locus-tag	class	description
GM18_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GM18_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GM18_RS00025	COG0187	DNA topoisomerase II activity
GM18_RS00040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GM18_RS00045	COG5002	protein histidine kinase activity
GM18_RS00050	COG5002	protein histidine kinase activity
GM18_RS00055	COG3852	Histidine kinase
GM18_RS00075	COG0535	radical SAM domain protein
GM18_RS00080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GM18_RS00085	COG0598	Magnesium transport protein CorA
GM18_RS00095	COG2827	Endonuclease containing a URI domain
GM18_RS00100	COG0493	'glutamate synthase
GM18_RS00100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM18_RS00105	COG0543	2 iron, 2 sulfur cluster binding
GM18_RS00135	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GM18_RS00155	COG1132	(ABC) transporter
GM18_RS00180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GM18_RS00200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GM18_RS00215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GM18_RS00220	COG0109	protoheme IX farnesyltransferase activity
GM18_RS00225	COG0156	8-amino-7-oxononanoate synthase activity
GM18_RS00230	COG1063	alcohol dehydrogenase
GM18_RS00240	COG2085	NADP oxidoreductase coenzyme F420-dependent
GM18_RS00250	COG3385	transposase activity
GM18_RS00265	COG3657	addiction module killer protein
GM18_RS00310	COG4106	trans-aconitate 2-methyltransferase activity
GM18_RS00315	COG0500	methyltransferase
GM18_RS00330	COG0348	domain, Protein
GM18_RS00335	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS00340	COG0243	molybdopterin cofactor binding
GM18_RS00350	COG2205	protein histidine kinase activity
GM18_RS00365	COG0745	RESPONSE REGULATOR receiver
GM18_RS00385	COG2201	protein-glutamate methylesterase activity
GM18_RS00390	COG0643	Histidine kinase
GM18_RS00390	COG2198	Histidine kinase
GM18_RS00390	COG0784	Response regulator, receiver
GM18_RS00395	COG0840	transmembrane signaling receptor activity
GM18_RS00400	COG0835	chemotaxis
GM18_RS00405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GM18_RS00415	COG2234	aminopeptidase activity
GM18_RS00420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM18_RS00425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GM18_RS00445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GM18_RS00450	COG1047	Peptidyl-prolyl cis-trans
GM18_RS00465	COG3132	Protein of unknown function, DUF480
GM18_RS00485	COG0531	amino acid
GM18_RS00490	COG2205	protein histidine kinase activity
GM18_RS00495	COG0745	RESPONSE REGULATOR receiver
GM18_RS00510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GM18_RS00545	COG2132	Multicopper oxidase
GM18_RS00550	COG4771	TonB-dependent receptor
GM18_RS00565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS00570	COG2326	polyphosphate kinase activity
GM18_RS00605	COG0366	Alpha amylase catalytic
GM18_RS00620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GM18_RS00640	COG0745	RESPONSE REGULATOR receiver
GM18_RS00650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS00655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM18_RS00660	COG0784	Response regulator, receiver
GM18_RS00665	COG0556	nucleotide-excision repair
GM18_RS00685	COG0450	alkyl hydroperoxide reductase
GM18_RS00715	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GM18_RS00725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GM18_RS00730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GM18_RS00735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GM18_RS00745	COG1007	ATP synthesis coupled electron transport
GM18_RS00755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GM18_RS00760	COG0713	ATP synthesis coupled electron transport
GM18_RS00770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS00780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GM18_RS00785	COG1034	ATP synthesis coupled electron transport
GM18_RS00790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GM18_RS00800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS00800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS00800	COG0649	NAD binding
GM18_RS00805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS00830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GM18_RS00845	COG0484	heat shock protein binding
GM18_RS00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS00855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS00875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GM18_RS00880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GM18_RS00885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GM18_RS00890	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM18_RS00890	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM18_RS00890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM18_RS00890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GM18_RS00895	COG1278	Cold shock
GM18_RS00905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GM18_RS00930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GM18_RS00980	COG0741	lytic transglycosylase activity
GM18_RS00985	COG3132	Protein of unknown function, DUF480
GM18_RS00995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS01000	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GM18_RS01015	COG0513	Belongs to the DEAD box helicase family
GM18_RS01020	COG0426	domain, Protein
GM18_RS01025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GM18_RS01035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM18_RS01045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GM18_RS01050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GM18_RS01095	COG0393	Putative heavy-metal-binding
GM18_RS01110	COG0717	Belongs to the dCTP deaminase family
GM18_RS01115	COG0784	Response regulator, receiver
GM18_RS01115	COG5002	protein histidine kinase activity
GM18_RS01135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GM18_RS01140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GM18_RS01155	COG0482	sulfurtransferase activity
GM18_RS01160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS01170	COG0436	Aminotransferase
GM18_RS01175	COG2267	carboxylic ester hydrolase activity
GM18_RS01225	COG0745	RESPONSE REGULATOR receiver
GM18_RS01330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GM18_RS01335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GM18_RS01340	COG0163	prenyltransferase activity
GM18_RS01345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GM18_RS01350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GM18_RS01355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM18_RS01375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GM18_RS01380	COG2264	protein methyltransferase activity
GM18_RS01385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GM18_RS01390	COG0745	RESPONSE REGULATOR receiver
GM18_RS01395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM18_RS01400	COG1234	tRNA 3'-trailer cleavage
GM18_RS01415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GM18_RS01420	COG0459	protein refolding
GM18_RS01450	COG2719	SpoVR family
GM18_RS01465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GM18_RS01470	COG0045	succinate-CoA ligase (ADP-forming) activity
GM18_RS01485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GM18_RS01490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GM18_RS01495	COG1796	DNA polymerase
GM18_RS01495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GM18_RS01505	COG0598	Magnesium transport protein CorA
GM18_RS01510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GM18_RS01515	COG0308	aminopeptidase N
GM18_RS01535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS01540	COG4191	Histidine kinase
GM18_RS01545	COG1100	Small GTP-binding protein
GM18_RS01570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GM18_RS01580	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GM18_RS01585	COG1811	Na channel or pump
GM18_RS01590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GM18_RS01600	COG0646	methionine synthase
GM18_RS01600	COG1410	methionine synthase
GM18_RS01610	COG3959	Transketolase, thiamine diphosphate binding domain
GM18_RS01615	COG3958	Transketolase
GM18_RS01625	COG4191	Histidine kinase
GM18_RS01630	COG2204	response regulator
GM18_RS01650	COG3328	transposase activity
GM18_RS01670	COG3387	PFAM Glycoside hydrolase 15-related
GM18_RS01680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GM18_RS01700	COG2885	chlorophyll binding
GM18_RS01710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS01755	COG1733	regulation of RNA biosynthetic process
GM18_RS01770	COG0204	Acyl-transferase
GM18_RS01770	COG0318	PFAM AMP-dependent synthetase and ligase
GM18_RS01785	COG2944	sequence-specific DNA binding
GM18_RS01800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM18_RS01855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GM18_RS01865	COG2885	chlorophyll binding
GM18_RS01870	COG0631	protein serine/threonine phosphatase activity
GM18_RS01900	COG1959	2 iron, 2 sulfur cluster binding
GM18_RS01915	COG0427	acetyl-CoA hydrolase
GM18_RS01925	COG1607	acyl-coa hydrolase
GM18_RS01930	COG0247	lactate metabolic process
GM18_RS01930	COG2181	nitrate reductase activity
GM18_RS01940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS01950	COG0183	Belongs to the thiolase family
GM18_RS01955	COG1024	Enoyl-CoA hydratase
GM18_RS01960	COG1250	3-hydroxyacyl-CoA dehydrogenase
GM18_RS01965	COG1960	acyl-CoA dehydrogenase activity
GM18_RS01975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM18_RS01980	COG2223	nitrite transmembrane transporter activity
GM18_RS02000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS02005	COG2181	nitrate reductase activity
GM18_RS02005	COG0247	lactate metabolic process
GM18_RS02045	COG3385	transposase activity
GM18_RS02110	COG0321	lipoyl(octanoyl) transferase activity
GM18_RS02110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GM18_RS02125	COG0596	Alpha beta hydrolase
GM18_RS02135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GM18_RS02140	COG1074	ATP-dependent DNA helicase activity
GM18_RS02145	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GM18_RS02160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GM18_RS02165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GM18_RS02170	COG2084	Dehydrogenase
GM18_RS02175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GM18_RS02190	COG1490	D-aminoacyl-tRNA deacylase activity
GM18_RS02200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GM18_RS02220	COG1959	2 iron, 2 sulfur cluster binding
GM18_RS02225	COG1606	tRNA processing
GM18_RS02230	COG0071	Belongs to the small heat shock protein (HSP20) family
GM18_RS02235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GM18_RS02235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GM18_RS02250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS02255	COG2840	Smr protein MutS2
GM18_RS02260	COG1940	carbohydrate kinase activity
GM18_RS02270	COG0011	TIGRFAM Protein of
GM18_RS02295	COG0725	ABC transporter, periplasmic molybdate-binding protein
GM18_RS02305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GM18_RS02310	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GM18_RS02315	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GM18_RS02325	COG2197	response regulator
GM18_RS02340	COG0842	Transport permease protein
GM18_RS02345	COG0842	Transport permease protein
GM18_RS02350	COG1131	(ABC) transporter
GM18_RS02355	COG1131	(ABC) transporter
GM18_RS02360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM18_RS02380	COG0528	UMP kinase activity
GM18_RS02400	COG2026	Addiction module toxin, RelE StbE family
GM18_RS02415	COG1970	mechanosensitive ion channel activity
GM18_RS02455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GM18_RS02460	COG0509	glycine decarboxylation via glycine cleavage system
GM18_RS02465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM18_RS02470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM18_RS02475	COG0095	Lipoate-protein ligase
GM18_RS02485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GM18_RS02510	COG3385	transposase activity
GM18_RS02550	COG2826	transposase and inactivated derivatives, IS30 family
GM18_RS02640	COG0582	viral genome integration into host DNA
GM18_RS02660	COG0864	Transcriptional regulator
GM18_RS02675	COG1047	Peptidyl-prolyl cis-trans
GM18_RS02685	COG0564	pseudouridine synthase activity
GM18_RS02695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GM18_RS02700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GM18_RS02710	COG0826	peptidase U32
GM18_RS02720	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GM18_RS02725	COG1238	metal cluster binding
GM18_RS02730	COG0612	Peptidase, M16
GM18_RS02745	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GM18_RS02770	COG1492	cobalamin metabolic process
GM18_RS02775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GM18_RS02790	COG0735	belongs to the Fur family
GM18_RS02795	COG0803	Belongs to the bacterial solute-binding protein 9 family
GM18_RS02795	COG3443	Belongs to the bacterial solute-binding protein 9 family
GM18_RS02800	COG1121	(ABC) transporter
GM18_RS02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GM18_RS02810	COG5001	Diguanylate cyclase
GM18_RS02810	COG5002	protein histidine kinase activity
GM18_RS02815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GM18_RS02825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GM18_RS02825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GM18_RS02830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GM18_RS02835	COG0494	nUDIX hydrolase
GM18_RS02855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GM18_RS02860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GM18_RS02865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM18_RS02885	COG2885	chlorophyll binding
GM18_RS02890	COG0823	Involved in the tonB-independent uptake of proteins
GM18_RS02910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM18_RS02915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GM18_RS02920	COG1420	regulation of RNA biosynthetic process
GM18_RS02925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GM18_RS02930	COG0443	Heat shock 70 kDa protein
GM18_RS02935	COG0484	heat shock protein binding
GM18_RS02945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GM18_RS02950	COG0588	phosphoglycerate mutase activity
GM18_RS03005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GM18_RS03015	COG1032	radical SAM domain protein
GM18_RS03020	COG1032	radical SAM domain protein
GM18_RS03030	COG0577	efflux transmembrane transporter activity
GM18_RS03035	COG0577	efflux transmembrane transporter activity
GM18_RS03035	COG1136	(ABC) transporter
GM18_RS03040	COG1136	(ABC) transporter
GM18_RS03115	COG0463	Glycosyl transferase, family 2
GM18_RS03130	COG1032	radical SAM domain protein
GM18_RS03140	COG1032	radical SAM domain protein
GM18_RS03155	COG0642	Histidine kinase
GM18_RS03165	COG0745	RESPONSE REGULATOR receiver
GM18_RS03185	COG2204	response regulator
GM18_RS03195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GM18_RS03200	COG0352	thiamine-phosphate diphosphorylase activity
GM18_RS03200	COG0351	phosphomethylpyrimidine kinase
GM18_RS03205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GM18_RS03220	COG0138	bifunctional purine biosynthesis protein purh
GM18_RS03225	COG0151	Belongs to the GarS family
GM18_RS03240	COG1333	cytochrome c biogenesis protein
GM18_RS03245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GM18_RS03260	COG0463	Glycosyl transferase, family 2
GM18_RS03305	COG0297	glycogen (starch) synthase activity
GM18_RS03310	COG1215	transferase activity, transferring glycosyl groups
GM18_RS03345	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GM18_RS03370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GM18_RS03375	COG0228	four-way junction DNA binding
GM18_RS03390	COG0336	Belongs to the RNA methyltransferase TrmD family
GM18_RS03395	COG0336	Belongs to the RNA methyltransferase TrmD family
GM18_RS03395	COG4752	Belongs to the RNA methyltransferase TrmD family
GM18_RS03400	COG0335	large ribosomal subunit rRNA binding
GM18_RS03405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GM18_RS03420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM18_RS03420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM18_RS03430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GM18_RS03435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GM18_RS03440	COG0166	Belongs to the GPI family
GM18_RS03450	COG0142	geranyltranstransferase activity
GM18_RS03460	COG2204	response regulator
GM18_RS03465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM18_RS03470	COG0785	Cytochrome C biogenesis protein
GM18_RS03490	COG0795	lipopolysaccharide-transporting ATPase activity
GM18_RS03510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GM18_RS03535	COG0564	pseudouridine synthase activity
GM18_RS03545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM18_RS03580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS03585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GM18_RS03610	COG0697	spore germination
GM18_RS03615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GM18_RS03630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GM18_RS03640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GM18_RS03665	COG1451	nucleotide metabolic process
GM18_RS03670	COG0156	8-amino-7-oxononanoate synthase activity
GM18_RS03675	COG2267	carboxylic ester hydrolase activity
GM18_RS03680	COG2226	methyltransferase
GM18_RS03685	COG0488	(ABC) transporter
GM18_RS03695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GM18_RS03705	COG1136	(ABC) transporter
GM18_RS03720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM18_RS03735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM18_RS03740	COG1132	(ABC) transporter
GM18_RS03750	COG1519	Transferase
GM18_RS03755	COG1663	tetraacyldisaccharide 4'-kinase activity
GM18_RS03760	COG0859	PFAM glycosyl transferase family 9
GM18_RS03765	COG1086	Polysaccharide biosynthesis protein
GM18_RS03770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GM18_RS03775	COG1083	cytidylyl-transferase
GM18_RS03785	COG2089	acid synthase
GM18_RS03810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GM18_RS03810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GM18_RS03815	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GM18_RS03820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS03835	COG1137	ATPase activity
GM18_RS03840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GM18_RS03850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GM18_RS03855	COG1660	Displays ATPase and GTPase activities
GM18_RS03865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GM18_RS03870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GM18_RS03905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM18_RS03940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GM18_RS03940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GM18_RS03955	COG2204	response regulator
GM18_RS03995	COG3344	reverse transcriptase
GM18_RS04005	COG2226	methyltransferase
GM18_RS04010	COG2226	methyltransferase
GM18_RS04020	COG0791	NLP P60 protein
GM18_RS04020	COG1388	LysM domain
GM18_RS04040	COG5000	phosphorelay sensor kinase activity
GM18_RS04045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GM18_RS04050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GM18_RS04060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS04065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GM18_RS04075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GM18_RS04080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM18_RS04085	COG0473	3-isopropylmalate dehydrogenase activity
GM18_RS04105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GM18_RS04110	COG0101	tRNA pseudouridine synthase activity
GM18_RS04115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GM18_RS04125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GM18_RS04130	COG1032	radical SAM domain protein
GM18_RS04165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GM18_RS04185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GM18_RS04195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GM18_RS04200	COG0222	ribosome binding
GM18_RS04205	COG0085	RNA polymerase activity
GM18_RS04210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GM18_RS04215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GM18_RS04220	COG0049	tRNA binding
GM18_RS04225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM18_RS04235	COG0051	transcription antitermination factor activity, RNA binding
GM18_RS04240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GM18_RS04245	COG0088	Forms part of the polypeptide exit tunnel
GM18_RS04250	COG0089	rRNA binding
GM18_RS04255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GM18_RS04260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GM18_RS04265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GM18_RS04270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GM18_RS04275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GM18_RS04280	COG0255	Belongs to the universal ribosomal protein uL29 family
GM18_RS04285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GM18_RS04290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GM18_RS04295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GM18_RS04300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GM18_RS04305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GM18_RS04310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GM18_RS04315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GM18_RS04320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GM18_RS04325	COG1841	ribosomal large subunit assembly
GM18_RS04330	COG0200	Binds to the 23S rRNA
GM18_RS04340	COG0563	adenylate kinase activity
GM18_RS04350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GM18_RS04355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GM18_RS04360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GM18_RS04365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GM18_RS04370	COG0202	RNA polymerase activity
GM18_RS04375	COG0203	ribosomal protein L17
GM18_RS04380	COG1196	nuclear chromosome segregation
GM18_RS04390	COG0552	protein localization to endoplasmic reticulum
GM18_RS04400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GM18_RS04410	COG1692	metallophosphoesterase
GM18_RS04415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GM18_RS04445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM18_RS04455	COG1741	Belongs to the pirin family
GM18_RS04460	COG2885	chlorophyll binding
GM18_RS04460	COG3047	cAMP biosynthetic process
GM18_RS04480	COG2226	methyltransferase
GM18_RS04490	COG3424	synthase
GM18_RS04495	COG1032	radical SAM domain protein
GM18_RS04500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GM18_RS04510	COG1151	hydroxylamine reductase activity
GM18_RS04525	COG2814	Major facilitator Superfamily
GM18_RS04530	COG0583	DNA-binding transcription factor activity
GM18_RS04535	COG2201	protein-glutamate methylesterase activity
GM18_RS04540	COG0745	RESPONSE REGULATOR receiver
GM18_RS04550	COG3290	protein histidine kinase activity
GM18_RS04550	COG0840	transmembrane signaling receptor activity
GM18_RS04555	COG2201	protein-glutamate methylesterase activity
GM18_RS04565	COG0840	transmembrane signaling receptor activity
GM18_RS04565	COG0840	transmembrane signaling receptor activity
GM18_RS04570	COG0835	chemotaxis
GM18_RS04575	COG2198	Histidine kinase
GM18_RS04575	COG0643	Histidine kinase
GM18_RS04585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM18_RS04590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM18_RS04595	COG0673	inositol 2-dehydrogenase activity
GM18_RS04620	COG3409	Peptidoglycan-binding domain 1 protein
GM18_RS04620	COG3267	Type II secretory pathway component ExeA
GM18_RS04665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM18_RS04685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GM18_RS04690	COG0723	plastoquinol--plastocyanin reductase activity
GM18_RS04710	COG4191	Histidine kinase
GM18_RS04830	COG0463	Glycosyl transferase, family 2
GM18_RS04835	COG0438	transferase activity, transferring glycosyl groups
GM18_RS04850	COG2337	Toxic component of a toxin-antitoxin (TA) module
GM18_RS04865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GM18_RS04890	COG3754	Rhamnan synthesis protein F
GM18_RS04905	COG0438	transferase activity, transferring glycosyl groups
GM18_RS04920	COG0490	domain, Protein
GM18_RS04920	COG0471	metal ion transport
GM18_RS04950	COG1682	transport, permease protein
GM18_RS04990	COG1216	Glycosyl transferase, family 2
GM18_RS05030	COG0438	transferase activity, transferring glycosyl groups
GM18_RS05035	COG4191	Histidine kinase
GM18_RS05055	COG2223	nitrite transmembrane transporter activity
GM18_RS05085	COG0730	response to heat
GM18_RS05140	COG1522	sequence-specific DNA binding
GM18_RS05145	COG0686	Belongs to the AlaDH PNT family
GM18_RS05155	COG4206	TonB-dependent receptor
GM18_RS05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS05230	COG2197	response regulator
GM18_RS05275	COG0697	spore germination
GM18_RS05295	COG0288	reversible hydration of carbon dioxide
GM18_RS05330	COG3344	reverse transcriptase
GM18_RS05345	COG3344	reverse transcriptase
GM18_RS05355	COG3706	GGDEF domain
GM18_RS05370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GM18_RS05395	COG2032	superoxide dismutase activity
GM18_RS05405	COG1846	Transcriptional regulator
GM18_RS05430	COG4191	Histidine kinase
GM18_RS05430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM18_RS05450	COG0765	amino acid transport
GM18_RS05455	COG0765	amino acid transport
GM18_RS05470	COG2197	response regulator
GM18_RS05515	COG3409	Peptidoglycan-binding domain 1 protein
GM18_RS05515	COG3267	Type II secretory pathway component ExeA
GM18_RS05525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GM18_RS05530	COG1794	racemase activity, acting on amino acids and derivatives
GM18_RS05570	COG2217	Heavy metal translocating P-type atpase
GM18_RS05600	COG3278	Belongs to the heme-copper respiratory oxidase family
GM18_RS05605	COG1151	hydroxylamine reductase activity
GM18_RS05635	COG2010	Cytochrome c
GM18_RS05640	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GM18_RS05650	COG2861	carbohydrate metabolic process
GM18_RS05655	COG1192	Involved in chromosome partitioning
GM18_RS05660	COG1570	exodeoxyribonuclease VII activity
GM18_RS05665	COG1722	exodeoxyribonuclease VII activity
GM18_RS05675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GM18_RS05685	COG0736	holo-[acyl-carrier-protein] synthase activity
GM18_RS05690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GM18_RS05690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GM18_RS05700	COG0802	atpase or kinase
GM18_RS05710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM18_RS05720	COG1959	2 iron, 2 sulfur cluster binding
GM18_RS05725	COG1271	oxidase subunit
GM18_RS05730	COG1294	oxidase, subunit
GM18_RS05735	COG0544	peptidyl-prolyl cis-trans isomerase activity
GM18_RS05740	COG0740	serine-type endopeptidase activity
GM18_RS05745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GM18_RS05775	COG1216	Glycosyl transferase, family 2
GM18_RS05785	COG1459	type II secretion system
GM18_RS05790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS05830	COG2884	Cell division ATP-binding protein ftsE
GM18_RS05835	COG2177	Part of the ABC transporter FtsEX involved in
GM18_RS05845	COG0793	Belongs to the peptidase S41A family
GM18_RS05865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GM18_RS05880	COG1049	propionate catabolic process, 2-methylcitrate cycle
GM18_RS05895	COG1011	Hydrolase
GM18_RS05905	COG0779	Required for maturation of 30S ribosomal subunits
GM18_RS05910	COG0195	Participates in both transcription termination and antitermination
GM18_RS05920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GM18_RS05925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GM18_RS05940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GM18_RS05945	COG1185	polyribonucleotide nucleotidyltransferase activity
GM18_RS05950	COG0612	Peptidase, M16
GM18_RS05955	COG0756	dUTP diphosphatase activity
GM18_RS05965	COG0009	L-threonylcarbamoyladenylate synthase
GM18_RS05975	COG0720	synthase
GM18_RS05980	COG0602	queuosine metabolic process
GM18_RS05985	COG0714	Associated with various cellular activities
GM18_RS06010	COG0281	malic enzyme
GM18_RS06010	COG0280	phosphate acetyltransferase
GM18_RS06030	COG1379	DNA repair
GM18_RS06035	COG0789	Transcriptional regulator
GM18_RS06065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS06075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GM18_RS06090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GM18_RS06100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GM18_RS06105	COG0745	RESPONSE REGULATOR receiver
GM18_RS06110	COG5002	protein histidine kinase activity
GM18_RS06125	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GM18_RS06135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM18_RS06145	COG2414	aldehyde ferredoxin oxidoreductase
GM18_RS06150	COG1454	alcohol dehydrogenase
GM18_RS06155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS06175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS06180	COG2181	nitrate reductase activity
GM18_RS06180	COG0247	lactate metabolic process
GM18_RS06195	COG3344	reverse transcriptase
GM18_RS06235	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GM18_RS06240	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GM18_RS06275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GM18_RS06295	COG0667	Aldo Keto reductase
GM18_RS06305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GM18_RS06315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GM18_RS06345	COG4191	Histidine kinase
GM18_RS06345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM18_RS06375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GM18_RS06385	COG2161	toxin-antitoxin pair type II binding
GM18_RS06450	COG0840	transmembrane signaling receptor activity
GM18_RS06470	COG0789	Transcriptional regulator
GM18_RS06480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM18_RS06490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS06490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS06490	COG1703	isobutyryl-CoA mutase activity
GM18_RS06500	COG0006	proline dipeptidase activity
GM18_RS06505	COG0183	Belongs to the thiolase family
GM18_RS06510	COG1250	3-hydroxyacyl-CoA dehydrogenase
GM18_RS06515	COG1024	Enoyl-CoA hydratase
GM18_RS06520	COG1960	acyl-CoA dehydrogenase activity
GM18_RS06525	COG2181	nitrate reductase activity
GM18_RS06525	COG0247	lactate metabolic process
GM18_RS06555	COG0840	transmembrane signaling receptor activity
GM18_RS06575	COG4302	ethanolamine ammonia-lyase activity
GM18_RS06620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GM18_RS06625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GM18_RS06660	COG1131	(ABC) transporter
GM18_RS06675	COG3459	Glycosyltransferase 36 associated
GM18_RS06725	COG1872	DUF167
GM18_RS06745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GM18_RS06760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS06765	COG0247	lactate metabolic process
GM18_RS06765	COG2181	nitrate reductase activity
GM18_RS06775	COG0519	Catalyzes the synthesis of GMP from XMP
GM18_RS06795	COG0004	ammonium transporteR
GM18_RS06805	COG0483	inositol monophosphate 1-phosphatase activity
GM18_RS06825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM18_RS06840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM18_RS06865	COG2204	response regulator
GM18_RS06870	COG4191	Histidine kinase
GM18_RS06880	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GM18_RS06885	COG0653	protein targeting
GM18_RS06890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GM18_RS06900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM18_RS06910	COG0525	valine-tRNA ligase activity
GM18_RS06915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GM18_RS06920	COG4191	Histidine kinase
GM18_RS06925	COG2204	response regulator
GM18_RS06940	COG4968	Prepilin-type N-terminal cleavage methylation domain
GM18_RS07025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GM18_RS07030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GM18_RS07035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GM18_RS07050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GM18_RS07055	COG0006	proline dipeptidase activity
GM18_RS07060	COG0511	ligase activity, forming carbon-carbon bonds
GM18_RS07065	COG0439	Biotin carboxylase
GM18_RS07070	COG0509	glycine decarboxylation via glycine cleavage system
GM18_RS07075	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GM18_RS07085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM18_RS07095	COG1104	cysteine desulfurase activity
GM18_RS07100	COG1119	ATPase activity
GM18_RS07105	COG1201	RNA secondary structure unwinding
GM18_RS07120	COG1234	tRNA 3'-trailer cleavage
GM18_RS07160	COG0745	RESPONSE REGULATOR receiver
GM18_RS07165	COG0643	Histidine kinase
GM18_RS07165	COG2198	Histidine kinase
GM18_RS07175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GM18_RS07180	COG2201	protein-glutamate methylesterase activity
GM18_RS07185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GM18_RS07190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GM18_RS07195	COG0504	CTP synthase activity
GM18_RS07200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GM18_RS07210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GM18_RS07235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS07260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GM18_RS07265	COG0367	asparagine synthase
GM18_RS07305	COG0297	glycogen (starch) synthase activity
GM18_RS07350	COG0367	asparagine synthase
GM18_RS07355	COG0438	transferase activity, transferring glycosyl groups
GM18_RS07360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM18_RS07365	COG0110	maltose O-acetyltransferase activity
GM18_RS07370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GM18_RS07385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM18_RS07405	COG3385	transposase activity
GM18_RS07415	COG3409	Peptidoglycan-binding domain 1 protein
GM18_RS07415	COG3267	Type II secretory pathway component ExeA
GM18_RS07425	COG2983	Belongs to the UPF0260 family
GM18_RS07435	COG4251	negative regulation of phosphorylation
GM18_RS07440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM18_RS07445	COG1045	serine acetyltransferase
GM18_RS07450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GM18_RS07455	COG0793	Belongs to the peptidase S41A family
GM18_RS07465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM18_RS07470	COG5002	protein histidine kinase activity
GM18_RS07475	COG0745	RESPONSE REGULATOR receiver
GM18_RS07480	COG0318	PFAM AMP-dependent synthetase and ligase
GM18_RS07485	COG0006	proline dipeptidase activity
GM18_RS07495	COG2078	PFAM AMMECR1 domain protein
GM18_RS07495	COG3885	ferrous iron binding
GM18_RS07505	COG0105	UTP biosynthetic process
GM18_RS07515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GM18_RS07535	COG2204	response regulator
GM18_RS07545	COG3852	Histidine kinase
GM18_RS07555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GM18_RS07560	COG3481	metal-dependent phosphohydrolase, HD sub domain
GM18_RS07565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM18_RS07570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GM18_RS07590	COG0438	transferase activity, transferring glycosyl groups
GM18_RS07610	COG3842	ATPase activity
GM18_RS07620	COG1971	Probably functions as a manganese efflux pump
GM18_RS07630	COG4977	sequence-specific DNA binding
GM18_RS07635	COG1012	belongs to the aldehyde dehydrogenase family
GM18_RS07640	COG0822	iron-sulfur transferase activity
GM18_RS07645	COG0798	PFAM Bile acid sodium symporter
GM18_RS07650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GM18_RS07670	COG0704	Plays a role in the regulation of phosphate uptake
GM18_RS07675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GM18_RS07680	COG0581	inorganic phosphate transmembrane transporter activity
GM18_RS07685	COG0573	inorganic phosphate transmembrane transporter activity
GM18_RS07695	COG5002	protein histidine kinase activity
GM18_RS07700	COG0745	RESPONSE REGULATOR receiver
GM18_RS07705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GM18_RS07710	COG0704	Plays a role in the regulation of phosphate uptake
GM18_RS07810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM18_RS07815	COG0248	Ppx GppA phosphatase
GM18_RS07960	COG1216	Glycosyl transferase, family 2
GM18_RS07965	COG0297	glycogen (starch) synthase activity
GM18_RS07980	COG1649	PFAM Uncharacterised BCR, COG1649
GM18_RS07980	COG0726	polysaccharide deacetylase
GM18_RS07985	COG0438	transferase activity, transferring glycosyl groups
GM18_RS07990	COG0673	inositol 2-dehydrogenase activity
GM18_RS08010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM18_RS08035	COG0489	protein tyrosine kinase activity
GM18_RS08040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GM18_RS08045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GM18_RS08070	COG0596	Alpha beta hydrolase
GM18_RS08075	COG0318	PFAM AMP-dependent synthetase and ligase
GM18_RS08080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GM18_RS08130	COG0582	viral genome integration into host DNA
GM18_RS08150	COG0860	N-Acetylmuramoyl-L-alanine amidase
GM18_RS08155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GM18_RS08170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GM18_RS08180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GM18_RS08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GM18_RS08250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM18_RS08265	COG0489	protein tyrosine kinase activity
GM18_RS08270	COG3267	Type II secretory pathway component ExeA
GM18_RS08270	COG3409	Peptidoglycan-binding domain 1 protein
GM18_RS08305	COG1132	(ABC) transporter
GM18_RS08330	COG0438	transferase activity, transferring glycosyl groups
GM18_RS08350	COG0726	polysaccharide deacetylase
GM18_RS08370	COG1216	Glycosyl transferase, family 2
GM18_RS08400	COG4191	Histidine kinase
GM18_RS08405	COG2204	response regulator
GM18_RS08410	COG0318	PFAM AMP-dependent synthetase and ligase
GM18_RS08420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM18_RS08425	COG0367	asparagine synthase
GM18_RS08465	COG1959	2 iron, 2 sulfur cluster binding
GM18_RS08475	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GM18_RS08480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GM18_RS08485	COG4208	sulfate ABC transporter
GM18_RS08490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GM18_RS08505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GM18_RS08510	COG0741	lytic transglycosylase activity
GM18_RS08535	COG4974	Belongs to the 'phage' integrase family
GM18_RS08540	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GM18_RS08560	COG0481	GTPase activity
GM18_RS08565	COG0840	transmembrane signaling receptor activity
GM18_RS08580	COG1136	(ABC) transporter
GM18_RS08585	COG0577	efflux transmembrane transporter activity
GM18_RS08585	COG1136	(ABC) transporter
GM18_RS08600	COG0288	reversible hydration of carbon dioxide
GM18_RS08605	COG0280	phosphate acetyltransferase
GM18_RS08605	COG0281	malic enzyme
GM18_RS08620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GM18_RS08625	COG0742	ribosomal rna small subunit methyltransferase
GM18_RS08630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GM18_RS08635	COG2703	oxygen carrier activity
GM18_RS08640	COG1534	Rna-binding protein
GM18_RS08645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GM18_RS08650	COG0540	Belongs to the ATCase OTCase family
GM18_RS08655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GM18_RS08660	COG0505	Belongs to the CarA family
GM18_RS08675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GM18_RS08685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GM18_RS08700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GM18_RS08705	COG0390	transport system, permease component
GM18_RS08725	COG0765	amino acid transport
GM18_RS08750	COG0861	Integral membrane protein TerC family
GM18_RS08755	COG1615	UPF0182 protein
GM18_RS08805	COG0442	prolyl-tRNA aminoacylation
GM18_RS08810	COG0733	neurotransmitter:sodium symporter activity
GM18_RS08815	COG2962	Rard protein
GM18_RS08830	COG3829	transcription factor binding
GM18_RS08830	COG3290	protein histidine kinase activity
GM18_RS08835	COG1012	belongs to the aldehyde dehydrogenase family
GM18_RS08840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GM18_RS08850	COG2204	response regulator
GM18_RS08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GM18_RS08880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GM18_RS08885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GM18_RS08895	COG0543	2 iron, 2 sulfur cluster binding
GM18_RS08900	COG0167	dihydroorotate dehydrogenase activity
GM18_RS08910	COG0583	DNA-binding transcription factor activity
GM18_RS08915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GM18_RS08920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GM18_RS08925	COG2208	phosphoserine phosphatase activity
GM18_RS08945	COG4206	TonB-dependent receptor
GM18_RS08970	COG2201	protein-glutamate methylesterase activity
GM18_RS08975	COG0643	Histidine kinase
GM18_RS08975	COG0784	Response regulator, receiver
GM18_RS08975	COG2198	Histidine kinase
GM18_RS08990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GM18_RS09005	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM18_RS09010	COG0739	heme binding
GM18_RS09015	COG0778	Nitroreductase
GM18_RS09020	COG1309	transcriptional regulator
GM18_RS09030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM18_RS09035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS09055	COG2853	Lipoprotein
GM18_RS09080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM18_RS09085	COG0577	efflux transmembrane transporter activity
GM18_RS09085	COG1136	(ABC) transporter
GM18_RS09090	COG0577	efflux transmembrane transporter activity
GM18_RS09090	COG1136	(ABC) transporter
GM18_RS09095	COG0534	Mate efflux family protein
GM18_RS09100	COG0175	sulfate reduction
GM18_RS09105	COG0175	sulfate reduction
GM18_RS09110	COG2895	sulfate adenylyltransferase (ATP) activity
GM18_RS09135	COG2207	Transcriptional regulator
GM18_RS09140	COG0667	Aldo Keto reductase
GM18_RS09150	COG2414	aldehyde ferredoxin oxidoreductase
GM18_RS09155	COG1064	alcohol dehydrogenase
GM18_RS09195	COG4191	Histidine kinase
GM18_RS09200	COG2204	response regulator
GM18_RS09215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GM18_RS09225	COG1104	cysteine desulfurase activity
GM18_RS09255	COG2414	aldehyde ferredoxin oxidoreductase
GM18_RS09260	COG1160	GTP binding
GM18_RS09265	COG1027	Aspartate ammonia-lyase
GM18_RS09270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GM18_RS09275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GM18_RS09285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GM18_RS09285	COG2111	Na H antiporter
GM18_RS09290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GM18_RS09295	COG3260	NADH ubiquinone oxidoreductase 20
GM18_RS09315	COG0375	protein maturation
GM18_RS09320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GM18_RS09345	COG0298	carbon dioxide binding
GM18_RS09350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM18_RS09360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GM18_RS09365	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GM18_RS09370	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GM18_RS09380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM18_RS09400	COG1433	Dinitrogenase iron-molybdenum cofactor
GM18_RS09400	COG0535	radical SAM domain protein
GM18_RS09405	COG0454	-acetyltransferase
GM18_RS09405	COG0456	acetyltransferase
GM18_RS09415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS09420	COG0247	lactate metabolic process
GM18_RS09420	COG2181	nitrate reductase activity
GM18_RS09450	COG0330	HflC and HflK could
GM18_RS09460	COG3344	reverse transcriptase
GM18_RS09475	COG2202	Pas domain
GM18_RS09475	COG2205	protein histidine kinase activity
GM18_RS09515	COG0149	triose-phosphate isomerase activity
GM18_RS09520	COG0126	phosphoglycerate kinase activity
GM18_RS09530	COG2205	protein histidine kinase activity
GM18_RS09535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GM18_RS09540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GM18_RS09545	COG0668	transmembrane transport
GM18_RS09550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM18_RS09555	COG0047	phosphoribosylformylglycinamidine synthase activity
GM18_RS09555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM18_RS09560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GM18_RS09565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GM18_RS09580	COG3485	protocatechuate 3,4-dioxygenase
GM18_RS09615	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GM18_RS09620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM18_RS09635	COG1100	Small GTP-binding protein
GM18_RS09640	COG1285	pathogenesis
GM18_RS09645	COG1592	Rubrerythrin
GM18_RS09655	COG0613	PHP domain protein
GM18_RS09665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GM18_RS09670	COG2084	Dehydrogenase
GM18_RS09700	COG0419	ATPase involved in DNA repair
GM18_RS09710	COG1994	Peptidase M50
GM18_RS09715	COG0180	Tryptophanyl-tRNA synthetase
GM18_RS09720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GM18_RS09725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GM18_RS09730	COG1355	regulation of microtubule-based process
GM18_RS09735	COG0617	tRNA 3'-terminal CCA addition
GM18_RS09735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GM18_RS09735	COG3620	sequence-specific DNA binding
GM18_RS09755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GM18_RS09760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GM18_RS09765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GM18_RS09775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS09785	COG0018	arginyl-trna synthetase
GM18_RS09795	COG0745	RESPONSE REGULATOR receiver
GM18_RS09800	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GM18_RS09805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM18_RS09815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GM18_RS09820	COG0280	phosphate acetyltransferase
GM18_RS09825	COG0521	Mo-molybdopterin cofactor biosynthetic process
GM18_RS09835	COG0303	'Molybdopterin
GM18_RS09845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS09855	COG4191	Histidine kinase
GM18_RS09860	COG2204	response regulator
GM18_RS09875	COG3064	Membrane
GM18_RS09875	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS09880	COG5557	Pfam Polysulphide reductase, NrfD
GM18_RS09885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GM18_RS09890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM18_RS09900	COG4221	oxidoreductase activity
GM18_RS09910	COG3189	MarR family transcriptional regulator
GM18_RS09915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GM18_RS09920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GM18_RS09925	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM18_RS09925	COG0022	dehydrogenase e1 component
GM18_RS09935	COG0784	Response regulator, receiver
GM18_RS09935	COG2205	protein histidine kinase activity
GM18_RS09935	COG5002	protein histidine kinase activity
GM18_RS09965	COG2201	protein-glutamate methylesterase activity
GM18_RS09980	COG4191	Histidine kinase
GM18_RS09985	COG2204	response regulator
GM18_RS10000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GM18_RS10005	COG4651	solute:proton antiporter activity
GM18_RS10005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GM18_RS10010	COG0058	SHG alpha-glucan phosphorylase activity
GM18_RS10020	COG1942	4-Oxalocrotonate Tautomerase
GM18_RS10040	COG2062	phosphohistidine phosphatase, SixA
GM18_RS10080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GM18_RS10085	COG1122	ATPase activity
GM18_RS10090	COG1278	Cold shock
GM18_RS10095	COG1671	Belongs to the UPF0178 family
GM18_RS10105	COG0626	cystathionine gamma-synthase activity
GM18_RS10110	COG0626	cystathionine gamma-synthase activity
GM18_RS10120	COG3344	reverse transcriptase
GM18_RS10125	COG1022	Amp-dependent synthetase and ligase
GM18_RS10130	COG2271	Major facilitator Superfamily
GM18_RS10145	COG0628	permease
GM18_RS10160	COG0577	efflux transmembrane transporter activity
GM18_RS10180	COG0582	viral genome integration into host DNA
GM18_RS10210	COG3344	reverse transcriptase
GM18_RS10240	COG1585	Membrane protein implicated in regulation of membrane protease activity
GM18_RS10245	COG2268	Band 7 protein
GM18_RS10250	COG1280	lysine exporter protein (LysE YggA)
GM18_RS10255	COG2985	domain, Protein
GM18_RS10255	COG0569	domain protein
GM18_RS10265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GM18_RS10275	COG1566	PFAM secretion protein HlyD family protein
GM18_RS10280	COG0577	efflux transmembrane transporter activity
GM18_RS10280	COG1136	(ABC) transporter
GM18_RS10285	COG0577	efflux transmembrane transporter activity
GM18_RS10285	COG1136	(ABC) transporter
GM18_RS10300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GM18_RS10315	COG1950	PFAM Membrane protein of
GM18_RS10330	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GM18_RS10370	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GM18_RS10385	COG3576	pyridoxamine 5-phosphate
GM18_RS10405	COG1937	Protein conserved in bacteria
GM18_RS10410	COG2217	Heavy metal translocating P-type atpase
GM18_RS10420	COG0577	efflux transmembrane transporter activity
GM18_RS10420	COG1136	(ABC) transporter
GM18_RS10425	COG1136	(ABC) transporter
GM18_RS10425	COG0577	efflux transmembrane transporter activity
GM18_RS10435	COG2217	Heavy metal translocating P-type atpase
GM18_RS10440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS10460	COG4191	Histidine kinase
GM18_RS10465	COG2204	response regulator
GM18_RS10490	COG1960	acyl-CoA dehydrogenase activity
GM18_RS10495	COG0183	Belongs to the thiolase family
GM18_RS10505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GM18_RS10535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS10550	COG4191	Histidine kinase
GM18_RS10550	COG0784	Response regulator, receiver
GM18_RS10560	COG0670	Belongs to the BI1 family
GM18_RS10580	COG4251	negative regulation of phosphorylation
GM18_RS10590	COG2186	Transcriptional regulator
GM18_RS10600	COG1960	acyl-CoA dehydrogenase activity
GM18_RS10605	COG0183	Belongs to the thiolase family
GM18_RS10610	COG1250	3-hydroxyacyl-CoA dehydrogenase
GM18_RS10610	COG1024	Enoyl-CoA hydratase
GM18_RS10635	COG2204	response regulator
GM18_RS10675	COG0577	efflux transmembrane transporter activity
GM18_RS10675	COG1136	(ABC) transporter
GM18_RS10690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GM18_RS10690	COG2070	2-Nitropropane dioxygenase
GM18_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
GM18_RS10695	COG3321	synthase
GM18_RS10695	COG0604	alcohol dehydrogenase
GM18_RS10705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM18_RS10710	COG0596	Alpha beta hydrolase
GM18_RS10715	COG0318	PFAM AMP-dependent synthetase and ligase
GM18_RS10720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS10725	COG2091	lysine biosynthetic process via aminoadipic acid
GM18_RS10785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GM18_RS10785	COG0248	Ppx GppA phosphatase
GM18_RS10795	COG0776	regulation of translation
GM18_RS10805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GM18_RS10820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GM18_RS10825	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GM18_RS10830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GM18_RS10840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GM18_RS10845	COG0084	hydrolase, TatD family'
GM18_RS10850	COG4251	negative regulation of phosphorylation
GM18_RS10865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GM18_RS10885	COG1305	Transglutaminase-like
GM18_RS10890	COG0583	DNA-binding transcription factor activity
GM18_RS10925	COG0835	chemotaxis
GM18_RS10935	COG0835	chemotaxis
GM18_RS10945	COG0784	Response regulator, receiver
GM18_RS10945	COG0643	Histidine kinase
GM18_RS10945	COG2198	Histidine kinase
GM18_RS10950	COG2201	protein-glutamate methylesterase activity
GM18_RS10955	COG0745	RESPONSE REGULATOR receiver
GM18_RS10960	COG4251	negative regulation of phosphorylation
GM18_RS10970	COG0579	oxidoreductase
GM18_RS10980	COG2176	DNA-directed DNA polymerase activity
GM18_RS11045	COG0545	Peptidyl-prolyl cis-trans isomerase
GM18_RS11055	COG0837	glucose binding
GM18_RS11065	COG3008	intermembrane lipid transfer
GM18_RS11070	COG2995	paraquat-inducible protein a
GM18_RS11090	COG2204	response regulator
GM18_RS11100	COG2201	protein-glutamate methylesterase activity
GM18_RS11120	COG0835	chemotaxis
GM18_RS11140	COG0776	regulation of translation
GM18_RS11145	COG0072	phenylalanine-tRNA ligase activity
GM18_RS11150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GM18_RS11155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GM18_RS11160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GM18_RS11165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GM18_RS11170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GM18_RS11190	COG4191	Histidine kinase
GM18_RS11200	COG1525	nuclease
GM18_RS11205	COG5557	Pfam Polysulphide reductase, NrfD
GM18_RS11210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GM18_RS11225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM18_RS11245	COG0482	sulfurtransferase activity
GM18_RS11250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GM18_RS11255	COG4149	molybdate abc transporter
GM18_RS11260	COG0840	transmembrane signaling receptor activity
GM18_RS11275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM18_RS11295	COG0438	transferase activity, transferring glycosyl groups
GM18_RS11320	COG0489	protein tyrosine kinase activity
GM18_RS11320	COG3206	protein involved in exopolysaccharide biosynthesis
GM18_RS11335	COG4464	protein tyrosine phosphatase activity
GM18_RS11370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GM18_RS11375	COG1335	isochorismatase
GM18_RS11380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GM18_RS11385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GM18_RS11390	COG0135	phosphoribosylanthranilate isomerase activity
GM18_RS11395	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GM18_RS11400	COG0134	indole-3-glycerol-phosphate synthase activity
GM18_RS11405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GM18_RS11410	COG0512	Glutamine amidotransferase of anthranilate synthase
GM18_RS11415	COG0745	RESPONSE REGULATOR receiver
GM18_RS11420	COG4251	negative regulation of phosphorylation
GM18_RS11435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GM18_RS11450	COG4191	Histidine kinase
GM18_RS11455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS11465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GM18_RS11470	COG1704	LemA family
GM18_RS11480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GM18_RS11495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM18_RS11505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GM18_RS11510	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GM18_RS11510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GM18_RS11520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GM18_RS11525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GM18_RS11530	COG1862	Preprotein translocase
GM18_RS11535	COG0343	queuine tRNA-ribosyltransferase activity
GM18_RS11540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GM18_RS11545	COG2385	sporulation resulting in formation of a cellular spore
GM18_RS11550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GM18_RS11555	COG0444	Belongs to the ABC transporter superfamily
GM18_RS11560	COG4608	Belongs to the ABC transporter superfamily
GM18_RS11570	COG0312	modulator of DNA gyrase
GM18_RS11575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GM18_RS11580	COG0497	DNA recombination
GM18_RS11585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GM18_RS11590	COG0058	SHG alpha-glucan phosphorylase activity
GM18_RS11595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GM18_RS11600	COG0205	6-phosphofructokinase activity
GM18_RS11650	COG0772	Belongs to the SEDS family
GM18_RS11655	COG0768	penicillin binding
GM18_RS11675	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GM18_RS11685	COG1489	DNA binding
GM18_RS11695	COG2172	sigma factor antagonist activity
GM18_RS11700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GM18_RS11715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM18_RS11720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GM18_RS11750	COG1704	LemA family
GM18_RS11755	COG0501	Belongs to the peptidase M48B family
GM18_RS11765	COG2814	Major facilitator Superfamily
GM18_RS11775	COG0697	spore germination
GM18_RS11780	COG1959	2 iron, 2 sulfur cluster binding
GM18_RS11785	COG0471	metal ion transport
GM18_RS11840	COG5002	protein histidine kinase activity
GM18_RS11840	COG2198	Histidine kinase
GM18_RS11840	COG0784	Response regulator, receiver
GM18_RS11880	COG0730	response to heat
GM18_RS11890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GM18_RS11895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GM18_RS11905	COG1077	Cell shape determining protein MreB Mrl
GM18_RS11910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS11915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GM18_RS11925	COG0492	ferredoxin-NADP+ reductase activity
GM18_RS11935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GM18_RS11950	COG1528	Iron-storage protein
GM18_RS11955	COG0463	Glycosyl transferase, family 2
GM18_RS11965	COG0330	HflC and HflK could
GM18_RS11970	COG2204	response regulator
GM18_RS12000	COG0667	Aldo Keto reductase
GM18_RS12025	COG3344	reverse transcriptase
GM18_RS12035	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS12090	COG0745	RESPONSE REGULATOR receiver
GM18_RS12095	COG2205	protein histidine kinase activity
GM18_RS12110	COG0745	RESPONSE REGULATOR receiver
GM18_RS12115	COG2204	response regulator
GM18_RS12155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GM18_RS12165	COG0463	Glycosyl transferase, family 2
GM18_RS12230	COG0489	protein tyrosine kinase activity
GM18_RS12240	COG4964	Belongs to the GSP D family
GM18_RS12285	COG1269	ATP hydrolysis coupled proton transport
GM18_RS12310	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GM18_RS12320	COG1394	ATPase activity, coupled to movement of substances
GM18_RS12335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GM18_RS12340	COG1140	nitrate reductase beta subunit
GM18_RS12350	COG2181	nitrate reductase activity
GM18_RS12355	COG2223	nitrite transmembrane transporter activity
GM18_RS12360	COG1968	undecaprenyl-diphosphatase activity
GM18_RS12410	COG0463	Glycosyl transferase, family 2
GM18_RS12430	COG1216	Glycosyl transferase, family 2
GM18_RS12430	COG0463	Glycosyl transferase, family 2
GM18_RS12440	COG0438	transferase activity, transferring glycosyl groups
GM18_RS12465	COG0463	Glycosyl transferase, family 2
GM18_RS12465	COG1216	Glycosyl transferase, family 2
GM18_RS12490	COG1131	(ABC) transporter
GM18_RS12510	COG4968	Prepilin-type N-terminal cleavage methylation domain
GM18_RS12515	COG2204	response regulator
GM18_RS12520	COG3852	Histidine kinase
GM18_RS12525	COG1459	type II secretion system
GM18_RS12535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS12540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GM18_RS12555	COG0196	riboflavin kinase activity
GM18_RS12560	COG0805	protein transport
GM18_RS12565	COG0557	exoribonuclease II activity
GM18_RS12570	COG0741	lytic transglycosylase activity
GM18_RS12580	COG1162	GTPase activity
GM18_RS12585	COG1846	Transcriptional regulator
GM18_RS12595	COG1566	PFAM secretion protein HlyD family protein
GM18_RS12600	COG2814	Major facilitator Superfamily
GM18_RS12610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS12615	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GM18_RS12620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM18_RS12635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GM18_RS12640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GM18_RS12645	COG0037	tRNA processing
GM18_RS12655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GM18_RS12660	COG0601	transmembrane transport
GM18_RS12665	COG0747	negative chemotaxis
GM18_RS12700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GM18_RS12710	COG0537	adenosine 5'-monophosphoramidase activity
GM18_RS12715	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GM18_RS12725	COG3852	Histidine kinase
GM18_RS12730	COG2204	response regulator
GM18_RS12750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GM18_RS12755	COG3108	Peptidase M15
GM18_RS12780	COG3706	GGDEF domain
GM18_RS12785	COG3657	addiction module killer protein
GM18_RS12805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GM18_RS12815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GM18_RS12820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GM18_RS12840	COG1703	isobutyryl-CoA mutase activity
GM18_RS12845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS12845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS12850	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GM18_RS12885	COG2703	oxygen carrier activity
GM18_RS12890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GM18_RS12900	COG0488	(ABC) transporter
GM18_RS12915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GM18_RS12920	COG0424	maF-like protein
GM18_RS12930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GM18_RS12935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GM18_RS12940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GM18_RS12940	COG0758	DNA mediated transformation
GM18_RS12950	COG0826	peptidase U32
GM18_RS12960	COG5002	protein histidine kinase activity
GM18_RS12985	COG0312	modulator of DNA gyrase
GM18_RS12995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GM18_RS13005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GM18_RS13025	COG0612	Peptidase, M16
GM18_RS13045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GM18_RS13055	COG0066	3-isopropylmalate dehydratase activity
GM18_RS13060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GM18_RS13065	COG1611	Belongs to the LOG family
GM18_RS13070	COG1278	Cold shock
GM18_RS13085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM18_RS13090	COG1183	phosphatidylcholine synthase activity
GM18_RS13095	COG0688	phosphatidylethanolamine metabolic process
GM18_RS13100	COG0440	acetolactate synthase activity
GM18_RS13105	COG0028	Belongs to the TPP enzyme family
GM18_RS13110	COG0129	dihydroxy-acid dehydratase activity
GM18_RS13115	COG1214	PFAM Peptidase M22, glycoprotease
GM18_RS13120	COG0750	zinc metalloprotease
GM18_RS13125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GM18_RS13130	COG4589	Belongs to the CDS family
GM18_RS13135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GM18_RS13140	COG0233	cytoplasmic translational termination
GM18_RS13145	COG0528	UMP kinase activity
GM18_RS13150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GM18_RS13155	COG0052	Belongs to the universal ribosomal protein uS2 family
GM18_RS13165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GM18_RS13185	COG0359	binds to the 23S rRNA
GM18_RS13195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GM18_RS13200	COG0360	Binds together with S18 to 16S ribosomal RNA
GM18_RS13205	COG0012	GTP binding
GM18_RS13210	COG0193	aminoacyl-tRNA hydrolase activity
GM18_RS13215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GM18_RS13220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GM18_RS13255	COG2205	protein histidine kinase activity
GM18_RS13265	COG4771	TonB-dependent receptor
GM18_RS13270	COG2205	protein histidine kinase activity
GM18_RS13300	COG0745	RESPONSE REGULATOR receiver
GM18_RS13305	COG5002	protein histidine kinase activity
GM18_RS13320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GM18_RS13325	COG0585	pseudouridine synthase activity
GM18_RS13335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GM18_RS13340	COG0840	transmembrane signaling receptor activity
GM18_RS13370	COG1027	Aspartate ammonia-lyase
GM18_RS13375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GM18_RS13380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GM18_RS13385	COG1193	negative regulation of DNA recombination
GM18_RS13400	COG0305	Participates in initiation and elongation during chromosome replication
GM18_RS13410	COG0745	RESPONSE REGULATOR receiver
GM18_RS13425	COG3852	Histidine kinase
GM18_RS13435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GM18_RS13440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GM18_RS13465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GM18_RS13480	COG0494	nUDIX hydrolase
GM18_RS13485	COG0840	transmembrane signaling receptor activity
GM18_RS13485	COG0840	transmembrane signaling receptor activity
GM18_RS13490	COG0430	RNA-3'-phosphate cyclase activity
GM18_RS13515	COG1960	acyl-CoA dehydrogenase activity
GM18_RS13520	COG1250	3-hydroxyacyl-CoA dehydrogenase
GM18_RS13525	COG0183	Belongs to the thiolase family
GM18_RS13530	COG4251	negative regulation of phosphorylation
GM18_RS13545	COG0840	transmembrane signaling receptor activity
GM18_RS13545	COG0840	transmembrane signaling receptor activity
GM18_RS13635	COG1278	Cold shock
GM18_RS13680	COG0069	glutamate synthase activity
GM18_RS13680	COG0067	glutamate synthase
GM18_RS13680	COG0070	glutamate synthase
GM18_RS13685	COG0493	'glutamate synthase
GM18_RS13715	COG1183	phosphatidylcholine synthase activity
GM18_RS13720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GM18_RS13730	COG2823	Periplasmic or secreted lipoprotein
GM18_RS13740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GM18_RS13755	COG1032	radical SAM domain protein
GM18_RS13810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS13830	COG3383	formate dehydrogenase (NAD+) activity
GM18_RS13835	COG0746	molybdenum cofactor guanylyltransferase activity
GM18_RS13850	COG4974	Belongs to the 'phage' integrase family
GM18_RS13870	COG1484	DNA-dependent DNA replication
GM18_RS13875	COG4584	PFAM Integrase catalytic
GM18_RS13905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GM18_RS13910	COG0284	orotidine-5'-phosphate decarboxylase activity
GM18_RS13915	COG0442	prolyl-tRNA aminoacylation
GM18_RS13920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GM18_RS13935	COG1881	PFAM PEBP family protein
GM18_RS13940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GM18_RS13945	COG0617	tRNA 3'-terminal CCA addition
GM18_RS13950	COG3437	response regulator, receiver
GM18_RS13950	COG2770	Histidine kinase
GM18_RS13965	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM18_RS13970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM18_RS13970	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM18_RS13980	COG0039	L-malate dehydrogenase activity
GM18_RS14000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GM18_RS14015	COG0277	FAD linked oxidase domain protein
GM18_RS14020	COG1346	cytolysis
GM18_RS14045	COG1139	Iron-sulfur cluster binding protein
GM18_RS14055	COG2353	YceI-like domain
GM18_RS14065	COG1166	arginine decarboxylase activity
GM18_RS14085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GM18_RS14090	COG2204	response regulator
GM18_RS14095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM18_RS14095	COG4191	Histidine kinase
GM18_RS14105	COG1331	Highly conserved protein containing a thioredoxin domain
GM18_RS14110	COG0537	adenosine 5'-monophosphoramidase activity
GM18_RS14125	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GM18_RS14135	COG5002	protein histidine kinase activity
GM18_RS14150	COG2824	Alkylphosphonate utilization operon protein PhnA
GM18_RS14155	COG3344	reverse transcriptase
GM18_RS14165	COG2201	protein-glutamate methylesterase activity
GM18_RS14195	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GM18_RS14215	COG0745	RESPONSE REGULATOR receiver
GM18_RS14235	COG0569	domain protein
GM18_RS14240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GM18_RS14340	COG3852	Histidine kinase
GM18_RS14350	COG0765	amino acid transport
GM18_RS14355	COG1126	abc transporter atp-binding protein
GM18_RS14390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GM18_RS14405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GM18_RS14455	COG3344	reverse transcriptase
GM18_RS14470	COG0582	viral genome integration into host DNA
GM18_RS14475	COG4974	Belongs to the 'phage' integrase family
GM18_RS14485	COG2003	Belongs to the UPF0758 family
GM18_RS14600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GM18_RS14635	COG4804	nuclease activity
GM18_RS14890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GM18_RS14920	COG0358	DNA primase activity
GM18_RS14925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GM18_RS14975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GM18_RS14990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GM18_RS15005	COG0402	S-adenosylhomocysteine deaminase activity
GM18_RS15010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GM18_RS15015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GM18_RS15020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GM18_RS15030	COG0205	6-phosphofructokinase activity
GM18_RS15060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GM18_RS15065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GM18_RS15070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GM18_RS15070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GM18_RS15085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GM18_RS15090	COG2131	deaminase
GM18_RS15110	COG1053	succinate dehydrogenase
GM18_RS15110	COG3976	FMN-binding domain protein
GM18_RS15110	COG0431	NADPH-dependent FMN reductase
GM18_RS15115	COG1053	succinate dehydrogenase
GM18_RS15125	COG2183	response to ionizing radiation
GM18_RS15210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM18_RS15215	COG1763	Mo-molybdopterin cofactor biosynthetic process
GM18_RS15245	COG1607	acyl-coa hydrolase
GM18_RS15255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM18_RS15260	COG3123	guanosine phosphorylase activity
GM18_RS15270	COG0174	glutamine synthetase
GM18_RS15285	COG0739	heme binding
GM18_RS15300	COG1643	Atp-dependent helicase
GM18_RS15310	COG0671	phosphoesterase, PA-phosphatase related
GM18_RS15345	COG1187	pseudouridine synthase activity
GM18_RS15350	COG2733	membrane
GM18_RS15360	COG0825	malonyl-CoA metabolic process
GM18_RS15365	COG0587	DNA-directed DNA polymerase activity
GM18_RS15370	COG0124	histidyl-tRNA synthetase
GM18_RS15375	COG3706	GGDEF domain
GM18_RS15400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GM18_RS15405	COG0698	ribose 5-phosphate isomerase
GM18_RS15410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM18_RS15415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM18_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
GM18_RS15425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GM18_RS15430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM18_RS15435	COG0416	fatty acid biosynthetic process
GM18_RS15440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GM18_RS15450	COG0616	signal peptide processing
GM18_RS15465	COG2201	protein-glutamate methylesterase activity
GM18_RS15485	COG1127	ABC transporter
GM18_RS15495	COG1832	CoA-binding protein
GM18_RS15510	COG0123	including yeast histone deacetylase and acetoin utilization protein
GM18_RS15515	COG0004	ammonium transporteR
GM18_RS15520	COG1215	transferase activity, transferring glycosyl groups
GM18_RS15525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GM18_RS15535	COG0309	Hydrogenase expression formation protein (HypE)
GM18_RS15545	COG0298	carbon dioxide binding
GM18_RS15550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GM18_RS15560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM18_RS15565	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GM18_RS15570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GM18_RS15575	COG5557	Pfam Polysulphide reductase, NrfD
GM18_RS15580	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS15585	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GM18_RS15590	COG0375	protein maturation
GM18_RS15645	COG3426	butyrate kinase activity
GM18_RS15655	COG0835	chemotaxis
GM18_RS15815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GM18_RS15830	COG4948	Mandelate Racemase Muconate Lactonizing
GM18_RS15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM18_RS15885	COG3344	reverse transcriptase
GM18_RS15905	COG0729	surface antigen
GM18_RS15915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GM18_RS15935	COG3876	Protein conserved in bacteria
GM18_RS15945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GM18_RS15955	COG1278	Cold shock
GM18_RS15965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS15970	COG3261	NADH dehydrogenase
GM18_RS15970	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GM18_RS15975	COG0651	ATP synthesis coupled electron transport
GM18_RS15990	COG0651	ATP synthesis coupled electron transport
GM18_RS16010	COG0651	ATP synthesis coupled electron transport
GM18_RS16030	COG3005	denitrification pathway
GM18_RS16035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GM18_RS16045	COG0571	ribonuclease III activity
GM18_RS16050	COG1414	Transcriptional regulator
GM18_RS16055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM18_RS16085	COG2086	electron transfer activity
GM18_RS16095	COG0644	oxidoreductase
GM18_RS16100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM18_RS16105	COG1902	pentaerythritol trinitrate reductase activity
GM18_RS16105	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM18_RS16110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS16125	COG3852	Histidine kinase
GM18_RS16135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM18_RS16155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS16160	COG2204	response regulator
GM18_RS16165	COG3852	Histidine kinase
GM18_RS16170	COG1454	alcohol dehydrogenase
GM18_RS16205	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GM18_RS16235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM18_RS16240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GM18_RS16245	COG0470	DNA polymerase III
GM18_RS16250	COG1774	PSP1 C-terminal conserved region
GM18_RS16255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GM18_RS16255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GM18_RS16265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GM18_RS16280	COG1758	RNA polymerase activity
GM18_RS16285	COG0194	GDP metabolic process
GM18_RS16290	COG1561	YicC-like family, N-terminal region
GM18_RS16305	COG0519	Catalyzes the synthesis of GMP from XMP
GM18_RS16320	COG4191	Histidine kinase
GM18_RS16330	COG2204	response regulator
GM18_RS16355	COG2234	aminopeptidase activity
GM18_RS16365	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM18_RS16365	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM18_RS16365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GM18_RS16365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM18_RS16375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GM18_RS16380	COG0045	succinate-CoA ligase (ADP-forming) activity
GM18_RS16385	COG0281	malic enzyme
GM18_RS16385	COG0280	phosphate acetyltransferase
GM18_RS16390	COG1301	dicarboxylic acid transport
GM18_RS16400	COG4191	Histidine kinase
GM18_RS16400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM18_RS16405	COG2181	nitrate reductase activity
GM18_RS16405	COG0247	lactate metabolic process
GM18_RS16425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM18_RS16450	COG0776	regulation of translation
GM18_RS16455	COG0539	negative regulation of cytoplasmic translation
GM18_RS16460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GM18_RS16465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GM18_RS16470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GM18_RS16475	COG0287	Prephenate dehydrogenase
GM18_RS16480	COG1605	Chorismate mutase
GM18_RS16480	COG0077	Prephenate dehydratase
GM18_RS16490	COG0577	efflux transmembrane transporter activity
GM18_RS16495	COG0577	efflux transmembrane transporter activity
GM18_RS16500	COG0577	efflux transmembrane transporter activity
GM18_RS16500	COG1136	(ABC) transporter
GM18_RS16505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM18_RS16510	COG1550	Protein conserved in bacteria
GM18_RS16520	COG0482	sulfurtransferase activity
GM18_RS16535	COG2205	protein histidine kinase activity
GM18_RS16535	COG0784	Response regulator, receiver
GM18_RS16535	COG5002	protein histidine kinase activity
GM18_RS16540	COG2205	protein histidine kinase activity
GM18_RS16540	COG0784	Response regulator, receiver
GM18_RS16540	COG5002	protein histidine kinase activity
GM18_RS16815	COG1253	flavin adenine dinucleotide binding
GM18_RS16825	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GM18_RS16835	COG2204	response regulator
GM18_RS16840	COG0436	Aminotransferase
GM18_RS16845	COG3012	SEC-C Motif Domain Protein
GM18_RS16860	COG2033	superoxide reductase activity
GM18_RS16865	COG1418	mRNA catabolic process
GM18_RS16880	COG0513	Belongs to the DEAD box helicase family
GM18_RS16890	COG2205	protein histidine kinase activity
GM18_RS16895	COG0745	RESPONSE REGULATOR receiver
GM18_RS16900	COG0840	transmembrane signaling receptor activity
GM18_RS16910	COG0517	IMP dehydrogenase activity
GM18_RS16920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GM18_RS16925	COG0488	(ABC) transporter
GM18_RS16930	COG2095	MarC family integral membrane protein
GM18_RS16945	COG0217	transcriptional regulatory protein
GM18_RS16950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GM18_RS16955	COG0632	four-way junction helicase activity
GM18_RS16960	COG2255	four-way junction helicase activity
GM18_RS16990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GM18_RS17045	COG1053	succinate dehydrogenase
GM18_RS17055	COG0343	queuine tRNA-ribosyltransferase activity
GM18_RS17065	COG3956	TIGRFAM MazG family protein
GM18_RS17100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GM18_RS17100	COG0662	Cupin 2, conserved barrel domain protein
GM18_RS17115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GM18_RS17120	COG0285	dihydrofolate synthase activity
GM18_RS17130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GM18_RS17135	COG0159	tryptophan synthase activity
GM18_RS17160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GM18_RS17175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GM18_RS17185	COG1657	PFAM Prenyltransferase squalene oxidase
GM18_RS17190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM18_RS17195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GM18_RS17255	COG0791	NLP P60 protein
GM18_RS17255	COG1388	LysM domain
GM18_RS17275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GM18_RS17280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GM18_RS17350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GM18_RS17355	COG1254	Belongs to the acylphosphatase family
GM18_RS17370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GM18_RS17380	COG2195	Cleaves the N-terminal amino acid of tripeptides
GM18_RS17385	COG4783	chaperone-mediated protein folding
GM18_RS17430	COG1640	4-alpha-glucanotransferase
GM18_RS17435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GM18_RS17455	COG0191	fructose-bisphosphate aldolase activity
GM18_RS17475	COG0791	NLP P60 protein
GM18_RS17485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GM18_RS17495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GM18_RS17500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GM18_RS17505	COG1480	7TM receptor with intracellular HD hydrolase
GM18_RS17510	COG0148	phosphopyruvate hydratase activity
GM18_RS17515	COG0564	pseudouridine synthase activity
GM18_RS17535	COG3530	Putative quorum-sensing-regulated virulence factor
GM18_RS17570	COG1126	abc transporter atp-binding protein
GM18_RS17575	COG0765	amino acid transport
GM18_RS17585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GM18_RS17595	COG1923	regulation of RNA biosynthetic process
GM18_RS17600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GM18_RS17610	COG1686	Belongs to the peptidase S11 family
GM18_RS17620	COG2208	phosphoserine phosphatase activity
GM18_RS17625	COG0784	Response regulator, receiver
GM18_RS17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GM18_RS17725	COG1122	ATPase activity
GM18_RS17770	COG3706	GGDEF domain
GM18_RS17775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GM18_RS17780	COG1360	Flagellar Motor Protein
GM18_RS17790	COG1584	GPR1 FUN34 yaaH family protein
GM18_RS17795	COG0443	Heat shock 70 kDa protein
GM18_RS17845	COG1598	PFAM Uncharacterised protein family UPF0150
GM18_RS17850	COG1032	radical SAM domain protein
GM18_RS17865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM18_RS17870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS17875	COG3550	peptidyl-serine autophosphorylation
GM18_RS17885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS17955	COG0519	Catalyzes the synthesis of GMP from XMP
GM18_RS17955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GM18_RS17960	COG0517	IMP dehydrogenase activity
GM18_RS17960	COG0516	GMP reductase activity
GM18_RS17975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM18_RS18005	COG0268	Binds directly to 16S ribosomal RNA
GM18_RS18020	COG0495	leucyl-tRNA aminoacylation
GM18_RS18030	COG0745	RESPONSE REGULATOR receiver
GM18_RS18040	COG2201	protein-glutamate methylesterase activity
GM18_RS18045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GM18_RS18055	COG0745	RESPONSE REGULATOR receiver
GM18_RS18060	COG0835	chemotaxis
GM18_RS18065	COG0745	RESPONSE REGULATOR receiver
GM18_RS18070	COG0835	chemotaxis
GM18_RS18075	COG3267	Type II secretory pathway component ExeA
GM18_RS18075	COG3409	Peptidoglycan-binding domain 1 protein
GM18_RS18080	COG2198	Histidine kinase
GM18_RS18080	COG0643	Histidine kinase
GM18_RS18085	COG0745	RESPONSE REGULATOR receiver
GM18_RS18095	COG1160	GTP binding
GM18_RS18120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GM18_RS18125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GM18_RS18155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GM18_RS18160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GM18_RS18175	COG4120	Belongs to the binding-protein-dependent transport system permease family
GM18_RS18200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GM18_RS18215	COG0243	molybdopterin cofactor binding
GM18_RS18220	COG0784	Response regulator, receiver
GM18_RS18220	COG0835	chemotaxis
GM18_RS18225	COG0463	Glycosyl transferase, family 2
GM18_RS18235	COG1597	lipid kinase activity
GM18_RS18240	COG3344	reverse transcriptase
GM18_RS18245	COG1067	ATP-dependent peptidase activity
GM18_RS18250	COG0321	lipoyl(octanoyl) transferase activity
GM18_RS18255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM18_RS18260	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM18_RS18265	COG0567	Dehydrogenase, E1 component
GM18_RS18270	COG1993	acr, cog1993
GM18_RS18275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GM18_RS18285	COG1530	ribonuclease E activity
GM18_RS18325	COG0697	spore germination
GM18_RS18340	COG1403	HNH endonuclease
GM18_RS18345	COG0488	(ABC) transporter
GM18_RS18350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM18_RS18355	COG0612	Peptidase, M16
GM18_RS18370	COG1024	Enoyl-CoA hydratase
GM18_RS18380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GM18_RS18400	COG2985	domain, Protein
GM18_RS18400	COG0569	domain protein
GM18_RS18440	COG2204	response regulator
GM18_RS18450	COG2204	response regulator
GM18_RS18475	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS18475	COG3064	Membrane
GM18_RS18480	COG5557	Pfam Polysulphide reductase, NrfD
GM18_RS18515	COG0237	dephospho-CoA kinase activity
GM18_RS18520	COG1414	Transcriptional regulator
GM18_RS18525	COG3852	Histidine kinase
GM18_RS18535	COG2022	thiamine diphosphate biosynthetic process
GM18_RS18540	COG0352	thiamine-phosphate diphosphorylase activity
GM18_RS18545	COG1242	4 iron, 4 sulfur cluster binding
GM18_RS18550	COG0179	Fumarylacetoacetate (FAA) hydrolase
GM18_RS18570	COG1278	Cold shock
GM18_RS18575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GM18_RS18575	COG0574	Belongs to the PEP-utilizing enzyme family
GM18_RS18580	COG0751	glycine-tRNA ligase activity
GM18_RS18585	COG0752	glycyl-tRNA synthetase alpha subunit
GM18_RS18595	COG3437	response regulator, receiver
GM18_RS18615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GM18_RS18620	COG0242	peptide deformylase activity
GM18_RS18650	COG0436	Aminotransferase
GM18_RS18655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GM18_RS18660	COG3290	protein histidine kinase activity
GM18_RS18660	COG0840	transmembrane signaling receptor activity
GM18_RS18670	COG2201	protein-glutamate methylesterase activity
GM18_RS18675	COG0784	Response regulator, receiver
GM18_RS18675	COG0643	Histidine kinase
GM18_RS18675	COG2198	Histidine kinase
GM18_RS18690	COG1666	GTP binding
GM18_RS18695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM18_RS18705	COG0348	domain, Protein
GM18_RS18710	COG0037	tRNA processing
GM18_RS18715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GM18_RS18720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GM18_RS18720	COG0646	methionine synthase
GM18_RS18725	COG1227	inorganic diphosphatase activity
GM18_RS18725	COG0517	IMP dehydrogenase activity
GM18_RS18730	COG0586	Pfam SNARE associated Golgi protein
GM18_RS18735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GM18_RS18755	COG0432	Pfam Uncharacterised protein family UPF0047
GM18_RS18765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM18_RS18785	COG4191	Histidine kinase
GM18_RS18785	COG2205	protein histidine kinase activity
GM18_RS18785	COG0745	RESPONSE REGULATOR receiver
GM18_RS18790	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GM18_RS18835	COG2165	general secretion pathway protein
GM18_RS18890	COG1295	ribonuclease BN
GM18_RS18925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GM18_RS18930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM18_RS18935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM18_RS18940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GM18_RS18945	COG0542	response to heat
GM18_RS18955	COG0501	Belongs to the peptidase M48B family
GM18_RS18960	COG0297	glycogen (starch) synthase activity
GM18_RS18965	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GM18_RS18970	COG3875	lactate racemase activity
GM18_RS18975	COG0277	FAD linked oxidase domain protein
GM18_RS18985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GM18_RS18990	COG0439	Biotin carboxylase
GM18_RS18995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS18995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM18_RS19000	COG0346	lactoylglutathione lyase activity
GM18_RS19025	COG0124	histidyl-tRNA synthetase
GM18_RS19030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GM18_RS19055	COG2814	Major facilitator Superfamily
GM18_RS19060	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GM18_RS19070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM18_RS19075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM18_RS19090	COG1960	acyl-CoA dehydrogenase activity
GM18_RS19095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GM18_RS19100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GM18_RS19105	COG2252	PERMEase
GM18_RS19135	COG1053	succinate dehydrogenase
GM18_RS19195	COG1121	(ABC) transporter
GM18_RS19200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GM18_RS19210	COG3344	reverse transcriptase
GM18_RS19230	COG2226	methyltransferase
GM18_RS19250	COG0646	methionine synthase
GM18_RS19250	COG1410	methionine synthase
GM18_RS19270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GM18_RS19300	COG1598	PFAM Uncharacterised protein family UPF0150
GM18_RS19305	COG0366	Alpha amylase catalytic
GM18_RS19325	COG3344	reverse transcriptase
GM18_RS19380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GM18_RS19400	COG0587	DNA-directed DNA polymerase activity
GM18_RS19410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GM18_RS19420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GM18_RS19425	COG1181	Belongs to the D-alanine--D-alanine ligase family
GM18_RS19430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GM18_RS19435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GM18_RS19440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GM18_RS19445	COG0772	Belongs to the SEDS family
GM18_RS19450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GM18_RS19455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM18_RS19460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GM18_RS19465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GM18_RS19475	COG3116	cell division
GM18_RS19480	COG0275	rRNA processing
GM18_RS19485	COG2001	Belongs to the MraZ family
GM18_RS19505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GM18_RS19515	COG0116	Belongs to the methyltransferase superfamily
GM18_RS19515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GM18_RS19530	COG1217	gtp-binding protein TYPA
GM18_RS19545	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM18_RS19550	COG4974	Belongs to the 'phage' integrase family
GM18_RS19560	COG0427	acetyl-CoA hydrolase
GM18_RS19570	COG4191	Histidine kinase
GM18_RS19575	COG2193	ferroxidase activity
GM18_RS19580	COG2233	PERMEase
GM18_RS19585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GM18_RS19595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GM18_RS19620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM18_RS19640	COG4585	Histidine kinase
GM18_RS19645	COG0501	Belongs to the peptidase M48B family
GM18_RS19680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GM18_RS19685	COG1136	(ABC) transporter
GM18_RS19690	COG0577	efflux transmembrane transporter activity
GM18_RS19710	COG2204	response regulator
GM18_RS19725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GM18_RS19730	COG0438	transferase activity, transferring glycosyl groups
GM18_RS19740	COG0243	molybdopterin cofactor binding
GM18_RS19745	COG0437	4 iron, 4 sulfur cluster binding
GM18_RS19825	COG3344	reverse transcriptase
GM18_RS19840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GM18_RS19850	COG0023	Translation Initiation Factor
GM18_RS19870	COG0113	porphobilinogen synthase activity
GM18_RS19880	COG0181	hydroxymethylbilane synthase activity
GM18_RS19885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GM18_RS19890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GM18_RS19895	COG1648	precorrin-2 dehydrogenase activity
GM18_RS19895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GM18_RS19900	COG3118	belongs to the thioredoxin family
GM18_RS19905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM18_RS19920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GM18_RS19925	COG0058	SHG alpha-glucan phosphorylase activity
GM18_RS19945	COG2205	protein histidine kinase activity
GM18_RS19950	COG0745	RESPONSE REGULATOR receiver
GM18_RS20005	COG1704	LemA family
GM18_RS20030	COG2202	Pas domain
GM18_RS20030	COG2199	diguanylate cyclase activity
GM18_RS20030	COG2200	EAL domain
GM18_RS20040	COG0784	Response regulator, receiver
GM18_RS20045	COG0784	Response regulator, receiver
GM18_RS20050	COG2202	Pas domain
GM18_RS20050	COG2205	protein histidine kinase activity
GM18_RS20060	COG2201	protein-glutamate methylesterase activity
GM18_RS20075	COG0835	chemotaxis
GM18_RS20085	COG0835	chemotaxis
GM18_RS20100	COG0745	RESPONSE REGULATOR receiver
GM18_RS20120	COG0668	transmembrane transport
GM18_RS20130	COG3647	Membrane
GM18_RS20235	COG1073	alpha beta
GM18_RS20245	COG0463	Glycosyl transferase, family 2
GM18_RS20255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM18_RS20265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM18_RS20275	COG1032	radical SAM domain protein
GM18_RS20335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM18_RS20340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM18_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
GM18_RS20425	COG1368	sulfuric ester hydrolase activity
GM18_RS20435	COG1691	(AIR) carboxylase
GM18_RS20440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GM18_RS20445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GM18_RS20450	COG1546	Belongs to the CinA family
GM18_RS20450	COG1058	Belongs to the CinA family
GM18_RS20455	COG5002	protein histidine kinase activity
GM18_RS20460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GM18_RS20470	COG2137	regulation of response to DNA damage stimulus
GM18_RS20480	COG5002	protein histidine kinase activity
GM18_RS20485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GM18_RS20490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GM18_RS20495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GM18_RS20500	COG0137	argininosuccinate synthase activity
GM18_RS20515	COG0165	Argininosuccinate lyase
GM18_RS20525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GM18_RS20530	COG0154	amidase activity
GM18_RS20535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GM18_RS20540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GM18_RS20545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GM18_RS20550	COG0824	Thioesterase
GM18_RS20555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GM18_RS20560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GM18_RS20595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GM18_RS20595	COG1918	ferrous iron import across plasma membrane
GM18_RS20615	COG1136	(ABC) transporter
GM18_RS20620	COG0577	efflux transmembrane transporter activity
GM18_RS20620	COG1136	(ABC) transporter
GM18_RS20625	COG0577	efflux transmembrane transporter activity
GM18_RS20625	COG1136	(ABC) transporter
GM18_RS20640	COG0672	)-iron permease
GM18_RS20660	COG0604	alcohol dehydrogenase
GM18_RS20685	COG0492	ferredoxin-NADP+ reductase activity
GM18_RS20700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GM18_RS20705	COG0514	ATP-dependent DNA helicase (RecQ)
GM18_RS20715	COG1469	GTP cyclohydrolase I activity
GM18_RS20720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GM18_RS20730	COG0358	DNA primase activity
GM18_RS20740	COG1610	YqeY-like protein
GM18_RS20750	COG0140	phosphoribosyl-ATP diphosphatase activity
GM18_RS20755	COG0107	imidazoleglycerol-phosphate synthase activity
GM18_RS20760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GM18_RS20765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GM18_RS20770	COG0131	Imidazoleglycerol-phosphate dehydratase
GM18_RS20775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GM18_RS20780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GM18_RS20790	COG2890	protein-(glutamine-N5) methyltransferase activity
GM18_RS20800	COG3872	metal-dependent enzyme
GM18_RS20805	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GM18_RS20810	COG0254	rRNA binding
GM18_RS20820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GM18_RS20825	COG1408	metallophosphoesterase
GM18_RS20890	COG0463	Glycosyl transferase, family 2
GM18_RS20890	COG0457	Tetratricopeptide repeat
GM18_RS20910	COG5443	negative regulation of bacterial-type flagellum assembly
GM18_RS20940	COG1360	Flagellar Motor Protein
GM18_RS20945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GM18_RS20985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GM18_RS21000	COG4786	Flagellar basal body rod
GM18_RS21005	COG1191	sigma factor activity
GM18_RS21015	COG1419	protein localization to endoplasmic reticulum
GM18_RS21020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GM18_RS21030	COG1242	4 iron, 4 sulfur cluster binding
GM18_RS21035	COG1199	ATP-dependent helicase activity
GM18_RS21040	COG1040	competence protein
GM18_RS21050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GM18_RS21055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GM18_RS21060	COG0799	negative regulation of ribosome biogenesis
GM18_RS21065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GM18_RS21070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GM18_RS21075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GM18_RS21085	COG0306	phosphate transporter
GM18_RS21090	COG1392	Phosphate transport regulator
GM18_RS21155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GM18_RS21165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM18_RS21170	COG0215	cysteine-tRNA ligase activity
GM18_RS21190	COG1122	ATPase activity
GM18_RS21205	COG0310	cobalt ion transport
GM18_RS21210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GM18_RS21215	COG1797	cobyrinic acid a,c-diamide synthase activity
GM18_RS21220	COG0588	phosphoglycerate mutase activity
GM18_RS21225	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GM18_RS21230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GM18_RS21240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GM18_RS21255	COG4191	Histidine kinase
GM18_RS21260	COG2204	response regulator
GM18_RS21270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GM18_RS21275	COG1684	flagellar biosynthetic protein fliR
GM18_RS21285	COG1338	Plays a role in the flagellum-specific transport system
GM18_RS21310	COG4786	Flagellar basal body rod
GM18_RS21320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GM18_RS21340	COG1157	protein secretion by the type III secretion system
GM18_RS21350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GM18_RS21360	COG1677	Flagellar hook-basal body complex protein FliE
GM18_RS21370	COG1815	bacterial-type flagellum-dependent cell motility
GM18_RS21390	COG0745	RESPONSE REGULATOR receiver
GM18_RS21395	COG5002	protein histidine kinase activity
GM18_RS21400	COG0425	Belongs to the sulfur carrier protein TusA family
GM18_RS21400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GM18_RS21405	COG0426	domain, Protein
GM18_RS21405	COG1773	rubredoxin
GM18_RS21420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS21425	COG2852	Protein conserved in bacteria
GM18_RS21455	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GM18_RS21490	COG0463	Glycosyl transferase, family 2
GM18_RS21500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GM18_RS21520	COG0789	Transcriptional regulator
GM18_RS21540	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM18_RS21545	COG0348	domain, Protein
GM18_RS21560	COG0840	transmembrane signaling receptor activity
GM18_RS21560	COG3290	protein histidine kinase activity
GM18_RS21625	COG2337	Toxic component of a toxin-antitoxin (TA) module
GM18_RS21670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GM18_RS21690	COG0700	Nucleoside recognition
GM18_RS21695	COG2715	membrane protein required for spore maturation
GM18_RS21700	COG1619	proteins homologs of microcin C7 resistance protein MccF
GM18_RS21720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GM18_RS21750	COG0840	transmembrane signaling receptor activity
GM18_RS21780	COG3093	addiction module antidote protein HigA
GM18_RS21880	COG1007	ATP synthesis coupled electron transport
GM18_RS21895	COG0713	ATP synthesis coupled electron transport
GM18_RS21900	COG0839	Belongs to the complex I subunit 6 family
GM18_RS21905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS21910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GM18_RS21925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GM18_RS21930	COG0649	NAD binding
GM18_RS21935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS21940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS21945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM18_RS21950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GM18_RS21955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS21970	COG0356	it plays a direct role in the translocation of protons across the membrane
GM18_RS21980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GM18_RS21985	COG0697	spore germination
GM18_RS22000	COG0084	hydrolase, TatD family'
GM18_RS22015	COG0741	lytic transglycosylase activity
GM18_RS22020	COG2204	response regulator
GM18_RS22025	COG0835	chemotaxis
GM18_RS22030	COG2198	Histidine kinase
GM18_RS22030	COG0784	Response regulator, receiver
GM18_RS22030	COG0643	Histidine kinase
GM18_RS22045	COG2201	protein-glutamate methylesterase activity
GM18_RS22060	COG0534	Mate efflux family protein
GM18_RS22065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GM18_RS22070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GM18_RS22075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GM18_RS22080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GM18_RS22085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GM18_RS22090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GM18_RS22100	COG1475	DNA binding
GM18_RS22105	COG1192	Involved in chromosome partitioning
GM18_RS22130	COG0724	RNA recognition motif
GM18_RS22135	COG0322	excinuclease ABC activity
GM18_RS22140	COG1100	Small GTP-binding protein
GM18_RS22150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM18_RS22170	COG0242	peptide deformylase activity
GM18_RS22175	COG3830	Belongs to the UPF0237 family
GM18_RS22185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GM18_RS22205	COG0629	single-stranded DNA binding
GM18_RS22220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM18_RS22245	COG0534	Mate efflux family protein
GM18_RS22255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM18_RS22270	COG3437	response regulator, receiver
GM18_RS22270	COG0784	Response regulator, receiver
GM18_RS22275	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GM18_RS22280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GM18_RS22285	COG4191	Histidine kinase
GM18_RS22310	COG0746	molybdenum cofactor guanylyltransferase activity
GM18_RS22315	COG1763	Mo-molybdopterin cofactor biosynthetic process
GM18_RS22325	COG0303	'Molybdopterin
GM18_RS22340	COG0745	RESPONSE REGULATOR receiver
GM18_RS22350	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GM18_RS22435	COG0583	DNA-binding transcription factor activity
GM18_RS22440	COG1309	transcriptional regulator
GM18_RS22460	COG1136	(ABC) transporter
GM18_RS22460	COG0577	efflux transmembrane transporter activity
GM18_RS22470	COG1342	Belongs to the UPF0251 family
GM18_RS22485	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GM18_RS22490	COG1924	4 iron, 4 sulfur cluster binding
GM18_RS22525	COG0641	radical SAM
GM18_RS22530	COG1272	protein, Hemolysin III
GM18_RS22535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GM18_RS22550	COG0693	protein deglycase activity
GM18_RS22555	COG0436	Aminotransferase
GM18_RS22560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GM18_RS22565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GM18_RS22575	COG0357	Ribosomal RNA small subunit methyltransferase G
GM18_RS22595	COG0706	membrane insertase activity
GM18_RS22600	COG0594	ribonuclease P activity
GM18_RS22605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GM18_RS22625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM18_RS22650	COG5002	protein histidine kinase activity
GM18_RS22655	COG2176	DNA-directed DNA polymerase activity
GM18_RS22655	COG5002	protein histidine kinase activity
GM18_RS22680	COG2205	protein histidine kinase activity
GM18_RS22690	COG0110	maltose O-acetyltransferase activity
GM18_RS22695	COG1216	Glycosyl transferase, family 2
GM18_RS22695	COG1442	glycosyl transferase family 8
GM18_RS22730	COG1215	transferase activity, transferring glycosyl groups
GM18_RS22750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GM18_RS22765	COG4251	negative regulation of phosphorylation
GM18_RS22830	COG1215	transferase activity, transferring glycosyl groups
GM18_RS22840	COG0438	transferase activity, transferring glycosyl groups
GM18_RS22850	COG3447	MASE1 domain protein
GM18_RS22850	COG5002	protein histidine kinase activity
GM18_RS22850	COG5001	Diguanylate cyclase
GM18_RS22855	COG3064	Membrane
GM18_RS22865	COG2204	response regulator
GM18_RS22870	COG0745	RESPONSE REGULATOR receiver
GM18_RS22875	COG4191	Histidine kinase
GM18_RS22890	COG4191	Histidine kinase
GM18_RS22915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GM18_RS22925	COG1620	l-lactate permease
GM18_RS22935	COG4251	negative regulation of phosphorylation
GM18_RS22990	COG3550	peptidyl-serine autophosphorylation
GM18_RS22995	COG3550	peptidyl-serine autophosphorylation
GM18_RS23045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GM18_RS23060	COG2208	phosphoserine phosphatase activity
GM18_RS23110	COG2205	protein histidine kinase activity
GM18_RS23110	COG2202	Pas domain
GM18_RS23115	COG2202	Pas domain
GM18_RS23115	COG2205	protein histidine kinase activity
GM18_RS23135	COG5001	Diguanylate cyclase
GM18_RS23135	COG4251	negative regulation of phosphorylation
GM18_RS23135	COG2203	Gaf domain
GM18_RS23135	COG3706	GGDEF domain
GM18_RS23140	COG1442	glycosyl transferase family 8