locus-tag	class	description
F1729_RS00015	COG4191	Histidine kinase
F1729_RS00020	COG4191	Histidine kinase
F1729_RS00050	COG0596	Alpha beta hydrolase
F1729_RS00100	COG4112	unkown
F1729_RS00125	COG2204	response regulator
F1729_RS00135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F1729_RS00145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1729_RS00150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1729_RS00170	COG1063	alcohol dehydrogenase
F1729_RS00190	COG0006	proline dipeptidase activity
F1729_RS00195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1729_RS00220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1729_RS00260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS00290	COG3842	ATPase activity
F1729_RS00300	COG0363	glucosamine-6-phosphate deaminase activity
F1729_RS00305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1729_RS00310	COG3119	arylsulfatase activity
F1729_RS00325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS00355	COG4372	Transposase
F1729_RS00360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1729_RS00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1729_RS00375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F1729_RS00385	COG0848	biopolymer transport protein
F1729_RS00405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS00410	COG0793	Belongs to the peptidase S41A family
F1729_RS00415	COG0009	L-threonylcarbamoyladenylate synthase
F1729_RS00420	COG2205	protein histidine kinase activity
F1729_RS00420	COG3437	response regulator, receiver
F1729_RS00420	COG3850	Histidine kinase
F1729_RS00420	COG4999	Histidine kinase
F1729_RS00425	COG2201	protein-glutamate methylesterase activity
F1729_RS00430	COG0657	acetylesterase activity
F1729_RS00470	COG1459	type II secretion system
F1729_RS00485	COG0017	Asparaginyl-tRNA synthetase
F1729_RS00505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS00510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1729_RS00640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS00650	COG3119	arylsulfatase activity
F1729_RS00665	COG0500	methyltransferase
F1729_RS00670	COG0758	DNA mediated transformation
F1729_RS00690	COG2363	Small membrane protein
F1729_RS00715	COG2815	serine threonine protein kinase
F1729_RS00715	COG0515	serine threonine protein kinase
F1729_RS00735	COG0606	chelatase, subunit chli
F1729_RS00740	COG0004	ammonium transporteR
F1729_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F1729_RS00750	COG0352	thiamine-phosphate diphosphorylase activity
F1729_RS00755	COG0542	response to heat
F1729_RS00765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS00770	COG1966	Carbon starvation protein
F1729_RS00775	COG1196	nuclear chromosome segregation
F1729_RS00820	COG1162	GTPase activity
F1729_RS00845	COG1404	Belongs to the peptidase S8 family
F1729_RS00860	COG3119	arylsulfatase activity
F1729_RS00875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1729_RS00875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1729_RS00910	COG0516	GMP reductase activity
F1729_RS00910	COG0517	IMP dehydrogenase activity
F1729_RS00915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1729_RS00930	COG0688	phosphatidylethanolamine metabolic process
F1729_RS00935	COG0148	phosphopyruvate hydratase activity
F1729_RS00955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F1729_RS01010	COG1129	ABC transporter
F1729_RS01015	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1729_RS01025	COG0653	protein targeting
F1729_RS01030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F1729_RS01040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F1729_RS01080	COG0469	pyruvate kinase activity
F1729_RS01085	COG1331	Highly conserved protein containing a thioredoxin domain
F1729_RS01090	COG0714	Associated with various cellular activities
F1729_RS01095	COG1073	alpha beta
F1729_RS01100	COG0714	Associated with various cellular activities
F1729_RS01125	COG0004	ammonium transporteR
F1729_RS01135	COG2813	Specifically methylates the guanine in position
F1729_RS01140	COG1301	dicarboxylic acid transport
F1729_RS01160	COG0116	Belongs to the methyltransferase superfamily
F1729_RS01175	COG0673	inositol 2-dehydrogenase activity
F1729_RS01235	COG0076	glutamate decarboxylase activity
F1729_RS01260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1729_RS01265	COG3119	arylsulfatase activity
F1729_RS01270	COG1725	Transcriptional regulator
F1729_RS01275	COG1131	(ABC) transporter
F1729_RS01310	COG1858	cytochrome C peroxidase
F1729_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS01335	COG0861	Integral membrane protein TerC family
F1729_RS01360	COG3119	arylsulfatase activity
F1729_RS01380	COG3119	arylsulfatase activity
F1729_RS01425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1729_RS01450	COG0437	4 iron, 4 sulfur cluster binding
F1729_RS01495	COG1845	cytochrome c oxidase, subunit III
F1729_RS01520	COG1137	ATPase activity
F1729_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS01545	COG0316	Belongs to the HesB IscA family
F1729_RS01550	COG3481	metal-dependent phosphohydrolase, HD sub domain
F1729_RS01580	COG0481	GTPase activity
F1729_RS01585	COG1940	carbohydrate kinase activity
F1729_RS01590	COG3119	arylsulfatase activity
F1729_RS01600	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1729_RS01615	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1729_RS01620	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1729_RS01630	COG1477	protein flavinylation
F1729_RS01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1729_RS01655	COG0577	efflux transmembrane transporter activity
F1729_RS01655	COG1136	(ABC) transporter
F1729_RS01730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1729_RS01755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1729_RS01760	COG0081	regulation of translation
F1729_RS01765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1729_RS01770	COG0222	ribosome binding
F1729_RS01775	COG0085	RNA polymerase activity
F1729_RS01780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1729_RS01785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1729_RS01790	COG0049	tRNA binding
F1729_RS01795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1729_RS01800	COG0051	transcription antitermination factor activity, RNA binding
F1729_RS01805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1729_RS01810	COG0088	Forms part of the polypeptide exit tunnel
F1729_RS01815	COG0089	rRNA binding
F1729_RS01820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1729_RS01825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1729_RS01830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1729_RS01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1729_RS01840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F1729_RS01845	COG0255	Belongs to the universal ribosomal protein uL29 family
F1729_RS01850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1729_RS01855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1729_RS01860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1729_RS01865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1729_RS01870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1729_RS01875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1729_RS01880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1729_RS01885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1729_RS01890	COG0200	Binds to the 23S rRNA
F1729_RS01895	COG0201	protein transport
F1729_RS01900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1729_RS01905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1729_RS01910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1729_RS01915	COG0202	RNA polymerase activity
F1729_RS01920	COG0203	ribosomal protein L17
F1729_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS01980	COG0571	ribonuclease III activity
F1729_RS01985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS02010	COG1045	serine acetyltransferase
F1729_RS02015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1729_RS02075	COG2204	response regulator
F1729_RS02080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F1729_RS02090	COG0129	dihydroxy-acid dehydratase activity
F1729_RS02110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F1729_RS02115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F1729_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS02145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F1729_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS02155	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F1729_RS02185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1729_RS02190	COG1643	Atp-dependent helicase
F1729_RS02315	COG1136	(ABC) transporter
F1729_RS02325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS02345	COG4864	UPF0365 protein
F1729_RS02360	COG1058	Belongs to the CinA family
F1729_RS02360	COG1546	Belongs to the CinA family
F1729_RS02365	COG4717	serine-type aminopeptidase activity
F1729_RS02380	COG1073	alpha beta
F1729_RS02385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS02390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1729_RS02395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1729_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS02405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1729_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS02450	COG0569	domain protein
F1729_RS02505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1729_RS02570	COG3119	arylsulfatase activity
F1729_RS02575	COG3132	Protein of unknown function, DUF480
F1729_RS02580	COG2234	aminopeptidase activity
F1729_RS02590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1729_RS02605	COG3119	arylsulfatase activity
F1729_RS02620	COG3119	arylsulfatase activity
F1729_RS02625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F1729_RS02650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F1729_RS02670	COG0372	Belongs to the citrate synthase family
F1729_RS02675	COG0181	hydroxymethylbilane synthase activity
F1729_RS02685	COG1040	competence protein
F1729_RS02690	COG1233	COG1233 Phytoene dehydrogenase and related
F1729_RS02695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1729_RS02705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F1729_RS02710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F1729_RS02720	COG0657	acetylesterase activity
F1729_RS02755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1729_RS02810	COG0590	tRNA wobble adenosine to inosine editing
F1729_RS02825	COG3119	arylsulfatase activity
F1729_RS02850	COG1295	ribonuclease BN
F1729_RS02855	COG1902	pentaerythritol trinitrate reductase activity
F1729_RS02890	COG0784	Response regulator, receiver
F1729_RS02890	COG2205	protein histidine kinase activity
F1729_RS02900	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1729_RS02900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1729_RS02905	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1729_RS02915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1729_RS02925	COG3119	arylsulfatase activity
F1729_RS02935	COG3959	Transketolase, thiamine diphosphate binding domain
F1729_RS02940	COG3958	Transketolase
F1729_RS02955	COG3956	TIGRFAM MazG family protein
F1729_RS02970	COG0247	lactate metabolic process
F1729_RS02975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F1729_RS02980	COG0314	molybdopterin synthase activity
F1729_RS02985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1729_RS02990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1729_RS02995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS03005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS03010	COG1459	type II secretion system
F1729_RS03055	COG0740	serine-type endopeptidase activity
F1729_RS03060	COG0740	serine-type endopeptidase activity
F1729_RS03080	COG1475	DNA binding
F1729_RS03090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F1729_RS03105	COG1082	Xylose isomerase domain protein TIM barrel
F1729_RS03140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1729_RS03170	COG0673	inositol 2-dehydrogenase activity
F1729_RS03175	COG3119	arylsulfatase activity
F1729_RS03180	COG2095	MarC family integral membrane protein
F1729_RS03200	COG0842	Transport permease protein
F1729_RS03200	COG1129	ABC transporter
F1729_RS03250	COG1671	Belongs to the UPF0178 family
F1729_RS03255	COG0659	secondary active sulfate transmembrane transporter activity
F1729_RS03320	COG0577	efflux transmembrane transporter activity
F1729_RS03320	COG1136	(ABC) transporter
F1729_RS03340	COG1321	iron dependent repressor
F1729_RS03345	COG3119	arylsulfatase activity
F1729_RS03360	COG3119	arylsulfatase activity
F1729_RS03375	COG0584	glycerophosphoryl diester phosphodiesterase
F1729_RS03395	COG1061	Type III restriction enzyme res subunit
F1729_RS03410	COG0784	Response regulator, receiver
F1729_RS03410	COG2205	protein histidine kinase activity
F1729_RS03450	COG0673	inositol 2-dehydrogenase activity
F1729_RS03470	COG0714	Associated with various cellular activities
F1729_RS03545	COG1136	(ABC) transporter
F1729_RS03545	COG0577	efflux transmembrane transporter activity
F1729_RS03550	COG1136	(ABC) transporter
F1729_RS03550	COG0577	efflux transmembrane transporter activity
F1729_RS03585	COG0811	peptide transport
F1729_RS03600	COG4956	integral membrane protein (PIN domain superfamily)
F1729_RS03625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F1729_RS03630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1729_RS03640	COG0436	Aminotransferase
F1729_RS03650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1729_RS03675	COG3220	belongs to the UPF0276 family
F1729_RS03700	COG1381	Involved in DNA repair and RecF pathway recombination
F1729_RS03720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1729_RS03745	COG0826	peptidase U32
F1729_RS03795	COG2165	general secretion pathway protein
F1729_RS03800	COG1459	type II secretion system
F1729_RS03805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS03825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F1729_RS03830	COG2234	aminopeptidase activity
F1729_RS03830	COG4935	Belongs to the peptidase S8 family
F1729_RS03885	COG3961	Belongs to the TPP enzyme family
F1729_RS03890	COG0281	malic enzyme
F1729_RS03900	COG2957	Belongs to the agmatine deiminase family
F1729_RS03930	COG3119	arylsulfatase activity
F1729_RS03945	COG1053	succinate dehydrogenase
F1729_RS04000	COG2755	lipolytic protein G-D-S-L family
F1729_RS04000	COG0657	acetylesterase activity
F1729_RS04010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F1729_RS04030	COG3540	Alkaline phosphatase
F1729_RS04035	COG2205	protein histidine kinase activity
F1729_RS04035	COG5002	protein histidine kinase activity
F1729_RS04035	COG0784	Response regulator, receiver
F1729_RS04065	COG3119	arylsulfatase activity
F1729_RS04075	COG0736	holo-[acyl-carrier-protein] synthase activity
F1729_RS04085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS04095	COG0750	zinc metalloprotease
F1729_RS04110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F1729_RS04135	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F1729_RS04140	COG1419	protein localization to endoplasmic reticulum
F1729_RS04145	COG0455	bacterial-type flagellum organization
F1729_RS04155	COG1191	sigma factor activity
F1729_RS04160	COG0714	Associated with various cellular activities
F1729_RS04195	COG0039	L-malate dehydrogenase activity
F1729_RS04200	COG0235	Class ii aldolase
F1729_RS04235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1729_RS04240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
F1729_RS04250	COG4869	propanediol catabolic process
F1729_RS04255	COG1349	DNA-binding transcription factor activity
F1729_RS04265	COG2132	Multicopper oxidase
F1729_RS04280	COG3118	belongs to the thioredoxin family
F1729_RS04300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1729_RS04305	COG0109	protoheme IX farnesyltransferase activity
F1729_RS04320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1729_RS04325	COG0242	peptide deformylase activity
F1729_RS04390	COG0477	Major facilitator Superfamily
F1729_RS04420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1729_RS04450	COG0489	protein tyrosine kinase activity
F1729_RS04455	COG2166	iron-sulfur cluster assembly
F1729_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS04520	COG1070	Carbohydrate kinase
F1729_RS04535	COG1294	oxidase, subunit
F1729_RS04540	COG1271	oxidase subunit
F1729_RS04565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1729_RS04570	COG0432	Pfam Uncharacterised protein family UPF0047
F1729_RS04585	COG0673	inositol 2-dehydrogenase activity
F1729_RS04600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F1729_RS04610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1729_RS04615	COG0484	heat shock protein binding
F1729_RS04620	COG0459	protein refolding
F1729_RS04625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1729_RS04630	COG0459	protein refolding
F1729_RS04635	COG0004	ammonium transporteR
F1729_RS04645	COG0569	domain protein
F1729_RS04650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1729_RS04655	COG1078	dGTPase activity
F1729_RS04670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1729_RS04680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1729_RS04680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1729_RS04695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F1729_RS04695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F1729_RS04750	COG1017	nitric oxide dioxygenase activity
F1729_RS04750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1729_RS04780	COG3458	cephalosporin-C deacetylase activity
F1729_RS04785	COG3458	cephalosporin-C deacetylase activity
F1729_RS04795	COG0531	amino acid
F1729_RS04815	COG1247	-acetyltransferase
F1729_RS04825	COG0673	inositol 2-dehydrogenase activity
F1729_RS04830	COG0464	growth
F1729_RS04840	COG1846	Transcriptional regulator
F1729_RS04845	COG2226	methyltransferase
F1729_RS04850	COG0668	transmembrane transport
F1729_RS04875	COG1234	tRNA 3'-trailer cleavage
F1729_RS04880	COG0523	cobalamin synthesis protein
F1729_RS04895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1729_RS04895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1729_RS04900	COG0531	amino acid
F1729_RS04910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1729_RS04940	COG0519	Catalyzes the synthesis of GMP from XMP
F1729_RS04950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
F1729_RS04965	COG0156	8-amino-7-oxononanoate synthase activity
F1729_RS04970	COG1063	alcohol dehydrogenase
F1729_RS04975	COG1396	sequence-specific DNA binding
F1729_RS04990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F1729_RS05000	COG2204	response regulator
F1729_RS05005	COG0673	inositol 2-dehydrogenase activity
F1729_RS05015	COG1312	Catalyzes the dehydration of D-mannonate
F1729_RS05020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F1729_RS05030	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS05040	COG1414	Transcriptional regulator
F1729_RS05045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1729_RS05100	COG0300	oxidoreductase activity
F1729_RS05115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F1729_RS05125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1729_RS05125	COG0515	serine threonine protein kinase
F1729_RS05130	COG0539	negative regulation of cytoplasmic translation
F1729_RS05150	COG3119	arylsulfatase activity
F1729_RS05165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1729_RS05170	COG1136	(ABC) transporter
F1729_RS05175	COG0577	efflux transmembrane transporter activity
F1729_RS05175	COG1136	(ABC) transporter
F1729_RS05215	COG2192	nodulation
F1729_RS05245	COG0457	Tetratricopeptide repeat
F1729_RS05255	COG3119	arylsulfatase activity
F1729_RS05265	COG3119	arylsulfatase activity
F1729_RS05270	COG0673	inositol 2-dehydrogenase activity
F1729_RS05290	COG2186	Transcriptional regulator
F1729_RS05295	COG0174	glutamine synthetase
F1729_RS05315	COG0673	inositol 2-dehydrogenase activity
F1729_RS05325	COG2346	COG2346, Truncated hemoglobins
F1729_RS05355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F1729_RS05360	COG0248	Ppx GppA phosphatase
F1729_RS05365	COG1940	carbohydrate kinase activity
F1729_RS05385	COG1872	DUF167
F1729_RS05390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F1729_RS05400	COG2204	response regulator
F1729_RS05410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1729_RS05415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F1729_RS05420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1729_RS05430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1729_RS05440	COG0545	Peptidyl-prolyl cis-trans isomerase
F1729_RS05445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F1729_RS05560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS05595	COG2239	Acts as a magnesium transporter
F1729_RS05655	COG1088	dTDP-glucose 4,6-dehydratase activity
F1729_RS05665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1729_RS05675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F1729_RS05695	COG0659	secondary active sulfate transmembrane transporter activity
F1729_RS05720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F1729_RS05785	COG4285	Biotin-protein ligase, N terminal
F1729_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS05830	COG3119	arylsulfatase activity
F1729_RS05835	COG0563	adenylate kinase activity
F1729_RS05840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1729_RS05845	COG0726	polysaccharide deacetylase
F1729_RS05850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1729_RS05855	COG0318	PFAM AMP-dependent synthetase and ligase
F1729_RS05890	COG0372	Belongs to the citrate synthase family
F1729_RS05895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS05975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F1729_RS05990	COG2706	6-phosphogluconolactonase activity
F1729_RS05995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1729_RS06010	COG3119	arylsulfatase activity
F1729_RS06025	COG3119	arylsulfatase activity
F1729_RS06040	COG1363	Peptidase, m42
F1729_RS06045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1729_RS06060	COG3869	Catalyzes the specific phosphorylation of arginine residues in
F1729_RS06075	COG0537	adenosine 5'-monophosphoramidase activity
F1729_RS06090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F1729_RS06105	COG3408	Glycogen debranching enzyme
F1729_RS06105	COG3119	arylsulfatase activity
F1729_RS06115	COG3739	integral membrane protein
F1729_RS06135	COG0509	glycine decarboxylation via glycine cleavage system
F1729_RS06150	COG0142	geranyltranstransferase activity
F1729_RS06155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1729_RS06175	COG0673	inositol 2-dehydrogenase activity
F1729_RS06190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS06195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1729_RS06200	COG0575	Belongs to the CDS family
F1729_RS06210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1729_RS06215	COG0529	Catalyzes the synthesis of activated sulfate
F1729_RS06220	COG3119	arylsulfatase activity
F1729_RS06255	COG0616	signal peptide processing
F1729_RS06280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1729_RS06285	COG2088	sporulation resulting in formation of a cellular spore
F1729_RS06305	COG0300	oxidoreductase activity
F1729_RS06310	COG1902	pentaerythritol trinitrate reductase activity
F1729_RS06315	COG1192	Involved in chromosome partitioning
F1729_RS06320	COG2813	Specifically methylates the guanine in position
F1729_RS06320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1729_RS06325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1729_RS06330	COG1164	Oligoendopeptidase f
F1729_RS06335	COG1834	amidinotransferase
F1729_RS06370	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F1729_RS06405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F1729_RS06420	COG1216	Glycosyl transferase, family 2
F1729_RS06420	COG0438	transferase activity, transferring glycosyl groups
F1729_RS06460	COG1088	dTDP-glucose 4,6-dehydratase activity
F1729_RS06465	COG1215	transferase activity, transferring glycosyl groups
F1729_RS06475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F1729_RS06480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1729_RS06480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1729_RS06485	COG1051	belongs to the nudix hydrolase family
F1729_RS06485	COG1056	cytidyltransferase-related domain
F1729_RS06490	COG1335	isochorismatase
F1729_RS06495	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F1729_RS06500	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
F1729_RS06545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F1729_RS06550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F1729_RS06555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F1729_RS06560	COG5285	phytanoyl-CoA dioxygenase
F1729_RS06565	COG1917	Cupin 2, conserved barrel domain protein
F1729_RS06575	COG0456	acetyltransferase
F1729_RS06580	COG1846	Transcriptional regulator
F1729_RS06585	COG0584	glycerophosphoryl diester phosphodiesterase
F1729_RS06680	COG3119	arylsulfatase activity
F1729_RS06695	COG0346	lactoylglutathione lyase activity
F1729_RS06715	COG3119	arylsulfatase activity
F1729_RS06720	COG3119	arylsulfatase activity
F1729_RS06750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1729_RS06755	COG1073	alpha beta
F1729_RS06770	COG2226	methyltransferase
F1729_RS06785	COG0288	reversible hydration of carbon dioxide
F1729_RS06835	COG1131	(ABC) transporter
F1729_RS06850	COG0358	DNA primase activity
F1729_RS06855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS06885	COG2610	gluconate transmembrane transporter activity
F1729_RS06905	COG1082	Xylose isomerase domain protein TIM barrel
F1729_RS06910	COG0673	inositol 2-dehydrogenase activity
F1729_RS06935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1729_RS06940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F1729_RS06950	COG0463	Glycosyl transferase, family 2
F1729_RS06975	COG1082	Xylose isomerase domain protein TIM barrel
F1729_RS06980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F1729_RS07010	COG1918	ferrous iron import across plasma membrane
F1729_RS07010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F1729_RS07035	COG2186	Transcriptional regulator
F1729_RS07080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1729_RS07120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1729_RS07120	COG0519	Catalyzes the synthesis of GMP from XMP
F1729_RS07155	COG3119	arylsulfatase activity
F1729_RS07165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F1729_RS07190	COG1132	(ABC) transporter
F1729_RS07195	COG0534	Mate efflux family protein
F1729_RS07200	COG0095	Lipoate-protein ligase
F1729_RS07205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1729_RS07210	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1729_RS07215	COG3386	PFAM SMP-30 Gluconolaconase
F1729_RS07230	COG1695	Transcriptional regulator
F1729_RS07270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS07275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1729_RS07275	COG1796	DNA polymerase
F1729_RS07290	COG1469	GTP cyclohydrolase I activity
F1729_RS07310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1729_RS07320	COG1454	alcohol dehydrogenase
F1729_RS07325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1729_RS07345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1729_RS07365	COG0728	peptidoglycan biosynthetic process
F1729_RS07385	COG2115	Belongs to the xylose isomerase family
F1729_RS07395	COG2815	serine threonine protein kinase
F1729_RS07395	COG0515	serine threonine protein kinase
F1729_RS07460	COG0714	Associated with various cellular activities
F1729_RS07465	COG1657	PFAM Prenyltransferase squalene oxidase
F1729_RS07490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F1729_RS07495	COG0113	porphobilinogen synthase activity
F1729_RS07500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1729_RS07505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1729_RS07510	COG2855	membrane
F1729_RS07585	COG1368	sulfuric ester hydrolase activity
F1729_RS07620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F1729_RS07630	COG2766	serine protein kinase
F1729_RS07635	COG2718	Belongs to the UPF0229 family
F1729_RS07640	COG2719	SpoVR family
F1729_RS07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1729_RS07685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F1729_RS07700	COG0424	maF-like protein
F1729_RS07720	COG0653	protein targeting
F1729_RS07765	COG0531	amino acid
F1729_RS07770	COG2226	methyltransferase
F1729_RS07775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F1729_RS07780	COG3119	arylsulfatase activity
F1729_RS07790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1729_RS07795	COG0784	Response regulator, receiver
F1729_RS07795	COG2205	protein histidine kinase activity
F1729_RS07800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1729_RS07810	COG0489	protein tyrosine kinase activity
F1729_RS07815	COG2204	response regulator
F1729_RS07820	COG4191	Histidine kinase
F1729_RS07825	COG0297	glycogen (starch) synthase activity
F1729_RS07835	COG1449	Belongs to the glycosyl hydrolase 57 family
F1729_RS07850	COG2610	gluconate transmembrane transporter activity
F1729_RS07885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1729_RS07955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1729_RS07970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1729_RS07975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1729_RS07985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1729_RS07990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1729_RS07995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F1729_RS07995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1729_RS08000	COG0202	RNA polymerase activity
F1729_RS08010	COG0018	arginyl-trna synthetase
F1729_RS08015	COG0799	negative regulation of ribosome biogenesis
F1729_RS08020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F1729_RS08030	COG1774	PSP1 C-terminal conserved region
F1729_RS08045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1729_RS08050	COG0321	lipoyl(octanoyl) transferase activity
F1729_RS08075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1729_RS08080	COG0328	RNA-DNA hybrid ribonuclease activity
F1729_RS08085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1729_RS08095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1729_RS08120	COG0579	oxidoreductase
F1729_RS08125	COG1215	transferase activity, transferring glycosyl groups
F1729_RS08200	COG3663	DNA glycosylase
F1729_RS08205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1729_RS08210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1729_RS08230	COG1970	mechanosensitive ion channel activity
F1729_RS08275	COG1741	Belongs to the pirin family
F1729_RS08315	COG3588	fructose-bisphosphate aldolase
F1729_RS08340	COG4294	response to UV
F1729_RS08350	COG0640	Transcriptional regulator
F1729_RS08355	COG3189	MarR family transcriptional regulator
F1729_RS08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1729_RS08375	COG0798	PFAM Bile acid sodium symporter
F1729_RS08385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1729_RS08410	COG3541	Predicted nucleotidyltransferase
F1729_RS08435	COG0653	protein targeting
F1729_RS08475	COG0596	Alpha beta hydrolase
F1729_RS08485	COG1309	transcriptional regulator
F1729_RS08520	COG3152	Membrane
F1729_RS08525	COG3152	Membrane
F1729_RS08585	COG1802	Transcriptional regulator
F1729_RS08615	COG2308	Evidence 4 Homologs of previously reported genes of
F1729_RS08615	COG2307	Protein conserved in bacteria
F1729_RS08645	COG1067	ATP-dependent peptidase activity
F1729_RS08670	COG0530	calcium, potassium:sodium antiporter activity
F1729_RS08675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1729_RS08700	COG2204	response regulator
F1729_RS08720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1729_RS08760	COG3746	phosphate-selective porin O and P
F1729_RS08785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS08800	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F1729_RS08820	COG0166	Belongs to the GPI family
F1729_RS08870	COG0523	cobalamin synthesis protein
F1729_RS08885	COG0714	Associated with various cellular activities
F1729_RS08940	COG2801	Transposase and inactivated derivatives
F1729_RS08975	COG0714	Associated with various cellular activities
F1729_RS09030	COG0443	Heat shock 70 kDa protein
F1729_RS09035	COG0443	Heat shock 70 kDa protein
F1729_RS09330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1729_RS09340	COG0515	serine threonine protein kinase
F1729_RS09340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1729_RS09345	COG0673	inositol 2-dehydrogenase activity
F1729_RS09350	COG0456	acetyltransferase
F1729_RS09360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1729_RS09405	COG0084	hydrolase, TatD family'
F1729_RS09415	COG0848	biopolymer transport protein
F1729_RS09420	COG0811	peptide transport
F1729_RS09430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1729_RS09465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1729_RS09475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F1729_RS09480	COG0174	glutamine synthetase
F1729_RS09485	COG0071	Belongs to the small heat shock protein (HSP20) family
F1729_RS09505	COG3119	arylsulfatase activity
F1729_RS09520	COG0180	Tryptophanyl-tRNA synthetase
F1729_RS09525	COG0167	dihydroorotate dehydrogenase activity
F1729_RS09555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1729_RS09560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1729_RS09565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F1729_RS09570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1729_RS09615	COG4555	ABC transporter
F1729_RS09620	COG1668	transmembrane transport
F1729_RS09630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1729_RS09635	COG0673	inositol 2-dehydrogenase activity
F1729_RS09660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS09675	COG1132	(ABC) transporter
F1729_RS09680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1729_RS09695	COG1216	Glycosyl transferase, family 2
F1729_RS09700	COG2226	methyltransferase
F1729_RS09705	COG3119	arylsulfatase activity
F1729_RS09710	COG3119	arylsulfatase activity
F1729_RS09715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F1729_RS09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1729_RS09750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F1729_RS09755	COG0237	dephospho-CoA kinase activity
F1729_RS09775	COG1505	serine-type exopeptidase activity
F1729_RS09780	COG3119	arylsulfatase activity
F1729_RS09790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1729_RS09805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1729_RS09825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1729_RS09850	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
F1729_RS09860	COG4191	Histidine kinase
F1729_RS09865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F1729_RS09900	COG0788	formyltetrahydrofolate deformylase activity
F1729_RS09905	COG1573	uracil-dna glycosylase
F1729_RS09915	COG2755	lipolytic protein G-D-S-L family
F1729_RS09915	COG0657	acetylesterase activity
F1729_RS09925	COG0436	Aminotransferase
F1729_RS09930	COG2815	serine threonine protein kinase
F1729_RS09930	COG0515	serine threonine protein kinase
F1729_RS09940	COG2208	phosphoserine phosphatase activity
F1729_RS09945	COG1199	ATP-dependent helicase activity
F1729_RS09955	COG0515	serine threonine protein kinase
F1729_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS10030	COG1473	amidohydrolase
F1729_RS10035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F1729_RS10040	COG3119	arylsulfatase activity
F1729_RS10050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F1729_RS10065	COG3706	GGDEF domain
F1729_RS10105	COG0589	response to stress
F1729_RS10115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1729_RS10120	COG0594	ribonuclease P activity
F1729_RS10140	COG1136	(ABC) transporter
F1729_RS10150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1729_RS10170	COG1136	(ABC) transporter
F1729_RS10200	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1729_RS10205	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1729_RS10210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1729_RS10215	COG3002	Belongs to the UPF0753 family
F1729_RS10225	COG0288	reversible hydration of carbon dioxide
F1729_RS10230	COG1229	Formylmethanofuran dehydrogenase subunit A
F1729_RS10240	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1729_RS10245	COG1129	ABC transporter
F1729_RS10280	COG2207	Transcriptional regulator
F1729_RS10280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1729_RS10305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS10310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1729_RS10315	COG1233	COG1233 Phytoene dehydrogenase and related
F1729_RS10320	COG0644	oxidoreductase
F1729_RS10335	COG3030	protein affecting phage T7 exclusion by the F plasmid
F1729_RS10350	COG1538	Outer membrane efflux protein
F1729_RS10375	COG0671	phosphoesterase, PA-phosphatase related
F1729_RS10490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1729_RS10525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1729_RS10570	COG3119	arylsulfatase activity
F1729_RS10605	COG3119	arylsulfatase activity
F1729_RS10610	COG3119	arylsulfatase activity
F1729_RS10620	COG5441	Belongs to the UPF0261 family
F1729_RS10640	COG0563	adenylate kinase activity
F1729_RS10665	COG1253	flavin adenine dinucleotide binding
F1729_RS10690	COG0481	GTPase activity
F1729_RS10700	COG4964	Belongs to the GSP D family
F1729_RS10705	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
F1729_RS10725	COG1136	(ABC) transporter
F1729_RS10725	COG0577	efflux transmembrane transporter activity
F1729_RS10730	COG1136	(ABC) transporter
F1729_RS10740	COG2815	serine threonine protein kinase
F1729_RS10740	COG0515	serine threonine protein kinase
F1729_RS10785	COG3119	arylsulfatase activity
F1729_RS10810	COG0024	Methionine aminopeptidase
F1729_RS10880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1729_RS10895	COG0326	Molecular chaperone. Has ATPase activity
F1729_RS10940	COG1368	sulfuric ester hydrolase activity
F1729_RS10960	COG0673	inositol 2-dehydrogenase activity
F1729_RS10965	COG0475	glutathione-regulated potassium exporter activity
F1729_RS10965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1729_RS10975	COG0047	phosphoribosylformylglycinamidine synthase activity
F1729_RS11020	COG2205	protein histidine kinase activity
F1729_RS11020	COG0784	Response regulator, receiver
F1729_RS11030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS11050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F1729_RS11060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS11065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS11075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F1729_RS11080	COG1217	gtp-binding protein TYPA
F1729_RS11095	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1729_RS11125	COG0488	(ABC) transporter
F1729_RS11145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1729_RS11145	COG0515	serine threonine protein kinase
F1729_RS11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS11185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1729_RS11195	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1729_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS11215	COG3119	arylsulfatase activity
F1729_RS11250	COG4191	Histidine kinase
F1729_RS11270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1729_RS11295	COG1295	ribonuclease BN
F1729_RS11310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1729_RS11315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1729_RS11320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F1729_RS11340	COG0165	Argininosuccinate lyase
F1729_RS11345	COG0101	tRNA pseudouridine synthase activity
F1729_RS11360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1729_RS11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1729_RS11375	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1729_RS11385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS11390	COG1187	pseudouridine synthase activity
F1729_RS11395	COG0543	2 iron, 2 sulfur cluster binding
F1729_RS11430	COG3119	arylsulfatase activity
F1729_RS11440	COG2721	sulfolactate sulfo-lyase activity
F1729_RS11445	COG3119	arylsulfatase activity
F1729_RS11465	COG3781	membrane
F1729_RS11475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS11485	COG1555	photosystem II stabilization
F1729_RS11485	COG1596	polysaccharide export
F1729_RS11510	COG1968	undecaprenyl-diphosphatase activity
F1729_RS11525	COG1160	GTP binding
F1729_RS11530	COG0052	Belongs to the universal ribosomal protein uS2 family
F1729_RS11535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1729_RS11540	COG0528	UMP kinase activity
F1729_RS11560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1729_RS11565	COG0662	Cupin 2, conserved barrel domain protein
F1729_RS11565	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F1729_RS11570	COG4284	Utp--glucose-1-phosphate uridylyltransferase
F1729_RS11580	COG0254	rRNA binding
F1729_RS11585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1729_RS11590	COG2890	protein-(glutamine-N5) methyltransferase activity
F1729_RS11620	COG0772	Belongs to the SEDS family
F1729_RS11660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1729_RS11675	COG2815	serine threonine protein kinase
F1729_RS11675	COG0515	serine threonine protein kinase
F1729_RS11680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1729_RS11685	COG0456	acetyltransferase
F1729_RS11690	COG2207	Transcriptional regulator
F1729_RS11690	COG1609	Transcriptional regulator
F1729_RS11700	COG0673	inositol 2-dehydrogenase activity
F1729_RS11720	COG3119	arylsulfatase activity
F1729_RS11750	COG1573	uracil-dna glycosylase
F1729_RS11755	COG0516	GMP reductase activity
F1729_RS11755	COG0517	IMP dehydrogenase activity
F1729_RS11765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1729_RS11775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1729_RS11780	COG2373	Large extracellular alpha-helical protein
F1729_RS11795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1729_RS11800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1729_RS11805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F1729_RS11875	COG2211	Major facilitator Superfamily
F1729_RS11890	COG0268	Binds directly to 16S ribosomal RNA
F1729_RS11905	COG2046	Belongs to the sulfate adenylyltransferase family
F1729_RS11935	COG0673	inositol 2-dehydrogenase activity
F1729_RS11970	COG0424	maF-like protein
F1729_RS11975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1729_RS11985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F1729_RS11995	COG0745	RESPONSE REGULATOR receiver
F1729_RS12005	COG2706	6-phosphogluconolactonase activity
F1729_RS12010	COG0497	DNA recombination
F1729_RS12055	COG0457	Tetratricopeptide repeat
F1729_RS12070	COG0138	bifunctional purine biosynthesis protein purh
F1729_RS12085	COG0552	protein localization to endoplasmic reticulum
F1729_RS12090	COG1070	Carbohydrate kinase
F1729_RS12135	COG0148	phosphopyruvate hydratase activity
F1729_RS12200	COG3264	Mechanosensitive ion channel
F1729_RS12200	COG1511	domain protein
F1729_RS12220	COG4566	intracellular signal transduction
F1729_RS12235	COG1414	Transcriptional regulator
F1729_RS12280	COG4251	negative regulation of phosphorylation
F1729_RS12290	COG0745	RESPONSE REGULATOR receiver
F1729_RS12295	COG5002	protein histidine kinase activity
F1729_RS12300	COG0745	RESPONSE REGULATOR receiver
F1729_RS12305	COG0784	Response regulator, receiver
F1729_RS12320	COG4251	negative regulation of phosphorylation
F1729_RS12325	COG2197	response regulator
F1729_RS12330	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS12370	COG3119	arylsulfatase activity
F1729_RS12540	COG0326	Molecular chaperone. Has ATPase activity
F1729_RS12550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS12575	COG0848	biopolymer transport protein
F1729_RS12585	COG0811	peptide transport
F1729_RS12610	COG1201	RNA secondary structure unwinding
F1729_RS12625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1729_RS12630	COG1185	polyribonucleotide nucleotidyltransferase activity
F1729_RS12640	COG2204	response regulator
F1729_RS12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1729_RS12700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS12715	COG1136	(ABC) transporter
F1729_RS12805	COG3119	arylsulfatase activity
F1729_RS12815	COG0673	inositol 2-dehydrogenase activity
F1729_RS12860	COG0515	serine threonine protein kinase
F1729_RS12860	COG2815	serine threonine protein kinase
F1729_RS12905	COG5002	protein histidine kinase activity
F1729_RS12925	COG1045	serine acetyltransferase
F1729_RS12935	COG0726	polysaccharide deacetylase
F1729_RS12940	COG0297	glycogen (starch) synthase activity
F1729_RS12940	COG0438	transferase activity, transferring glycosyl groups
F1729_RS12950	COG0438	transferase activity, transferring glycosyl groups
F1729_RS12970	COG0488	(ABC) transporter
F1729_RS12980	COG3119	arylsulfatase activity
F1729_RS12995	COG0488	(ABC) transporter
F1729_RS13000	COG0023	Translation Initiation Factor
F1729_RS13010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1729_RS13030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1729_RS13035	COG0024	Methionine aminopeptidase
F1729_RS13085	COG2076	Multidrug Resistance protein
F1729_RS13100	COG4106	trans-aconitate 2-methyltransferase activity
F1729_RS13115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F1729_RS13125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1729_RS13160	COG0516	GMP reductase activity
F1729_RS13160	COG0517	IMP dehydrogenase activity
F1729_RS13180	COG2197	response regulator
F1729_RS13195	COG4191	Histidine kinase
F1729_RS13200	COG3119	arylsulfatase activity
F1729_RS13220	COG3119	arylsulfatase activity
F1729_RS13235	COG2319	Wd-40 repeat
F1729_RS13235	COG3903	Transcriptional regulator
F1729_RS13255	COG3119	arylsulfatase activity
F1729_RS13260	COG3119	arylsulfatase activity
F1729_RS13325	COG2815	serine threonine protein kinase
F1729_RS13325	COG0515	serine threonine protein kinase
F1729_RS13345	COG3459	Glycosyltransferase 36 associated
F1729_RS13355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1729_RS13355	COG0189	ligase activity
F1729_RS13360	COG1446	asparaginase
F1729_RS13385	COG3436	PFAM IS66 Orf2 family protein
F1729_RS13395	COG3328	transposase activity
F1729_RS13515	COG4372	Transposase
F1729_RS13545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1729_RS13620	COG3012	SEC-C Motif Domain Protein
F1729_RS13670	COG4268	DNA restriction-modification system
F1729_RS13675	COG1401	restriction endodeoxyribonuclease activity
F1729_RS13690	COG4717	serine-type aminopeptidase activity
F1729_RS13695	COG0420	3'-5' exonuclease activity
F1729_RS13725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1729_RS13730	COG1205	dead DEAH box helicase
F1729_RS13730	COG1111	helicase
F1729_RS13785	COG0673	inositol 2-dehydrogenase activity
F1729_RS13795	COG1477	protein flavinylation
F1729_RS13800	COG0066	3-isopropylmalate dehydratase activity
F1729_RS13805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1729_RS13810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1729_RS13815	COG0228	four-way junction DNA binding
F1729_RS13820	COG0336	Belongs to the RNA methyltransferase TrmD family
F1729_RS13825	COG0335	large ribosomal subunit rRNA binding
F1729_RS13840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS13850	COG0475	glutathione-regulated potassium exporter activity
F1729_RS13855	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F1729_RS13860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1729_RS13960	COG2815	serine threonine protein kinase
F1729_RS13960	COG0515	serine threonine protein kinase
F1729_RS13980	COG1215	transferase activity, transferring glycosyl groups
F1729_RS13995	COG2319	Wd-40 repeat
F1729_RS13995	COG4249	Peptidase C14 caspase catalytic subunit p20
F1729_RS14055	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F1729_RS14070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F1729_RS14080	COG0154	amidase activity
F1729_RS14105	COG3258	Cytochrome c
F1729_RS14190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1729_RS14195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1729_RS14200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1729_RS14205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1729_RS14210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1729_RS14215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1729_RS14220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1729_RS14225	COG0356	it plays a direct role in the translocation of protons across the membrane
F1729_RS14250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1729_RS14255	COG0440	acetolactate synthase activity
F1729_RS14260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F1729_RS14260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F1729_RS14300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F1729_RS14310	COG0714	Associated with various cellular activities
F1729_RS14370	COG3622	Belongs to the hyi family
F1729_RS14375	COG0473	3-isopropylmalate dehydrogenase activity
F1729_RS14390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1729_RS14410	COG0658	competence protein
F1729_RS14410	COG2333	competence protein COMEC
F1729_RS14435	COG0601	transmembrane transport
F1729_RS14440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1729_RS14455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F1729_RS14465	COG3119	arylsulfatase activity
F1729_RS14475	COG1090	epimerase
F1729_RS14480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1729_RS14490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1729_RS14495	COG1509	lysine 2,3-aminomutase activity
F1729_RS14500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1729_RS14505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS14520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS14545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1729_RS14560	COG2084	Dehydrogenase
F1729_RS14570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS14600	COG0205	6-phosphofructokinase activity
F1729_RS14610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1729_RS14620	COG2815	serine threonine protein kinase
F1729_RS14620	COG0515	serine threonine protein kinase
F1729_RS14630	COG1858	cytochrome C peroxidase
F1729_RS14640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F1729_RS14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1729_RS14655	COG1017	nitric oxide dioxygenase activity
F1729_RS14660	COG0437	4 iron, 4 sulfur cluster binding
F1729_RS14665	COG0243	molybdopterin cofactor binding
F1729_RS14675	COG1595	DNA-templated transcription, initiation
F1729_RS14735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F1729_RS14765	COG0246	Mannitol dehydrogenase
F1729_RS14845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1729_RS14845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1729_RS14865	COG1609	Transcriptional regulator
F1729_RS14865	COG2207	Transcriptional regulator
F1729_RS14880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F1729_RS14890	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS14905	COG0589	response to stress
F1729_RS14955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1729_RS14970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1729_RS15030	COG1802	Transcriptional regulator
F1729_RS15050	COG2271	Major facilitator Superfamily
F1729_RS15065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F1729_RS15100	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
F1729_RS15115	COG0393	Putative heavy-metal-binding
F1729_RS15145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F1729_RS15155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F1729_RS15165	COG1073	alpha beta
F1729_RS15170	COG3253	May function as heme-dependent peroxidase
F1729_RS15195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F1729_RS15200	COG0438	transferase activity, transferring glycosyl groups
F1729_RS15205	COG0367	asparagine synthase
F1729_RS15215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1729_RS15265	COG0714	Associated with various cellular activities
F1729_RS15285	COG4335	DNA alkylation repair
F1729_RS15320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1729_RS15325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1729_RS15360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F1729_RS15365	COG1899	peptidyl-lysine modification to peptidyl-hypusine
F1729_RS15440	COG4106	trans-aconitate 2-methyltransferase activity
F1729_RS15500	COG2207	Transcriptional regulator
F1729_RS15500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1729_RS15505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS15610	COG0589	response to stress
F1729_RS15615	COG0471	metal ion transport
F1729_RS15620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1729_RS15625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS15625	COG0706	membrane insertase activity
F1729_RS15630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F1729_RS15645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1729_RS15670	COG0285	dihydrofolate synthase activity
F1729_RS15690	COG4964	Belongs to the GSP D family
F1729_RS15725	COG0612	Peptidase, M16
F1729_RS15740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS15745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS15760	COG1283	sodium-dependent phosphate transmembrane transporter activity
F1729_RS15780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS15785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F1729_RS15790	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F1729_RS15795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1729_RS15800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1729_RS15805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F1729_RS15810	COG0154	amidase activity
F1729_RS15825	COG0642	Histidine kinase
F1729_RS15840	COG0429	hydrolase of the alpha beta-hydrolase fold
F1729_RS15855	COG0456	acetyltransferase
F1729_RS15860	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS15865	COG0612	Peptidase, M16
F1729_RS15870	COG0612	Peptidase, M16
F1729_RS15965	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F1729_RS15980	COG0386	Belongs to the glutathione peroxidase family
F1729_RS16000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1729_RS16030	COG0390	transport system, permease component
F1729_RS16040	COG0463	Glycosyl transferase, family 2
F1729_RS16045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1729_RS16060	COG4191	Histidine kinase
F1729_RS16065	COG0515	serine threonine protein kinase
F1729_RS16065	COG2815	serine threonine protein kinase
F1729_RS16075	COG0793	Belongs to the peptidase S41A family
F1729_RS16080	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1729_RS16145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1729_RS16210	COG0456	acetyltransferase
F1729_RS16215	COG4067	protein conserved in archaea
F1729_RS16215	COG0189	ligase activity
F1729_RS16245	COG2204	response regulator
F1729_RS16250	COG0438	transferase activity, transferring glycosyl groups
F1729_RS16300	COG5002	protein histidine kinase activity
F1729_RS16330	COG2815	serine threonine protein kinase
F1729_RS16330	COG0515	serine threonine protein kinase
F1729_RS16380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS16420	COG0673	inositol 2-dehydrogenase activity
F1729_RS16430	COG2815	serine threonine protein kinase
F1729_RS16430	COG0515	serine threonine protein kinase
F1729_RS16475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F1729_RS16495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F1729_RS16530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS16585	COG0202	RNA polymerase activity
F1729_RS16640	COG4974	Belongs to the 'phage' integrase family
F1729_RS16665	COG2963	transposase activity
F1729_RS16765	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F1729_RS16790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1729_RS16800	COG3842	ATPase activity
F1729_RS16805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F1729_RS16845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F1729_RS16850	COG2201	protein-glutamate methylesterase activity
F1729_RS16855	COG0745	RESPONSE REGULATOR receiver
F1729_RS16865	COG0835	chemotaxis
F1729_RS16870	COG0784	Response regulator, receiver
F1729_RS16870	COG0643	Histidine kinase
F1729_RS16870	COG2198	Histidine kinase
F1729_RS16880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1729_RS16890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1729_RS16895	COG0515	serine threonine protein kinase
F1729_RS16895	COG2815	serine threonine protein kinase
F1729_RS16920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1729_RS16930	COG1862	Preprotein translocase
F1729_RS16935	COG0343	queuine tRNA-ribosyltransferase activity
F1729_RS16945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F1729_RS16955	COG0859	PFAM glycosyl transferase family 9
F1729_RS16965	COG1595	DNA-templated transcription, initiation
F1729_RS16985	COG0124	histidyl-tRNA synthetase
F1729_RS17000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS17010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1729_RS17015	COG1994	Peptidase M50
F1729_RS17035	COG0745	RESPONSE REGULATOR receiver
F1729_RS17050	COG0515	serine threonine protein kinase
F1729_RS17050	COG2815	serine threonine protein kinase
F1729_RS17055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1729_RS17085	COG2815	serine threonine protein kinase
F1729_RS17085	COG0515	serine threonine protein kinase
F1729_RS17090	COG0540	Belongs to the ATCase OTCase family
F1729_RS17095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1729_RS17120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1729_RS17160	COG0463	Glycosyl transferase, family 2
F1729_RS17190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1729_RS17215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1729_RS17240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1729_RS17255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1729_RS17260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F1729_RS17265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1729_RS17290	COG0456	acetyltransferase
F1729_RS17295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1729_RS17300	COG0556	nucleotide-excision repair
F1729_RS17305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F1729_RS17310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F1729_RS17320	COG0802	atpase or kinase
F1729_RS17325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F1729_RS17340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1729_RS17345	COG1657	PFAM Prenyltransferase squalene oxidase
F1729_RS17365	COG0714	Associated with various cellular activities
F1729_RS17395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS17405	COG0539	negative regulation of cytoplasmic translation
F1729_RS17405	COG2183	response to ionizing radiation
F1729_RS17415	COG0463	Glycosyl transferase, family 2
F1729_RS17420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS17430	COG0596	Alpha beta hydrolase
F1729_RS17435	COG0156	8-amino-7-oxononanoate synthase activity
F1729_RS17455	COG0463	Glycosyl transferase, family 2
F1729_RS17545	COG0574	Belongs to the PEP-utilizing enzyme family
F1729_RS17545	COG3848	Pyruvate phosphate dikinase
F1729_RS17560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F1729_RS17580	COG0562	UDP-galactopyranose mutase
F1729_RS17645	COG3119	arylsulfatase activity
F1729_RS17655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1729_RS17670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F1729_RS17685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F1729_RS17685	COG0321	lipoyl(octanoyl) transferase activity
F1729_RS17710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1729_RS17735	COG4974	Belongs to the 'phage' integrase family
F1729_RS17775	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1729_RS17785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1729_RS17790	COG0512	Glutamine amidotransferase of anthranilate synthase
F1729_RS17800	COG1228	amidohydrolase
F1729_RS17805	COG3119	arylsulfatase activity
F1729_RS17820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F1729_RS17830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1729_RS17835	COG4692	amylo-alpha-1,6-glucosidase activity
F1729_RS17840	COG0277	FAD linked oxidase domain protein
F1729_RS17845	COG0277	FAD linked oxidase domain protein
F1729_RS17850	COG0247	lactate metabolic process
F1729_RS17855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1729_RS17890	COG2706	6-phosphogluconolactonase activity
F1729_RS17900	COG1595	DNA-templated transcription, initiation
F1729_RS17905	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS17910	COG0443	Heat shock 70 kDa protein
F1729_RS17925	COG0205	6-phosphofructokinase activity
F1729_RS17935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1729_RS17940	COG1234	tRNA 3'-trailer cleavage
F1729_RS17945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1729_RS17950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1729_RS17955	COG0667	Aldo Keto reductase
F1729_RS17965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1729_RS17970	COG3119	arylsulfatase activity
F1729_RS18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS18120	COG0445	tRNA wobble uridine modification
F1729_RS18125	COG0423	glycine-tRNA ligase activity
F1729_RS18130	COG2045	Belongs to the ComB family
F1729_RS18135	COG0151	Belongs to the GarS family
F1729_RS18140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F1729_RS18145	COG0019	diaminopimelate decarboxylase activity
F1729_RS18165	COG0363	glucosamine-6-phosphate deaminase activity
F1729_RS18170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1729_RS18180	COG2271	Major facilitator Superfamily
F1729_RS18185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1729_RS18200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1729_RS18205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1729_RS18210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1729_RS18315	COG0693	protein deglycase activity
F1729_RS18340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1729_RS18440	COG2226	methyltransferase
F1729_RS18455	COG1335	isochorismatase
F1729_RS18460	COG2076	Multidrug Resistance protein
F1729_RS18500	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1729_RS18505	COG1129	ABC transporter
F1729_RS18515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1729_RS18550	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS18570	COG0745	RESPONSE REGULATOR receiver
F1729_RS18575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F1729_RS18580	COG2813	Specifically methylates the guanine in position
F1729_RS18595	COG0515	serine threonine protein kinase
F1729_RS18595	COG2815	serine threonine protein kinase
F1729_RS18600	COG0825	malonyl-CoA metabolic process
F1729_RS18615	COG1490	D-aminoacyl-tRNA deacylase activity
F1729_RS18620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1729_RS18630	COG1606	tRNA processing
F1729_RS18640	COG2747	anti-sigma28 factor FlgM
F1729_RS18645	COG0735	belongs to the Fur family
F1729_RS18650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F1729_RS18655	COG0004	ammonium transporteR
F1729_RS18660	COG0347	Belongs to the P(II) protein family
F1729_RS18665	COG0347	Belongs to the P(II) protein family
F1729_RS18675	COG1482	cell wall glycoprotein biosynthetic process
F1729_RS18695	COG4964	Belongs to the GSP D family
F1729_RS18715	COG1073	alpha beta
F1729_RS18730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS18745	COG3852	Histidine kinase
F1729_RS18755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F1729_RS18760	COG1684	flagellar biosynthetic protein fliR
F1729_RS18765	COG1987	bacterial-type flagellum assembly
F1729_RS18770	COG1338	Plays a role in the flagellum-specific transport system
F1729_RS18790	COG1360	Flagellar Motor Protein
F1729_RS18800	COG1582	Flagellar protein (FlbD)
F1729_RS18805	COG1749	Flagellar hook protein flgE
F1729_RS18810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F1729_RS18830	COG1157	protein secretion by the type III secretion system
F1729_RS18840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F1729_RS18850	COG1677	Flagellar hook-basal body complex protein FliE
F1729_RS18855	COG1558	bacterial-type flagellum-dependent cell motility
F1729_RS18860	COG1815	bacterial-type flagellum-dependent cell motility
F1729_RS18865	COG2204	response regulator
F1729_RS18895	COG0275	rRNA processing
F1729_RS18900	COG2001	Belongs to the MraZ family
F1729_RS18905	COG0438	transferase activity, transferring glycosyl groups
F1729_RS18910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1729_RS18925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1729_RS18935	COG2204	response regulator
F1729_RS18940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1729_RS18965	COG0617	tRNA 3'-terminal CCA addition
F1729_RS18970	COG0673	inositol 2-dehydrogenase activity
F1729_RS18980	COG0542	response to heat
F1729_RS18985	COG0443	Heat shock 70 kDa protein
F1729_RS18995	COG0149	triose-phosphate isomerase activity
F1729_RS19005	COG1561	YicC-like family, N-terminal region
F1729_RS19010	COG0194	GDP metabolic process
F1729_RS19015	COG1758	RNA polymerase activity
F1729_RS19020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1729_RS19025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1729_RS19035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1729_RS19040	COG0525	valine-tRNA ligase activity
F1729_RS19070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1729_RS19080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1729_RS19085	COG1519	Transferase
F1729_RS19090	COG0653	protein targeting
F1729_RS19095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1729_RS19115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F1729_RS19120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1729_RS19125	COG0318	PFAM AMP-dependent synthetase and ligase
F1729_RS19130	COG2218	PFAM glutamate synthase alpha subunit domain protein
F1729_RS19150	COG2208	phosphoserine phosphatase activity
F1729_RS19155	COG1301	dicarboxylic acid transport
F1729_RS19160	COG0673	inositol 2-dehydrogenase activity
F1729_RS19175	COG1074	ATP-dependent DNA helicase activity
F1729_RS19185	COG0793	Belongs to the peptidase S41A family
F1729_RS19185	COG3409	Peptidoglycan-binding domain 1 protein
F1729_RS19190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1729_RS19230	COG1073	alpha beta
F1729_RS19285	COG5002	protein histidine kinase activity
F1729_RS19290	COG0745	RESPONSE REGULATOR receiver
F1729_RS19315	COG3118	belongs to the thioredoxin family
F1729_RS19335	COG1136	(ABC) transporter
F1729_RS19445	COG2207	Transcriptional regulator
F1729_RS19445	COG1609	Transcriptional regulator
F1729_RS19500	COG0515	serine threonine protein kinase
F1729_RS19500	COG2815	serine threonine protein kinase
F1729_RS19510	COG1842	Phage shock protein A
F1729_RS19545	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS19560	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS19575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1729_RS19660	COG1733	regulation of RNA biosynthetic process
F1729_RS19680	COG4372	Transposase
F1729_RS19690	COG3436	PFAM IS66 Orf2 family protein
F1729_RS19700	COG2963	transposase activity
F1729_RS19765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1729_RS19770	COG2130	NADP-dependent
F1729_RS19775	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS19780	COG2124	cytochrome p450
F1729_RS19805	COG0300	oxidoreductase activity
F1729_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS19835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1729_RS19840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1729_RS19840	COG2010	Cytochrome c
F1729_RS19850	COG3685	Protein conserved in bacteria
F1729_RS19855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1729_RS19860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1729_RS19875	COG2032	superoxide dismutase activity
F1729_RS19880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1729_RS19890	COG0530	calcium, potassium:sodium antiporter activity
F1729_RS19920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1729_RS19920	COG1042	CoA-binding domain protein
F1729_RS19920	COG0045	succinate-CoA ligase (ADP-forming) activity
F1729_RS19925	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1729_RS19935	COG0574	Belongs to the PEP-utilizing enzyme family
F1729_RS19935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1729_RS19940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1729_RS19970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1729_RS19970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1729_RS19980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1729_RS19990	COG0309	Hydrogenase expression formation protein (HypE)
F1729_RS19995	COG0409	Hydrogenase expression formation protein
F1729_RS20000	COG0298	carbon dioxide binding
F1729_RS20015	COG0375	protein maturation
F1729_RS20030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1729_RS20060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1729_RS20085	COG0515	serine threonine protein kinase
F1729_RS20085	COG2815	serine threonine protein kinase
F1729_RS20095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS20125	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS20250	COG4191	Histidine kinase
F1729_RS20255	COG2204	response regulator
F1729_RS20260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1729_RS20265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1729_RS20285	COG3119	arylsulfatase activity
F1729_RS20290	COG3119	arylsulfatase activity
F1729_RS20300	COG3119	arylsulfatase activity
F1729_RS20315	COG3422	double-strand break repair
F1729_RS20335	COG2226	methyltransferase
F1729_RS20345	COG1120	ATPase activity
F1729_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1729_RS20450	COG2226	methyltransferase
F1729_RS20465	COG2890	protein-(glutamine-N5) methyltransferase activity
F1729_RS20480	COG0583	DNA-binding transcription factor activity
F1729_RS20485	COG0753	catalase activity
F1729_RS20570	COG3420	alginic acid biosynthetic process
F1729_RS20600	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1729_RS20615	COG0527	aspartate kinase activity
F1729_RS20630	COG5002	protein histidine kinase activity
F1729_RS20630	COG2205	protein histidine kinase activity
F1729_RS20630	COG0784	Response regulator, receiver
F1729_RS20635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1729_RS20645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1729_RS20665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1729_RS20690	COG2808	Putative FMN-binding domain
F1729_RS20695	COG1418	mRNA catabolic process
F1729_RS20705	COG0037	tRNA processing
F1729_RS20715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1729_RS20725	COG2814	Major facilitator Superfamily
F1729_RS20745	COG2226	methyltransferase
F1729_RS20760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F1729_RS20770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1729_RS20780	COG0728	peptidoglycan biosynthetic process
F1729_RS20785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1729_RS20795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F1729_RS20800	COG2089	acid synthase
F1729_RS20810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F1729_RS20815	COG1083	cytidylyl-transferase
F1729_RS20825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F1729_RS20830	COG0367	asparagine synthase
F1729_RS20840	COG2226	methyltransferase
F1729_RS20915	COG0598	Magnesium transport protein CorA
F1729_RS20920	COG3153	acetyltransferase
F1729_RS20920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1729_RS20950	COG0189	ligase activity
F1729_RS20950	COG0569	domain protein
F1729_RS20955	COG0189	ligase activity
F1729_RS20955	COG4067	protein conserved in archaea
F1729_RS20990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1729_RS20990	COG0392	lysyltransferase activity
F1729_RS21000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1729_RS21005	COG1657	PFAM Prenyltransferase squalene oxidase
F1729_RS21075	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F1729_RS21080	COG0784	Response regulator, receiver
F1729_RS21080	COG2205	protein histidine kinase activity
F1729_RS21085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1729_RS21090	COG3437	response regulator, receiver
F1729_RS21090	COG2205	protein histidine kinase activity
F1729_RS21090	COG4999	Histidine kinase
F1729_RS21090	COG3850	Histidine kinase
F1729_RS21140	COG2204	response regulator
F1729_RS21145	COG4191	Histidine kinase
F1729_RS21180	COG3437	response regulator, receiver
F1729_RS21180	COG3850	Histidine kinase
F1729_RS21180	COG4999	Histidine kinase
F1729_RS21180	COG2205	protein histidine kinase activity
F1729_RS21190	COG5487	UPF0391 membrane protein
F1729_RS21210	COG3237	CsbD-like
F1729_RS21275	COG2815	serine threonine protein kinase
F1729_RS21275	COG0515	serine threonine protein kinase
F1729_RS21280	COG2815	serine threonine protein kinase
F1729_RS21280	COG0515	serine threonine protein kinase
F1729_RS21290	COG0515	serine threonine protein kinase
F1729_RS21290	COG2815	serine threonine protein kinase
F1729_RS21305	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F1729_RS21330	COG3119	arylsulfatase activity
F1729_RS21390	COG3119	arylsulfatase activity
F1729_RS21435	COG2755	lipolytic protein G-D-S-L family
F1729_RS21435	COG0657	acetylesterase activity
F1729_RS21480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F1729_RS21495	COG0072	phenylalanine-tRNA ligase activity
F1729_RS21500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1729_RS21545	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS21590	COG2188	Transcriptional regulator
F1729_RS21600	COG1802	Transcriptional regulator
F1729_RS21690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1729_RS21695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1729_RS21720	COG1609	Transcriptional regulator
F1729_RS21745	COG2755	lipolytic protein G-D-S-L family
F1729_RS21745	COG0657	acetylesterase activity
F1729_RS21770	COG1132	(ABC) transporter
F1729_RS21775	COG1858	cytochrome C peroxidase
F1729_RS21785	COG2217	Heavy metal translocating P-type atpase
F1729_RS21805	COG2010	Cytochrome c
F1729_RS21805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1729_RS21830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F1729_RS21835	COG0069	glutamate synthase activity
F1729_RS21840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1729_RS21880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1729_RS21885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F1729_RS21895	COG4555	ABC transporter
F1729_RS21950	COG1215	transferase activity, transferring glycosyl groups
F1729_RS21965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1729_RS21965	COG0662	Cupin 2, conserved barrel domain protein
F1729_RS21975	COG0693	protein deglycase activity
F1729_RS21985	COG1609	Transcriptional regulator
F1729_RS21985	COG2207	Transcriptional regulator
F1729_RS22000	COG0515	serine threonine protein kinase
F1729_RS22010	COG1802	Transcriptional regulator
F1729_RS22030	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS22035	COG3608	succinylglutamate desuccinylase aspartoacylase
F1729_RS22070	COG0667	Aldo Keto reductase
F1729_RS22080	COG1309	transcriptional regulator
F1729_RS22095	COG1764	response to oxidative stress
F1729_RS22115	COG3795	YCII-related domain
F1729_RS22120	COG3795	YCII-related domain
F1729_RS22150	COG4941	Belongs to the sigma-70 factor family
F1729_RS22170	COG1127	ABC transporter
F1729_RS22175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1729_RS22185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1729_RS22225	COG3119	arylsulfatase activity
F1729_RS22240	COG0318	PFAM AMP-dependent synthetase and ligase
F1729_RS22245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1729_RS22280	COG3228	Belongs to the MtfA family
F1729_RS22325	COG2801	Transposase and inactivated derivatives
F1729_RS22365	COG0542	response to heat
F1729_RS22375	COG3119	arylsulfatase activity
F1729_RS22410	COG1706	bacterial-type flagellum-dependent cell motility
F1729_RS22420	COG0513	Belongs to the DEAD box helicase family
F1729_RS22430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F1729_RS22495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F1729_RS22515	COG0582	viral genome integration into host DNA
F1729_RS22640	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F1729_RS22660	COG1283	sodium-dependent phosphate transmembrane transporter activity
F1729_RS22670	COG0673	inositol 2-dehydrogenase activity
F1729_RS22695	COG2985	domain, Protein
F1729_RS22695	COG0490	domain, Protein
F1729_RS22705	COG1690	Belongs to the RtcB family
F1729_RS22740	COG0640	Transcriptional regulator
F1729_RS22745	COG0505	Belongs to the CarA family
F1729_RS22750	COG0105	UTP biosynthetic process
F1729_RS22755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F1729_RS22760	COG0045	succinate-CoA ligase (ADP-forming) activity
F1729_RS22775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1729_RS22780	COG0745	RESPONSE REGULATOR receiver
F1729_RS22805	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS22815	COG0305	Participates in initiation and elongation during chromosome replication
F1729_RS22820	COG0359	binds to the 23S rRNA
F1729_RS22825	COG0629	single-stranded DNA binding
F1729_RS22835	COG0193	aminoacyl-tRNA hydrolase activity
F1729_RS22840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1729_RS22860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1729_RS22885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1729_RS22895	COG1073	alpha beta
F1729_RS22925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1729_RS22930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1729_RS22940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1729_RS22950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1729_RS22965	COG0142	geranyltranstransferase activity
F1729_RS22970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1729_RS23000	COG0793	Belongs to the peptidase S41A family
F1729_RS23005	COG0167	dihydroorotate dehydrogenase activity
F1729_RS23010	COG1131	(ABC) transporter
F1729_RS23035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1729_RS23045	COG1053	succinate dehydrogenase
F1729_RS23055	COG0557	exoribonuclease II activity
F1729_RS23065	COG0442	prolyl-tRNA aminoacylation
F1729_RS23075	COG3119	arylsulfatase activity
F1729_RS23105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1729_RS23130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1729_RS23135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS23140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1729_RS23145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1729_RS23150	COG1757	Na H antiporter
F1729_RS23155	COG3852	Histidine kinase
F1729_RS23160	COG0745	RESPONSE REGULATOR receiver
F1729_RS23165	COG0445	tRNA wobble uridine modification
F1729_RS23180	COG0217	transcriptional regulatory protein
F1729_RS23195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1729_RS23200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1729_RS23200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1729_RS23205	COG0195	Participates in both transcription termination and antitermination
F1729_RS23215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS23220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1729_RS23225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1729_RS23230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F1729_RS23235	COG0416	fatty acid biosynthetic process
F1729_RS23240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1729_RS23280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F1729_RS23285	COG0564	pseudouridine synthase activity
F1729_RS23295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1729_RS23300	COG0670	Belongs to the BI1 family
F1729_RS23310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1729_RS23315	COG4336	lyase activity
F1729_RS23325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1729_RS23330	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
F1729_RS23345	COG2226	methyltransferase
F1729_RS23350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1729_RS23355	COG0698	ribose 5-phosphate isomerase
F1729_RS23360	COG0509	glycine decarboxylation via glycine cleavage system
F1729_RS23365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1729_RS23370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1729_RS23375	COG0095	Lipoate-protein ligase
F1729_RS23400	COG1595	DNA-templated transcription, initiation
F1729_RS23420	COG2208	phosphoserine phosphatase activity
F1729_RS23420	COG2770	Histidine kinase
F1729_RS23430	COG1904	glucuronate isomerase
F1729_RS23450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1729_RS23450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1729_RS23460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS23465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1729_RS23470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1729_RS23475	COG0154	amidase activity
F1729_RS23480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1729_RS23485	COG2151	metal-sulfur cluster biosynthetic enzyme
F1729_RS23495	COG0719	Fe-S assembly protein
F1729_RS23500	COG0719	Fe-S assembly protein
F1729_RS23515	COG1115	amino acid carrier protein
F1729_RS23545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1729_RS23550	COG0631	protein serine/threonine phosphatase activity
F1729_RS23570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1729_RS23585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1729_RS23585	COG0574	Belongs to the PEP-utilizing enzyme family
F1729_RS23590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1729_RS23610	COG3118	belongs to the thioredoxin family
F1729_RS23635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1729_RS23660	COG0287	Prephenate dehydrogenase
F1729_RS23665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1729_RS23670	COG0714	Associated with various cellular activities
F1729_RS23715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS23720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1729_RS23735	COG0483	inositol monophosphate 1-phosphatase activity
F1729_RS23785	COG0673	inositol 2-dehydrogenase activity
F1729_RS23795	COG1393	Belongs to the ArsC family
F1729_RS23840	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
F1729_RS23875	COG1595	DNA-templated transcription, initiation
F1729_RS23880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1729_RS23885	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
F1729_RS23915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1729_RS23925	COG1131	(ABC) transporter
F1729_RS23950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1729_RS23965	COG3386	PFAM SMP-30 Gluconolaconase
F1729_RS23990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1729_RS24010	COG2835	tetraacyldisaccharide 4'-kinase activity
F1729_RS24010	COG1663	tetraacyldisaccharide 4'-kinase activity
F1729_RS24020	COG1802	Transcriptional regulator
F1729_RS24025	COG0673	inositol 2-dehydrogenase activity
F1729_RS24030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F1729_RS24040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1729_RS24050	COG2183	response to ionizing radiation
F1729_RS24065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1729_RS24070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1729_RS24140	COG2081	HI0933 family
F1729_RS24155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1729_RS24160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1729_RS24200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F1729_RS24205	COG0163	prenyltransferase activity
F1729_RS24210	COG2226	methyltransferase
F1729_RS24215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F1729_RS24220	COG0385	Bile acid
F1729_RS24250	COG0215	cysteine-tRNA ligase activity
F1729_RS24255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F1729_RS24260	COG0632	four-way junction helicase activity
F1729_RS24285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1729_RS24290	COG2146	nitrite reductase [NAD(P)H] activity
F1729_RS24295	COG1560	Kdo2-lipid A biosynthetic process
F1729_RS24345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1729_RS24350	COG0482	sulfurtransferase activity
F1729_RS24370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1729_RS24385	COG0438	transferase activity, transferring glycosyl groups
F1729_RS24395	COG1408	metallophosphoesterase
F1729_RS24440	COG0515	serine threonine protein kinase
F1729_RS24555	COG2814	Major facilitator Superfamily
F1729_RS24585	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F1729_RS24605	COG1477	protein flavinylation
F1729_RS24640	COG0515	serine threonine protein kinase
F1729_RS24670	COG3119	arylsulfatase activity
F1729_RS24680	COG1446	asparaginase
F1729_RS24685	COG3119	arylsulfatase activity
F1729_RS24700	COG0515	serine threonine protein kinase
F1729_RS24705	COG1959	2 iron, 2 sulfur cluster binding
F1729_RS24715	COG3447	MASE1 domain protein
F1729_RS24715	COG5001	Diguanylate cyclase
F1729_RS24715	COG5002	protein histidine kinase activity
F1729_RS24775	COG1562	ergosterol biosynthetic process
F1729_RS24820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1729_RS24835	COG4964	Belongs to the GSP D family
F1729_RS24850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F1729_RS24860	COG0673	inositol 2-dehydrogenase activity
F1729_RS24865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F1729_RS24875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F1729_RS24875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F1729_RS24890	COG5285	phytanoyl-CoA dioxygenase
F1729_RS24925	COG1714	RDD family
F1729_RS24990	COG0493	'glutamate synthase
F1729_RS24995	COG0067	glutamate synthase
F1729_RS24995	COG0070	glutamate synthase
F1729_RS24995	COG0069	glutamate synthase activity
F1729_RS25015	COG2329	Antibiotic biosynthesis monooxygenase
F1729_RS25045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1729_RS25060	COG0109	protoheme IX farnesyltransferase activity
F1729_RS25065	COG1845	cytochrome c oxidase, subunit III
F1729_RS25075	COG1131	(ABC) transporter
F1729_RS25085	COG2322	membrane
F1729_RS25105	COG1120	ATPase activity
F1729_RS25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1729_RS25115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1729_RS25120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1729_RS25145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1729_RS25145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1729_RS25155	COG1160	GTP binding
F1729_RS25170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1729_RS25175	COG2239	Acts as a magnesium transporter
F1729_RS25185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1729_RS25215	COG1706	bacterial-type flagellum-dependent cell motility
F1729_RS25220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F1729_RS25230	COG4786	Flagellar basal body rod
F1729_RS25235	COG4786	Flagellar basal body rod
F1729_RS25240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS25270	COG4145	pantothenate transmembrane transporter activity
F1729_RS25310	COG2815	serine threonine protein kinase
F1729_RS25310	COG0515	serine threonine protein kinase
F1729_RS25360	COG1247	-acetyltransferase
F1729_RS25390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1729_RS25395	COG0443	Heat shock 70 kDa protein
F1729_RS25405	COG4536	flavin adenine dinucleotide binding
F1729_RS25415	COG0142	geranyltranstransferase activity
F1729_RS25420	COG0315	cyclic pyranopterin monophosphate synthase activity
F1729_RS25425	COG1196	nuclear chromosome segregation
F1729_RS25490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1729_RS25505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F1729_RS25510	COG2078	PFAM AMMECR1 domain protein
F1729_RS25530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1729_RS25540	COG0564	pseudouridine synthase activity
F1729_RS25570	COG0477	Major facilitator Superfamily
F1729_RS25595	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F1729_RS25620	COG0673	inositol 2-dehydrogenase activity
F1729_RS25645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1729_RS25650	COG0698	ribose 5-phosphate isomerase
F1729_RS25670	COG1473	amidohydrolase
F1729_RS25675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1729_RS25680	COG0322	excinuclease ABC activity
F1729_RS25695	COG1064	alcohol dehydrogenase
F1729_RS25790	COG2169	Transcriptional regulator
F1729_RS25790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1729_RS25805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1729_RS25895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F1729_RS25900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F1729_RS25905	COG0602	queuosine metabolic process
F1729_RS25910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F1729_RS25930	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS25950	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1729_RS25980	COG0713	ATP synthesis coupled electron transport
F1729_RS26010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1729_RS26045	COG0131	Imidazoleglycerol-phosphate dehydratase
F1729_RS26050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1729_RS26055	COG0012	GTP binding
F1729_RS26065	COG1215	transferase activity, transferring glycosyl groups
F1729_RS26085	COG0859	PFAM glycosyl transferase family 9
F1729_RS26090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1729_RS26090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1729_RS26105	COG0686	Belongs to the AlaDH PNT family
F1729_RS26125	COG0133	tryptophan synthase activity
F1729_RS26130	COG0159	tryptophan synthase activity
F1729_RS26140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F1729_RS26165	COG0339	signal peptide processing
F1729_RS26215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1729_RS26220	COG0673	inositol 2-dehydrogenase activity
F1729_RS26225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1729_RS26230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F1729_RS26245	COG2211	Major facilitator Superfamily
F1729_RS26295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1729_RS26305	COG0745	RESPONSE REGULATOR receiver
F1729_RS26315	COG0742	ribosomal rna small subunit methyltransferase
F1729_RS26340	COG2755	lipolytic protein G-D-S-L family
F1729_RS26350	COG0284	orotidine-5'-phosphate decarboxylase activity
F1729_RS26355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F1729_RS26360	COG0604	alcohol dehydrogenase
F1729_RS26380	COG4948	Mandelate Racemase Muconate Lactonizing
F1729_RS26405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1729_RS26455	COG0657	acetylesterase activity
F1729_RS26535	COG3118	belongs to the thioredoxin family
F1729_RS26535	COG0492	ferredoxin-NADP+ reductase activity
F1729_RS26545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1729_RS26545	COG1333	cytochrome c biogenesis protein
F1729_RS26560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1729_RS26565	COG0174	glutamine synthetase
F1729_RS26570	COG1785	Belongs to the alkaline phosphatase family
F1729_RS26590	COG1077	Cell shape determining protein MreB Mrl
F1729_RS26600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1729_RS26605	COG0673	inositol 2-dehydrogenase activity
F1729_RS26610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1729_RS26640	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
F1729_RS26645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F1729_RS26665	COG2824	Alkylphosphonate utilization operon protein PhnA
F1729_RS26685	COG1609	Transcriptional regulator
F1729_RS26685	COG2207	Transcriptional regulator
F1729_RS26700	COG2815	serine threonine protein kinase
F1729_RS26700	COG0515	serine threonine protein kinase
F1729_RS26710	COG0673	inositol 2-dehydrogenase activity
F1729_RS26715	COG1609	Transcriptional regulator
F1729_RS26715	COG2207	Transcriptional regulator
F1729_RS26725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1729_RS26760	COG0745	RESPONSE REGULATOR receiver
F1729_RS26765	COG0704	Plays a role in the regulation of phosphate uptake
F1729_RS26770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1729_RS26785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F1729_RS26790	COG5002	protein histidine kinase activity
F1729_RS26845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1729_RS26850	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1729_RS26855	COG5285	phytanoyl-CoA dioxygenase
F1729_RS26860	COG0126	phosphoglycerate kinase activity
F1729_RS26865	COG0233	cytoplasmic translational termination
F1729_RS26870	COG0516	GMP reductase activity
F1729_RS26880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1729_RS26890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1729_RS26905	COG1663	tetraacyldisaccharide 4'-kinase activity
F1729_RS26925	COG2815	serine threonine protein kinase
F1729_RS26925	COG0515	serine threonine protein kinase
F1729_RS26930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1729_RS26935	COG2226	methyltransferase
F1729_RS26950	COG0402	S-adenosylhomocysteine deaminase activity
F1729_RS26955	COG1668	transmembrane transport
F1729_RS26960	COG4555	ABC transporter
F1729_RS26965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1729_RS26970	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F1729_RS26975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F1729_RS26980	COG0657	acetylesterase activity
F1729_RS26985	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1729_RS26990	COG1121	(ABC) transporter
F1729_RS26995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1729_RS26995	COG1321	iron dependent repressor
F1729_RS27000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1729_RS27020	COG1414	Transcriptional regulator
F1729_RS27025	COG3706	GGDEF domain
F1729_RS27055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1729_RS27070	COG1530	ribonuclease E activity
F1729_RS27075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1729_RS27080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1729_RS27085	COG0673	inositol 2-dehydrogenase activity
F1729_RS27090	COG0483	inositol monophosphate 1-phosphatase activity
F1729_RS27095	COG0471	metal ion transport
F1729_RS27095	COG3273	potassium ion transport
F1729_RS27110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1729_RS27125	COG1570	exodeoxyribonuclease VII activity
F1729_RS27135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F1729_RS27140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1729_RS27160	COG3119	arylsulfatase activity
F1729_RS27185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1729_RS27195	COG1012	belongs to the aldehyde dehydrogenase family
F1729_RS27205	COG0137	argininosuccinate synthase activity
F1729_RS27210	COG0459	protein refolding
F1729_RS27215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1729_RS27230	COG0805	protein transport
F1729_RS27250	COG3876	Protein conserved in bacteria
F1729_RS27255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1729_RS27255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1729_RS27270	COG1058	Belongs to the CinA family
F1729_RS27270	COG1546	Belongs to the CinA family
F1729_RS27275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1729_RS27290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1729_RS27310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1729_RS27325	COG0495	leucyl-tRNA aminoacylation
F1729_RS27355	COG2135	peptidase activity
F1729_RS27360	COG0667	Aldo Keto reductase
F1729_RS27365	COG2197	response regulator
F1729_RS27375	COG0745	RESPONSE REGULATOR receiver
F1729_RS27380	COG3706	GGDEF domain
F1729_RS27405	COG1940	carbohydrate kinase activity
F1729_RS27410	COG0668	transmembrane transport
F1729_RS27420	COG3608	succinylglutamate desuccinylase aspartoacylase
F1729_RS27430	COG2971	BadF BadG BcrA BcrD
F1729_RS27435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F1729_RS27475	COG3119	arylsulfatase activity
F1729_RS27480	COG3119	arylsulfatase activity
F1729_RS27485	COG3119	arylsulfatase activity
F1729_RS27560	COG0439	Biotin carboxylase
F1729_RS27565	COG0511	ligase activity, forming carbon-carbon bonds
F1729_RS27570	COG0006	proline dipeptidase activity
F1729_RS27580	COG0710	3-dehydroquinate dehydratase activity
F1729_RS27630	COG0811	peptide transport
F1729_RS27665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1729_RS27670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1729_RS27675	COG1376	ErfK ybiS ycfS ynhG family protein
F1729_RS27680	COG1136	(ABC) transporter
F1729_RS27685	COG0577	efflux transmembrane transporter activity
F1729_RS27685	COG1136	(ABC) transporter
F1729_RS27725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1729_RS27735	COG0673	inositol 2-dehydrogenase activity
F1729_RS27765	COG0714	Associated with various cellular activities
F1729_RS27775	COG2204	response regulator
F1729_RS27845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1729_RS27850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F1729_RS27860	COG1678	Uncharacterized ACR, COG1678
F1729_RS27865	COG2017	converts alpha-aldose to the beta-anomer
F1729_RS27885	COG0714	Associated with various cellular activities
F1729_RS27905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1729_RS27965	COG1136	(ABC) transporter
F1729_RS27970	COG4591	ABC-type transport system involved in lipoprotein release permease component
F1729_RS27975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1729_RS27980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F1729_RS28010	COG0438	transferase activity, transferring glycosyl groups
F1729_RS28025	COG0436	Aminotransferase
F1729_RS28075	COG0107	imidazoleglycerol-phosphate synthase activity
F1729_RS28095	COG0114	fumarate hydratase activity
F1729_RS28110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1729_RS28120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS28150	COG2815	serine threonine protein kinase
F1729_RS28150	COG0515	serine threonine protein kinase
F1729_RS28200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F1729_RS28210	COG1335	isochorismatase
F1729_RS28270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F1729_RS28320	COG3119	arylsulfatase activity
F1729_RS28370	COG0519	Catalyzes the synthesis of GMP from XMP
F1729_RS28380	COG2207	Transcriptional regulator
F1729_RS28380	COG1609	Transcriptional regulator
F1729_RS28400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1729_RS28405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F1729_RS28410	COG1063	alcohol dehydrogenase
F1729_RS28425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1729_RS28505	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1729_RS28540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1729_RS28545	COG1691	(AIR) carboxylase
F1729_RS28555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F1729_RS28570	COG0584	glycerophosphoryl diester phosphodiesterase
F1729_RS28580	COG2022	thiamine diphosphate biosynthetic process
F1729_RS28590	COG0740	serine-type endopeptidase activity
F1729_RS28600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1729_RS28640	COG0515	serine threonine protein kinase
F1729_RS28640	COG2815	serine threonine protein kinase
F1729_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS28765	COG5650	phosphatidylinositol metabolic process
F1729_RS28790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1729_RS28795	COG0187	DNA topoisomerase II activity
F1729_RS28835	COG1459	type II secretion system
F1729_RS28840	COG1459	type II secretion system
F1729_RS28865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1729_RS28870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F1729_RS28930	COG3546	catalase activity
F1729_RS28940	COG0443	Heat shock 70 kDa protein
F1729_RS29005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1729_RS29030	COG1476	TRANSCRIPTIONal
F1729_RS29050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1729_RS29130	COG3119	arylsulfatase activity
F1729_RS29175	COG0657	acetylesterase activity
F1729_RS29185	COG1028	Short-chain dehydrogenase reductase Sdr
F1729_RS29200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1729_RS29205	COG4864	UPF0365 protein
F1729_RS29220	COG0667	Aldo Keto reductase
F1729_RS29225	COG0247	lactate metabolic process
F1729_RS29230	COG1139	Iron-sulfur cluster binding protein
F1729_RS29235	COG1556	Lactate utilization protein
F1729_RS29250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F1729_RS29255	COG0187	DNA topoisomerase II activity
F1729_RS29265	COG0592	DNA-directed DNA polymerase activity
F1729_RS29270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1729_RS29280	COG0628	permease
F1729_RS29285	COG1459	type II secretion system
F1729_RS29295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1729_RS29305	COG3706	GGDEF domain
F1729_RS29310	COG0745	RESPONSE REGULATOR receiver
F1729_RS29315	COG5002	protein histidine kinase activity
F1729_RS29380	COG0354	folic acid binding
F1729_RS29390	COG0436	Aminotransferase
F1729_RS29405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1729_RS29420	COG3119	arylsulfatase activity
F1729_RS29435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F1729_RS29440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F1729_RS29450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1729_RS29480	COG1846	Transcriptional regulator
F1729_RS29480	COG0456	acetyltransferase
F1729_RS29485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1729_RS29495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1729_RS29500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F1729_RS29505	COG0300	oxidoreductase activity
F1729_RS29510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1729_RS29515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1729_RS29520	COG0720	synthase
F1729_RS29530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1729_RS29535	COG2378	regulation of single-species biofilm formation
F1729_RS29565	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
F1729_RS29575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1729_RS29580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F1729_RS29580	COG3608	succinylglutamate desuccinylase aspartoacylase
F1729_RS29685	COG2207	Transcriptional regulator
F1729_RS29690	COG1073	alpha beta
F1729_RS29770	COG0778	Nitroreductase