locus-tag	class	description
HAPS_RS00005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HAPS_RS00010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HAPS_RS00025	COG1053	succinate dehydrogenase
HAPS_RS00030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HAPS_RS00040	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HAPS_RS00065	COG1965	Belongs to the frataxin family
HAPS_RS00095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HAPS_RS00100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HAPS_RS00105	COG1131	(ABC) transporter
HAPS_RS00110	COG0842	Transport permease protein
HAPS_RS00125	COG2925	Exonuclease
HAPS_RS00130	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HAPS_RS00135	COG0613	PHP domain protein
HAPS_RS00140	COG0440	acetolactate synthase activity
HAPS_RS00145	COG0028	Belongs to the TPP enzyme family
HAPS_RS00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HAPS_RS00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HAPS_RS00165	COG1309	transcriptional regulator
HAPS_RS00175	COG0626	cystathionine gamma-synthase activity
HAPS_RS00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HAPS_RS00190	COG3691	Protein conserved in bacteria
HAPS_RS00200	COG1083	cytidylyl-transferase
HAPS_RS00205	COG2244	polysaccharide biosynthetic process
HAPS_RS00230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HAPS_RS00245	COG1596	polysaccharide export
HAPS_RS00260	COG1959	2 iron, 2 sulfur cluster binding
HAPS_RS00270	COG0822	iron-sulfur transferase activity
HAPS_RS00300	COG0633	Ferredoxin
HAPS_RS00305	COG2975	iron-sulfur cluster assembly
HAPS_RS00315	COG1132	(ABC) transporter
HAPS_RS00325	COG1217	gtp-binding protein TYPA
HAPS_RS00330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HAPS_RS00340	COG1271	oxidase subunit
HAPS_RS00345	COG1294	oxidase, subunit
HAPS_RS00355	COG0824	Thioesterase
HAPS_RS00360	COG0811	peptide transport
HAPS_RS00365	COG0848	biopolymer transport protein
HAPS_RS00370	COG3064	Membrane
HAPS_RS00370	COG3064	Membrane
HAPS_RS00375	COG0823	Involved in the tonB-independent uptake of proteins
HAPS_RS00385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HAPS_RS00395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HAPS_RS00410	COG1530	ribonuclease E activity
HAPS_RS00415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HAPS_RS00425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HAPS_RS00430	COG1137	ATPase activity
HAPS_RS00435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAPS_RS00445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HAPS_RS00465	COG0747	negative chemotaxis
HAPS_RS00470	COG1760	l-serine dehydratase
HAPS_RS00470	COG1760	l-serine dehydratase
HAPS_RS00490	COG0058	SHG alpha-glucan phosphorylase activity
HAPS_RS00495	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HAPS_RS00510	COG1477	protein flavinylation
HAPS_RS00515	COG2991	Protein conserved in bacteria
HAPS_RS00560	COG3116	cell division
HAPS_RS00565	COG0768	penicillin binding
HAPS_RS00570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HAPS_RS00575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HAPS_RS00585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HAPS_RS00590	COG0772	Belongs to the SEDS family
HAPS_RS00615	COG0849	cell division
HAPS_RS00650	COG0681	Belongs to the peptidase S26 family
HAPS_RS00670	COG1943	Transposase
HAPS_RS00675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HAPS_RS00685	COG0528	UMP kinase activity
HAPS_RS00705	COG2252	PERMEase
HAPS_RS00710	COG0628	permease
HAPS_RS00715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HAPS_RS00730	COG3978	acetolactate synthase activity
HAPS_RS00765	COG0494	nUDIX hydrolase
HAPS_RS00770	COG1238	metal cluster binding
HAPS_RS00775	COG2116	formate transmembrane transporter activity
HAPS_RS00780	COG1882	Formate acetyltransferase
HAPS_RS00785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HAPS_RS00790	COG2268	Band 7 protein
HAPS_RS00800	COG0786	glutamate:sodium symporter activity
HAPS_RS00805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HAPS_RS00810	COG3105	Protein conserved in bacteria
HAPS_RS00835	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HAPS_RS00840	COG1840	ABC-type Fe3 transport system, periplasmic component
HAPS_RS00855	COG0305	Participates in initiation and elongation during chromosome replication
HAPS_RS00870	COG1509	lysine 2,3-aminomutase activity
HAPS_RS00890	COG3074	FtsZ-dependent cytokinesis
HAPS_RS00895	COG1435	thymidine kinase activity
HAPS_RS00900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HAPS_RS00905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HAPS_RS00905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HAPS_RS00910	COG0670	Belongs to the BI1 family
HAPS_RS00915	COG0542	response to heat
HAPS_RS00920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HAPS_RS00925	COG0739	heme binding
HAPS_RS00930	COG1121	(ABC) transporter
HAPS_RS00935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HAPS_RS00940	COG0121	glutamine amidotransferase
HAPS_RS00945	COG3684	Belongs to the aldolase LacD family
HAPS_RS00960	COG3716	PTS system mannose fructose sorbose family IID component
HAPS_RS00970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HAPS_RS00975	COG2222	sugar isomerase
HAPS_RS00980	COG1349	DNA-binding transcription factor activity
HAPS_RS01010	COG0195	Participates in both transcription termination and antitermination
HAPS_RS01015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HAPS_RS01030	COG3293	Transposase
HAPS_RS01040	COG0583	DNA-binding transcription factor activity
HAPS_RS01045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HAPS_RS01050	COG3083	sulfuric ester hydrolase activity
HAPS_RS01060	COG3642	lipopolysaccharide core region biosynthetic process
HAPS_RS01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAPS_RS01070	COG0301	tRNA thio-modification
HAPS_RS01080	COG3026	antisigma factor binding
HAPS_RS01090	COG0318	PFAM AMP-dependent synthetase and ligase
HAPS_RS01095	COG4942	peptidase
HAPS_RS01100	COG2861	carbohydrate metabolic process
HAPS_RS01105	COG0729	surface antigen
HAPS_RS01110	COG2911	Protein conserved in bacteria
HAPS_RS01120	COG4988	ABC transporter
HAPS_RS01125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HAPS_RS01130	COG0494	nUDIX hydrolase
HAPS_RS01155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HAPS_RS01160	COG0617	tRNA 3'-terminal CCA addition
HAPS_RS01165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HAPS_RS01170	COG1640	4-alpha-glucanotransferase
HAPS_RS01175	COG3833	ABC-type maltose transport systems, permease component
HAPS_RS01190	COG3842	ATPase activity
HAPS_RS01195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HAPS_RS01250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HAPS_RS01255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HAPS_RS01260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HAPS_RS01270	COG1960	acyl-CoA dehydrogenase activity
HAPS_RS01280	COG0189	ligase activity
HAPS_RS01290	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HAPS_RS01310	COG0617	tRNA 3'-terminal CCA addition
HAPS_RS01315	COG0778	Nitroreductase
HAPS_RS01320	COG3691	Protein conserved in bacteria
HAPS_RS01335	COG3021	interspecies interaction between organisms
HAPS_RS01350	COG1494	fructose-1,6-bisphosphatase
HAPS_RS01355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HAPS_RS01365	COG0561	phosphatase activity
HAPS_RS01375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HAPS_RS01410	COG3383	formate dehydrogenase (NAD+) activity
HAPS_RS01410	COG0243	molybdopterin cofactor binding
HAPS_RS01415	COG0243	molybdopterin cofactor binding
HAPS_RS01415	COG3383	formate dehydrogenase (NAD+) activity
HAPS_RS01420	COG0437	4 iron, 4 sulfur cluster binding
HAPS_RS01425	COG2864	formate dehydrogenase
HAPS_RS01440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HAPS_RS01445	COG1523	belongs to the glycosyl hydrolase 13 family
HAPS_RS01450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HAPS_RS01460	COG0516	GMP reductase activity
HAPS_RS01460	COG0517	IMP dehydrogenase activity
HAPS_RS01465	COG3955	Domain of unknown function (DUF1919)
HAPS_RS01525	COG4735	regulation of single-species biofilm formation
HAPS_RS01550	COG0708	Exodeoxyribonuclease III
HAPS_RS01555	COG2056	Na+-H+ antiporter family
HAPS_RS01560	COG0037	tRNA processing
HAPS_RS01585	COG1522	sequence-specific DNA binding
HAPS_RS01590	COG1674	ftsk spoiiie
HAPS_RS01595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HAPS_RS01600	COG1214	PFAM Peptidase M22, glycoprotease
HAPS_RS01615	COG3021	interspecies interaction between organisms
HAPS_RS01630	COG0187	DNA topoisomerase II activity
HAPS_RS01635	COG3945	hemerythrin HHE cation binding domain
HAPS_RS01640	COG0425	Belongs to the sulfur carrier protein TusA family
HAPS_RS01655	COG0312	modulator of DNA gyrase
HAPS_RS01675	COG2814	Major facilitator Superfamily
HAPS_RS01685	COG2205	protein histidine kinase activity
HAPS_RS01690	COG0745	RESPONSE REGULATOR receiver
HAPS_RS01695	COG3956	TIGRFAM MazG family protein
HAPS_RS01700	COG0006	proline dipeptidase activity
HAPS_RS01725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HAPS_RS01735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HAPS_RS01750	COG0564	pseudouridine synthase activity
HAPS_RS01770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HAPS_RS01775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HAPS_RS01780	COG1278	Cold shock
HAPS_RS01785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HAPS_RS01790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HAPS_RS01795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HAPS_RS01800	COG0741	lytic transglycosylase activity
HAPS_RS01820	COG1441	menaquinone biosynthetic process
HAPS_RS01835	COG3112	Uncharacterised protein family (UPF0231)
HAPS_RS01840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HAPS_RS01845	COG0629	single-stranded DNA binding
HAPS_RS01850	COG1373	ATPase (AAA superfamily
HAPS_RS01860	COG0513	Belongs to the DEAD box helicase family
HAPS_RS01865	COG3093	addiction module antidote protein HigA
HAPS_RS01890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HAPS_RS01900	COG0596	Alpha beta hydrolase
HAPS_RS01910	COG0318	PFAM AMP-dependent synthetase and ligase
HAPS_RS01915	COG3264	Mechanosensitive ion channel
HAPS_RS01915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HAPS_RS01935	COG1940	carbohydrate kinase activity
HAPS_RS01935	COG1846	Transcriptional regulator
HAPS_RS01940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HAPS_RS01950	COG0280	phosphate acetyltransferase
HAPS_RS01950	COG0857	belongs to the CobB CobQ family
HAPS_RS01960	COG2969	positive regulation of protein catabolic process
HAPS_RS01965	COG0625	glutathione transferase activity
HAPS_RS01975	COG0285	dihydrofolate synthase activity
HAPS_RS01995	COG1448	Aminotransferase
HAPS_RS02000	COG0697	spore germination
HAPS_RS02005	COG2081	HI0933 family
HAPS_RS02015	COG1737	Transcriptional regulator
HAPS_RS02020	COG2731	YhcH YjgK YiaL family protein
HAPS_RS02085	COG2369	cell adhesion
HAPS_RS02095	COG3328	transposase activity
HAPS_RS02100	COG0582	viral genome integration into host DNA
HAPS_RS02110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HAPS_RS02120	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HAPS_RS02130	COG2363	Small membrane protein
HAPS_RS02160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HAPS_RS02165	COG0314	molybdopterin synthase activity
HAPS_RS02175	COG1444	tRNA N-acetyltransferase activity
HAPS_RS02180	COG1879	ABC-type sugar transport system periplasmic component
HAPS_RS02185	COG1129	ABC transporter
HAPS_RS02190	COG4211	Belongs to the binding-protein-dependent transport system permease family
HAPS_RS02210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HAPS_RS02215	COG2095	MarC family integral membrane protein
HAPS_RS02220	COG4166	transmembrane transport
HAPS_RS02225	COG0489	protein tyrosine kinase activity
HAPS_RS02240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HAPS_RS02245	COG0023	Translation Initiation Factor
HAPS_RS02255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HAPS_RS02260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HAPS_RS02270	COG0539	negative regulation of cytoplasmic translation
HAPS_RS02275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HAPS_RS02280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAPS_RS02285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HAPS_RS02295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HAPS_RS02300	COG0589	response to stress
HAPS_RS02305	COG2333	competence protein COMEC
HAPS_RS02305	COG0658	competence protein
HAPS_RS02310	COG2350	Protein conserved in bacteria
HAPS_RS02315	COG1607	acyl-coa hydrolase
HAPS_RS02330	COG3092	negative regulation of chromosome organization
HAPS_RS02335	COG0590	tRNA wobble adenosine to inosine editing
HAPS_RS02340	COG0513	Belongs to the DEAD box helicase family
HAPS_RS02345	COG4785	May be involved in cell division
HAPS_RS02370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HAPS_RS02375	COG5002	protein histidine kinase activity
HAPS_RS02375	COG2198	Histidine kinase
HAPS_RS02375	COG0784	Response regulator, receiver
HAPS_RS02400	COG2949	membrane
HAPS_RS02405	COG0697	spore germination
HAPS_RS02410	COG0437	4 iron, 4 sulfur cluster binding
HAPS_RS02415	COG3302	dmso reductase anchor subunit
HAPS_RS02420	COG2183	response to ionizing radiation
HAPS_RS02425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HAPS_RS02430	COG0508	dehydrogenase complex catalyzes the overall conversion of
HAPS_RS02435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HAPS_RS02440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HAPS_RS02450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HAPS_RS02455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HAPS_RS02475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HAPS_RS02475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HAPS_RS02495	COG0303	'Molybdopterin
HAPS_RS02505	COG2095	MarC family integral membrane protein
HAPS_RS02520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAPS_RS02530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HAPS_RS02555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HAPS_RS02575	COG0586	Pfam SNARE associated Golgi protein
HAPS_RS02590	COG2840	Smr protein MutS2
HAPS_RS02595	COG0814	amino acid
HAPS_RS02600	COG0814	amino acid
HAPS_RS02610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAPS_RS02615	COG0785	Cytochrome C biogenesis protein
HAPS_RS02620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAPS_RS02620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAPS_RS02630	COG1595	DNA-templated transcription, initiation
HAPS_RS02795	COG1724	mRNA binding
HAPS_RS02800	COG1598	PFAM Uncharacterised protein family UPF0150
HAPS_RS02825	COG0631	protein serine/threonine phosphatase activity
HAPS_RS02845	COG3723	Recombinational DNA repair protein, rece pathway
HAPS_RS02855	COG0629	single-stranded DNA binding
HAPS_RS02945	COG3077	Addiction module antitoxin, RelB DinJ family
HAPS_RS02985	COG0740	serine-type endopeptidase activity
HAPS_RS03020	COG3772	lysozyme
HAPS_RS03095	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HAPS_RS03160	COG2951	lytic endotransglycosylase activity
HAPS_RS03165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HAPS_RS03185	COG0058	SHG alpha-glucan phosphorylase activity
HAPS_RS03195	COG0567	Dehydrogenase, E1 component
HAPS_RS03200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HAPS_RS03210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HAPS_RS03215	COG0475	glutathione-regulated potassium exporter activity
HAPS_RS03215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HAPS_RS03225	COG2852	Protein conserved in bacteria
HAPS_RS03235	COG3106	COG3106 Predicted ATPase
HAPS_RS03240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HAPS_RS03245	COG0709	Synthesizes selenophosphate from selenide and ATP
HAPS_RS03250	COG3036	rescue of stalled ribosome
HAPS_RS03255	COG2226	methyltransferase
HAPS_RS03275	COG1368	sulfuric ester hydrolase activity
HAPS_RS03280	COG0633	Ferredoxin
HAPS_RS03280	COG3217	Mosc domain protein beta barrel domain protein
HAPS_RS03290	COG0142	geranyltranstransferase activity
HAPS_RS03305	COG0183	Belongs to the thiolase family
HAPS_RS03310	COG1556	Lactate utilization protein
HAPS_RS03315	COG1139	Iron-sulfur cluster binding protein
HAPS_RS03320	COG0247	lactate metabolic process
HAPS_RS03325	COG1620	l-lactate permease
HAPS_RS03330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HAPS_RS03335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HAPS_RS03340	COG0730	response to heat
HAPS_RS03345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HAPS_RS03355	COG4991	sh3 domain protein
HAPS_RS03360	COG0306	phosphate transporter
HAPS_RS03365	COG1392	Phosphate transport regulator
HAPS_RS03375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HAPS_RS03375	COG0072	phenylalanine-tRNA ligase activity
HAPS_RS03385	COG0791	NLP P60 protein
HAPS_RS03400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HAPS_RS03405	COG1286	toxin biosynthetic process
HAPS_RS03410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HAPS_RS03415	COG1496	oxidoreductase activity
HAPS_RS03420	COG0251	oxidation-reduction process
HAPS_RS03440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HAPS_RS03455	COG3098	single-species biofilm formation
HAPS_RS03460	COG0564	pseudouridine synthase activity
HAPS_RS03470	COG2914	Belongs to the UPF0125 (RnfH) family
HAPS_RS03475	COG2867	negative regulation of translational initiation
HAPS_RS03500	COG3025	triphosphatase activity
HAPS_RS03505	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HAPS_RS03510	COG1595	DNA-templated transcription, initiation
HAPS_RS03520	COG0732	type I restriction modification DNA specificity domain
HAPS_RS03530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HAPS_RS03565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HAPS_RS03580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HAPS_RS03580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HAPS_RS03585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HAPS_RS03590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HAPS_RS03605	COG5007	Belongs to the BolA IbaG family
HAPS_RS03615	COG2854	intermembrane phospholipid transfer
HAPS_RS03620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HAPS_RS03625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HAPS_RS03630	COG1127	ABC transporter
HAPS_RS03635	COG2823	Periplasmic or secreted lipoprotein
HAPS_RS03640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HAPS_RS03645	COG0792	nuclease activity
HAPS_RS03660	COG0783	Belongs to the Dps family
HAPS_RS03675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HAPS_RS03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAPS_RS03685	COG2032	superoxide dismutase activity
HAPS_RS03690	COG4591	ABC-type transport system involved in lipoprotein release permease component
HAPS_RS03695	COG2364	Membrane
HAPS_RS03720	COG0012	GTP binding
HAPS_RS03780	COG3728	DNA packaging
HAPS_RS03815	COG0582	viral genome integration into host DNA
HAPS_RS03830	COG1349	DNA-binding transcription factor activity
HAPS_RS03870	COG3068	Protein conserved in bacteria
HAPS_RS03875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HAPS_RS03880	COG0676	glucose-6-phosphate 1-epimerase activity
HAPS_RS03890	COG3842	ATPase activity
HAPS_RS03895	COG1176	ABC-type spermidine putrescine transport system, permease component I
HAPS_RS03900	COG1177	transmembrane transport
HAPS_RS03910	COG2976	Protein conserved in bacteria
HAPS_RS03915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HAPS_RS03920	COG2814	Major facilitator Superfamily
HAPS_RS03930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HAPS_RS03935	COG3023	N-Acetylmuramoyl-L-alanine amidase
HAPS_RS03940	COG2431	L-lysine efflux transmembrane transporter activity
HAPS_RS03960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HAPS_RS03965	COG4149	molybdate abc transporter
HAPS_RS03970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HAPS_RS04010	COG1476	TRANSCRIPTIONal
HAPS_RS04015	COG0582	viral genome integration into host DNA
HAPS_RS04040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HAPS_RS04065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HAPS_RS04070	COG1943	Transposase
HAPS_RS04075	COG3759	membrane
HAPS_RS04080	COG4804	nuclease activity
HAPS_RS04085	COG0363	glucosamine-6-phosphate deaminase activity
HAPS_RS04090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HAPS_RS04095	COG1218	3'(2'),5'-bisphosphate nucleotidase
HAPS_RS04120	COG1555	photosystem II stabilization
HAPS_RS04125	COG3266	domain, Protein
HAPS_RS04125	COG3061	Opacity-associated protein A
HAPS_RS04135	COG0859	PFAM glycosyl transferase family 9
HAPS_RS04140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HAPS_RS04145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAPS_RS04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAPS_RS04155	COG0142	geranyltranstransferase activity
HAPS_RS04160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HAPS_RS04165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HAPS_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
HAPS_RS04195	COG4382	Mu-like prophage protein Gp16
HAPS_RS04205	COG4396	Host-nuclease inhibitor protein Gam
HAPS_RS04215	COG3267	Type II secretory pathway component ExeA
HAPS_RS04215	COG3409	Peptidoglycan-binding domain 1 protein
HAPS_RS04285	COG0640	Transcriptional regulator
HAPS_RS04440	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HAPS_RS04445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HAPS_RS04465	COG0196	riboflavin kinase activity
HAPS_RS04495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HAPS_RS04500	COG0564	pseudouridine synthase activity
HAPS_RS04510	COG0271	Belongs to the BolA IbaG family
HAPS_RS04515	COG3056	Lipoprotein
HAPS_RS04520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HAPS_RS04525	COG1678	Uncharacterized ACR, COG1678
HAPS_RS04545	COG0747	negative chemotaxis
HAPS_RS04550	COG0601	transmembrane transport
HAPS_RS04555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAPS_RS04560	COG0444	Belongs to the ABC transporter superfamily
HAPS_RS04565	COG4608	Belongs to the ABC transporter superfamily
HAPS_RS04585	COG0494	nUDIX hydrolase
HAPS_RS04595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HAPS_RS04600	COG1393	Belongs to the ArsC family
HAPS_RS04605	COG0237	dephospho-CoA kinase activity
HAPS_RS04610	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HAPS_RS04615	COG1466	dna polymerase III delta subunit
HAPS_RS04620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HAPS_RS04625	COG0495	leucyl-tRNA aminoacylation
HAPS_RS04650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HAPS_RS04655	COG2190	(PTS) system
HAPS_RS04660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAPS_RS04670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HAPS_RS04695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HAPS_RS04700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HAPS_RS04705	COG1862	Preprotein translocase
HAPS_RS04710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HAPS_RS04730	COG3101	peptidyl-lysine hydroxylation
HAPS_RS04735	COG0778	Nitroreductase
HAPS_RS04745	COG0859	PFAM glycosyl transferase family 9
HAPS_RS04760	COG1090	epimerase
HAPS_RS04775	COG3118	belongs to the thioredoxin family
HAPS_RS04780	COG0492	ferredoxin-NADP+ reductase activity
HAPS_RS04785	COG0463	Glycosyl transferase, family 2
HAPS_RS04790	COG1534	Rna-binding protein
HAPS_RS04835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HAPS_RS04835	COG0475	glutathione-regulated potassium exporter activity
HAPS_RS04840	COG2255	four-way junction helicase activity
HAPS_RS04845	COG4166	transmembrane transport
HAPS_RS04850	COG0601	transmembrane transport
HAPS_RS04855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAPS_RS04860	COG4172	Belongs to the ABC transporter superfamily
HAPS_RS04865	COG0488	(ABC) transporter
HAPS_RS04870	COG2909	trisaccharide binding
HAPS_RS04880	COG3071	HemY protein
HAPS_RS04885	COG2959	enzyme of heme biosynthesis
HAPS_RS04895	COG0181	hydroxymethylbilane synthase activity
HAPS_RS04900	COG1115	amino acid carrier protein
HAPS_RS04910	COG1025	Belongs to the peptidase M16 family
HAPS_RS04920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HAPS_RS04935	COG1199	ATP-dependent helicase activity
HAPS_RS04945	COG0583	DNA-binding transcription factor activity
HAPS_RS04950	COG0859	PFAM glycosyl transferase family 9
HAPS_RS04960	COG3306	glycosyltransferase involved in LPS biosynthesis
HAPS_RS04995	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HAPS_RS05000	COG0084	hydrolase, TatD family'
HAPS_RS05010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HAPS_RS05015	COG1215	transferase activity, transferring glycosyl groups
HAPS_RS05020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HAPS_RS05035	COG2814	Major facilitator Superfamily
HAPS_RS05065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HAPS_RS05095	COG1720	tRNA m6t6A37 methyltransferase activity
HAPS_RS05100	COG1575	Belongs to the MenA family. Type 1 subfamily
HAPS_RS05110	COG1663	tetraacyldisaccharide 4'-kinase activity
HAPS_RS05120	COG3721	Heme iron utilization protein
HAPS_RS05125	COG0748	coenzyme F420 binding
HAPS_RS05130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HAPS_RS05155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HAPS_RS05160	COG4160	amino acid transport
HAPS_RS05165	COG4215	(ABC) transporter
HAPS_RS05170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAPS_RS05175	COG1126	abc transporter atp-binding protein
HAPS_RS05180	COG0210	DNA helicase
HAPS_RS05195	COG2965	DNA replication, synthesis of RNA primer
HAPS_RS05205	COG0477	Major facilitator Superfamily
HAPS_RS05220	COG0537	adenosine 5'-monophosphoramidase activity
HAPS_RS05230	COG0316	Belongs to the HesB IscA family
HAPS_RS05230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HAPS_RS05240	COG1805	sodium ion transport
HAPS_RS05245	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HAPS_RS05250	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HAPS_RS05260	COG2871	sodium ion transport
HAPS_RS05265	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HAPS_RS05270	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HAPS_RS05275	COG1178	ABC-type Fe3 transport system permease component
HAPS_RS05285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HAPS_RS05290	COG0437	4 iron, 4 sulfur cluster binding
HAPS_RS05295	COG3301	Polysulphide reductase, NrfD
HAPS_RS05305	COG0560	Phosphoserine phosphatase
HAPS_RS05320	COG1162	GTPase activity
HAPS_RS05330	COG1121	(ABC) transporter
HAPS_RS05335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HAPS_RS05340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HAPS_RS05345	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HAPS_RS05360	COG1396	sequence-specific DNA binding
HAPS_RS05365	COG1621	beta-fructofuranosidase activity
HAPS_RS05370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HAPS_RS05375	COG2824	Alkylphosphonate utilization operon protein PhnA
HAPS_RS05380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HAPS_RS05385	COG1027	Aspartate ammonia-lyase
HAPS_RS05400	COG2027	D-alanyl-D-alanine carboxypeptidase
HAPS_RS05405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HAPS_RS05410	COG3328	transposase activity
HAPS_RS05425	COG4608	Belongs to the ABC transporter superfamily
HAPS_RS05430	COG0444	Belongs to the ABC transporter superfamily
HAPS_RS05450	COG0788	formyltetrahydrofolate deformylase activity
HAPS_RS05460	COG1757	Na H antiporter
HAPS_RS05465	COG1138	Cytochrome C-type biogenesis protein
HAPS_RS05475	COG4235	cytochrome complex assembly
HAPS_RS05475	COG3088	subunit of a heme lyase
HAPS_RS05480	COG3088	subunit of a heme lyase
HAPS_RS05480	COG4235	cytochrome complex assembly
HAPS_RS05485	COG3842	ATPase activity
HAPS_RS05495	COG1840	ABC-type Fe3 transport system, periplasmic component
HAPS_RS05500	COG1858	cytochrome C peroxidase
HAPS_RS05505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HAPS_RS05515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HAPS_RS05540	COG1122	ATPase activity
HAPS_RS05575	COG0582	viral genome integration into host DNA
HAPS_RS05660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HAPS_RS05665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HAPS_RS05685	COG0512	Glutamine amidotransferase of anthranilate synthase
HAPS_RS05690	COG1322	Protein conserved in bacteria
HAPS_RS05700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HAPS_RS05705	COG0641	radical SAM
HAPS_RS05720	COG2960	long-chain fatty acid transporting porin activity
HAPS_RS05750	COG0009	L-threonylcarbamoyladenylate synthase
HAPS_RS05755	COG0551	DNA topoisomerase type I activity
HAPS_RS05765	COG2137	regulation of response to DNA damage stimulus
HAPS_RS05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HAPS_RS05795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HAPS_RS05805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HAPS_RS05825	COG1530	ribonuclease E activity
HAPS_RS05830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HAPS_RS05840	COG0747	negative chemotaxis
HAPS_RS05855	COG4166	transmembrane transport
HAPS_RS05860	COG4168	peptide transport system, permease
HAPS_RS05870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAPS_RS05895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HAPS_RS05900	COG0546	phosphoglycolate phosphatase activity
HAPS_RS05920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAPS_RS05920	COG1522	sequence-specific DNA binding
HAPS_RS05925	COG1957	nucleoside hydrolase
HAPS_RS05925	COG1957	nucleoside hydrolase
HAPS_RS05930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HAPS_RS05950	COG3102	Protein conserved in bacteria
HAPS_RS05955	COG0018	arginyl-trna synthetase
HAPS_RS05965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAPS_RS06005	COG0321	lipoyl(octanoyl) transferase activity
HAPS_RS06015	COG1686	Belongs to the peptidase S11 family
HAPS_RS06025	COG0772	Belongs to the SEDS family
HAPS_RS06030	COG0768	penicillin binding
HAPS_RS06035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HAPS_RS06040	COG0799	negative regulation of ribosome biogenesis
HAPS_RS06060	COG1263	PTS System
HAPS_RS06060	COG2190	(PTS) system
HAPS_RS06060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HAPS_RS06080	COG0596	Alpha beta hydrolase
HAPS_RS06090	COG1702	phosphate starvation-inducible protein PhoH
HAPS_RS06095	COG4143	(ABC) transporter
HAPS_RS06100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HAPS_RS06115	COG0436	Aminotransferase
HAPS_RS06120	COG1169	isochorismate synthase
HAPS_RS06125	COG0671	phosphoesterase, PA-phosphatase related
HAPS_RS06130	COG1940	carbohydrate kinase activity
HAPS_RS06145	COG0575	Belongs to the CDS family
HAPS_RS06150	COG0750	zinc metalloprotease
HAPS_RS06165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HAPS_RS06170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HAPS_RS06180	COG0460	homoserine dehydrogenase
HAPS_RS06180	COG0527	aspartate kinase activity
HAPS_RS06185	COG0083	homoserine kinase activity
HAPS_RS06190	COG1605	Chorismate mutase
HAPS_RS06190	COG0287	Prephenate dehydrogenase
HAPS_RS06195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HAPS_RS06200	COG0859	PFAM glycosyl transferase family 9
HAPS_RS06215	COG1115	amino acid carrier protein
HAPS_RS06220	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HAPS_RS06225	COG3683	transport system, periplasmic component
HAPS_RS06230	COG0339	signal peptide processing
HAPS_RS06235	COG0077	Prephenate dehydratase
HAPS_RS06235	COG1605	Chorismate mutase
HAPS_RS06250	COG0439	Biotin carboxylase
HAPS_RS06255	COG0511	ligase activity, forming carbon-carbon bonds
HAPS_RS06275	COG1399	metal-binding, possibly nucleic acid-binding protein
HAPS_RS06285	COG0416	fatty acid biosynthetic process
HAPS_RS06290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HAPS_RS06295	COG0076	glutamate decarboxylase activity
HAPS_RS06300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HAPS_RS06310	COG1561	YicC-like family, N-terminal region
HAPS_RS06315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HAPS_RS06320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HAPS_RS06320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HAPS_RS06325	COG2832	Protein of unknown function (DUF454)
HAPS_RS06330	COG0521	Mo-molybdopterin cofactor biosynthetic process
HAPS_RS06340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HAPS_RS06350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HAPS_RS06355	COG1194	a g-specific adenine glycosylase
HAPS_RS06380	COG0247	lactate metabolic process
HAPS_RS06390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HAPS_RS06400	COG0564	pseudouridine synthase activity
HAPS_RS06405	COG0668	transmembrane transport
HAPS_RS06410	COG0501	Belongs to the peptidase M48B family
HAPS_RS06415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HAPS_RS06420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HAPS_RS06495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HAPS_RS06510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HAPS_RS06515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HAPS_RS06520	COG1584	GPR1 FUN34 yaaH family protein
HAPS_RS06535	COG3719	Belongs to the RNase T2 family
HAPS_RS06540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HAPS_RS06545	COG0728	peptidoglycan biosynthetic process
HAPS_RS06565	COG0497	DNA recombination
HAPS_RS06585	COG0861	Integral membrane protein TerC family
HAPS_RS06590	COG1380	Effector of murein hydrolase LrgA
HAPS_RS06595	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HAPS_RS06600	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HAPS_RS06610	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HAPS_RS06615	COG0848	biopolymer transport protein
HAPS_RS06620	COG0811	peptide transport
HAPS_RS06630	COG0616	signal peptide processing
HAPS_RS06635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HAPS_RS06645	COG2226	methyltransferase
HAPS_RS06665	COG0037	tRNA processing
HAPS_RS06680	COG3468	outer membrane autotransporter barrel domain protein
HAPS_RS06695	COG3468	outer membrane autotransporter barrel domain protein
HAPS_RS06700	COG0488	(ABC) transporter
HAPS_RS06705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HAPS_RS06715	COG0602	queuosine metabolic process
HAPS_RS06720	COG0720	synthase
HAPS_RS06745	COG0805	protein transport
HAPS_RS06750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HAPS_RS06815	COG4974	Belongs to the 'phage' integrase family
HAPS_RS06825	COG0494	nUDIX hydrolase
HAPS_RS06855	COG1519	Transferase
HAPS_RS06870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HAPS_RS06875	COG0795	lipopolysaccharide-transporting ATPase activity
HAPS_RS06880	COG0795	lipopolysaccharide-transporting ATPase activity
HAPS_RS06890	COG0826	peptidase U32
HAPS_RS06895	COG3590	peptidase
HAPS_RS06930	COG0202	RNA polymerase activity
HAPS_RS06945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HAPS_RS06955	COG0201	protein transport
HAPS_RS06970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HAPS_RS06990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HAPS_RS07045	COG1876	peptidase activity
HAPS_RS07050	COG4172	Belongs to the ABC transporter superfamily
HAPS_RS07065	COG0747	negative chemotaxis
HAPS_RS07070	COG2005	Transcriptional regulator
HAPS_RS07075	COG0725	ABC transporter, periplasmic molybdate-binding protein
HAPS_RS07115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HAPS_RS07120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HAPS_RS07125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HAPS_RS07140	COG0019	diaminopimelate decarboxylase activity
HAPS_RS07145	COG0814	amino acid
HAPS_RS07160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAPS_RS07165	COG1966	Carbon starvation protein
HAPS_RS07180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAPS_RS07205	COG0024	Methionine aminopeptidase
HAPS_RS07210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HAPS_RS07215	COG1349	DNA-binding transcription factor activity
HAPS_RS07245	COG3111	PFAM Bacterial OB fold (BOF) protein
HAPS_RS07250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HAPS_RS07255	COG2850	peptidyl-arginine hydroxylation
HAPS_RS07260	COG4285	Biotin-protein ligase, N terminal
HAPS_RS07265	COG1268	BioY protein
HAPS_RS07270	COG0561	phosphatase activity
HAPS_RS07275	COG1040	competence protein
HAPS_RS07280	COG0084	hydrolase, TatD family'
HAPS_RS07285	COG0557	exoribonuclease II activity
HAPS_RS07290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HAPS_RS07295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HAPS_RS07300	COG0592	DNA-directed DNA polymerase activity
HAPS_RS07305	COG0762	integral membrane protein
HAPS_RS07315	COG4137	Cytochrome C assembly protein
HAPS_RS07320	COG4536	flavin adenine dinucleotide binding
HAPS_RS07330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HAPS_RS07335	COG0716	FMN binding
HAPS_RS07350	COG1045	serine acetyltransferase
HAPS_RS07360	COG0745	RESPONSE REGULATOR receiver
HAPS_RS07365	COG0295	cytidine deaminase activity
HAPS_RS07370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HAPS_RS07385	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HAPS_RS07390	COG0445	tRNA wobble uridine modification
HAPS_RS07395	COG1349	DNA-binding transcription factor activity
HAPS_RS07415	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HAPS_RS07420	COG1070	Carbohydrate kinase
HAPS_RS07430	COG0235	Class ii aldolase
HAPS_RS07445	COG3962	Belongs to the TPP enzyme family
HAPS_RS07455	COG0673	inositol 2-dehydrogenase activity
HAPS_RS07460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HAPS_RS07470	COG0673	inositol 2-dehydrogenase activity
HAPS_RS07475	COG1172	Belongs to the binding-protein-dependent transport system permease family
HAPS_RS07480	COG1129	ABC transporter
HAPS_RS07485	COG1879	ABC-type sugar transport system periplasmic component
HAPS_RS07495	COG3718	enzyme involved in inositol metabolism
HAPS_RS07500	COG2168	tRNA wobble position uridine thiolation
HAPS_RS07505	COG2923	Belongs to the DsrF TusC family
HAPS_RS07510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HAPS_RS07515	COG2964	Protein conserved in bacteria
HAPS_RS07520	COG0545	Peptidyl-prolyl cis-trans isomerase
HAPS_RS07525	COG2900	Belongs to the SlyX family
HAPS_RS07530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HAPS_RS07550	COG4545	Glutaredoxin-related protein
HAPS_RS07560	COG2852	Protein conserved in bacteria
HAPS_RS07575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HAPS_RS07585	COG2830	Protein of unknown function (DUF452)
HAPS_RS07590	COG2226	methyltransferase
HAPS_RS07595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HAPS_RS07610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HAPS_RS07615	COG4206	TonB-dependent receptor
HAPS_RS07615	COG1629	transport
HAPS_RS07625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HAPS_RS07630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAPS_RS07635	COG4558	Periplasmic binding protein
HAPS_RS07640	COG0758	DNA mediated transformation
HAPS_RS07680	COG3728	DNA packaging
HAPS_RS07695	COG0582	viral genome integration into host DNA
HAPS_RS07710	COG3276	selenocysteine insertion sequence binding
HAPS_RS07735	COG3171	Protein conserved in bacteria
HAPS_RS07740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HAPS_RS07745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HAPS_RS07760	COG0439	Biotin carboxylase
HAPS_RS07775	COG0051	transcription antitermination factor activity, RNA binding
HAPS_RS07790	COG0089	rRNA binding
HAPS_RS07800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HAPS_RS07810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HAPS_RS07845	COG0471	metal ion transport
HAPS_RS07845	COG0490	domain, Protein
HAPS_RS07865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HAPS_RS07890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HAPS_RS07895	COG1609	Transcriptional regulator
HAPS_RS07910	COG1172	Belongs to the binding-protein-dependent transport system permease family
HAPS_RS07915	COG1879	ABC-type sugar transport system periplasmic component
HAPS_RS07920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAPS_RS07925	COG0174	glutamine synthetase
HAPS_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
HAPS_RS07965	COG2801	Transposase and inactivated derivatives
HAPS_RS07970	COG2963	transposase activity
HAPS_RS07975	COG1074	ATP-dependent DNA helicase activity
HAPS_RS08010	COG1643	Atp-dependent helicase
HAPS_RS08015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HAPS_RS08020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HAPS_RS08025	COG0330	HflC and HflK could
HAPS_RS08040	COG2252	PERMEase
HAPS_RS08050	COG4221	oxidoreductase activity
HAPS_RS08055	COG0288	reversible hydration of carbon dioxide
HAPS_RS08065	COG1136	(ABC) transporter
HAPS_RS08070	COG4591	ABC-type transport system involved in lipoprotein release permease component
HAPS_RS08075	COG0402	S-adenosylhomocysteine deaminase activity
HAPS_RS08080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HAPS_RS08085	COG1252	NADH dehydrogenase
HAPS_RS08090	COG2226	methyltransferase
HAPS_RS08095	COG1560	Kdo2-lipid A biosynthetic process
HAPS_RS08105	COG1943	Transposase
HAPS_RS08125	COG4656	Part of a membrane complex involved in electron transport
HAPS_RS08130	COG2878	Part of a membrane complex involved in electron transport
HAPS_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAPS_RS08210	COG2017	converts alpha-aldose to the beta-anomer
HAPS_RS08220	COG2801	Transposase and inactivated derivatives
HAPS_RS08225	COG2927	DNA polymerase III (CHI subunit)
HAPS_RS08230	COG1022	Amp-dependent synthetase and ligase
HAPS_RS08270	COG3381	protein complex oligomerization
HAPS_RS08280	COG0791	NLP P60 protein
HAPS_RS08300	COG2259	Doxx family
HAPS_RS08350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HAPS_RS08360	COG1733	regulation of RNA biosynthetic process
HAPS_RS08380	COG1879	ABC-type sugar transport system periplasmic component
HAPS_RS08385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HAPS_RS08390	COG1129	ABC transporter
HAPS_RS08395	COG1482	cell wall glycoprotein biosynthetic process
HAPS_RS08405	COG3716	PTS system mannose fructose sorbose family IID component
HAPS_RS08410	COG3715	PTS system
HAPS_RS08415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HAPS_RS08415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAPS_RS08425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HAPS_RS08430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HAPS_RS08450	COG0606	chelatase, subunit chli
HAPS_RS08455	COG0470	DNA polymerase III
HAPS_RS08465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HAPS_RS08495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HAPS_RS08500	COG1238	metal cluster binding
HAPS_RS08510	COG1388	LysM domain
HAPS_RS08510	COG4942	peptidase
HAPS_RS08530	COG2995	paraquat-inducible protein a
HAPS_RS08540	COG0354	folic acid binding
HAPS_RS08595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HAPS_RS08600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HAPS_RS08605	COG4232	protein-disulfide reductase activity
HAPS_RS08610	COG0300	oxidoreductase activity
HAPS_RS08615	COG2826	transposase and inactivated derivatives, IS30 family
HAPS_RS08645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HAPS_RS08655	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HAPS_RS08675	COG3623	hexulose-6-phosphate isomerase
HAPS_RS08680	COG0235	Class ii aldolase
HAPS_RS08705	COG1694	Mazg nucleotide pyrophosphohydrolase
HAPS_RS08710	COG2610	gluconate transmembrane transporter activity
HAPS_RS08715	COG3265	gluconokinase activity
HAPS_RS08720	COG1609	Transcriptional regulator
HAPS_RS08725	COG3005	denitrification pathway
HAPS_RS08730	COG3043	anaerobic respiration
HAPS_RS08735	COG0348	domain, Protein
HAPS_RS08740	COG0437	4 iron, 4 sulfur cluster binding
HAPS_RS08750	COG3062	negative regulation of establishment of protein localization
HAPS_RS08755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HAPS_RS08760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HAPS_RS08770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HAPS_RS08775	COG3119	arylsulfatase activity
HAPS_RS08780	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HAPS_RS08785	COG0730	response to heat
HAPS_RS08790	COG0583	DNA-binding transcription factor activity
HAPS_RS08795	COG1309	transcriptional regulator
HAPS_RS08800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAPS_RS08805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HAPS_RS08810	COG3084	Protein conserved in bacteria
HAPS_RS08820	COG1414	Transcriptional regulator
HAPS_RS08830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HAPS_RS08850	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HAPS_RS08870	COG3550	peptidyl-serine autophosphorylation
HAPS_RS08920	COG0789	Transcriptional regulator
HAPS_RS08945	COG4804	nuclease activity
HAPS_RS08950	COG0352	thiamine-phosphate diphosphorylase activity
HAPS_RS08955	COG0351	phosphomethylpyrimidine kinase
HAPS_RS08985	COG3550	peptidyl-serine autophosphorylation
HAPS_RS09020	COG0742	ribosomal rna small subunit methyltransferase
HAPS_RS09025	COG0552	protein localization to endoplasmic reticulum
HAPS_RS09030	COG2884	Cell division ATP-binding protein ftsE
HAPS_RS09050	COG0625	glutathione transferase activity
HAPS_RS09060	COG1349	DNA-binding transcription factor activity
HAPS_RS09065	COG2084	Dehydrogenase
HAPS_RS09070	COG3395	kinase activity
HAPS_RS09075	COG0235	Class ii aldolase
HAPS_RS09080	COG3622	Belongs to the hyi family
HAPS_RS09085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAPS_RS09090	COG2610	gluconate transmembrane transporter activity
HAPS_RS09110	COG0277	FAD linked oxidase domain protein
HAPS_RS09145	COG3161	chorismate lyase activity
HAPS_RS09155	COG0180	Tryptophanyl-tRNA synthetase
HAPS_RS09180	COG0387	Pfam Sodium calcium exchanger
HAPS_RS09205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HAPS_RS09210	COG0594	ribonuclease P activity
HAPS_RS09215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HAPS_RS09220	COG1739	Uncharacterized protein family UPF0029
HAPS_RS09225	COG2358	TRAP transporter, solute receptor (TAXI family
HAPS_RS09245	COG4804	nuclease activity
HAPS_RS09265	COG0758	DNA mediated transformation
HAPS_RS09285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HAPS_RS09290	COG0569	domain protein
HAPS_RS09295	COG0686	Belongs to the AlaDH PNT family
HAPS_RS09300	COG0733	neurotransmitter:sodium symporter activity
HAPS_RS09345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAPS_RS09355	COG0561	phosphatase activity
HAPS_RS09365	COG2195	Cleaves the N-terminal amino acid of tripeptides
HAPS_RS09380	COG3328	transposase activity
HAPS_RS09385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HAPS_RS09400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HAPS_RS09405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HAPS_RS09415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HAPS_RS09420	COG0335	large ribosomal subunit rRNA binding
HAPS_RS09435	COG0335	large ribosomal subunit rRNA binding
HAPS_RS09455	COG1757	Na H antiporter
HAPS_RS09470	COG3328	transposase activity
HAPS_RS09525	COG1522	sequence-specific DNA binding
HAPS_RS09530	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HAPS_RS09535	COG3085	chromosome segregation
HAPS_RS09570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAPS_RS09580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAPS_RS09585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HAPS_RS09590	COG2129	metallophosphoesterase
HAPS_RS09595	COG3172	ATPase kinase involved in NAD metabolism
HAPS_RS09600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HAPS_RS09610	COG3700	Belongs to the class B bacterial acid phosphatase family
HAPS_RS09630	COG2990	Protein conserved in bacteria
HAPS_RS09635	COG0525	valine-tRNA ligase activity
HAPS_RS09640	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HAPS_RS09650	COG3177	Filamentation induced by cAMP protein fic
HAPS_RS09675	COG0159	tryptophan synthase activity
HAPS_RS09685	COG0134	indole-3-glycerol-phosphate synthase activity
HAPS_RS09685	COG0135	phosphoribosylanthranilate isomerase activity
HAPS_RS09695	COG0512	Glutamine amidotransferase of anthranilate synthase
HAPS_RS09700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAPS_RS09710	COG2801	Transposase and inactivated derivatives
HAPS_RS09715	COG1187	pseudouridine synthase activity
HAPS_RS09720	COG0009	L-threonylcarbamoyladenylate synthase
HAPS_RS09730	COG2166	iron-sulfur cluster assembly
HAPS_RS09740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HAPS_RS09755	COG1459	type II secretion system
HAPS_RS09760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HAPS_RS09765	COG2852	Protein conserved in bacteria
HAPS_RS09775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HAPS_RS09780	COG0194	GDP metabolic process
HAPS_RS09790	COG0210	DNA helicase
HAPS_RS09835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HAPS_RS09860	COG0456	acetyltransferase
HAPS_RS09875	COG0513	Belongs to the DEAD box helicase family
HAPS_RS09885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HAPS_RS09890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HAPS_RS09935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HAPS_RS09940	COG2003	Belongs to the UPF0758 family
HAPS_RS09965	COG0745	RESPONSE REGULATOR receiver
HAPS_RS09970	COG0642	Histidine kinase
HAPS_RS09985	COG1085	galactose-1-phosphate uridylyltransferase
HAPS_RS10030	COG0697	spore germination
HAPS_RS10035	COG0697	spore germination
HAPS_RS10050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HAPS_RS10065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HAPS_RS10070	COG4145	pantothenate transmembrane transporter activity
HAPS_RS10075	COG3924	membrane
HAPS_RS10085	COG0598	Magnesium transport protein CorA
HAPS_RS10090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HAPS_RS10100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HAPS_RS10110	COG0545	Peptidyl-prolyl cis-trans isomerase
HAPS_RS10120	COG0204	Acyl-transferase
HAPS_RS10145	COG2190	(PTS) system
HAPS_RS10145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HAPS_RS10145	COG1263	PTS System
HAPS_RS10160	COG0582	viral genome integration into host DNA
HAPS_RS10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAPS_RS10180	COG0765	amino acid transport
HAPS_RS10185	COG1126	abc transporter atp-binding protein
HAPS_RS10200	COG0493	'glutamate synthase
HAPS_RS10245	COG0251	oxidation-reduction process
HAPS_RS10250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HAPS_RS10255	COG0583	DNA-binding transcription factor activity
HAPS_RS10260	COG1011	Hydrolase
HAPS_RS10265	COG0583	DNA-binding transcription factor activity
HAPS_RS10275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HAPS_RS10280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAPS_RS10295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HAPS_RS10300	COG1426	Protein conserved in bacteria
HAPS_RS10305	COG0616	signal peptide processing
HAPS_RS10315	COG3201	nicotinamide mononucleotide transporter
HAPS_RS10320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HAPS_RS10325	COG4133	protoheme IX ABC transporter activity
HAPS_RS10330	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HAPS_RS10335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HAPS_RS10340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HAPS_RS10345	COG0471	metal ion transport
HAPS_RS10350	COG0126	phosphoglycerate kinase activity
HAPS_RS10355	COG0191	fructose-bisphosphate aldolase activity
HAPS_RS10360	COG4172	Belongs to the ABC transporter superfamily
HAPS_RS10365	COG0778	Nitroreductase
HAPS_RS10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HAPS_RS10400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HAPS_RS10400	COG0517	IMP dehydrogenase activity
HAPS_RS10405	COG3063	Type IV pilus biogenesis stability protein PilW
HAPS_RS10420	COG2944	sequence-specific DNA binding
HAPS_RS10470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HAPS_RS10495	COG0330	HflC and HflK could
HAPS_RS10500	COG0330	HflC and HflK could
HAPS_RS10505	COG0456	acetyltransferase
HAPS_RS10510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HAPS_RS10525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAPS_RS10530	COG1538	Outer membrane efflux protein
HAPS_RS10535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HAPS_RS10540	COG0346	lactoylglutathione lyase activity
HAPS_RS10550	COG2911	Protein conserved in bacteria
HAPS_RS10570	COG0280	phosphate acetyltransferase
HAPS_RS10570	COG0281	malic enzyme
HAPS_RS10575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HAPS_RS10580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HAPS_RS10600	COG0469	pyruvate kinase activity
HAPS_RS10605	COG2062	phosphohistidine phosphatase, SixA
HAPS_RS10635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HAPS_RS10645	COG0583	DNA-binding transcription factor activity
HAPS_RS10660	COG0500	methyltransferase
HAPS_RS10665	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HAPS_RS10680	COG0308	aminopeptidase N
HAPS_RS10690	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HAPS_RS10695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HAPS_RS10700	COG0802	atpase or kinase
HAPS_RS10705	COG0860	N-Acetylmuramoyl-L-alanine amidase
HAPS_RS10705	COG1388	LysM domain
HAPS_RS10715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HAPS_RS10720	COG1083	cytidylyl-transferase
HAPS_RS10730	COG1216	Glycosyl transferase, family 2
HAPS_RS10735	COG1216	Glycosyl transferase, family 2
HAPS_RS10740	COG1138	Cytochrome C-type biogenesis protein
HAPS_RS10750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HAPS_RS10755	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HAPS_RS10760	COG1077	Cell shape determining protein MreB Mrl
HAPS_RS10765	COG1792	Involved in formation and maintenance of cell shape
HAPS_RS10770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HAPS_RS10775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HAPS_RS10780	COG4783	chaperone-mediated protein folding
HAPS_RS10805	COG4771	TonB-dependent receptor
HAPS_RS10805	COG1629	transport
HAPS_RS10810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HAPS_RS10820	COG1560	Kdo2-lipid A biosynthetic process
HAPS_RS10825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HAPS_RS10830	COG0393	Putative heavy-metal-binding
HAPS_RS10835	COG2983	Belongs to the UPF0260 family
HAPS_RS10840	COG0556	nucleotide-excision repair
HAPS_RS10850	COG4171	peptide transport system, permease
HAPS_RS10855	COG4172	Belongs to the ABC transporter superfamily
HAPS_RS10870	COG0187	DNA topoisomerase II activity
HAPS_RS10875	COG0753	catalase activity
HAPS_RS10880	COG1408	metallophosphoesterase
HAPS_RS10885	COG3120	sequence-specific DNA binding
HAPS_RS10890	COG1067	ATP-dependent peptidase activity
HAPS_RS10925	COG0534	Mate efflux family protein
HAPS_RS10930	COG0564	pseudouridine synthase activity
HAPS_RS10935	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HAPS_RS10945	COG3639	organic phosphonate transmembrane transporter activity
HAPS_RS10950	COG3639	organic phosphonate transmembrane transporter activity
HAPS_RS10965	COG0730	response to heat
HAPS_RS10980	COG0716	FMN binding
HAPS_RS10985	COG0735	belongs to the Fur family
HAPS_RS10990	COG3008	intermembrane lipid transfer
HAPS_RS10995	COG3676	manually curated
HAPS_RS11000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HAPS_RS11005	COG0793	Belongs to the peptidase S41A family
HAPS_RS11010	COG2989	Protein conserved in bacteria
HAPS_RS11015	COG3108	Peptidase M15
HAPS_RS11020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAPS_RS11025	COG2853	Lipoprotein
HAPS_RS11030	COG2932	Transcriptional regulator
HAPS_RS11035	COG0626	cystathionine gamma-synthase activity
HAPS_RS11045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HAPS_RS11050	COG0538	isocitrate dehydrogenase activity
HAPS_RS11060	COG0372	Belongs to the citrate synthase family
HAPS_RS11065	COG0563	adenylate kinase activity
HAPS_RS11070	COG0733	neurotransmitter:sodium symporter activity
HAPS_RS11075	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HAPS_RS11080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HAPS_RS11085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HAPS_RS11090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HAPS_RS11115	COG4796	Type ii and iii secretion system protein
HAPS_RS11125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HAPS_RS11130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HAPS_RS11135	COG1280	lysine exporter protein (LysE YggA)
HAPS_RS11140	COG3118	belongs to the thioredoxin family
HAPS_RS11150	COG2050	protein possibly involved in aromatic compounds catabolism
HAPS_RS11155	COG0247	lactate metabolic process
HAPS_RS11155	COG0277	FAD linked oxidase domain protein
HAPS_RS11160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HAPS_RS11160	COG2885	chlorophyll binding
HAPS_RS11185	COG0732	type I restriction modification DNA specificity domain
HAPS_RS11195	COG5295	Hep Hag repeat protein
HAPS_RS11340	COG4974	Belongs to the 'phage' integrase family
HAPS_RS11390	COG4178	(ABC) transporter
HAPS_RS11425	COG3422	double-strand break repair
HAPS_RS11450	COG3422	double-strand break repair
HAPS_RS11510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HAPS_RS11540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HAPS_RS11550	COG3328	transposase activity
HAPS_RS11570	COG2271	Major facilitator Superfamily
HAPS_RS11630	COG3328	transposase activity
HAPS_RS11635	COG0754	glutathionylspermidine amidase activity
HAPS_RS11655	COG2963	transposase activity
HAPS_RS11715	COG0583	DNA-binding transcription factor activity
HAPS_RS11725	COG2963	transposase activity
HAPS_RS11755	COG3328	transposase activity