locus-tag	class	description
B4X03_RS00040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4X03_RS00040	COG2190	(PTS) system
B4X03_RS00040	COG1263	PTS System
B4X03_RS00080	COG0697	spore germination
B4X03_RS00095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4X03_RS00100	COG0616	signal peptide processing
B4X03_RS00110	COG0811	peptide transport
B4X03_RS00115	COG0848	biopolymer transport protein
B4X03_RS00120	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B4X03_RS00130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4X03_RS00135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B4X03_RS00140	COG1380	Effector of murein hydrolase LrgA
B4X03_RS00145	COG0861	Integral membrane protein TerC family
B4X03_RS00175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4X03_RS00180	COG0785	Cytochrome C biogenesis protein
B4X03_RS00185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4X03_RS00185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4X03_RS00195	COG1595	DNA-templated transcription, initiation
B4X03_RS00255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4X03_RS00295	COG0321	lipoyl(octanoyl) transferase activity
B4X03_RS00310	COG2921	Belongs to the UPF0250 family
B4X03_RS00315	COG1686	Belongs to the peptidase S11 family
B4X03_RS00325	COG0772	Belongs to the SEDS family
B4X03_RS00330	COG0768	penicillin binding
B4X03_RS00335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4X03_RS00340	COG0799	negative regulation of ribosome biogenesis
B4X03_RS00360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4X03_RS00360	COG1263	PTS System
B4X03_RS00360	COG2190	(PTS) system
B4X03_RS00400	COG0697	spore germination
B4X03_RS00415	COG4143	(ABC) transporter
B4X03_RS00420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4X03_RS00435	COG0436	Aminotransferase
B4X03_RS00440	COG1169	isochorismate synthase
B4X03_RS00445	COG0671	phosphoesterase, PA-phosphatase related
B4X03_RS00450	COG1940	carbohydrate kinase activity
B4X03_RS00460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4X03_RS00465	COG0575	Belongs to the CDS family
B4X03_RS00470	COG0750	zinc metalloprotease
B4X03_RS00485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B4X03_RS00490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4X03_RS00500	COG0527	aspartate kinase activity
B4X03_RS00500	COG0460	homoserine dehydrogenase
B4X03_RS00510	COG1605	Chorismate mutase
B4X03_RS00510	COG0287	Prephenate dehydrogenase
B4X03_RS00515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B4X03_RS00520	COG0859	PFAM glycosyl transferase family 9
B4X03_RS00525	COG2920	part of a sulfur-relay system
B4X03_RS00530	COG0737	Belongs to the 5'-nucleotidase family
B4X03_RS00535	COG1115	amino acid carrier protein
B4X03_RS00540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
B4X03_RS00545	COG3683	transport system, periplasmic component
B4X03_RS00585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4X03_RS00595	COG2017	converts alpha-aldose to the beta-anomer
B4X03_RS00605	COG1085	galactose-1-phosphate uridylyltransferase
B4X03_RS00625	COG0642	Histidine kinase
B4X03_RS00630	COG0745	RESPONSE REGULATOR receiver
B4X03_RS00655	COG2003	Belongs to the UPF0758 family
B4X03_RS00660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4X03_RS00705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4X03_RS00710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4X03_RS00720	COG0513	Belongs to the DEAD box helicase family
B4X03_RS00735	COG0456	acetyltransferase
B4X03_RS00745	COG0497	DNA recombination
B4X03_RS00785	COG0728	peptidoglycan biosynthetic process
B4X03_RS00790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4X03_RS00795	COG3719	Belongs to the RNase T2 family
B4X03_RS00810	COG1584	GPR1 FUN34 yaaH family protein
B4X03_RS00815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4X03_RS00820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4X03_RS00835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4X03_RS00865	COG3161	chorismate lyase activity
B4X03_RS00875	COG0180	Tryptophanyl-tRNA synthetase
B4X03_RS00900	COG0387	Pfam Sodium calcium exchanger
B4X03_RS00905	COG3681	Belongs to the UPF0597 family
B4X03_RS00925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B4X03_RS00930	COG0594	ribonuclease P activity
B4X03_RS00935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4X03_RS00940	COG1739	Uncharacterized protein family UPF0029
B4X03_RS00945	COG2358	TRAP transporter, solute receptor (TAXI family
B4X03_RS00995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4X03_RS01005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4X03_RS01010	COG0569	domain protein
B4X03_RS01015	COG0686	Belongs to the AlaDH PNT family
B4X03_RS01045	COG0070	glutamate synthase
B4X03_RS01045	COG0069	glutamate synthase activity
B4X03_RS01045	COG0067	glutamate synthase
B4X03_RS01050	COG0493	'glutamate synthase
B4X03_RS01060	COG1126	abc transporter atp-binding protein
B4X03_RS01065	COG0765	amino acid transport
B4X03_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4X03_RS01090	COG0204	Acyl-transferase
B4X03_RS01100	COG0545	Peptidyl-prolyl cis-trans isomerase
B4X03_RS01105	COG2271	Major facilitator Superfamily
B4X03_RS01110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4X03_RS01120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4X03_RS01125	COG0598	Magnesium transport protein CorA
B4X03_RS01135	COG3924	membrane
B4X03_RS01140	COG4145	pantothenate transmembrane transporter activity
B4X03_RS01145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B4X03_RS01160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4X03_RS01175	COG0697	spore germination
B4X03_RS01180	COG0697	spore germination
B4X03_RS01195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4X03_RS01200	COG1126	abc transporter atp-binding protein
B4X03_RS01210	COG0765	amino acid transport
B4X03_RS01220	COG2995	paraquat-inducible protein a
B4X03_RS01230	COG0354	folic acid binding
B4X03_RS01270	COG1204	response to ionizing radiation
B4X03_RS01290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4X03_RS01300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4X03_RS01330	COG0351	phosphomethylpyrimidine kinase
B4X03_RS01335	COG0352	thiamine-phosphate diphosphorylase activity
B4X03_RS01340	COG4804	nuclease activity
B4X03_RS01365	COG0789	Transcriptional regulator
B4X03_RS01410	COG3550	peptidyl-serine autophosphorylation
B4X03_RS01430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4X03_RS01465	COG0335	large ribosomal subunit rRNA binding
B4X03_RS01470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4X03_RS01480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4X03_RS01485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4X03_RS01495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4X03_RS01510	COG3700	Belongs to the class B bacterial acid phosphatase family
B4X03_RS01520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B4X03_RS01525	COG3172	ATPase kinase involved in NAD metabolism
B4X03_RS01530	COG2129	metallophosphoesterase
B4X03_RS01535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B4X03_RS01540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4X03_RS01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4X03_RS01585	COG3590	peptidase
B4X03_RS01605	COG0235	Class ii aldolase
B4X03_RS01610	COG3623	hexulose-6-phosphate isomerase
B4X03_RS01635	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4X03_RS01640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4X03_RS01660	COG1522	sequence-specific DNA binding
B4X03_RS01665	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B4X03_RS01670	COG3085	chromosome segregation
B4X03_RS01690	COG3590	peptidase
B4X03_RS01695	COG0826	peptidase U32
B4X03_RS01705	COG0795	lipopolysaccharide-transporting ATPase activity
B4X03_RS01710	COG0795	lipopolysaccharide-transporting ATPase activity
B4X03_RS01730	COG1519	Transferase
B4X03_RS01750	COG2091	lysine biosynthetic process via aminoadipic acid
B4X03_RS01760	COG0494	nUDIX hydrolase
B4X03_RS01770	COG4974	Belongs to the 'phage' integrase family
B4X03_RS01835	COG0210	DNA helicase
B4X03_RS01840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4X03_RS01845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4X03_RS01850	COG3171	Protein conserved in bacteria
B4X03_RS01865	COG0085	RNA polymerase activity
B4X03_RS01870	COG3276	selenocysteine insertion sequence binding
B4X03_RS01905	COG0758	DNA mediated transformation
B4X03_RS01910	COG4558	Periplasmic binding protein
B4X03_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4X03_RS01920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B4X03_RS01925	COG5295	Hep Hag repeat protein
B4X03_RS01930	COG3328	transposase activity
B4X03_RS01940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4X03_RS01955	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4X03_RS01960	COG2226	methyltransferase
B4X03_RS01965	COG2830	Protein of unknown function (DUF452)
B4X03_RS01975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4X03_RS01990	COG4804	nuclease activity
B4X03_RS01995	COG4545	Glutaredoxin-related protein
B4X03_RS02015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4X03_RS02020	COG2900	Belongs to the SlyX family
B4X03_RS02025	COG0545	Peptidyl-prolyl cis-trans isomerase
B4X03_RS02030	COG2964	Protein conserved in bacteria
B4X03_RS02035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B4X03_RS02040	COG2923	Belongs to the DsrF TusC family
B4X03_RS02045	COG2168	tRNA wobble position uridine thiolation
B4X03_RS02055	COG1129	ABC transporter
B4X03_RS02060	COG3718	enzyme involved in inositol metabolism
B4X03_RS02070	COG1879	ABC-type sugar transport system periplasmic component
B4X03_RS02075	COG1129	ABC transporter
B4X03_RS02080	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4X03_RS02085	COG0673	inositol 2-dehydrogenase activity
B4X03_RS02095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4X03_RS02100	COG0673	inositol 2-dehydrogenase activity
B4X03_RS02110	COG3962	Belongs to the TPP enzyme family
B4X03_RS02125	COG0235	Class ii aldolase
B4X03_RS02135	COG1070	Carbohydrate kinase
B4X03_RS02140	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
B4X03_RS02160	COG1349	DNA-binding transcription factor activity
B4X03_RS02165	COG0445	tRNA wobble uridine modification
B4X03_RS02175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B4X03_RS02185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4X03_RS02200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4X03_RS02205	COG0295	cytidine deaminase activity
B4X03_RS02210	COG0745	RESPONSE REGULATOR receiver
B4X03_RS02220	COG1045	serine acetyltransferase
B4X03_RS02230	COG0716	FMN binding
B4X03_RS02250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4X03_RS02275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4X03_RS02285	COG0019	diaminopimelate decarboxylase activity
B4X03_RS02290	COG0814	amino acid
B4X03_RS02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4X03_RS02310	COG1966	Carbon starvation protein
B4X03_RS02335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4X03_RS02355	COG0471	metal ion transport
B4X03_RS02355	COG0490	domain, Protein
B4X03_RS02380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4X03_RS02435	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4X03_RS02440	COG1879	ABC-type sugar transport system periplasmic component
B4X03_RS02445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4X03_RS02450	COG0174	glutamine synthetase
B4X03_RS02460	COG3111	PFAM Bacterial OB fold (BOF) protein
B4X03_RS02465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4X03_RS02470	COG2850	peptidyl-arginine hydroxylation
B4X03_RS02475	COG4285	Biotin-protein ligase, N terminal
B4X03_RS02480	COG1268	BioY protein
B4X03_RS02485	COG0561	phosphatase activity
B4X03_RS02490	COG1040	competence protein
B4X03_RS02495	COG0084	hydrolase, TatD family'
B4X03_RS02500	COG0557	exoribonuclease II activity
B4X03_RS02505	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B4X03_RS02510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4X03_RS02515	COG0592	DNA-directed DNA polymerase activity
B4X03_RS02520	COG0762	integral membrane protein
B4X03_RS02530	COG4137	Cytochrome C assembly protein
B4X03_RS02535	COG4536	flavin adenine dinucleotide binding
B4X03_RS02570	COG1694	Mazg nucleotide pyrophosphohydrolase
B4X03_RS02575	COG2610	gluconate transmembrane transporter activity
B4X03_RS02580	COG3265	gluconokinase activity
B4X03_RS02585	COG1609	Transcriptional regulator
B4X03_RS02590	COG3005	denitrification pathway
B4X03_RS02595	COG3043	anaerobic respiration
B4X03_RS02600	COG0348	domain, Protein
B4X03_RS02605	COG0437	4 iron, 4 sulfur cluster binding
B4X03_RS02615	COG3062	negative regulation of establishment of protein localization
B4X03_RS02620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B4X03_RS02625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4X03_RS02635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4X03_RS02640	COG3119	arylsulfatase activity
B4X03_RS02645	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4X03_RS02650	COG0730	response to heat
B4X03_RS02655	COG0583	DNA-binding transcription factor activity
B4X03_RS02660	COG1309	transcriptional regulator
B4X03_RS02665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4X03_RS02670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4X03_RS02675	COG3084	Protein conserved in bacteria
B4X03_RS02685	COG1414	Transcriptional regulator
B4X03_RS02695	COG2731	YhcH YjgK YiaL family protein
B4X03_RS02700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B4X03_RS02705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B4X03_RS02710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4X03_RS02735	COG3381	protein complex oligomerization
B4X03_RS02745	COG0791	NLP P60 protein
B4X03_RS02765	COG2259	Doxx family
B4X03_RS02775	COG2990	Protein conserved in bacteria
B4X03_RS02780	COG0525	valine-tRNA ligase activity
B4X03_RS02785	COG0863	Belongs to the N(4) N(6)-methyltransferase family
B4X03_RS02800	COG2153	protein acetylation
B4X03_RS02820	COG0159	tryptophan synthase activity
B4X03_RS02830	COG0135	phosphoribosylanthranilate isomerase activity
B4X03_RS02830	COG0134	indole-3-glycerol-phosphate synthase activity
B4X03_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
B4X03_RS02845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4X03_RS02855	COG2927	DNA polymerase III (CHI subunit)
B4X03_RS02860	COG1022	Amp-dependent synthetase and ligase
B4X03_RS02875	COG0051	transcription antitermination factor activity, RNA binding
B4X03_RS02900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4X03_RS02910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4X03_RS02965	COG0202	RNA polymerase activity
B4X03_RS02980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4X03_RS02990	COG0201	protein transport
B4X03_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4X03_RS03020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4X03_RS03025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4X03_RS03045	COG0339	signal peptide processing
B4X03_RS03050	COG0077	Prephenate dehydratase
B4X03_RS03050	COG1605	Chorismate mutase
B4X03_RS03065	COG0439	Biotin carboxylase
B4X03_RS03070	COG0511	ligase activity, forming carbon-carbon bonds
B4X03_RS03085	COG1253	flavin adenine dinucleotide binding
B4X03_RS03090	COG0560	Phosphoserine phosphatase
B4X03_RS03100	COG1399	metal-binding, possibly nucleic acid-binding protein
B4X03_RS03110	COG0416	fatty acid biosynthetic process
B4X03_RS03115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4X03_RS03120	COG0076	glutamate decarboxylase activity
B4X03_RS03125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4X03_RS03135	COG1561	YicC-like family, N-terminal region
B4X03_RS03140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4X03_RS03145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4X03_RS03145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4X03_RS03150	COG2832	Protein of unknown function (DUF454)
B4X03_RS03155	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4X03_RS03175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B4X03_RS03180	COG1194	a g-specific adenine glycosylase
B4X03_RS03205	COG0247	lactate metabolic process
B4X03_RS03215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4X03_RS03220	COG2271	Major facilitator Superfamily
B4X03_RS03225	COG0584	glycerophosphoryl diester phosphodiesterase
B4X03_RS03230	COG0564	pseudouridine synthase activity
B4X03_RS03235	COG0668	transmembrane transport
B4X03_RS03240	COG0501	Belongs to the peptidase M48B family
B4X03_RS03245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B4X03_RS03280	COG1846	Transcriptional regulator
B4X03_RS03300	COG0742	ribosomal rna small subunit methyltransferase
B4X03_RS03305	COG0552	protein localization to endoplasmic reticulum
B4X03_RS03310	COG2884	Cell division ATP-binding protein ftsE
B4X03_RS03315	COG2177	Part of the ABC transporter FtsEX involved in
B4X03_RS03340	COG0024	Methionine aminopeptidase
B4X03_RS03345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4X03_RS03415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4X03_RS03420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B4X03_RS03425	COG4232	protein-disulfide reductase activity
B4X03_RS03430	COG0300	oxidoreductase activity
B4X03_RS03470	COG2878	Part of a membrane complex involved in electron transport
B4X03_RS03475	COG4656	Part of a membrane complex involved in electron transport
B4X03_RS03500	COG1560	Kdo2-lipid A biosynthetic process
B4X03_RS03505	COG2226	methyltransferase
B4X03_RS03510	COG1252	NADH dehydrogenase
B4X03_RS03515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4X03_RS03520	COG0402	S-adenosylhomocysteine deaminase activity
B4X03_RS03525	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4X03_RS03530	COG1136	(ABC) transporter
B4X03_RS03535	COG0288	reversible hydration of carbon dioxide
B4X03_RS03540	COG4221	oxidoreductase activity
B4X03_RS03545	COG0754	glutathionylspermidine amidase activity
B4X03_RS03550	COG0754	glutathionylspermidine amidase activity
B4X03_RS03555	COG2252	PERMEase
B4X03_RS03570	COG0330	HflC and HflK could
B4X03_RS03580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4X03_RS03655	COG0277	FAD linked oxidase domain protein
B4X03_RS03700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4X03_RS03725	COG1879	ABC-type sugar transport system periplasmic component
B4X03_RS03730	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4X03_RS03735	COG1129	ABC transporter
B4X03_RS03740	COG1482	cell wall glycoprotein biosynthetic process
B4X03_RS03750	COG3716	PTS system mannose fructose sorbose family IID component
B4X03_RS03755	COG3715	PTS system
B4X03_RS03760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4X03_RS03760	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4X03_RS03770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B4X03_RS03775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4X03_RS03800	COG0606	chelatase, subunit chli
B4X03_RS03805	COG0470	DNA polymerase III
B4X03_RS03825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4X03_RS03855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B4X03_RS03860	COG1238	metal cluster binding
B4X03_RS03865	COG1388	LysM domain
B4X03_RS03865	COG4942	peptidase
B4X03_RS03870	COG4942	peptidase
B4X03_RS03870	COG1388	LysM domain
B4X03_RS03875	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4X03_RS03885	COG0561	phosphatase activity
B4X03_RS03895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4X03_RS03900	COG0733	neurotransmitter:sodium symporter activity
B4X03_RS03910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4X03_RS03915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4X03_RS03920	COG1121	(ABC) transporter
B4X03_RS03930	COG1162	GTPase activity
B4X03_RS03945	COG0560	Phosphoserine phosphatase
B4X03_RS03955	COG3301	Polysulphide reductase, NrfD
B4X03_RS03960	COG0437	4 iron, 4 sulfur cluster binding
B4X03_RS03965	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B4X03_RS03975	COG1178	ABC-type Fe3 transport system permease component
B4X03_RS03980	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4X03_RS03985	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4X03_RS03990	COG2871	sodium ion transport
B4X03_RS04000	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B4X03_RS04005	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B4X03_RS04010	COG1805	sodium ion transport
B4X03_RS04020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4X03_RS04020	COG0316	Belongs to the HesB IscA family
B4X03_RS04030	COG0537	adenosine 5'-monophosphoramidase activity
B4X03_RS04045	COG0477	Major facilitator Superfamily
B4X03_RS04055	COG2965	DNA replication, synthesis of RNA primer
B4X03_RS04070	COG0210	DNA helicase
B4X03_RS04075	COG1126	abc transporter atp-binding protein
B4X03_RS04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4X03_RS04085	COG4215	(ABC) transporter
B4X03_RS04090	COG4160	amino acid transport
B4X03_RS04115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4X03_RS04120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4X03_RS04125	COG0748	coenzyme F420 binding
B4X03_RS04130	COG3721	Heme iron utilization protein
B4X03_RS04140	COG1663	tetraacyldisaccharide 4'-kinase activity
B4X03_RS04145	COG2835	tetraacyldisaccharide 4'-kinase activity
B4X03_RS04150	COG1575	Belongs to the MenA family. Type 1 subfamily
B4X03_RS04155	COG1720	tRNA m6t6A37 methyltransferase activity
B4X03_RS04185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4X03_RS04200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4X03_RS04215	COG2814	Major facilitator Superfamily
B4X03_RS04230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4X03_RS04235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4X03_RS04235	COG1215	transferase activity, transferring glycosyl groups
B4X03_RS04240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B4X03_RS04250	COG0084	hydrolase, TatD family'
B4X03_RS04265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B4X03_RS04275	COG1555	photosystem II stabilization
B4X03_RS04290	COG0859	PFAM glycosyl transferase family 9
B4X03_RS04295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4X03_RS04300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4X03_RS04305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4X03_RS04310	COG0142	geranyltranstransferase activity
B4X03_RS04325	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4X03_RS04330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4X03_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
B4X03_RS04360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4X03_RS04370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4X03_RS04390	COG0512	Glutamine amidotransferase of anthranilate synthase
B4X03_RS04395	COG1322	Protein conserved in bacteria
B4X03_RS04405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4X03_RS04410	COG0641	radical SAM
B4X03_RS04425	COG2960	long-chain fatty acid transporting porin activity
B4X03_RS04460	COG0551	DNA topoisomerase type I activity
B4X03_RS04470	COG2137	regulation of response to DNA damage stimulus
B4X03_RS04480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4X03_RS04500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4X03_RS04510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4X03_RS04535	COG1121	(ABC) transporter
B4X03_RS04555	COG0037	tRNA processing
B4X03_RS04580	COG5433	transposase activity
B4X03_RS04585	COG0583	DNA-binding transcription factor activity
B4X03_RS04590	COG1011	Hydrolase
B4X03_RS04595	COG0583	DNA-binding transcription factor activity
B4X03_RS04605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4X03_RS04615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4X03_RS04620	COG1426	Protein conserved in bacteria
B4X03_RS04625	COG0616	signal peptide processing
B4X03_RS04635	COG3201	nicotinamide mononucleotide transporter
B4X03_RS04640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4X03_RS04645	COG4133	protoheme IX ABC transporter activity
B4X03_RS04650	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4X03_RS04655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4X03_RS04660	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4X03_RS04665	COG0471	metal ion transport
B4X03_RS04670	COG0126	phosphoglycerate kinase activity
B4X03_RS04675	COG0191	fructose-bisphosphate aldolase activity
B4X03_RS04680	COG4172	Belongs to the ABC transporter superfamily
B4X03_RS04685	COG0778	Nitroreductase
B4X03_RS04700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4X03_RS04725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4X03_RS04725	COG0517	IMP dehydrogenase activity
B4X03_RS04730	COG3063	Type IV pilus biogenesis stability protein PilW
B4X03_RS04740	COG2944	sequence-specific DNA binding
B4X03_RS04795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4X03_RS04805	COG0330	HflC and HflK could
B4X03_RS04810	COG0330	HflC and HflK could
B4X03_RS04815	COG0456	acetyltransferase
B4X03_RS04830	COG1120	ATPase activity
B4X03_RS04845	COG1538	Outer membrane efflux protein
B4X03_RS04850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4X03_RS04855	COG0346	lactoylglutathione lyase activity
B4X03_RS04865	COG2911	Protein conserved in bacteria
B4X03_RS04890	COG1476	TRANSCRIPTIONal
B4X03_RS04905	COG0280	phosphate acetyltransferase
B4X03_RS04905	COG0281	malic enzyme
B4X03_RS04910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4X03_RS04915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4X03_RS04935	COG0469	pyruvate kinase activity
B4X03_RS04940	COG2062	phosphohistidine phosphatase, SixA
B4X03_RS04950	COG2197	response regulator
B4X03_RS04960	COG2271	Major facilitator Superfamily
B4X03_RS04970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4X03_RS04980	COG0583	DNA-binding transcription factor activity
B4X03_RS04995	COG0500	methyltransferase
B4X03_RS05000	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B4X03_RS05015	COG0308	aminopeptidase N
B4X03_RS05025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B4X03_RS05030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B4X03_RS05035	COG0802	atpase or kinase
B4X03_RS05040	COG1388	LysM domain
B4X03_RS05040	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4X03_RS05050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B4X03_RS05055	COG1083	cytidylyl-transferase
B4X03_RS05070	COG3306	glycosyltransferase involved in LPS biosynthesis
B4X03_RS05080	COG1216	Glycosyl transferase, family 2
B4X03_RS05085	COG1216	Glycosyl transferase, family 2
B4X03_RS05090	COG1138	Cytochrome C-type biogenesis protein
B4X03_RS05100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B4X03_RS05105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B4X03_RS05110	COG1077	Cell shape determining protein MreB Mrl
B4X03_RS05115	COG1792	Involved in formation and maintenance of cell shape
B4X03_RS05120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4X03_RS05125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4X03_RS05130	COG4783	chaperone-mediated protein folding
B4X03_RS05155	COG4771	TonB-dependent receptor
B4X03_RS05155	COG1629	transport
B4X03_RS05160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4X03_RS05170	COG1560	Kdo2-lipid A biosynthetic process
B4X03_RS05175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4X03_RS05180	COG0393	Putative heavy-metal-binding
B4X03_RS05185	COG2983	Belongs to the UPF0260 family
B4X03_RS05190	COG0556	nucleotide-excision repair
B4X03_RS05200	COG4171	peptide transport system, permease
B4X03_RS05205	COG4172	Belongs to the ABC transporter superfamily
B4X03_RS05220	COG0187	DNA topoisomerase II activity
B4X03_RS05225	COG0753	catalase activity
B4X03_RS05230	COG1408	metallophosphoesterase
B4X03_RS05235	COG3120	sequence-specific DNA binding
B4X03_RS05240	COG1067	ATP-dependent peptidase activity
B4X03_RS05275	COG0534	Mate efflux family protein
B4X03_RS05280	COG0564	pseudouridine synthase activity
B4X03_RS05285	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4X03_RS05295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B4X03_RS05305	COG3639	organic phosphonate transmembrane transporter activity
B4X03_RS05310	COG3639	organic phosphonate transmembrane transporter activity
B4X03_RS05325	COG0730	response to heat
B4X03_RS05340	COG0716	FMN binding
B4X03_RS05345	COG0735	belongs to the Fur family
B4X03_RS05350	COG3008	intermembrane lipid transfer
B4X03_RS05365	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B4X03_RS05370	COG0793	Belongs to the peptidase S41A family
B4X03_RS05380	COG3108	Peptidase M15
B4X03_RS05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4X03_RS05390	COG2853	Lipoprotein
B4X03_RS05395	COG2932	Transcriptional regulator
B4X03_RS05405	COG0626	cystathionine gamma-synthase activity
B4X03_RS05415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4X03_RS05420	COG0538	isocitrate dehydrogenase activity
B4X03_RS05430	COG0372	Belongs to the citrate synthase family
B4X03_RS05435	COG0563	adenylate kinase activity
B4X03_RS05440	COG0733	neurotransmitter:sodium symporter activity
B4X03_RS05445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4X03_RS05450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4X03_RS05455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4X03_RS05460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B4X03_RS05485	COG4796	Type ii and iii secretion system protein
B4X03_RS05495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4X03_RS05500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4X03_RS05510	COG3118	belongs to the thioredoxin family
B4X03_RS05525	COG2050	protein possibly involved in aromatic compounds catabolism
B4X03_RS05530	COG0277	FAD linked oxidase domain protein
B4X03_RS05530	COG0247	lactate metabolic process
B4X03_RS05535	COG2885	chlorophyll binding
B4X03_RS05535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B4X03_RS05545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4X03_RS05550	COG4974	Belongs to the 'phage' integrase family
B4X03_RS05555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4X03_RS05575	COG1053	succinate dehydrogenase
B4X03_RS05580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4X03_RS05590	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B4X03_RS05620	COG1965	Belongs to the frataxin family
B4X03_RS05630	COG2259	Doxx family
B4X03_RS05640	COG3220	belongs to the UPF0276 family
B4X03_RS05645	COG3219	Protein conserved in bacteria
B4X03_RS05650	COG1595	DNA-templated transcription, initiation
B4X03_RS05665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4X03_RS05670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4X03_RS05675	COG1131	(ABC) transporter
B4X03_RS05680	COG0842	Transport permease protein
B4X03_RS05695	COG2925	Exonuclease
B4X03_RS05700	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
B4X03_RS05705	COG0613	PHP domain protein
B4X03_RS05710	COG0440	acetolactate synthase activity
B4X03_RS05715	COG0028	Belongs to the TPP enzyme family
B4X03_RS05730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4X03_RS05735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4X03_RS05745	COG0138	bifunctional purine biosynthesis protein purh
B4X03_RS05755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4X03_RS05765	COG3691	Protein conserved in bacteria
B4X03_RS05785	COG0647	UMP catabolic process
B4X03_RS05790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4X03_RS05805	COG1086	Polysaccharide biosynthesis protein
B4X03_RS05815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4X03_RS05825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4X03_RS05835	COG2030	dehydratase
B4X03_RS05840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4X03_RS05850	COG1596	polysaccharide export
B4X03_RS05865	COG1959	2 iron, 2 sulfur cluster binding
B4X03_RS05875	COG0822	iron-sulfur transferase activity
B4X03_RS05905	COG0633	Ferredoxin
B4X03_RS05910	COG2975	iron-sulfur cluster assembly
B4X03_RS05915	COG3328	transposase activity
B4X03_RS05920	COG1132	(ABC) transporter
B4X03_RS05930	COG1217	gtp-binding protein TYPA
B4X03_RS05935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4X03_RS05945	COG1271	oxidase subunit
B4X03_RS05950	COG1294	oxidase, subunit
B4X03_RS05965	COG0824	Thioesterase
B4X03_RS05970	COG0811	peptide transport
B4X03_RS05975	COG0848	biopolymer transport protein
B4X03_RS05980	COG3064	Membrane
B4X03_RS05980	COG3064	Membrane
B4X03_RS05985	COG0823	Involved in the tonB-independent uptake of proteins
B4X03_RS05995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B4X03_RS06005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4X03_RS06020	COG1530	ribonuclease E activity
B4X03_RS06025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4X03_RS06035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B4X03_RS06040	COG1137	ATPase activity
B4X03_RS06045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4X03_RS06055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4X03_RS06075	COG0747	negative chemotaxis
B4X03_RS06085	COG1120	ATPase activity
B4X03_RS06105	COG3112	Uncharacterised protein family (UPF0231)
B4X03_RS06130	COG0058	SHG alpha-glucan phosphorylase activity
B4X03_RS06135	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4X03_RS06140	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B4X03_RS06150	COG1477	protein flavinylation
B4X03_RS06155	COG2991	Protein conserved in bacteria
B4X03_RS06195	COG3116	cell division
B4X03_RS06200	COG0768	penicillin binding
B4X03_RS06205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4X03_RS06210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4X03_RS06220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4X03_RS06225	COG0772	Belongs to the SEDS family
B4X03_RS06250	COG0849	cell division
B4X03_RS06280	COG0681	Belongs to the peptidase S26 family
B4X03_RS06300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4X03_RS06305	COG2194	sulfuric ester hydrolase activity
B4X03_RS06310	COG0528	UMP kinase activity
B4X03_RS06325	COG1944	ATP diphosphatase activity
B4X03_RS06330	COG2252	PERMEase
B4X03_RS06335	COG0628	permease
B4X03_RS06340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4X03_RS06355	COG3978	acetolactate synthase activity
B4X03_RS06400	COG0494	nUDIX hydrolase
B4X03_RS06405	COG1238	metal cluster binding
B4X03_RS06410	COG2116	formate transmembrane transporter activity
B4X03_RS06415	COG1882	Formate acetyltransferase
B4X03_RS06420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B4X03_RS06425	COG2268	Band 7 protein
B4X03_RS06435	COG0786	glutamate:sodium symporter activity
B4X03_RS06440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4X03_RS06445	COG3105	Protein conserved in bacteria
B4X03_RS06470	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B4X03_RS06475	COG1840	ABC-type Fe3 transport system, periplasmic component
B4X03_RS06490	COG0305	Participates in initiation and elongation during chromosome replication
B4X03_RS06505	COG1509	lysine 2,3-aminomutase activity
B4X03_RS06525	COG3074	FtsZ-dependent cytokinesis
B4X03_RS06530	COG1435	thymidine kinase activity
B4X03_RS06535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4X03_RS06540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4X03_RS06540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4X03_RS06545	COG0670	Belongs to the BI1 family
B4X03_RS06550	COG0542	response to heat
B4X03_RS06555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4X03_RS06560	COG0739	heme binding
B4X03_RS06570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4X03_RS06575	COG0121	glutamine amidotransferase
B4X03_RS06580	COG3684	Belongs to the aldolase LacD family
B4X03_RS06595	COG3716	PTS system mannose fructose sorbose family IID component
B4X03_RS06605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4X03_RS06610	COG2222	sugar isomerase
B4X03_RS06615	COG1349	DNA-binding transcription factor activity
B4X03_RS06645	COG0195	Participates in both transcription termination and antitermination
B4X03_RS06650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4X03_RS06695	COG0583	DNA-binding transcription factor activity
B4X03_RS06705	COG3083	sulfuric ester hydrolase activity
B4X03_RS06715	COG3642	lipopolysaccharide core region biosynthetic process
B4X03_RS06720	COG0302	gtp cyclohydrolase
B4X03_RS06725	COG0301	tRNA thio-modification
B4X03_RS06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4X03_RS06735	COG3026	antisigma factor binding
B4X03_RS06745	COG0318	PFAM AMP-dependent synthetase and ligase
B4X03_RS06750	COG4942	peptidase
B4X03_RS06755	COG2861	carbohydrate metabolic process
B4X03_RS06760	COG0729	surface antigen
B4X03_RS06765	COG2911	Protein conserved in bacteria
B4X03_RS06775	COG4988	ABC transporter
B4X03_RS06780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4X03_RS06785	COG0494	nUDIX hydrolase
B4X03_RS06810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4X03_RS06815	COG0617	tRNA 3'-terminal CCA addition
B4X03_RS06820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4X03_RS06825	COG1640	4-alpha-glucanotransferase
B4X03_RS06830	COG3833	ABC-type maltose transport systems, permease component
B4X03_RS06835	COG1175	transmembrane transport
B4X03_RS06845	COG3842	ATPase activity
B4X03_RS06850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4X03_RS06870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4X03_RS06880	COG0189	ligase activity
B4X03_RS06890	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B4X03_RS06910	COG0617	tRNA 3'-terminal CCA addition
B4X03_RS06915	COG0778	Nitroreductase
B4X03_RS06920	COG3691	Protein conserved in bacteria
B4X03_RS06925	COG0527	aspartate kinase activity
B4X03_RS06935	COG3021	interspecies interaction between organisms
B4X03_RS06950	COG1494	fructose-1,6-bisphosphatase
B4X03_RS06955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4X03_RS06965	COG0561	phosphatase activity
B4X03_RS06975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4X03_RS06980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4X03_RS07015	COG0243	molybdopterin cofactor binding
B4X03_RS07015	COG3383	formate dehydrogenase (NAD+) activity
B4X03_RS07020	COG0243	molybdopterin cofactor binding
B4X03_RS07020	COG3383	formate dehydrogenase (NAD+) activity
B4X03_RS07025	COG0437	4 iron, 4 sulfur cluster binding
B4X03_RS07030	COG2864	formate dehydrogenase
B4X03_RS07035	COG2822	iron ion transport
B4X03_RS07050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4X03_RS07055	COG1523	belongs to the glycosyl hydrolase 13 family
B4X03_RS07060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4X03_RS07070	COG0517	IMP dehydrogenase activity
B4X03_RS07070	COG0516	GMP reductase activity
B4X03_RS07075	COG3955	Domain of unknown function (DUF1919)
B4X03_RS07110	COG1783	phage Terminase large subunit
B4X03_RS07130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4X03_RS07145	COG1598	PFAM Uncharacterised protein family UPF0150
B4X03_RS07150	COG1724	mRNA binding
B4X03_RS07165	COG3112	Uncharacterised protein family (UPF0231)
B4X03_RS07175	COG0708	Exodeoxyribonuclease III
B4X03_RS07180	COG2056	Na+-H+ antiporter family
B4X03_RS07185	COG0037	tRNA processing
B4X03_RS07210	COG1522	sequence-specific DNA binding
B4X03_RS07215	COG1674	ftsk spoiiie
B4X03_RS07220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B4X03_RS07225	COG1214	PFAM Peptidase M22, glycoprotease
B4X03_RS07240	COG3021	interspecies interaction between organisms
B4X03_RS07255	COG0187	DNA topoisomerase II activity
B4X03_RS07260	COG3945	hemerythrin HHE cation binding domain
B4X03_RS07265	COG0425	Belongs to the sulfur carrier protein TusA family
B4X03_RS07280	COG0312	modulator of DNA gyrase
B4X03_RS07310	COG2814	Major facilitator Superfamily
B4X03_RS07320	COG2205	protein histidine kinase activity
B4X03_RS07325	COG0745	RESPONSE REGULATOR receiver
B4X03_RS07330	COG3956	TIGRFAM MazG family protein
B4X03_RS07335	COG0006	proline dipeptidase activity
B4X03_RS07355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4X03_RS07360	COG0732	type I restriction modification DNA specificity domain
B4X03_RS07365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4X03_RS07380	COG0564	pseudouridine synthase activity
B4X03_RS07400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B4X03_RS07405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4X03_RS07410	COG1278	Cold shock
B4X03_RS07415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4X03_RS07420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4X03_RS07425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4X03_RS07430	COG0741	lytic transglycosylase activity
B4X03_RS07450	COG3112	Uncharacterised protein family (UPF0231)
B4X03_RS07455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4X03_RS07460	COG0629	single-stranded DNA binding
B4X03_RS07465	COG0433	COG0433 Predicted ATPase
B4X03_RS07470	COG0513	Belongs to the DEAD box helicase family
B4X03_RS07475	COG3093	addiction module antidote protein HigA
B4X03_RS07510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4X03_RS07520	COG0596	Alpha beta hydrolase
B4X03_RS07530	COG0318	PFAM AMP-dependent synthetase and ligase
B4X03_RS07535	COG3264	Mechanosensitive ion channel
B4X03_RS07535	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B4X03_RS07555	COG1846	Transcriptional regulator
B4X03_RS07555	COG1940	carbohydrate kinase activity
B4X03_RS07560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B4X03_RS07585	COG0857	belongs to the CobB CobQ family
B4X03_RS07585	COG0280	phosphate acetyltransferase
B4X03_RS07595	COG2969	positive regulation of protein catabolic process
B4X03_RS07600	COG0625	glutathione transferase activity
B4X03_RS07610	COG0285	dihydrofolate synthase activity
B4X03_RS07630	COG1448	Aminotransferase
B4X03_RS07645	COG2081	HI0933 family
B4X03_RS07655	COG1737	Transcriptional regulator
B4X03_RS07660	COG2731	YhcH YjgK YiaL family protein
B4X03_RS07680	COG0582	viral genome integration into host DNA
B4X03_RS07690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4X03_RS07710	COG2363	Small membrane protein
B4X03_RS07725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4X03_RS07730	COG0314	molybdopterin synthase activity
B4X03_RS07740	COG1444	tRNA N-acetyltransferase activity
B4X03_RS07745	COG1879	ABC-type sugar transport system periplasmic component
B4X03_RS07750	COG1129	ABC transporter
B4X03_RS07755	COG4211	Belongs to the binding-protein-dependent transport system permease family
B4X03_RS07775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4X03_RS07780	COG2095	MarC family integral membrane protein
B4X03_RS07785	COG4166	transmembrane transport
B4X03_RS07790	COG0489	protein tyrosine kinase activity
B4X03_RS07795	COG5295	Hep Hag repeat protein
B4X03_RS07815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4X03_RS07820	COG0023	Translation Initiation Factor
B4X03_RS07830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B4X03_RS07835	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
B4X03_RS07845	COG0539	negative regulation of cytoplasmic translation
B4X03_RS07850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4X03_RS07855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4X03_RS07860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4X03_RS07870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4X03_RS07875	COG0589	response to stress
B4X03_RS07880	COG0658	competence protein
B4X03_RS07880	COG2333	competence protein COMEC
B4X03_RS07890	COG2350	Protein conserved in bacteria
B4X03_RS07895	COG1607	acyl-coa hydrolase
B4X03_RS07910	COG3092	negative regulation of chromosome organization
B4X03_RS07915	COG0590	tRNA wobble adenosine to inosine editing
B4X03_RS07920	COG0513	Belongs to the DEAD box helicase family
B4X03_RS07925	COG4785	May be involved in cell division
B4X03_RS07945	COG4178	(ABC) transporter
B4X03_RS07960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4X03_RS07965	COG5002	protein histidine kinase activity
B4X03_RS07965	COG2198	Histidine kinase
B4X03_RS07965	COG0784	Response regulator, receiver
B4X03_RS07990	COG2949	membrane
B4X03_RS07995	COG0697	spore germination
B4X03_RS08005	COG3302	dmso reductase anchor subunit
B4X03_RS08010	COG2183	response to ionizing radiation
B4X03_RS08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4X03_RS08020	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4X03_RS08025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B4X03_RS08030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4X03_RS08040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4X03_RS08045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4X03_RS08065	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B4X03_RS08065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4X03_RS08085	COG0303	'Molybdopterin
B4X03_RS08090	COG2095	MarC family integral membrane protein
B4X03_RS08095	COG0488	(ABC) transporter
B4X03_RS08105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4X03_RS08115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4X03_RS08125	COG4735	regulation of single-species biofilm formation
B4X03_RS08145	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B4X03_RS08150	COG0586	Pfam SNARE associated Golgi protein
B4X03_RS08165	COG2840	Smr protein MutS2
B4X03_RS08170	COG0814	amino acid
B4X03_RS08175	COG0814	amino acid
B4X03_RS08205	COG2951	lytic endotransglycosylase activity
B4X03_RS08210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4X03_RS08230	COG0058	SHG alpha-glucan phosphorylase activity
B4X03_RS08240	COG0567	Dehydrogenase, E1 component
B4X03_RS08245	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4X03_RS08255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4X03_RS08260	COG0475	glutathione-regulated potassium exporter activity
B4X03_RS08260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4X03_RS08280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4X03_RS08285	COG0709	Synthesizes selenophosphate from selenide and ATP
B4X03_RS08290	COG3036	rescue of stalled ribosome
B4X03_RS08295	COG2226	methyltransferase
B4X03_RS08315	COG1368	sulfuric ester hydrolase activity
B4X03_RS08320	COG0633	Ferredoxin
B4X03_RS08320	COG3217	Mosc domain protein beta barrel domain protein
B4X03_RS08325	COG1722	exodeoxyribonuclease VII activity
B4X03_RS08330	COG0142	geranyltranstransferase activity
B4X03_RS08345	COG0183	Belongs to the thiolase family
B4X03_RS08350	COG1556	Lactate utilization protein
B4X03_RS08355	COG1139	Iron-sulfur cluster binding protein
B4X03_RS08360	COG0247	lactate metabolic process
B4X03_RS08365	COG1620	l-lactate permease
B4X03_RS08370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4X03_RS08375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4X03_RS08380	COG0730	response to heat
B4X03_RS08385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4X03_RS08395	COG4991	sh3 domain protein
B4X03_RS08400	COG0306	phosphate transporter
B4X03_RS08405	COG1392	Phosphate transport regulator
B4X03_RS08415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4X03_RS08415	COG0072	phenylalanine-tRNA ligase activity
B4X03_RS08425	COG0791	NLP P60 protein
B4X03_RS08445	COG1286	toxin biosynthetic process
B4X03_RS08450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4X03_RS08455	COG1496	oxidoreductase activity
B4X03_RS08460	COG0251	oxidation-reduction process
B4X03_RS08480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4X03_RS08495	COG3098	single-species biofilm formation
B4X03_RS08500	COG0564	pseudouridine synthase activity
B4X03_RS08515	COG2914	Belongs to the UPF0125 (RnfH) family
B4X03_RS08520	COG2867	negative regulation of translational initiation
B4X03_RS08545	COG3025	triphosphatase activity
B4X03_RS08550	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
B4X03_RS08555	COG1595	DNA-templated transcription, initiation
B4X03_RS08570	COG0732	type I restriction modification DNA specificity domain
B4X03_RS08585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B4X03_RS08610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4X03_RS08625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4X03_RS08625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B4X03_RS08630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4X03_RS08635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4X03_RS08650	COG5007	Belongs to the BolA IbaG family
B4X03_RS08660	COG2854	intermembrane phospholipid transfer
B4X03_RS08665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4X03_RS08670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4X03_RS08675	COG1127	ABC transporter
B4X03_RS08680	COG2823	Periplasmic or secreted lipoprotein
B4X03_RS08685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B4X03_RS08690	COG0792	nuclease activity
B4X03_RS08705	COG0783	Belongs to the Dps family
B4X03_RS08740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4X03_RS08745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4X03_RS08750	COG2032	superoxide dismutase activity
B4X03_RS08755	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4X03_RS08760	COG2364	Membrane
B4X03_RS08780	COG1349	DNA-binding transcription factor activity
B4X03_RS08810	COG3068	Protein conserved in bacteria
B4X03_RS08815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4X03_RS08820	COG0676	glucose-6-phosphate 1-epimerase activity
B4X03_RS08830	COG3842	ATPase activity
B4X03_RS08835	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4X03_RS08840	COG1177	transmembrane transport
B4X03_RS08850	COG2976	Protein conserved in bacteria
B4X03_RS08855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4X03_RS08860	COG2814	Major facilitator Superfamily
B4X03_RS08880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4X03_RS08885	COG4149	molybdate abc transporter
B4X03_RS08890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4X03_RS08910	COG2431	L-lysine efflux transmembrane transporter activity
B4X03_RS08915	COG3023	N-Acetylmuramoyl-L-alanine amidase
B4X03_RS08920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B4X03_RS08935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4X03_RS08945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4X03_RS08970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4X03_RS08980	COG3759	membrane
B4X03_RS08990	COG4804	nuclease activity
B4X03_RS08995	COG0363	glucosamine-6-phosphate deaminase activity
B4X03_RS09000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4X03_RS09005	COG1218	3'(2'),5'-bisphosphate nucleotidase
B4X03_RS09035	COG1216	Glycosyl transferase, family 2
B4X03_RS09040	COG1442	glycosyl transferase family 8
B4X03_RS09045	COG3306	glycosyltransferase involved in LPS biosynthesis
B4X03_RS09055	COG0583	DNA-binding transcription factor activity
B4X03_RS09065	COG1199	ATP-dependent helicase activity
B4X03_RS09080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4X03_RS09090	COG1025	Belongs to the peptidase M16 family
B4X03_RS09100	COG1115	amino acid carrier protein
B4X03_RS09105	COG0181	hydroxymethylbilane synthase activity
B4X03_RS09115	COG2959	enzyme of heme biosynthesis
B4X03_RS09120	COG3071	HemY protein
B4X03_RS09130	COG2909	trisaccharide binding
B4X03_RS09140	COG4172	Belongs to the ABC transporter superfamily
B4X03_RS09145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4X03_RS09150	COG0601	transmembrane transport
B4X03_RS09155	COG4166	transmembrane transport
B4X03_RS09160	COG2255	four-way junction helicase activity
B4X03_RS09165	COG0475	glutathione-regulated potassium exporter activity
B4X03_RS09165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4X03_RS09200	COG1534	Rna-binding protein
B4X03_RS09205	COG0463	Glycosyl transferase, family 2
B4X03_RS09210	COG0492	ferredoxin-NADP+ reductase activity
B4X03_RS09215	COG3118	belongs to the thioredoxin family
B4X03_RS09230	COG1090	epimerase
B4X03_RS09245	COG0859	PFAM glycosyl transferase family 9
B4X03_RS09255	COG0778	Nitroreductase
B4X03_RS09260	COG3101	peptidyl-lysine hydroxylation
B4X03_RS09285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B4X03_RS09290	COG1862	Preprotein translocase
B4X03_RS09295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4X03_RS09300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4X03_RS09340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4X03_RS09350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4X03_RS09355	COG2190	(PTS) system
B4X03_RS09360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4X03_RS09385	COG0495	leucyl-tRNA aminoacylation
B4X03_RS09390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B4X03_RS09395	COG1466	dna polymerase III delta subunit
B4X03_RS09400	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B4X03_RS09405	COG0237	dephospho-CoA kinase activity
B4X03_RS09410	COG1393	Belongs to the ArsC family
B4X03_RS09415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4X03_RS09435	COG0494	nUDIX hydrolase
B4X03_RS09455	COG4608	Belongs to the ABC transporter superfamily
B4X03_RS09460	COG0444	Belongs to the ABC transporter superfamily
B4X03_RS09465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4X03_RS09470	COG0601	transmembrane transport
B4X03_RS09475	COG0747	negative chemotaxis
B4X03_RS09480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4X03_RS09495	COG1678	Uncharacterized ACR, COG1678
B4X03_RS09500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4X03_RS09505	COG3056	Lipoprotein
B4X03_RS09510	COG0271	Belongs to the BolA IbaG family
B4X03_RS09520	COG0564	pseudouridine synthase activity
B4X03_RS09525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4X03_RS09550	COG1074	ATP-dependent DNA helicase activity
B4X03_RS09575	COG1876	peptidase activity
B4X03_RS09580	COG4172	Belongs to the ABC transporter superfamily
B4X03_RS09595	COG0747	negative chemotaxis
B4X03_RS09600	COG2005	Transcriptional regulator
B4X03_RS09605	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4X03_RS09655	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4X03_RS09660	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4X03_RS09665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B4X03_RS09670	COG0194	GDP metabolic process
B4X03_RS09675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4X03_RS09685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4X03_RS09690	COG1459	type II secretion system
B4X03_RS09705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4X03_RS09715	COG2166	iron-sulfur cluster assembly
B4X03_RS09725	COG0009	L-threonylcarbamoyladenylate synthase
B4X03_RS09730	COG1187	pseudouridine synthase activity
B4X03_RS09735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4X03_RS09755	COG0196	riboflavin kinase activity
B4X03_RS09775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4X03_RS09780	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B4X03_RS09795	COG0012	GTP binding
B4X03_RS09815	COG3630	sodium ion export across plasma membrane
B4X03_RS09820	COG5016	pyruvate
B4X03_RS09820	COG0511	ligase activity, forming carbon-carbon bonds
B4X03_RS09825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B4X03_RS09830	COG2824	Alkylphosphonate utilization operon protein PhnA
B4X03_RS09835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4X03_RS09840	COG1027	Aspartate ammonia-lyase
B4X03_RS09855	COG2027	D-alanyl-D-alanine carboxypeptidase
B4X03_RS09860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4X03_RS09870	COG2932	Transcriptional regulator
B4X03_RS09875	COG3423	Transcriptional regulator
B4X03_RS09890	COG2842	Transposition protein
B4X03_RS09905	COG4396	Host-nuclease inhibitor protein Gam
B4X03_RS09955	COG3023	N-Acetylmuramoyl-L-alanine amidase
B4X03_RS09990	COG4383	Mu-like prophage protein gp29
B4X03_RS09995	COG2369	cell adhesion
B4X03_RS10000	COG5005	Phage virion morphogenesis
B4X03_RS10010	COG4397	Mu-like prophage major head subunit gpT
B4X03_RS10110	COG3392	D12 class N6 adenine-specific DNA methyltransferase
B4X03_RS10125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4X03_RS10130	COG4608	Belongs to the ABC transporter superfamily
B4X03_RS10135	COG0444	Belongs to the ABC transporter superfamily
B4X03_RS10155	COG0788	formyltetrahydrofolate deformylase activity
B4X03_RS10165	COG1757	Na H antiporter
B4X03_RS10170	COG1138	Cytochrome C-type biogenesis protein
B4X03_RS10175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4X03_RS10180	COG3088	subunit of a heme lyase
B4X03_RS10180	COG4235	cytochrome complex assembly
B4X03_RS10185	COG4235	cytochrome complex assembly
B4X03_RS10185	COG3088	subunit of a heme lyase
B4X03_RS10190	COG3842	ATPase activity
B4X03_RS10200	COG1840	ABC-type Fe3 transport system, periplasmic component
B4X03_RS10205	COG1858	cytochrome C peroxidase
B4X03_RS10210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4X03_RS10220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4X03_RS10245	COG1122	ATPase activity
B4X03_RS10280	COG0582	viral genome integration into host DNA
B4X03_RS10385	COG1598	PFAM Uncharacterised protein family UPF0150
B4X03_RS10415	COG3772	lysozyme
B4X03_RS10430	COG3728	DNA packaging
B4X03_RS10435	COG1783	phage Terminase large subunit
B4X03_RS10525	COG3112	Uncharacterised protein family (UPF0231)
B4X03_RS10545	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B4X03_RS10550	COG1621	beta-fructofuranosidase activity
B4X03_RS10555	COG1396	sequence-specific DNA binding
B4X03_RS10570	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
B4X03_RS10585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4X03_RS10605	COG0018	arginyl-trna synthetase
B4X03_RS10610	COG3102	Protein conserved in bacteria
B4X03_RS10615	COG3133	Outer membrane lipoprotein
B4X03_RS10630	COG0024	Methionine aminopeptidase
B4X03_RS10635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4X03_RS10655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4X03_RS10660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4X03_RS10670	COG0131	Imidazoleglycerol-phosphate dehydratase
B4X03_RS10670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4X03_RS10690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4X03_RS10695	COG2258	MOSC domain
B4X03_RS10700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4X03_RS10705	COG0107	imidazoleglycerol-phosphate synthase activity
B4X03_RS10720	COG0140	phosphoribosyl-ATP diphosphatase activity
B4X03_RS10720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4X03_RS10745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4X03_RS10750	COG1957	nucleoside hydrolase
B4X03_RS10750	COG1957	nucleoside hydrolase
B4X03_RS10775	COG0546	phosphoglycolate phosphatase activity
B4X03_RS10780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4X03_RS10805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4X03_RS10815	COG4168	peptide transport system, permease
B4X03_RS10820	COG4166	transmembrane transport
B4X03_RS10835	COG0747	negative chemotaxis
B4X03_RS10845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4X03_RS10850	COG1530	ribonuclease E activity
B4X03_RS10865	COG1121	(ABC) transporter
B4X03_RS10870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4X03_RS10890	COG0251	oxidation-reduction process
B4X03_RS10895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4X03_RS10955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4X03_RS10960	COG0805	protein transport
B4X03_RS10985	COG0720	synthase
B4X03_RS10990	COG0602	queuosine metabolic process
B4X03_RS11000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4X03_RS11005	COG0488	(ABC) transporter
B4X03_RS11010	COG3468	outer membrane autotransporter barrel domain protein
B4X03_RS11045	COG0037	tRNA processing
B4X03_RS11050	COG3012	SEC-C Motif Domain Protein
B4X03_RS11065	COG2226	methyltransferase
B4X03_RS11075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4X03_RS11080	COG0616	signal peptide processing
B4X03_RS11090	COG0811	peptide transport
B4X03_RS11095	COG0848	biopolymer transport protein
B4X03_RS11100	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B4X03_RS11110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4X03_RS11115	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B4X03_RS11120	COG1380	Effector of murein hydrolase LrgA
B4X03_RS11125	COG0861	Integral membrane protein TerC family
B4X03_RS11155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4X03_RS11160	COG0785	Cytochrome C biogenesis protein