locus-tag	class	description
GOBS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GOBS_RS00010	COG0592	DNA-directed DNA polymerase activity
GOBS_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GOBS_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GOBS_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GOBS_RS00035	COG1132	(ABC) transporter
GOBS_RS00040	COG0702	epimerase
GOBS_RS00045	COG0531	amino acid
GOBS_RS00050	COG0187	DNA topoisomerase II activity
GOBS_RS00090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GOBS_RS00105	COG3321	synthase
GOBS_RS00105	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS00105	COG0604	alcohol dehydrogenase
GOBS_RS00115	COG1131	(ABC) transporter
GOBS_RS00135	COG0616	signal peptide processing
GOBS_RS00160	COG0183	Belongs to the thiolase family
GOBS_RS00185	COG0515	serine threonine protein kinase
GOBS_RS00190	COG0768	penicillin binding
GOBS_RS00210	COG1716	ATPase activity
GOBS_RS00230	COG2017	converts alpha-aldose to the beta-anomer
GOBS_RS00250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GOBS_RS00260	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GOBS_RS00270	COG1408	metallophosphoesterase
GOBS_RS00280	COG2188	Transcriptional regulator
GOBS_RS00295	COG2261	transglycosylase associated protein
GOBS_RS00310	COG1024	Enoyl-CoA hydratase
GOBS_RS00315	COG0515	serine threonine protein kinase
GOBS_RS00320	COG0515	serine threonine protein kinase
GOBS_RS00370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GOBS_RS00375	COG2116	formate transmembrane transporter activity
GOBS_RS00425	COG0531	amino acid
GOBS_RS00450	COG1554	hydrolase, family 65, central catalytic
GOBS_RS00460	COG0352	thiamine-phosphate diphosphorylase activity
GOBS_RS00465	COG2022	thiamine diphosphate biosynthetic process
GOBS_RS00475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GOBS_RS00490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GOBS_RS00495	COG1914	H( )-stimulated, divalent metal cation uptake system
GOBS_RS00525	COG2130	NADP-dependent
GOBS_RS00530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOBS_RS00540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOBS_RS00585	COG1846	Transcriptional regulator
GOBS_RS00590	COG1793	dna ligase
GOBS_RS00605	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GOBS_RS00625	COG0277	FAD linked oxidase domain protein
GOBS_RS00645	COG1846	Transcriptional regulator
GOBS_RS00650	COG1132	(ABC) transporter
GOBS_RS00655	COG3764	Sortase (surface protein transpeptidase)
GOBS_RS00665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GOBS_RS00670	COG2200	EAL domain
GOBS_RS00675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS00695	COG2124	cytochrome p450
GOBS_RS00710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GOBS_RS00720	COG0662	Cupin 2, conserved barrel domain protein
GOBS_RS00725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GOBS_RS00735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOBS_RS00740	COG0439	Biotin carboxylase
GOBS_RS00745	COG0511	ligase activity, forming carbon-carbon bonds
GOBS_RS00750	COG0825	malonyl-CoA metabolic process
GOBS_RS00750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GOBS_RS00760	COG2197	response regulator
GOBS_RS00765	COG2197	response regulator
GOBS_RS00770	COG1902	pentaerythritol trinitrate reductase activity
GOBS_RS00790	COG0577	efflux transmembrane transporter activity
GOBS_RS00790	COG1136	(ABC) transporter
GOBS_RS00840	COG2233	PERMEase
GOBS_RS00845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GOBS_RS00850	COG1304	FMN binding
GOBS_RS00860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GOBS_RS00865	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GOBS_RS00875	COG0840	transmembrane signaling receptor activity
GOBS_RS00885	COG0549	Belongs to the carbamate kinase family
GOBS_RS00930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GOBS_RS00935	COG0831	urea catabolic process
GOBS_RS00945	COG0804	urea catabolic process
GOBS_RS00950	COG0830	nickel cation binding
GOBS_RS00955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GOBS_RS00960	COG0829	nickel cation binding
GOBS_RS00965	COG4266	Belongs to the allantoicase family
GOBS_RS00980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GOBS_RS01000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GOBS_RS01005	COG0121	glutamine amidotransferase
GOBS_RS01010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GOBS_RS01015	COG3572	ergothioneine biosynthetic process
GOBS_RS01055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GOBS_RS01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GOBS_RS01090	COG3546	catalase activity
GOBS_RS01115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GOBS_RS01120	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GOBS_RS01130	COG0463	Glycosyl transferase, family 2
GOBS_RS01135	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS01140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GOBS_RS01165	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS01175	COG0653	protein targeting
GOBS_RS01180	COG4213	ABC transporter substrate-binding protein
GOBS_RS01190	COG4214	carbohydrate transport
GOBS_RS01195	COG1609	Transcriptional regulator
GOBS_RS01210	COG2160	L-arabinose isomerase activity
GOBS_RS01235	COG0277	FAD linked oxidase domain protein
GOBS_RS01240	COG0247	lactate metabolic process
GOBS_RS01255	COG0789	Transcriptional regulator
GOBS_RS01260	COG2318	DinB family
GOBS_RS01275	COG0842	Transport permease protein
GOBS_RS01280	COG1131	(ABC) transporter
GOBS_RS01290	COG2119	membrane
GOBS_RS01315	COG3706	GGDEF domain
GOBS_RS01320	COG0077	Prephenate dehydratase
GOBS_RS01325	COG2409	Drug exporters of the RND superfamily
GOBS_RS01330	COG1846	Transcriptional regulator
GOBS_RS01335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GOBS_RS01350	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS01360	COG0745	RESPONSE REGULATOR receiver
GOBS_RS01365	COG0784	Response regulator, receiver
GOBS_RS01365	COG2205	protein histidine kinase activity
GOBS_RS01365	COG5002	protein histidine kinase activity
GOBS_RS01375	COG0561	phosphatase activity
GOBS_RS01380	COG0561	phosphatase activity
GOBS_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS01430	COG0604	alcohol dehydrogenase
GOBS_RS01430	COG3321	synthase
GOBS_RS01445	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS01455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GOBS_RS01470	COG0776	regulation of translation
GOBS_RS01475	COG0667	Aldo Keto reductase
GOBS_RS01480	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GOBS_RS01495	COG2860	membrane
GOBS_RS01515	COG0183	Belongs to the thiolase family
GOBS_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS01530	COG3250	beta-galactosidase activity
GOBS_RS01545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOBS_RS01555	COG4608	Belongs to the ABC transporter superfamily
GOBS_RS01570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOBS_RS01610	COG0589	response to stress
GOBS_RS01630	COG3706	GGDEF domain
GOBS_RS01635	COG0644	oxidoreductase
GOBS_RS01685	COG0463	Glycosyl transferase, family 2
GOBS_RS01690	COG0463	Glycosyl transferase, family 2
GOBS_RS01705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GOBS_RS01715	COG0243	molybdopterin cofactor binding
GOBS_RS01715	COG3383	formate dehydrogenase (NAD+) activity
GOBS_RS01720	COG3383	formate dehydrogenase (NAD+) activity
GOBS_RS01720	COG0243	molybdopterin cofactor binding
GOBS_RS01725	COG0437	4 iron, 4 sulfur cluster binding
GOBS_RS01790	COG0489	protein tyrosine kinase activity
GOBS_RS01845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GOBS_RS01880	COG3328	transposase activity
GOBS_RS01900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOBS_RS01925	COG1472	Belongs to the glycosyl hydrolase 3 family
GOBS_RS01975	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS01990	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS02015	COG0297	glycogen (starch) synthase activity
GOBS_RS02060	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS02070	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS02085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GOBS_RS02140	COG1216	Glycosyl transferase, family 2
GOBS_RS02205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOBS_RS02225	COG1216	Glycosyl transferase, family 2
GOBS_RS02230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GOBS_RS02230	COG1796	DNA polymerase
GOBS_RS02240	COG0671	phosphoesterase, PA-phosphatase related
GOBS_RS02280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GOBS_RS02295	COG0297	glycogen (starch) synthase activity
GOBS_RS02300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GOBS_RS02305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GOBS_RS02305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GOBS_RS02320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOBS_RS02330	COG0287	Prephenate dehydrogenase
GOBS_RS02355	COG0037	tRNA processing
GOBS_RS02355	COG0590	tRNA wobble adenosine to inosine editing
GOBS_RS02365	COG2815	serine threonine protein kinase
GOBS_RS02365	COG0515	serine threonine protein kinase
GOBS_RS02405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GOBS_RS02410	COG0747	negative chemotaxis
GOBS_RS02415	COG0601	transmembrane transport
GOBS_RS02420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOBS_RS02430	COG4608	Belongs to the ABC transporter superfamily
GOBS_RS02450	COG3467	pyridoxamine 5'-phosphate
GOBS_RS02470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GOBS_RS02475	COG0488	(ABC) transporter
GOBS_RS02480	COG2111	Na H antiporter
GOBS_RS02480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GOBS_RS02485	COG1006	Multisubunit Na H antiporter MnhC subunit
GOBS_RS02490	COG0651	ATP synthesis coupled electron transport
GOBS_RS02500	COG2212	antiporter activity
GOBS_RS02505	COG1320	monovalent cation:proton antiporter activity
GOBS_RS02515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GOBS_RS02550	COG1253	flavin adenine dinucleotide binding
GOBS_RS02560	COG1408	metallophosphoesterase
GOBS_RS02570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOBS_RS02605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GOBS_RS02615	COG0494	nUDIX hydrolase
GOBS_RS02630	COG0596	Alpha beta hydrolase
GOBS_RS02640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOBS_RS02650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GOBS_RS02655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GOBS_RS02660	COG4221	oxidoreductase activity
GOBS_RS02665	COG0789	Transcriptional regulator
GOBS_RS02670	COG3384	dioxygenase
GOBS_RS02675	COG1476	TRANSCRIPTIONal
GOBS_RS02690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GOBS_RS02690	COG1648	precorrin-2 dehydrogenase activity
GOBS_RS02695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GOBS_RS02720	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GOBS_RS02725	COG0310	cobalt ion transport
GOBS_RS02730	COG1797	cobyrinic acid a,c-diamide synthase activity
GOBS_RS02755	COG3180	Ammonia monooxygenase
GOBS_RS02795	COG1492	cobalamin metabolic process
GOBS_RS02800	COG0204	Acyl-transferase
GOBS_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS02810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GOBS_RS02815	COG0242	peptide deformylase activity
GOBS_RS02865	COG2814	Major facilitator Superfamily
GOBS_RS02925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GOBS_RS02935	COG0406	alpha-ribazole phosphatase activity
GOBS_RS02995	COG1396	sequence-specific DNA binding
GOBS_RS03005	COG1205	dead DEAH box helicase
GOBS_RS03005	COG1111	helicase
GOBS_RS03010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GOBS_RS03025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GOBS_RS03025	COG1754	DNA topoisomerase type I activity
GOBS_RS03040	COG4106	trans-aconitate 2-methyltransferase activity
GOBS_RS03045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GOBS_RS03050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GOBS_RS03060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GOBS_RS03065	COG2027	D-alanyl-D-alanine carboxypeptidase
GOBS_RS03075	COG0037	tRNA processing
GOBS_RS03080	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GOBS_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GOBS_RS03100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GOBS_RS03120	COG1174	glycine betaine transport
GOBS_RS03165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GOBS_RS03170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GOBS_RS03175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GOBS_RS03185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GOBS_RS03190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GOBS_RS03225	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GOBS_RS03230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GOBS_RS03240	COG3046	protein related to deoxyribodipyrimidine photolyase
GOBS_RS03260	COG1329	Transcriptional regulator
GOBS_RS03265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GOBS_RS03270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GOBS_RS03275	COG0215	cysteine-tRNA ligase activity
GOBS_RS03290	COG2733	membrane
GOBS_RS03295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GOBS_RS03455	COG1196	nuclear chromosome segregation
GOBS_RS03455	COG0741	lytic transglycosylase activity
GOBS_RS03455	COG0739	heme binding
GOBS_RS03485	COG2826	transposase and inactivated derivatives, IS30 family
GOBS_RS03495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOBS_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS03705	COG0358	DNA primase activity
GOBS_RS03755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GOBS_RS03820	COG0642	Histidine kinase
GOBS_RS03825	COG0745	RESPONSE REGULATOR receiver
GOBS_RS03835	COG3360	Dodecin
GOBS_RS03895	COG0459	protein refolding
GOBS_RS03935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOBS_RS03940	COG0477	Major facilitator Superfamily
GOBS_RS03945	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GOBS_RS03945	COG1672	PFAM Archaeal ATPase
GOBS_RS03985	COG1061	Type III restriction enzyme res subunit
GOBS_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS04025	COG2149	membrane
GOBS_RS04030	COG1278	Cold shock
GOBS_RS04040	COG2814	Major facilitator Superfamily
GOBS_RS04050	COG0477	Major facilitator Superfamily
GOBS_RS04055	COG2252	PERMEase
GOBS_RS04065	COG2211	Major facilitator Superfamily
GOBS_RS04085	COG0667	Aldo Keto reductase
GOBS_RS04100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GOBS_RS04115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GOBS_RS04125	COG0259	pyridoxamine-phosphate oxidase activity
GOBS_RS04130	COG0477	Major facilitator Superfamily
GOBS_RS04135	COG1764	response to oxidative stress
GOBS_RS04140	COG1573	uracil-dna glycosylase
GOBS_RS04145	COG4152	abc transporter atp-binding protein
GOBS_RS04160	COG3764	Sortase (surface protein transpeptidase)
GOBS_RS04165	COG3386	PFAM SMP-30 Gluconolaconase
GOBS_RS04170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GOBS_RS04210	COG0415	Belongs to the DNA photolyase family
GOBS_RS04225	COG0596	Alpha beta hydrolase
GOBS_RS04245	COG3903	Transcriptional regulator
GOBS_RS04245	COG3629	intracellular signal transduction
GOBS_RS04280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GOBS_RS04295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GOBS_RS04375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GOBS_RS04380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GOBS_RS04390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GOBS_RS04440	COG1024	Enoyl-CoA hydratase
GOBS_RS04460	COG0598	Magnesium transport protein CorA
GOBS_RS04465	COG0531	amino acid
GOBS_RS04475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOBS_RS04480	COG0084	hydrolase, TatD family'
GOBS_RS04495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GOBS_RS04500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GOBS_RS04505	COG1309	transcriptional regulator
GOBS_RS04520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GOBS_RS04525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GOBS_RS04530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GOBS_RS04540	COG0193	aminoacyl-tRNA hydrolase activity
GOBS_RS04550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOBS_RS04565	COG3956	TIGRFAM MazG family protein
GOBS_RS04570	COG0148	phosphopyruvate hydratase activity
GOBS_RS04600	COG1252	NADH dehydrogenase
GOBS_RS04620	COG0183	Belongs to the thiolase family
GOBS_RS04645	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GOBS_RS04650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GOBS_RS04675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GOBS_RS04680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GOBS_RS04700	COG1331	Highly conserved protein containing a thioredoxin domain
GOBS_RS04715	COG0644	oxidoreductase
GOBS_RS04725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GOBS_RS04735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GOBS_RS04755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GOBS_RS04765	COG1684	flagellar biosynthetic protein fliR
GOBS_RS04785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GOBS_RS04785	COG1776	CheC inhibitor of MCP methylation
GOBS_RS04790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GOBS_RS04805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GOBS_RS04830	COG1196	nuclear chromosome segregation
GOBS_RS04830	COG0739	heme binding
GOBS_RS04830	COG0741	lytic transglycosylase activity
GOBS_RS04840	COG1157	protein secretion by the type III secretion system
GOBS_RS04850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GOBS_RS04855	COG1766	The M ring may be actively involved in energy transduction
GOBS_RS04860	COG1677	Flagellar hook-basal body complex protein FliE
GOBS_RS04890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GOBS_RS04900	COG1191	sigma factor activity
GOBS_RS04910	COG4786	Flagellar basal body rod
GOBS_RS04910	COG1256	bacterial-type flagellum assembly
GOBS_RS04915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GOBS_RS04925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GOBS_RS04965	COG0114	fumarate hydratase activity
GOBS_RS04990	COG1722	exodeoxyribonuclease VII activity
GOBS_RS04995	COG1570	exodeoxyribonuclease VII activity
GOBS_RS05015	COG1322	Protein conserved in bacteria
GOBS_RS05020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GOBS_RS05040	COG1309	transcriptional regulator
GOBS_RS05060	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS05080	COG0673	inositol 2-dehydrogenase activity
GOBS_RS05100	COG1131	(ABC) transporter
GOBS_RS05115	COG2197	response regulator
GOBS_RS05135	COG0012	GTP binding
GOBS_RS05170	COG2072	flavoprotein involved in K transport
GOBS_RS05180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOBS_RS05200	COG0604	alcohol dehydrogenase
GOBS_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS05200	COG3321	synthase
GOBS_RS05210	COG0667	Aldo Keto reductase
GOBS_RS05230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GOBS_RS05235	COG1053	succinate dehydrogenase
GOBS_RS05245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GOBS_RS05250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GOBS_RS05250	COG1017	nitric oxide dioxygenase activity
GOBS_RS05275	COG2116	formate transmembrane transporter activity
GOBS_RS05315	COG3848	Pyruvate phosphate dikinase
GOBS_RS05315	COG0574	Belongs to the PEP-utilizing enzyme family
GOBS_RS05320	COG2890	protein-(glutamine-N5) methyltransferase activity
GOBS_RS05325	COG2154	pterin-4-alpha-carbinolamine dehydratase
GOBS_RS05330	COG0175	sulfate reduction
GOBS_RS05345	COG0529	Catalyzes the synthesis of activated sulfate
GOBS_RS05355	COG0494	nUDIX hydrolase
GOBS_RS05370	COG0601	transmembrane transport
GOBS_RS05375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOBS_RS05380	COG0444	Belongs to the ABC transporter superfamily
GOBS_RS05385	COG4608	Belongs to the ABC transporter superfamily
GOBS_RS05390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GOBS_RS05430	COG2171	N-acyltransferase activity
GOBS_RS05435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOBS_RS05440	COG1611	Belongs to the LOG family
GOBS_RS05475	COG5297	Belongs to the glycosyl hydrolase family 6
GOBS_RS05475	COG4733	cellulase activity
GOBS_RS05480	COG0519	Catalyzes the synthesis of GMP from XMP
GOBS_RS05485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GOBS_RS05520	COG0681	Belongs to the peptidase S26 family
GOBS_RS05530	COG2132	Multicopper oxidase
GOBS_RS05540	COG2197	response regulator
GOBS_RS05545	COG2197	response regulator
GOBS_RS05560	COG0297	glycogen (starch) synthase activity
GOBS_RS05565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GOBS_RS05580	COG1595	DNA-templated transcription, initiation
GOBS_RS05590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GOBS_RS05595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GOBS_RS05635	COG2239	Acts as a magnesium transporter
GOBS_RS05650	COG2301	Belongs to the HpcH HpaI aldolase family
GOBS_RS05660	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS05670	COG0604	alcohol dehydrogenase
GOBS_RS05670	COG3321	synthase
GOBS_RS05680	COG0028	Belongs to the TPP enzyme family
GOBS_RS05700	COG1752	Esterase of the alpha-beta hydrolase superfamily
GOBS_RS05700	COG1752	Esterase of the alpha-beta hydrolase superfamily
GOBS_RS05710	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GOBS_RS05750	COG2319	Wd-40 repeat
GOBS_RS05750	COG4249	Peptidase C14 caspase catalytic subunit p20
GOBS_RS05775	COG3629	intracellular signal transduction
GOBS_RS05775	COG3903	Transcriptional regulator
GOBS_RS05855	COG2234	aminopeptidase activity
GOBS_RS05920	COG2963	transposase activity
GOBS_RS05925	COG2801	Transposase and inactivated derivatives
GOBS_RS05940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GOBS_RS06005	COG0753	catalase activity
GOBS_RS06015	COG2909	trisaccharide binding
GOBS_RS06045	COG1752	Esterase of the alpha-beta hydrolase superfamily
GOBS_RS06070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GOBS_RS06075	COG2884	Cell division ATP-binding protein ftsE
GOBS_RS06080	COG2177	Part of the ABC transporter FtsEX involved in
GOBS_RS06085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GOBS_RS06105	COG2267	carboxylic ester hydrolase activity
GOBS_RS06140	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GOBS_RS06145	COG0598	Magnesium transport protein CorA
GOBS_RS06175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GOBS_RS06190	COG0584	glycerophosphoryl diester phosphodiesterase
GOBS_RS06195	COG3629	intracellular signal transduction
GOBS_RS06195	COG3903	Transcriptional regulator
GOBS_RS06215	COG2353	YceI-like domain
GOBS_RS06220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOBS_RS06235	COG1217	gtp-binding protein TYPA
GOBS_RS06255	COG0730	response to heat
GOBS_RS06280	COG1999	signal sequence binding
GOBS_RS06295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GOBS_RS06305	COG0246	Mannitol dehydrogenase
GOBS_RS06310	COG0739	heme binding
GOBS_RS06345	COG0251	oxidation-reduction process
GOBS_RS06360	COG4829	muconolactone delta-isomerase
GOBS_RS06365	COG3485	protocatechuate 3,4-dioxygenase
GOBS_RS06375	COG0583	DNA-binding transcription factor activity
GOBS_RS06380	COG4638	Rieske (2fe-2S)
GOBS_RS06400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS06400	COG0596	Alpha beta hydrolase
GOBS_RS06400	COG2226	methyltransferase
GOBS_RS06420	COG1584	GPR1 FUN34 yaaH family protein
GOBS_RS06425	COG2208	phosphoserine phosphatase activity
GOBS_RS06425	COG2770	Histidine kinase
GOBS_RS06455	COG0385	Bile acid
GOBS_RS06470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOBS_RS06475	COG0745	RESPONSE REGULATOR receiver
GOBS_RS06485	COG5002	protein histidine kinase activity
GOBS_RS06490	COG0745	RESPONSE REGULATOR receiver
GOBS_RS06520	COG2116	formate transmembrane transporter activity
GOBS_RS06530	COG0754	glutathionylspermidine amidase activity
GOBS_RS06580	COG0488	(ABC) transporter
GOBS_RS06590	COG0667	Aldo Keto reductase
GOBS_RS06595	COG2814	Major facilitator Superfamily
GOBS_RS06605	COG0739	heme binding
GOBS_RS06640	COG0560	Phosphoserine phosphatase
GOBS_RS06640	COG3830	Belongs to the UPF0237 family
GOBS_RS06645	COG1335	isochorismatase
GOBS_RS06655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GOBS_RS06685	COG1234	tRNA 3'-trailer cleavage
GOBS_RS06690	COG1793	dna ligase
GOBS_RS06690	COG3285	dna ligase
GOBS_RS06710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GOBS_RS06760	COG0667	Aldo Keto reductase
GOBS_RS06770	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS06785	COG0477	Major facilitator Superfamily
GOBS_RS06800	COG0596	Alpha beta hydrolase
GOBS_RS06805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GOBS_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS06865	COG0346	lactoylglutathione lyase activity
GOBS_RS06880	COG0464	growth
GOBS_RS06890	COG1597	lipid kinase activity
GOBS_RS06935	COG3903	Transcriptional regulator
GOBS_RS06935	COG3629	intracellular signal transduction
GOBS_RS06945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOBS_RS06975	COG1476	TRANSCRIPTIONal
GOBS_RS06980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GOBS_RS06985	COG0596	Alpha beta hydrolase
GOBS_RS06990	COG4251	negative regulation of phosphorylation
GOBS_RS07015	COG0506	proline dehydrogenase activity
GOBS_RS07020	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS07030	COG2226	methyltransferase
GOBS_RS07050	COG1131	(ABC) transporter
GOBS_RS07055	COG2072	flavoprotein involved in K transport
GOBS_RS07110	COG0235	Class ii aldolase
GOBS_RS07115	COG2186	Transcriptional regulator
GOBS_RS07125	COG1850	ribulose-bisphosphate carboxylase activity
GOBS_RS07135	COG1063	alcohol dehydrogenase
GOBS_RS07180	COG1376	ErfK ybiS ycfS ynhG family protein
GOBS_RS07225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GOBS_RS07245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GOBS_RS07250	COG1528	Iron-storage protein
GOBS_RS07265	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS07270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GOBS_RS07275	COG1929	Belongs to the glycerate kinase type-1 family
GOBS_RS07280	COG1063	alcohol dehydrogenase
GOBS_RS07300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GOBS_RS07310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GOBS_RS07320	COG1131	(ABC) transporter
GOBS_RS07335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GOBS_RS07355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS07395	COG1715	Restriction endonuclease
GOBS_RS07475	COG2204	response regulator
GOBS_RS07490	COG0629	single-stranded DNA binding
GOBS_RS07510	COG3304	Inner membrane component domain
GOBS_RS07520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GOBS_RS07525	COG1122	ATPase activity
GOBS_RS07530	COG1268	BioY protein
GOBS_RS07540	COG1129	ABC transporter
GOBS_RS07545	COG0366	Alpha amylase catalytic
GOBS_RS07560	COG0668	transmembrane transport
GOBS_RS07565	COG1505	serine-type exopeptidase activity
GOBS_RS07620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GOBS_RS07645	COG4552	Acetyltransferase involved in intracellular survival and related
GOBS_RS07675	COG5006	permease, DMT superfamily
GOBS_RS07680	COG1606	tRNA processing
GOBS_RS07685	COG3875	lactate racemase activity
GOBS_RS07690	COG1691	(AIR) carboxylase
GOBS_RS07695	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GOBS_RS07760	COG0693	protein deglycase activity
GOBS_RS07780	COG0544	peptidyl-prolyl cis-trans isomerase activity
GOBS_RS07785	COG0740	serine-type endopeptidase activity
GOBS_RS07790	COG0740	serine-type endopeptidase activity
GOBS_RS07795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GOBS_RS07805	COG0525	valine-tRNA ligase activity
GOBS_RS07810	COG0285	dihydrofolate synthase activity
GOBS_RS07820	COG0105	UTP biosynthetic process
GOBS_RS07835	COG1530	ribonuclease E activity
GOBS_RS07840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GOBS_RS07845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GOBS_RS07850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GOBS_RS07855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GOBS_RS07860	COG0242	peptide deformylase activity
GOBS_RS07865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GOBS_RS07900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GOBS_RS07905	COG1121	(ABC) transporter
GOBS_RS07915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GOBS_RS07920	COG0542	response to heat
GOBS_RS07930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GOBS_RS07935	COG0799	negative regulation of ribosome biogenesis
GOBS_RS07940	COG0406	alpha-ribazole phosphatase activity
GOBS_RS07945	COG1307	EDD domain protein, DegV family
GOBS_RS07975	COG0268	Binds directly to 16S ribosomal RNA
GOBS_RS07990	COG2258	MOSC domain
GOBS_RS08010	COG0542	response to heat
GOBS_RS08025	COG0604	alcohol dehydrogenase
GOBS_RS08030	COG0709	Synthesizes selenophosphate from selenide and ATP
GOBS_RS08040	COG0747	negative chemotaxis
GOBS_RS08055	COG1921	L-seryl-tRNASec selenium transferase activity
GOBS_RS08070	COG1024	Enoyl-CoA hydratase
GOBS_RS08080	COG1131	(ABC) transporter
GOBS_RS08090	COG4585	Histidine kinase
GOBS_RS08095	COG2197	response regulator
GOBS_RS08105	COG1420	regulation of RNA biosynthetic process
GOBS_RS08110	COG0484	heat shock protein binding
GOBS_RS08130	COG3639	organic phosphonate transmembrane transporter activity
GOBS_RS08135	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GOBS_RS08140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GOBS_RS08165	COG0537	adenosine 5'-monophosphoramidase activity
GOBS_RS08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GOBS_RS08200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GOBS_RS08205	COG1381	Involved in DNA repair and RecF pathway recombination
GOBS_RS08210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GOBS_RS08225	COG0423	glycine-tRNA ligase activity
GOBS_RS08250	COG0574	Belongs to the PEP-utilizing enzyme family
GOBS_RS08250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GOBS_RS08330	COG0604	alcohol dehydrogenase
GOBS_RS08360	COG1937	Protein conserved in bacteria
GOBS_RS08370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOBS_RS08380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GOBS_RS08390	COG0713	ATP synthesis coupled electron transport
GOBS_RS08400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOBS_RS08405	COG1007	ATP synthesis coupled electron transport
GOBS_RS08415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GOBS_RS08420	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GOBS_RS08425	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS08430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GOBS_RS08460	COG3959	Transketolase, thiamine diphosphate binding domain
GOBS_RS08465	COG3958	Transketolase
GOBS_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS08500	COG2902	Dehydrogenase
GOBS_RS08530	COG0531	amino acid
GOBS_RS08535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GOBS_RS08595	COG0010	Belongs to the arginase family
GOBS_RS08605	COG2409	Drug exporters of the RND superfamily
GOBS_RS08610	COG1309	transcriptional regulator
GOBS_RS08635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GOBS_RS08640	COG0515	serine threonine protein kinase
GOBS_RS08645	COG1556	Lactate utilization protein
GOBS_RS08650	COG1139	Iron-sulfur cluster binding protein
GOBS_RS08655	COG0247	lactate metabolic process
GOBS_RS08660	COG1609	Transcriptional regulator
GOBS_RS08750	COG3300	MHYT domain
GOBS_RS08750	COG5001	Diguanylate cyclase
GOBS_RS08775	COG0657	acetylesterase activity
GOBS_RS08800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GOBS_RS08810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GOBS_RS08825	COG0366	Alpha amylase catalytic
GOBS_RS08860	COG0477	Major facilitator Superfamily
GOBS_RS08865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GOBS_RS08865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GOBS_RS08900	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS08920	COG0515	serine threonine protein kinase
GOBS_RS08950	COG0531	amino acid
GOBS_RS08955	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS08975	COG3973	AAA domain
GOBS_RS09010	COG1063	alcohol dehydrogenase
GOBS_RS09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS09030	COG2072	flavoprotein involved in K transport
GOBS_RS09040	COG0657	acetylesterase activity
GOBS_RS09045	COG2072	flavoprotein involved in K transport
GOBS_RS09125	COG3321	synthase
GOBS_RS09125	COG0604	alcohol dehydrogenase
GOBS_RS09130	COG3328	transposase activity
GOBS_RS09140	COG2130	NADP-dependent
GOBS_RS09145	COG3903	Transcriptional regulator
GOBS_RS09145	COG3629	intracellular signal transduction
GOBS_RS09190	COG0756	dUTP diphosphatase activity
GOBS_RS09220	COG0569	domain protein
GOBS_RS09225	COG0531	amino acid
GOBS_RS09230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GOBS_RS09250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GOBS_RS09255	COG0011	TIGRFAM Protein of
GOBS_RS09260	COG1024	Enoyl-CoA hydratase
GOBS_RS09260	COG1250	3-hydroxyacyl-CoA dehydrogenase
GOBS_RS09265	COG0183	Belongs to the thiolase family
GOBS_RS09270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GOBS_RS09280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GOBS_RS09285	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GOBS_RS09290	COG3253	May function as heme-dependent peroxidase
GOBS_RS09305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOBS_RS09315	COG1278	Cold shock
GOBS_RS09350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GOBS_RS09355	COG2151	metal-sulfur cluster biosynthetic enzyme
GOBS_RS09360	COG3396	Phenylacetate-CoA oxygenase
GOBS_RS09365	COG3460	Phenylacetate-CoA oxygenase
GOBS_RS09370	COG3396	Phenylacetate-CoA oxygenase
GOBS_RS09385	COG2030	dehydratase
GOBS_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS09390	COG2124	cytochrome p450
GOBS_RS09395	COG1250	3-hydroxyacyl-CoA dehydrogenase
GOBS_RS09400	COG0477	Major facilitator Superfamily
GOBS_RS09405	COG1414	Transcriptional regulator
GOBS_RS09430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOBS_RS09440	COG3226	Transcriptional regulator
GOBS_RS09465	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GOBS_RS09480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GOBS_RS09485	COG0686	Belongs to the AlaDH PNT family
GOBS_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS09520	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS09525	COG2026	Addiction module toxin, RelE StbE family
GOBS_RS09555	COG1793	dna ligase
GOBS_RS09590	COG1136	(ABC) transporter
GOBS_RS09590	COG0577	efflux transmembrane transporter activity
GOBS_RS09595	COG1136	(ABC) transporter
GOBS_RS09595	COG0577	efflux transmembrane transporter activity
GOBS_RS09600	COG1652	LysM domain
GOBS_RS09630	COG1506	peptidase
GOBS_RS09630	COG0823	Involved in the tonB-independent uptake of proteins
GOBS_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS09655	COG0702	epimerase
GOBS_RS09720	COG4585	Histidine kinase
GOBS_RS09725	COG2197	response regulator
GOBS_RS09730	COG2909	trisaccharide binding
GOBS_RS09735	COG2814	Major facilitator Superfamily
GOBS_RS09845	COG3384	dioxygenase
GOBS_RS09850	COG0702	epimerase
GOBS_RS09855	COG4585	Histidine kinase
GOBS_RS09860	COG2197	response regulator
GOBS_RS09900	COG0235	Class ii aldolase
GOBS_RS09905	COG2186	Transcriptional regulator
GOBS_RS09915	COG1850	ribulose-bisphosphate carboxylase activity
GOBS_RS09925	COG1063	alcohol dehydrogenase
GOBS_RS09965	COG0154	amidase activity
GOBS_RS09975	COG3268	Saccharopine dehydrogenase
GOBS_RS09990	COG0322	excinuclease ABC activity
GOBS_RS09995	COG1660	Displays ATPase and GTPase activities
GOBS_RS10000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GOBS_RS10005	COG1481	regulation of sporulation
GOBS_RS10010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GOBS_RS10015	COG0126	phosphoglycerate kinase activity
GOBS_RS10020	COG0149	triose-phosphate isomerase activity
GOBS_RS10040	COG0363	glucosamine-6-phosphate deaminase activity
GOBS_RS10055	COG0166	Belongs to the GPI family
GOBS_RS10060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GOBS_RS10070	COG0109	protoheme IX farnesyltransferase activity
GOBS_RS10080	COG0542	response to heat
GOBS_RS10095	COG0719	Fe-S assembly protein
GOBS_RS10105	COG0396	ATPase activity
GOBS_RS10115	COG0822	iron-sulfur transferase activity
GOBS_RS10120	COG2151	metal-sulfur cluster biosynthetic enzyme
GOBS_RS10135	COG0488	(ABC) transporter
GOBS_RS10145	COG1024	Enoyl-CoA hydratase
GOBS_RS10150	COG1132	(ABC) transporter
GOBS_RS10160	COG2076	Multidrug Resistance protein
GOBS_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS10175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GOBS_RS10180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GOBS_RS10195	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS10200	COG3883	PFAM NLP P60 protein
GOBS_RS10200	COG0791	NLP P60 protein
GOBS_RS10205	COG0714	Associated with various cellular activities
GOBS_RS10215	COG2304	oxidoreductase activity
GOBS_RS10240	COG0154	amidase activity
GOBS_RS10245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GOBS_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS10275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GOBS_RS10285	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS10295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GOBS_RS10330	COG2172	sigma factor antagonist activity
GOBS_RS10345	COG1366	Belongs to the anti-sigma-factor antagonist family
GOBS_RS10360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GOBS_RS10370	COG3285	dna ligase
GOBS_RS10370	COG1793	dna ligase
GOBS_RS10375	COG0788	formyltetrahydrofolate deformylase activity
GOBS_RS10390	COG0753	catalase activity
GOBS_RS10395	COG2814	Major facilitator Superfamily
GOBS_RS10435	COG0628	permease
GOBS_RS10520	COG1070	Carbohydrate kinase
GOBS_RS10525	COG0069	glutamate synthase activity
GOBS_RS10530	COG0431	NADPH-dependent FMN reductase
GOBS_RS10575	COG1742	UPF0060 membrane protein
GOBS_RS10580	COG2264	protein methyltransferase activity
GOBS_RS10615	COG1357	PFAM Pentapeptide repeats (8 copies)
GOBS_RS10630	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GOBS_RS10635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GOBS_RS10655	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS10660	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS10675	COG3706	GGDEF domain
GOBS_RS10690	COG1414	Transcriptional regulator
GOBS_RS10695	COG3485	protocatechuate 3,4-dioxygenase
GOBS_RS10700	COG3485	protocatechuate 3,4-dioxygenase
GOBS_RS10710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS10715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GOBS_RS10740	COG2807	transmembrane transport
GOBS_RS10745	COG1984	allophanate hydrolase subunit 2
GOBS_RS10750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GOBS_RS10755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GOBS_RS10760	COG1914	H( )-stimulated, divalent metal cation uptake system
GOBS_RS10765	COG4336	lyase activity
GOBS_RS10770	COG0137	argininosuccinate synthase activity
GOBS_RS10775	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GOBS_RS10800	COG1063	alcohol dehydrogenase
GOBS_RS10815	COG2318	DinB family
GOBS_RS10840	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS10855	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GOBS_RS10860	COG0215	cysteine-tRNA ligase activity
GOBS_RS10870	COG0398	Pfam SNARE associated Golgi protein
GOBS_RS10875	COG1280	lysine exporter protein (LysE YggA)
GOBS_RS10885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GOBS_RS10885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GOBS_RS10885	COG1703	isobutyryl-CoA mutase activity
GOBS_RS10900	COG3599	regulation of cell shape
GOBS_RS10915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GOBS_RS10925	COG2353	YceI-like domain
GOBS_RS10980	COG0205	6-phosphofructokinase activity
GOBS_RS10985	COG0189	ligase activity
GOBS_RS10985	COG2918	glutathione biosynthetic process
GOBS_RS10995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GOBS_RS11000	COG0477	Major facilitator Superfamily
GOBS_RS11015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOBS_RS11045	COG1301	dicarboxylic acid transport
GOBS_RS11050	COG3290	protein histidine kinase activity
GOBS_RS11055	COG4565	transcriptional regulatory protein
GOBS_RS11085	COG0583	DNA-binding transcription factor activity
GOBS_RS11100	COG1234	tRNA 3'-trailer cleavage
GOBS_RS11115	COG0456	acetyltransferase
GOBS_RS11140	COG0446	pyridine nucleotide-disulphide oxidoreductase
GOBS_RS11205	COG4702	Belongs to the UPF0303 family
GOBS_RS11225	COG3483	tryptophan 2,3-dioxygenase activity
GOBS_RS11255	COG0366	Alpha amylase catalytic
GOBS_RS11290	COG0697	spore germination
GOBS_RS11325	COG2423	ornithine cyclodeaminase activity
GOBS_RS11335	COG0531	amino acid
GOBS_RS11385	COG1017	nitric oxide dioxygenase activity
GOBS_RS11385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GOBS_RS11390	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS11410	COG0405	Gamma-glutamyltransferase
GOBS_RS11420	COG4133	protoheme IX ABC transporter activity
GOBS_RS11455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS11475	COG1793	dna ligase
GOBS_RS11480	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GOBS_RS11480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GOBS_RS11480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GOBS_RS11485	COG1461	Dihydroxyacetone kinase
GOBS_RS11490	COG2376	Dihydroxyacetone kinase
GOBS_RS11505	COG0745	RESPONSE REGULATOR receiver
GOBS_RS11515	COG4326	sporulation control protein
GOBS_RS11540	COG2072	flavoprotein involved in K transport
GOBS_RS11545	COG2508	Transcriptional regulator
GOBS_RS11560	COG2409	Drug exporters of the RND superfamily
GOBS_RS11580	COG2267	carboxylic ester hydrolase activity
GOBS_RS11600	COG2814	Major facilitator Superfamily
GOBS_RS11605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS11635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOBS_RS11640	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS11645	COG2032	superoxide dismutase activity
GOBS_RS11655	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS11670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOBS_RS11675	COG2124	cytochrome p450
GOBS_RS11685	COG0589	response to stress
GOBS_RS11705	COG0583	DNA-binding transcription factor activity
GOBS_RS11710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GOBS_RS11750	COG0579	oxidoreductase
GOBS_RS11755	COG0277	FAD linked oxidase domain protein
GOBS_RS11770	COG2909	trisaccharide binding
GOBS_RS11805	COG2124	cytochrome p450
GOBS_RS11820	COG1278	Cold shock
GOBS_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS11855	COG0439	Biotin carboxylase
GOBS_RS11860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GOBS_RS11875	COG4941	Belongs to the sigma-70 factor family
GOBS_RS11890	COG1970	mechanosensitive ion channel activity
GOBS_RS11910	COG1414	Transcriptional regulator
GOBS_RS11915	COG0800	Aldolase
GOBS_RS11940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GOBS_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS11950	COG0129	dihydroxy-acid dehydratase activity
GOBS_RS11960	COG0179	Fumarylacetoacetate (FAA) hydrolase
GOBS_RS11965	COG1063	alcohol dehydrogenase
GOBS_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS11980	COG3279	Response regulator of the LytR AlgR family
GOBS_RS11985	COG1063	alcohol dehydrogenase
GOBS_RS12000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GOBS_RS12015	COG0535	radical SAM domain protein
GOBS_RS12035	COG0531	amino acid
GOBS_RS12040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOBS_RS12045	COG0596	Alpha beta hydrolase
GOBS_RS12050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GOBS_RS12090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GOBS_RS12105	COG0584	glycerophosphoryl diester phosphodiesterase
GOBS_RS12110	COG1228	amidohydrolase
GOBS_RS12125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GOBS_RS12130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GOBS_RS12135	COG1116	anion transmembrane transporter activity
GOBS_RS12140	COG1595	DNA-templated transcription, initiation
GOBS_RS12220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS12340	COG1024	Enoyl-CoA hydratase
GOBS_RS12355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GOBS_RS12360	COG1940	carbohydrate kinase activity
GOBS_RS12365	COG0477	Major facilitator Superfamily
GOBS_RS12405	COG0582	viral genome integration into host DNA
GOBS_RS12470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GOBS_RS12495	COG1355	regulation of microtubule-based process
GOBS_RS12505	COG2814	Major facilitator Superfamily
GOBS_RS12520	COG3237	CsbD-like
GOBS_RS12535	COG0277	FAD linked oxidase domain protein
GOBS_RS12540	COG0698	ribose 5-phosphate isomerase
GOBS_RS12550	COG2337	Toxic component of a toxin-antitoxin (TA) module
GOBS_RS12585	COG2072	flavoprotein involved in K transport
GOBS_RS12620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOBS_RS12665	COG3246	L-lysine catabolic process to acetate
GOBS_RS12680	COG3547	Transposase (IS116 IS110 IS902 family)
GOBS_RS12720	COG2902	Dehydrogenase
GOBS_RS12730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GOBS_RS12735	COG1366	Belongs to the anti-sigma-factor antagonist family
GOBS_RS12815	COG0596	Alpha beta hydrolase
GOBS_RS12860	COG4935	Belongs to the peptidase S8 family
GOBS_RS12860	COG1404	Belongs to the peptidase S8 family
GOBS_RS12870	COG3328	transposase activity
GOBS_RS12890	COG1172	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS12900	COG1129	ABC transporter
GOBS_RS12905	COG1879	ABC-type sugar transport system periplasmic component
GOBS_RS12915	COG1609	Transcriptional regulator
GOBS_RS12925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOBS_RS12930	COG0583	DNA-binding transcription factor activity
GOBS_RS12935	COG1794	racemase activity, acting on amino acids and derivatives
GOBS_RS12940	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS12980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GOBS_RS12985	COG0667	Aldo Keto reductase
GOBS_RS12990	COG1968	undecaprenyl-diphosphatase activity
GOBS_RS13000	COG1846	Transcriptional regulator
GOBS_RS13030	COG0215	cysteine-tRNA ligase activity
GOBS_RS13035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GOBS_RS13060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOBS_RS13080	COG1222	aaa ATPase
GOBS_RS13085	COG4122	O-methyltransferase activity
GOBS_RS13100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GOBS_RS13105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GOBS_RS13110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GOBS_RS13125	COG2378	regulation of single-species biofilm formation
GOBS_RS13135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GOBS_RS13140	COG0805	protein transport
GOBS_RS13160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GOBS_RS13170	COG1522	sequence-specific DNA binding
GOBS_RS13185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS13195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GOBS_RS13200	COG1228	amidohydrolase
GOBS_RS13210	COG0463	Glycosyl transferase, family 2
GOBS_RS13225	COG1435	thymidine kinase activity
GOBS_RS13295	COG1072	(Pantothenic acid kinase))
GOBS_RS13300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GOBS_RS13300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GOBS_RS13320	COG1716	ATPase activity
GOBS_RS13325	COG0509	glycine decarboxylation via glycine cleavage system
GOBS_RS13365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GOBS_RS13370	COG4988	ABC transporter
GOBS_RS13375	COG1294	oxidase, subunit
GOBS_RS13380	COG1271	oxidase subunit
GOBS_RS13395	COG2188	Transcriptional regulator
GOBS_RS13400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GOBS_RS13415	COG3962	Belongs to the TPP enzyme family
GOBS_RS13425	COG0673	inositol 2-dehydrogenase activity
GOBS_RS13430	COG1082	Xylose isomerase domain protein TIM barrel
GOBS_RS13445	COG1609	Transcriptional regulator
GOBS_RS13450	COG1349	DNA-binding transcription factor activity
GOBS_RS13465	COG2814	Major facilitator Superfamily
GOBS_RS13480	COG1942	4-Oxalocrotonate Tautomerase
GOBS_RS13490	COG0673	inositol 2-dehydrogenase activity
GOBS_RS13495	COG1609	Transcriptional regulator
GOBS_RS13515	COG1082	Xylose isomerase domain protein TIM barrel
GOBS_RS13525	COG0673	inositol 2-dehydrogenase activity
GOBS_RS13535	COG0656	L-ascorbic acid biosynthetic process
GOBS_RS13560	COG0673	inositol 2-dehydrogenase activity
GOBS_RS13620	COG0246	Mannitol dehydrogenase
GOBS_RS13640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GOBS_RS13655	COG3842	ATPase activity
GOBS_RS13660	COG1063	alcohol dehydrogenase
GOBS_RS13665	COG0395	ABC-type sugar transport system, permease component
GOBS_RS13670	COG1175	transmembrane transport
GOBS_RS13705	COG0589	response to stress
GOBS_RS13710	COG1846	Transcriptional regulator
GOBS_RS13725	COG3655	Transcriptional regulator
GOBS_RS13735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GOBS_RS13740	COG1522	sequence-specific DNA binding
GOBS_RS13745	COG1464	Belongs to the NlpA lipoprotein family
GOBS_RS13750	COG2011	ABC-type metal ion transport system permease component
GOBS_RS13755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GOBS_RS13765	COG0642	Histidine kinase
GOBS_RS13765	COG3850	Histidine kinase
GOBS_RS13770	COG0745	RESPONSE REGULATOR receiver
GOBS_RS13795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GOBS_RS13805	COG0477	Major facilitator Superfamily
GOBS_RS13840	COG1607	acyl-coa hydrolase
GOBS_RS13845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GOBS_RS13860	COG0726	polysaccharide deacetylase
GOBS_RS13890	COG4266	Belongs to the allantoicase family
GOBS_RS13895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOBS_RS13900	COG3622	Belongs to the hyi family
GOBS_RS13915	COG1802	Transcriptional regulator
GOBS_RS13925	COG2610	gluconate transmembrane transporter activity
GOBS_RS13930	COG4948	Mandelate Racemase Muconate Lactonizing
GOBS_RS13935	COG1902	pentaerythritol trinitrate reductase activity
GOBS_RS13935	COG0446	pyridine nucleotide-disulphide oxidoreductase
GOBS_RS13945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GOBS_RS13960	COG1414	Transcriptional regulator
GOBS_RS13975	COG1090	epimerase
GOBS_RS13980	COG1595	DNA-templated transcription, initiation
GOBS_RS14005	COG2197	response regulator
GOBS_RS14045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GOBS_RS14055	COG1760	l-serine dehydratase
GOBS_RS14065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GOBS_RS14070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GOBS_RS14105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GOBS_RS14115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOBS_RS14125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOBS_RS14130	COG1414	Transcriptional regulator
GOBS_RS14140	COG1760	l-serine dehydratase
GOBS_RS14175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GOBS_RS14195	COG3328	transposase activity
GOBS_RS14200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GOBS_RS14220	COG1414	Transcriptional regulator
GOBS_RS14225	COG2146	nitrite reductase [NAD(P)H] activity
GOBS_RS14230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GOBS_RS14255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GOBS_RS14265	COG1131	(ABC) transporter
GOBS_RS14295	COG2111	Na H antiporter
GOBS_RS14295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GOBS_RS14300	COG1006	Multisubunit Na H antiporter MnhC subunit
GOBS_RS14305	COG0651	ATP synthesis coupled electron transport
GOBS_RS14310	COG1863	multisubunit Na H antiporter MnhE subunit
GOBS_RS14315	COG2212	antiporter activity
GOBS_RS14320	COG1320	monovalent cation:proton antiporter activity
GOBS_RS14325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GOBS_RS14330	COG3387	PFAM Glycoside hydrolase 15-related
GOBS_RS14345	COG2261	transglycosylase associated protein
GOBS_RS14360	COG2197	response regulator
GOBS_RS14385	COG3263	regulation of cellular component size
GOBS_RS14400	COG1253	flavin adenine dinucleotide binding
GOBS_RS14445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GOBS_RS14450	COG0471	metal ion transport
GOBS_RS14455	COG0281	malic enzyme
GOBS_RS14460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOBS_RS14465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOBS_RS14470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GOBS_RS14480	COG4565	transcriptional regulatory protein
GOBS_RS14485	COG2814	Major facilitator Superfamily
GOBS_RS14540	COG1160	GTP binding
GOBS_RS14545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GOBS_RS14550	COG4401	Chorismate mutase type I
GOBS_RS14555	COG1070	Carbohydrate kinase
GOBS_RS14560	COG2115	Belongs to the xylose isomerase family
GOBS_RS14585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GOBS_RS14590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GOBS_RS14610	COG0686	Belongs to the AlaDH PNT family
GOBS_RS14635	COG0494	nUDIX hydrolase
GOBS_RS14640	COG0504	CTP synthase activity
GOBS_RS14650	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS14685	COG0497	DNA recombination
GOBS_RS14690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GOBS_RS14710	COG0647	UMP catabolic process
GOBS_RS14755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GOBS_RS14760	COG2094	Belongs to the DNA glycosylase MPG family
GOBS_RS14765	COG0165	Argininosuccinate lyase
GOBS_RS14770	COG1438	arginine binding
GOBS_RS14775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GOBS_RS14780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GOBS_RS14785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GOBS_RS14790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GOBS_RS14795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GOBS_RS14815	COG0072	phenylalanine-tRNA ligase activity
GOBS_RS14815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOBS_RS14820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GOBS_RS14830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GOBS_RS14835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GOBS_RS14840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GOBS_RS14845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GOBS_RS14870	COG2223	nitrite transmembrane transporter activity
GOBS_RS14880	COG1595	DNA-templated transcription, initiation
GOBS_RS14915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GOBS_RS14920	COG0243	molybdopterin cofactor binding
GOBS_RS14940	COG4941	Belongs to the sigma-70 factor family
GOBS_RS14945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GOBS_RS14955	COG2040	homocysteine
GOBS_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS14975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GOBS_RS15005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GOBS_RS15025	COG2423	ornithine cyclodeaminase activity
GOBS_RS15055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS15060	COG5001	Diguanylate cyclase
GOBS_RS15060	COG3300	MHYT domain
GOBS_RS15075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GOBS_RS15090	COG3181	Tripartite tricarboxylate transporter family receptor
GOBS_RS15105	COG0583	DNA-binding transcription factor activity
GOBS_RS15150	COG0589	response to stress
GOBS_RS15165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GOBS_RS15190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GOBS_RS15195	COG0140	phosphoribosyl-ATP diphosphatase activity
GOBS_RS15200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GOBS_RS15205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GOBS_RS15205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GOBS_RS15230	COG2197	response regulator
GOBS_RS15245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GOBS_RS15250	COG0242	peptide deformylase activity
GOBS_RS15270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GOBS_RS15280	COG1758	RNA polymerase activity
GOBS_RS15285	COG0194	GDP metabolic process
GOBS_RS15300	COG0284	orotidine-5'-phosphate decarboxylase activity
GOBS_RS15305	COG0167	dihydroorotate dehydrogenase activity
GOBS_RS15315	COG0505	Belongs to the CarA family
GOBS_RS15320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOBS_RS15325	COG0540	Belongs to the ATCase OTCase family
GOBS_RS15330	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GOBS_RS15380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GOBS_RS15385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GOBS_RS15390	COG0006	proline dipeptidase activity
GOBS_RS15395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GOBS_RS15400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GOBS_RS15405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GOBS_RS15410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GOBS_RS15420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GOBS_RS15435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GOBS_RS15455	COG0667	Aldo Keto reductase
GOBS_RS15465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GOBS_RS15470	COG0667	Aldo Keto reductase
GOBS_RS15475	COG0124	histidyl-tRNA synthetase
GOBS_RS15485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GOBS_RS15490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GOBS_RS15500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GOBS_RS15505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOBS_RS15510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GOBS_RS15515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GOBS_RS15520	COG1862	Preprotein translocase
GOBS_RS15525	COG2255	four-way junction helicase activity
GOBS_RS15530	COG0632	four-way junction helicase activity
GOBS_RS15535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GOBS_RS15540	COG0217	transcriptional regulatory protein
GOBS_RS15545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GOBS_RS15565	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS15570	COG1560	Kdo2-lipid A biosynthetic process
GOBS_RS15575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GOBS_RS15585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GOBS_RS15645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GOBS_RS15645	COG0237	dephospho-CoA kinase activity
GOBS_RS15660	COG2226	methyltransferase
GOBS_RS15675	COG2050	protein possibly involved in aromatic compounds catabolism
GOBS_RS15685	COG0559	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS15690	COG1079	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS15725	COG1946	Acyl-CoA thioesterase
GOBS_RS15740	COG0070	glutamate synthase
GOBS_RS15740	COG0069	glutamate synthase activity
GOBS_RS15740	COG0067	glutamate synthase
GOBS_RS15745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GOBS_RS15755	COG0133	tryptophan synthase activity
GOBS_RS15760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOBS_RS15775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GOBS_RS15780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GOBS_RS15815	COG1132	(ABC) transporter
GOBS_RS15830	COG0107	imidazoleglycerol-phosphate synthase activity
GOBS_RS15840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GOBS_RS15865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GOBS_RS15875	COG0131	Imidazoleglycerol-phosphate dehydratase
GOBS_RS15880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GOBS_RS15885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GOBS_RS15900	COG0587	DNA-directed DNA polymerase activity
GOBS_RS15905	COG0456	acetyltransferase
GOBS_RS15920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GOBS_RS15925	COG0579	oxidoreductase
GOBS_RS15930	COG3263	regulation of cellular component size
GOBS_RS15935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GOBS_RS15955	COG1799	cell septum assembly
GOBS_RS15970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GOBS_RS15980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GOBS_RS15985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GOBS_RS15990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GOBS_RS16000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GOBS_RS16010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GOBS_RS16015	COG0768	penicillin binding
GOBS_RS16025	COG0275	rRNA processing
GOBS_RS16030	COG2001	Belongs to the MraZ family
GOBS_RS16035	COG0714	Associated with various cellular activities
GOBS_RS16060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GOBS_RS16100	COG0587	DNA-directed DNA polymerase activity
GOBS_RS16135	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS16140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GOBS_RS16145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GOBS_RS16160	COG0640	Transcriptional regulator
GOBS_RS16190	COG2354	Protein conserved in bacteria
GOBS_RS16210	COG0142	geranyltranstransferase activity
GOBS_RS16235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GOBS_RS16240	COG2815	serine threonine protein kinase
GOBS_RS16240	COG0515	serine threonine protein kinase
GOBS_RS16245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GOBS_RS16255	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GOBS_RS16270	COG0840	transmembrane signaling receptor activity
GOBS_RS16295	COG1940	carbohydrate kinase activity
GOBS_RS16305	COG0003	Pfam Anion-transporting ATPase
GOBS_RS16320	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS16325	COG0501	Belongs to the peptidase M48B family
GOBS_RS16340	COG1876	peptidase activity
GOBS_RS16355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GOBS_RS16365	COG1845	cytochrome c oxidase, subunit III
GOBS_RS16370	COG2010	Cytochrome c
GOBS_RS16380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GOBS_RS16390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GOBS_RS16420	COG0667	Aldo Keto reductase
GOBS_RS16445	COG1295	ribonuclease BN
GOBS_RS16450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GOBS_RS16455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GOBS_RS16465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOBS_RS16470	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOBS_RS16480	COG0515	serine threonine protein kinase
GOBS_RS16485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GOBS_RS16495	COG0321	lipoyl(octanoyl) transferase activity
GOBS_RS16500	COG0495	leucyl-tRNA aminoacylation
GOBS_RS16510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GOBS_RS16525	COG0174	glutamine synthetase
GOBS_RS16530	COG0492	ferredoxin-NADP+ reductase activity
GOBS_RS16550	COG1966	Carbon starvation protein
GOBS_RS16555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GOBS_RS16585	COG0235	Class ii aldolase
GOBS_RS16590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GOBS_RS16600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GOBS_RS16620	COG0737	Belongs to the 5'-nucleotidase family
GOBS_RS16620	COG4085	toxin activity
GOBS_RS16620	COG1525	nuclease
GOBS_RS16635	COG0840	transmembrane signaling receptor activity
GOBS_RS16645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GOBS_RS16655	COG0174	glutamine synthetase
GOBS_RS16660	COG0330	HflC and HflK could
GOBS_RS16670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GOBS_RS16670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GOBS_RS16675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GOBS_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS16735	COG0596	Alpha beta hydrolase
GOBS_RS16780	COG2894	cell division
GOBS_RS16805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GOBS_RS16820	COG2223	nitrite transmembrane transporter activity
GOBS_RS16825	COG2814	Major facilitator Superfamily
GOBS_RS16830	COG0492	ferredoxin-NADP+ reductase activity
GOBS_RS16835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GOBS_RS16865	COG2610	gluconate transmembrane transporter activity
GOBS_RS16905	COG0582	viral genome integration into host DNA
GOBS_RS16910	COG2319	Wd-40 repeat
GOBS_RS16910	COG4249	Peptidase C14 caspase catalytic subunit p20
GOBS_RS16940	COG0730	response to heat
GOBS_RS16970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GOBS_RS17000	COG0596	Alpha beta hydrolase
GOBS_RS17005	COG2226	methyltransferase
GOBS_RS17005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS17005	COG0596	Alpha beta hydrolase
GOBS_RS17115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GOBS_RS17135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GOBS_RS17145	COG1473	amidohydrolase
GOBS_RS17150	COG1741	Belongs to the pirin family
GOBS_RS17155	COG0671	phosphoesterase, PA-phosphatase related
GOBS_RS17170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GOBS_RS17175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOBS_RS17205	COG4942	peptidase
GOBS_RS17220	COG4974	Belongs to the 'phage' integrase family
GOBS_RS17235	COG1122	ATPase activity
GOBS_RS17245	COG0464	growth
GOBS_RS17265	COG3547	Transposase (IS116 IS110 IS902 family)
GOBS_RS17290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOBS_RS17295	COG0667	Aldo Keto reductase
GOBS_RS17300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GOBS_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS17315	COG3321	synthase
GOBS_RS17315	COG0604	alcohol dehydrogenase
GOBS_RS17340	COG1131	(ABC) transporter
GOBS_RS17350	COG0604	alcohol dehydrogenase
GOBS_RS17380	COG2720	vancomycin resistance protein
GOBS_RS17395	COG2313	pseudouridylate synthase activity
GOBS_RS17420	COG1490	D-aminoacyl-tRNA deacylase activity
GOBS_RS17435	COG0123	including yeast histone deacetylase and acetoin utilization protein
GOBS_RS17445	COG1506	peptidase
GOBS_RS17445	COG0823	Involved in the tonB-independent uptake of proteins
GOBS_RS17590	COG1937	Protein conserved in bacteria
GOBS_RS17615	COG0596	Alpha beta hydrolase
GOBS_RS17630	COG1271	oxidase subunit
GOBS_RS17635	COG1294	oxidase, subunit
GOBS_RS17640	COG4988	ABC transporter
GOBS_RS17655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GOBS_RS17660	COG0473	3-isopropylmalate dehydrogenase activity
GOBS_RS17665	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS17680	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GOBS_RS17695	COG4565	transcriptional regulatory protein
GOBS_RS17700	COG3290	protein histidine kinase activity
GOBS_RS17730	COG4302	ethanolamine ammonia-lyase activity
GOBS_RS17740	COG0531	amino acid
GOBS_RS17805	COG0463	Glycosyl transferase, family 2
GOBS_RS17820	COG3842	ATPase activity
GOBS_RS17845	COG4941	Belongs to the sigma-70 factor family
GOBS_RS17895	COG1024	Enoyl-CoA hydratase
GOBS_RS17900	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GOBS_RS17900	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GOBS_RS17930	COG4251	negative regulation of phosphorylation
GOBS_RS17945	COG0515	serine threonine protein kinase
GOBS_RS17950	COG1690	Belongs to the RtcB family
GOBS_RS17965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS17980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GOBS_RS18020	COG0492	ferredoxin-NADP+ reductase activity
GOBS_RS18040	COG1487	ribonuclease activity
GOBS_RS18185	COG3654	unkown
GOBS_RS18200	COG1470	cell adhesion involved in biofilm formation
GOBS_RS18235	COG0210	DNA helicase
GOBS_RS18240	COG1201	RNA secondary structure unwinding
GOBS_RS18270	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS18280	COG5001	Diguanylate cyclase
GOBS_RS18300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GOBS_RS18320	COG2070	2-Nitropropane dioxygenase
GOBS_RS18335	COG3177	Filamentation induced by cAMP protein fic
GOBS_RS18355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOBS_RS18385	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS18405	COG0179	Fumarylacetoacetate (FAA) hydrolase
GOBS_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS18415	COG0179	Fumarylacetoacetate (FAA) hydrolase
GOBS_RS18420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GOBS_RS18425	COG0579	oxidoreductase
GOBS_RS18450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GOBS_RS18480	COG2358	TRAP transporter, solute receptor (TAXI family
GOBS_RS18490	COG4221	oxidoreductase activity
GOBS_RS18515	COG0435	Glutathione S-transferase
GOBS_RS18540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GOBS_RS18545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GOBS_RS18565	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS18580	COG0596	Alpha beta hydrolase
GOBS_RS18600	COG2124	cytochrome p450
GOBS_RS18640	COG0183	Belongs to the thiolase family
GOBS_RS18660	COG0559	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS18695	COG2326	polyphosphate kinase activity
GOBS_RS18725	COG0513	Belongs to the DEAD box helicase family
GOBS_RS18745	COG0673	inositol 2-dehydrogenase activity
GOBS_RS18750	COG1879	ABC-type sugar transport system periplasmic component
GOBS_RS18755	COG1172	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS18760	COG1129	ABC transporter
GOBS_RS18765	COG1940	carbohydrate kinase activity
GOBS_RS18775	COG1252	NADH dehydrogenase
GOBS_RS18805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GOBS_RS18820	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS18840	COG2318	DinB family
GOBS_RS18855	COG0667	Aldo Keto reductase
GOBS_RS18870	COG0738	Major facilitator superfamily
GOBS_RS18905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GOBS_RS18910	COG0456	acetyltransferase
GOBS_RS18930	COG2814	Major facilitator Superfamily
GOBS_RS18975	COG2072	flavoprotein involved in K transport
GOBS_RS18990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GOBS_RS18995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GOBS_RS19010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GOBS_RS19025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GOBS_RS19040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GOBS_RS19050	COG1196	nuclear chromosome segregation
GOBS_RS19055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GOBS_RS19060	COG1126	abc transporter atp-binding protein
GOBS_RS19065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GOBS_RS19070	COG0765	amino acid transport
GOBS_RS19075	COG0765	amino acid transport
GOBS_RS19095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GOBS_RS19105	COG2814	Major facilitator Superfamily
GOBS_RS19115	COG1201	RNA secondary structure unwinding
GOBS_RS19125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GOBS_RS19130	COG1842	Phage shock protein A
GOBS_RS19180	COG1396	sequence-specific DNA binding
GOBS_RS19190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GOBS_RS19195	COG1674	ftsk spoiiie
GOBS_RS19215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GOBS_RS19225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GOBS_RS19235	COG3214	Protein conserved in bacteria
GOBS_RS19265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GOBS_RS19275	COG0612	Peptidase, M16
GOBS_RS19280	COG1185	polyribonucleotide nucleotidyltransferase activity
GOBS_RS19285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GOBS_RS19295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GOBS_RS19305	COG0546	phosphoglycolate phosphatase activity
GOBS_RS19310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GOBS_RS19320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GOBS_RS19330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GOBS_RS19340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GOBS_RS19350	COG0779	Required for maturation of 30S ribosomal subunits
GOBS_RS19375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GOBS_RS19380	COG0750	zinc metalloprotease
GOBS_RS19410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GOBS_RS19435	COG2326	polyphosphate kinase activity
GOBS_RS19450	COG0233	cytoplasmic translational termination
GOBS_RS19455	COG0528	UMP kinase activity
GOBS_RS19465	COG0052	Belongs to the universal ribosomal protein uS2 family
GOBS_RS19480	COG1191	sigma factor activity
GOBS_RS19485	COG4974	Belongs to the 'phage' integrase family
GOBS_RS19500	COG0792	nuclease activity
GOBS_RS19510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GOBS_RS19515	COG2197	response regulator
GOBS_RS19520	COG0681	Belongs to the peptidase S26 family
GOBS_RS19525	COG0335	large ribosomal subunit rRNA binding
GOBS_RS19535	COG0336	Belongs to the RNA methyltransferase TrmD family
GOBS_RS19540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GOBS_RS19550	COG0228	four-way junction DNA binding
GOBS_RS19555	COG0442	prolyl-tRNA aminoacylation
GOBS_RS19575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GOBS_RS19600	COG1122	ATPase activity
GOBS_RS19635	COG1196	nuclear chromosome segregation
GOBS_RS19645	COG1254	Belongs to the acylphosphatase family
GOBS_RS19650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GOBS_RS19655	COG0571	ribonuclease III activity
GOBS_RS19660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GOBS_RS19665	COG1399	metal-binding, possibly nucleic acid-binding protein
GOBS_RS19675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GOBS_RS19680	COG0742	ribosomal rna small subunit methyltransferase
GOBS_RS19690	COG1461	Dihydroxyacetone kinase
GOBS_RS19695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GOBS_RS19735	COG1183	phosphatidylcholine synthase activity
GOBS_RS19740	COG0626	cystathionine gamma-synthase activity
GOBS_RS19745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GOBS_RS19755	COG1920	GTP binding
GOBS_RS19760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GOBS_RS19765	COG0494	nUDIX hydrolase
GOBS_RS19765	COG0406	alpha-ribazole phosphatase activity
GOBS_RS19770	COG0066	3-isopropylmalate dehydratase activity
GOBS_RS19775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GOBS_RS19790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GOBS_RS19825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GOBS_RS19830	COG0179	Fumarylacetoacetate (FAA) hydrolase
GOBS_RS19845	COG4585	Histidine kinase
GOBS_RS19850	COG2197	response regulator
GOBS_RS19860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GOBS_RS19865	COG0473	3-isopropylmalate dehydrogenase activity
GOBS_RS19885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GOBS_RS19890	COG0440	acetolactate synthase activity
GOBS_RS19905	COG4251	negative regulation of phosphorylation
GOBS_RS19905	COG3706	GGDEF domain
GOBS_RS19905	COG2203	Gaf domain
GOBS_RS19905	COG5001	Diguanylate cyclase
GOBS_RS19910	COG0129	dihydroxy-acid dehydratase activity
GOBS_RS19935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GOBS_RS19945	COG0154	amidase activity
GOBS_RS19950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GOBS_RS19960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GOBS_RS19970	COG0482	sulfurtransferase activity
GOBS_RS19985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GOBS_RS19990	COG2086	electron transfer activity
GOBS_RS19995	COG1024	Enoyl-CoA hydratase
GOBS_RS20010	COG1119	ATPase activity
GOBS_RS20025	COG0058	SHG alpha-glucan phosphorylase activity
GOBS_RS20030	COG0366	Alpha amylase catalytic
GOBS_RS20045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GOBS_RS20075	COG1703	isobutyryl-CoA mutase activity
GOBS_RS20080	COG0183	Belongs to the thiolase family
GOBS_RS20085	COG2267	carboxylic ester hydrolase activity
GOBS_RS20120	COG1250	3-hydroxyacyl-CoA dehydrogenase
GOBS_RS20125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GOBS_RS20135	COG1823	symporter activity
GOBS_RS20150	COG1024	Enoyl-CoA hydratase
GOBS_RS20160	COG0673	inositol 2-dehydrogenase activity
GOBS_RS20165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GOBS_RS20165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GOBS_RS20175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GOBS_RS20180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GOBS_RS20195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GOBS_RS20205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GOBS_RS20215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GOBS_RS20220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GOBS_RS20225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GOBS_RS20230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GOBS_RS20235	COG0356	it plays a direct role in the translocation of protons across the membrane
GOBS_RS20250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GOBS_RS20255	COG0009	L-threonylcarbamoyladenylate synthase
GOBS_RS20260	COG2890	protein-(glutamine-N5) methyltransferase activity
GOBS_RS20265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GOBS_RS20270	COG0254	rRNA binding
GOBS_RS20280	COG0083	homoserine kinase activity
GOBS_RS20285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GOBS_RS20290	COG0460	homoserine dehydrogenase
GOBS_RS20295	COG0019	diaminopimelate decarboxylase activity
GOBS_RS20300	COG0018	arginyl-trna synthetase
GOBS_RS20320	COG0702	epimerase
GOBS_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS20330	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS20340	COG3243	poly(R)-hydroxyalkanoic acid synthase
GOBS_RS20355	COG0488	(ABC) transporter
GOBS_RS20360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GOBS_RS20370	COG1131	(ABC) transporter
GOBS_RS20385	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOBS_RS20385	COG0567	Dehydrogenase, E1 component
GOBS_RS20425	COG0688	phosphatidylethanolamine metabolic process
GOBS_RS20430	COG1183	phosphatidylcholine synthase activity
GOBS_RS20450	COG1597	lipid kinase activity
GOBS_RS20470	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GOBS_RS20475	COG0439	Biotin carboxylase
GOBS_RS20485	COG1595	DNA-templated transcription, initiation
GOBS_RS20490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GOBS_RS20500	COG2135	peptidase activity
GOBS_RS20505	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS20510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GOBS_RS20515	COG1162	GTPase activity
GOBS_RS20530	COG0483	inositol monophosphate 1-phosphatase activity
GOBS_RS20535	COG1070	Carbohydrate kinase
GOBS_RS20540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GOBS_RS20540	COG3608	succinylglutamate desuccinylase aspartoacylase
GOBS_RS20550	COG0667	Aldo Keto reductase
GOBS_RS20590	COG0346	lactoylglutathione lyase activity
GOBS_RS20605	COG4176	ABC-type proline glycine betaine transport system permease component
GOBS_RS20610	COG3448	diguanylate cyclase activity
GOBS_RS20610	COG4175	Glycine betaine
GOBS_RS20620	COG2175	clavaminate synthase activity
GOBS_RS20645	COG1615	UPF0182 protein
GOBS_RS20650	COG3480	Lon protease (S16) C-terminal proteolytic domain
GOBS_RS20710	COG0612	Peptidase, M16
GOBS_RS20735	COG0596	Alpha beta hydrolase
GOBS_RS20740	COG0210	DNA helicase
GOBS_RS20745	COG0210	DNA helicase
GOBS_RS20775	COG0596	Alpha beta hydrolase
GOBS_RS20795	COG0513	Belongs to the DEAD box helicase family
GOBS_RS20805	COG0596	Alpha beta hydrolase
GOBS_RS20820	COG0613	PHP domain protein
GOBS_RS20905	COG0653	protein targeting
GOBS_RS20925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GOBS_RS20935	COG5401	PFAM Sporulation and spore germination
GOBS_RS20940	COG5000	phosphorelay sensor kinase activity
GOBS_RS20940	COG5002	protein histidine kinase activity
GOBS_RS20945	COG0745	RESPONSE REGULATOR receiver
GOBS_RS20950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GOBS_RS20970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GOBS_RS20975	COG0673	inositol 2-dehydrogenase activity
GOBS_RS21005	COG2835	tetraacyldisaccharide 4'-kinase activity
GOBS_RS21040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GOBS_RS21080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GOBS_RS21125	COG1216	Glycosyl transferase, family 2
GOBS_RS21130	COG1216	Glycosyl transferase, family 2
GOBS_RS21145	COG1216	Glycosyl transferase, family 2
GOBS_RS21175	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GOBS_RS21175	COG5479	isomerase activity
GOBS_RS21200	COG2089	acid synthase
GOBS_RS21205	COG1316	TRANSCRIPTIONal
GOBS_RS21245	COG0640	Transcriptional regulator
GOBS_RS21285	COG0789	Transcriptional regulator
GOBS_RS21290	COG0659	secondary active sulfate transmembrane transporter activity
GOBS_RS21320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GOBS_RS21320	COG2755	lipolytic protein G-D-S-L family
GOBS_RS21335	COG0419	ATPase involved in DNA repair
GOBS_RS21340	COG0420	3'-5' exonuclease activity
GOBS_RS21350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GOBS_RS21350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GOBS_RS21355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GOBS_RS21365	COG0424	maF-like protein
GOBS_RS21370	COG4770	biotin carboxylase activity
GOBS_RS21410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS21410	COG1473	amidohydrolase
GOBS_RS21415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS21430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOBS_RS21435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GOBS_RS21440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GOBS_RS21440	COG2755	lipolytic protein G-D-S-L family
GOBS_RS21460	COG0673	inositol 2-dehydrogenase activity
GOBS_RS21480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GOBS_RS21485	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
GOBS_RS21505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GOBS_RS21530	COG1079	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS21535	COG4603	Belongs to the binding-protein-dependent transport system permease family
GOBS_RS21540	COG3845	ABC transporter
GOBS_RS21545	COG1744	ABC transporter substrate-binding protein PnrA-like
GOBS_RS21560	COG0180	Tryptophanyl-tRNA synthetase
GOBS_RS21565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GOBS_RS21575	COG1253	flavin adenine dinucleotide binding
GOBS_RS21580	COG2340	Cysteine-rich secretory protein family
GOBS_RS21590	COG0538	isocitrate dehydrogenase activity
GOBS_RS21605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GOBS_RS21620	COG0138	bifunctional purine biosynthesis protein purh
GOBS_RS21645	COG0045	succinate-CoA ligase (ADP-forming) activity
GOBS_RS21665	COG0739	heme binding
GOBS_RS21710	COG2197	response regulator
GOBS_RS21730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GOBS_RS21750	COG0519	Catalyzes the synthesis of GMP from XMP
GOBS_RS21750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GOBS_RS21770	COG2197	response regulator
GOBS_RS21790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GOBS_RS21800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GOBS_RS21815	COG0494	nUDIX hydrolase
GOBS_RS21820	COG0802	atpase or kinase
GOBS_RS21825	COG1573	uracil-dna glycosylase
GOBS_RS21835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GOBS_RS21845	COG0736	holo-[acyl-carrier-protein] synthase activity
GOBS_RS21850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GOBS_RS21855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GOBS_RS21860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GOBS_RS21865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GOBS_RS21880	COG0315	cyclic pyranopterin monophosphate synthase activity
GOBS_RS21885	COG0521	Mo-molybdopterin cofactor biosynthetic process
GOBS_RS21890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GOBS_RS21905	COG0101	tRNA pseudouridine synthase activity
GOBS_RS21915	COG0203	ribosomal protein L17
GOBS_RS21920	COG0202	RNA polymerase activity
GOBS_RS21925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GOBS_RS21930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GOBS_RS21935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GOBS_RS21940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GOBS_RS21945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GOBS_RS21955	COG0563	adenylate kinase activity
GOBS_RS21965	COG0200	Binds to the 23S rRNA
GOBS_RS21970	COG1841	ribosomal large subunit assembly
GOBS_RS21975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GOBS_RS21980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GOBS_RS21985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GOBS_RS21990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GOBS_RS22000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GOBS_RS22005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GOBS_RS22010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GOBS_RS22015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GOBS_RS22020	COG0255	Belongs to the universal ribosomal protein uL29 family
GOBS_RS22025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GOBS_RS22030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GOBS_RS22035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GOBS_RS22040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GOBS_RS22045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GOBS_RS22050	COG0089	rRNA binding
GOBS_RS22055	COG0088	Forms part of the polypeptide exit tunnel
GOBS_RS22060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GOBS_RS22065	COG0051	transcription antitermination factor activity, RNA binding
GOBS_RS22070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GOBS_RS22075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GOBS_RS22080	COG0049	tRNA binding
GOBS_RS22085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GOBS_RS22100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOBS_RS22110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GOBS_RS22115	COG0085	RNA polymerase activity
GOBS_RS22120	COG0222	ribosome binding
GOBS_RS22130	COG0081	regulation of translation
GOBS_RS22135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GOBS_RS22155	COG0436	Aminotransferase
GOBS_RS22170	COG2030	dehydratase
GOBS_RS22175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GOBS_RS22205	COG1666	GTP binding
GOBS_RS22220	COG0501	Belongs to the peptidase M48B family
GOBS_RS22225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GOBS_RS22225	COG0674	pyruvate-flavodoxin oxidoreductase activity
GOBS_RS22230	COG1013	pyruvate-flavodoxin oxidoreductase activity
GOBS_RS22240	COG1725	Transcriptional regulator
GOBS_RS22255	COG0142	geranyltranstransferase activity
GOBS_RS22260	COG1007	ATP synthesis coupled electron transport
GOBS_RS22275	COG0713	ATP synthesis coupled electron transport
GOBS_RS22285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOBS_RS22290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GOBS_RS22295	COG1034	ATP synthesis coupled electron transport
GOBS_RS22310	COG0649	NAD binding
GOBS_RS22315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOBS_RS22320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOBS_RS22330	COG0644	oxidoreductase
GOBS_RS22335	COG2226	methyltransferase
GOBS_RS22345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GOBS_RS22350	COG4948	Mandelate Racemase Muconate Lactonizing
GOBS_RS22370	COG1522	sequence-specific DNA binding
GOBS_RS22385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GOBS_RS22395	COG4232	protein-disulfide reductase activity
GOBS_RS22400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOBS_RS22405	COG0406	alpha-ribazole phosphatase activity
GOBS_RS22410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GOBS_RS22420	COG0113	porphobilinogen synthase activity
GOBS_RS22425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GOBS_RS22425	COG1648	precorrin-2 dehydrogenase activity
GOBS_RS22430	COG0181	hydroxymethylbilane synthase activity
GOBS_RS22435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GOBS_RS22440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GOBS_RS22450	COG0318	PFAM AMP-dependent synthetase and ligase
GOBS_RS22490	COG0693	protein deglycase activity
GOBS_RS22515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GOBS_RS22540	COG0745	RESPONSE REGULATOR receiver
GOBS_RS22545	COG5002	protein histidine kinase activity
GOBS_RS22555	COG0588	phosphoglycerate mutase activity
GOBS_RS22565	COG0477	Major facilitator Superfamily
GOBS_RS22575	COG0297	glycogen (starch) synthase activity
GOBS_RS22585	COG0456	acetyltransferase
GOBS_RS22590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GOBS_RS22600	COG3287	FIST C domain
GOBS_RS22600	COG2200	EAL domain
GOBS_RS22600	COG2199	diguanylate cyclase activity
GOBS_RS22650	COG0354	folic acid binding
GOBS_RS22665	COG1365	unkown
GOBS_RS22670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GOBS_RS22730	COG2897	thiosulfate sulfurtransferase activity
GOBS_RS22755	COG0745	RESPONSE REGULATOR receiver
GOBS_RS22760	COG0456	acetyltransferase
GOBS_RS22775	COG0581	inorganic phosphate transmembrane transporter activity
GOBS_RS22780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GOBS_RS22805	COG2375	cellular response to nickel ion
GOBS_RS22810	COG0745	RESPONSE REGULATOR receiver
GOBS_RS22815	COG2205	protein histidine kinase activity
GOBS_RS22825	COG1218	3'(2'),5'-bisphosphate nucleotidase
GOBS_RS22830	COG0175	sulfate reduction
GOBS_RS22870	COG1643	Atp-dependent helicase
GOBS_RS22895	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS22910	COG1295	ribonuclease BN
GOBS_RS22990	COG0745	RESPONSE REGULATOR receiver
GOBS_RS22995	COG5002	protein histidine kinase activity
GOBS_RS22995	COG3850	Histidine kinase
GOBS_RS23010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GOBS_RS23030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GOBS_RS23050	COG2223	nitrite transmembrane transporter activity
GOBS_RS23065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GOBS_RS23070	COG2132	Multicopper oxidase
GOBS_RS23095	COG1115	amino acid carrier protein
GOBS_RS23115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GOBS_RS23120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GOBS_RS23125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GOBS_RS23130	COG0798	PFAM Bile acid sodium symporter
GOBS_RS23240	COG0346	lactoylglutathione lyase activity
GOBS_RS23260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOBS_RS23265	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GOBS_RS23305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GOBS_RS23320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOBS_RS23340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GOBS_RS23345	COG0047	phosphoribosylformylglycinamidine synthase activity
GOBS_RS23350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GOBS_RS23365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GOBS_RS23370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GOBS_RS23385	COG0151	Belongs to the GarS family
GOBS_RS23390	COG1162	GTPase activity
GOBS_RS23395	COG0584	glycerophosphoryl diester phosphodiesterase
GOBS_RS23440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GOBS_RS23465	COG0542	response to heat
GOBS_RS23470	COG1846	Transcriptional regulator
GOBS_RS23495	COG1414	Transcriptional regulator
GOBS_RS23500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GOBS_RS23505	COG0277	FAD linked oxidase domain protein
GOBS_RS23510	COG0277	FAD linked oxidase domain protein
GOBS_RS23515	COG0247	lactate metabolic process
GOBS_RS23520	COG1620	l-lactate permease
GOBS_RS23530	COG0789	Transcriptional regulator
GOBS_RS23535	COG0484	heat shock protein binding
GOBS_RS23540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GOBS_RS23545	COG0443	Heat shock 70 kDa protein
GOBS_RS23555	COG2181	nitrate reductase activity
GOBS_RS23555	COG0247	lactate metabolic process
GOBS_RS23560	COG2807	transmembrane transport
GOBS_RS23565	COG0717	Belongs to the dCTP deaminase family
GOBS_RS23610	COG2890	protein-(glutamine-N5) methyltransferase activity
GOBS_RS23635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOBS_RS23650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GOBS_RS23655	COG1309	transcriptional regulator
GOBS_RS23670	COG2199	diguanylate cyclase activity
GOBS_RS23670	COG2200	EAL domain
GOBS_RS23670	COG2203	Gaf domain
GOBS_RS23675	COG3300	MHYT domain
GOBS_RS23675	COG5001	Diguanylate cyclase
GOBS_RS23680	COG1960	acyl-CoA dehydrogenase activity
GOBS_RS23695	COG2197	response regulator
GOBS_RS23700	COG4585	Histidine kinase
GOBS_RS23710	COG1131	(ABC) transporter
GOBS_RS23720	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS23755	COG3447	MASE1 domain protein
GOBS_RS23755	COG5002	protein histidine kinase activity
GOBS_RS23755	COG5001	Diguanylate cyclase
GOBS_RS23760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GOBS_RS23765	COG1349	DNA-binding transcription factor activity
GOBS_RS23770	COG1105	Belongs to the carbohydrate kinase PfkB family
GOBS_RS23775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GOBS_RS23775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GOBS_RS23795	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOBS_RS23800	COG0022	dehydrogenase e1 component
GOBS_RS23810	COG1522	sequence-specific DNA binding
GOBS_RS23835	COG2409	Drug exporters of the RND superfamily
GOBS_RS23865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GOBS_RS23870	COG3973	AAA domain
GOBS_RS23895	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GOBS_RS23905	COG0640	Transcriptional regulator
GOBS_RS23920	COG2070	2-Nitropropane dioxygenase
GOBS_RS23925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GOBS_RS23940	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS23945	COG0366	Alpha amylase catalytic
GOBS_RS23975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOBS_RS23985	COG0386	Belongs to the glutathione peroxidase family
GOBS_RS23990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GOBS_RS23995	COG5006	permease, DMT superfamily
GOBS_RS24005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GOBS_RS24020	COG0668	transmembrane transport
GOBS_RS24030	COG1064	alcohol dehydrogenase
GOBS_RS24040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOBS_RS24060	COG0791	NLP P60 protein
GOBS_RS24090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GOBS_RS24105	COG0402	S-adenosylhomocysteine deaminase activity
GOBS_RS24110	COG0586	Pfam SNARE associated Golgi protein
GOBS_RS24145	COG2814	Major facilitator Superfamily
GOBS_RS24170	COG1902	pentaerythritol trinitrate reductase activity
GOBS_RS24170	COG0446	pyridine nucleotide-disulphide oxidoreductase
GOBS_RS24175	COG3012	SEC-C Motif Domain Protein
GOBS_RS24200	COG0535	radical SAM domain protein
GOBS_RS24215	COG0667	Aldo Keto reductase
GOBS_RS24220	COG2197	response regulator
GOBS_RS24255	COG0714	Associated with various cellular activities
GOBS_RS24315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GOBS_RS24375	COG0514	ATP-dependent DNA helicase (RecQ)
GOBS_RS24380	COG2192	nodulation
GOBS_RS24435	COG1063	alcohol dehydrogenase
GOBS_RS24440	COG3022	response to hydroperoxide
GOBS_RS24460	COG2902	Dehydrogenase
GOBS_RS24465	COG1950	PFAM Membrane protein of
GOBS_RS24500	COG0745	RESPONSE REGULATOR receiver
GOBS_RS24520	COG2201	protein-glutamate methylesterase activity
GOBS_RS24525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GOBS_RS24540	COG0784	Response regulator, receiver
GOBS_RS24540	COG2198	Histidine kinase
GOBS_RS24540	COG0643	Histidine kinase
GOBS_RS24565	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GOBS_RS24570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GOBS_RS24575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GOBS_RS24595	COG0367	asparagine synthase
GOBS_RS24630	COG4604	ABC transporter, ATP-binding protein
GOBS_RS24635	COG4605	iron ion homeostasis
GOBS_RS24640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GOBS_RS24645	COG4607	ABC-type enterochelin transport system periplasmic component
GOBS_RS24650	COG0667	Aldo Keto reductase
GOBS_RS24670	COG4191	Histidine kinase
GOBS_RS24670	COG0784	Response regulator, receiver
GOBS_RS24680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GOBS_RS24695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GOBS_RS24705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GOBS_RS24710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GOBS_RS24715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GOBS_RS24730	COG0778	Nitroreductase
GOBS_RS24735	COG2267	carboxylic ester hydrolase activity
GOBS_RS24750	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GOBS_RS24755	COG0352	thiamine-phosphate diphosphorylase activity
GOBS_RS24765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GOBS_RS24825	COG0359	binds to the 23S rRNA
GOBS_RS24830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GOBS_RS24835	COG0629	single-stranded DNA binding
GOBS_RS24840	COG0360	Binds together with S18 to 16S ribosomal RNA
GOBS_RS24845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GOBS_RS24855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOBS_RS24895	COG0617	tRNA 3'-terminal CCA addition
GOBS_RS24925	COG3118	belongs to the thioredoxin family
GOBS_RS24925	COG0492	ferredoxin-NADP+ reductase activity
GOBS_RS24935	COG0860	N-Acetylmuramoyl-L-alanine amidase
GOBS_RS24935	COG3409	Peptidoglycan-binding domain 1 protein
GOBS_RS24940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GOBS_RS24945	COG1181	Belongs to the D-alanine--D-alanine ligase family
GOBS_RS24955	COG1192	Involved in chromosome partitioning
GOBS_RS24960	COG0357	Ribosomal RNA small subunit methyltransferase G
GOBS_RS24970	COG0706	membrane insertase activity
GOBS_RS24975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GOBS_RS24980	COG0594	ribonuclease P activity
GOBS_RS25015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOBS_RS25045	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS25055	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS25075	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS25085	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS25095	COG1215	transferase activity, transferring glycosyl groups
GOBS_RS25110	COG3706	GGDEF domain
GOBS_RS25145	COG5000	phosphorelay sensor kinase activity
GOBS_RS25235	COG3591	Belongs to the peptidase S1B family
GOBS_RS25290	COG5002	protein histidine kinase activity
GOBS_RS25300	COG1028	Short-chain dehydrogenase reductase Sdr
GOBS_RS25315	COG3409	Peptidoglycan-binding domain 1 protein
GOBS_RS25315	COG0860	N-Acetylmuramoyl-L-alanine amidase
GOBS_RS25345	COG0584	glycerophosphoryl diester phosphodiesterase
GOBS_RS25395	COG0438	transferase activity, transferring glycosyl groups
GOBS_RS25400	COG1278	Cold shock
GOBS_RS25405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GOBS_RS25410	COG5002	protein histidine kinase activity
GOBS_RS25465	COG3030	protein affecting phage T7 exclusion by the F plasmid
GOBS_RS25470	COG0673	inositol 2-dehydrogenase activity
GOBS_RS25600	COG2319	Wd-40 repeat
GOBS_RS25600	COG4249	Peptidase C14 caspase catalytic subunit p20
GOBS_RS25610	COG5002	protein histidine kinase activity
GOBS_RS25610	COG5001	Diguanylate cyclase
GOBS_RS25610	COG3447	MASE1 domain protein
GOBS_RS25620	COG0596	Alpha beta hydrolase
GOBS_RS25645	COG1366	Belongs to the anti-sigma-factor antagonist family
GOBS_RS25695	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GOBS_RS25705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS25710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS25715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GOBS_RS25725	COG0740	serine-type endopeptidase activity
GOBS_RS25765	COG1674	ftsk spoiiie
GOBS_RS25775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GOBS_RS25775	COG5479	isomerase activity
GOBS_RS25790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GOBS_RS25790	COG5479	isomerase activity
GOBS_RS25855	COG5001	Diguanylate cyclase