM AMP-dependent synthetase and ligase
GEOBRER4_RS12680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GEOBRER4_RS12690	COG0793	Belongs to the peptidase S41A family
GEOBRER4_RS12695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GEOBRER4_RS12700	COG1045	serine acetyltransferase
GEOBRER4_RS12705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GEOBRER4_RS12710	COG4251	negative regulation of phosphorylation
GEOBRER4_RS12720	COG2983	Belongs to the UPF0260 family
GEOBRER4_RS12730	COG3409	Peptidoglycan-binding domain 1 protein
GEOBRER4_RS12730	COG3267	Type II secretory pathway component ExeA
GEOBRER4_RS12765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GEOBRER4_RS12770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GEOBRER4_RS12775	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS12780	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS12825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GEOBRER4_RS12835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GEOBRER4_RS12840	COG0504	CTP synthase activity
GEOBRER4_RS12845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GEOBRER4_RS12850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GEOBRER4_RS12855	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS12860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GEOBRER4_RS12870	COG0643	Histidine kinase
GEOBRER4_RS12870	COG2198	Histidine kinase
GEOBRER4_RS12875	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS12895	COG1918	ferrous iron import across plasma membrane
GEOBRER4_RS12895	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GEOBRER4_RS12925	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GEOBRER4_RS12950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GEOBRER4_RS13020	COG1201	RNA secondary structure unwinding
GEOBRER4_RS13025	COG1119	ATPase activity
GEOBRER4_RS13050	COG0033	Phosphoglucomutase
GEOBRER4_RS13060	COG2816	NAD+ diphosphatase activity
GEOBRER4_RS13065	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GEOBRER4_RS13070	COG0509	glycine decarboxylation via glycine cleavage system
GEOBRER4_RS13075	COG0439	Biotin carboxylase
GEOBRER4_RS13080	COG0511	ligase activity, forming carbon-carbon bonds
GEOBRER4_RS13085	COG0006	proline dipeptidase activity
GEOBRER4_RS13090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GEOBRER4_RS13105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GEOBRER4_RS13110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GEOBRER4_RS13115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GEOBRER4_RS13210	COG2204	response regulator
GEOBRER4_RS13215	COG3850	Histidine kinase
GEOBRER4_RS13215	COG5002	protein histidine kinase activity
GEOBRER4_RS13225	COG0525	valine-tRNA ligase activity
GEOBRER4_RS13235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GEOBRER4_RS13245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GEOBRER4_RS13250	COG0653	protein targeting
GEOBRER4_RS13255	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GEOBRER4_RS13265	COG4191	Histidine kinase
GEOBRER4_RS13270	COG2204	response regulator
GEOBRER4_RS13295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GEOBRER4_RS13310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GEOBRER4_RS13330	COG0483	inositol monophosphate 1-phosphatase activity
GEOBRER4_RS13340	COG0004	ammonium transporteR
GEOBRER4_RS13360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GEOBRER4_RS13370	COG0247	lactate metabolic process
GEOBRER4_RS13370	COG2181	nitrate reductase activity
GEOBRER4_RS13375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GEOBRER4_RS13390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GEOBRER4_RS13410	COG1872	DUF167
GEOBRER4_RS13430	COG0582	viral genome integration into host DNA
GEOBRER4_RS13450	COG1111	helicase
GEOBRER4_RS13450	COG1205	dead DEAH box helicase
GEOBRER4_RS13460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GEOBRER4_RS13465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GEOBRER4_RS13480	COG1201	RNA secondary structure unwinding
GEOBRER4_RS13515	COG0210	DNA helicase
GEOBRER4_RS13555	COG1397	ADP-ribosylglycohydrolase
GEOBRER4_RS13580	COG1487	ribonuclease activity
GEOBRER4_RS13585	COG1074	ATP-dependent DNA helicase activity
GEOBRER4_RS13660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GEOBRER4_RS13670	COG2801	Transposase and inactivated derivatives
GEOBRER4_RS13715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GEOBRER4_RS13765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GEOBRER4_RS13815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GEOBRER4_RS13820	COG2207	Transcriptional regulator
GEOBRER4_RS13820	COG1917	Cupin 2, conserved barrel domain protein
GEOBRER4_RS13835	COG4106	trans-aconitate 2-methyltransferase activity
GEOBRER4_RS13840	COG0500	methyltransferase
GEOBRER4_RS13895	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GEOBRER4_RS13910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GEOBRER4_RS13920	COG0667	Aldo Keto reductase
GEOBRER4_RS13940	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS13945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GEOBRER4_RS13970	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GEOBRER4_RS13975	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GEOBRER4_RS14010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GEOBRER4_RS14015	COG2181	nitrate reductase activity
GEOBRER4_RS14015	COG0247	lactate metabolic process
GEOBRER4_RS14020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GEOBRER4_RS14040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GEOBRER4_RS14045	COG1454	alcohol dehydrogenase
GEOBRER4_RS14050	COG2414	aldehyde ferredoxin oxidoreductase
GEOBRER4_RS14060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GEOBRER4_RS14075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GEOBRER4_RS14080	COG2226	methyltransferase
GEOBRER4_RS14085	COG2070	2-Nitropropane dioxygenase
GEOBRER4_RS14090	COG5002	protein histidine kinase activity
GEOBRER4_RS14095	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS14100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GEOBRER4_RS14115	COG0450	alkyl hydroperoxide reductase
GEOBRER4_RS14125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GEOBRER4_RS14170	COG0789	Transcriptional regulator
GEOBRER4_RS14175	COG1379	DNA repair
GEOBRER4_RS14195	COG0280	phosphate acetyltransferase
GEOBRER4_RS14195	COG0281	malic enzyme
GEOBRER4_RS14220	COG0714	Associated with various cellular activities
GEOBRER4_RS14225	COG0602	queuosine metabolic process
GEOBRER4_RS14230	COG0720	synthase
GEOBRER4_RS14240	COG0009	L-threonylcarbamoyladenylate synthase
GEOBRER4_RS14245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GEOBRER4_RS14260	COG0756	dUTP diphosphatase activity
GEOBRER4_RS14265	COG0612	Peptidase, M16
GEOBRER4_RS14270	COG1185	polyribonucleotide nucleotidyltransferase activity
GEOBRER4_RS14275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GEOBRER4_RS14290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GEOBRER4_RS14295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GEOBRER4_RS14305	COG0195	Participates in both transcription termination and antitermination
GEOBRER4_RS14310	COG0779	Required for maturation of 30S ribosomal subunits
GEOBRER4_RS14320	COG1011	Hydrolase
GEOBRER4_RS14340	COG1049	propionate catabolic process, 2-methylcitrate cycle
GEOBRER4_RS14345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GEOBRER4_RS14360	COG0793	Belongs to the peptidase S41A family
GEOBRER4_RS14370	COG2177	Part of the ABC transporter FtsEX involved in
GEOBRER4_RS14375	COG2884	Cell division ATP-binding protein ftsE
GEOBRER4_RS14380	COG2165	general secretion pathway protein
GEOBRER4_RS14415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS14430	COG1216	Glycosyl transferase, family 2
GEOBRER4_RS14460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GEOBRER4_RS14465	COG0740	serine-type endopeptidase activity
GEOBRER4_RS14470	COG0544	peptidyl-prolyl cis-trans isomerase activity
GEOBRER4_RS14475	COG1294	oxidase, subunit
GEOBRER4_RS14480	COG1271	oxidase subunit
GEOBRER4_RS14495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GEOBRER4_RS14500	COG0527	aspartate kinase activity
GEOBRER4_RS14505	COG0802	atpase or kinase
GEOBRER4_RS14515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GEOBRER4_RS14515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GEOBRER4_RS14520	COG0736	holo-[acyl-carrier-protein] synthase activity
GEOBRER4_RS14530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GEOBRER4_RS14540	COG1722	exodeoxyribonuclease VII activity
GEOBRER4_RS14545	COG1570	exodeoxyribonuclease VII activity
GEOBRER4_RS14550	COG1192	Involved in chromosome partitioning
GEOBRER4_RS14565	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GEOBRER4_RS14570	COG2010	Cytochrome c
GEOBRER4_RS14580	COG1151	hydroxylamine reductase activity
GEOBRER4_RS14590	COG3278	Belongs to the heme-copper respiratory oxidase family
GEOBRER4_RS14620	COG2217	Heavy metal translocating P-type atpase
GEOBRER4_RS14655	COG2814	Major facilitator Superfamily
GEOBRER4_RS14665	COG1794	racemase activity, acting on amino acids and derivatives
GEOBRER4_RS14670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GEOBRER4_RS14680	COG3267	Type II secretory pathway component ExeA
GEOBRER4_RS14680	COG3409	Peptidoglycan-binding domain 1 protein
GEOBRER4_RS14710	COG3437	response regulator, receiver
GEOBRER4_RS14710	COG0784	Response regulator, receiver
GEOBRER4_RS14730	COG1846	Transcriptional regulator
GEOBRER4_RS14735	COG2353	YceI-like domain
GEOBRER4_RS14765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GEOBRER4_RS14780	COG3706	GGDEF domain
GEOBRER4_RS14785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GEOBRER4_RS14790	COG3384	dioxygenase
GEOBRER4_RS14815	COG0667	Aldo Keto reductase
GEOBRER4_RS14860	COG0519	Catalyzes the synthesis of GMP from XMP
GEOBRER4_RS14890	COG4771	TonB-dependent receptor
GEOBRER4_RS14900	COG0686	Belongs to the AlaDH PNT family
GEOBRER4_RS14905	COG3158	transport of potassium into the cell
GEOBRER4_RS14910	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS14915	COG2205	protein histidine kinase activity
GEOBRER4_RS14925	COG1151	hydroxylamine reductase activity
GEOBRER4_RS14930	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS14960	COG2261	transglycosylase associated protein
GEOBRER4_RS14965	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GEOBRER4_RS14980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GEOBRER4_RS14980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GEOBRER4_RS14995	COG2181	nitrate reductase activity
GEOBRER4_RS14995	COG0247	lactate metabolic process
GEOBRER4_RS15000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GEOBRER4_RS15010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GEOBRER4_RS15015	COG0045	succinate-CoA ligase (ADP-forming) activity
GEOBRER4_RS15020	COG2181	nitrate reductase activity
GEOBRER4_RS15020	COG0247	lactate metabolic process
GEOBRER4_RS15025	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS15030	COG1250	3-hydroxyacyl-CoA dehydrogenase
GEOBRER4_RS15035	COG0183	Belongs to the thiolase family
GEOBRER4_RS15045	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS15050	COG2226	methyltransferase
GEOBRER4_RS15055	COG0281	malic enzyme
GEOBRER4_RS15055	COG0280	phosphate acetyltransferase
GEOBRER4_RS15065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GEOBRER4_RS15095	COG1233	COG1233 Phytoene dehydrogenase and related
GEOBRER4_RS15100	COG0247	lactate metabolic process
GEOBRER4_RS15100	COG2181	nitrate reductase activity
GEOBRER4_RS15110	COG2414	aldehyde ferredoxin oxidoreductase
GEOBRER4_RS15115	COG1024	Enoyl-CoA hydratase
GEOBRER4_RS15130	COG1959	2 iron, 2 sulfur cluster binding
GEOBRER4_RS15135	COG0427	acetyl-CoA hydrolase
GEOBRER4_RS15140	COG3290	protein histidine kinase activity
GEOBRER4_RS15140	COG3829	transcription factor binding
GEOBRER4_RS15145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GEOBRER4_RS15150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GEOBRER4_RS15160	COG0183	Belongs to the thiolase family
GEOBRER4_RS15165	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS15180	COG0730	response to heat
GEOBRER4_RS15190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GEOBRER4_RS15195	COG3608	succinylglutamate desuccinylase aspartoacylase
GEOBRER4_RS15195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GEOBRER4_RS15225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS15230	COG0280	phosphate acetyltransferase
GEOBRER4_RS15240	COG2414	aldehyde ferredoxin oxidoreductase
GEOBRER4_RS15245	COG1028	Short-chain dehydrogenase reductase Sdr
GEOBRER4_RS15250	COG3426	butyrate kinase activity
GEOBRER4_RS15280	COG2010	Cytochrome c
GEOBRER4_RS15280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GEOBRER4_RS15365	COG2223	nitrite transmembrane transporter activity
GEOBRER4_RS15385	COG4251	negative regulation of phosphorylation
GEOBRER4_RS15410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GEOBRER4_RS15415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GEOBRER4_RS15435	COG2885	chlorophyll binding
GEOBRER4_RS15435	COG3047	cAMP biosynthetic process
GEOBRER4_RS15525	COG5640	endopeptidase activity
GEOBRER4_RS15535	COG2226	methyltransferase
GEOBRER4_RS15540	COG1215	transferase activity, transferring glycosyl groups
GEOBRER4_RS15570	COG0463	Glycosyl transferase, family 2
GEOBRER4_RS15625	COG3852	Histidine kinase
GEOBRER4_RS15655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GEOBRER4_RS15675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GEOBRER4_RS15680	COG0318	PFAM AMP-dependent synthetase and ligase
GEOBRER4_RS15700	COG2198	Histidine kinase
GEOBRER4_RS15700	COG0643	Histidine kinase
GEOBRER4_RS15705	COG0835	chemotaxis
GEOBRER4_RS15710	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS15720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GEOBRER4_RS15725	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS15730	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS15730	COG3290	protein histidine kinase activity
GEOBRER4_RS15740	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS15745	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS15750	COG0583	DNA-binding transcription factor activity
GEOBRER4_RS15755	COG2814	Major facilitator Superfamily
GEOBRER4_RS15765	COG1151	hydroxylamine reductase activity
GEOBRER4_RS15780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GEOBRER4_RS15825	COG3047	cAMP biosynthetic process
GEOBRER4_RS15825	COG2885	chlorophyll binding
GEOBRER4_RS15830	COG1741	Belongs to the pirin family
GEOBRER4_RS15840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GEOBRER4_RS15875	COG1640	4-alpha-glucanotransferase
GEOBRER4_RS15885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GEOBRER4_RS15925	COG0791	NLP P60 protein
GEOBRER4_RS15935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GEOBRER4_RS15940	COG4535	Mg2 and Co2 transporter CorC
GEOBRER4_RS15945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GEOBRER4_RS15950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GEOBRER4_RS15960	COG0148	phosphopyruvate hydratase activity
GEOBRER4_RS15965	COG0564	pseudouridine synthase activity
GEOBRER4_RS15970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GEOBRER4_RS15980	COG3530	Putative quorum-sensing-regulated virulence factor
GEOBRER4_RS16015	COG1126	abc transporter atp-binding protein
GEOBRER4_RS16020	COG0765	amino acid transport
GEOBRER4_RS16040	COG1923	regulation of RNA biosynthetic process
GEOBRER4_RS16045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GEOBRER4_RS16050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GEOBRER4_RS16055	COG1686	Belongs to the peptidase S11 family
GEOBRER4_RS16065	COG2204	response regulator
GEOBRER4_RS16070	COG0784	Response regulator, receiver
GEOBRER4_RS16085	COG1388	LysM domain
GEOBRER4_RS16085	COG1376	ErfK ybiS ycfS ynhG family protein
GEOBRER4_RS16120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GEOBRER4_RS16125	COG1692	metallophosphoesterase
GEOBRER4_RS16135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GEOBRER4_RS16150	COG0552	protein localization to endoplasmic reticulum
GEOBRER4_RS16160	COG1196	nuclear chromosome segregation
GEOBRER4_RS16165	COG0203	ribosomal protein L17
GEOBRER4_RS16170	COG0202	RNA polymerase activity
GEOBRER4_RS16175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GEOBRER4_RS16180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GEOBRER4_RS16185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GEOBRER4_RS16190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GEOBRER4_RS16200	COG0563	adenylate kinase activity
GEOBRER4_RS16210	COG0200	Binds to the 23S rRNA
GEOBRER4_RS16215	COG1841	ribosomal large subunit assembly
GEOBRER4_RS16220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GEOBRER4_RS16225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GEOBRER4_RS16230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GEOBRER4_RS16235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GEOBRER4_RS16240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GEOBRER4_RS16245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GEOBRER4_RS16250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GEOBRER4_RS16255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GEOBRER4_RS16260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GEOBRER4_RS16265	COG0255	Belongs to the universal ribosomal protein uL29 family
GEOBRER4_RS16270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GEOBRER4_RS16275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GEOBRER4_RS16280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GEOBRER4_RS16285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GEOBRER4_RS16290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GEOBRER4_RS16295	COG0089	rRNA binding
GEOBRER4_RS16300	COG0088	Forms part of the polypeptide exit tunnel
GEOBRER4_RS16305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GEOBRER4_RS16310	COG0051	transcription antitermination factor activity, RNA binding
GEOBRER4_RS16320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GEOBRER4_RS16325	COG0049	tRNA binding
GEOBRER4_RS16330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GEOBRER4_RS16335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GEOBRER4_RS16340	COG0085	RNA polymerase activity
GEOBRER4_RS16345	COG0222	ribosome binding
GEOBRER4_RS16350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GEOBRER4_RS16360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GEOBRER4_RS16370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GEOBRER4_RS16380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GEOBRER4_RS16420	COG1032	radical SAM domain protein
GEOBRER4_RS16425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GEOBRER4_RS16435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GEOBRER4_RS16440	COG0101	tRNA pseudouridine synthase activity
GEOBRER4_RS16445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GEOBRER4_RS16455	COG0473	3-isopropylmalate dehydrogenase activity
GEOBRER4_RS16460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GEOBRER4_RS16465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GEOBRER4_RS16470	COG3852	Histidine kinase
GEOBRER4_RS16475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS16490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GEOBRER4_RS16495	COG5000	phosphorelay sensor kinase activity
GEOBRER4_RS16510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GEOBRER4_RS16515	COG1388	LysM domain
GEOBRER4_RS16515	COG0791	NLP P60 protein
GEOBRER4_RS16525	COG2226	methyltransferase
GEOBRER4_RS16530	COG2226	methyltransferase
GEOBRER4_RS16540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GEOBRER4_RS16540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GEOBRER4_RS16565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GEOBRER4_RS16585	COG3394	polysaccharide catabolic process
GEOBRER4_RS16600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GEOBRER4_RS16605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GEOBRER4_RS16615	COG1660	Displays ATPase and GTPase activities
GEOBRER4_RS16620	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GEOBRER4_RS16625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GEOBRER4_RS16630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GEOBRER4_RS16635	COG1137	ATPase activity
GEOBRER4_RS16650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GEOBRER4_RS16650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GEOBRER4_RS16665	COG0859	PFAM glycosyl transferase family 9
GEOBRER4_RS16675	COG0859	PFAM glycosyl transferase family 9
GEOBRER4_RS16685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GEOBRER4_RS16700	COG1216	Glycosyl transferase, family 2
GEOBRER4_RS16715	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS16720	COG0859	PFAM glycosyl transferase family 9
GEOBRER4_RS16725	COG1663	tetraacyldisaccharide 4'-kinase activity
GEOBRER4_RS16730	COG1519	Transferase
GEOBRER4_RS16740	COG1132	(ABC) transporter
GEOBRER4_RS16745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GEOBRER4_RS16760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GEOBRER4_RS16770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GEOBRER4_RS16775	COG1136	(ABC) transporter
GEOBRER4_RS16785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GEOBRER4_RS16795	COG0488	(ABC) transporter
GEOBRER4_RS16800	COG2226	methyltransferase
GEOBRER4_RS16810	COG0156	8-amino-7-oxononanoate synthase activity
GEOBRER4_RS16815	COG1451	nucleotide metabolic process
GEOBRER4_RS16845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GEOBRER4_RS16855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GEOBRER4_RS16875	COG1640	4-alpha-glucanotransferase
GEOBRER4_RS16885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GEOBRER4_RS16915	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS16915	COG3290	protein histidine kinase activity
GEOBRER4_RS16920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GEOBRER4_RS16960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GEOBRER4_RS16970	COG0564	pseudouridine synthase activity
GEOBRER4_RS17000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GEOBRER4_RS17020	COG0795	lipopolysaccharide-transporting ATPase activity
GEOBRER4_RS17040	COG0785	Cytochrome C biogenesis protein
GEOBRER4_RS17045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GEOBRER4_RS17050	COG2204	response regulator
GEOBRER4_RS17060	COG0142	geranyltranstransferase activity
GEOBRER4_RS17070	COG0166	Belongs to the GPI family
GEOBRER4_RS17075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GEOBRER4_RS17080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GEOBRER4_RS17085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GEOBRER4_RS17095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GEOBRER4_RS17095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GEOBRER4_RS17105	COG0792	nuclease activity
GEOBRER4_RS17110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GEOBRER4_RS17115	COG0335	large ribosomal subunit rRNA binding
GEOBRER4_RS17120	COG4752	Belongs to the RNA methyltransferase TrmD family
GEOBRER4_RS17125	COG0336	Belongs to the RNA methyltransferase TrmD family
GEOBRER4_RS17140	COG0228	four-way junction DNA binding
GEOBRER4_RS17145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GEOBRER4_RS17150	COG0425	Belongs to the sulfur carrier protein TusA family
GEOBRER4_RS17175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GEOBRER4_RS17185	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS17195	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS17200	COG0438	transferase activity, transferring glycosyl groups
GEOBRER4_RS17210	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GEOBRER4_RS17240	COG0463	Glycosyl transferase, family 2
GEOBRER4_RS17255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GEOBRER4_RS17260	COG1333	cytochrome c biogenesis protein
GEOBRER4_RS17270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GEOBRER4_RS17275	COG0151	Belongs to the GarS family
GEOBRER4_RS17280	COG0138	bifunctional purine biosynthesis protein purh
GEOBRER4_RS17295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GEOBRER4_RS17300	COG0351	phosphomethylpyrimidine kinase
GEOBRER4_RS17300	COG0352	thiamine-phosphate diphosphorylase activity
GEOBRER4_RS17305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GEOBRER4_RS17310	COG5002	protein histidine kinase activity
GEOBRER4_RS17325	COG1032	radical SAM domain protein
GEOBRER4_RS17335	COG1032	radical SAM domain protein
GEOBRER4_RS17430	COG0588	phosphoglycerate mutase activity
GEOBRER4_RS17435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GEOBRER4_RS17445	COG0484	heat shock protein binding
GEOBRER4_RS17450	COG0443	Heat shock 70 kDa protein
GEOBRER4_RS17455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GEOBRER4_RS17460	COG1420	regulation of RNA biosynthetic process
GEOBRER4_RS17465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GEOBRER4_RS17470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GEOBRER4_RS17490	COG0823	Involved in the tonB-independent uptake of proteins
GEOBRER4_RS17495	COG2885	chlorophyll binding
GEOBRER4_RS17515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GEOBRER4_RS17520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GEOBRER4_RS17525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GEOBRER4_RS17555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GEOBRER4_RS17560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GEOBRER4_RS17560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GEOBRER4_RS17570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GEOBRER4_RS17580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GEOBRER4_RS17585	COG1121	(ABC) transporter
GEOBRER4_RS17590	COG0803	Belongs to the bacterial solute-binding protein 9 family
GEOBRER4_RS17595	COG0735	belongs to the Fur family
GEOBRER4_RS17605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GEOBRER4_RS17610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GEOBRER4_RS17615	COG1492	cobalamin metabolic process
GEOBRER4_RS17640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GEOBRER4_RS17655	COG0612	Peptidase, M16
GEOBRER4_RS17660	COG1238	metal cluster binding
GEOBRER4_RS17665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GEOBRER4_RS17705	COG0655	NAD(P)H dehydrogenase (quinone) activity
GEOBRER4_RS17715	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS17725	COG0513	Belongs to the DEAD box helicase family
GEOBRER4_RS17735	COG4942	peptidase
GEOBRER4_RS17745	COG1136	(ABC) transporter
GEOBRER4_RS17745	COG0577	efflux transmembrane transporter activity
GEOBRER4_RS17805	COG2076	Multidrug Resistance protein
GEOBRER4_RS17810	COG0058	SHG alpha-glucan phosphorylase activity
GEOBRER4_RS17865	COG0590	tRNA wobble adenosine to inosine editing
GEOBRER4_RS17870	COG0864	Transcriptional regulator
GEOBRER4_RS17885	COG1047	Peptidyl-prolyl cis-trans
GEOBRER4_RS17890	COG0494	nUDIX hydrolase
GEOBRER4_RS17895	COG0564	pseudouridine synthase activity
GEOBRER4_RS17910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GEOBRER4_RS17920	COG0826	peptidase U32
GEOBRER4_RS17930	COG1368	sulfuric ester hydrolase activity
GEOBRER4_RS17940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GEOBRER4_RS17945	COG1121	(ABC) transporter
GEOBRER4_RS17955	COG0803	Belongs to the bacterial solute-binding protein 9 family
GEOBRER4_RS17965	COG1691	(AIR) carboxylase
GEOBRER4_RS17970	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GEOBRER4_RS17975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GEOBRER4_RS17980	COG1058	Belongs to the CinA family
GEOBRER4_RS17980	COG1546	Belongs to the CinA family
GEOBRER4_RS17985	COG5002	protein histidine kinase activity
GEOBRER4_RS17990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GEOBRER4_RS18000	COG2137	regulation of response to DNA damage stimulus
GEOBRER4_RS18010	COG5002	protein histidine kinase activity
GEOBRER4_RS18015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GEOBRER4_RS18020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GEOBRER4_RS18025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GEOBRER4_RS18040	COG0137	argininosuccinate synthase activity
GEOBRER4_RS18055	COG0165	Argininosuccinate lyase
GEOBRER4_RS18065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GEOBRER4_RS18070	COG0154	amidase activity
GEOBRER4_RS18075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GEOBRER4_RS18080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GEOBRER4_RS18085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GEOBRER4_RS18090	COG0824	Thioesterase
GEOBRER4_RS18095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GEOBRER4_RS18100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GEOBRER4_RS18130	COG1918	ferrous iron import across plasma membrane
GEOBRER4_RS18130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GEOBRER4_RS18190	COG0492	ferredoxin-NADP+ reductase activity
GEOBRER4_RS18205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GEOBRER4_RS18280	COG0514	ATP-dependent DNA helicase (RecQ)
GEOBRER4_RS18315	COG1469	GTP cyclohydrolase I activity
GEOBRER4_RS18320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GEOBRER4_RS18330	COG0358	DNA primase activity
GEOBRER4_RS18340	COG1610	YqeY-like protein
GEOBRER4_RS18350	COG0140	phosphoribosyl-ATP diphosphatase activity
GEOBRER4_RS18355	COG0107	imidazoleglycerol-phosphate synthase activity
GEOBRER4_RS18360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GEOBRER4_RS18365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GEOBRER4_RS18370	COG0131	Imidazoleglycerol-phosphate dehydratase
GEOBRER4_RS18375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GEOBRER4_RS18385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GEOBRER4_RS18395	COG2890	protein-(glutamine-N5) methyltransferase activity
GEOBRER4_RS18405	COG3872	metal-dependent enzyme
GEOBRER4_RS18410	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GEOBRER4_RS18415	COG0254	rRNA binding
GEOBRER4_RS18425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GEOBRER4_RS18430	COG1408	metallophosphoesterase
GEOBRER4_RS18455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GEOBRER4_RS18465	COG1086	Polysaccharide biosynthesis protein
GEOBRER4_RS18470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GEOBRER4_RS18475	COG1083	cytidylyl-transferase
GEOBRER4_RS18490	COG2089	acid synthase
GEOBRER4_RS18505	COG1516	flagellar protein fliS
GEOBRER4_RS18510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GEOBRER4_RS18515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GEOBRER4_RS18530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GEOBRER4_RS18535	COG1256	bacterial-type flagellum assembly
GEOBRER4_RS18560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GEOBRER4_RS18575	COG4786	Flagellar basal body rod
GEOBRER4_RS18580	COG1191	sigma factor activity
GEOBRER4_RS18590	COG1419	protein localization to endoplasmic reticulum
GEOBRER4_RS18595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GEOBRER4_RS18605	COG1242	4 iron, 4 sulfur cluster binding
GEOBRER4_RS18610	COG1199	ATP-dependent helicase activity
GEOBRER4_RS18615	COG1040	competence protein
GEOBRER4_RS18630	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GEOBRER4_RS18635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GEOBRER4_RS18640	COG0799	negative regulation of ribosome biogenesis
GEOBRER4_RS18645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GEOBRER4_RS18650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GEOBRER4_RS18655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GEOBRER4_RS18665	COG0306	phosphate transporter
GEOBRER4_RS18670	COG1392	Phosphate transport regulator
GEOBRER4_RS18675	COG1968	undecaprenyl-diphosphatase activity
GEOBRER4_RS18750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GEOBRER4_RS18760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GEOBRER4_RS18765	COG0215	cysteine-tRNA ligase activity
GEOBRER4_RS18790	COG1122	ATPase activity
GEOBRER4_RS18805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GEOBRER4_RS18810	COG1797	cobyrinic acid a,c-diamide synthase activity
GEOBRER4_RS18820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GEOBRER4_RS18825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GEOBRER4_RS18835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GEOBRER4_RS18850	COG3852	Histidine kinase
GEOBRER4_RS18865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GEOBRER4_RS18870	COG4791	protein targeting
GEOBRER4_RS18875	COG1987	bacterial-type flagellum assembly
GEOBRER4_RS18880	COG1338	Plays a role in the flagellum-specific transport system
GEOBRER4_RS18905	COG4786	Flagellar basal body rod
GEOBRER4_RS18915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GEOBRER4_RS18935	COG1157	protein secretion by the type III secretion system
GEOBRER4_RS18945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GEOBRER4_RS18950	COG1766	The M ring may be actively involved in energy transduction
GEOBRER4_RS18955	COG1677	Flagellar hook-basal body complex protein FliE
GEOBRER4_RS18960	COG1558	bacterial-type flagellum-dependent cell motility
GEOBRER4_RS18965	COG1815	bacterial-type flagellum-dependent cell motility
GEOBRER4_RS18985	COG0745	RESPONSE REGULATOR receiver
GEOBRER4_RS18990	COG5002	protein histidine kinase activity
GEOBRER4_RS18995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GEOBRER4_RS19015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GEOBRER4_RS19040	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GEOBRER4_RS19075	COG0463	Glycosyl transferase, family 2
GEOBRER4_RS19085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GEOBRER4_RS19100	COG0288	reversible hydration of carbon dioxide
GEOBRER4_RS19115	COG1881	PFAM PEBP family protein
GEOBRER4_RS19145	COG1454	alcohol dehydrogenase
GEOBRER4_RS19160	COG0840	transmembrane signaling receptor activity
GEOBRER4_RS19180	COG3259	Nickel-dependent hydrogenase
GEOBRER4_RS19185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS19195	COG0835	chemotaxis
GEOBRER4_RS19230	COG0427	acetyl-CoA hydrolase
GEOBRER4_RS19255	COG0700	Nucleoside recognition
GEOBRER4_RS19260	COG2715	membrane protein required for spore maturation
GEOBRER4_RS19265	COG1619	proteins homologs of microcin C7 resistance protein MccF
GEOBRER4_RS19275	COG1272	protein, Hemolysin III
GEOBRER4_RS19290	COG1007	ATP synthesis coupled electron transport
GEOBRER4_RS19305	COG0713	ATP synthesis coupled electron transport
GEOBRER4_RS19310	COG0839	Belongs to the complex I subunit 6 family
GEOBRER4_RS19315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS19320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GEOBRER4_RS19340	COG0649	NAD binding
GEOBRER4_RS19345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS19350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS19355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GEOBRER4_RS19360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GEOBRER4_RS19365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GEOBRER4_RS19380	COG0356	it plays a direct role in the translocation of protons across the membrane
GEOBRER4_RS19385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GEOBRER4_RS19395	COG0697	spore germination
GEOBRER4_RS19410	COG0084	hydrolase, TatD family'
GEOBRER4_RS19420	COG0741	lytic transglycosylase activity
GEOBRER4_RS19430	COG0835	chemotaxis
GEOBRER4_RS19435	COG2198	Histidine kinase
GEOBRER4_RS19435	COG0784	Response regulator, receiver
GEOBRER4_RS19435	COG0643	Histidine kinase
GEOBRER4_RS19450	COG2201	protein-glutamate methylesterase activity
GEOBRER4_RS19470	COG0534	Mate efflux family protein
GEOBRER4_RS19475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GEOBRER4_RS19480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GEOBRER4_RS19485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GEOBRER4_RS19490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GEOBRER4_RS19495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GEOBRER4_RS19500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GEOBRER4_RS19505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GEOBRER4_RS19510	COG1475	DNA binding
GEOBRER4_RS19515	COG1192	Involved in chromosome partitioning
GEOBRER4_RS19530	COG0724	RNA recognition motif
GEOBRER4_RS19535	COG0322	excinuclease ABC activity
GEOBRER4_RS19540	COG1100	Small GTP-binding protein
GEOBRER4_RS19550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GEOBRER4_RS19575	COG0242	peptide deformylase activity
GEOBRER4_RS19580	COG3830	Belongs to the UPF0237 family
GEOBRER4_RS19585	COG1674	ftsk spoiiie
GEOBRER4_RS19590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GEOBRER4_RS19610	COG0629	single-stranded DNA binding
GEOBRER4_RS19640	COG1247	-acetyltransferase
GEOBRER4_RS19650	COG1376	ErfK ybiS ycfS ynhG family protein
GEOBRER4_RS19660	COG3034	peptidoglycan biosynthetic process
GEOBRER4_RS19665	COG0534	Mate efflux family protein
GEOBRER4_RS19675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GEOBRER4_RS19690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GEOBRER4_RS19700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GEOBRER4_RS19705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GEOBRER4_RS19710	COG4191	Histidine kinase
GEOBRER4_RS19725	COG2703	oxygen carrier activity
GEOBRER4_RS19730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GEOBRER4_RS19775	COG0723	plastoquinol--plastocyanin reductase activity
GEOBRER4_RS19805	COG3746	phosphate-selective porin O and P
GEOBRER4_RS19815	COG0583	DNA-binding transcription factor activity
GEOBRER4_RS19825	COG2814	Major facilitator Superfamily
GEOBRER4_RS19830	COG1053	succinate dehydrogenase
GEOBRER4_RS19840	COG2204	response regulator
GEOBRER4_RS19845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GEOBRER4_RS19845	COG4191	Histidine kinase
GEOBRER4_RS19860	COG1199	ATP-dependent helicase activity
GEOBRER4_RS19880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GEOBRER4_RS19895	COG0693	protein deglycase activity
GEOBRER4_RS19900	COG0436	Aminotransferase
GEOBRER4_RS19905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GEOBRER4_RS19910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GEOBRER4_RS19920	COG0357	Ribosomal RNA small subunit methyltransferase G
GEOBRER4_RS19925	COG0445	tRNA wobble uridine modification
GEOBRER4_RS19935	COG0706	membrane insertase activity
GEOBRER4_RS19940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane