locus-tag	class	description
D7316_RS00255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D7316_RS00260	COG0066	3-isopropylmalate dehydratase activity
D7316_RS00270	COG0494	nUDIX hydrolase
D7316_RS00270	COG0406	alpha-ribazole phosphatase activity
D7316_RS00275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D7316_RS00280	COG1920	GTP binding
D7316_RS00285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7316_RS00300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D7316_RS00315	COG1024	Enoyl-CoA hydratase
D7316_RS00320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7316_RS00325	COG1461	Dihydroxyacetone kinase
D7316_RS00330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7316_RS00345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D7316_RS00350	COG0542	response to heat
D7316_RS00360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7316_RS00365	COG0799	negative regulation of ribosome biogenesis
D7316_RS00370	COG0406	alpha-ribazole phosphatase activity
D7316_RS00375	COG2755	lipolytic protein G-D-S-L family
D7316_RS00400	COG0268	Binds directly to 16S ribosomal RNA
D7316_RS00420	COG1305	Transglutaminase-like
D7316_RS00435	COG0481	GTPase activity
D7316_RS00440	COG0339	signal peptide processing
D7316_RS00445	COG3387	PFAM Glycoside hydrolase 15-related
D7316_RS00455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D7316_RS00460	COG4208	sulfate ABC transporter
D7316_RS00465	COG4208	sulfate ABC transporter
D7316_RS00470	COG3842	ATPase activity
D7316_RS00510	COG1420	regulation of RNA biosynthetic process
D7316_RS00515	COG0484	heat shock protein binding
D7316_RS00540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7316_RS00565	COG1381	Involved in DNA repair and RecF pathway recombination
D7316_RS00570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7316_RS00595	COG2234	aminopeptidase activity
D7316_RS00600	COG0423	glycine-tRNA ligase activity
D7316_RS00605	COG1278	Cold shock
D7316_RS00615	COG0358	DNA primase activity
D7316_RS00630	COG1802	Transcriptional regulator
D7316_RS00640	COG1335	isochorismatase
D7316_RS00665	COG1802	Transcriptional regulator
D7316_RS00670	COG1960	acyl-CoA dehydrogenase activity
D7316_RS00680	COG1309	transcriptional regulator
D7316_RS00690	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS00720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7316_RS00735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D7316_RS00810	COG2890	protein-(glutamine-N5) methyltransferase activity
D7316_RS00820	COG0656	L-ascorbic acid biosynthetic process
D7316_RS00830	COG2723	6-phospho-beta-galactosidase activity
D7316_RS00850	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D7316_RS00900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D7316_RS00915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D7316_RS00920	COG2267	carboxylic ester hydrolase activity
D7316_RS00925	COG0174	glutamine synthetase
D7316_RS00930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D7316_RS00955	COG0477	Major facilitator Superfamily
D7316_RS00960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D7316_RS00980	COG0174	glutamine synthetase
D7316_RS00990	COG0833	amino acid
D7316_RS01000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7316_RS01005	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS01015	COG2186	Transcriptional regulator
D7316_RS01025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D7316_RS01040	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7316_RS01045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D7316_RS01050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7316_RS01055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7316_RS01060	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D7316_RS01065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D7316_RS01090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7316_RS01100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D7316_RS01115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D7316_RS01130	COG1845	cytochrome c oxidase, subunit III
D7316_RS01140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D7316_RS01160	COG0791	NLP P60 protein
D7316_RS01175	COG0438	transferase activity, transferring glycosyl groups
D7316_RS01205	COG1940	carbohydrate kinase activity
D7316_RS01225	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D7316_RS01255	COG0142	geranyltranstransferase activity
D7316_RS01305	COG0768	penicillin binding
D7316_RS01320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7316_RS01325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D7316_RS01335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7316_RS01340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7316_RS01350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7316_RS01355	COG1496	oxidoreductase activity
D7316_RS01365	COG1799	cell septum assembly
D7316_RS01385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D7316_RS01390	COG1252	NADH dehydrogenase
D7316_RS01395	COG1595	DNA-templated transcription, initiation
D7316_RS01425	COG0252	asparaginase activity
D7316_RS01440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7316_RS01475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS01480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS01530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D7316_RS01530	COG2755	lipolytic protein G-D-S-L family
D7316_RS01540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7316_RS01545	COG0156	8-amino-7-oxononanoate synthase activity
D7316_RS01550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D7316_RS01555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D7316_RS01575	COG0024	Methionine aminopeptidase
D7316_RS01590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D7316_RS01600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D7316_RS01605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7316_RS01615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D7316_RS01630	COG0483	inositol monophosphate 1-phosphatase activity
D7316_RS01635	COG0107	imidazoleglycerol-phosphate synthase activity
D7316_RS01640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D7316_RS01650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7316_RS01660	COG0134	indole-3-glycerol-phosphate synthase activity
D7316_RS01670	COG0159	tryptophan synthase activity
D7316_RS01675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D7316_RS01680	COG0070	glutamate synthase
D7316_RS01680	COG0069	glutamate synthase activity
D7316_RS01680	COG0067	glutamate synthase
D7316_RS01695	COG1946	Acyl-CoA thioesterase
D7316_RS01770	COG3012	SEC-C Motif Domain Protein
D7316_RS01780	COG2020	methyltransferase activity
D7316_RS01785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D7316_RS01795	COG0321	lipoyl(octanoyl) transferase activity
D7316_RS01795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D7316_RS01805	COG0471	metal ion transport
D7316_RS01820	COG1053	succinate dehydrogenase
D7316_RS01830	COG0833	amino acid
D7316_RS01835	COG3321	synthase
D7316_RS01835	COG0604	alcohol dehydrogenase
D7316_RS01840	COG0596	Alpha beta hydrolase
D7316_RS01850	COG0596	Alpha beta hydrolase
D7316_RS01890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7316_RS01955	COG0765	amino acid transport
D7316_RS01960	COG1126	abc transporter atp-binding protein
D7316_RS01965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D7316_RS01970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D7316_RS01990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D7316_RS01990	COG0237	dephospho-CoA kinase activity
D7316_RS02050	COG3973	AAA domain
D7316_RS02065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7316_RS02105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7316_RS02110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7316_RS02120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7316_RS02125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7316_RS02125	COG0072	phenylalanine-tRNA ligase activity
D7316_RS02135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D7316_RS02140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D7316_RS02145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7316_RS02150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7316_RS02155	COG1438	arginine binding
D7316_RS02160	COG0137	argininosuccinate synthase activity
D7316_RS02165	COG0165	Argininosuccinate lyase
D7316_RS02180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7316_RS02215	COG2072	flavoprotein involved in K transport
D7316_RS02225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D7316_RS02225	COG2066	Belongs to the glutaminase family
D7316_RS02230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D7316_RS02250	COG0183	Belongs to the thiolase family
D7316_RS02255	COG2409	Drug exporters of the RND superfamily
D7316_RS02280	COG0366	Alpha amylase catalytic
D7316_RS02290	COG1335	isochorismatase
D7316_RS02295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D7316_RS02335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D7316_RS02345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D7316_RS02350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7316_RS02355	COG0438	transferase activity, transferring glycosyl groups
D7316_RS02375	COG1435	thymidine kinase activity
D7316_RS02390	COG0673	inositol 2-dehydrogenase activity
D7316_RS02395	COG1082	Xylose isomerase domain protein TIM barrel
D7316_RS02405	COG0673	inositol 2-dehydrogenase activity
D7316_RS02410	COG1609	Transcriptional regulator
D7316_RS02420	COG1764	response to oxidative stress
D7316_RS02425	COG1846	Transcriptional regulator
D7316_RS02435	COG2890	protein-(glutamine-N5) methyltransferase activity
D7316_RS02450	COG1022	Amp-dependent synthetase and ligase
D7316_RS02505	COG1376	ErfK ybiS ycfS ynhG family protein
D7316_RS02515	COG1376	ErfK ybiS ycfS ynhG family protein
D7316_RS02520	COG1960	acyl-CoA dehydrogenase activity
D7316_RS02555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D7316_RS02560	COG0433	COG0433 Predicted ATPase
D7316_RS02565	COG4221	oxidoreductase activity
D7316_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7316_RS02570	COG1902	pentaerythritol trinitrate reductase activity
D7316_RS02580	COG1132	(ABC) transporter
D7316_RS02585	COG2233	PERMEase
D7316_RS02600	COG3336	cytochrome c oxidase
D7316_RS02615	COG2902	Dehydrogenase
D7316_RS02625	COG0824	Thioesterase
D7316_RS02635	COG0366	Alpha amylase catalytic
D7316_RS02655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D7316_RS02660	COG1301	dicarboxylic acid transport
D7316_RS02665	COG3290	protein histidine kinase activity
D7316_RS02670	COG4565	transcriptional regulatory protein
D7316_RS02680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D7316_RS02685	COG0501	Belongs to the peptidase M48B family
D7316_RS02690	COG0698	ribose 5-phosphate isomerase
D7316_RS02710	COG1376	ErfK ybiS ycfS ynhG family protein
D7316_RS02735	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7316_RS02740	COG0740	serine-type endopeptidase activity
D7316_RS02745	COG0740	serine-type endopeptidase activity
D7316_RS02765	COG0525	valine-tRNA ligase activity
D7316_RS02770	COG0285	dihydrofolate synthase activity
D7316_RS02785	COG0105	UTP biosynthetic process
D7316_RS02790	COG1530	ribonuclease E activity
D7316_RS02805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7316_RS02810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D7316_RS02820	COG1917	Cupin 2, conserved barrel domain protein
D7316_RS02825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7316_RS02830	COG0456	acetyltransferase
D7316_RS02835	COG0742	ribosomal rna small subunit methyltransferase
D7316_RS02840	COG2070	2-Nitropropane dioxygenase
D7316_RS02860	COG0571	ribonuclease III activity
D7316_RS02875	COG1254	Belongs to the acylphosphatase family
D7316_RS02890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS02895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS02910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D7316_RS02925	COG0228	four-way junction DNA binding
D7316_RS02940	COG0336	Belongs to the RNA methyltransferase TrmD family
D7316_RS02980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D7316_RS03030	COG4974	Belongs to the 'phage' integrase family
D7316_RS03040	COG0052	Belongs to the universal ribosomal protein uS2 family
D7316_RS03045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7316_RS03065	COG0463	Glycosyl transferase, family 2
D7316_RS03070	COG0528	UMP kinase activity
D7316_RS03090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D7316_RS03110	COG0750	zinc metalloprotease
D7316_RS03125	COG0768	penicillin binding
D7316_RS03130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D7316_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS03140	COG4558	Periplasmic binding protein
D7316_RS03150	COG1492	cobalamin metabolic process
D7316_RS03155	COG0596	Alpha beta hydrolase
D7316_RS03165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7316_RS03180	COG0579	oxidoreductase
D7316_RS03230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D7316_RS03230	COG1648	precorrin-2 dehydrogenase activity
D7316_RS03245	COG3022	response to hydroperoxide
D7316_RS03250	COG0442	prolyl-tRNA aminoacylation
D7316_RS03265	COG0779	Required for maturation of 30S ribosomal subunits
D7316_RS03285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7316_RS03290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7316_RS03305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7316_RS03310	COG2977	Belongs to the P-Pant transferase superfamily
D7316_RS03315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7316_RS03330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D7316_RS03350	COG0686	Belongs to the AlaDH PNT family
D7316_RS03360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D7316_RS03425	COG3214	Protein conserved in bacteria
D7316_RS03430	COG2130	NADP-dependent
D7316_RS03450	COG2365	Tyrosine phosphatase family
D7316_RS03470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7316_RS03475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D7316_RS03485	COG1674	ftsk spoiiie
D7316_RS03505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D7316_RS03515	COG1396	sequence-specific DNA binding
D7316_RS03520	COG1842	Phage shock protein A
D7316_RS03525	COG1819	glycosyl
D7316_RS03535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7316_RS03540	COG2137	regulation of response to DNA damage stimulus
D7316_RS03545	COG0765	amino acid transport
D7316_RS03550	COG0765	amino acid transport
D7316_RS03555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7316_RS03560	COG1126	abc transporter atp-binding protein
D7316_RS03565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7316_RS03575	COG0583	DNA-binding transcription factor activity
D7316_RS03590	COG1196	nuclear chromosome segregation
D7316_RS03600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D7316_RS03605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D7316_RS03610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7316_RS03620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7316_RS03620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7316_RS03620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7316_RS03670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7316_RS03710	COG0123	including yeast histone deacetylase and acetoin utilization protein
D7316_RS03715	COG1042	CoA-binding domain protein
D7316_RS03715	COG0045	succinate-CoA ligase (ADP-forming) activity
D7316_RS03715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7316_RS03750	COG0730	response to heat
D7316_RS03770	COG0483	inositol monophosphate 1-phosphatase activity
D7316_RS03790	COG0756	dUTP diphosphatase activity
D7316_RS03820	COG0569	domain protein
D7316_RS03825	COG0531	amino acid
D7316_RS03830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7316_RS03835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D7316_RS03840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D7316_RS03850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D7316_RS03855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D7316_RS03865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7316_RS03885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7316_RS03965	COG1819	glycosyl
D7316_RS03975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7316_RS03980	COG1051	belongs to the nudix hydrolase family
D7316_RS03990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D7316_RS04005	COG1560	Kdo2-lipid A biosynthetic process
D7316_RS04010	COG0438	transferase activity, transferring glycosyl groups
D7316_RS04020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D7316_RS04025	COG0631	protein serine/threonine phosphatase activity
D7316_RS04035	COG1946	Acyl-CoA thioesterase
D7316_RS04040	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D7316_RS04055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D7316_RS04060	COG0632	four-way junction helicase activity
D7316_RS04080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7316_RS04085	COG0747	negative chemotaxis
D7316_RS04095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7316_RS04110	COG0124	histidyl-tRNA synthetase
D7316_RS04125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7316_RS04155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7316_RS04170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7316_RS04180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7316_RS04190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D7316_RS04200	COG0006	proline dipeptidase activity
D7316_RS04205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D7316_RS04210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7316_RS04215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D7316_RS04220	COG0540	Belongs to the ATCase OTCase family
D7316_RS04235	COG0505	Belongs to the CarA family
D7316_RS04245	COG0284	orotidine-5'-phosphate decarboxylase activity
D7316_RS04270	COG0194	GDP metabolic process
D7316_RS04275	COG1758	RNA polymerase activity
D7316_RS04285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D7316_RS04295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D7316_RS04320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7316_RS04320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7316_RS04325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7316_RS04355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D7316_RS04360	COG0126	phosphoglycerate kinase activity
D7316_RS04365	COG0149	triose-phosphate isomerase activity
D7316_RS04375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D7316_RS04380	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7316_RS04400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D7316_RS04410	COG0109	protoheme IX farnesyltransferase activity
D7316_RS04425	COG1612	heme a metabolic process
D7316_RS04460	COG0396	ATPase activity
D7316_RS04465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7316_RS04470	COG0822	iron-sulfur transferase activity
D7316_RS04475	COG2151	metal-sulfur cluster biosynthetic enzyme
D7316_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS04510	COG0488	(ABC) transporter
D7316_RS04525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7316_RS04530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7316_RS04540	COG0028	Belongs to the TPP enzyme family
D7316_RS04545	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS04560	COG1309	transcriptional regulator
D7316_RS04565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D7316_RS04575	COG3883	PFAM NLP P60 protein
D7316_RS04575	COG0791	NLP P60 protein
D7316_RS04580	COG0714	Associated with various cellular activities
D7316_RS04600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7316_RS04605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D7316_RS04675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7316_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS04685	COG3433	isochorismatase activity
D7316_RS04685	COG1535	isochorismatase
D7316_RS04690	COG1021	2,3-dihydroxybenzoate-AMP ligase
D7316_RS04705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS04710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS04715	COG3433	isochorismatase activity
D7316_RS04715	COG1535	isochorismatase
D7316_RS04725	COG0475	glutathione-regulated potassium exporter activity
D7316_RS04730	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D7316_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS04755	COG0668	transmembrane transport
D7316_RS04760	COG0183	Belongs to the thiolase family
D7316_RS04775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7316_RS04785	COG2132	Multicopper oxidase
D7316_RS04805	COG1968	undecaprenyl-diphosphatase activity
D7316_RS04825	COG0215	cysteine-tRNA ligase activity
D7316_RS04840	COG0646	methionine synthase
D7316_RS04840	COG1410	methionine synthase
D7316_RS04880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D7316_RS04900	COG1222	aaa ATPase
D7316_RS04905	COG0058	SHG alpha-glucan phosphorylase activity
D7316_RS04920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7316_RS04925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7316_RS04930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7316_RS04940	COG2378	regulation of single-species biofilm formation
D7316_RS04945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7316_RS04985	COG0300	oxidoreductase activity
D7316_RS05105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS05130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS05135	COG0546	phosphoglycolate phosphatase activity
D7316_RS05145	COG0753	catalase activity
D7316_RS05170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7316_RS05180	COG0583	DNA-binding transcription factor activity
D7316_RS05195	COG1960	acyl-CoA dehydrogenase activity
D7316_RS05220	COG2207	Transcriptional regulator
D7316_RS05230	COG4585	Histidine kinase
D7316_RS05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7316_RS05275	COG0569	domain protein
D7316_RS05275	COG2985	domain, Protein
D7316_RS05285	COG1120	ATPase activity
D7316_RS05290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS05295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS05300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7316_RS05305	COG0477	Major facilitator Superfamily
D7316_RS05325	COG1902	pentaerythritol trinitrate reductase activity
D7316_RS05330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS05330	COG0723	plastoquinol--plastocyanin reductase activity
D7316_RS05335	COG3046	protein related to deoxyribodipyrimidine photolyase
D7316_RS05380	COG4941	Belongs to the sigma-70 factor family
D7316_RS05405	COG0351	phosphomethylpyrimidine kinase
D7316_RS05430	COG0439	Biotin carboxylase
D7316_RS05445	COG0778	Nitroreductase
D7316_RS05470	COG3835	regulator
D7316_RS05475	COG0657	acetylesterase activity
D7316_RS05500	COG3795	YCII-related domain
D7316_RS05505	COG4941	Belongs to the sigma-70 factor family
D7316_RS05545	COG0443	Heat shock 70 kDa protein
D7316_RS05575	COG2755	lipolytic protein G-D-S-L family
D7316_RS05585	COG2186	Transcriptional regulator
D7316_RS05590	COG0402	S-adenosylhomocysteine deaminase activity
D7316_RS05605	COG0154	amidase activity
D7316_RS05615	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
D7316_RS05625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D7316_RS05635	COG1672	PFAM Archaeal ATPase
D7316_RS05635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D7316_RS05640	COG2197	response regulator
D7316_RS05650	COG0477	Major facilitator Superfamily
D7316_RS05710	COG0596	Alpha beta hydrolase
D7316_RS05770	COG0346	lactoylglutathione lyase activity
D7316_RS05775	COG0640	Transcriptional regulator
D7316_RS05790	COG3467	pyridoxamine 5'-phosphate
D7316_RS05800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D7316_RS05810	COG0545	Peptidyl-prolyl cis-trans isomerase
D7316_RS05825	COG1280	lysine exporter protein (LysE YggA)
D7316_RS05830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7316_RS05835	COG3360	Dodecin
D7316_RS05845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D7316_RS05880	COG1309	transcriptional regulator
D7316_RS05885	COG1129	ABC transporter
D7316_RS05885	COG0842	Transport permease protein
D7316_RS05890	COG1129	ABC transporter
D7316_RS05890	COG0842	Transport permease protein
D7316_RS05895	COG0842	Transport permease protein
D7316_RS05910	COG1070	Carbohydrate kinase
D7316_RS05915	COG0246	Mannitol dehydrogenase
D7316_RS05920	COG1063	alcohol dehydrogenase
D7316_RS05930	COG2182	Extracellular solute-binding protein
D7316_RS05935	COG1175	transmembrane transport
D7316_RS05940	COG0395	ABC-type sugar transport system, permease component
D7316_RS05945	COG3842	ATPase activity
D7316_RS05970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7316_RS05995	COG2971	BadF BadG BcrA BcrD
D7316_RS06000	COG0326	Molecular chaperone. Has ATPase activity
D7316_RS06005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7316_RS06015	COG1074	ATP-dependent DNA helicase activity
D7316_RS06035	COG1252	NADH dehydrogenase
D7316_RS06045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7316_RS06055	COG0804	urea catabolic process
D7316_RS06065	COG0831	urea catabolic process
D7316_RS06090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D7316_RS06100	COG1253	flavin adenine dinucleotide binding
D7316_RS06105	COG1253	flavin adenine dinucleotide binding
D7316_RS06115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D7316_RS06125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7316_RS06125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7316_RS06160	COG0653	protein targeting
D7316_RS06180	COG0039	L-malate dehydrogenase activity
D7316_RS06185	COG2326	polyphosphate kinase activity
D7316_RS06200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7316_RS06205	COG1522	sequence-specific DNA binding
D7316_RS06215	COG0765	amino acid transport
D7316_RS06220	COG1126	abc transporter atp-binding protein
D7316_RS06240	COG0235	Class ii aldolase
D7316_RS06275	COG0028	Belongs to the TPP enzyme family
D7316_RS06285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7316_RS06330	COG0531	amino acid
D7316_RS06375	COG1160	GTP binding
D7316_RS06390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D7316_RS06410	COG0494	nUDIX hydrolase
D7316_RS06435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D7316_RS06450	COG0647	UMP catabolic process
D7316_RS06470	COG2226	methyltransferase
D7316_RS06475	COG2197	response regulator
D7316_RS06480	COG4585	Histidine kinase
D7316_RS06485	COG1454	alcohol dehydrogenase
D7316_RS06505	COG1122	ATPase activity
D7316_RS06520	COG0310	cobalt ion transport
D7316_RS06525	COG0640	Transcriptional regulator
D7316_RS06545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D7316_RS06550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D7316_RS06560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D7316_RS06580	COG0356	it plays a direct role in the translocation of protons across the membrane
D7316_RS06595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7316_RS06605	COG2890	protein-(glutamine-N5) methyltransferase activity
D7316_RS06610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7316_RS06615	COG0254	rRNA binding
D7316_RS06620	COG0067	glutamate synthase
D7316_RS06620	COG0069	glutamate synthase activity
D7316_RS06620	COG0070	glutamate synthase
D7316_RS06625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D7316_RS06640	COG0083	homoserine kinase activity
D7316_RS06645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D7316_RS06650	COG0460	homoserine dehydrogenase
D7316_RS06655	COG0019	diaminopimelate decarboxylase activity
D7316_RS06660	COG0018	arginyl-trna synthetase
D7316_RS06690	COG0419	ATPase involved in DNA repair
D7316_RS06695	COG0420	3'-5' exonuclease activity
D7316_RS06710	COG0435	Glutathione S-transferase
D7316_RS06720	COG1132	(ABC) transporter
D7316_RS06725	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7316_RS06725	COG0567	Dehydrogenase, E1 component
D7316_RS06730	COG1309	transcriptional regulator
D7316_RS06735	COG2072	flavoprotein involved in K transport
D7316_RS06750	COG2095	MarC family integral membrane protein
D7316_RS06805	COG2239	Acts as a magnesium transporter
D7316_RS06830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7316_RS06835	COG5662	AntiSigma factor
D7316_RS06845	COG4122	O-methyltransferase activity
D7316_RS06865	COG1316	TRANSCRIPTIONal
D7316_RS06890	COG4106	trans-aconitate 2-methyltransferase activity
D7316_RS06970	COG2205	protein histidine kinase activity
D7316_RS06985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS06995	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D7316_RS06995	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D7316_RS07000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7316_RS07010	COG0424	maF-like protein
D7316_RS07020	COG5479	isomerase activity
D7316_RS07020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7316_RS07055	COG4770	biotin carboxylase activity
D7316_RS07070	COG2233	PERMEase
D7316_RS07110	COG0572	uridine kinase
D7316_RS07125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D7316_RS07135	COG1396	sequence-specific DNA binding
D7316_RS07135	COG3800	Transcriptional regulator
D7316_RS07140	COG0477	Major facilitator Superfamily
D7316_RS07155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7316_RS07160	COG1960	acyl-CoA dehydrogenase activity
D7316_RS07180	COG1201	RNA secondary structure unwinding
D7316_RS07200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7316_RS07215	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D7316_RS07215	COG1473	amidohydrolase
D7316_RS07220	COG1024	Enoyl-CoA hydratase
D7316_RS07230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7316_RS07235	COG1119	ATPase activity
D7316_RS07250	COG0791	NLP P60 protein
D7316_RS07275	COG2009	succinate dehydrogenase
D7316_RS07290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D7316_RS07310	COG0505	Belongs to the CarA family
D7316_RS07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS07330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7316_RS07335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7316_RS07340	COG1686	Belongs to the peptidase S11 family
D7316_RS07345	COG1295	ribonuclease BN
D7316_RS07350	COG0180	Tryptophanyl-tRNA synthetase
D7316_RS07370	COG2814	Major facilitator Superfamily
D7316_RS07375	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D7316_RS07380	COG2873	o-acetylhomoserine
D7316_RS07400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7316_RS07415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D7316_RS07420	COG1872	DUF167
D7316_RS07425	COG0587	DNA-directed DNA polymerase activity
D7316_RS07435	COG1335	isochorismatase
D7316_RS07475	COG0515	serine threonine protein kinase
D7316_RS07475	COG2815	serine threonine protein kinase
D7316_RS07480	COG2197	response regulator
D7316_RS07500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D7316_RS07500	COG0519	Catalyzes the synthesis of GMP from XMP
D7316_RS07505	COG1268	BioY protein
D7316_RS07510	COG1122	ATPase activity
D7316_RS07515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7316_RS07520	COG0516	GMP reductase activity
D7316_RS07555	COG0459	protein refolding
D7316_RS07560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7316_RS07565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7316_RS07570	COG0456	acetyltransferase
D7316_RS07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D7316_RS07600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7316_RS07635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7316_RS07640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D7316_RS07645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7316_RS07655	COG1674	ftsk spoiiie
D7316_RS07665	COG1404	Belongs to the peptidase S8 family
D7316_RS07680	COG1570	exodeoxyribonuclease VII activity
D7316_RS07685	COG1722	exodeoxyribonuclease VII activity
D7316_RS07695	COG0765	amino acid transport
D7316_RS07700	COG1126	abc transporter atp-binding protein
D7316_RS07705	COG1494	fructose-1,6-bisphosphatase
D7316_RS07735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D7316_RS07745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7316_RS07755	COG1072	(Pantothenic acid kinase))
D7316_RS07760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7316_RS07770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7316_RS07785	COG3540	Alkaline phosphatase
D7316_RS07790	COG0740	serine-type endopeptidase activity
D7316_RS07795	COG0740	serine-type endopeptidase activity
D7316_RS07800	COG1396	sequence-specific DNA binding
D7316_RS07830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7316_RS07835	COG1522	sequence-specific DNA binding
D7316_RS07840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7316_RS07845	COG0406	alpha-ribazole phosphatase activity
D7316_RS07850	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D7316_RS07875	COG1331	Highly conserved protein containing a thioredoxin domain
D7316_RS07885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7316_RS07935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7316_RS07950	COG2755	lipolytic protein G-D-S-L family
D7316_RS07955	COG0183	Belongs to the thiolase family
D7316_RS07960	COG2814	Major facilitator Superfamily
D7316_RS07975	COG2409	Drug exporters of the RND superfamily
D7316_RS08000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS08005	COG1120	ATPase activity
D7316_RS08010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS08015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS08025	COG1132	(ABC) transporter
D7316_RS08030	COG2375	cellular response to nickel ion
D7316_RS08030	COG1132	(ABC) transporter
D7316_RS08045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D7316_RS08125	COG0657	acetylesterase activity
D7316_RS08130	COG2814	Major facilitator Superfamily
D7316_RS08150	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D7316_RS08160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7316_RS08160	COG5479	isomerase activity
D7316_RS08165	COG2267	carboxylic ester hydrolase activity
D7316_RS08175	COG1741	Belongs to the pirin family
D7316_RS08235	COG1309	transcriptional regulator
D7316_RS08280	COG0148	phosphopyruvate hydratase activity
D7316_RS08290	COG0672	)-iron permease
D7316_RS08300	COG2837	iron assimilation
D7316_RS08305	COG3956	TIGRFAM MazG family protein
D7316_RS08320	COG3384	dioxygenase
D7316_RS08335	COG1174	glycine betaine transport
D7316_RS08345	COG1174	glycine betaine transport
D7316_RS08410	COG2072	flavoprotein involved in K transport
D7316_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS08420	COG0028	Belongs to the TPP enzyme family
D7316_RS08430	COG2175	clavaminate synthase activity
D7316_RS08435	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS08445	COG1024	Enoyl-CoA hydratase
D7316_RS08450	COG0427	acetyl-CoA hydrolase
D7316_RS08465	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS08470	COG0604	alcohol dehydrogenase
D7316_RS08485	COG1960	acyl-CoA dehydrogenase activity
D7316_RS08490	COG1960	acyl-CoA dehydrogenase activity
D7316_RS08495	COG1024	Enoyl-CoA hydratase
D7316_RS08505	COG1960	acyl-CoA dehydrogenase activity
D7316_RS08510	COG1802	Transcriptional regulator
D7316_RS08520	COG1393	Belongs to the ArsC family
D7316_RS08525	COG0367	asparagine synthase
D7316_RS08530	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
D7316_RS08535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D7316_RS08545	COG0471	metal ion transport
D7316_RS08545	COG0490	domain, Protein
D7316_RS08575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D7316_RS08590	COG0488	(ABC) transporter
D7316_RS08605	COG0488	(ABC) transporter
D7316_RS08620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7316_RS08635	COG3583	domain protein
D7316_RS08640	COG0084	hydrolase, TatD family'
D7316_RS08645	COG0384	phenazine biosynthesis protein PhzF
D7316_RS08690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D7316_RS08730	COG0254	rRNA binding
D7316_RS08740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7316_RS08745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7316_RS08750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7316_RS08755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7316_RS08805	COG0513	Belongs to the DEAD box helicase family
D7316_RS08815	COG5001	Diguanylate cyclase
D7316_RS08815	COG3300	MHYT domain
D7316_RS08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7316_RS08850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7316_RS08855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7316_RS08865	COG1115	amino acid carrier protein
D7316_RS08870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D7316_RS08900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7316_RS08920	COG0243	molybdopterin cofactor binding
D7316_RS08935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7316_RS08980	COG1216	Glycosyl transferase, family 2
D7316_RS09015	COG2860	membrane
D7316_RS09050	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D7316_RS09070	COG2175	clavaminate synthase activity
D7316_RS09075	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7316_RS09080	COG4521	taurine ABC transporter
D7316_RS09085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7316_RS09115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7316_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09135	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7316_RS09160	COG0494	nUDIX hydrolase
D7316_RS09190	COG0045	succinate-CoA ligase (ADP-forming) activity
D7316_RS09220	COG0166	Belongs to the GPI family
D7316_RS09240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7316_RS09245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7316_RS09255	COG0028	Belongs to the TPP enzyme family
D7316_RS09260	COG2205	protein histidine kinase activity
D7316_RS09265	COG0745	RESPONSE REGULATOR receiver
D7316_RS09270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7316_RS09275	COG1218	3'(2'),5'-bisphosphate nucleotidase
D7316_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS09325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7316_RS09345	COG0405	Gamma-glutamyltransferase
D7316_RS09355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D7316_RS09365	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS09370	COG0506	proline dehydrogenase activity
D7316_RS09390	COG3485	protocatechuate 3,4-dioxygenase
D7316_RS09405	COG0583	DNA-binding transcription factor activity
D7316_RS09410	COG4638	Rieske (2fe-2S)
D7316_RS09435	COG2827	Endonuclease containing a URI domain
D7316_RS09450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7316_RS09455	COG0183	Belongs to the thiolase family
D7316_RS09460	COG0583	DNA-binding transcription factor activity
D7316_RS09465	COG1017	nitric oxide dioxygenase activity
D7316_RS09465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7316_RS09490	COG2094	Belongs to the DNA glycosylase MPG family
D7316_RS09500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7316_RS09540	COG0492	ferredoxin-NADP+ reductase activity
D7316_RS09555	COG4152	abc transporter atp-binding protein
D7316_RS09565	COG1024	Enoyl-CoA hydratase
D7316_RS09570	COG0415	Belongs to the DNA photolyase family
D7316_RS09575	COG0545	Peptidyl-prolyl cis-trans isomerase
D7316_RS09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7316_RS09595	COG1984	allophanate hydrolase subunit 2
D7316_RS09615	COG0259	pyridoxamine-phosphate oxidase activity
D7316_RS09630	COG1131	(ABC) transporter
D7316_RS09635	COG1309	transcriptional regulator
D7316_RS09675	COG1846	Transcriptional regulator
D7316_RS09680	COG2252	PERMEase
D7316_RS09695	COG0656	L-ascorbic acid biosynthetic process
D7316_RS09740	COG1024	Enoyl-CoA hydratase
D7316_RS09745	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09750	COG1024	Enoyl-CoA hydratase
D7316_RS09765	COG1902	pentaerythritol trinitrate reductase activity
D7316_RS09775	COG1024	Enoyl-CoA hydratase
D7316_RS09780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7316_RS09785	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09790	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09795	COG0398	Pfam SNARE associated Golgi protein
D7316_RS09800	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09805	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09815	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09825	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09830	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09835	COG1024	Enoyl-CoA hydratase
D7316_RS09850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS09855	COG1946	Acyl-CoA thioesterase
D7316_RS09860	COG2186	Transcriptional regulator
D7316_RS09895	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS09925	COG0673	inositol 2-dehydrogenase activity
D7316_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS09950	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09955	COG1960	acyl-CoA dehydrogenase activity
D7316_RS09960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS09965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS09970	COG1309	transcriptional regulator
D7316_RS09990	COG1309	transcriptional regulator
D7316_RS09995	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS10005	COG1024	Enoyl-CoA hydratase
D7316_RS10010	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10015	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10020	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10025	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10030	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10035	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10045	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10050	COG0183	Belongs to the thiolase family
D7316_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS10100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7316_RS10100	COG0596	Alpha beta hydrolase
D7316_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10130	COG0183	Belongs to the thiolase family
D7316_RS10145	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS10165	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS10185	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10190	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS10220	COG0183	Belongs to the thiolase family
D7316_RS10225	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10235	COG1024	Enoyl-CoA hydratase
D7316_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS10300	COG1609	Transcriptional regulator
D7316_RS10305	COG0183	Belongs to the thiolase family
D7316_RS10315	COG0667	Aldo Keto reductase
D7316_RS10320	COG1024	Enoyl-CoA hydratase
D7316_RS10325	COG0300	oxidoreductase activity
D7316_RS10330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10360	COG1024	Enoyl-CoA hydratase
D7316_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10395	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10410	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS10415	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS10450	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7316_RS10450	COG0596	Alpha beta hydrolase
D7316_RS10455	COG3971	2-oxopent-4-enoate hydratase activity
D7316_RS10465	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10470	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10515	COG1063	alcohol dehydrogenase
D7316_RS10535	COG1024	Enoyl-CoA hydratase
D7316_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS10620	COG1309	transcriptional regulator
D7316_RS10635	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS10655	COG1024	Enoyl-CoA hydratase
D7316_RS10660	COG1355	regulation of microtubule-based process
D7316_RS10685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7316_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10695	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS10700	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10705	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10720	COG2267	carboxylic ester hydrolase activity
D7316_RS10735	COG0671	phosphoesterase, PA-phosphatase related
D7316_RS10740	COG2409	Drug exporters of the RND superfamily
D7316_RS10750	COG1960	acyl-CoA dehydrogenase activity
D7316_RS10770	COG2814	Major facilitator Superfamily
D7316_RS10780	COG1278	Cold shock
D7316_RS10820	COG0521	Mo-molybdopterin cofactor biosynthetic process
D7316_RS10840	COG1690	Belongs to the RtcB family
D7316_RS10860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS10880	COG2072	flavoprotein involved in K transport
D7316_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10895	COG1309	transcriptional regulator
D7316_RS10900	COG2409	Drug exporters of the RND superfamily
D7316_RS10925	COG2353	YceI-like domain
D7316_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS10975	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11035	COG4974	Belongs to the 'phage' integrase family
D7316_RS11085	COG4221	oxidoreductase activity
D7316_RS11095	COG2186	Transcriptional regulator
D7316_RS11100	COG0247	lactate metabolic process
D7316_RS11105	COG1139	Iron-sulfur cluster binding protein
D7316_RS11110	COG1556	Lactate utilization protein
D7316_RS11150	COG4948	Mandelate Racemase Muconate Lactonizing
D7316_RS11155	COG2188	Transcriptional regulator
D7316_RS11170	COG2030	dehydratase
D7316_RS11175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS11185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7316_RS11190	COG1024	Enoyl-CoA hydratase
D7316_RS11200	COG0583	DNA-binding transcription factor activity
D7316_RS11205	COG0183	Belongs to the thiolase family
D7316_RS11215	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11230	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11240	COG0183	Belongs to the thiolase family
D7316_RS11245	COG2271	Major facilitator Superfamily
D7316_RS11250	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11255	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11290	COG1316	TRANSCRIPTIONal
D7316_RS11340	COG0003	Pfam Anion-transporting ATPase
D7316_RS11395	COG0454	-acetyltransferase
D7316_RS11395	COG0456	acetyltransferase
D7316_RS11400	COG0745	RESPONSE REGULATOR receiver
D7316_RS11410	COG2897	thiosulfate sulfurtransferase activity
D7316_RS11425	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D7316_RS11435	COG4988	ABC transporter
D7316_RS11440	COG4988	ABC transporter
D7316_RS11445	COG1294	oxidase, subunit
D7316_RS11450	COG1271	oxidase subunit
D7316_RS11475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D7316_RS11505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7316_RS11510	COG1024	Enoyl-CoA hydratase
D7316_RS11515	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS11590	COG2084	Dehydrogenase
D7316_RS11595	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS11605	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS11630	COG1024	Enoyl-CoA hydratase
D7316_RS11645	COG1309	transcriptional regulator
D7316_RS11660	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11665	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11670	COG0183	Belongs to the thiolase family
D7316_RS11675	COG1024	Enoyl-CoA hydratase
D7316_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS11730	COG4638	Rieske (2fe-2S)
D7316_RS11750	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11775	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11800	COG1703	isobutyryl-CoA mutase activity
D7316_RS11805	COG0183	Belongs to the thiolase family
D7316_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS11835	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11840	COG1960	acyl-CoA dehydrogenase activity
D7316_RS11845	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS11860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS11870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7316_RS11875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7316_RS11875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7316_RS11910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7316_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS11935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS11940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS11985	COG1956	GAF domain-containing protein
D7316_RS11990	COG1218	3'(2'),5'-bisphosphate nucleotidase
D7316_RS12040	COG1024	Enoyl-CoA hydratase
D7316_RS12045	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12050	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12055	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12060	COG3548	integral membrane protein
D7316_RS12080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7316_RS12085	COG0346	lactoylglutathione lyase activity
D7316_RS12090	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D7316_RS12140	COG1141	Ferredoxin
D7316_RS12145	COG4638	Rieske (2fe-2S)
D7316_RS12150	COG0346	lactoylglutathione lyase activity
D7316_RS12175	COG1335	isochorismatase
D7316_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12245	COG0183	Belongs to the thiolase family
D7316_RS12255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS12260	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12270	COG1024	Enoyl-CoA hydratase
D7316_RS12275	COG0604	alcohol dehydrogenase
D7316_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12310	COG2259	Doxx family
D7316_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12360	COG0492	ferredoxin-NADP+ reductase activity
D7316_RS12365	COG2267	carboxylic ester hydrolase activity
D7316_RS12380	COG1024	Enoyl-CoA hydratase
D7316_RS12385	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12390	COG2084	Dehydrogenase
D7316_RS12410	COG0183	Belongs to the thiolase family
D7316_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS12420	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12425	COG1024	Enoyl-CoA hydratase
D7316_RS12450	COG1946	Acyl-CoA thioesterase
D7316_RS12455	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12460	COG1024	Enoyl-CoA hydratase
D7316_RS12470	COG2186	Transcriptional regulator
D7316_RS12485	COG1053	succinate dehydrogenase
D7316_RS12500	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D7316_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12525	COG1309	transcriptional regulator
D7316_RS12550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7316_RS12560	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12565	COG0022	dehydrogenase e1 component
D7316_RS12570	COG1024	Enoyl-CoA hydratase
D7316_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12590	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS12610	COG2814	Major facilitator Superfamily
D7316_RS12615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7316_RS12620	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D7316_RS12625	COG3971	2-oxopent-4-enoate hydratase activity
D7316_RS12645	COG0346	lactoylglutathione lyase activity
D7316_RS12655	COG0657	acetylesterase activity
D7316_RS12665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7316_RS12680	COG3631	Ketosteroid isomerase-related protein
D7316_RS12685	COG1053	succinate dehydrogenase
D7316_RS12705	COG3976	FMN-binding domain protein
D7316_RS12705	COG1053	succinate dehydrogenase
D7316_RS12715	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12735	COG1053	succinate dehydrogenase
D7316_RS12740	COG2030	dehydratase
D7316_RS12745	COG1309	transcriptional regulator
D7316_RS12760	COG0477	Major facilitator Superfamily
D7316_RS12765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D7316_RS12785	COG2030	dehydratase
D7316_RS12790	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12795	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12800	COG1960	acyl-CoA dehydrogenase activity
D7316_RS12805	COG1309	transcriptional regulator
D7316_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS12825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7316_RS12840	COG1024	Enoyl-CoA hydratase
D7316_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS12870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7316_RS12875	COG2151	metal-sulfur cluster biosynthetic enzyme
D7316_RS12880	COG3396	Phenylacetate-CoA oxygenase
D7316_RS12885	COG3460	Phenylacetate-CoA oxygenase
D7316_RS12890	COG3396	Phenylacetate-CoA oxygenase
D7316_RS12895	COG1024	Enoyl-CoA hydratase
D7316_RS12900	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7316_RS12910	COG1309	transcriptional regulator
D7316_RS12915	COG2030	dehydratase
D7316_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS12960	COG2378	regulation of single-species biofilm formation
D7316_RS12970	COG2814	Major facilitator Superfamily
D7316_RS13000	COG1024	Enoyl-CoA hydratase
D7316_RS13025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D7316_RS13030	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS13065	COG1733	regulation of RNA biosynthetic process
D7316_RS13070	COG0702	epimerase
D7316_RS13080	COG0702	epimerase
D7316_RS13095	COG1362	aminopeptidase activity
D7316_RS13105	COG0047	phosphoribosylformylglycinamidine synthase activity
D7316_RS13110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7316_RS13115	COG0386	Belongs to the glutathione peroxidase family
D7316_RS13125	COG0477	Major facilitator Superfamily
D7316_RS13135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D7316_RS13145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7316_RS13170	COG1937	Protein conserved in bacteria
D7316_RS13195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D7316_RS13200	COG1216	Glycosyl transferase, family 2
D7316_RS13230	COG2205	protein histidine kinase activity
D7316_RS13235	COG0745	RESPONSE REGULATOR receiver
D7316_RS13260	COG2272	Belongs to the type-B carboxylesterase lipase family
D7316_RS13265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7316_RS13280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D7316_RS13295	COG1305	Transglutaminase-like
D7316_RS13325	COG0492	ferredoxin-NADP+ reductase activity
D7316_RS13330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D7316_RS13370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7316_RS13375	COG2267	carboxylic ester hydrolase activity
D7316_RS13400	COG2733	membrane
D7316_RS13415	COG2326	polyphosphate kinase activity
D7316_RS13420	COG3135	benzoate transporter
D7316_RS13440	COG2224	Isocitrate lyase
D7316_RS13510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7316_RS13520	COG1505	serine-type exopeptidase activity
D7316_RS13530	COG1136	(ABC) transporter
D7316_RS13530	COG0577	efflux transmembrane transporter activity
D7316_RS13540	COG2326	polyphosphate kinase activity
D7316_RS13575	COG2365	Tyrosine phosphatase family
D7316_RS13580	COG0459	protein refolding
D7316_RS13595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7316_RS13610	COG1136	(ABC) transporter
D7316_RS13620	COG4585	Histidine kinase
D7316_RS13625	COG2197	response regulator
D7316_RS13650	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7316_RS13665	COG3275	phosphorelay sensor kinase activity
D7316_RS13680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7316_RS13690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7316_RS13695	COG0154	amidase activity
D7316_RS13715	COG1960	acyl-CoA dehydrogenase activity
D7316_RS13720	COG1960	acyl-CoA dehydrogenase activity
D7316_RS13725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS13730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS13735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS13740	COG3766	membrane
D7316_RS13750	COG0647	UMP catabolic process
D7316_RS13760	COG0688	phosphatidylethanolamine metabolic process
D7316_RS13770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7316_RS13800	COG2111	Na H antiporter
D7316_RS13800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7316_RS13805	COG1006	Multisubunit Na H antiporter MnhC subunit
D7316_RS13810	COG0651	ATP synthesis coupled electron transport
D7316_RS13820	COG2212	antiporter activity
D7316_RS13825	COG1320	monovalent cation:proton antiporter activity
D7316_RS13835	COG2032	superoxide dismutase activity
D7316_RS13850	COG0242	peptide deformylase activity
D7316_RS13905	COG2124	cytochrome p450
D7316_RS13910	COG2814	Major facilitator Superfamily
D7316_RS13915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7316_RS13930	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7316_RS13935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7316_RS13945	COG0148	phosphopyruvate hydratase activity
D7316_RS13950	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7316_RS13985	COG1063	alcohol dehydrogenase
D7316_RS13995	COG1506	peptidase
D7316_RS13995	COG0823	Involved in the tonB-independent uptake of proteins
D7316_RS14015	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7316_RS14020	COG0346	lactoylglutathione lyase activity
D7316_RS14045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D7316_RS14050	COG0019	diaminopimelate decarboxylase activity
D7316_RS14065	COG0747	negative chemotaxis
D7316_RS14080	COG4172	Belongs to the ABC transporter superfamily
D7316_RS14095	COG0657	acetylesterase activity
D7316_RS14100	COG0586	Pfam SNARE associated Golgi protein
D7316_RS14125	COG0672	)-iron permease
D7316_RS14130	COG2205	protein histidine kinase activity
D7316_RS14140	COG0745	RESPONSE REGULATOR receiver
D7316_RS14170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS14200	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D7316_RS14205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS14205	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D7316_RS14215	COG1021	2,3-dihydroxybenzoate-AMP ligase
D7316_RS14235	COG1132	(ABC) transporter
D7316_RS14240	COG1132	(ABC) transporter
D7316_RS14245	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D7316_RS14255	COG2375	cellular response to nickel ion
D7316_RS14255	COG1132	(ABC) transporter
D7316_RS14265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D7316_RS14270	COG0351	phosphomethylpyrimidine kinase
D7316_RS14310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS14315	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D7316_RS14320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7316_RS14385	COG1960	acyl-CoA dehydrogenase activity
D7316_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS14425	COG2030	dehydratase
D7316_RS14430	COG0586	Pfam SNARE associated Golgi protein
D7316_RS14440	COG1309	transcriptional regulator
D7316_RS14480	COG1472	Belongs to the glycosyl hydrolase 3 family
D7316_RS14515	COG2301	Belongs to the HpcH HpaI aldolase family
D7316_RS14540	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS14565	COG0577	efflux transmembrane transporter activity
D7316_RS14565	COG1136	(ABC) transporter
D7316_RS14575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D7316_RS14595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D7316_RS14610	COG2197	response regulator
D7316_RS14615	COG4585	Histidine kinase
D7316_RS14650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7316_RS14655	COG3590	peptidase
D7316_RS14675	COG2409	Drug exporters of the RND superfamily
D7316_RS14680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7316_RS14685	COG2267	carboxylic ester hydrolase activity
D7316_RS14695	COG1024	Enoyl-CoA hydratase
D7316_RS14695	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7316_RS14700	COG0183	Belongs to the thiolase family
D7316_RS14705	COG1309	transcriptional regulator
D7316_RS14710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D7316_RS14765	COG4221	oxidoreductase activity
D7316_RS14780	COG1309	transcriptional regulator
D7316_RS14800	COG2409	Drug exporters of the RND superfamily
D7316_RS14845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7316_RS14855	COG1079	Belongs to the binding-protein-dependent transport system permease family
D7316_RS14860	COG4603	Belongs to the binding-protein-dependent transport system permease family
D7316_RS14865	COG3845	ABC transporter
D7316_RS14870	COG1744	ABC transporter substrate-binding protein PnrA-like
D7316_RS14880	COG0659	secondary active sulfate transmembrane transporter activity
D7316_RS14915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7316_RS14935	COG1937	Protein conserved in bacteria
D7316_RS14960	COG2217	Heavy metal translocating P-type atpase
D7316_RS14975	COG1064	alcohol dehydrogenase
D7316_RS14985	COG0640	Transcriptional regulator
D7316_RS15000	COG1121	(ABC) transporter
D7316_RS15005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7316_RS15105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7316_RS15110	COG0328	RNA-DNA hybrid ribonuclease activity
D7316_RS15115	COG4106	trans-aconitate 2-methyltransferase activity
D7316_RS15130	COG0372	Belongs to the citrate synthase family
D7316_RS15150	COG0038	chloride channel
D7316_RS15165	COG1846	Transcriptional regulator
D7316_RS15175	COG0583	DNA-binding transcription factor activity
D7316_RS15185	COG1832	CoA-binding protein
D7316_RS15245	COG1252	NADH dehydrogenase
D7316_RS15260	COG2072	flavoprotein involved in K transport
D7316_RS15265	COG2508	Transcriptional regulator
D7316_RS15270	COG2301	Belongs to the HpcH HpaI aldolase family
D7316_RS15275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS15280	COG0693	protein deglycase activity
D7316_RS15310	COG0183	Belongs to the thiolase family
D7316_RS15315	COG1309	transcriptional regulator
D7316_RS15320	COG1960	acyl-CoA dehydrogenase activity
D7316_RS15340	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS15355	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS15365	COG3243	poly(R)-hydroxyalkanoic acid synthase
D7316_RS15370	COG1414	Transcriptional regulator
D7316_RS15380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7316_RS15390	COG3485	protocatechuate 3,4-dioxygenase
D7316_RS15395	COG3485	protocatechuate 3,4-dioxygenase
D7316_RS15410	COG0069	glutamate synthase activity
D7316_RS15415	COG2218	PFAM glutamate synthase alpha subunit domain protein
D7316_RS15420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D7316_RS15430	COG0583	DNA-binding transcription factor activity
D7316_RS15440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7316_RS15445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS15450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7316_RS15455	COG1024	Enoyl-CoA hydratase
D7316_RS15460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7316_RS15470	COG1297	OPT oligopeptide transporter protein
D7316_RS15475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D7316_RS15490	COG2272	Belongs to the type-B carboxylesterase lipase family
D7316_RS15510	COG1609	Transcriptional regulator
D7316_RS15520	COG1082	Xylose isomerase domain protein TIM barrel
D7316_RS15530	COG1082	Xylose isomerase domain protein TIM barrel
D7316_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15550	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15565	COG2814	Major facilitator Superfamily
D7316_RS15570	COG1940	carbohydrate kinase activity
D7316_RS15590	COG0386	Belongs to the glutathione peroxidase family
D7316_RS15615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS15625	COG1414	Transcriptional regulator
D7316_RS15630	COG1058	Belongs to the CinA family
D7316_RS15630	COG1546	Belongs to the CinA family
D7316_RS15650	COG0142	geranyltranstransferase activity
D7316_RS15685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D7316_RS15705	COG0583	DNA-binding transcription factor activity
D7316_RS15710	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15760	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15770	COG0477	Major facilitator Superfamily
D7316_RS15795	COG2223	nitrite transmembrane transporter activity
D7316_RS15800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7316_RS15805	COG1960	acyl-CoA dehydrogenase activity
D7316_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15815	COG0537	adenosine 5'-monophosphoramidase activity
D7316_RS15840	COG1024	Enoyl-CoA hydratase
D7316_RS15845	COG2186	Transcriptional regulator
D7316_RS15865	COG0427	acetyl-CoA hydrolase
D7316_RS15870	COG0183	Belongs to the thiolase family
D7316_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS15885	COG1960	acyl-CoA dehydrogenase activity
D7316_RS15890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7316_RS15895	COG1960	acyl-CoA dehydrogenase activity
D7316_RS15910	COG0604	alcohol dehydrogenase
D7316_RS15910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS15910	COG3321	synthase
D7316_RS15910	COG4221	oxidoreductase activity
D7316_RS15920	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS15930	COG2197	response regulator
D7316_RS15940	COG0633	Ferredoxin
D7316_RS15965	COG2030	dehydratase
D7316_RS15970	COG5280	Phage tail tape measure protein TP901
D7316_RS15970	COG3953	SLT domain
D7316_RS15985	COG2080	2 iron, 2 sulfur cluster binding
D7316_RS15990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D7316_RS15995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7316_RS16000	COG0069	glutamate synthase activity
D7316_RS16015	COG2271	Major facilitator Superfamily
D7316_RS16050	COG4638	Rieske (2fe-2S)
D7316_RS16065	COG3852	Histidine kinase
D7316_RS16075	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS16100	COG1609	Transcriptional regulator
D7316_RS16105	COG2814	Major facilitator Superfamily
D7316_RS16110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7316_RS16110	COG0596	Alpha beta hydrolase
D7316_RS16135	COG2070	2-Nitropropane dioxygenase
D7316_RS16145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7316_RS16145	COG1017	nitric oxide dioxygenase activity
D7316_RS16150	COG0561	phosphatase activity
D7316_RS16195	COG0305	Participates in initiation and elongation during chromosome replication
D7316_RS16210	COG0359	binds to the 23S rRNA
D7316_RS16215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7316_RS16225	COG0360	Binds together with S18 to 16S ribosomal RNA
D7316_RS16245	COG0604	alcohol dehydrogenase
D7316_RS16260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7316_RS16275	COG1260	myo-inositol-1-phosphate synthase
D7316_RS16290	COG3321	synthase
D7316_RS16290	COG0604	alcohol dehydrogenase
D7316_RS16295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D7316_RS16315	COG1793	dna ligase
D7316_RS16320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7316_RS16325	COG1253	flavin adenine dinucleotide binding
D7316_RS16340	COG0343	queuine tRNA-ribosyltransferase activity
D7316_RS16350	COG0789	Transcriptional regulator
D7316_RS16355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7316_RS16375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7316_RS16380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7316_RS16385	COG0649	NAD binding
D7316_RS16395	COG1034	ATP synthesis coupled electron transport
D7316_RS16400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D7316_RS16405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7316_RS16460	COG0590	tRNA wobble adenosine to inosine editing
D7316_RS16470	COG0287	Prephenate dehydrogenase
D7316_RS16535	COG0598	Magnesium transport protein CorA
D7316_RS16540	COG1733	regulation of RNA biosynthetic process
D7316_RS16560	COG2814	Major facilitator Superfamily
D7316_RS16575	COG2072	flavoprotein involved in K transport
D7316_RS16580	COG2267	carboxylic ester hydrolase activity
D7316_RS16605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7316_RS16610	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS16620	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS16670	COG1216	Glycosyl transferase, family 2
D7316_RS16675	COG0477	Major facilitator Superfamily
D7316_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS16780	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS16875	COG0277	FAD linked oxidase domain protein
D7316_RS16880	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS16890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7316_RS16900	COG0640	Transcriptional regulator
D7316_RS16975	COG0783	Belongs to the Dps family
D7316_RS16985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7316_RS16990	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D7316_RS16990	COG3321	synthase
D7316_RS16990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7316_RS16995	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS17005	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D7316_RS17020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7316_RS17025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D7316_RS17030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D7316_RS17035	COG0671	phosphoesterase, PA-phosphatase related
D7316_RS17040	COG1216	Glycosyl transferase, family 2
D7316_RS17060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7316_RS17065	COG0500	methyltransferase
D7316_RS17075	COG2385	sporulation resulting in formation of a cellular spore
D7316_RS17085	COG1595	DNA-templated transcription, initiation
D7316_RS17100	COG1131	(ABC) transporter
D7316_RS17100	COG0842	Transport permease protein
D7316_RS17100	COG1716	ATPase activity
D7316_RS17105	COG0443	Heat shock 70 kDa protein
D7316_RS17130	COG0561	phosphatase activity
D7316_RS17190	COG0406	alpha-ribazole phosphatase activity
D7316_RS17195	COG0077	Prephenate dehydratase
D7316_RS17220	COG1316	TRANSCRIPTIONal
D7316_RS17225	COG1528	Iron-storage protein
D7316_RS17245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7316_RS17270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D7316_RS17295	COG2119	membrane
D7316_RS17345	COG0596	Alpha beta hydrolase
D7316_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS17385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7316_RS17385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D7316_RS17390	COG2501	S4 domain
D7316_RS17420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS17420	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D7316_RS17430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7316_RS17445	COG0069	glutamate synthase activity
D7316_RS17445	COG0067	glutamate synthase
D7316_RS17445	COG0070	glutamate synthase
D7316_RS17450	COG0657	acetylesterase activity
D7316_RS17500	COG4585	Histidine kinase
D7316_RS17520	COG2814	Major facilitator Superfamily
D7316_RS17535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7316_RS17550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7316_RS17565	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS17580	COG1846	Transcriptional regulator
D7316_RS17585	COG2814	Major facilitator Superfamily
D7316_RS17600	COG3246	L-lysine catabolic process to acetate
D7316_RS17605	COG2175	clavaminate synthase activity
D7316_RS17620	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D7316_RS17625	COG4221	oxidoreductase activity
D7316_RS17630	COG3631	Ketosteroid isomerase-related protein
D7316_RS17660	COG0714	Associated with various cellular activities
D7316_RS17690	COG1309	transcriptional regulator
D7316_RS17705	COG1960	acyl-CoA dehydrogenase activity
D7316_RS17715	COG0495	leucyl-tRNA aminoacylation
D7316_RS17755	COG1678	Uncharacterized ACR, COG1678
D7316_RS17770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7316_RS17795	COG0617	tRNA 3'-terminal CCA addition
D7316_RS17835	COG1595	DNA-templated transcription, initiation
D7316_RS17855	COG3409	Peptidoglycan-binding domain 1 protein
D7316_RS17855	COG0860	N-Acetylmuramoyl-L-alanine amidase
D7316_RS17870	COG1192	Involved in chromosome partitioning
D7316_RS17875	COG0357	Ribosomal RNA small subunit methyltransferase G
D7316_RS17885	COG0706	membrane insertase activity
D7316_RS17890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D7316_RS17895	COG0594	ribonuclease P activity
D7316_RS17905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7316_RS17910	COG0592	DNA-directed DNA polymerase activity
D7316_RS17915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D7316_RS17920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D7316_RS17925	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D7316_RS17930	COG0187	DNA topoisomerase II activity
D7316_RS17985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D7316_RS17990	COG0705	Rhomboid family
D7316_RS18015	COG0515	serine threonine protein kinase
D7316_RS18020	COG0768	penicillin binding
D7316_RS18035	COG1716	ATPase activity
D7316_RS18040	COG1716	ATPase activity
D7316_RS18050	COG4221	oxidoreductase activity
D7316_RS18060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS18085	COG4221	oxidoreductase activity
D7316_RS18105	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS18115	COG3119	arylsulfatase activity
D7316_RS18120	COG4424	Sulfotransferase
D7316_RS18165	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS18185	COG2197	response regulator
D7316_RS18215	COG0747	negative chemotaxis
D7316_RS18220	COG0601	transmembrane transport
D7316_RS18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS18240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7316_RS18250	COG2072	flavoprotein involved in K transport
D7316_RS18295	COG0492	ferredoxin-NADP+ reductase activity
D7316_RS18305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7316_RS18310	COG1309	transcriptional regulator
D7316_RS18320	COG1309	transcriptional regulator
D7316_RS18330	COG2030	dehydratase
D7316_RS18350	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS18365	COG0768	penicillin binding
D7316_RS18375	COG0583	DNA-binding transcription factor activity
D7316_RS18395	COG0583	DNA-binding transcription factor activity
D7316_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS18435	COG1073	alpha beta
D7316_RS18505	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS18520	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D7316_RS18570	COG2267	carboxylic ester hydrolase activity
D7316_RS18600	COG2354	Protein conserved in bacteria
D7316_RS18625	COG1757	Na H antiporter
D7316_RS18630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7316_RS18635	COG1396	sequence-specific DNA binding
D7316_RS18760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7316_RS18775	COG0789	Transcriptional regulator
D7316_RS18855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D7316_RS18870	COG0028	Belongs to the TPP enzyme family
D7316_RS18880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D7316_RS18900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7316_RS18905	COG4948	Mandelate Racemase Muconate Lactonizing
D7316_RS18910	COG0583	DNA-binding transcription factor activity
D7316_RS18915	COG0589	response to stress
D7316_RS18920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7316_RS18925	COG0747	negative chemotaxis
D7316_RS18930	COG0601	transmembrane transport
D7316_RS18935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS18940	COG0444	Belongs to the ABC transporter superfamily
D7316_RS18945	COG4608	Belongs to the ABC transporter superfamily
D7316_RS18955	COG4948	Mandelate Racemase Muconate Lactonizing
D7316_RS18960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7316_RS19010	COG1609	Transcriptional regulator
D7316_RS19015	COG1070	Carbohydrate kinase
D7316_RS19020	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS19020	COG3347	Dehydrogenase
D7316_RS19055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D7316_RS19065	COG0243	molybdopterin cofactor binding
D7316_RS19070	COG2318	DinB family
D7316_RS19075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7316_RS19080	COG2197	response regulator
D7316_RS19095	COG3284	Transcriptional regulator
D7316_RS19100	COG2072	flavoprotein involved in K transport
D7316_RS19110	COG2197	response regulator
D7316_RS19130	COG1793	dna ligase
D7316_RS19135	COG5343	regulation of RNA biosynthetic process
D7316_RS19140	COG1595	DNA-templated transcription, initiation
D7316_RS19150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7316_RS19165	COG3304	Inner membrane component domain
D7316_RS19200	COG2890	protein-(glutamine-N5) methyltransferase activity
D7316_RS19205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7316_RS19210	COG2851	Citrate transporter
D7316_RS19215	COG3290	protein histidine kinase activity
D7316_RS19220	COG4565	transcriptional regulatory protein
D7316_RS19230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7316_RS19230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D7316_RS19235	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D7316_RS19260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7316_RS19265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7316_RS19270	COG0187	DNA topoisomerase II activity
D7316_RS19285	COG1609	Transcriptional regulator
D7316_RS19290	COG3119	arylsulfatase activity
D7316_RS19295	COG0659	secondary active sulfate transmembrane transporter activity
D7316_RS19320	COG1116	anion transmembrane transporter activity
D7316_RS19330	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS19400	COG2271	Major facilitator Superfamily
D7316_RS19405	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS19420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7316_RS19425	COG5650	phosphatidylinositol metabolic process
D7316_RS19440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7316_RS19455	COG0564	pseudouridine synthase activity
D7316_RS19465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D7316_RS19470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7316_RS19490	COG3442	glutamine amidotransferase
D7316_RS19495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D7316_RS19500	COG0657	acetylesterase activity
D7316_RS19510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS19595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7316_RS19620	COG0477	Major facilitator Superfamily
D7316_RS19655	COG3265	gluconokinase activity
D7316_RS19680	COG0402	S-adenosylhomocysteine deaminase activity
D7316_RS19695	COG1764	response to oxidative stress
D7316_RS19735	COG0477	Major facilitator Superfamily
D7316_RS19805	COG1024	Enoyl-CoA hydratase
D7316_RS19820	COG1408	metallophosphoesterase
D7316_RS19825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7316_RS19860	COG2814	Major facilitator Superfamily
D7316_RS19870	COG2268	Band 7 protein
D7316_RS19895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7316_RS19900	COG0494	nUDIX hydrolase
D7316_RS19910	COG0596	Alpha beta hydrolase
D7316_RS19920	COG0789	Transcriptional regulator
D7316_RS19930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7316_RS19990	COG1111	helicase
D7316_RS19990	COG1205	dead DEAH box helicase
D7316_RS19995	COG1278	Cold shock
D7316_RS20005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7316_RS20005	COG1754	DNA topoisomerase type I activity
D7316_RS20020	COG1116	anion transmembrane transporter activity
D7316_RS20080	COG2154	pterin-4-alpha-carbinolamine dehydratase
D7316_RS20105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7316_RS20115	COG1088	dTDP-glucose 4,6-dehydratase activity
D7316_RS20165	COG0657	acetylesterase activity
D7316_RS20185	COG1132	(ABC) transporter
D7316_RS20190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS20195	COG0583	DNA-binding transcription factor activity
D7316_RS20210	COG1309	transcriptional regulator
D7316_RS20215	COG0277	FAD linked oxidase domain protein
D7316_RS20225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7316_RS20230	COG0515	serine threonine protein kinase
D7316_RS20235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7316_RS20265	COG0352	thiamine-phosphate diphosphorylase activity
D7316_RS20270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7316_RS20270	COG2022	thiamine diphosphate biosynthetic process
D7316_RS20280	COG2022	thiamine diphosphate biosynthetic process
D7316_RS20310	COG3830	Belongs to the UPF0237 family
D7316_RS20310	COG0560	Phosphoserine phosphatase
D7316_RS20345	COG0402	S-adenosylhomocysteine deaminase activity
D7316_RS20350	COG0659	secondary active sulfate transmembrane transporter activity
D7316_RS20360	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D7316_RS20370	COG0477	Major facilitator Superfamily
D7316_RS20410	COG2814	Major facilitator Superfamily
D7316_RS20415	COG0589	response to stress
D7316_RS20420	COG2124	cytochrome p450
D7316_RS20425	COG0667	Aldo Keto reductase
D7316_RS20460	COG3226	Transcriptional regulator
D7316_RS20465	COG2814	Major facilitator Superfamily
D7316_RS20470	COG2353	YceI-like domain
D7316_RS20495	COG0745	RESPONSE REGULATOR receiver
D7316_RS20500	COG2205	protein histidine kinase activity
D7316_RS20555	COG4221	oxidoreductase activity
D7316_RS20570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D7316_RS20590	COG0477	Major facilitator Superfamily
D7316_RS20615	COG0247	lactate metabolic process
D7316_RS20615	COG2181	nitrate reductase activity
D7316_RS20660	COG2264	protein methyltransferase activity
D7316_RS20705	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D7316_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS20720	COG3268	Saccharopine dehydrogenase
D7316_RS20725	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS20730	COG3387	PFAM Glycoside hydrolase 15-related
D7316_RS20735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7316_RS20740	COG0596	Alpha beta hydrolase
D7316_RS20795	COG0443	Heat shock 70 kDa protein
D7316_RS20800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7316_RS20805	COG0484	heat shock protein binding
D7316_RS20810	COG0789	Transcriptional regulator
D7316_RS20845	COG0277	FAD linked oxidase domain protein
D7316_RS20860	COG1960	acyl-CoA dehydrogenase activity
D7316_RS20865	COG1309	transcriptional regulator
D7316_RS20875	COG2267	carboxylic ester hydrolase activity
D7316_RS20925	COG0656	L-ascorbic acid biosynthetic process
D7316_RS20985	COG2072	flavoprotein involved in K transport
D7316_RS20990	COG1960	acyl-CoA dehydrogenase activity
D7316_RS20995	COG1960	acyl-CoA dehydrogenase activity
D7316_RS21000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS21015	COG2267	carboxylic ester hydrolase activity
D7316_RS21025	COG1024	Enoyl-CoA hydratase
D7316_RS21030	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS21045	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS21060	COG4638	Rieske (2fe-2S)
D7316_RS21065	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS21080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS21085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS21165	COG0243	molybdopterin cofactor binding
D7316_RS21170	COG0243	molybdopterin cofactor binding
D7316_RS21180	COG0243	molybdopterin cofactor binding
D7316_RS21195	COG1024	Enoyl-CoA hydratase
D7316_RS21200	COG0183	Belongs to the thiolase family
D7316_RS21225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS21235	COG0477	Major facilitator Superfamily
D7316_RS21240	COG1960	acyl-CoA dehydrogenase activity
D7316_RS21245	COG0456	acetyltransferase
D7316_RS21245	COG0454	-acetyltransferase
D7316_RS21260	COG1024	Enoyl-CoA hydratase
D7316_RS21275	COG0673	inositol 2-dehydrogenase activity
D7316_RS21290	COG2197	response regulator
D7316_RS21295	COG4585	Histidine kinase
D7316_RS21310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7316_RS21315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7316_RS21320	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D7316_RS21345	COG5285	phytanoyl-CoA dioxygenase
D7316_RS21375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7316_RS21395	COG0702	epimerase
D7316_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS21425	COG2116	formate transmembrane transporter activity
D7316_RS21440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS21455	COG0596	Alpha beta hydrolase
D7316_RS21465	COG1408	metallophosphoesterase
D7316_RS21470	COG2271	Major facilitator Superfamily
D7316_RS21475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS21485	COG0747	negative chemotaxis
D7316_RS21490	COG0601	transmembrane transport
D7316_RS21495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS21500	COG4172	Belongs to the ABC transporter superfamily
D7316_RS21525	COG0667	Aldo Keto reductase
D7316_RS21530	COG0667	Aldo Keto reductase
D7316_RS21535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS21540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS21575	COG0542	response to heat
D7316_RS21580	COG2318	DinB family
D7316_RS21590	COG2376	Dihydroxyacetone kinase
D7316_RS21600	COG3387	PFAM Glycoside hydrolase 15-related
D7316_RS21605	COG0604	alcohol dehydrogenase
D7316_RS21610	COG2818	Glycosylase
D7316_RS21640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D7316_RS21645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D7316_RS21650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D7316_RS21685	COG0477	Major facilitator Superfamily
D7316_RS21690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7316_RS21695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7316_RS21700	COG0006	proline dipeptidase activity
D7316_RS21715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7316_RS21725	COG0693	protein deglycase activity
D7316_RS21730	COG0477	Major facilitator Superfamily
D7316_RS21735	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7316_RS21750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7316_RS21760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7316_RS21765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7316_RS21790	COG0586	Pfam SNARE associated Golgi protein
D7316_RS21825	COG4129	membrane
D7316_RS21840	COG1994	Peptidase M50
D7316_RS21890	COG1120	ATPase activity
D7316_RS21895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS21900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7316_RS21955	COG4266	Belongs to the allantoicase family
D7316_RS21960	COG1846	Transcriptional regulator
D7316_RS21975	COG2027	D-alanyl-D-alanine carboxypeptidase
D7316_RS21985	COG0037	tRNA processing
D7316_RS22005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7316_RS22010	COG0302	gtp cyclohydrolase
D7316_RS22015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7316_RS22020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7316_RS22045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D7316_RS22050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D7316_RS22055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D7316_RS22075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7316_RS22085	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS22090	COG1960	acyl-CoA dehydrogenase activity
D7316_RS22100	COG0183	Belongs to the thiolase family
D7316_RS22105	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS22110	COG1309	transcriptional regulator
D7316_RS22130	COG0604	alcohol dehydrogenase
D7316_RS22135	COG3835	regulator
D7316_RS22145	COG2233	PERMEase
D7316_RS22165	COG1024	Enoyl-CoA hydratase
D7316_RS22190	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS22195	COG2124	cytochrome p450
D7316_RS22200	COG2124	cytochrome p450
D7316_RS22215	COG0183	Belongs to the thiolase family
D7316_RS22220	COG2124	cytochrome p450
D7316_RS22240	COG0183	Belongs to the thiolase family
D7316_RS22250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS22270	COG1024	Enoyl-CoA hydratase
D7316_RS22280	COG2070	2-Nitropropane dioxygenase
D7316_RS22285	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS22290	COG1960	acyl-CoA dehydrogenase activity
D7316_RS22295	COG1960	acyl-CoA dehydrogenase activity
D7316_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS22315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS22365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7316_RS22385	COG1194	a g-specific adenine glycosylase
D7316_RS22405	COG1960	acyl-CoA dehydrogenase activity
D7316_RS22425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D7316_RS22435	COG1329	Transcriptional regulator
D7316_RS22440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D7316_RS22445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D7316_RS22455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7316_RS22465	COG2272	Belongs to the type-B carboxylesterase lipase family
D7316_RS22470	COG0596	Alpha beta hydrolase
D7316_RS22505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7316_RS22510	COG1120	ATPase activity
D7316_RS22515	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7316_RS22530	COG0438	transferase activity, transferring glycosyl groups
D7316_RS22545	COG1113	amino acid transport
D7316_RS22550	COG0588	phosphoglycerate mutase activity
D7316_RS22560	COG5002	protein histidine kinase activity
D7316_RS22595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7316_RS22620	COG1063	alcohol dehydrogenase
D7316_RS22635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D7316_RS22645	COG0181	hydroxymethylbilane synthase activity
D7316_RS22680	COG1960	acyl-CoA dehydrogenase activity
D7316_RS22685	COG1396	sequence-specific DNA binding
D7316_RS22705	COG1953	Uracil, thiamine, allantoin
D7316_RS22715	COG1309	transcriptional regulator
D7316_RS22725	COG0747	negative chemotaxis
D7316_RS22735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS22750	COG2957	Belongs to the agmatine deiminase family
D7316_RS22755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7316_RS22775	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS22790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D7316_RS22795	COG0406	alpha-ribazole phosphatase activity
D7316_RS22800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7316_RS22805	COG0785	Cytochrome C biogenesis protein
D7316_RS22815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7316_RS22845	COG1136	(ABC) transporter
D7316_RS22920	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS22930	COG2072	flavoprotein involved in K transport
D7316_RS22945	COG2755	lipolytic protein G-D-S-L family
D7316_RS22970	COG0640	Transcriptional regulator
D7316_RS22980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7316_RS22985	COG0798	PFAM Bile acid sodium symporter
D7316_RS22990	COG0640	Transcriptional regulator
D7316_RS22995	COG2188	Transcriptional regulator
D7316_RS23005	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D7316_RS23010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D7316_RS23015	COG3639	organic phosphonate transmembrane transporter activity
D7316_RS23020	COG1063	alcohol dehydrogenase
D7316_RS23050	COG0583	DNA-binding transcription factor activity
D7316_RS23055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7316_RS23060	COG0748	coenzyme F420 binding
D7316_RS23080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7316_RS23090	COG4106	trans-aconitate 2-methyltransferase activity
D7316_RS23095	COG0601	transmembrane transport
D7316_RS23100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7316_RS23105	COG1124	(ABC) transporter
D7316_RS23115	COG1309	transcriptional regulator
D7316_RS23135	COG1660	Displays ATPase and GTPase activities
D7316_RS23160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D7316_RS23165	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D7316_RS23170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7316_RS23185	COG0297	glycogen (starch) synthase activity
D7316_RS23210	COG0489	protein tyrosine kinase activity
D7316_RS23225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7316_RS23245	COG0659	secondary active sulfate transmembrane transporter activity
D7316_RS23250	COG0789	Transcriptional regulator
D7316_RS23265	COG3707	response regulator
D7316_RS23325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS23365	COG0438	transferase activity, transferring glycosyl groups
D7316_RS23385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7316_RS23390	COG5002	protein histidine kinase activity
D7316_RS23390	COG5001	Diguanylate cyclase
D7316_RS23395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7316_RS23405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D7316_RS23415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7316_RS23420	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D7316_RS23445	COG3268	Saccharopine dehydrogenase
D7316_RS23450	COG3180	Ammonia monooxygenase
D7316_RS23455	COG2226	methyltransferase
D7316_RS23460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D7316_RS23485	COG2226	methyltransferase
D7316_RS23490	COG0644	oxidoreductase
D7316_RS23495	COG0142	geranyltranstransferase activity
D7316_RS23500	COG0501	Belongs to the peptidase M48B family
D7316_RS23505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7316_RS23515	COG1666	GTP binding
D7316_RS23535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7316_RS23550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7316_RS23575	COG0081	regulation of translation
D7316_RS23595	COG0346	lactoylglutathione lyase activity
D7316_RS23635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7316_RS23650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS23655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7316_RS23700	COG0085	RNA polymerase activity
D7316_RS23715	COG0477	Major facilitator Superfamily
D7316_RS23735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7316_RS23765	COG0697	spore germination
D7316_RS23870	COG0438	transferase activity, transferring glycosyl groups
D7316_RS23875	COG2226	methyltransferase
D7316_RS23890	COG1309	transcriptional regulator
D7316_RS23905	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS23930	COG0765	amino acid transport
D7316_RS23935	COG1126	abc transporter atp-binding protein
D7316_RS24000	COG4221	oxidoreductase activity
D7316_RS24005	COG2124	cytochrome p450
D7316_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS24030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7316_RS24040	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS24070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7316_RS24110	COG1012	belongs to the aldehyde dehydrogenase family
D7316_RS24115	COG3284	Transcriptional regulator
D7316_RS24140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7316_RS24145	COG0049	tRNA binding
D7316_RS24180	COG2267	carboxylic ester hydrolase activity
D7316_RS24205	COG0300	oxidoreductase activity
D7316_RS24215	COG0531	amino acid
D7316_RS24270	COG0535	radical SAM domain protein
D7316_RS24290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS24305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D7316_RS24315	COG2186	Transcriptional regulator
D7316_RS24320	COG2807	transmembrane transport
D7316_RS24335	COG1953	Uracil, thiamine, allantoin
D7316_RS24340	COG3619	membrane
D7316_RS24355	COG0367	asparagine synthase
D7316_RS24370	COG0051	transcription antitermination factor activity, RNA binding
D7316_RS24380	COG0088	Forms part of the polypeptide exit tunnel
D7316_RS24385	COG0089	rRNA binding
D7316_RS24390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7316_RS24395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7316_RS24400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7316_RS24420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7316_RS24465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS24475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS24505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7316_RS24535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS24570	COG1595	DNA-templated transcription, initiation
D7316_RS24605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7316_RS24615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7316_RS24620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7316_RS24630	COG3961	Belongs to the TPP enzyme family
D7316_RS24645	COG2852	Protein conserved in bacteria
D7316_RS24665	COG1140	nitrate reductase beta subunit
D7316_RS24680	COG2133	pyrroloquinoline quinone binding
D7316_RS24695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7316_RS24705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D7316_RS24710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7316_RS24720	COG0200	Binds to the 23S rRNA
D7316_RS24730	COG0563	adenylate kinase activity
D7316_RS24740	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7316_RS24745	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D7316_RS24750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7316_RS24755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D7316_RS24760	COG1490	D-aminoacyl-tRNA deacylase activity
D7316_RS24770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS24775	COG1116	anion transmembrane transporter activity
D7316_RS24780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7316_RS24795	COG1950	PFAM Membrane protein of
D7316_RS24815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7316_RS24820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7316_RS24830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7316_RS24835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7316_RS24840	COG0202	RNA polymerase activity
D7316_RS24860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7316_RS24865	COG0477	Major facilitator Superfamily
D7316_RS24870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D7316_RS24870	COG1082	Xylose isomerase domain protein TIM barrel
D7316_RS24895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7316_RS24945	COG0531	amino acid
D7316_RS24985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D7316_RS24990	COG0653	protein targeting
D7316_RS25000	COG1063	alcohol dehydrogenase
D7316_RS25035	COG2814	Major facilitator Superfamily
D7316_RS25040	COG0583	DNA-binding transcription factor activity
D7316_RS25050	COG0673	inositol 2-dehydrogenase activity
D7316_RS25055	COG1609	Transcriptional regulator
D7316_RS25060	COG2814	Major facilitator Superfamily
D7316_RS25065	COG0673	inositol 2-dehydrogenase activity
D7316_RS25075	COG0673	inositol 2-dehydrogenase activity
D7316_RS25080	COG3962	Belongs to the TPP enzyme family
D7316_RS25085	COG3718	enzyme involved in inositol metabolism
D7316_RS25100	COG0673	inositol 2-dehydrogenase activity
D7316_RS25110	COG1879	ABC-type sugar transport system periplasmic component
D7316_RS25115	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7316_RS25125	COG1609	Transcriptional regulator
D7316_RS25140	COG1082	Xylose isomerase domain protein TIM barrel
D7316_RS25145	COG0673	inositol 2-dehydrogenase activity
D7316_RS25150	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS25160	COG1609	Transcriptional regulator
D7316_RS25165	COG2188	Transcriptional regulator
D7316_RS25175	COG1162	GTPase activity
D7316_RS25180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7316_RS25220	COG1063	alcohol dehydrogenase
D7316_RS25230	COG3402	PFAM membrane-flanked domain
D7316_RS25240	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS25245	COG1960	acyl-CoA dehydrogenase activity
D7316_RS25275	COG0235	Class ii aldolase
D7316_RS25285	COG3284	Transcriptional regulator
D7316_RS25290	COG0459	protein refolding
D7316_RS25295	COG1063	alcohol dehydrogenase
D7316_RS25340	COG0436	Aminotransferase
D7316_RS25345	COG0656	L-ascorbic acid biosynthetic process
D7316_RS25355	COG0640	Transcriptional regulator
D7316_RS25385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D7316_RS25425	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7316_RS25430	COG2814	Major facilitator Superfamily
D7316_RS25435	COG1846	Transcriptional regulator
D7316_RS25460	COG1335	isochorismatase
D7316_RS25495	COG2135	peptidase activity
D7316_RS25500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7316_RS25505	COG1595	DNA-templated transcription, initiation
D7316_RS25515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D7316_RS25535	COG1597	lipid kinase activity
D7316_RS25545	COG1192	Involved in chromosome partitioning
D7316_RS25555	COG0513	Belongs to the DEAD box helicase family
D7316_RS25570	COG1309	transcriptional regulator
D7316_RS25600	COG2223	nitrite transmembrane transporter activity
D7316_RS25605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7316_RS25605	COG2146	nitrite reductase [NAD(P)H] activity
D7316_RS25625	COG3695	enzyme binding
D7316_RS25640	COG0210	DNA helicase
D7316_RS25675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D7316_RS25690	COG3480	Lon protease (S16) C-terminal proteolytic domain
D7316_RS25700	COG1615	UPF0182 protein
D7316_RS25760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7316_RS25765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7316_RS25770	COG1960	acyl-CoA dehydrogenase activity
D7316_RS25775	COG1960	acyl-CoA dehydrogenase activity
D7316_RS25805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D7316_RS25810	COG0668	transmembrane transport
D7316_RS25820	COG2884	Cell division ATP-binding protein ftsE
D7316_RS25825	COG2177	Part of the ABC transporter FtsEX involved in
D7316_RS25830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D7316_RS25835	COG3345	alpha-galactosidase
D7316_RS25840	COG2365	Tyrosine phosphatase family
D7316_RS25860	COG0076	glutamate decarboxylase activity
D7316_RS25890	COG1131	(ABC) transporter
D7316_RS25900	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS25910	COG0033	Phosphoglucomutase
D7316_RS25925	COG1028	Short-chain dehydrogenase reductase Sdr
D7316_RS25940	COG1752	Esterase of the alpha-beta hydrolase superfamily
D7316_RS25985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7316_RS25995	COG1322	Protein conserved in bacteria
D7316_RS26000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7316_RS26000	COG2169	Transcriptional regulator
D7316_RS26020	COG0012	GTP binding
D7316_RS26025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7316_RS26025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7316_RS26030	COG0488	(ABC) transporter
D7316_RS26055	COG1946	Acyl-CoA thioesterase
D7316_RS26085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D7316_RS26095	COG4106	trans-aconitate 2-methyltransferase activity
D7316_RS26110	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D7316_RS26150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7316_RS26175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D7316_RS26175	COG1796	DNA polymerase
D7316_RS26185	COG1131	(ABC) transporter
D7316_RS26190	COG4585	Histidine kinase
D7316_RS26195	COG2197	response regulator
D7316_RS26205	COG2076	Multidrug Resistance protein
D7316_RS26210	COG1607	acyl-coa hydrolase
D7316_RS26220	COG0475	glutathione-regulated potassium exporter activity
D7316_RS26225	COG1388	LysM domain
D7316_RS26240	COG1966	Carbon starvation protein
D7316_RS26265	COG3629	intracellular signal transduction
D7316_RS26275	COG1960	acyl-CoA dehydrogenase activity
D7316_RS26280	COG1960	acyl-CoA dehydrogenase activity
D7316_RS26290	COG0628	permease
D7316_RS26295	COG1024	Enoyl-CoA hydratase
D7316_RS26315	COG1595	DNA-templated transcription, initiation
D7316_RS26370	COG0477	Major facilitator Superfamily
D7316_RS26405	COG3842	ATPase activity
D7316_RS26420	COG1217	gtp-binding protein TYPA
D7316_RS26425	COG0747	negative chemotaxis
D7316_RS26430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7316_RS26440	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D7316_RS26445	COG2072	flavoprotein involved in K transport
D7316_RS26450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D7316_RS26510	COG1611	Belongs to the LOG family
D7316_RS26515	COG1611	Belongs to the LOG family
D7316_RS26520	COG0318	PFAM AMP-dependent synthetase and ligase
D7316_RS26525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7316_RS26530	COG0463	Glycosyl transferase, family 2
D7316_RS26545	COG2226	methyltransferase
D7316_RS26550	COG0297	glycogen (starch) synthase activity
D7316_RS26555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D7316_RS26595	COG1482	cell wall glycoprotein biosynthetic process
D7316_RS26610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7316_RS26650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7316_RS26660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D7316_RS26695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7316_RS26700	COG1119	ATPase activity
D7316_RS26715	COG1024	Enoyl-CoA hydratase
D7316_RS26720	COG2226	methyltransferase
D7316_RS26730	COG2814	Major facilitator Superfamily
D7316_RS26735	COG4977	sequence-specific DNA binding
D7316_RS26745	COG0110	maltose O-acetyltransferase activity
D7316_RS26765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D7316_RS26810	COG0482	sulfurtransferase activity
D7316_RS26825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7316_RS26840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7316_RS26860	COG4585	Histidine kinase
D7316_RS26865	COG2197	response regulator
D7316_RS26880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7316_RS26905	COG0129	dihydroxy-acid dehydratase activity
D7316_RS26910	COG2239	Acts as a magnesium transporter
D7316_RS26925	COG0440	acetolactate synthase activity
D7316_RS26945	COG0473	3-isopropylmalate dehydrogenase activity
D7316_RS26950	COG2271	Major facilitator Superfamily
D7316_RS26955	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7316_RS26965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7316_RS26995	COG2161	toxin-antitoxin pair type II binding