locus-tag class description HUN08_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUN08_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUN08_RS00020 ENOG4105K7N UPF0232 protein HUN08_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUN08_RS00065 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) HUN08_RS00070 ENOG4107ZXI Rhomboid family HUN08_RS00100 ENOG4107TPY serine threonine protein kinase HUN08_RS00105 ENOG4105CJN penicillin-binding protein HUN08_RS00120 ENOG4105HZM Fha domain containing protein HUN08_RS00125 ENOG4105TV9 FHA Domain-Containing protein HUN08_RS00135 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUN08_RS00145 ENOG4106MP8 UPF0754 membrane protein HUN08_RS00160 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HUN08_RS00180 ENOG4105EMU Dehydrogenase HUN08_RS00205 ENOG4107QNK )-transporter HUN08_RS00210 ENOG4105CE4 GlcNAc 6-P deacetylase HUN08_RS00215 ENOG4105CSH Transporter HUN08_RS00225 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUN08_RS00245 ENOG4108V0P LemA family HUN08_RS00265 ENOG4105CBC glutamate synthase HUN08_RS00275 ENOG4105FFC UPF0187 protein HUN08_RS00295 ENOG410848D S4 domain protein YaaA HUN08_RS00300 ENOG4105CRK lysyL-tRNA synthetase HUN08_RS00330 ENOG4108KPJ rna polymerase sigma factor HUN08_RS00345 ENOG4105PMW Domain of unknown function (DUF1990) HUN08_RS00385 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUN08_RS00415 ENOG41085GJ domain protein HUN08_RS00440 ENOG4108KGH TRANSCRIPTIONal HUN08_RS00470 ENOG41083TI Protein CrcB homolog HUN08_RS00475 ENOG4107JBM CrcB-like protein HUN08_RS00480 ENOG4105CQC Prephenate dehydratase HUN08_RS00500 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUN08_RS00555 ENOG4105F6E Acyl-transferase HUN08_RS00565 ENOG4105PSQ Acyl-transferase HUN08_RS00575 ENOG4105JFG SpoIID LytB domain protein HUN08_RS00595 ENOG410602S Transferase HUN08_RS00605 ENOG4106YN8 Prenyltransferase HUN08_RS00610 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids HUN08_RS00640 ENOG4107RCI amp-dependent synthetase and ligase HUN08_RS00645 ENOG4107EEY synthase HUN08_RS00650 ENOG4105D8K carboxyl transferase HUN08_RS00665 ENOG4105J1Z Arabinosyltransferase HUN08_RS00675 ENOG4105J1Z Arabinosyltransferase HUN08_RS00680 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUN08_RS00685 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases HUN08_RS00690 ENOG4108RG3 short-chain dehydrogenase reductase HUN08_RS00695 ENOG4105IQ5 FAD linked oxidase domain protein HUN08_RS00710 ENOG4105E9Q Acyl-transferase HUN08_RS00735 ENOG4108MKI Glycosyl transferase, family 2 HUN08_RS00775 ENOG4108JA1 polyketide synthase HUN08_RS00785 ENOG4105KPY Small multidrug resistance protein HUN08_RS00825 ENOG4107RCI amp-dependent synthetase and ligase HUN08_RS00830 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUN08_RS00860 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUN08_RS00875 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS00885 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta HUN08_RS00890 ENOG4105K5B UPF0225 protein HUN08_RS00925 ENOG4105NI8 Cytosine-specific methyltransferase HUN08_RS00970 ENOG4105C26 Dehydrogenase HUN08_RS00975 ENOG4107RR1 TRANSCRIPTIONal HUN08_RS01005 ENOG4105EYF MMPL domain protein HUN08_RS01020 ENOG4105NRA 50s ribosomal protein l31 type b HUN08_RS01030 ENOG4105KDC 50s ribosomal protein l28 HUN08_RS01040 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUN08_RS01045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUN08_RS01090 ENOG4105CIH Imidazole acetol-phosphate transaminase HUN08_RS01145 ENOG4105EVN Prephenate dehydrogenase HUN08_RS01155 ENOG4108Z6B deaminase HUN08_RS01175 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUN08_RS01190 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUN08_RS01195 ENOG4105DF2 NADH dehydrogenase subunit j HUN08_RS01205 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUN08_RS01210 ENOG4108IEH NADH dehydrogenase subunit g HUN08_RS01215 ENOG4107QIZ NADH dehydrogenase HUN08_RS01225 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUN08_RS01230 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUN08_RS01250 ENOG4105CPF Cell wall formation (By similarity) HUN08_RS01270 ENOG4107TXC Transcriptional regulator HUN08_RS01280 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HUN08_RS01285 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HUN08_RS01295 ENOG4105GN4 DNA ligase HUN08_RS01320 ENOG4105DFH Transport of potassium into the cell (By similarity) HUN08_RS01350 ENOG4105XT2 Transcriptional regulator HUN08_RS01355 ENOG4108VJY integral membrane protein HUN08_RS01370 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUN08_RS01385 ENOG4105C34 Pseudouridine synthase HUN08_RS01420 ENOG4105F1K Glutamine amidotransferase HUN08_RS01425 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUN08_RS01440 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUN08_RS01460 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUN08_RS01510 ENOG4105C57 major facilitator superfamily HUN08_RS01520 ENOG4105CFH Aspartokinase HUN08_RS01545 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 HUN08_RS01565 ENOG4108ZHJ Organic hydroperoxide resistance protein HUN08_RS01585 ENOG4107RGJ metallophosphoesterase HUN08_RS01590 ENOG4105BZ4 penicillin-binding protein HUN08_RS01595 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUN08_RS01600 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUN08_RS01640 ENOG4105K63 Thioredoxin HUN08_RS01645 ENOG4105P8F nudix hydrolase HUN08_RS01655 ENOG4105D74 hydrolase HUN08_RS01665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUN08_RS01690 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS01740 ENOG4105EUB pirin domain protein HUN08_RS01745 ENOG4108I5C dEAD DEAH box helicase HUN08_RS01750 ENOG4105VEQ Cold shock protein HUN08_RS01760 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUN08_RS01785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUN08_RS01795 ENOG4107QRG dna polymerase iii HUN08_RS01800 ENOG4105EYW Ion transport protein HUN08_RS01895 ENOG4105CMR udp-glucose 4-epimerase HUN08_RS01900 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUN08_RS01905 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HUN08_RS01910 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUN08_RS01950 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS01955 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUN08_RS01960 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUN08_RS01970 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUN08_RS01975 ENOG4105GRZ Ycii-related protein HUN08_RS01980 ENOG4105CHP RNA polymerase HUN08_RS01990 ENOG4105CT1 (ABC) transporter HUN08_RS02025 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUN08_RS02040 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUN08_RS02045 ENOG4105CSH Transporter HUN08_RS02050 ENOG4105DWF phosphomethylpyrimidine kinase HUN08_RS02055 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUN08_RS02085 ENOG4105F95 Monooxygenase HUN08_RS02090 ENOG4105CHR reductase HUN08_RS02095 ENOG4107RN6 Monooxygenase HUN08_RS02110 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUN08_RS02115 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUN08_RS02130 ENOG41064MX Tetr family transcriptional regulator HUN08_RS02150 ENOG4105PDP Short chain dehydrogenase HUN08_RS02190 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUN08_RS02205 ENOG41080TA Multiple resistance and ph regulation protein f HUN08_RS02215 ENOG4108JPZ Monovalent cation H antiporter subunit D HUN08_RS02220 ENOG4105MKQ Monovalent cation H antiporter subunit C HUN08_RS02225 ENOG4105D65 subunit l HUN08_RS02235 ENOG4105XTG Pfam:DUF156 HUN08_RS02250 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUN08_RS02260 ENOG4105P3N Membrane HUN08_RS02265 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS02270 ENOG4105CC9 acyl-Coa dehydrogenase HUN08_RS02290 ENOG4105CS2 ec 3.2.1.21 HUN08_RS02400 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUN08_RS02415 ENOG4105DA5 (ABC) transporter HUN08_RS02435 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUN08_RS02480 ENOG4107RPH Isocitrate lyase HUN08_RS02490 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUN08_RS02495 ENOG4105CSR polyphosphate kinase 2 HUN08_RS02500 ENOG4105CHR reductase HUN08_RS02505 ENOG4106BRA Membrane HUN08_RS02535 ENOG4107R4N Cell wall formation (By similarity) HUN08_RS02560 ENOG4105CIY formyltetrahydrofolate deformylase HUN08_RS02565 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUN08_RS02595 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUN08_RS02610 ENOG4105E6M Sulphatase-modifying factor protein HUN08_RS02620 ENOG41061ZR Transcriptional regulator HUN08_RS02620 ENOG41061ZR Transcriptional regulator HUN08_RS02625 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUN08_RS02650 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUN08_RS02655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUN08_RS02660 ENOG4105BZU Histidine kinase HUN08_RS02675 ENOG4105C9U ATP-dependent DNA helicase RecQ HUN08_RS02710 ENOG4105CSU acyl-Coa dehydrogenase HUN08_RS02725 ENOG4105C83 adenylosuccinate lyase HUN08_RS02735 ENOG4105C8V SAICAR synthetase HUN08_RS02760 ENOG410900P UPF0336 protein HUN08_RS02765 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUN08_RS02775 ENOG4108V06 Glutathione peroxidase HUN08_RS02780 ENOG410839H phosphoribosylformylglycinamidine synthase HUN08_RS02785 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUN08_RS02790 ENOG4105DFM M18 family aminopeptidase HUN08_RS02830 ENOG4108SGK Tetr family transcriptional regulator HUN08_RS02835 ENOG4105D2B acyl-CoA dehydrogenase HUN08_RS02845 ENOG4105X7H acyl-CoA dehydrogenase HUN08_RS02850 ENOG410900P UPF0336 protein HUN08_RS02855 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS02875 ENOG4105C57 major facilitator superfamily HUN08_RS02895 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUN08_RS02900 ENOG4105IKQ hydratase HUN08_RS02905 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUN08_RS02910 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUN08_RS02995 ENOG4108KC1 acyl-Coa dehydrogenase HUN08_RS03000 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase HUN08_RS03005 ENOG4105MXW flavin reductase domain protein, FMN-binding HUN08_RS03015 ENOG4105CHR reductase HUN08_RS03025 ENOG4105D2B acyl-CoA dehydrogenase HUN08_RS03030 ENOG4105D2B acyl-CoA dehydrogenase HUN08_RS03035 ENOG4105CC9 acyl-Coa dehydrogenase HUN08_RS03055 ENOG4108Z4U Ferredoxin HUN08_RS03070 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HUN08_RS03080 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo HUN08_RS03150 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUN08_RS03195 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUN08_RS03205 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUN08_RS03220 ENOG4105C4M (Ubiquinol oxidase) subunit I HUN08_RS03225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUN08_RS03230 ENOG4108JJ9 ABC, transporter HUN08_RS03235 ENOG4108JJ8 (ABC) transporter HUN08_RS03245 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands HUN08_RS03265 ENOG4105E39 Enoyl-CoA hydratase HUN08_RS03270 ENOG4105PKJ carbohydrate binding HUN08_RS03275 ENOG4105KHC sulfurtransferase HUN08_RS03285 ENOG4107NHD transcriptional regulator HUN08_RS03290 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUN08_RS03305 ENOG4108RCF TRANSCRIPTIONal HUN08_RS03415 ENOG4107ZR7 Membrane HUN08_RS03440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUN08_RS03445 ENOG4108YYC ycei family HUN08_RS03525 ENOG4105VEQ Cold shock protein HUN08_RS03535 ENOG4108N0W Major Facilitator superfamily HUN08_RS03550 ENOG410841Q phosphoesterase PA-phosphatase related protein HUN08_RS03565 ENOG4105C7N Xanthine uracil vitamin C permease HUN08_RS03575 ENOG4105FCS tRNA rRNA methyltransferase HUN08_RS03595 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS03615 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUN08_RS03620 ENOG4108X07 Tetr family transcriptional regulator HUN08_RS03625 ENOG4105CIG ABC transporter HUN08_RS03635 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUN08_RS03655 ENOG4107SFI Major Facilitator superfamily HUN08_RS03675 ENOG4107R7A Allophanate hydrolase subunit 2 HUN08_RS03680 ENOG4105P4J Allophanate hydrolase, subunit 1 HUN08_RS03690 ENOG41081K0 peptidylprolyl cis-trans isomerase HUN08_RS03720 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUN08_RS03725 ENOG4108VX5 3-methyladenine DNA glycosylase HUN08_RS03750 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo HUN08_RS03770 ENOG4107QP8 phosphohexose isomerase HUN08_RS03790 ENOG4108FN7 Aldo keto reductase HUN08_RS03795 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUN08_RS03810 ENOG41063SB peptidase HUN08_RS03815 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUN08_RS03845 ENOG4107QX3 carboxylase HUN08_RS03855 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS03880 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS03895 ENOG4107R7A Allophanate hydrolase subunit 2 HUN08_RS03945 ENOG4105EET magnesium chelatase HUN08_RS03970 ENOG4105V9V Short-chain dehydrogenase reductase Sdr HUN08_RS04015 ENOG4105BZ1 (ABC) transporter HUN08_RS04035 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUN08_RS04040 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUN08_RS04050 ENOG4105D9U N-acetyltransferase HUN08_RS04060 ENOG4107QWP ABC-2 type transporter HUN08_RS04065 ENOG4105CJ1 ABC, transporter HUN08_RS04115 ENOG4105EDW glycosyl transferase, family 39 HUN08_RS04130 ENOG4105CRK lysyL-tRNA synthetase HUN08_RS04135 ENOG4105BZU Histidine kinase HUN08_RS04140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUN08_RS04145 ENOG4105C1J atp-dependent rna helicase HUN08_RS04150 ENOG4105EBR Carboxylesterase HUN08_RS04170 ENOG4108YV4 Universal stress protein HUN08_RS04175 ENOG4105C94 Transporter HUN08_RS04195 ENOG4105CRQ synthase (Component I) HUN08_RS04230 ENOG4105JAB phenazine biosynthesis protein, phzf family HUN08_RS04235 ENOG4105F8V Hydrolase, tatD family HUN08_RS04240 ENOG4106839 domain protein HUN08_RS04245 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUN08_RS04250 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUN08_RS04260 ENOG4105C5H ABC transporter HUN08_RS04320 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUN08_RS04345 ENOG4105CHR reductase HUN08_RS04355 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS04380 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUN08_RS04385 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUN08_RS04390 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUN08_RS04420 ENOG4105DA5 (ABC) transporter HUN08_RS04430 ENOG4105MXB limonene-12-epoxide hydrolase HUN08_RS04485 ENOG41067SE Tetr family transcriptional regulator HUN08_RS04510 ENOG4108Z7F N-acetyltransferase HUN08_RS04530 ENOG4105DBE peroxidase HUN08_RS04535 ENOG410650H (LipO)protein HUN08_RS04550 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUN08_RS04600 ENOG4105EJ2 Transcriptional regulator HUN08_RS04640 ENOG4105E5G Alpha beta hydrolase fold HUN08_RS04650 ENOG4105ETX regulatoR HUN08_RS04655 ENOG41062D9 Histidine kinase HUN08_RS04665 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUN08_RS04675 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HUN08_RS04690 ENOG4105CHR reductase HUN08_RS04695 ENOG4105CSU acyl-Coa dehydrogenase HUN08_RS04700 ENOG4107ZXU DSBA oxidoreductase HUN08_RS04710 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HUN08_RS04740 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUN08_RS04755 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUN08_RS04780 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS04800 ENOG4107ZQN disulfide bond HUN08_RS04845 ENOG4105E39 Enoyl-CoA hydratase HUN08_RS04860 ENOG4105EUB pirin domain protein HUN08_RS04905 ENOG4107R13 MMPL domain protein HUN08_RS04920 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS04950 ENOG4105CI2 imidazolone-5-propionate hydrolase HUN08_RS04955 ENOG4108RZE Tetr family transcriptional regulator HUN08_RS04960 ENOG4105EYF MMPL domain protein HUN08_RS04985 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUN08_RS05010 ENOG4105C7Z Conserved Protein HUN08_RS05025 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUN08_RS05045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUN08_RS05060 ENOG4105CS9 pantothenic acid kinase HUN08_RS05070 ENOG4105C57 major facilitator superfamily HUN08_RS05080 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUN08_RS05090 ENOG4108IAB Phoh family HUN08_RS05125 ENOG4107GFK fumarate HUN08_RS05130 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS05160 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUN08_RS05165 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUN08_RS05175 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUN08_RS05190 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUN08_RS05200 ENOG4105EC2 ftsk spoIIIe HUN08_RS05210 ENOG4105E6M Sulphatase-modifying factor protein HUN08_RS05220 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUN08_RS05225 ENOG4108UJD 30S ribosomal protein S9 HUN08_RS05230 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUN08_RS05265 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUN08_RS05280 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUN08_RS05305 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUN08_RS05310 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUN08_RS05315 ENOG4105WQI isochorismatase HUN08_RS05325 ENOG4105C0W non-ribosomal peptide synthetase HUN08_RS05330 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUN08_RS05335 ENOG4105DQ5 transport system permease protein HUN08_RS05340 ENOG4105TVJ transport system, permease HUN08_RS05345 ENOG4105E0A ABC, transporter HUN08_RS05350 ENOG4107RM1 amidohydrolase HUN08_RS05365 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUN08_RS05385 ENOG4108VT4 HUN08_RS05395 ENOG4107QVP Dehydrogenase HUN08_RS05425 ENOG4105UEI Transcriptional Regulator AraC Family HUN08_RS05440 ENOG4108YYH Nadph-dependent fmn reductase HUN08_RS05445 ENOG4105D9P serine threonine protein kinase HUN08_RS05490 ENOG4105C0B DNA polymerase III (alpha subunit) HUN08_RS05505 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUN08_RS05510 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUN08_RS05525 ENOG4108IQK o-acetylhomoserine HUN08_RS05555 ENOG4105C31 Tryptophanyl-tRNA synthetase HUN08_RS05560 ENOG4107H3J ribonuclease HUN08_RS05585 ENOG4105E33 succinate dehydrogenase HUN08_RS05625 ENOG4105K4H Nlp p60 protein HUN08_RS05640 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUN08_RS05700 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUN08_RS05705 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUN08_RS05715 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUN08_RS05730 ENOG4107QRT dEAD DEAH box helicase HUN08_RS05775 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS05780 ENOG4105CT3 Monooxygenase HUN08_RS05785 ENOG4105G9B Transcriptional regulator HUN08_RS05800 ENOG4105CFF transcriptional regulator HUN08_RS05810 ENOG4105CR4 methylisocitrate lyase HUN08_RS05900 ENOG4108JIK carboxylase HUN08_RS05920 ENOG4107WR6 Maf-like protein HUN08_RS05930 ENOG4105D8K carboxyl transferase HUN08_RS05935 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HUN08_RS05950 ENOG4105ETX regulatoR HUN08_RS05955 ENOG410804D Sensor Signal Transduction Histidine Kinase HUN08_RS06030 ENOG4107TB5 TRANSCRIPTIONal HUN08_RS06045 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUN08_RS06050 ENOG4107ZBN O-methyltransferase HUN08_RS06055 ENOG4105DU6 RNA polymerase HUN08_RS06060 ENOG4106684 HUN08_RS06065 ENOG4105C0H protease HUN08_RS06070 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUN08_RS06090 ENOG4105CJW magnesium transporter HUN08_RS06140 ENOG4105D7N magnesium and cobalt transport protein CorA HUN08_RS06175 ENOG4105CHF Glutathione S-transferase HUN08_RS06230 ENOG4105C75 arginyL-tRNA synthetase HUN08_RS06235 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUN08_RS06240 ENOG4105D6E homoserine dehydrogenase HUN08_RS06245 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUN08_RS06250 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUN08_RS06265 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUN08_RS06270 ENOG4105VFB Binds the 23S rRNA (By similarity) HUN08_RS06275 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUN08_RS06280 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUN08_RS06290 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUN08_RS06305 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HUN08_RS06310 ENOG4105ZA1 atp synthase HUN08_RS06315 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUN08_RS06320 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUN08_RS06325 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUN08_RS06330 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUN08_RS06335 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUN08_RS06340 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUN08_RS06355 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUN08_RS06380 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUN08_RS06395 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS06400 ENOG4105EYF MMPL domain protein HUN08_RS06410 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUN08_RS06420 ENOG4107RKP Nicotinate phosphoribosyltransferase HUN08_RS06425 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUN08_RS06435 ENOG4105KXX peptidase s58 dmpa HUN08_RS06455 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUN08_RS06465 ENOG4108RQ5 Beta-lactamase domain-containing protein HUN08_RS06470 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUN08_RS06475 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUN08_RS06510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUN08_RS06540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUN08_RS06565 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUN08_RS06575 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUN08_RS06580 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS06610 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUN08_RS06615 ENOG4108JPW Aminotransferase HUN08_RS06620 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUN08_RS06640 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUN08_RS06645 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUN08_RS06650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUN08_RS06655 ENOG4105U3E Transcriptional regulator HUN08_RS06685 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUN08_RS06690 ENOG4105E2Y ABC, transporter HUN08_RS06700 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUN08_RS06710 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUN08_RS06730 ENOG4107QND Nitrite extrusion protein HUN08_RS06755 ENOG4107QZF nitrite reductase NADPH large subunit HUN08_RS06760 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUN08_RS06765 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUN08_RS06770 ENOG4105ENX hydrolase HUN08_RS06790 ENOG4105EUZ Beta-lactamase domain protein HUN08_RS06800 ENOG4105C7I Dehydrogenase HUN08_RS06815 ENOG4107R3N Filamentation induced by cAMP protein fic HUN08_RS06820 ENOG4105CG3 alpha amylase, catalytic region HUN08_RS06840 ENOG4105J5T Amp-dependent synthetase and ligase HUN08_RS06850 ENOG4105H3G oxidoreductase HUN08_RS06865 ENOG4108ZM9 phosphoglycerate mutase HUN08_RS06900 ENOG4109057 HUN08_RS06915 ENOG4107QJT sodium dicarboxylate symporter HUN08_RS06935 ENOG4105MC2 DSBA oxidoreductase HUN08_RS07125 ENOG4108T50 Protein of unknown function (DUF690) HUN08_RS07130 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUN08_RS07140 ENOG4105EC2 ftsk spoIIIe HUN08_RS07145 ENOG4106F1P AAA ATPase, central domain protein HUN08_RS07150 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUN08_RS07165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUN08_RS07175 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUN08_RS07180 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUN08_RS07190 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUN08_RS07195 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUN08_RS07210 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUN08_RS07215 ENOG4105C03 ribonuclease HUN08_RS07215 ENOG4105C03 ribonuclease HUN08_RS07220 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUN08_RS07225 ENOG4105K46 50S ribosomal protein l27 HUN08_RS07230 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUN08_RS07235 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUN08_RS07240 ENOG4106H78 methyltransferase HUN08_RS07265 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUN08_RS07270 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUN08_RS07295 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUN08_RS07300 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUN08_RS07315 ENOG4107TXC Transcriptional regulator HUN08_RS07330 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUN08_RS07345 ENOG4105K5M 30s ribosomal protein S16 HUN08_RS07355 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUN08_RS07360 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUN08_RS07365 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUN08_RS07375 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUN08_RS07390 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HUN08_RS07395 ENOG4108RH7 phosphoglycerate mutase HUN08_RS07435 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUN08_RS07450 ENOG4105CE9 30S ribosomal protein S2 HUN08_RS07455 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUN08_RS07460 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUN08_RS07465 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUN08_RS07505 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUN08_RS07515 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUN08_RS07520 ENOG4105DZP Membrane-associated zinc metalloprotease HUN08_RS07525 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUN08_RS07540 ENOG4105J5T Amp-dependent synthetase and ligase HUN08_RS07560 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUN08_RS07565 ENOG4105D74 hydrolase HUN08_RS07575 ENOG4105DWT malate dehydrogenase (quinone) HUN08_RS07625 ENOG4107XFJ UPF0246 protein HUN08_RS07630 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUN08_RS07645 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUN08_RS07660 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUN08_RS07670 ENOG4105SFS phosphoesterase RecJ domain protein HUN08_RS07705 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUN08_RS07710 ENOG4105C29 acyl-CoA thioesterase HUN08_RS07770 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS07825 ENOG4105EAB amino acid AbC transporter HUN08_RS07830 ENOG4105E5Q amino acid AbC transporter HUN08_RS07835 ENOG4105CDA abc transporter atp-binding protein HUN08_RS07840 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUN08_RS07845 ENOG410905P Pyridoxamine 5-phosphate HUN08_RS07850 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUN08_RS07855 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUN08_RS07870 ENOG41090A1 ferritin HUN08_RS07875 ENOG4108RWI nicotinamidase HUN08_RS07885 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUN08_RS07905 ENOG4105EEM helicase HUN08_RS07920 ENOG4105C5X domain protein HUN08_RS07950 ENOG41084BS 50S ribosomal protein L35 HUN08_RS07955 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUN08_RS07975 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUN08_RS07980 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUN08_RS07995 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUN08_RS08000 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUN08_RS08005 ENOG4105CAS nag kinase HUN08_RS08015 ENOG4105DBV ornithine carbamoyltransferase HUN08_RS08025 ENOG4105CDH Citrulline--aspartate ligase HUN08_RS08030 ENOG4105CH7 arginosuccinase HUN08_RS08040 ENOG4105W49 UPF0434 protein HUN08_RS08045 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUN08_RS08065 ENOG4105DSU hydrolase HUN08_RS08080 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUN08_RS08110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUN08_RS08135 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUN08_RS08145 ENOG4105CAT Cytidine monophosphate kinase HUN08_RS08150 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUN08_RS08165 ENOG4105EHG Permease protein HUN08_RS08170 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUN08_RS08205 ENOG4107TB5 TRANSCRIPTIONal HUN08_RS08210 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUN08_RS08220 ENOG4105E9K Isocitrate dehydrogenase HUN08_RS08285 ENOG4105MXW flavin reductase domain protein, FMN-binding HUN08_RS08290 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUN08_RS08300 ENOG4107T8P acyl-Coa dehydrogenase HUN08_RS08305 ENOG4105FBW Monooxygenase HUN08_RS08335 ENOG41080RH Thioredoxin HUN08_RS08345 ENOG4105C5H ABC transporter HUN08_RS08360 ENOG4108Q5F Tetr family transcriptional regulator HUN08_RS08365 ENOG4107QM5 aconitate hydratase HUN08_RS08375 ENOG4105ZXU NLP P60 protein HUN08_RS08380 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUN08_RS08390 ENOG4107QVM von Willebrand factor, type A HUN08_RS08400 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUN08_RS08405 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUN08_RS08470 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUN08_RS08510 ENOG4107VEG TrkA-N domain protein HUN08_RS08515 ENOG4105C0X amino acid HUN08_RS08520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUN08_RS08525 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUN08_RS08530 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HUN08_RS08540 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUN08_RS08550 ENOG4107JTW chlorite dismutase HUN08_RS08555 ENOG4105E0X reductase HUN08_RS08560 ENOG4108P2G integral membrane protein HUN08_RS08610 ENOG4105C22 threonyL-tRNA synthetase HUN08_RS08625 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUN08_RS08630 ENOG4105E2K Glycosyl transferase (Group 1 HUN08_RS08640 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUN08_RS08645 ENOG4108ZF3 Phosphatase HUN08_RS08660 ENOG4105C29 acyl-CoA thioesterase HUN08_RS08665 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUN08_RS08670 ENOG4105CDY transcriptional regulatory protein HUN08_RS08675 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUN08_RS08680 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUN08_RS08685 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUN08_RS08700 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUN08_RS08705 ENOG4108NY6 Extracellular solute-binding protein, family 5 HUN08_RS08710 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUN08_RS08715 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUN08_RS08720 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUN08_RS08740 ENOG4105C9M aspartyl-trna synthetase HUN08_RS08755 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUN08_RS08760 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUN08_RS08765 ENOG4105HHA aminodeoxychorismate lyase HUN08_RS08770 ENOG4105E2X shikimate dehydrogenase HUN08_RS08780 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUN08_RS08790 ENOG4105D49 3-dehydroquinate synthase HUN08_RS08800 ENOG4105DC7 peptidase M24 HUN08_RS08805 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUN08_RS08810 ENOG410803B Involved in the transcription termination process (By similarity) HUN08_RS08815 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUN08_RS08820 ENOG4105CXT aspartate transcarbamylase HUN08_RS08835 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUN08_RS08845 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUN08_RS08860 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUN08_RS08865 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUN08_RS08875 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUN08_RS08885 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUN08_RS08915 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUN08_RS08920 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUN08_RS08935 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUN08_RS08950 ENOG4105CIE May be required for sporulation (By similarity) HUN08_RS08955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUN08_RS08960 ENOG4105BZA Phosphoglycerate kinase HUN08_RS08965 ENOG4105CP7 Triose-phosphate isomerase HUN08_RS08975 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUN08_RS08995 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUN08_RS09010 ENOG4105Y3U Transglycosylase-associated protein HUN08_RS09040 ENOG4105DBE peroxidase HUN08_RS09045 ENOG41080T7 secreted protein HUN08_RS09090 ENOG4105D5Q Arginine ornithine antiporter HUN08_RS09115 ENOG4105C26 Dehydrogenase HUN08_RS09140 ENOG4105DZS Phenylacetate-CoA ligase HUN08_RS09145 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUN08_RS09175 ENOG4105DYW oxidoreductase HUN08_RS09190 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUN08_RS09205 ENOG4105DUX Transporter HUN08_RS09220 ENOG4105Q70 HUN08_RS09245 ENOG4105D74 hydrolase HUN08_RS09250 ENOG4105CTK cobaltochelatase, cobn subunit HUN08_RS09290 ENOG4108RG3 short-chain dehydrogenase reductase HUN08_RS09335 ENOG4107QKA exodeoxyribonuclease V beta HUN08_RS09380 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUN08_RS09390 ENOG4105C37 (CBS) domain HUN08_RS09405 ENOG4107QP3 malate synthase g HUN08_RS09435 ENOG4108UW8 fha domain-containing protein HUN08_RS09440 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUN08_RS09450 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUN08_RS09465 ENOG4105DKW ABC transporter HUN08_RS09475 ENOG4105VG1 fes assembly suf system protein HUN08_RS09480 ENOG4108UNV SUF system FeS assembly protein, NifU family HUN08_RS09490 ENOG4105C3K feS assembly ATPase SufC HUN08_RS09510 ENOG4107JC6 Membrane HUN08_RS09515 ENOG4105CJ1 ABC, transporter HUN08_RS09535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUN08_RS09540 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUN08_RS09550 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUN08_RS09570 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS09615 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUN08_RS09620 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUN08_RS09670 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUN08_RS09675 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUN08_RS09680 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUN08_RS09685 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUN08_RS09690 ENOG4105E5F proteasome HUN08_RS09695 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUN08_RS09710 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUN08_RS09715 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUN08_RS09740 ENOG4105C3R Methionine synthase HUN08_RS09755 ENOG4105C8N cysteinyl-tRNA synthetase HUN08_RS09775 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUN08_RS09860 ENOG4105CD5 CoA-binding domain protein HUN08_RS09865 ENOG4105DGU Histone deacetylase HUN08_RS09905 ENOG4105C5Q Transcriptional regulator HUN08_RS09910 ENOG4105D3R alkyl hydroperoxide reductase HUN08_RS09915 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUN08_RS09920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUN08_RS09925 ENOG4105CQ7 ATP-dependent helicase HUN08_RS09930 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUN08_RS09940 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUN08_RS09945 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUN08_RS09950 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUN08_RS09955 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUN08_RS09965 ENOG4105C99 atpase involved in dna repair HUN08_RS09970 ENOG4105KAC Antibiotic biosynthesis monooxygenase HUN08_RS09980 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUN08_RS09985 ENOG4105CDA abc transporter atp-binding protein HUN08_RS09990 ENOG4107UBR Extracellular solute-binding protein family 3 HUN08_RS09995 ENOG4108Q1T ABC transporter HUN08_RS10000 ENOG4105DRP amino acid AbC transporter HUN08_RS10005 ENOG4105KC9 Modulates RecA activity (By similarity) HUN08_RS10010 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUN08_RS10030 ENOG4105WBV Transcriptional regulator HUN08_RS10035 ENOG4105CEV competence damage-inducible protein HUN08_RS10060 ENOG4105CN5 Metallo-Beta-Lactamase HUN08_RS10065 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUN08_RS10070 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HUN08_RS10090 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUN08_RS10095 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUN08_RS10105 ENOG4105CSH Transporter HUN08_RS10145 ENOG4105DV0 amidase (EC 3.5.1.4 HUN08_RS10160 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUN08_RS10170 ENOG4108M8W Monooxygenase HUN08_RS10190 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUN08_RS10230 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUN08_RS10235 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUN08_RS10245 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUN08_RS10255 ENOG4105CRQ synthase (Component I) HUN08_RS10265 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUN08_RS10270 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUN08_RS10275 ENOG4108MWI inositol mono-phosphatase HUN08_RS10280 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUN08_RS10290 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUN08_RS10295 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUN08_RS10300 ENOG4105CIH Imidazole acetol-phosphate transaminase HUN08_RS10305 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUN08_RS10315 ENOG4105C26 Dehydrogenase HUN08_RS10345 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUN08_RS10350 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUN08_RS10355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUN08_RS10360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUN08_RS10415 ENOG4105CY3 ABC transporter, permease HUN08_RS10455 ENOG4105HDK L-asparaginase HUN08_RS10465 ENOG4108VJY integral membrane protein HUN08_RS10475 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUN08_RS10495 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUN08_RS10505 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUN08_RS10510 ENOG4105ME9 cell division protein FtsQ HUN08_RS10515 ENOG4105DFU Cell wall formation (By similarity) HUN08_RS10530 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUN08_RS10535 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUN08_RS10550 ENOG4105CJN penicillin-binding protein HUN08_RS10560 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUN08_RS10565 ENOG4108V6E Cell division protein mraZ HUN08_RS10595 ENOG4105EAH synthase HUN08_RS10605 ENOG41090CE integral membrane protein HUN08_RS10625 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUN08_RS10635 ENOG4108U8T Mannosyltransferase HUN08_RS10640 ENOG4105PSQ Acyl-transferase HUN08_RS10645 ENOG4105DKQ ROK family HUN08_RS10675 ENOG4105JNK Glycosyl transferase (Group 1 HUN08_RS10690 ENOG4105K4H Nlp p60 protein HUN08_RS10710 ENOG4108I0Q anthranilate phosphoribosyltransferase HUN08_RS10715 ENOG4105CCU oxidase (Subunit III) HUN08_RS10735 ENOG4108ZRS Part of cytochrome c oxidase, its function is HUN08_RS10740 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUN08_RS10755 ENOG4105DND Transcriptional regulator HUN08_RS10760 ENOG4107T4Z adenosine kinase HUN08_RS10780 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUN08_RS10790 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUN08_RS10800 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUN08_RS10815 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUN08_RS10820 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUN08_RS10845 ENOG4105C5F glutamine synthetase HUN08_RS10860 ENOG4105C57 major facilitator superfamily HUN08_RS10885 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUN08_RS10890 ENOG4105C5F glutamine synthetase HUN08_RS10895 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUN08_RS10905 ENOG4105C0H protease HUN08_RS10910 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HUN08_RS10940 ENOG4105KJF protein tyrosine phosphatase HUN08_RS11030 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUN08_RS11050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUN08_RS11070 ENOG4107S1E Beta-lactamase HUN08_RS11085 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS11090 ENOG4105CGU Enoyl-CoA hydratase HUN08_RS11135 ENOG4105VRR gCN5-related N-acetyltransferase HUN08_RS11155 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUN08_RS11165 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUN08_RS11205 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) HUN08_RS11220 ENOG4108WYP Transcriptional regulator HUN08_RS11285 ENOG4105C09 Bile acid HUN08_RS11290 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUN08_RS11300 ENOG4105VEQ Cold shock protein HUN08_RS11310 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUN08_RS11340 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUN08_RS11345 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUN08_RS11355 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUN08_RS11370 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUN08_RS11390 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUN08_RS11395 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUN08_RS11415 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUN08_RS11455 ENOG4108IJ6 ABC transporter HUN08_RS11460 ENOG4105ECW sulfate abc transporter HUN08_RS11465 ENOG4107Z6A sulfate abc transporter permease HUN08_RS11470 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUN08_RS11480 ENOG4105DGW oligopeptidase A HUN08_RS11485 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUN08_RS11510 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUN08_RS11520 ENOG4105KQC Competence protein HUN08_RS11545 ENOG4108TZC HUN08_RS11555 ENOG4107ZFZ Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUN08_RS11560 ENOG4105C85 amino acid HUN08_RS11565 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUN08_RS11575 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB HUN08_RS11580 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUN08_RS11610 ENOG4105CB5 ATP-dependent DNA helicase recG HUN08_RS11620 ENOG4105VB9 50S ribosomal protein l28 HUN08_RS11625 ENOG4108UKI Enoyl-CoA hydratase HUN08_RS11645 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUN08_RS11650 ENOG4108Z0R Transferase HUN08_RS11665 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUN08_RS11695 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUN08_RS11700 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUN08_RS11725 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUN08_RS11735 ENOG4105ERH Fumarylacetoacetate hydrolase HUN08_RS11740 ENOG4105E5T Major Facilitator Superfamily HUN08_RS11745 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUN08_RS11760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUN08_RS11765 ENOG4108ZP8 Acetolactate synthase small subunit HUN08_RS11780 ENOG4105C01 Dihydroxy-acid dehydratase HUN08_RS11795 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUN08_RS11830 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUN08_RS11840 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUN08_RS11855 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUN08_RS11890 ENOG4105E9Q Acyl-transferase HUN08_RS11900 ENOG4105C10 Electron transfer flavoprotein HUN08_RS11920 ENOG4108KQJ Type 11 methyltransferase HUN08_RS11935 ENOG4105EVB acetyltransferase HUN08_RS11940 ENOG4108V0V Pyrrolo-quinoline quinone HUN08_RS11955 ENOG4105UPE Enoyl-CoA hydratase HUN08_RS11975 ENOG4105DKW ABC transporter HUN08_RS11980 ENOG4105DEN Luciferase family HUN08_RS11985 ENOG4108WKN secreted protein HUN08_RS11990 ENOG4108WKN secreted protein HUN08_RS12000 ENOG4105EAC phosphoserine phosphatase HUN08_RS12020 ENOG4105C0D helicase HUN08_RS12065 ENOG4105V1F Fermentation respiration switch protein HUN08_RS12120 ENOG4105EIP mannose-6-phosphate isomerase HUN08_RS12140 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUN08_RS12150 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUN08_RS12160 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUN08_RS12180 ENOG4105C3Q Glycosyl transferase, family 2 HUN08_RS12185 ENOG4105EEI dihydropteroate synthase HUN08_RS12195 ENOG4108URH decarboxylase HUN08_RS12200 ENOG4108URH decarboxylase HUN08_RS12230 ENOG4108Z4U Ferredoxin HUN08_RS12235 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUN08_RS12245 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUN08_RS12270 ENOG4105D38 putrescine abc transporter HUN08_RS12350 ENOG4105DVF Cytosine-specific methyltransferase HUN08_RS12395 ENOG4105C2M dna polymerase I HUN08_RS12420 ENOG4107VC8 ATP cone domain protein HUN08_RS12740 ENOG41082BM Transcriptional regulator, arsr family HUN08_RS12785 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUN08_RS12790 ENOG4105CBG Sulfatase HUN08_RS12795 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUN08_RS12830 ENOG4105DB4 HUN08_RS12835 ENOG4105C3G gtp-binding protein HUN08_RS12845 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HUN08_RS12860 ENOG4105EEF Alkane 1-monooxygenase HUN08_RS12865 ENOG41084UD rubredoxin HUN08_RS12870 ENOG4105VCQ rubredoxin HUN08_RS12910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUN08_RS12925 ENOG4107QRP cobalamin biosynthesis protein CobW HUN08_RS12930 ENOG4105C72 UPF0176 protein HUN08_RS12945 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HUN08_RS12950 ENOG4105CSV Glutaminase HUN08_RS12965 ENOG4105C57 major facilitator superfamily HUN08_RS12995 ENOG4105BZU Histidine kinase HUN08_RS13045 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HUN08_RS13070 ENOG41061MV Arylsulfatase HUN08_RS13090 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUN08_RS13095 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUN08_RS13100 ENOG4105CAK Cell division ATP-binding protein ftsE HUN08_RS13110 ENOG4105D8X mechanosensitive ion channel HUN08_RS13115 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUN08_RS13125 ENOG4107TK4 histidinol-phosphate phosphatase HUN08_RS13130 ENOG4105CBC glutamate synthase HUN08_RS13165 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS13285 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUN08_RS13295 ENOG4105K6V RNA polymerase HUN08_RS13345 ENOG4105CSR polyphosphate kinase 2 HUN08_RS13360 ENOG4105DJZ UPF0182 protein HUN08_RS13375 ENOG41063PX domain protein HUN08_RS13390 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUN08_RS13395 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUN08_RS13420 ENOG4105C4R Atp-dependent dna helicase HUN08_RS13430 ENOG4108YIQ Alpha beta hydrolase HUN08_RS13495 ENOG4105C1J atp-dependent rna helicase HUN08_RS13505 ENOG4107QJE Chromosome Partitioning Protein HUN08_RS13515 ENOG4105CBD Diacylglycerol kinase HUN08_RS13530 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HUN08_RS13545 ENOG4108RAV Conserved protein HUN08_RS13565 ENOG4107RN6 Monooxygenase HUN08_RS13575 ENOG4105CQB FAD linked oxidase domain protein HUN08_RS13585 ENOG4105Y3U Transglycosylase-associated protein HUN08_RS13610 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUN08_RS13620 ENOG4105D82 Glutamate dehydrogenase HUN08_RS13630 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUN08_RS13635 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUN08_RS13690 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUN08_RS13695 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUN08_RS13705 ENOG4108T3R lipoprotein lpqB HUN08_RS13710 ENOG4105BZU Histidine kinase HUN08_RS13720 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUN08_RS13740 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUN08_RS13745 ENOG4105CUB amino acid HUN08_RS13805 ENOG4108ZT0 50S ribosomal protein l17 HUN08_RS13815 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUN08_RS13820 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUN08_RS13825 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUN08_RS13830 ENOG41067V7 50S ribosomal protein L36 HUN08_RS13845 ENOG4105GSW HUN08_RS13885 ENOG41082T9 Membrane HUN08_RS13900 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUN08_RS13910 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUN08_RS13920 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUN08_RS13925 ENOG410849U 50S ribosomal protein L30 HUN08_RS13930 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUN08_RS13935 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUN08_RS13940 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUN08_RS13945 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUN08_RS13955 ENOG4108IUE nitrate reductase beta subunit HUN08_RS14015 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUN08_RS14020 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUN08_RS14025 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUN08_RS14030 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUN08_RS14055 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS14080 ENOG4108TEB UPF0114 protein HUN08_RS14085 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUN08_RS14090 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUN08_RS14105 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUN08_RS14110 ENOG41082SA 50s ribosomal protein l29 HUN08_RS14115 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUN08_RS14120 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUN08_RS14130 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUN08_RS14135 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUN08_RS14145 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUN08_RS14150 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUN08_RS14180 ENOG4106BQ7 Glycosyl Transferase HUN08_RS14235 ENOG4105XDV HUN08_RS14295 ENOG4105EMU Dehydrogenase HUN08_RS14320 ENOG4107TCW O-succinylbenzoate synthase HUN08_RS14350 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUN08_RS14355 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUN08_RS14360 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUN08_RS14365 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUN08_RS14390 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUN08_RS14395 ENOG4105C0A alcohol dehydrogenase HUN08_RS14410 ENOG4105KNY Microcompartments protein HUN08_RS14440 ENOG4105CGK Exodeoxyribonuclease III HUN08_RS14445 ENOG41073TP transcriptional regulator HUN08_RS14450 ENOG4105DJ2 Major Facilitator Superfamily HUN08_RS14460 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUN08_RS14465 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUN08_RS14485 ENOG4108IG5 Transcriptional regulator HUN08_RS14490 ENOG41060WC Enoyl-CoA hydratase HUN08_RS14505 ENOG4107QX3 carboxylase HUN08_RS14530 ENOG41082BM Transcriptional regulator, arsr family HUN08_RS14570 ENOG4107FW0 short-chain dehydrogenase reductase HUN08_RS14640 ENOG4105T0Z Conserved Protein HUN08_RS14655 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUN08_RS14660 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUN08_RS14675 ENOG4107XZ0 Peptidase M50 HUN08_RS14680 ENOG4105KVH Transcriptional regulator HUN08_RS14720 ENOG4105GCF PGAM HUN08_RS14735 ENOG4106178 UPF0339 protein HUN08_RS14760 ENOG4108KQ5 Integrase catalytic subunit HUN08_RS14780 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS14790 ENOG4105PP6 Membrane HUN08_RS14840 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUN08_RS14870 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUN08_RS14875 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUN08_RS14940 ENOG4108VZM 50s ribosomal protein L10 HUN08_RS15020 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUN08_RS15025 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUN08_RS15045 ENOG410900P UPF0336 protein HUN08_RS15050 ENOG4105WDJ 50S ribosomal protein L33 HUN08_RS15070 ENOG4108VPT UPF0234 protein HUN08_RS15075 ENOG4108KQ5 Integrase catalytic subunit HUN08_RS15080 ENOG4105D0M Protease HtpX homolog HUN08_RS15090 ENOG4105P52 geranylgeranyl reductase HUN08_RS15100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUN08_RS15115 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HUN08_RS15125 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUN08_RS15130 ENOG4105EG6 Saccharopine dehydrogenase HUN08_RS15150 ENOG4105DYW oxidoreductase HUN08_RS15195 ENOG4105DFA alanine racemase domain protein HUN08_RS15200 ENOG4108KQ5 Integrase catalytic subunit HUN08_RS15205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUN08_RS15210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUN08_RS15235 ENOG4105CRE cytochrome C HUN08_RS15245 ENOG4107QIV Cytochrome c biogenesis protein HUN08_RS15250 ENOG4107ZT5 Thiol disulfide interchange protein HUN08_RS15255 ENOG4108RH7 phosphoglycerate mutase HUN08_RS15260 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUN08_RS15265 ENOG4108VQR secreted hydrolase HUN08_RS15275 ENOG4105CH2 amidohydrolase HUN08_RS15305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUN08_RS15310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUN08_RS15315 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUN08_RS15320 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUN08_RS15385 ENOG41063NU Membrane HUN08_RS15415 ENOG4105BZU Histidine kinase HUN08_RS15425 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUN08_RS15430 ENOG4108YZJ Pfam:DUF2596 HUN08_RS15435 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUN08_RS15440 ENOG4108VJY integral membrane protein HUN08_RS15460 ENOG4105FDK ABC transporter HUN08_RS15465 ENOG4105CC5 ABC transporter HUN08_RS15480 ENOG4105EBR Carboxylesterase HUN08_RS15495 ENOG4105C8N cysteinyl-tRNA synthetase HUN08_RS15500 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUN08_RS15505 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUN08_RS15510 ENOG4108VJ1 Transcriptional regulator (CarD family HUN08_RS15515 ENOG41062GB lipoprotein lpqE HUN08_RS15520 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUN08_RS15530 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUN08_RS15545 ENOG4105CEN a g-specific adenine glycosylase HUN08_RS15625 ENOG4105X7H acyl-CoA dehydrogenase HUN08_RS15630 ENOG4108KC2 acyl-Coa dehydrogenase HUN08_RS15635 ENOG4105J5T Amp-dependent synthetase and ligase HUN08_RS15640 ENOG4107W6X Transcriptional regulator HUN08_RS15655 ENOG4105C26 Dehydrogenase HUN08_RS15670 ENOG410846T CoA-transferase family III HUN08_RS15680 ENOG4105E39 Enoyl-CoA hydratase HUN08_RS15715 ENOG4105DR5 peptidase HUN08_RS15740 ENOG4105E39 Enoyl-CoA hydratase HUN08_RS15815 ENOG4108KPJ rna polymerase sigma factor HUN08_RS15820 ENOG4105CEP NADH dehydrogenase HUN08_RS15835 ENOG4106A3M Cytochrome p-450 HUN08_RS15840 ENOG4105F2C Acetyl-CoA acetyltransferase HUN08_RS15865 ENOG4106A3M Cytochrome p-450 HUN08_RS15875 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS15885 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUN08_RS15895 ENOG4105E39 Enoyl-CoA hydratase HUN08_RS15910 ENOG4105EA8 2-Nitropropane dioxygenase HUN08_RS15915 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUN08_RS15930 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUN08_RS15935 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUN08_RS15945 ENOG4108RZE Tetr family transcriptional regulator HUN08_RS15960 ENOG4107RGH Aldehyde dehydrogenase HUN08_RS15965 ENOG4105F2C Acetyl-CoA acetyltransferase HUN08_RS15975 ENOG4105CC9 acyl-Coa dehydrogenase HUN08_RS15980 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS16005 ENOG4105CRK lysyL-tRNA synthetase HUN08_RS16030 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUN08_RS16035 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUN08_RS16040 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUN08_RS16080 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUN08_RS16085 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUN08_RS16095 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUN08_RS16115 ENOG4105E4F Isochorismate synthase HUN08_RS16160 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUN08_RS16170 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUN08_RS16190 ENOG4105C4B ABC transporter, permease HUN08_RS16210 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUN08_RS16215 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUN08_RS16230 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUN08_RS16245 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUN08_RS16250 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUN08_RS16265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUN08_RS16300 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS16340 ENOG4105KNI merR family transcriptional Regulator HUN08_RS16345 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUN08_RS16350 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUN08_RS16355 ENOG4105CFG Acts as a chaperone (By similarity) HUN08_RS16415 ENOG4105DF6 Fe-S oxidoreductase HUN08_RS16455 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUN08_RS16460 ENOG4107TE1 transport protein HUN08_RS16465 ENOG4105DHP deoxycytidine triphosphate deaminase HUN08_RS16470 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUN08_RS16475 ENOG4108IXY short-chain dehydrogenase reductase HUN08_RS16480 ENOG41064MX Tetr family transcriptional regulator HUN08_RS16520 ENOG4105EDR glucose galactose transporter HUN08_RS16570 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 HUN08_RS16610 ENOG4105KVH Transcriptional regulator HUN08_RS16620 ENOG41063C6 UPF0235 protein HUN08_RS16625 ENOG4108R3E Dna-3-methyladenine glycosylase i HUN08_RS16635 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HUN08_RS16645 ENOG41061MV Arylsulfatase HUN08_RS16680 ENOG4108PJD permease HUN08_RS16695 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS16755 ENOG4105KK4 UPF0060 membrane protein HUN08_RS16765 ENOG4105CSU acyl-Coa dehydrogenase HUN08_RS16780 ENOG4105CVK Glutamate decarboxylase HUN08_RS16800 ENOG4105CHR reductase HUN08_RS16820 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUN08_RS16830 ENOG41090MF Protein of unknown function (DUF3068) HUN08_RS16870 ENOG4105DEG Vwa containing coxe family protein HUN08_RS16880 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUN08_RS16885 ENOG4108KDT Molybdate metabolism regulator HUN08_RS16895 ENOG4105CZA synthase HUN08_RS16900 ENOG4105VUN Transcriptional regulator HUN08_RS16910 ENOG4105BZ4 penicillin-binding protein HUN08_RS16935 ENOG41086VY Fic/DOC family HUN08_RS16945 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUN08_RS16960 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUN08_RS17005 ENOG4105C0D helicase HUN08_RS17075 ENOG4105F5W AtP-binding protein HUN08_RS17110 ENOG4105C26 Dehydrogenase HUN08_RS17115 ENOG4105EMU Dehydrogenase HUN08_RS17125 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS17140 ENOG4105C57 major facilitator superfamily HUN08_RS17180 ENOG4105KVH Transcriptional regulator HUN08_RS17200 ENOG4107YNJ LysR family Transcriptional regulator HUN08_RS17205 ENOG4105C26 Dehydrogenase HUN08_RS17240 ENOG4105C0D helicase HUN08_RS17245 ENOG4105CEY Amp-dependent synthetase and ligase HUN08_RS17260 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUN08_RS17300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUN08_RS17305 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS17315 ENOG4108QER Adenylate cyclase HUN08_RS17335 ENOG4108UW5 maltose o-acetyltransferase HUN08_RS17350 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17375 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F HUN08_RS17385 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUN08_RS17395 ENOG4105CPQ Dehydrogenase HUN08_RS17400 ENOG4105EA8 2-Nitropropane dioxygenase HUN08_RS17405 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS17410 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17415 ENOG410846T CoA-transferase family III HUN08_RS17420 ENOG4105VC4 domain protein HUN08_RS17425 ENOG4105C26 Dehydrogenase HUN08_RS17435 ENOG4108RZE Tetr family transcriptional regulator HUN08_RS17450 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17460 ENOG4105C26 Dehydrogenase HUN08_RS17475 ENOG410846T CoA-transferase family III HUN08_RS17480 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUN08_RS17495 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17500 ENOG4105CI0 Citrate lyase HUN08_RS17510 ENOG4108M9J MaoC like domain protein HUN08_RS17555 ENOG4105CHU acetyl-coa acetyltransferase HUN08_RS17560 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17580 ENOG4107W6X Transcriptional regulator HUN08_RS17590 ENOG4105DXD 2-methylcitrate dehydratase HUN08_RS17610 ENOG4105C2J ABC transporter HUN08_RS17620 ENOG4105CNN ABC, transporter HUN08_RS17630 ENOG4105CNN ABC, transporter HUN08_RS17635 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS17640 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUN08_RS17645 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUN08_RS17675 ENOG4107ZR7 Membrane HUN08_RS17680 ENOG4105DUM transcriptional regulator, lysR family HUN08_RS17685 ENOG4105DMF Dehydrogenase HUN08_RS17695 ENOG4105CT3 Monooxygenase HUN08_RS17725 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUN08_RS17730 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUN08_RS17785 ENOG4107EFR Flavocytochrome c HUN08_RS17795 ENOG4105VPX protein, conserved in bacteria HUN08_RS17825 ENOG41090MF Protein of unknown function (DUF3068) HUN08_RS17860 ENOG4105EZR dyp-type peroxidase family protein HUN08_RS17890 ENOG4105C1G acyl-Coa dehydrogenase HUN08_RS17915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUN08_RS17955 ENOG410834F Transcriptional regulator HUN08_RS17960 ENOG4105DXB Major Facilitator superfamily HUN08_RS17975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUN08_RS17980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUN08_RS17985 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUN08_RS18000 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUN08_RS18015 ENOG4105WH1 Two component transcriptional regulator luxr family HUN08_RS18020 ENOG4108XG2 Histidine kinase HUN08_RS18050 ENOG4105C9K Endothelin-converting enzyme 1 HUN08_RS18090 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUN08_RS18095 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUN08_RS18110 ENOG4105C8T Leucyl-tRNA synthetase HUN08_RS18120 ENOG4105DHU Bile acid HUN08_RS18145 ENOG4105C92 Aminotransferase class V HUN08_RS18155 ENOG410901E Membrane HUN08_RS18180 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUN08_RS18210 ENOG4105C3M thioredoxin reductase HUN08_RS18215 ENOG4105K63 Thioredoxin HUN08_RS18220 ENOG4108E1C hydrolase HUN08_RS18235 ENOG4107QJE Chromosome Partitioning Protein HUN08_RS18240 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUN08_RS18250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUN08_RS18255 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUN08_RS18260 ENOG410864Q RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)