locus-tag	class	description
GOX_RS00140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GOX_RS00360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GOX_RS00545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GOX_RS00890	COG0277	FAD linked oxidase domain protein
GOX_RS00890	COG0247	lactate metabolic process
GOX_RS00955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GOX_RS01005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GOX_RS01015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GOX_RS01055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GOX_RS01145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GOX_RS01155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GOX_RS01170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GOX_RS01175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GOX_RS01195	COG3104	oligopeptide transport
GOX_RS01205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GOX_RS01205	COG0321	lipoyl(octanoyl) transferase activity
GOX_RS01210	COG0084	hydrolase, TatD family'
GOX_RS01215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOX_RS01225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GOX_RS01230	COG1686	Belongs to the peptidase S11 family
GOX_RS01235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GOX_RS01240	COG2951	lytic endotransglycosylase activity
GOX_RS01260	COG1968	undecaprenyl-diphosphatase activity
GOX_RS01265	COG0531	amino acid
GOX_RS01290	COG2890	protein-(glutamine-N5) methyltransferase activity
GOX_RS01300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GOX_RS01305	COG0124	histidyl-tRNA synthetase
GOX_RS01310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GOX_RS01320	COG2070	2-Nitropropane dioxygenase
GOX_RS01330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GOX_RS01345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GOX_RS01350	COG1040	competence protein
GOX_RS01370	COG0321	lipoyl(octanoyl) transferase activity
GOX_RS01385	COG0484	heat shock protein binding
GOX_RS01400	COG0076	glutamate decarboxylase activity
GOX_RS01415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GOX_RS01420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GOX_RS01425	COG5001	Diguanylate cyclase
GOX_RS01425	COG3300	MHYT domain
GOX_RS01440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GOX_RS01445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GOX_RS01455	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GOX_RS01465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GOX_RS01470	COG0606	chelatase, subunit chli
GOX_RS01475	COG0626	cystathionine gamma-synthase activity
GOX_RS01480	COG2897	thiosulfate sulfurtransferase activity
GOX_RS01485	COG0628	permease
GOX_RS01495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GOX_RS01500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GOX_RS01505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GOX_RS01515	COG1381	Involved in DNA repair and RecF pathway recombination
GOX_RS01520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GOX_RS01525	COG0052	Belongs to the universal ribosomal protein uS2 family
GOX_RS01535	COG1136	(ABC) transporter
GOX_RS01540	COG4591	ABC-type transport system involved in lipoprotein release permease component
GOX_RS01545	COG0442	prolyl-tRNA aminoacylation
GOX_RS01555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GOX_RS01570	COG0776	regulation of translation
GOX_RS01580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GOX_RS01585	COG0740	serine-type endopeptidase activity
GOX_RS01590	COG0544	peptidyl-prolyl cis-trans isomerase activity
GOX_RS01600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GOX_RS01600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GOX_RS01610	COG0513	Belongs to the DEAD box helicase family
GOX_RS01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GOX_RS01620	COG0316	Belongs to the HesB IscA family
GOX_RS01625	COG2151	metal-sulfur cluster biosynthetic enzyme
GOX_RS01630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GOX_RS01635	COG0719	Fe-S assembly protein
GOX_RS01640	COG0396	ATPase activity
GOX_RS01645	COG0719	Fe-S assembly protein
GOX_RS01650	COG1959	2 iron, 2 sulfur cluster binding
GOX_RS01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GOX_RS01680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GOX_RS01700	COG0628	permease
GOX_RS01715	COG0776	regulation of translation
GOX_RS01720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GOX_RS01725	COG0416	fatty acid biosynthetic process
GOX_RS01730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GOX_RS01750	COG0745	RESPONSE REGULATOR receiver
GOX_RS01760	COG0242	peptide deformylase activity
GOX_RS01765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GOX_RS01770	COG1505	serine-type exopeptidase activity
GOX_RS01775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GOX_RS01795	COG1522	sequence-specific DNA binding
GOX_RS01800	COG0492	ferredoxin-NADP+ reductase activity
GOX_RS01815	COG0776	regulation of translation
GOX_RS01820	COG0616	signal peptide processing
GOX_RS01825	COG4957	zinc ion binding
GOX_RS01830	COG1573	uracil-dna glycosylase
GOX_RS01835	COG1289	transmembrane transporter activity
GOX_RS01845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GOX_RS01850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GOX_RS01855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GOX_RS01860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GOX_RS01870	COG3750	Belongs to the UPF0335 family
GOX_RS01875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GOX_RS01885	COG0657	acetylesterase activity
GOX_RS01890	COG2001	Belongs to the MraZ family
GOX_RS01895	COG0275	rRNA processing
GOX_RS01910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GOX_RS01920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GOX_RS01925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GOX_RS01935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GOX_RS01940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GOX_RS01945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GOX_RS01950	COG1181	Belongs to the D-alanine--D-alanine ligase family
GOX_RS01955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GOX_RS01960	COG0849	cell division
GOX_RS01975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GOX_RS01980	COG0497	DNA recombination
GOX_RS01985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GOX_RS01990	COG1253	flavin adenine dinucleotide binding
GOX_RS01995	COG1335	isochorismatase
GOX_RS02015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GOX_RS02030	COG0328	RNA-DNA hybrid ribonuclease activity
GOX_RS02035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GOX_RS02040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GOX_RS02050	COG1297	OPT oligopeptide transporter protein
GOX_RS02060	COG2096	Adenosyltransferase
GOX_RS02100	COG0473	3-isopropylmalate dehydrogenase activity
GOX_RS02105	COG0066	3-isopropylmalate dehydratase activity
GOX_RS02110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GOX_RS02115	COG0335	large ribosomal subunit rRNA binding
GOX_RS02120	COG0336	Belongs to the RNA methyltransferase TrmD family
GOX_RS02125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GOX_RS02130	COG0228	four-way junction DNA binding
GOX_RS02150	COG0513	Belongs to the DEAD box helicase family
GOX_RS02155	COG0778	Nitroreductase
GOX_RS02160	COG2813	Specifically methylates the guanine in position
GOX_RS02160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOX_RS02165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GOX_RS02180	COG0583	DNA-binding transcription factor activity
GOX_RS02195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GOX_RS02200	COG1984	allophanate hydrolase subunit 2
GOX_RS02205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GOX_RS02275	COG1692	metallophosphoesterase
GOX_RS02280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GOX_RS02330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GOX_RS02335	COG0483	inositol monophosphate 1-phosphatase activity
GOX_RS02355	COG0481	GTPase activity
GOX_RS02375	COG2252	PERMEase
GOX_RS02400	COG1722	exodeoxyribonuclease VII activity
GOX_RS02410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GOX_RS02415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GOX_RS02420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GOX_RS02425	COG0137	argininosuccinate synthase activity
GOX_RS02430	COG0545	Peptidyl-prolyl cis-trans isomerase
GOX_RS02450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GOX_RS02455	COG0072	phenylalanine-tRNA ligase activity
GOX_RS02455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOX_RS02460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GOX_RS02465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GOX_RS02470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GOX_RS02475	COG4993	Dehydrogenase
GOX_RS02490	COG2166	iron-sulfur cluster assembly
GOX_RS02515	COG2884	Cell division ATP-binding protein ftsE
GOX_RS02540	COG1271	oxidase subunit
GOX_RS02545	COG1294	oxidase, subunit
GOX_RS02550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOX_RS02560	COG0688	phosphatidylethanolamine metabolic process
GOX_RS02565	COG1183	phosphatidylcholine synthase activity
GOX_RS02570	COG1940	carbohydrate kinase activity
GOX_RS02575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GOX_RS02580	COG0649	NAD binding
GOX_RS02605	COG0656	L-ascorbic acid biosynthetic process
GOX_RS02620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GOX_RS02630	COG1218	3'(2'),5'-bisphosphate nucleotidase
GOX_RS02635	COG0009	L-threonylcarbamoyladenylate synthase
GOX_RS02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GOX_RS02670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GOX_RS02675	COG0359	binds to the 23S rRNA
GOX_RS02680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GOX_RS02685	COG0360	Binds together with S18 to 16S ribosomal RNA
GOX_RS02695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GOX_RS02700	COG0358	DNA primase activity
GOX_RS02710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GOX_RS02750	COG2084	Dehydrogenase
GOX_RS02765	COG0505	Belongs to the CarA family
GOX_RS02770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GOX_RS02780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GOX_RS02785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GOX_RS02795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GOX_RS02800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOX_RS02810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GOX_RS02820	COG0793	Belongs to the peptidase S41A family
GOX_RS02830	COG0494	nUDIX hydrolase
GOX_RS02835	COG1132	(ABC) transporter
GOX_RS02840	COG0617	tRNA 3'-terminal CCA addition
GOX_RS02850	COG0714	Associated with various cellular activities
GOX_RS02875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GOX_RS02880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GOX_RS02900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GOX_RS02925	COG2814	Major facilitator Superfamily
GOX_RS02930	COG0203	ribosomal protein L17
GOX_RS02935	COG0202	RNA polymerase activity
GOX_RS02940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GOX_RS02945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GOX_RS02950	COG0563	adenylate kinase activity
GOX_RS02960	COG0200	Binds to the 23S rRNA
GOX_RS02965	COG1841	ribosomal large subunit assembly
GOX_RS02970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GOX_RS02975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GOX_RS02980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GOX_RS02985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GOX_RS02990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GOX_RS02995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GOX_RS03000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GOX_RS03005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GOX_RS03010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GOX_RS03015	COG0255	Belongs to the universal ribosomal protein uL29 family
GOX_RS03020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GOX_RS03025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GOX_RS03030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GOX_RS03035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GOX_RS03040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GOX_RS03045	COG0089	rRNA binding
GOX_RS03050	COG0088	Forms part of the polypeptide exit tunnel
GOX_RS03055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GOX_RS03060	COG0051	transcription antitermination factor activity, RNA binding
GOX_RS03065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GOX_RS03070	COG0049	tRNA binding
GOX_RS03075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GOX_RS03080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GOX_RS03085	COG0085	RNA polymerase activity
GOX_RS03090	COG0222	ribosome binding
GOX_RS03095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GOX_RS03100	COG0081	regulation of translation
GOX_RS03105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GOX_RS03125	COG5002	protein histidine kinase activity
GOX_RS03130	COG0745	RESPONSE REGULATOR receiver
GOX_RS03145	COG2081	HI0933 family
GOX_RS03155	COG0850	regulation of cytokinetic process
GOX_RS03165	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GOX_RS03200	COG0495	leucyl-tRNA aminoacylation
GOX_RS03215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GOX_RS03225	COG0679	Auxin Efflux Carrier
GOX_RS03230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GOX_RS03235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GOX_RS03250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GOX_RS03260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GOX_RS03285	COG0138	bifunctional purine biosynthesis protein purh
GOX_RS03290	COG1988	membrane-bound metal-dependent
GOX_RS03295	COG0800	Aldolase
GOX_RS03300	COG0129	dihydroxy-acid dehydratase activity
GOX_RS03315	COG0439	Biotin carboxylase
GOX_RS03320	COG0511	ligase activity, forming carbon-carbon bonds
GOX_RS03325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GOX_RS03335	COG1295	ribonuclease BN
GOX_RS03345	COG3585	molybdate ion transport
GOX_RS03360	COG0314	molybdopterin synthase activity
GOX_RS03365	COG0746	molybdenum cofactor guanylyltransferase activity
GOX_RS03365	COG0315	cyclic pyranopterin monophosphate synthase activity
GOX_RS03370	COG0315	cyclic pyranopterin monophosphate synthase activity
GOX_RS03375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GOX_RS03380	COG0303	'Molybdopterin
GOX_RS03395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GOX_RS03400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GOX_RS03405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GOX_RS03425	COG0697	spore germination
GOX_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS03440	COG0659	secondary active sulfate transmembrane transporter activity
GOX_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GOX_RS03465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GOX_RS03470	COG1923	regulation of RNA biosynthetic process
GOX_RS03475	COG2204	response regulator
GOX_RS03495	COG0596	Alpha beta hydrolase
GOX_RS03500	COG1082	Xylose isomerase domain protein TIM barrel
GOX_RS03510	COG0167	dihydroorotate dehydrogenase activity
GOX_RS03515	COG3264	Mechanosensitive ion channel
GOX_RS03515	COG1196	nuclear chromosome segregation
GOX_RS03540	COG0131	Imidazoleglycerol-phosphate dehydratase
GOX_RS03550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GOX_RS03555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GOX_RS03560	COG0107	imidazoleglycerol-phosphate synthase activity
GOX_RS03565	COG0140	phosphoribosyl-ATP diphosphatase activity
GOX_RS03625	COG1942	4-Oxalocrotonate Tautomerase
GOX_RS03630	COG1733	regulation of RNA biosynthetic process
GOX_RS03635	COG1012	belongs to the aldehyde dehydrogenase family
GOX_RS03645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GOX_RS03650	COG1902	pentaerythritol trinitrate reductase activity
GOX_RS03655	COG0640	Transcriptional regulator
GOX_RS03670	COG0564	pseudouridine synthase activity
GOX_RS03680	COG0126	phosphoglycerate kinase activity
GOX_RS03710	COG1522	sequence-specific DNA binding
GOX_RS03725	COG4993	Dehydrogenase
GOX_RS03735	COG1393	Belongs to the ArsC family
GOX_RS03750	COG0405	Gamma-glutamyltransferase
GOX_RS03755	COG0583	DNA-binding transcription factor activity
GOX_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS03775	COG0659	secondary active sulfate transmembrane transporter activity
GOX_RS03780	COG2824	Alkylphosphonate utilization operon protein PhnA
GOX_RS03785	COG2837	iron assimilation
GOX_RS03800	COG0848	biopolymer transport protein
GOX_RS03825	COG4774	siderophore transport
GOX_RS03850	COG0477	Major facilitator Superfamily
GOX_RS03855	COG0006	proline dipeptidase activity
GOX_RS03880	COG0754	glutathionylspermidine amidase activity
GOX_RS03885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GOX_RS03915	COG3128	pkhd-type hydroxylase
GOX_RS03920	COG5001	Diguanylate cyclase
GOX_RS03965	COG3620	sequence-specific DNA binding
GOX_RS03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOX_RS03980	COG3453	Protein conserved in bacteria
GOX_RS03990	COG0450	alkyl hydroperoxide reductase
GOX_RS04005	COG1609	Transcriptional regulator
GOX_RS04025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GOX_RS04030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GOX_RS04035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GOX_RS04040	COG2010	Cytochrome c
GOX_RS04040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GOX_RS04060	COG0438	transferase activity, transferring glycosyl groups
GOX_RS04070	COG0612	Peptidase, M16
GOX_RS04080	COG1215	transferase activity, transferring glycosyl groups
GOX_RS04090	COG0539	negative regulation of cytoplasmic translation
GOX_RS04095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GOX_RS04100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GOX_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS04120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GOX_RS04125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GOX_RS04140	COG0024	Methionine aminopeptidase
GOX_RS04145	COG1686	Belongs to the peptidase S11 family
GOX_RS04150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GOX_RS04170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GOX_RS04175	COG3394	polysaccharide catabolic process
GOX_RS04180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GOX_RS04195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GOX_RS04200	COG1253	flavin adenine dinucleotide binding
GOX_RS04215	COG1706	bacterial-type flagellum-dependent cell motility
GOX_RS04235	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GOX_RS04245	COG1074	ATP-dependent DNA helicase activity
GOX_RS04255	COG0802	atpase or kinase
GOX_RS04260	COG0438	transferase activity, transferring glycosyl groups
GOX_RS04265	COG0492	ferredoxin-NADP+ reductase activity
GOX_RS04270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GOX_RS04285	COG1217	gtp-binding protein TYPA
GOX_RS04290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GOX_RS04295	COG2746	aminoglycoside 3-N-acetyltransferase activity
GOX_RS04315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GOX_RS04330	COG0784	Response regulator, receiver
GOX_RS04330	COG4191	Histidine kinase
GOX_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS04340	COG1289	transmembrane transporter activity
GOX_RS04345	COG0583	DNA-binding transcription factor activity
GOX_RS04350	COG2814	Major facilitator Superfamily
GOX_RS04370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GOX_RS04380	COG4608	Belongs to the ABC transporter superfamily
GOX_RS04385	COG0444	Belongs to the ABC transporter superfamily
GOX_RS04390	COG0601	transmembrane transport
GOX_RS04395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOX_RS04405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GOX_RS04415	COG2217	Heavy metal translocating P-type atpase
GOX_RS04420	COG4178	(ABC) transporter
GOX_RS04440	COG2608	mercury ion transmembrane transporter activity
GOX_RS04450	COG2132	Multicopper oxidase
GOX_RS04465	COG1937	Protein conserved in bacteria
GOX_RS04485	COG3540	Alkaline phosphatase
GOX_RS04505	COG1032	radical SAM domain protein
GOX_RS04510	COG0500	methyltransferase
GOX_RS04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GOX_RS04525	COG3706	GGDEF domain
GOX_RS04530	COG1289	transmembrane transporter activity
GOX_RS04615	COG1505	serine-type exopeptidase activity
GOX_RS04625	COG0745	RESPONSE REGULATOR receiver
GOX_RS04635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GOX_RS04640	COG0581	inorganic phosphate transmembrane transporter activity
GOX_RS04650	COG0783	Belongs to the Dps family
GOX_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS04700	COG0583	DNA-binding transcription factor activity
GOX_RS04720	COG0156	8-amino-7-oxononanoate synthase activity
GOX_RS04730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GOX_RS04730	COG4106	trans-aconitate 2-methyltransferase activity
GOX_RS04735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GOX_RS04735	COG4106	trans-aconitate 2-methyltransferase activity
GOX_RS04740	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GOX_RS04745	COG2943	transferase activity, transferring hexosyl groups
GOX_RS04760	COG1566	PFAM secretion protein HlyD family protein
GOX_RS04780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GOX_RS04800	COG4974	Belongs to the 'phage' integrase family
GOX_RS04835	COG0004	ammonium transporteR
GOX_RS04840	COG0347	Belongs to the P(II) protein family
GOX_RS04850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GOX_RS04885	COG0488	(ABC) transporter
GOX_RS04895	COG1289	transmembrane transporter activity
GOX_RS04905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GOX_RS04935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GOX_RS04940	COG2835	tetraacyldisaccharide 4'-kinase activity
GOX_RS04960	COG1396	sequence-specific DNA binding
GOX_RS04965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GOX_RS04980	COG4957	zinc ion binding
GOX_RS05000	COG0778	Nitroreductase
GOX_RS05020	COG0191	fructose-bisphosphate aldolase activity
GOX_RS05035	COG2814	Major facilitator Superfamily
GOX_RS05040	COG1566	PFAM secretion protein HlyD family protein
GOX_RS05045	COG1573	uracil-dna glycosylase
GOX_RS05055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GOX_RS05075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GOX_RS05085	COG1760	l-serine dehydratase
GOX_RS05110	COG0590	tRNA wobble adenosine to inosine editing
GOX_RS05115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GOX_RS05115	COG0666	response to abiotic stimulus
GOX_RS05120	COG1187	pseudouridine synthase activity
GOX_RS05125	COG0742	ribosomal rna small subunit methyltransferase
GOX_RS05135	COG0564	pseudouridine synthase activity
GOX_RS05155	COG2814	Major facilitator Superfamily
GOX_RS05170	COG0735	belongs to the Fur family
GOX_RS05175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GOX_RS05190	COG1660	Displays ATPase and GTPase activities
GOX_RS05195	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GOX_RS05210	COG2205	protein histidine kinase activity
GOX_RS05215	COG0745	RESPONSE REGULATOR receiver
GOX_RS05220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GOX_RS05225	COG0859	PFAM glycosyl transferase family 9
GOX_RS05235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GOX_RS05240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GOX_RS05265	COG2205	protein histidine kinase activity
GOX_RS05270	COG0745	RESPONSE REGULATOR receiver
GOX_RS05285	COG1643	Atp-dependent helicase
GOX_RS05290	COG1278	Cold shock
GOX_RS05295	COG0778	Nitroreductase
GOX_RS05300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOX_RS05305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GOX_RS05310	COG2814	Major facilitator Superfamily
GOX_RS05320	COG1695	Transcriptional regulator
GOX_RS05345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GOX_RS05365	COG1956	GAF domain-containing protein
GOX_RS05370	COG0246	Mannitol dehydrogenase
GOX_RS05375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GOX_RS05380	COG0717	Belongs to the dCTP deaminase family
GOX_RS05395	COG0438	transferase activity, transferring glycosyl groups
GOX_RS05400	COG4993	Dehydrogenase
GOX_RS05405	COG4993	Dehydrogenase
GOX_RS05415	COG0443	Heat shock 70 kDa protein
GOX_RS05420	COG0484	heat shock protein binding
GOX_RS05425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GOX_RS05430	COG1959	2 iron, 2 sulfur cluster binding
GOX_RS05435	COG1017	nitric oxide dioxygenase activity
GOX_RS05435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GOX_RS05440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GOX_RS05445	COG1733	regulation of RNA biosynthetic process
GOX_RS05450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GOX_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS05460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GOX_RS05465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GOX_RS05470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GOX_RS05470	COG0644	oxidoreductase
GOX_RS05485	COG0681	Belongs to the peptidase S26 family
GOX_RS05495	COG1621	beta-fructofuranosidase activity
GOX_RS05500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GOX_RS05510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GOX_RS05515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GOX_RS05520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GOX_RS05535	COG0657	acetylesterase activity
GOX_RS05550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GOX_RS05565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GOX_RS05570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GOX_RS05580	COG0629	single-stranded DNA binding
GOX_RS05585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GOX_RS05605	COG1054	Belongs to the UPF0176 family
GOX_RS05625	COG0402	S-adenosylhomocysteine deaminase activity
GOX_RS05645	COG2351	hydroxyisourate hydrolase activity
GOX_RS05660	COG2072	flavoprotein involved in K transport
GOX_RS05695	COG1733	regulation of RNA biosynthetic process
GOX_RS05730	COG2814	Major facilitator Superfamily
GOX_RS05735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GOX_RS05755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GOX_RS05760	COG2814	Major facilitator Superfamily
GOX_RS05770	COG0175	sulfate reduction
GOX_RS05775	COG0175	sulfate reduction
GOX_RS05785	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GOX_RS05790	COG1842	Phage shock protein A
GOX_RS05810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GOX_RS05815	COG1127	ABC transporter
GOX_RS05875	COG1957	nucleoside hydrolase
GOX_RS05890	COG0300	oxidoreductase activity
GOX_RS05895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GOX_RS05905	COG4786	Flagellar basal body rod
GOX_RS05940	COG5001	Diguanylate cyclase
GOX_RS05940	COG3300	MHYT domain
GOX_RS05945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GOX_RS05960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GOX_RS06000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GOX_RS06005	COG3047	cAMP biosynthetic process
GOX_RS06010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GOX_RS06020	COG0415	Belongs to the DNA photolyase family
GOX_RS06035	COG0307	riboflavin synthase, alpha
GOX_RS06040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GOX_RS06040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GOX_RS06045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GOX_RS06055	COG0535	radical SAM domain protein
GOX_RS06065	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GOX_RS06070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GOX_RS06085	COG0194	GDP metabolic process
GOX_RS06090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GOX_RS06095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GOX_RS06145	COG0513	Belongs to the DEAD box helicase family
GOX_RS06150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GOX_RS06155	COG0424	maF-like protein
GOX_RS06160	COG1530	ribonuclease E activity
GOX_RS06195	COG1621	beta-fructofuranosidase activity
GOX_RS06205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GOX_RS06210	COG4139	cobalamin transport
GOX_RS06220	COG4206	TonB-dependent receptor
GOX_RS06240	COG0420	3'-5' exonuclease activity
GOX_RS06245	COG4717	serine-type aminopeptidase activity
GOX_RS06260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GOX_RS06260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GOX_RS06265	COG0326	Molecular chaperone. Has ATPase activity
GOX_RS06280	COG1749	Flagellar hook protein flgE
GOX_RS06285	COG0534	Mate efflux family protein
GOX_RS06320	COG1981	membrane
GOX_RS06325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GOX_RS06330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GOX_RS06335	COG0424	maF-like protein
GOX_RS06345	COG2942	2-epimerase
GOX_RS06370	COG1116	anion transmembrane transporter activity
GOX_RS06380	COG2814	Major facilitator Superfamily
GOX_RS06395	COG1091	dTDP-4-dehydrorhamnose reductase activity
GOX_RS06400	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GOX_RS06450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GOX_RS06470	COG0357	Ribosomal RNA small subunit methyltransferase G
GOX_RS06475	COG0445	tRNA wobble uridine modification
GOX_RS06480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GOX_RS06485	COG2010	Cytochrome c
GOX_RS06490	COG4993	Dehydrogenase
GOX_RS06490	COG2010	Cytochrome c
GOX_RS06495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GOX_RS06500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GOX_RS06505	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GOX_RS06515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOX_RS06540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GOX_RS06555	COG3961	Belongs to the TPP enzyme family
GOX_RS06565	COG1194	a g-specific adenine glycosylase
GOX_RS06580	COG0560	Phosphoserine phosphatase
GOX_RS06585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GOX_RS06590	COG0028	Belongs to the TPP enzyme family
GOX_RS06595	COG0440	acetolactate synthase activity
GOX_RS06600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GOX_RS06605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GOX_RS06610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GOX_RS06615	COG1846	Transcriptional regulator
GOX_RS06635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GOX_RS06640	COG0509	glycine decarboxylation via glycine cleavage system
GOX_RS06645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GOX_RS06645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GOX_RS06655	COG2608	mercury ion transmembrane transporter activity
GOX_RS06665	COG0174	glutamine synthetase
GOX_RS06680	COG0312	modulator of DNA gyrase
GOX_RS06700	COG0438	transferase activity, transferring glycosyl groups
GOX_RS06700	COG1216	Glycosyl transferase, family 2
GOX_RS06705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GOX_RS06710	COG0463	Glycosyl transferase, family 2
GOX_RS06715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GOX_RS06725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GOX_RS06730	COG0356	it plays a direct role in the translocation of protons across the membrane
GOX_RS06740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GOX_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
GOX_RS06790	COG1215	transferase activity, transferring glycosyl groups
GOX_RS06805	COG3754	Rhamnan synthesis protein F
GOX_RS06810	COG0776	regulation of translation
GOX_RS06845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOX_RS06850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GOX_RS06865	COG0753	catalase activity
GOX_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS06875	COG0477	Major facilitator Superfamily
GOX_RS06880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GOX_RS06885	COG0193	aminoacyl-tRNA hydrolase activity
GOX_RS06905	COG0012	GTP binding
GOX_RS06910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GOX_RS06915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GOX_RS06920	COG0799	negative regulation of ribosome biogenesis
GOX_RS06925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GOX_RS06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOX_RS06985	COG2188	Transcriptional regulator
GOX_RS06990	COG1228	amidohydrolase
GOX_RS06995	COG0402	S-adenosylhomocysteine deaminase activity
GOX_RS07005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GOX_RS07010	COG2986	histidine ammonia-lyase
GOX_RS07025	COG0277	FAD linked oxidase domain protein
GOX_RS07030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GOX_RS07040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GOX_RS07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOX_RS07055	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GOX_RS07065	COG1940	carbohydrate kinase activity
GOX_RS07080	COG1940	carbohydrate kinase activity
GOX_RS07090	COG1653	transport
GOX_RS07135	COG1522	sequence-specific DNA binding
GOX_RS07140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GOX_RS07150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GOX_RS07155	COG1959	2 iron, 2 sulfur cluster binding
GOX_RS07165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GOX_RS07180	COG0133	tryptophan synthase activity
GOX_RS07185	COG0159	tryptophan synthase activity
GOX_RS07195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GOX_RS07205	COG0305	Participates in initiation and elongation during chromosome replication
GOX_RS07280	COG0085	RNA polymerase activity
GOX_RS07360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GOX_RS07365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GOX_RS07370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GOX_RS07375	COG2137	regulation of response to DNA damage stimulus
GOX_RS07385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GOX_RS07390	COG0235	Class ii aldolase
GOX_RS07395	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GOX_RS07400	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GOX_RS07405	COG0196	riboflavin kinase activity
GOX_RS07425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GOX_RS07430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GOX_RS07445	COG0277	FAD linked oxidase domain protein
GOX_RS07465	COG0187	DNA topoisomerase II activity
GOX_RS07490	COG0793	Belongs to the peptidase S41A family
GOX_RS07495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GOX_RS07500	COG0758	DNA mediated transformation
GOX_RS07505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GOX_RS07510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOX_RS07515	COG0540	Belongs to the ATCase OTCase family
GOX_RS07520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GOX_RS07540	COG0658	competence protein
GOX_RS07540	COG2333	competence protein COMEC
GOX_RS07550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GOX_RS07555	COG5265	(ABC) transporter
GOX_RS07560	COG1228	amidohydrolase
GOX_RS07590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GOX_RS07595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GOX_RS07600	COG1420	regulation of RNA biosynthetic process
GOX_RS07605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GOX_RS07640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GOX_RS07645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOX_RS07660	COG1301	dicarboxylic acid transport
GOX_RS07680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GOX_RS07690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GOX_RS07700	COG2995	paraquat-inducible protein a
GOX_RS07705	COG3008	intermembrane lipid transfer
GOX_RS07720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GOX_RS07740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GOX_RS07745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GOX_RS07750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GOX_RS07755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GOX_RS07760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GOX_RS07800	COG3547	Transposase (IS116 IS110 IS902 family)
GOX_RS07835	COG0071	Belongs to the small heat shock protein (HSP20) family
GOX_RS07845	COG0583	DNA-binding transcription factor activity
GOX_RS07860	COG1280	lysine exporter protein (LysE YggA)
GOX_RS07865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GOX_RS07870	COG0473	3-isopropylmalate dehydrogenase activity
GOX_RS07880	COG0628	permease
GOX_RS07900	COG1501	Belongs to the glycosyl hydrolase 31 family
GOX_RS07965	COG0438	transferase activity, transferring glycosyl groups
GOX_RS07975	COG0247	lactate metabolic process
GOX_RS07980	COG1139	Iron-sulfur cluster binding protein
GOX_RS08000	COG2197	response regulator
GOX_RS08005	COG4585	Histidine kinase
GOX_RS08015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GOX_RS08030	COG2945	thiolester hydrolase activity
GOX_RS08040	COG1104	cysteine desulfurase activity
GOX_RS08050	COG0482	sulfurtransferase activity
GOX_RS08130	COG3177	Filamentation induced by cAMP protein fic
GOX_RS08155	COG2226	methyltransferase
GOX_RS08170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GOX_RS08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GOX_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS08240	COG2983	Belongs to the UPF0260 family
GOX_RS08275	COG1566	PFAM secretion protein HlyD family protein
GOX_RS08290	COG0484	heat shock protein binding
GOX_RS08295	COG3104	oligopeptide transport
GOX_RS08330	COG0741	lytic transglycosylase activity
GOX_RS08360	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GOX_RS08370	COG0489	protein tyrosine kinase activity
GOX_RS08385	COG0246	Mannitol dehydrogenase
GOX_RS08390	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GOX_RS08405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GOX_RS08410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GOX_RS08420	COG1285	pathogenesis
GOX_RS08425	COG0343	queuine tRNA-ribosyltransferase activity
GOX_RS08430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GOX_RS08435	COG4993	Dehydrogenase
GOX_RS08445	COG3956	TIGRFAM MazG family protein
GOX_RS08450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GOX_RS08465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GOX_RS08470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GOX_RS08485	COG0552	protein localization to endoplasmic reticulum
GOX_RS08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GOX_RS08495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GOX_RS08500	COG2226	methyltransferase
GOX_RS08505	COG0513	Belongs to the DEAD box helicase family
GOX_RS08515	COG2326	polyphosphate kinase activity
GOX_RS08520	COG4221	oxidoreductase activity
GOX_RS08525	COG1678	Uncharacterized ACR, COG1678
GOX_RS08530	COG2999	glutathione oxidoreductase activity
GOX_RS08540	COG0667	Aldo Keto reductase
GOX_RS08545	COG0542	response to heat
GOX_RS08580	COG0363	glucosamine-6-phosphate deaminase activity
GOX_RS08590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GOX_RS08660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GOX_RS08695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GOX_RS08700	COG2080	2 iron, 2 sulfur cluster binding
GOX_RS08745	COG1205	dead DEAH box helicase
GOX_RS08745	COG1111	helicase
GOX_RS08750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GOX_RS08810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GOX_RS08810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GOX_RS08815	COG1494	fructose-1,6-bisphosphatase
GOX_RS08825	COG0436	Aminotransferase
GOX_RS08835	COG0740	serine-type endopeptidase activity
GOX_RS08845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GOX_RS08850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GOX_RS08855	COG1684	flagellar biosynthetic protein fliR
GOX_RS08860	COG1987	bacterial-type flagellum assembly
GOX_RS08865	COG1677	Flagellar hook-basal body complex protein FliE
GOX_RS08870	COG1558	bacterial-type flagellum-dependent cell motility
GOX_RS08875	COG1815	bacterial-type flagellum-dependent cell motility
GOX_RS08890	COG1338	Plays a role in the flagellum-specific transport system
GOX_RS08895	COG0405	Gamma-glutamyltransferase
GOX_RS08910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GOX_RS08915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GOX_RS08920	COG0302	gtp cyclohydrolase
GOX_RS08925	COG0300	oxidoreductase activity
GOX_RS08935	COG3588	fructose-bisphosphate aldolase
GOX_RS08945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GOX_RS08950	COG0602	queuosine metabolic process
GOX_RS08980	COG0840	transmembrane signaling receptor activity
GOX_RS08990	COG0745	RESPONSE REGULATOR receiver
GOX_RS08995	COG0643	Histidine kinase
GOX_RS08995	COG2198	Histidine kinase
GOX_RS09000	COG0835	chemotaxis
GOX_RS09010	COG2201	protein-glutamate methylesterase activity
GOX_RS09015	COG0745	RESPONSE REGULATOR receiver
GOX_RS09030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GOX_RS09045	COG0741	lytic transglycosylase activity
GOX_RS09065	COG1238	metal cluster binding
GOX_RS09075	COG3409	Peptidoglycan-binding domain 1 protein
GOX_RS09075	COG0793	Belongs to the peptidase S41A family
GOX_RS09080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GOX_RS09085	COG4133	protoheme IX ABC transporter activity
GOX_RS09090	COG1126	abc transporter atp-binding protein
GOX_RS09095	COG0765	amino acid transport
GOX_RS09115	COG0542	response to heat
GOX_RS09125	COG0779	Required for maturation of 30S ribosomal subunits
GOX_RS09140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GOX_RS09145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GOX_RS09150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GOX_RS09155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GOX_RS09160	COG1185	polyribonucleotide nucleotidyltransferase activity
GOX_RS09200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GOX_RS09205	COG3158	transport of potassium into the cell
GOX_RS09210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GOX_RS09220	COG0667	Aldo Keto reductase
GOX_RS09225	COG2205	protein histidine kinase activity
GOX_RS09255	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GOX_RS09285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GOX_RS09300	COG5001	Diguanylate cyclase
GOX_RS09300	COG3300	MHYT domain
GOX_RS09310	COG0667	Aldo Keto reductase
GOX_RS09320	COG0523	cobalamin synthesis protein
GOX_RS09335	COG4191	Histidine kinase
GOX_RS09335	COG0784	Response regulator, receiver
GOX_RS09355	COG0671	phosphoesterase, PA-phosphatase related
GOX_RS09365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GOX_RS09370	COG1230	cation diffusion facilitator family transporter
GOX_RS09375	COG0693	protein deglycase activity
GOX_RS09380	COG2862	Uncharacterized protein family, UPF0114
GOX_RS09405	COG1741	Belongs to the pirin family
GOX_RS09410	COG0583	DNA-binding transcription factor activity
GOX_RS09415	COG0156	8-amino-7-oxononanoate synthase activity
GOX_RS09440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GOX_RS09445	COG4251	negative regulation of phosphorylation
GOX_RS09455	COG0114	fumarate hydratase activity
GOX_RS09480	COG3088	subunit of a heme lyase
GOX_RS09485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOX_RS09490	COG1138	Cytochrome C-type biogenesis protein
GOX_RS09495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GOX_RS09500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GOX_RS09530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GOX_RS09550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GOX_RS09560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GOX_RS09565	COG0564	pseudouridine synthase activity
GOX_RS09585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GOX_RS09585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GOX_RS09615	COG1252	NADH dehydrogenase
GOX_RS09620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GOX_RS09625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GOX_RS09630	COG0653	protein targeting
GOX_RS09635	COG0217	transcriptional regulatory protein
GOX_RS09640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GOX_RS09645	COG0632	four-way junction helicase activity
GOX_RS09650	COG2255	four-way junction helicase activity
GOX_RS09655	COG0824	Thioesterase
GOX_RS09660	COG0811	peptide transport
GOX_RS09665	COG0848	biopolymer transport protein
GOX_RS09675	COG0823	Involved in the tonB-independent uptake of proteins
GOX_RS09680	COG2885	chlorophyll binding
GOX_RS09690	COG0037	tRNA processing
GOX_RS09695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GOX_RS09700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GOX_RS09705	COG0745	RESPONSE REGULATOR receiver
GOX_RS09730	COG2309	aminopeptidase activity
GOX_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GOX_RS09765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GOX_RS09770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GOX_RS09775	COG0561	phosphatase activity
GOX_RS09780	COG0363	glucosamine-6-phosphate deaminase activity
GOX_RS09785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GOX_RS09790	COG3265	gluconokinase activity
GOX_RS09795	COG1671	Belongs to the UPF0178 family
GOX_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
GOX_RS09810	COG0693	protein deglycase activity
GOX_RS09815	COG0584	glycerophosphoryl diester phosphodiesterase
GOX_RS09835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GOX_RS09840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GOX_RS09870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GOX_RS09870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GOX_RS09880	COG0747	negative chemotaxis
GOX_RS09895	COG1570	exodeoxyribonuclease VII activity
GOX_RS09920	COG0730	response to heat
GOX_RS09950	COG0768	penicillin binding
GOX_RS09955	COG0772	Belongs to the SEDS family
GOX_RS09970	COG0752	glycyl-tRNA synthetase alpha subunit
GOX_RS09985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GOX_RS10005	COG0316	Belongs to the HesB IscA family
GOX_RS10010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GOX_RS10015	COG0018	arginyl-trna synthetase
GOX_RS10025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GOX_RS10035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GOX_RS10040	COG0805	protein transport
GOX_RS10045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GOX_RS10050	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GOX_RS10075	COG1289	transmembrane transporter activity
GOX_RS10090	COG3145	DNA-N1-methyladenine dioxygenase activity
GOX_RS10095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GOX_RS10110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GOX_RS10125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GOX_RS10130	COG0215	cysteine-tRNA ligase activity
GOX_RS10140	COG2814	Major facilitator Superfamily
GOX_RS10150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GOX_RS10180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GOX_RS10190	COG2885	chlorophyll binding
GOX_RS10190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GOX_RS10195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GOX_RS10205	COG4974	Belongs to the 'phage' integrase family
GOX_RS10210	COG0825	malonyl-CoA metabolic process
GOX_RS10215	COG1058	Belongs to the CinA family
GOX_RS10215	COG1546	Belongs to the CinA family
GOX_RS10225	COG0494	nUDIX hydrolase
GOX_RS10245	COG1862	Preprotein translocase
GOX_RS10260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GOX_RS10265	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GOX_RS10280	COG1758	RNA polymerase activity
GOX_RS10290	COG0736	holo-[acyl-carrier-protein] synthase activity
GOX_RS10295	COG0681	Belongs to the peptidase S26 family
GOX_RS10305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GOX_RS10310	COG0528	UMP kinase activity
GOX_RS10315	COG0233	cytoplasmic translational termination
GOX_RS10320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GOX_RS10330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GOX_RS10335	COG0750	zinc metalloprotease
GOX_RS10350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GOX_RS10355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GOX_RS10360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GOX_RS10365	COG3494	Protein of unknown function (DUF1009)
GOX_RS10370	COG0346	lactoylglutathione lyase activity
GOX_RS10380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GOX_RS10385	COG0594	ribonuclease P activity
GOX_RS10390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GOX_RS10395	COG0706	membrane insertase activity
GOX_RS10400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GOX_RS10405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GOX_RS10415	COG2171	N-acyltransferase activity
GOX_RS10420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOX_RS10430	COG0101	tRNA pseudouridine synthase activity
GOX_RS10435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GOX_RS10440	COG0242	peptide deformylase activity
GOX_RS10455	COG0251	oxidation-reduction process
GOX_RS10465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GOX_RS10470	COG1137	ATPase activity
GOX_RS10485	COG0517	IMP dehydrogenase activity
GOX_RS10485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GOX_RS10520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GOX_RS10520	COG2755	lipolytic protein G-D-S-L family
GOX_RS10525	COG1164	Oligoendopeptidase f
GOX_RS10530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GOX_RS10540	COG4993	Dehydrogenase
GOX_RS10550	COG0556	nucleotide-excision repair
GOX_RS10560	COG0189	ligase activity
GOX_RS10570	COG2226	methyltransferase
GOX_RS10575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GOX_RS10580	COG0109	protoheme IX farnesyltransferase activity
GOX_RS10590	COG0312	modulator of DNA gyrase
GOX_RS10595	COG0612	Peptidase, M16
GOX_RS10620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GOX_RS10625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GOX_RS10645	COG0386	Belongs to the glutathione peroxidase family
GOX_RS10650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GOX_RS10655	COG2032	superoxide dismutase activity
GOX_RS10660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GOX_RS10665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GOX_RS10670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GOX_RS10675	COG0181	hydroxymethylbilane synthase activity
GOX_RS10685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GOX_RS10705	COG1858	cytochrome C peroxidase
GOX_RS10745	COG0408	coproporphyrinogen oxidase activity
GOX_RS10750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GOX_RS10760	COG4221	oxidoreductase activity
GOX_RS10765	COG0412	Dienelactone hydrolase
GOX_RS10775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GOX_RS10780	COG0459	protein refolding
GOX_RS10805	COG2095	MarC family integral membrane protein
GOX_RS10810	COG1573	uracil-dna glycosylase
GOX_RS10815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GOX_RS10820	COG0670	Belongs to the BI1 family
GOX_RS10840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GOX_RS10860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GOX_RS10900	COG0488	(ABC) transporter
GOX_RS10905	COG0105	UTP biosynthetic process
GOX_RS10930	COG0625	glutathione transferase activity
GOX_RS10935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GOX_RS10940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GOX_RS10950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GOX_RS10965	COG2814	Major facilitator Superfamily
GOX_RS10985	COG0019	diaminopimelate decarboxylase activity
GOX_RS10990	COG0295	cytidine deaminase activity
GOX_RS11000	COG2204	response regulator
GOX_RS11020	COG0519	Catalyzes the synthesis of GMP from XMP
GOX_RS11020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GOX_RS11040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GOX_RS11045	COG0165	Argininosuccinate lyase
GOX_RS11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOX_RS11055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOX_RS11070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GOX_RS11075	COG0237	dephospho-CoA kinase activity
GOX_RS11080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GOX_RS11090	COG0438	transferase activity, transferring glycosyl groups
GOX_RS11095	COG0367	asparagine synthase
GOX_RS11100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOX_RS11125	COG1160	GTP binding
GOX_RS11130	COG2814	Major facilitator Superfamily
GOX_RS11140	COG2264	protein methyltransferase activity
GOX_RS11145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GOX_RS11155	COG3572	ergothioneine biosynthetic process
GOX_RS11165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GOX_RS11170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GOX_RS11190	COG1663	tetraacyldisaccharide 4'-kinase activity
GOX_RS11195	COG1519	Transferase
GOX_RS11210	COG0259	pyridoxamine-phosphate oxidase activity
GOX_RS11220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GOX_RS11225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GOX_RS11230	COG1764	response to oxidative stress
GOX_RS11235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GOX_RS11235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GOX_RS11240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GOX_RS11250	COG0142	geranyltranstransferase activity
GOX_RS11255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GOX_RS11260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GOX_RS11280	COG0287	Prephenate dehydrogenase
GOX_RS11280	COG1605	Chorismate mutase
GOX_RS11285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GOX_RS11290	COG1196	nuclear chromosome segregation
GOX_RS11295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GOX_RS11300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GOX_RS11310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GOX_RS11315	COG1702	phosphate starvation-inducible protein PhoH
GOX_RS11320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GOX_RS11340	COG0457	Tetratricopeptide repeat
GOX_RS11340	COG0859	PFAM glycosyl transferase family 9
GOX_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS11355	COG1329	Transcriptional regulator
GOX_RS11360	COG3781	membrane
GOX_RS11365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GOX_RS11370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GOX_RS11380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GOX_RS11385	COG0354	folic acid binding
GOX_RS11400	COG1136	(ABC) transporter
GOX_RS11430	COG0443	Heat shock 70 kDa protein
GOX_RS11435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GOX_RS11475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GOX_RS11485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOX_RS11490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GOX_RS11495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GOX_RS11505	COG0483	inositol monophosphate 1-phosphatase activity
GOX_RS11520	COG0438	transferase activity, transferring glycosyl groups
GOX_RS11545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GOX_RS11560	COG0156	8-amino-7-oxononanoate synthase activity
GOX_RS11565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOX_RS11570	COG0318	PFAM AMP-dependent synthetase and ligase
GOX_RS11605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GOX_RS11605	COG1648	precorrin-2 dehydrogenase activity
GOX_RS11610	COG2066	Belongs to the glutaminase family
GOX_RS11615	COG1914	H( )-stimulated, divalent metal cation uptake system
GOX_RS11625	COG1349	DNA-binding transcription factor activity
GOX_RS11630	COG0579	oxidoreductase
GOX_RS11635	COG0277	FAD linked oxidase domain protein
GOX_RS11650	COG1410	methionine synthase
GOX_RS11650	COG0646	methionine synthase
GOX_RS11670	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
GOX_RS11675	COG3729	General stress protein
GOX_RS11685	COG1289	transmembrane transporter activity
GOX_RS11730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GOX_RS11760	COG1620	l-lactate permease
GOX_RS11795	COG0583	DNA-binding transcription factor activity
GOX_RS11800	COG2249	NAD(P)H dehydrogenase (quinone) activity
GOX_RS11805	COG1979	alcohol dehydrogenase
GOX_RS11815	COG1012	belongs to the aldehyde dehydrogenase family
GOX_RS11830	COG1566	PFAM secretion protein HlyD family protein
GOX_RS11850	COG1802	Transcriptional regulator
GOX_RS11855	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GOX_RS11855	COG0506	proline dehydrogenase activity
GOX_RS11855	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GOX_RS11860	COG3191	aminopeptidase activity
GOX_RS11865	COG4172	Belongs to the ABC transporter superfamily
GOX_RS11870	COG0444	Belongs to the ABC transporter superfamily
GOX_RS11875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOX_RS11885	COG0747	negative chemotaxis
GOX_RS11900	COG1127	ABC transporter
GOX_RS11905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GOX_RS11910	COG0463	Glycosyl transferase, family 2
GOX_RS11915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GOX_RS11940	COG0339	signal peptide processing
GOX_RS11965	COG0583	DNA-binding transcription factor activity
GOX_RS11970	COG3384	dioxygenase
GOX_RS11975	COG2353	YceI-like domain
GOX_RS11990	COG0488	(ABC) transporter
GOX_RS12000	COG0038	chloride channel
GOX_RS12060	COG1131	(ABC) transporter
GOX_RS12065	COG1522	sequence-specific DNA binding
GOX_RS12075	COG2855	membrane
GOX_RS12090	COG1278	Cold shock
GOX_RS12095	COG1309	transcriptional regulator
GOX_RS12105	COG0306	phosphate transporter
GOX_RS12110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GOX_RS12115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GOX_RS12130	COG0356	it plays a direct role in the translocation of protons across the membrane
GOX_RS12140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GOX_RS12145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GOX_RS12150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GOX_RS12155	COG3511	phospholipase C
GOX_RS12185	COG4774	siderophore transport
GOX_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS12195	COG3842	ATPase activity
GOX_RS12215	COG1069	ribulokinase activity
GOX_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS12330	COG0583	DNA-binding transcription factor activity
GOX_RS12350	COG0523	cobalamin synthesis protein
GOX_RS12360	COG1070	Carbohydrate kinase
GOX_RS12365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GOX_RS12390	COG1129	ABC transporter
GOX_RS12395	COG1172	Belongs to the binding-protein-dependent transport system permease family
GOX_RS12400	COG2376	Dihydroxyacetone kinase
GOX_RS12420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GOX_RS12435	COG2022	thiamine diphosphate biosynthetic process
GOX_RS12445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GOX_RS12450	COG0351	phosphomethylpyrimidine kinase
GOX_RS12455	COG0738	Major facilitator superfamily
GOX_RS12460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GOX_RS12475	COG0135	phosphoribosylanthranilate isomerase activity
GOX_RS12480	COG0284	orotidine-5'-phosphate decarboxylase activity
GOX_RS12490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GOX_RS12505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GOX_RS12510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GOX_RS12530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GOX_RS12545	COG0469	pyruvate kinase activity
GOX_RS12550	COG0287	Prephenate dehydrogenase
GOX_RS12560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOX_RS12565	COG1215	transferase activity, transferring glycosyl groups
GOX_RS12570	COG1562	ergosterol biosynthetic process
GOX_RS12575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GOX_RS12585	COG1562	ergosterol biosynthetic process
GOX_RS12590	COG1233	COG1233 Phytoene dehydrogenase and related
GOX_RS12595	COG1657	PFAM Prenyltransferase squalene oxidase
GOX_RS12610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GOX_RS12630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GOX_RS12630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GOX_RS12650	COG0745	RESPONSE REGULATOR receiver
GOX_RS12665	COG0322	excinuclease ABC activity
GOX_RS12670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GOX_RS12680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GOX_RS12685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GOX_RS12695	COG0148	phosphopyruvate hydratase activity
GOX_RS12705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GOX_RS12710	COG0504	CTP synthase activity
GOX_RS12720	COG0149	triose-phosphate isomerase activity
GOX_RS12730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GOX_RS12740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GOX_RS12745	COG0134	indole-3-glycerol-phosphate synthase activity
GOX_RS12750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GOX_RS12755	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOX_RS12755	COG0022	dehydrogenase e1 component
GOX_RS12760	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOX_RS12765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOX_RS12770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GOX_RS12790	COG0741	lytic transglycosylase activity
GOX_RS12795	COG0861	Integral membrane protein TerC family
GOX_RS12800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GOX_RS12805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GOX_RS12810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GOX_RS12820	COG0047	phosphoribosylformylglycinamidine synthase activity
GOX_RS12825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GOX_RS12835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GOX_RS12845	COG0792	nuclease activity
GOX_RS12850	COG0113	porphobilinogen synthase activity
GOX_RS12855	COG0531	amino acid
GOX_RS12860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GOX_RS12875	COG0438	transferase activity, transferring glycosyl groups
GOX_RS12880	COG0513	Belongs to the DEAD box helicase family
GOX_RS13005	COG0305	Participates in initiation and elongation during chromosome replication
GOX_RS13090	COG4386	tail sheath protein
GOX_RS13130	COG3299	homolog of phage Mu protein gp47
GOX_RS13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GOX_RS13210	COG0667	Aldo Keto reductase
GOX_RS13215	COG0583	DNA-binding transcription factor activity
GOX_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
GOX_RS13270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GOX_RS13275	COG0154	amidase activity
GOX_RS13280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GOX_RS13285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GOX_RS13305	COG2264	protein methyltransferase activity
GOX_RS13310	COG0210	DNA helicase
GOX_RS13315	COG2003	Belongs to the UPF0758 family
GOX_RS13320	COG2003	Belongs to the UPF0758 family
GOX_RS13325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GOX_RS13345	COG0071	Belongs to the small heat shock protein (HSP20) family
GOX_RS13350	COG0254	rRNA binding
GOX_RS13355	COG1970	mechanosensitive ion channel activity
GOX_RS13370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GOX_RS13380	COG0488	(ABC) transporter
GOX_RS13385	COG0784	Response regulator, receiver
GOX_RS13405	COG4988	ABC transporter
GOX_RS13410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GOX_RS13430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GOX_RS13435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GOX_RS13440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GOX_RS13450	COG4221	oxidoreductase activity
GOX_RS13455	COG0837	glucose binding
GOX_RS13685	COG3728	DNA packaging
GOX_RS13685	COG5484	DNA packaging
GOX_RS13740	COG3750	Belongs to the UPF0335 family
GOX_RS13780	COG3617	BRO family, N-terminal domain
GOX_RS13870	COG0525	valine-tRNA ligase activity
GOX_RS13880	COG0129	dihydroxy-acid dehydratase activity
GOX_RS13890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOX_RS13900	COG1116	anion transmembrane transporter activity
GOX_RS13910	COG0756	dUTP diphosphatase activity
GOX_RS13915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GOX_RS13920	COG2226	methyltransferase
GOX_RS13925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GOX_RS13930	COG0268	Binds directly to 16S ribosomal RNA
GOX_RS13980	COG1278	Cold shock
GOX_RS13995	COG3920	Histidine kinase
GOX_RS13995	COG2202	Pas domain
GOX_RS14045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA