locus-tag	class	description
GAA2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GAA2_RS00010	COG0592	DNA-directed DNA polymerase activity
GAA2_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GAA2_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GAA2_RS00025	COG0187	DNA topoisomerase II activity
GAA2_RS00075	COG0254	rRNA binding
GAA2_RS00085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GAA2_RS00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GAA2_RS00100	COG0439	Biotin carboxylase
GAA2_RS00115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GAA2_RS00120	COG0705	Rhomboid family
GAA2_RS00145	COG0515	serine threonine protein kinase
GAA2_RS00150	COG0768	penicillin binding
GAA2_RS00165	COG1716	ATPase activity
GAA2_RS00170	COG1716	ATPase activity
GAA2_RS00180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GAA2_RS00190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GAA2_RS00200	COG0514	ATP-dependent DNA helicase (RecQ)
GAA2_RS00205	COG1073	alpha beta
GAA2_RS00225	COG1959	2 iron, 2 sulfur cluster binding
GAA2_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GAA2_RS00230	COG1017	nitric oxide dioxygenase activity
GAA2_RS00260	COG2188	Transcriptional regulator
GAA2_RS00265	COG0154	amidase activity
GAA2_RS00280	COG2030	dehydratase
GAA2_RS00285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAA2_RS00295	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS00300	COG2301	Belongs to the HpcH HpaI aldolase family
GAA2_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS00365	COG0243	molybdopterin cofactor binding
GAA2_RS00455	COG1793	dna ligase
GAA2_RS00465	COG3304	Inner membrane component domain
GAA2_RS00545	COG4585	Histidine kinase
GAA2_RS00555	COG0657	acetylesterase activity
GAA2_RS00560	COG0067	glutamate synthase
GAA2_RS00560	COG0069	glutamate synthase activity
GAA2_RS00560	COG0070	glutamate synthase
GAA2_RS00570	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
GAA2_RS00580	COG2501	S4 domain
GAA2_RS00585	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GAA2_RS00585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GAA2_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS00610	COG0596	Alpha beta hydrolase
GAA2_RS00665	COG2119	membrane
GAA2_RS00705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAA2_RS00745	COG1528	Iron-storage protein
GAA2_RS00750	COG1316	TRANSCRIPTIONal
GAA2_RS00770	COG0077	Prephenate dehydratase
GAA2_RS00800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GAA2_RS00810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GAA2_RS00815	COG2076	Multidrug Resistance protein
GAA2_RS00840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GAA2_RS00840	COG2146	nitrite reductase [NAD(P)H] activity
GAA2_RS00865	COG0561	phosphatase activity
GAA2_RS00895	COG1216	Glycosyl transferase, family 2
GAA2_RS00900	COG0671	phosphoesterase, PA-phosphatase related
GAA2_RS00905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GAA2_RS00910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GAA2_RS00930	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
GAA2_RS00940	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS00945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GAA2_RS00945	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GAA2_RS00945	COG3321	synthase
GAA2_RS00950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GAA2_RS00955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GAA2_RS00970	COG0783	Belongs to the Dps family
GAA2_RS01000	COG0640	Transcriptional regulator
GAA2_RS01010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS01020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS01035	COG0277	FAD linked oxidase domain protein
GAA2_RS01050	COG0656	L-ascorbic acid biosynthetic process
GAA2_RS01060	COG4172	Belongs to the ABC transporter superfamily
GAA2_RS01070	COG4166	transmembrane transport
GAA2_RS01090	COG0477	Major facilitator Superfamily
GAA2_RS01095	COG1216	Glycosyl transferase, family 2
GAA2_RS01125	COG0604	alcohol dehydrogenase
GAA2_RS01150	COG1733	regulation of RNA biosynthetic process
GAA2_RS01165	COG1131	(ABC) transporter
GAA2_RS01170	COG0598	Magnesium transport protein CorA
GAA2_RS01210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GAA2_RS01210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GAA2_RS01255	COG0287	Prephenate dehydrogenase
GAA2_RS01300	COG0300	oxidoreductase activity
GAA2_RS01315	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS01335	COG3619	membrane
GAA2_RS01370	COG0768	penicillin binding
GAA2_RS01380	COG0583	DNA-binding transcription factor activity
GAA2_RS01410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GAA2_RS01410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GAA2_RS01415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GAA2_RS01420	COG1034	ATP synthesis coupled electron transport
GAA2_RS01430	COG0649	NAD binding
GAA2_RS01440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GAA2_RS01455	COG1181	Belongs to the D-alanine--D-alanine ligase family
GAA2_RS01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GAA2_RS01475	COG0076	glutamate decarboxylase activity
GAA2_RS01485	COG4133	protoheme IX ABC transporter activity
GAA2_RS01495	COG2365	Tyrosine phosphatase family
GAA2_RS01500	COG0789	Transcriptional regulator
GAA2_RS01510	COG0343	queuine tRNA-ribosyltransferase activity
GAA2_RS01520	COG1253	flavin adenine dinucleotide binding
GAA2_RS01525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GAA2_RS01530	COG1793	dna ligase
GAA2_RS01555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GAA2_RS01560	COG5650	phosphatidylinositol metabolic process
GAA2_RS01575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GAA2_RS01605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GAA2_RS01615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GAA2_RS01625	COG3442	glutamine amidotransferase
GAA2_RS01630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GAA2_RS01635	COG0657	acetylesterase activity
GAA2_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GAA2_RS01655	COG3328	transposase activity
GAA2_RS01675	COG0183	Belongs to the thiolase family
GAA2_RS01730	COG1309	transcriptional regulator
GAA2_RS01740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GAA2_RS01745	COG0477	Major facilitator Superfamily
GAA2_RS01755	COG0477	Major facilitator Superfamily
GAA2_RS01785	COG3265	gluconokinase activity
GAA2_RS01870	COG1408	metallophosphoesterase
GAA2_RS01875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GAA2_RS01910	COG0477	Major facilitator Superfamily
GAA2_RS01915	COG2268	Band 7 protein
GAA2_RS01925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS01950	COG0494	nUDIX hydrolase
GAA2_RS01960	COG0596	Alpha beta hydrolase
GAA2_RS01970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GAA2_RS02025	COG1205	dead DEAH box helicase
GAA2_RS02025	COG1111	helicase
GAA2_RS02030	COG1278	Cold shock
GAA2_RS02040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GAA2_RS02040	COG1754	DNA topoisomerase type I activity
GAA2_RS02120	COG2154	pterin-4-alpha-carbinolamine dehydratase
GAA2_RS02130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GAA2_RS02150	COG0281	malic enzyme
GAA2_RS02175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS02180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GAA2_RS02185	COG1088	dTDP-glucose 4,6-dehydratase activity
GAA2_RS02190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GAA2_RS02220	COG0463	Glycosyl transferase, family 2
GAA2_RS02260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GAA2_RS02265	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GAA2_RS02275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS02300	COG0747	negative chemotaxis
GAA2_RS02305	COG0351	phosphomethylpyrimidine kinase
GAA2_RS02310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GAA2_RS02320	COG1021	2,3-dihydroxybenzoate-AMP ligase
GAA2_RS02325	COG1169	isochorismate synthase
GAA2_RS02365	COG5002	protein histidine kinase activity
GAA2_RS02380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GAA2_RS02420	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GAA2_RS02420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS02425	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS02440	COG0708	Exodeoxyribonuclease III
GAA2_RS02460	COG0242	peptide deformylase activity
GAA2_RS02480	COG2032	superoxide dismutase activity
GAA2_RS02485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GAA2_RS02490	COG1320	monovalent cation:proton antiporter activity
GAA2_RS02505	COG0651	ATP synthesis coupled electron transport
GAA2_RS02510	COG1006	Multisubunit Na H antiporter MnhC subunit
GAA2_RS02515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GAA2_RS02515	COG2111	Na H antiporter
GAA2_RS02545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GAA2_RS02555	COG0688	phosphatidylethanolamine metabolic process
GAA2_RS02565	COG0546	phosphoglycolate phosphatase activity
GAA2_RS02575	COG3766	membrane
GAA2_RS02580	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS02585	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS02590	COG1309	transcriptional regulator
GAA2_RS02605	COG0154	amidase activity
GAA2_RS02610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GAA2_RS02620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GAA2_RS02635	COG3275	phosphorelay sensor kinase activity
GAA2_RS02650	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GAA2_RS02680	COG0459	protein refolding
GAA2_RS02700	COG2365	Tyrosine phosphatase family
GAA2_RS02725	COG2326	polyphosphate kinase activity
GAA2_RS02740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GAA2_RS02750	COG1505	serine-type exopeptidase activity
GAA2_RS02780	COG1228	amidohydrolase
GAA2_RS02795	COG1131	(ABC) transporter
GAA2_RS02855	COG2224	Isocitrate lyase
GAA2_RS02875	COG2326	polyphosphate kinase activity
GAA2_RS02890	COG2733	membrane
GAA2_RS02910	COG0789	Transcriptional regulator
GAA2_RS02915	COG2226	methyltransferase
GAA2_RS02915	COG1073	alpha beta
GAA2_RS02920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GAA2_RS02970	COG0788	formyltetrahydrofolate deformylase activity
GAA2_RS02975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GAA2_RS03015	COG1305	Transglutaminase-like
GAA2_RS03025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GAA2_RS03055	COG2272	Belongs to the type-B carboxylesterase lipase family
GAA2_RS03075	COG0745	RESPONSE REGULATOR receiver
GAA2_RS03080	COG2205	protein histidine kinase activity
GAA2_RS03105	COG0514	ATP-dependent DNA helicase (RecQ)
GAA2_RS03115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GAA2_RS03135	COG1937	Protein conserved in bacteria
GAA2_RS03155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GAA2_RS03170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GAA2_RS03180	COG0477	Major facilitator Superfamily
GAA2_RS03190	COG0386	Belongs to the glutathione peroxidase family
GAA2_RS03195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GAA2_RS03200	COG0047	phosphoribosylformylglycinamidine synthase activity
GAA2_RS03205	COG1362	aminopeptidase activity
GAA2_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS03260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GAA2_RS03275	COG1024	Enoyl-CoA hydratase
GAA2_RS03300	COG2814	Major facilitator Superfamily
GAA2_RS03310	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS03325	COG1024	Enoyl-CoA hydratase
GAA2_RS03340	COG0531	amino acid
GAA2_RS03355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GAA2_RS03355	COG0493	'glutamate synthase
GAA2_RS03360	COG1024	Enoyl-CoA hydratase
GAA2_RS03380	COG1309	transcriptional regulator
GAA2_RS03385	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03390	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03395	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03400	COG2030	dehydratase
GAA2_RS03420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GAA2_RS03425	COG0477	Major facilitator Superfamily
GAA2_RS03440	COG2030	dehydratase
GAA2_RS03445	COG1053	succinate dehydrogenase
GAA2_RS03455	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03460	COG1024	Enoyl-CoA hydratase
GAA2_RS03460	COG1250	3-hydroxyacyl-CoA dehydrogenase
GAA2_RS03465	COG3971	2-oxopent-4-enoate hydratase activity
GAA2_RS03470	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GAA2_RS03475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GAA2_RS03520	COG1388	LysM domain
GAA2_RS03520	COG0791	NLP P60 protein
GAA2_RS03535	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03540	COG0346	lactoylglutathione lyase activity
GAA2_RS03545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GAA2_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS03565	COG3548	integral membrane protein
GAA2_RS03570	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03575	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03580	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS03585	COG1024	Enoyl-CoA hydratase
GAA2_RS03610	COG0175	sulfate reduction
GAA2_RS03620	COG1218	3'(2'),5'-bisphosphate nucleotidase
GAA2_RS03625	COG3848	Pyruvate phosphate dikinase
GAA2_RS03625	COG0574	Belongs to the PEP-utilizing enzyme family
GAA2_RS03735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GAA2_RS03750	COG0354	folic acid binding
GAA2_RS03760	COG1271	oxidase subunit
GAA2_RS03765	COG1294	oxidase, subunit
GAA2_RS03770	COG4988	ABC transporter
GAA2_RS03775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GAA2_RS03790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GAA2_RS03825	COG3328	transposase activity
GAA2_RS03835	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GAA2_RS03845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GAA2_RS03855	COG1329	Transcriptional regulator
GAA2_RS03860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GAA2_RS03900	COG0215	cysteine-tRNA ligase activity
GAA2_RS03905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GAA2_RS03915	COG2272	Belongs to the type-B carboxylesterase lipase family
GAA2_RS03955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GAA2_RS03970	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS04010	COG5002	protein histidine kinase activity
GAA2_RS04015	COG0745	RESPONSE REGULATOR receiver
GAA2_RS04070	COG1063	alcohol dehydrogenase
GAA2_RS04090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GAA2_RS04095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GAA2_RS04100	COG0181	hydroxymethylbilane synthase activity
GAA2_RS04105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GAA2_RS04105	COG1648	precorrin-2 dehydrogenase activity
GAA2_RS04135	COG3546	catalase activity
GAA2_RS04140	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS04145	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS04175	COG2963	transposase activity
GAA2_RS04180	COG2801	Transposase and inactivated derivatives
GAA2_RS04185	COG2826	transposase and inactivated derivatives, IS30 family
GAA2_RS04205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS04245	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS04440	COG2801	Transposase and inactivated derivatives
GAA2_RS04440	COG3415	Transposase
GAA2_RS04470	COG0633	Ferredoxin
GAA2_RS04485	COG5002	protein histidine kinase activity
GAA2_RS04490	COG2197	response regulator
GAA2_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS04520	COG2801	Transposase and inactivated derivatives
GAA2_RS04520	COG3415	Transposase
GAA2_RS04530	COG2026	Addiction module toxin, RelE StbE family
GAA2_RS04535	COG2161	toxin-antitoxin pair type II binding
GAA2_RS04555	COG0450	alkyl hydroperoxide reductase
GAA2_RS04625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GAA2_RS04630	COG0406	alpha-ribazole phosphatase activity
GAA2_RS04640	COG0785	Cytochrome C biogenesis protein
GAA2_RS04650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GAA2_RS04680	COG0577	efflux transmembrane transporter activity
GAA2_RS04680	COG1136	(ABC) transporter
GAA2_RS04735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS04840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS04845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAA2_RS04855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GAA2_RS04885	COG2199	diguanylate cyclase activity
GAA2_RS04885	COG2200	EAL domain
GAA2_RS04885	COG2203	Gaf domain
GAA2_RS04895	COG3268	Saccharopine dehydrogenase
GAA2_RS04900	COG3180	Ammonia monooxygenase
GAA2_RS04905	COG2226	methyltransferase
GAA2_RS04910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GAA2_RS04920	COG3340	Belongs to the peptidase S51 family
GAA2_RS04925	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS04945	COG0644	oxidoreductase
GAA2_RS04950	COG0142	geranyltranstransferase activity
GAA2_RS04955	COG0501	Belongs to the peptidase M48B family
GAA2_RS04960	COG1666	GTP binding
GAA2_RS04980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GAA2_RS04985	COG2030	dehydratase
GAA2_RS05005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GAA2_RS05015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GAA2_RS05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GAA2_RS05025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GAA2_RS05040	COG1120	ATPase activity
GAA2_RS05070	COG0395	ABC-type sugar transport system, permease component
GAA2_RS05080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GAA2_RS05085	COG1653	transport
GAA2_RS05090	COG3842	ATPase activity
GAA2_RS05120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GAA2_RS05140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS05145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS05190	COG0085	RNA polymerase activity
GAA2_RS05195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GAA2_RS05205	COG2066	Belongs to the glutaminase family
GAA2_RS05305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GAA2_RS05365	COG2267	carboxylic ester hydrolase activity
GAA2_RS05400	COG1215	transferase activity, transferring glycosyl groups
GAA2_RS05410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GAA2_RS05410	COG2755	lipolytic protein G-D-S-L family
GAA2_RS05425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GAA2_RS05430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GAA2_RS05435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GAA2_RS05445	COG0489	protein tyrosine kinase activity
GAA2_RS05465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GAA2_RS05565	COG4974	Belongs to the 'phage' integrase family
GAA2_RS05590	COG2353	YceI-like domain
GAA2_RS05610	COG0659	secondary active sulfate transmembrane transporter activity
GAA2_RS05630	COG2072	flavoprotein involved in K transport
GAA2_RS05640	COG2365	Tyrosine phosphatase family
GAA2_RS05685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS05695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS05730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GAA2_RS05735	COG1953	Uracil, thiamine, allantoin
GAA2_RS05755	COG3257	ureidoglycine aminohydrolase activity
GAA2_RS05790	COG0521	Mo-molybdopterin cofactor biosynthetic process
GAA2_RS05825	COG1278	Cold shock
GAA2_RS05835	COG2814	Major facilitator Superfamily
GAA2_RS05855	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS05865	COG0671	phosphoesterase, PA-phosphatase related
GAA2_RS05875	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS05900	COG2252	PERMEase
GAA2_RS05905	COG1846	Transcriptional regulator
GAA2_RS05950	COG0259	pyridoxamine-phosphate oxidase activity
GAA2_RS05955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GAA2_RS05990	COG1984	allophanate hydrolase subunit 2
GAA2_RS06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GAA2_RS06010	COG0545	Peptidyl-prolyl cis-trans isomerase
GAA2_RS06015	COG0415	Belongs to the DNA photolyase family
GAA2_RS06025	COG4152	abc transporter atp-binding protein
GAA2_RS06040	COG2072	flavoprotein involved in K transport
GAA2_RS06080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GAA2_RS06090	COG2094	Belongs to the DNA glycosylase MPG family
GAA2_RS06135	COG0506	proline dehydrogenase activity
GAA2_RS06140	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS06155	COG0405	Gamma-glutamyltransferase
GAA2_RS06170	COG2814	Major facilitator Superfamily
GAA2_RS06205	COG0300	oxidoreductase activity
GAA2_RS06220	COG1218	3'(2'),5'-bisphosphate nucleotidase
GAA2_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GAA2_RS06230	COG0745	RESPONSE REGULATOR receiver
GAA2_RS06235	COG2205	protein histidine kinase activity
GAA2_RS06275	COG0166	Belongs to the GPI family
GAA2_RS06300	COG4942	peptidase
GAA2_RS06305	COG0045	succinate-CoA ligase (ADP-forming) activity
GAA2_RS06360	COG0778	Nitroreductase
GAA2_RS06370	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS06375	COG1309	transcriptional regulator
GAA2_RS06385	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS06400	COG2890	protein-(glutamine-N5) methyltransferase activity
GAA2_RS06410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GAA2_RS06420	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS06435	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GAA2_RS06490	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GAA2_RS06530	COG2860	membrane
GAA2_RS06565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GAA2_RS06570	COG2146	nitrite reductase [NAD(P)H] activity
GAA2_RS06590	COG4942	peptidase
GAA2_RS06595	COG0243	molybdopterin cofactor binding
GAA2_RS06605	COG2205	protein histidine kinase activity
GAA2_RS06610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GAA2_RS06615	COG1546	Belongs to the CinA family
GAA2_RS06615	COG1058	Belongs to the CinA family
GAA2_RS06645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GAA2_RS06655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GAA2_RS06660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GAA2_RS06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GAA2_RS06730	COG2801	Transposase and inactivated derivatives
GAA2_RS06755	COG0513	Belongs to the DEAD box helicase family
GAA2_RS06795	COG0475	glutathione-regulated potassium exporter activity
GAA2_RS06830	COG0477	Major facilitator Superfamily
GAA2_RS06835	COG2235	arginine
GAA2_RS06840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GAA2_RS06845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GAA2_RS06865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GAA2_RS06890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GAA2_RS06945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS06950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS06960	COG0084	hydrolase, TatD family'
GAA2_RS06965	COG3583	domain protein
GAA2_RS06970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GAA2_RS06975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS06985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GAA2_RS06995	COG0488	(ABC) transporter
GAA2_RS07015	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS07035	COG0183	Belongs to the thiolase family
GAA2_RS07045	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS07050	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS07060	COG0183	Belongs to the thiolase family
GAA2_RS07065	COG0583	DNA-binding transcription factor activity
GAA2_RS07075	COG1024	Enoyl-CoA hydratase
GAA2_RS07085	COG0488	(ABC) transporter
GAA2_RS07090	COG1024	Enoyl-CoA hydratase
GAA2_RS07100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GAA2_RS07130	COG0193	aminoacyl-tRNA hydrolase activity
GAA2_RS07140	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
GAA2_RS07145	COG0346	lactoylglutathione lyase activity
GAA2_RS07150	COG1393	Belongs to the ArsC family
GAA2_RS07155	COG3485	protocatechuate 3,4-dioxygenase
GAA2_RS07165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GAA2_RS07180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GAA2_RS07205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GAA2_RS07215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS07220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS07225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS07240	COG1174	glycine betaine transport
GAA2_RS07250	COG1174	glycine betaine transport
GAA2_RS07265	COG3384	dioxygenase
GAA2_RS07270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GAA2_RS07270	COG4651	solute:proton antiporter activity
GAA2_RS07285	COG2847	Copper chaperone PCu(A)C
GAA2_RS07300	COG3956	TIGRFAM MazG family protein
GAA2_RS07305	COG2837	iron assimilation
GAA2_RS07320	COG3119	arylsulfatase activity
GAA2_RS07320	COG3408	Glycogen debranching enzyme
GAA2_RS07330	COG0148	phosphopyruvate hydratase activity
GAA2_RS07380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS07425	COG2011	ABC-type metal ion transport system permease component
GAA2_RS07475	COG2267	carboxylic ester hydrolase activity
GAA2_RS07485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GAA2_RS07495	COG3135	benzoate transporter
GAA2_RS07510	COG2409	Drug exporters of the RND superfamily
GAA2_RS07545	COG2409	Drug exporters of the RND superfamily
GAA2_RS07565	COG0183	Belongs to the thiolase family
GAA2_RS07570	COG2755	lipolytic protein G-D-S-L family
GAA2_RS07585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GAA2_RS07640	COG1331	Highly conserved protein containing a thioredoxin domain
GAA2_RS07645	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GAA2_RS07650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GAA2_RS07655	COG1522	sequence-specific DNA binding
GAA2_RS07660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GAA2_RS07665	COG3540	Alkaline phosphatase
GAA2_RS07690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GAA2_RS07700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GAA2_RS07715	COG1072	(Pantothenic acid kinase))
GAA2_RS07725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GAA2_RS07735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GAA2_RS07775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GAA2_RS07775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GAA2_RS07780	COG1494	fructose-1,6-bisphosphatase
GAA2_RS07800	COG1570	exodeoxyribonuclease VII activity
GAA2_RS07810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GAA2_RS07815	COG1404	Belongs to the peptidase S8 family
GAA2_RS07825	COG1674	ftsk spoiiie
GAA2_RS07835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GAA2_RS07840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GAA2_RS07845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GAA2_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS07860	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS07870	COG2508	Transcriptional regulator
GAA2_RS07870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GAA2_RS07875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS07875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS07880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GAA2_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS07900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GAA2_RS07905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS07940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GAA2_RS07950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GAA2_RS07965	COG0456	acetyltransferase
GAA2_RS07965	COG1214	PFAM Peptidase M22, glycoprotease
GAA2_RS07970	COG0456	acetyltransferase
GAA2_RS07975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GAA2_RS07980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GAA2_RS07985	COG0459	protein refolding
GAA2_RS08020	COG0516	GMP reductase activity
GAA2_RS08035	COG1122	ATPase activity
GAA2_RS08040	COG1268	BioY protein
GAA2_RS08045	COG0519	Catalyzes the synthesis of GMP from XMP
GAA2_RS08045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GAA2_RS08065	COG2197	response regulator
GAA2_RS08075	COG0515	serine threonine protein kinase
GAA2_RS08105	COG0587	DNA-directed DNA polymerase activity
GAA2_RS08110	COG1872	DUF167
GAA2_RS08115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GAA2_RS08120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GAA2_RS08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GAA2_RS08145	COG2873	o-acetylhomoserine
GAA2_RS08150	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
GAA2_RS08155	COG2814	Major facilitator Superfamily
GAA2_RS08175	COG0180	Tryptophanyl-tRNA synthetase
GAA2_RS08180	COG1295	ribonuclease BN
GAA2_RS08185	COG1686	Belongs to the peptidase S11 family
GAA2_RS08190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GAA2_RS08230	COG3328	transposase activity
GAA2_RS08245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GAA2_RS08260	COG2009	succinate dehydrogenase
GAA2_RS08285	COG1388	LysM domain
GAA2_RS08285	COG0791	NLP P60 protein
GAA2_RS08295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GAA2_RS08315	COG1473	amidohydrolase
GAA2_RS08315	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GAA2_RS08340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GAA2_RS08345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GAA2_RS08355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GAA2_RS08360	COG1201	RNA secondary structure unwinding
GAA2_RS08380	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS08410	COG2080	2 iron, 2 sulfur cluster binding
GAA2_RS08410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GAA2_RS08425	COG0477	Major facilitator Superfamily
GAA2_RS08435	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GAA2_RS08440	COG1072	(Pantothenic acid kinase))
GAA2_RS08465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GAA2_RS08470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GAA2_RS08475	COG2080	2 iron, 2 sulfur cluster binding
GAA2_RS08480	COG1252	NADH dehydrogenase
GAA2_RS08495	COG2070	2-Nitropropane dioxygenase
GAA2_RS08520	COG4770	biotin carboxylase activity
GAA2_RS08550	COG0424	maF-like protein
GAA2_RS08560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GAA2_RS08595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GAA2_RS08620	COG1316	TRANSCRIPTIONal
GAA2_RS08645	COG1595	DNA-templated transcription, initiation
GAA2_RS08650	COG5662	AntiSigma factor
GAA2_RS08655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GAA2_RS08680	COG2239	Acts as a magnesium transporter
GAA2_RS08725	COG2890	protein-(glutamine-N5) methyltransferase activity
GAA2_RS08745	COG0598	Magnesium transport protein CorA
GAA2_RS08760	COG2072	flavoprotein involved in K transport
GAA2_RS08780	COG0567	Dehydrogenase, E1 component
GAA2_RS08780	COG0508	dehydrogenase complex catalyzes the overall conversion of
GAA2_RS08785	COG1132	(ABC) transporter
GAA2_RS08795	COG0435	Glutathione S-transferase
GAA2_RS08810	COG0420	3'-5' exonuclease activity
GAA2_RS08815	COG0419	ATPase involved in DNA repair
GAA2_RS08840	COG0018	arginyl-trna synthetase
GAA2_RS08845	COG0019	diaminopimelate decarboxylase activity
GAA2_RS08850	COG0460	homoserine dehydrogenase
GAA2_RS08855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GAA2_RS08860	COG0083	homoserine kinase activity
GAA2_RS08880	COG0254	rRNA binding
GAA2_RS08885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GAA2_RS08890	COG2890	protein-(glutamine-N5) methyltransferase activity
GAA2_RS08900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GAA2_RS08915	COG0356	it plays a direct role in the translocation of protons across the membrane
GAA2_RS08935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GAA2_RS08940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GAA2_RS08945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GAA2_RS08985	COG1454	alcohol dehydrogenase
GAA2_RS08990	COG4585	Histidine kinase
GAA2_RS08995	COG2197	response regulator
GAA2_RS09000	COG2226	methyltransferase
GAA2_RS09025	COG2066	Belongs to the glutaminase family
GAA2_RS09025	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GAA2_RS09030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GAA2_RS09040	COG0346	lactoylglutathione lyase activity
GAA2_RS09045	COG0183	Belongs to the thiolase family
GAA2_RS09060	COG2223	nitrite transmembrane transporter activity
GAA2_RS09080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GAA2_RS09085	COG0366	Alpha amylase catalytic
GAA2_RS09095	COG1335	isochorismatase
GAA2_RS09100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GAA2_RS09115	COG3191	aminopeptidase activity
GAA2_RS09140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GAA2_RS09145	COG1234	tRNA 3'-trailer cleavage
GAA2_RS09150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GAA2_RS09155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GAA2_RS09200	COG1022	Amp-dependent synthetase and ligase
GAA2_RS09235	COG0736	holo-[acyl-carrier-protein] synthase activity
GAA2_RS09260	COG1376	ErfK ybiS ycfS ynhG family protein
GAA2_RS09290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GAA2_RS09295	COG1116	anion transmembrane transporter activity
GAA2_RS09300	COG1053	succinate dehydrogenase
GAA2_RS09320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GAA2_RS09325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GAA2_RS09335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GAA2_RS09345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GAA2_RS09350	COG0483	inositol monophosphate 1-phosphatase activity
GAA2_RS09355	COG0107	imidazoleglycerol-phosphate synthase activity
GAA2_RS09360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GAA2_RS09370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GAA2_RS09390	COG0159	tryptophan synthase activity
GAA2_RS09395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GAA2_RS09400	COG2826	transposase and inactivated derivatives, IS30 family
GAA2_RS09405	COG0067	glutamate synthase
GAA2_RS09405	COG0070	glutamate synthase
GAA2_RS09405	COG0069	glutamate synthase activity
GAA2_RS09420	COG1946	Acyl-CoA thioesterase
GAA2_RS09455	COG4303	Ethanolamine ammonia lyase large subunit
GAA2_RS09460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GAA2_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS09475	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS09495	COG3360	Dodecin
GAA2_RS09500	COG3012	SEC-C Motif Domain Protein
GAA2_RS09510	COG0402	S-adenosylhomocysteine deaminase activity
GAA2_RS09535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GAA2_RS09560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GAA2_RS09570	COG2226	methyltransferase
GAA2_RS09575	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GAA2_RS09580	COG3454	Phosphonate metabolism
GAA2_RS09585	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GAA2_RS09590	COG4778	phosphonate C-P lyase system protein PhnL
GAA2_RS09595	COG4107	phosphonate C-P lyase system protein PhnK
GAA2_RS09600	COG3627	carbon phosphorus lyase activity
GAA2_RS09605	COG3626	phosphonate metabolism
GAA2_RS09615	COG3624	Phosphonate C-P lyase system protein PhnG
GAA2_RS09620	COG2188	Transcriptional regulator
GAA2_RS09625	COG3639	organic phosphonate transmembrane transporter activity
GAA2_RS09630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GAA2_RS09645	COG2801	Transposase and inactivated derivatives
GAA2_RS09695	COG1053	succinate dehydrogenase
GAA2_RS09720	COG0683	leucine binding
GAA2_RS09740	COG1172	Belongs to the binding-protein-dependent transport system permease family
GAA2_RS09760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GAA2_RS09765	COG0765	amino acid transport
GAA2_RS09770	COG1126	abc transporter atp-binding protein
GAA2_RS09775	COG2226	methyltransferase
GAA2_RS09785	COG2890	protein-(glutamine-N5) methyltransferase activity
GAA2_RS09805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GAA2_RS09820	COG0237	dephospho-CoA kinase activity
GAA2_RS09820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GAA2_RS09845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GAA2_RS09860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS09870	COG3973	AAA domain
GAA2_RS09885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS09910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GAA2_RS09915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GAA2_RS09920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GAA2_RS09930	COG2267	carboxylic ester hydrolase activity
GAA2_RS09940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GAA2_RS09945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GAA2_RS09945	COG0072	phenylalanine-tRNA ligase activity
GAA2_RS09955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GAA2_RS09960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GAA2_RS09965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GAA2_RS09970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GAA2_RS09975	COG1438	arginine binding
GAA2_RS09980	COG0137	argininosuccinate synthase activity
GAA2_RS09985	COG0165	Argininosuccinate lyase
GAA2_RS09995	COG2835	tetraacyldisaccharide 4'-kinase activity
GAA2_RS10000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GAA2_RS10020	COG0647	UMP catabolic process
GAA2_RS10035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GAA2_RS10055	COG0504	CTP synthase activity
GAA2_RS10060	COG0494	nUDIX hydrolase
GAA2_RS10080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GAA2_RS10090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GAA2_RS10095	COG1160	GTP binding
GAA2_RS10110	COG0287	Prephenate dehydrogenase
GAA2_RS10115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GAA2_RS10115	COG0512	Glutamine amidotransferase of anthranilate synthase
GAA2_RS10120	COG1605	Chorismate mutase
GAA2_RS10165	COG0601	transmembrane transport
GAA2_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GAA2_RS10195	COG0640	Transcriptional regulator
GAA2_RS10200	COG2030	dehydratase
GAA2_RS10215	COG0028	Belongs to the TPP enzyme family
GAA2_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS10310	COG2326	polyphosphate kinase activity
GAA2_RS10335	COG0653	protein targeting
GAA2_RS10350	COG1716	ATPase activity
GAA2_RS10370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GAA2_RS10370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GAA2_RS10380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GAA2_RS10390	COG1253	flavin adenine dinucleotide binding
GAA2_RS10395	COG1253	flavin adenine dinucleotide binding
GAA2_RS10405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GAA2_RS10425	COG0831	urea catabolic process
GAA2_RS10430	COG0832	Belongs to the urease beta subunit family
GAA2_RS10435	COG0804	urea catabolic process
GAA2_RS10445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GAA2_RS10455	COG1252	NADH dehydrogenase
GAA2_RS10475	COG1074	ATP-dependent DNA helicase activity
GAA2_RS10480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GAA2_RS10485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GAA2_RS10490	COG0326	Molecular chaperone. Has ATPase activity
GAA2_RS10510	COG1024	Enoyl-CoA hydratase
GAA2_RS10520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GAA2_RS10570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GAA2_RS10595	COG3467	pyridoxamine 5'-phosphate
GAA2_RS10635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GAA2_RS10645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GAA2_RS10665	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS10675	COG0183	Belongs to the thiolase family
GAA2_RS10680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS10700	COG3336	cytochrome c oxidase
GAA2_RS10710	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GAA2_RS10715	COG2801	Transposase and inactivated derivatives
GAA2_RS10725	COG4584	PFAM Integrase catalytic
GAA2_RS10730	COG1484	DNA-dependent DNA replication
GAA2_RS10750	COG0531	amino acid
GAA2_RS10820	COG4974	Belongs to the 'phage' integrase family
GAA2_RS10905	COG2205	protein histidine kinase activity
GAA2_RS10910	COG0745	RESPONSE REGULATOR receiver
GAA2_RS10915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GAA2_RS10955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAA2_RS10960	COG0640	Transcriptional regulator
GAA2_RS10965	COG0798	PFAM Bile acid sodium symporter
GAA2_RS10975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAA2_RS10985	COG2072	flavoprotein involved in K transport
GAA2_RS10990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GAA2_RS11000	COG0640	Transcriptional regulator
GAA2_RS11025	COG2072	flavoprotein involved in K transport
GAA2_RS11040	COG2217	Heavy metal translocating P-type atpase
GAA2_RS11045	COG1937	Protein conserved in bacteria
GAA2_RS11085	COG2755	lipolytic protein G-D-S-L family
GAA2_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS11110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GAA2_RS11115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GAA2_RS11120	COG0022	dehydrogenase e1 component
GAA2_RS11120	COG0508	dehydrogenase complex catalyzes the overall conversion of
GAA2_RS11125	COG0508	dehydrogenase complex catalyzes the overall conversion of
GAA2_RS11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GAA2_RS11140	COG0330	HflC and HflK could
GAA2_RS11145	COG0589	response to stress
GAA2_RS11190	COG0069	glutamate synthase activity
GAA2_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS11230	COG0028	Belongs to the TPP enzyme family
GAA2_RS11235	COG4948	Mandelate Racemase Muconate Lactonizing
GAA2_RS11240	COG0247	lactate metabolic process
GAA2_RS11240	COG0277	FAD linked oxidase domain protein
GAA2_RS11250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GAA2_RS11260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GAA2_RS11265	COG1064	alcohol dehydrogenase
GAA2_RS11275	COG1295	ribonuclease BN
GAA2_RS11305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS11310	COG2072	flavoprotein involved in K transport
GAA2_RS11315	COG0351	phosphomethylpyrimidine kinase
GAA2_RS11320	COG1063	alcohol dehydrogenase
GAA2_RS11335	COG1573	uracil-dna glycosylase
GAA2_RS11390	COG0477	Major facilitator Superfamily
GAA2_RS11395	COG5001	Diguanylate cyclase
GAA2_RS11395	COG3300	MHYT domain
GAA2_RS11400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GAA2_RS11415	COG2826	transposase and inactivated derivatives, IS30 family
GAA2_RS11425	COG1131	(ABC) transporter
GAA2_RS11430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GAA2_RS11440	COG0386	Belongs to the glutathione peroxidase family
GAA2_RS11460	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS11495	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS11505	COG1024	Enoyl-CoA hydratase
GAA2_RS11575	COG3209	COG3209 Rhs family protein
GAA2_RS11590	COG0739	heme binding
GAA2_RS11590	COG0741	lytic transglycosylase activity
GAA2_RS11590	COG1196	nuclear chromosome segregation
GAA2_RS11655	COG4584	PFAM Integrase catalytic
GAA2_RS11660	COG1484	DNA-dependent DNA replication
GAA2_RS11705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GAA2_RS11775	COG1484	DNA-dependent DNA replication
GAA2_RS11780	COG4584	PFAM Integrase catalytic
GAA2_RS11820	COG1201	RNA secondary structure unwinding
GAA2_RS11825	COG4584	PFAM Integrase catalytic
GAA2_RS11830	COG1484	DNA-dependent DNA replication
GAA2_RS11840	COG1401	restriction endodeoxyribonuclease activity
GAA2_RS11880	COG2826	transposase and inactivated derivatives, IS30 family
GAA2_RS11945	COG2072	flavoprotein involved in K transport
GAA2_RS11955	COG2144	transferase activity, transferring acyl groups
GAA2_RS11970	COG0697	spore germination
GAA2_RS11980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS12000	COG5650	phosphatidylinositol metabolic process
GAA2_RS12005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GAA2_RS12005	COG1017	nitric oxide dioxygenase activity
GAA2_RS12020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GAA2_RS12035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GAA2_RS12040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GAA2_RS12095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GAA2_RS12140	COG0300	oxidoreductase activity
GAA2_RS12175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GAA2_RS12180	COG2378	regulation of single-species biofilm formation
GAA2_RS12190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GAA2_RS12195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GAA2_RS12200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GAA2_RS12215	COG0058	SHG alpha-glucan phosphorylase activity
GAA2_RS12220	COG0842	Transport permease protein
GAA2_RS12220	COG1716	ATPase activity
GAA2_RS12220	COG1131	(ABC) transporter
GAA2_RS12225	COG1222	aaa ATPase
GAA2_RS12245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GAA2_RS12250	COG0140	phosphoribosyl-ATP diphosphatase activity
GAA2_RS12265	COG1546	Belongs to the CinA family
GAA2_RS12265	COG1058	Belongs to the CinA family
GAA2_RS12275	COG0477	Major facilitator Superfamily
GAA2_RS12285	COG1227	inorganic diphosphatase activity
GAA2_RS12290	COG1024	Enoyl-CoA hydratase
GAA2_RS12295	COG1410	methionine synthase
GAA2_RS12295	COG0646	methionine synthase
GAA2_RS12315	COG0215	cysteine-tRNA ligase activity
GAA2_RS12335	COG1968	undecaprenyl-diphosphatase activity
GAA2_RS12350	COG0167	dihydroorotate dehydrogenase activity
GAA2_RS12360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GAA2_RS12370	COG0668	transmembrane transport
GAA2_RS12430	COG3415	Transposase
GAA2_RS12430	COG2801	Transposase and inactivated derivatives
GAA2_RS12450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GAA2_RS12455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GAA2_RS12475	COG0714	Associated with various cellular activities
GAA2_RS12480	COG3883	PFAM NLP P60 protein
GAA2_RS12480	COG0791	NLP P60 protein
GAA2_RS12490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GAA2_RS12495	COG1309	transcriptional regulator
GAA2_RS12510	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS12515	COG0488	(ABC) transporter
GAA2_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS12555	COG2151	metal-sulfur cluster biosynthetic enzyme
GAA2_RS12560	COG0822	iron-sulfur transferase activity
GAA2_RS12570	COG0396	ATPase activity
GAA2_RS12605	COG1612	heme a metabolic process
GAA2_RS12620	COG0109	protoheme IX farnesyltransferase activity
GAA2_RS12630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GAA2_RS12655	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GAA2_RS12665	COG0149	triose-phosphate isomerase activity
GAA2_RS12670	COG0126	phosphoglycerate kinase activity
GAA2_RS12675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GAA2_RS12695	COG0322	excinuclease ABC activity
GAA2_RS12710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS12710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS12745	COG0640	Transcriptional regulator
GAA2_RS12755	COG1309	transcriptional regulator
GAA2_RS12770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GAA2_RS12780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GAA2_RS12790	COG1758	RNA polymerase activity
GAA2_RS12795	COG0194	GDP metabolic process
GAA2_RS12815	COG0505	Belongs to the CarA family
GAA2_RS12830	COG0540	Belongs to the ATCase OTCase family
GAA2_RS12835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GAA2_RS12840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GAA2_RS12845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GAA2_RS12850	COG0006	proline dipeptidase activity
GAA2_RS12870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GAA2_RS12880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GAA2_RS12890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GAA2_RS12895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GAA2_RS12940	COG0300	oxidoreductase activity
GAA2_RS12955	COG0124	histidyl-tRNA synthetase
GAA2_RS12970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GAA2_RS12975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GAA2_RS12980	COG0747	negative chemotaxis
GAA2_RS12985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GAA2_RS13000	COG2255	four-way junction helicase activity
GAA2_RS13005	COG0632	four-way junction helicase activity
GAA2_RS13010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GAA2_RS13015	COG0217	transcriptional regulatory protein
GAA2_RS13025	COG1946	Acyl-CoA thioesterase
GAA2_RS13045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GAA2_RS13055	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS13060	COG1560	Kdo2-lipid A biosynthetic process
GAA2_RS13075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GAA2_RS13095	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS13095	COG1454	alcohol dehydrogenase
GAA2_RS13130	COG4974	Belongs to the 'phage' integrase family
GAA2_RS13165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS13170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GAA2_RS13195	COG0446	pyridine nucleotide-disulphide oxidoreductase
GAA2_RS13195	COG1902	pentaerythritol trinitrate reductase activity
GAA2_RS13200	COG1131	(ABC) transporter
GAA2_RS13205	COG3559	Exporter of polyketide antibiotics
GAA2_RS13215	COG2124	cytochrome p450
GAA2_RS13220	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS13225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAA2_RS13235	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS13245	COG2072	flavoprotein involved in K transport
GAA2_RS13250	COG2897	thiosulfate sulfurtransferase activity
GAA2_RS13260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GAA2_RS13280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAA2_RS13290	COG3253	May function as heme-dependent peroxidase
GAA2_RS13300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GAA2_RS13310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GAA2_RS13320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GAA2_RS13325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GAA2_RS13330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GAA2_RS13335	COG0531	amino acid
GAA2_RS13340	COG0569	domain protein
GAA2_RS13370	COG0756	dUTP diphosphatase activity
GAA2_RS13405	COG0730	response to heat
GAA2_RS13445	COG0123	including yeast histone deacetylase and acetoin utilization protein
GAA2_RS13480	COG0450	alkyl hydroperoxide reductase
GAA2_RS13485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GAA2_RS13490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GAA2_RS13495	COG1643	Atp-dependent helicase
GAA2_RS13510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GAA2_RS13515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GAA2_RS13530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GAA2_RS13530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GAA2_RS13530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GAA2_RS13540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GAA2_RS13550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GAA2_RS13560	COG1196	nuclear chromosome segregation
GAA2_RS13570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GAA2_RS13575	COG1126	abc transporter atp-binding protein
GAA2_RS13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GAA2_RS13585	COG0765	amino acid transport
GAA2_RS13590	COG0765	amino acid transport
GAA2_RS13595	COG2137	regulation of response to DNA damage stimulus
GAA2_RS13600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GAA2_RS13615	COG1842	Phage shock protein A
GAA2_RS13620	COG1396	sequence-specific DNA binding
GAA2_RS13630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GAA2_RS13655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GAA2_RS13660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GAA2_RS13665	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GAA2_RS13680	COG3214	Protein conserved in bacteria
GAA2_RS13690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GAA2_RS13785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GAA2_RS13790	COG1522	sequence-specific DNA binding
GAA2_RS13795	COG0686	Belongs to the AlaDH PNT family
GAA2_RS13810	COG1185	polyribonucleotide nucleotidyltransferase activity
GAA2_RS13815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GAA2_RS13835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GAA2_RS13845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GAA2_RS13855	COG0534	Mate efflux family protein
GAA2_RS13860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GAA2_RS13865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GAA2_RS13885	COG0779	Required for maturation of 30S ribosomal subunits
GAA2_RS13900	COG0442	prolyl-tRNA aminoacylation
GAA2_RS13905	COG3022	response to hydroperoxide
GAA2_RS13915	COG1648	precorrin-2 dehydrogenase activity
GAA2_RS13915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GAA2_RS13960	COG0579	oxidoreductase
GAA2_RS13975	COG0596	Alpha beta hydrolase
GAA2_RS13995	COG4558	Periplasmic binding protein
GAA2_RS14000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GAA2_RS14005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GAA2_RS14020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GAA2_RS14030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GAA2_RS14045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GAA2_RS14065	COG0528	UMP kinase activity
GAA2_RS14075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS14080	COG0477	Major facilitator Superfamily
GAA2_RS14085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GAA2_RS14090	COG0052	Belongs to the universal ribosomal protein uS2 family
GAA2_RS14130	COG0778	Nitroreductase
GAA2_RS14155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GAA2_RS14160	COG0681	Belongs to the peptidase S26 family
GAA2_RS14185	COG0336	Belongs to the RNA methyltransferase TrmD family
GAA2_RS14190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GAA2_RS14200	COG0228	four-way junction DNA binding
GAA2_RS14210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GAA2_RS14215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GAA2_RS14240	COG1254	Belongs to the acylphosphatase family
GAA2_RS14255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GAA2_RS14260	COG0571	ribonuclease III activity
GAA2_RS14280	COG0742	ribosomal rna small subunit methyltransferase
GAA2_RS14285	COG0456	acetyltransferase
GAA2_RS14295	COG1917	Cupin 2, conserved barrel domain protein
GAA2_RS14310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GAA2_RS14325	COG1530	ribonuclease E activity
GAA2_RS14330	COG0105	UTP biosynthetic process
GAA2_RS14345	COG0285	dihydrofolate synthase activity
GAA2_RS14350	COG0525	valine-tRNA ligase activity
GAA2_RS14370	COG0740	serine-type endopeptidase activity
GAA2_RS14375	COG0740	serine-type endopeptidase activity
GAA2_RS14380	COG0544	peptidyl-prolyl cis-trans isomerase activity
GAA2_RS14405	COG1376	ErfK ybiS ycfS ynhG family protein
GAA2_RS14440	COG1309	transcriptional regulator
GAA2_RS14450	COG4565	transcriptional regulatory protein
GAA2_RS14460	COG1301	dicarboxylic acid transport
GAA2_RS14470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GAA2_RS14490	COG0366	Alpha amylase catalytic
GAA2_RS14500	COG0824	Thioesterase
GAA2_RS14505	COG0243	molybdopterin cofactor binding
GAA2_RS14510	COG2902	Dehydrogenase
GAA2_RS14520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GAA2_RS14520	COG4124	Belongs to the glycosyl hydrolase 26 family
GAA2_RS14530	COG1215	transferase activity, transferring glycosyl groups
GAA2_RS14535	COG1366	Belongs to the anti-sigma-factor antagonist family
GAA2_RS14550	COG1605	Chorismate mutase
GAA2_RS14555	COG3336	cytochrome c oxidase
GAA2_RS14650	COG2233	PERMEase
GAA2_RS14655	COG1695	Transcriptional regulator
GAA2_RS14660	COG1902	pentaerythritol trinitrate reductase activity
GAA2_RS14660	COG0446	pyridine nucleotide-disulphide oxidoreductase
GAA2_RS14665	COG4221	oxidoreductase activity
GAA2_RS14670	COG0433	COG0433 Predicted ATPase
GAA2_RS14675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GAA2_RS14710	COG2217	Heavy metal translocating P-type atpase
GAA2_RS14735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GAA2_RS14770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GAA2_RS14775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GAA2_RS14780	COG0156	8-amino-7-oxononanoate synthase activity
GAA2_RS14785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GAA2_RS14795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GAA2_RS14795	COG2755	lipolytic protein G-D-S-L family
GAA2_RS14845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS14850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS14890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GAA2_RS14905	COG0252	asparaginase activity
GAA2_RS14925	COG0640	Transcriptional regulator
GAA2_RS14935	COG1595	DNA-templated transcription, initiation
GAA2_RS14940	COG1252	NADH dehydrogenase
GAA2_RS14945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GAA2_RS14965	COG1799	cell septum assembly
GAA2_RS14975	COG1496	oxidoreductase activity
GAA2_RS14980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GAA2_RS14985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GAA2_RS14990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GAA2_RS15005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GAA2_RS15025	COG0768	penicillin binding
GAA2_RS15075	COG0142	geranyltranstransferase activity
GAA2_RS15095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GAA2_RS15115	COG1940	carbohydrate kinase activity
GAA2_RS15140	COG1022	Amp-dependent synthetase and ligase
GAA2_RS15150	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS15165	COG0791	NLP P60 protein
GAA2_RS15180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GAA2_RS15190	COG1845	cytochrome c oxidase, subunit III
GAA2_RS15205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GAA2_RS15220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GAA2_RS15230	COG3415	Transposase
GAA2_RS15230	COG2801	Transposase and inactivated derivatives
GAA2_RS15240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GAA2_RS15260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GAA2_RS15265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GAA2_RS15270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GAA2_RS15280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GAA2_RS15295	COG0321	lipoyl(octanoyl) transferase activity
GAA2_RS15300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GAA2_RS15315	COG2801	Transposase and inactivated derivatives
GAA2_RS15315	COG3415	Transposase
GAA2_RS15320	COG0174	glutamine synthetase
GAA2_RS15340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GAA2_RS15345	COG0174	glutamine synthetase
GAA2_RS15350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GAA2_RS15365	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GAA2_RS15415	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GAA2_RS15440	COG0702	epimerase
GAA2_RS15470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GAA2_RS15485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GAA2_RS15515	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS15525	COG1309	transcriptional regulator
GAA2_RS15540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GAA2_RS15570	COG1802	Transcriptional regulator
GAA2_RS15585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GAA2_RS15585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GAA2_RS15595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GAA2_RS15600	COG1278	Cold shock
GAA2_RS15605	COG0423	glycine-tRNA ligase activity
GAA2_RS15610	COG2234	aminopeptidase activity
GAA2_RS15630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GAA2_RS15635	COG1381	Involved in DNA repair and RecF pathway recombination
GAA2_RS15640	COG0469	pyruvate kinase activity
GAA2_RS15665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GAA2_RS15685	COG0484	heat shock protein binding
GAA2_RS15735	COG3387	PFAM Glycoside hydrolase 15-related
GAA2_RS15740	COG3842	ATPase activity
GAA2_RS15745	COG4208	sulfate ABC transporter
GAA2_RS15750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GAA2_RS15755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GAA2_RS15760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GAA2_RS15765	COG0339	signal peptide processing
GAA2_RS15770	COG0481	GTPase activity
GAA2_RS15790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GAA2_RS15795	COG0745	RESPONSE REGULATOR receiver
GAA2_RS15800	COG2205	protein histidine kinase activity
GAA2_RS15805	COG1305	Transglutaminase-like
GAA2_RS15825	COG0268	Binds directly to 16S ribosomal RNA
GAA2_RS15865	COG2755	lipolytic protein G-D-S-L family
GAA2_RS15870	COG0406	alpha-ribazole phosphatase activity
GAA2_RS15875	COG0799	negative regulation of ribosome biogenesis
GAA2_RS15880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GAA2_RS15895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GAA2_RS15905	COG1937	Protein conserved in bacteria
GAA2_RS15920	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GAA2_RS15930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GAA2_RS15935	COG1461	Dihydroxyacetone kinase
GAA2_RS15940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GAA2_RS15945	COG1024	Enoyl-CoA hydratase
GAA2_RS15950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GAA2_RS15955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GAA2_RS15980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GAA2_RS15985	COG1920	GTP binding
GAA2_RS15990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GAA2_RS15995	COG0494	nUDIX hydrolase
GAA2_RS15995	COG0406	alpha-ribazole phosphatase activity
GAA2_RS16005	COG0066	3-isopropylmalate dehydratase activity
GAA2_RS16010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GAA2_RS16035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GAA2_RS16045	COG0179	Fumarylacetoacetate (FAA) hydrolase
GAA2_RS16050	COG2271	Major facilitator Superfamily
GAA2_RS16055	COG0473	3-isopropylmalate dehydrogenase activity
GAA2_RS16085	COG0440	acetolactate synthase activity
GAA2_RS16100	COG2239	Acts as a magnesium transporter
GAA2_RS16105	COG0129	dihydroxy-acid dehydratase activity
GAA2_RS16120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GAA2_RS16135	COG2197	response regulator
GAA2_RS16140	COG4585	Histidine kinase
GAA2_RS16155	COG0154	amidase activity
GAA2_RS16160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GAA2_RS16170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GAA2_RS16175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GAA2_RS16190	COG0482	sulfurtransferase activity
GAA2_RS16215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GAA2_RS16225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GAA2_RS16265	COG0110	maltose O-acetyltransferase activity
GAA2_RS16270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GAA2_RS16285	COG2226	methyltransferase
GAA2_RS16290	COG1024	Enoyl-CoA hydratase
GAA2_RS16305	COG1119	ATPase activity
GAA2_RS16310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS16315	COG2365	Tyrosine phosphatase family
GAA2_RS16340	COG3830	Belongs to the UPF0237 family
GAA2_RS16340	COG0560	Phosphoserine phosphatase
GAA2_RS16365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GAA2_RS16375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GAA2_RS16395	COG1053	succinate dehydrogenase
GAA2_RS16395	COG3976	FMN-binding domain protein
GAA2_RS16395	COG0431	NADPH-dependent FMN reductase
GAA2_RS16405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GAA2_RS16420	COG1482	cell wall glycoprotein biosynthetic process
GAA2_RS16450	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GAA2_RS16450	COG0778	Nitroreductase
GAA2_RS16465	COG0297	glycogen (starch) synthase activity
GAA2_RS16485	COG0463	Glycosyl transferase, family 2
GAA2_RS16495	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS16500	COG1611	Belongs to the LOG family
GAA2_RS16505	COG1611	Belongs to the LOG family
GAA2_RS16530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GAA2_RS16545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GAA2_RS16550	COG2072	flavoprotein involved in K transport
GAA2_RS16555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GAA2_RS16565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GAA2_RS16570	COG0747	negative chemotaxis
GAA2_RS16575	COG1217	gtp-binding protein TYPA
GAA2_RS16590	COG3842	ATPase activity
GAA2_RS16655	COG0628	permease
GAA2_RS16665	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS16725	COG2801	Transposase and inactivated derivatives
GAA2_RS16745	COG1388	LysM domain
GAA2_RS16770	COG0410	ABC transporter
GAA2_RS16785	COG0559	Belongs to the binding-protein-dependent transport system permease family
GAA2_RS16805	COG2814	Major facilitator Superfamily
GAA2_RS16820	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GAA2_RS16825	COG2207	Transcriptional regulator
GAA2_RS16825	COG3708	Transcriptional regulator
GAA2_RS16830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GAA2_RS16855	COG0640	Transcriptional regulator
GAA2_RS16865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAA2_RS16870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAA2_RS16875	COG0798	PFAM Bile acid sodium symporter
GAA2_RS16880	COG0640	Transcriptional regulator
GAA2_RS16885	COG0346	lactoylglutathione lyase activity
GAA2_RS16890	COG2824	Alkylphosphonate utilization operon protein PhnA
GAA2_RS16900	COG0012	GTP binding
GAA2_RS16925	COG1322	Protein conserved in bacteria
GAA2_RS16935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GAA2_RS16990	COG3384	dioxygenase
GAA2_RS17005	COG0488	(ABC) transporter
GAA2_RS17035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GAA2_RS17045	COG2132	Multicopper oxidase
GAA2_RS17080	COG0033	Phosphoglucomutase
GAA2_RS17090	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS17095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAA2_RS17105	COG1121	(ABC) transporter
GAA2_RS17110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GAA2_RS17135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GAA2_RS17140	COG2177	Part of the ABC transporter FtsEX involved in
GAA2_RS17145	COG2884	Cell division ATP-binding protein ftsE
GAA2_RS17155	COG0668	transmembrane transport
GAA2_RS17160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GAA2_RS17170	COG0483	inositol monophosphate 1-phosphatase activity
GAA2_RS17185	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS17190	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS17195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GAA2_RS17200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GAA2_RS17230	COG4585	Histidine kinase
GAA2_RS17235	COG2197	response regulator
GAA2_RS17275	COG1615	UPF0182 protein
GAA2_RS17300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GAA2_RS17330	COG0210	DNA helicase
GAA2_RS17340	COG0596	Alpha beta hydrolase
GAA2_RS17345	COG3695	enzyme binding
GAA2_RS17365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GAA2_RS17365	COG2146	nitrite reductase [NAD(P)H] activity
GAA2_RS17370	COG2223	nitrite transmembrane transporter activity
GAA2_RS17405	COG0513	Belongs to the DEAD box helicase family
GAA2_RS17415	COG1192	Involved in chromosome partitioning
GAA2_RS17425	COG1597	lipid kinase activity
GAA2_RS17430	COG2223	nitrite transmembrane transporter activity
GAA2_RS17445	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GAA2_RS17455	COG1595	DNA-templated transcription, initiation
GAA2_RS17460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GAA2_RS17480	COG1136	(ABC) transporter
GAA2_RS17545	COG1051	belongs to the nudix hydrolase family
GAA2_RS17550	COG0436	Aminotransferase
GAA2_RS17600	COG0459	protein refolding
GAA2_RS17610	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS17620	COG3402	PFAM membrane-flanked domain
GAA2_RS17635	COG1309	transcriptional regulator
GAA2_RS17660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GAA2_RS17705	COG0653	protein targeting
GAA2_RS17710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GAA2_RS17725	COG5002	protein histidine kinase activity
GAA2_RS17750	COG0531	amino acid
GAA2_RS17760	COG0733	neurotransmitter:sodium symporter activity
GAA2_RS17815	COG0586	Pfam SNARE associated Golgi protein
GAA2_RS17845	COG0202	RNA polymerase activity
GAA2_RS17850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GAA2_RS17855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GAA2_RS17865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GAA2_RS17870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GAA2_RS17875	COG1950	PFAM Membrane protein of
GAA2_RS17890	COG1490	D-aminoacyl-tRNA deacylase activity
GAA2_RS17895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GAA2_RS17900	COG3842	ATPase activity
GAA2_RS17920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GAA2_RS17925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GAA2_RS17935	COG0563	adenylate kinase activity
GAA2_RS17945	COG0200	Binds to the 23S rRNA
GAA2_RS17955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GAA2_RS17960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GAA2_RS17970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GAA2_RS17975	COG2133	pyrroloquinoline quinone binding
GAA2_RS17990	COG1140	nitrate reductase beta subunit
GAA2_RS18045	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS18100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GAA2_RS18125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GAA2_RS18140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GAA2_RS18170	COG3328	transposase activity
GAA2_RS18210	COG0463	Glycosyl transferase, family 2
GAA2_RS18215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS18245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS18295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GAA2_RS18305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GAA2_RS18315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GAA2_RS18320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GAA2_RS18325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GAA2_RS18330	COG0089	rRNA binding
GAA2_RS18335	COG0088	Forms part of the polypeptide exit tunnel
GAA2_RS18345	COG0051	transcription antitermination factor activity, RNA binding
GAA2_RS18360	COG0367	asparagine synthase
GAA2_RS18375	COG1953	Uracil, thiamine, allantoin
GAA2_RS18395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GAA2_RS18410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAA2_RS18415	COG2826	transposase and inactivated derivatives, IS30 family
GAA2_RS18435	COG0535	radical SAM domain protein
GAA2_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS18505	COG4948	Mandelate Racemase Muconate Lactonizing
GAA2_RS18515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GAA2_RS18520	COG1309	transcriptional regulator
GAA2_RS18525	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS18535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GAA2_RS18540	COG0049	tRNA binding
GAA2_RS18545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GAA2_RS18570	COG3284	Transcriptional regulator
GAA2_RS18580	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS18630	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS18670	COG2124	cytochrome p450
GAA2_RS18675	COG4221	oxidoreductase activity
GAA2_RS18690	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS18720	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS18735	COG1063	alcohol dehydrogenase
GAA2_RS18750	COG2186	Transcriptional regulator
GAA2_RS18755	COG1126	abc transporter atp-binding protein
GAA2_RS18760	COG0765	amino acid transport
GAA2_RS18780	COG1063	alcohol dehydrogenase
GAA2_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS18805	COG1309	transcriptional regulator
GAA2_RS18820	COG2226	methyltransferase
GAA2_RS18825	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS18930	COG0697	spore germination
GAA2_RS18950	COG3415	Transposase
GAA2_RS18950	COG2801	Transposase and inactivated derivatives
GAA2_RS18990	COG1316	TRANSCRIPTIONal
GAA2_RS19005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GAA2_RS19025	COG0456	acetyltransferase
GAA2_RS19025	COG0454	-acetyltransferase
GAA2_RS19030	COG0745	RESPONSE REGULATOR receiver
GAA2_RS19040	COG2897	thiosulfate sulfurtransferase activity
GAA2_RS19050	COG4044	May play a role in the intracellular transport of hydrophobic ligands
GAA2_RS19100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAA2_RS19120	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS19125	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS19130	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS19135	COG2070	2-Nitropropane dioxygenase
GAA2_RS19155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS19195	COG2124	cytochrome p450
GAA2_RS19200	COG0183	Belongs to the thiolase family
GAA2_RS19215	COG2124	cytochrome p450
GAA2_RS19230	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS19270	COG1024	Enoyl-CoA hydratase
GAA2_RS19295	COG2375	cellular response to nickel ion
GAA2_RS19295	COG1132	(ABC) transporter
GAA2_RS19300	COG1309	transcriptional regulator
GAA2_RS19305	COG1012	belongs to the aldehyde dehydrogenase family
GAA2_RS19310	COG0183	Belongs to the thiolase family
GAA2_RS19320	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS19325	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS19335	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS19360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GAA2_RS19380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GAA2_RS19385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GAA2_RS19425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GAA2_RS19430	COG0302	gtp cyclohydrolase
GAA2_RS19435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GAA2_RS19450	COG0037	tRNA processing
GAA2_RS19460	COG2027	D-alanyl-D-alanine carboxypeptidase
GAA2_RS19515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GAA2_RS19520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GAA2_RS19525	COG1120	ATPase activity
GAA2_RS19530	COG0038	chloride channel
GAA2_RS19585	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GAA2_RS19590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GAA2_RS19615	COG4129	membrane
GAA2_RS19660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GAA2_RS19670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GAA2_RS19675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GAA2_RS19680	COG0247	lactate metabolic process
GAA2_RS19680	COG0277	FAD linked oxidase domain protein
GAA2_RS19690	COG0006	proline dipeptidase activity
GAA2_RS19695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GAA2_RS19700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GAA2_RS19705	COG0477	Major facilitator Superfamily
GAA2_RS19745	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GAA2_RS19750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GAA2_RS19755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GAA2_RS19775	COG0519	Catalyzes the synthesis of GMP from XMP
GAA2_RS19790	COG3383	formate dehydrogenase (NAD+) activity
GAA2_RS19790	COG0243	molybdopterin cofactor binding
GAA2_RS19800	COG0437	4 iron, 4 sulfur cluster binding
GAA2_RS19810	COG0709	Synthesizes selenophosphate from selenide and ATP
GAA2_RS19830	COG0542	response to heat
GAA2_RS19855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GAA2_RS19870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAA2_RS19880	COG0745	RESPONSE REGULATOR receiver
GAA2_RS19885	COG2205	protein histidine kinase activity
GAA2_RS19890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GAA2_RS19950	COG0659	secondary active sulfate transmembrane transporter activity
GAA2_RS19960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GAA2_RS19965	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS19985	COG1397	ADP-ribosylglycohydrolase
GAA2_RS20030	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS20040	COG2188	Transcriptional regulator
GAA2_RS20065	COG1408	metallophosphoesterase
GAA2_RS20080	COG3485	protocatechuate 3,4-dioxygenase
GAA2_RS20085	COG4948	Mandelate Racemase Muconate Lactonizing
GAA2_RS20090	COG0583	DNA-binding transcription factor activity
GAA2_RS20095	COG4638	Rieske (2fe-2S)
GAA2_RS20125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GAA2_RS20130	COG0183	Belongs to the thiolase family
GAA2_RS20135	COG0583	DNA-binding transcription factor activity
GAA2_RS20180	COG2188	Transcriptional regulator
GAA2_RS20195	COG2030	dehydratase
GAA2_RS20200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAA2_RS20205	COG5285	phytanoyl-CoA dioxygenase
GAA2_RS20215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GAA2_RS20215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GAA2_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS20240	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS20285	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS20290	COG1609	Transcriptional regulator
GAA2_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS20310	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS20330	COG0183	Belongs to the thiolase family
GAA2_RS20345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GAA2_RS20350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GAA2_RS20355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAA2_RS20360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAA2_RS20360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAA2_RS20365	COG1113	amino acid transport
GAA2_RS20375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GAA2_RS20405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GAA2_RS20405	COG0574	Belongs to the PEP-utilizing enzyme family
GAA2_RS20440	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS20445	COG0583	DNA-binding transcription factor activity
GAA2_RS20450	COG2199	diguanylate cyclase activity
GAA2_RS20455	COG0277	FAD linked oxidase domain protein
GAA2_RS20500	COG0789	Transcriptional regulator
GAA2_RS20505	COG0484	heat shock protein binding
GAA2_RS20510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GAA2_RS20515	COG0443	Heat shock 70 kDa protein
GAA2_RS20610	COG1802	Transcriptional regulator
GAA2_RS20665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS20685	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS20695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GAA2_RS20705	COG3842	ATPase activity
GAA2_RS20715	COG1840	ABC-type Fe3 transport system, periplasmic component
GAA2_RS20730	COG2181	nitrate reductase activity
GAA2_RS20730	COG0247	lactate metabolic process
GAA2_RS20755	COG0477	Major facilitator Superfamily
GAA2_RS20770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GAA2_RS20790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GAA2_RS20825	COG0402	S-adenosylhomocysteine deaminase activity
GAA2_RS20840	COG0402	S-adenosylhomocysteine deaminase activity
GAA2_RS20870	COG0259	pyridoxamine-phosphate oxidase activity
GAA2_RS20875	COG0402	S-adenosylhomocysteine deaminase activity
GAA2_RS20880	COG2409	Drug exporters of the RND superfamily
GAA2_RS20915	COG0411	ABC transporter
GAA2_RS20940	COG0477	Major facilitator Superfamily
GAA2_RS20975	COG2197	response regulator
GAA2_RS20985	COG1131	(ABC) transporter
GAA2_RS20990	COG2022	thiamine diphosphate biosynthetic process
GAA2_RS21000	COG2022	thiamine diphosphate biosynthetic process
GAA2_RS21000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GAA2_RS21005	COG0352	thiamine-phosphate diphosphorylase activity
GAA2_RS21025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GAA2_RS21035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GAA2_RS21045	COG0277	FAD linked oxidase domain protein
GAA2_RS21055	COG2902	Dehydrogenase
GAA2_RS21075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS21075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS21080	COG3192	ethanolamine utilization protein
GAA2_RS21100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GAA2_RS21115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAA2_RS21120	COG1132	(ABC) transporter
GAA2_RS21130	COG2149	membrane
GAA2_RS21135	COG0657	acetylesterase activity
GAA2_RS21180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GAA2_RS21185	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS21205	COG0183	Belongs to the thiolase family
GAA2_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS21215	COG2030	dehydratase
GAA2_RS21230	COG1472	Belongs to the glycosyl hydrolase 3 family
GAA2_RS21240	COG4977	sequence-specific DNA binding
GAA2_RS21290	COG0438	transferase activity, transferring glycosyl groups
GAA2_RS21295	COG0500	methyltransferase
GAA2_RS21310	COG1136	(ABC) transporter
GAA2_RS21310	COG0577	efflux transmembrane transporter activity
GAA2_RS21320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GAA2_RS21355	COG2814	Major facilitator Superfamily
GAA2_RS21360	COG2197	response regulator
GAA2_RS21405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GAA2_RS21410	COG3590	peptidase
GAA2_RS21425	COG2409	Drug exporters of the RND superfamily
GAA2_RS21430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GAA2_RS21435	COG1124	(ABC) transporter
GAA2_RS21440	COG0444	Belongs to the ABC transporter superfamily
GAA2_RS21445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GAA2_RS21480	COG1250	3-hydroxyacyl-CoA dehydrogenase
GAA2_RS21480	COG1024	Enoyl-CoA hydratase
GAA2_RS21485	COG0183	Belongs to the thiolase family
GAA2_RS21490	COG1309	transcriptional regulator
GAA2_RS21495	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GAA2_RS21615	COG0142	geranyltranstransferase activity
GAA2_RS21630	COG0463	Glycosyl transferase, family 2
GAA2_RS21635	COG1233	COG1233 Phytoene dehydrogenase and related
GAA2_RS21650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GAA2_RS21665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GAA2_RS21695	COG1793	dna ligase
GAA2_RS21695	COG3285	dna ligase
GAA2_RS21700	COG0477	Major facilitator Superfamily
GAA2_RS21730	COG1484	DNA-dependent DNA replication
GAA2_RS21735	COG4584	PFAM Integrase catalytic
GAA2_RS21755	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GAA2_RS21765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GAA2_RS21770	COG1053	succinate dehydrogenase
GAA2_RS21785	COG2608	mercury ion transmembrane transporter activity
GAA2_RS21790	COG1937	Protein conserved in bacteria
GAA2_RS21800	COG0596	Alpha beta hydrolase
GAA2_RS21810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GAA2_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS21835	COG1982	Orn Lys Arg decarboxylase major
GAA2_RS21865	COG1064	alcohol dehydrogenase
GAA2_RS21895	COG2837	iron assimilation
GAA2_RS21930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GAA2_RS21935	COG0328	RNA-DNA hybrid ribonuclease activity
GAA2_RS21940	COG4106	trans-aconitate 2-methyltransferase activity
GAA2_RS21975	COG0583	DNA-binding transcription factor activity
GAA2_RS22010	COG0693	protein deglycase activity
GAA2_RS22040	COG4221	oxidoreductase activity
GAA2_RS22095	COG4608	Belongs to the ABC transporter superfamily
GAA2_RS22100	COG0444	Belongs to the ABC transporter superfamily
GAA2_RS22105	COG0747	negative chemotaxis
GAA2_RS22110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GAA2_RS22115	COG0601	transmembrane transport
GAA2_RS22120	COG2188	Transcriptional regulator
GAA2_RS22135	COG1028	Short-chain dehydrogenase reductase Sdr
GAA2_RS22140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS22140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAA2_RS22145	COG2354	Protein conserved in bacteria
GAA2_RS22155	COG3842	ATPase activity
GAA2_RS22160	COG0395	ABC-type sugar transport system, permease component
GAA2_RS22165	COG1175	transmembrane transport
GAA2_RS22170	COG2182	Extracellular solute-binding protein
GAA2_RS22180	COG1063	alcohol dehydrogenase
GAA2_RS22190	COG1070	Carbohydrate kinase
GAA2_RS22195	COG4106	trans-aconitate 2-methyltransferase activity
GAA2_RS22210	COG1278	Cold shock
GAA2_RS22270	COG2223	nitrite transmembrane transporter activity
GAA2_RS22290	COG0305	Participates in initiation and elongation during chromosome replication
GAA2_RS22300	COG0359	binds to the 23S rRNA
GAA2_RS22305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GAA2_RS22310	COG0629	single-stranded DNA binding
GAA2_RS22345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GAA2_RS22360	COG1260	myo-inositol-1-phosphate synthase
GAA2_RS22370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GAA2_RS22415	COG1358	cellular component organization or biogenesis
GAA2_RS22445	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS22465	COG1309	transcriptional regulator
GAA2_RS22480	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GAA2_RS22485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GAA2_RS22490	COG1547	Domain of unknown function (DUF309)
GAA2_RS22495	COG0318	PFAM AMP-dependent synthetase and ligase
GAA2_RS22500	COG0129	dihydroxy-acid dehydratase activity
GAA2_RS22505	COG1764	response to oxidative stress
GAA2_RS22510	COG1846	Transcriptional regulator
GAA2_RS22530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GAA2_RS22535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GAA2_RS22560	COG2814	Major facilitator Superfamily
GAA2_RS22580	COG0069	glutamate synthase activity
GAA2_RS22585	COG2218	PFAM glutamate synthase alpha subunit domain protein
GAA2_RS22590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GAA2_RS22600	COG0004	ammonium transporteR
GAA2_RS22640	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GAA2_RS22645	COG4221	oxidoreductase activity
GAA2_RS22650	COG3631	Ketosteroid isomerase-related protein
GAA2_RS22665	COG0714	Associated with various cellular activities
GAA2_RS22705	COG1960	acyl-CoA dehydrogenase activity
GAA2_RS22715	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GAA2_RS22720	COG0495	leucyl-tRNA aminoacylation
GAA2_RS22735	COG4584	PFAM Integrase catalytic
GAA2_RS22740	COG1484	DNA-dependent DNA replication
GAA2_RS22755	COG1678	Uncharacterized ACR, COG1678
GAA2_RS22770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GAA2_RS22800	COG0617	tRNA 3'-terminal CCA addition
GAA2_RS22820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GAA2_RS22825	COG0569	domain protein
GAA2_RS22845	COG1484	DNA-dependent DNA replication
GAA2_RS22850	COG4584	PFAM Integrase catalytic
GAA2_RS22885	COG1595	DNA-templated transcription, initiation
GAA2_RS22905	COG0860	N-Acetylmuramoyl-L-alanine amidase
GAA2_RS22905	COG3409	Peptidoglycan-binding domain 1 protein
GAA2_RS22920	COG1192	Involved in chromosome partitioning
GAA2_RS22925	COG0357	Ribosomal RNA small subunit methyltransferase G
GAA2_RS22945	COG0594	ribonuclease P activity