locus-tag	class	description
GFO_RS00015	COG3665	Urea carboxylase-associated protein
GFO_RS00020	COG0861	Integral membrane protein TerC family
GFO_RS00030	COG0745	RESPONSE REGULATOR receiver
GFO_RS00030	COG3292	Two component regulator propeller
GFO_RS00030	COG2205	protein histidine kinase activity
GFO_RS00035	COG2814	Major facilitator Superfamily
GFO_RS00040	COG1621	beta-fructofuranosidase activity
GFO_RS00045	COG4771	TonB-dependent receptor
GFO_RS00055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFO_RS00060	COG2076	Multidrug Resistance protein
GFO_RS00070	COG1215	transferase activity, transferring glycosyl groups
GFO_RS00110	COG2217	Heavy metal translocating P-type atpase
GFO_RS00145	COG3250	beta-galactosidase activity
GFO_RS00150	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GFO_RS00160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFO_RS00165	COG4206	TonB-dependent receptor
GFO_RS00165	COG1629	transport
GFO_RS00170	COG0745	RESPONSE REGULATOR receiver
GFO_RS00170	COG2205	protein histidine kinase activity
GFO_RS00170	COG3292	Two component regulator propeller
GFO_RS00180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFO_RS00185	COG4221	oxidoreductase activity
GFO_RS00190	COG1902	pentaerythritol trinitrate reductase activity
GFO_RS00205	COG1522	sequence-specific DNA binding
GFO_RS00230	COG0668	transmembrane transport
GFO_RS00280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFO_RS00295	COG4628	conserved protein (DUF2132)
GFO_RS00315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFO_RS00320	COG2315	Protein conserved in bacteria
GFO_RS00350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFO_RS00355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFO_RS00360	COG0463	Glycosyl transferase, family 2
GFO_RS00395	COG2072	flavoprotein involved in K transport
GFO_RS00415	COG0084	hydrolase, TatD family'
GFO_RS00425	COG0252	asparaginase activity
GFO_RS00435	COG0811	peptide transport
GFO_RS00445	COG0848	biopolymer transport protein
GFO_RS00465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GFO_RS00475	COG0017	Asparaginyl-tRNA synthetase
GFO_RS00490	COG0233	cytoplasmic translational termination
GFO_RS00495	COG0528	UMP kinase activity
GFO_RS00500	COG2738	Putative neutral zinc metallopeptidase
GFO_RS00505	COG1522	sequence-specific DNA binding
GFO_RS00515	COG2363	Small membrane protein
GFO_RS00520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFO_RS00535	COG0463	Glycosyl transferase, family 2
GFO_RS00540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFO_RS00555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFO_RS00575	COG4771	TonB-dependent receptor
GFO_RS00580	COG0745	RESPONSE REGULATOR receiver
GFO_RS00585	COG5002	protein histidine kinase activity
GFO_RS00590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFO_RS00595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFO_RS00610	COG0489	protein tyrosine kinase activity
GFO_RS00620	COG0492	ferredoxin-NADP+ reductase activity
GFO_RS00645	COG1960	acyl-CoA dehydrogenase activity
GFO_RS00650	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFO_RS00655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFO_RS00660	COG0052	Belongs to the universal ribosomal protein uS2 family
GFO_RS00665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFO_RS00670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFO_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFO_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFO_RS00695	COG1446	asparaginase
GFO_RS00700	COG1408	metallophosphoesterase
GFO_RS00705	COG3118	belongs to the thioredoxin family
GFO_RS00735	COG2201	protein-glutamate methylesterase activity
GFO_RS00760	COG0589	response to stress
GFO_RS00765	COG0779	Required for maturation of 30S ribosomal subunits
GFO_RS00770	COG2251	uridine kinase activity
GFO_RS00770	COG0195	Participates in both transcription termination and antitermination
GFO_RS00775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFO_RS00790	COG0437	4 iron, 4 sulfur cluster binding
GFO_RS00820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFO_RS00825	COG2255	four-way junction helicase activity
GFO_RS00830	COG2827	Endonuclease containing a URI domain
GFO_RS00840	COG2205	protein histidine kinase activity
GFO_RS00840	COG3292	Two component regulator propeller
GFO_RS00840	COG0745	RESPONSE REGULATOR receiver
GFO_RS00845	COG0277	FAD linked oxidase domain protein
GFO_RS00855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFO_RS00870	COG0280	phosphate acetyltransferase
GFO_RS00870	COG0281	malic enzyme
GFO_RS00875	COG0632	four-way junction helicase activity
GFO_RS00885	COG0509	glycine decarboxylation via glycine cleavage system
GFO_RS00910	COG0109	protoheme IX farnesyltransferase activity
GFO_RS00915	COG1845	cytochrome c oxidase, subunit III
GFO_RS00935	COG1999	signal sequence binding
GFO_RS00940	COG2322	membrane
GFO_RS00950	COG1136	(ABC) transporter
GFO_RS00955	COG0577	efflux transmembrane transporter activity
GFO_RS00955	COG1136	(ABC) transporter
GFO_RS00960	COG1136	(ABC) transporter
GFO_RS00960	COG0577	efflux transmembrane transporter activity
GFO_RS00965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFO_RS00980	COG1214	PFAM Peptidase M22, glycoprotease
GFO_RS00985	COG0668	transmembrane transport
GFO_RS00990	COG1331	Highly conserved protein containing a thioredoxin domain
GFO_RS01010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFO_RS01040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFO_RS01050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GFO_RS01055	COG0596	Alpha beta hydrolase
GFO_RS01070	COG1950	PFAM Membrane protein of
GFO_RS01075	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFO_RS01085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFO_RS01110	COG0739	heme binding
GFO_RS01115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFO_RS01140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFO_RS01150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GFO_RS01160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFO_RS01165	COG0110	maltose O-acetyltransferase activity
GFO_RS01190	COG1428	Deoxynucleoside kinase
GFO_RS01200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFO_RS01225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFO_RS01255	COG1002	Type II restriction enzyme, methylase subunits
GFO_RS01280	COG0612	Peptidase, M16
GFO_RS01320	COG1519	Transferase
GFO_RS01335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFO_RS01340	COG3871	stress protein (general stress protein 26)
GFO_RS01350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFO_RS01380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFO_RS01395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFO_RS01400	COG1295	ribonuclease BN
GFO_RS01405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GFO_RS01415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFO_RS01420	COG2086	electron transfer activity
GFO_RS01425	COG0022	dehydrogenase e1 component
GFO_RS01425	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS01435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GFO_RS01440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GFO_RS01450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFO_RS01470	COG1428	Deoxynucleoside kinase
GFO_RS01490	COG3273	potassium ion transport
GFO_RS01490	COG0471	metal ion transport
GFO_RS01495	COG1228	amidohydrolase
GFO_RS01500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFO_RS01505	COG0589	response to stress
GFO_RS01510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFO_RS01515	COG1960	acyl-CoA dehydrogenase activity
GFO_RS01520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFO_RS01530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GFO_RS01535	COG0527	aspartate kinase activity
GFO_RS01535	COG0460	homoserine dehydrogenase
GFO_RS01545	COG1959	2 iron, 2 sulfur cluster binding
GFO_RS01555	COG0175	sulfate reduction
GFO_RS01560	COG0175	sulfate reduction
GFO_RS01570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFO_RS01575	COG1648	precorrin-2 dehydrogenase activity
GFO_RS01575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFO_RS01580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFO_RS01580	COG1648	precorrin-2 dehydrogenase activity
GFO_RS01585	COG0492	ferredoxin-NADP+ reductase activity
GFO_RS01605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFO_RS01620	COG1131	(ABC) transporter
GFO_RS01625	COG0077	Prephenate dehydratase
GFO_RS01625	COG1605	Chorismate mutase
GFO_RS01640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFO_RS01650	COG1162	GTPase activity
GFO_RS01655	COG1490	D-aminoacyl-tRNA deacylase activity
GFO_RS01685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFO_RS01690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFO_RS01720	COG3119	arylsulfatase activity
GFO_RS01730	COG4771	TonB-dependent receptor
GFO_RS01735	COG0702	epimerase
GFO_RS01760	COG1472	Belongs to the glycosyl hydrolase 3 family
GFO_RS01765	COG3250	beta-galactosidase activity
GFO_RS01800	COG0492	ferredoxin-NADP+ reductase activity
GFO_RS01815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFO_RS01820	COG1185	polyribonucleotide nucleotidyltransferase activity
GFO_RS01825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFO_RS01830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFO_RS01835	COG0191	fructose-bisphosphate aldolase activity
GFO_RS01855	COG2226	methyltransferase
GFO_RS01870	COG0436	Aminotransferase
GFO_RS01875	COG0357	Ribosomal RNA small subunit methyltransferase G
GFO_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS01920	COG1805	sodium ion transport
GFO_RS01935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GFO_RS01950	COG1477	protein flavinylation
GFO_RS01980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GFO_RS02000	COG0740	serine-type endopeptidase activity
GFO_RS02005	COG0456	acetyltransferase
GFO_RS02035	COG0101	tRNA pseudouridine synthase activity
GFO_RS02040	COG1132	(ABC) transporter
GFO_RS02050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFO_RS02055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFO_RS02070	COG0149	triose-phosphate isomerase activity
GFO_RS02075	COG2264	protein methyltransferase activity
GFO_RS02080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFO_RS02090	COG2080	2 iron, 2 sulfur cluster binding
GFO_RS02095	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GFO_RS02100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFO_RS02120	COG1104	cysteine desulfurase activity
GFO_RS02125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFO_RS02130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFO_RS02140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFO_RS02150	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFO_RS02150	COG0315	cyclic pyranopterin monophosphate synthase activity
GFO_RS02160	COG0303	'Molybdopterin
GFO_RS02175	COG4585	Histidine kinase
GFO_RS02195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFO_RS02235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFO_RS02245	COG1120	ATPase activity
GFO_RS02260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFO_RS02265	COG0284	orotidine-5'-phosphate decarboxylase activity
GFO_RS02270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFO_RS02285	COG0788	formyltetrahydrofolate deformylase activity
GFO_RS02290	COG1703	isobutyryl-CoA mutase activity
GFO_RS02290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFO_RS02290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFO_RS02305	COG1522	sequence-specific DNA binding
GFO_RS02335	COG0004	ammonium transporteR
GFO_RS02345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFO_RS02365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFO_RS02375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GFO_RS02375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFO_RS02380	COG1090	epimerase
GFO_RS02390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFO_RS02395	COG0484	heat shock protein binding
GFO_RS02400	COG4152	abc transporter atp-binding protein
GFO_RS02410	COG3264	Mechanosensitive ion channel
GFO_RS02410	COG1196	nuclear chromosome segregation
GFO_RS02430	COG2326	polyphosphate kinase activity
GFO_RS02440	COG0534	Mate efflux family protein
GFO_RS02450	COG0671	phosphoesterase, PA-phosphatase related
GFO_RS02455	COG1703	isobutyryl-CoA mutase activity
GFO_RS02460	COG1764	response to oxidative stress
GFO_RS02470	COG4941	Belongs to the sigma-70 factor family
GFO_RS02515	COG0653	protein targeting
GFO_RS02535	COG1136	(ABC) transporter
GFO_RS02545	COG0488	(ABC) transporter
GFO_RS02555	COG0489	protein tyrosine kinase activity
GFO_RS02605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFO_RS02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS02610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFO_RS02620	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFO_RS02635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS02640	COG1216	Glycosyl transferase, family 2
GFO_RS02655	COG1215	transferase activity, transferring glycosyl groups
GFO_RS02660	COG1216	Glycosyl transferase, family 2
GFO_RS02700	COG2089	acid synthase
GFO_RS02715	COG1083	cytidylyl-transferase
GFO_RS02720	COG0367	asparagine synthase
GFO_RS02775	COG0438	transferase activity, transferring glycosyl groups
GFO_RS02780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFO_RS02785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFO_RS02795	COG1137	ATPase activity
GFO_RS02805	COG0805	protein transport
GFO_RS02810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFO_RS02810	COG0517	IMP dehydrogenase activity
GFO_RS02815	COG0514	ATP-dependent DNA helicase (RecQ)
GFO_RS02825	COG3958	Transketolase
GFO_RS02830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFO_RS02835	COG0343	queuine tRNA-ribosyltransferase activity
GFO_RS02845	COG0825	malonyl-CoA metabolic process
GFO_RS02850	COG0305	Participates in initiation and elongation during chromosome replication
GFO_RS02865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFO_RS02870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFO_RS02875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFO_RS02880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFO_RS02945	COG0335	large ribosomal subunit rRNA binding
GFO_RS02950	COG0336	Belongs to the RNA methyltransferase TrmD family
GFO_RS02965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFO_RS02970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFO_RS02980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFO_RS02990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFO_RS02995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFO_RS03000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFO_RS03005	COG0824	Thioesterase
GFO_RS03010	COG1739	Uncharacterized protein family UPF0029
GFO_RS03015	COG0697	spore germination
GFO_RS03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFO_RS03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFO_RS03035	COG2890	protein-(glutamine-N5) methyltransferase activity
GFO_RS03040	COG1611	Belongs to the LOG family
GFO_RS03050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFO_RS03060	COG0737	Belongs to the 5'-nucleotidase family
GFO_RS03065	COG0737	Belongs to the 5'-nucleotidase family
GFO_RS03080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFO_RS03105	COG0497	DNA recombination
GFO_RS03110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFO_RS03125	COG0237	dephospho-CoA kinase activity
GFO_RS03145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFO_RS03150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFO_RS03165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFO_RS03175	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFO_RS03185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFO_RS03200	COG4974	Belongs to the 'phage' integrase family
GFO_RS03235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFO_RS03265	COG1629	transport
GFO_RS03270	COG0702	epimerase
GFO_RS03275	COG3534	alpha-L-arabinofuranosidase
GFO_RS03290	COG3507	Belongs to the glycosyl hydrolase 43 family
GFO_RS03295	COG3507	Belongs to the glycosyl hydrolase 43 family
GFO_RS03300	COG3940	Belongs to the glycosyl hydrolase 43 family
GFO_RS03310	COG1069	ribulokinase activity
GFO_RS03315	COG0235	Class ii aldolase
GFO_RS03320	COG2160	L-arabinose isomerase activity
GFO_RS03335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFO_RS03345	COG3958	Transketolase
GFO_RS03370	COG1136	(ABC) transporter
GFO_RS03375	COG0577	efflux transmembrane transporter activity
GFO_RS03385	COG1136	(ABC) transporter
GFO_RS03385	COG0577	efflux transmembrane transporter activity
GFO_RS03395	COG0577	efflux transmembrane transporter activity
GFO_RS03400	COG0577	efflux transmembrane transporter activity
GFO_RS03405	COG1136	(ABC) transporter
GFO_RS03435	COG3189	MarR family transcriptional regulator
GFO_RS03450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFO_RS03455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFO_RS03465	COG3852	Histidine kinase
GFO_RS03485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFO_RS03490	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS03505	COG3279	Response regulator of the LytR AlgR family
GFO_RS03510	COG3275	phosphorelay sensor kinase activity
GFO_RS03515	COG1272	protein, Hemolysin III
GFO_RS03530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFO_RS03530	COG0189	ligase activity
GFO_RS03535	COG4242	Belongs to the peptidase S51 family
GFO_RS03540	COG1446	asparaginase
GFO_RS03550	COG0019	diaminopimelate decarboxylase activity
GFO_RS03555	COG2814	Major facilitator Superfamily
GFO_RS03560	COG0045	succinate-CoA ligase (ADP-forming) activity
GFO_RS03570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFO_RS03595	COG1228	amidohydrolase
GFO_RS03605	COG1064	alcohol dehydrogenase
GFO_RS03610	COG0626	cystathionine gamma-synthase activity
GFO_RS03615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFO_RS03625	COG3956	TIGRFAM MazG family protein
GFO_RS03640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFO_RS03660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFO_RS03680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFO_RS03690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFO_RS03695	COG0501	Belongs to the peptidase M48B family
GFO_RS03700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFO_RS03715	COG1228	amidohydrolase
GFO_RS03725	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFO_RS03730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFO_RS03740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFO_RS03750	COG0105	UTP biosynthetic process
GFO_RS03765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFO_RS03775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFO_RS03785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFO_RS03815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFO_RS03825	COG1475	DNA binding
GFO_RS03830	COG1192	Involved in chromosome partitioning
GFO_RS03835	COG0612	Peptidase, M16
GFO_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS03845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFO_RS03845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFO_RS03850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFO_RS03860	COG0572	uridine kinase
GFO_RS03870	COG2133	pyrroloquinoline quinone binding
GFO_RS03880	COG3263	regulation of cellular component size
GFO_RS03900	COG4221	oxidoreductase activity
GFO_RS03920	COG0745	RESPONSE REGULATOR receiver
GFO_RS03925	COG5002	protein histidine kinase activity
GFO_RS03955	COG1476	TRANSCRIPTIONal
GFO_RS03960	COG1368	sulfuric ester hydrolase activity
GFO_RS03990	COG2267	carboxylic ester hydrolase activity
GFO_RS03995	COG0656	L-ascorbic acid biosynthetic process
GFO_RS04010	COG0745	RESPONSE REGULATOR receiver
GFO_RS04015	COG1215	transferase activity, transferring glycosyl groups
GFO_RS04025	COG0745	RESPONSE REGULATOR receiver
GFO_RS04045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GFO_RS04050	COG0006	proline dipeptidase activity
GFO_RS04170	COG3177	Filamentation induced by cAMP protein fic
GFO_RS04350	COG4680	protein conserved in bacteria
GFO_RS04365	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFO_RS04365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFO_RS04420	COG3549	Plasmid maintenance system killer
GFO_RS04440	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GFO_RS04445	COG1396	sequence-specific DNA binding
GFO_RS04475	COG4974	Belongs to the 'phage' integrase family
GFO_RS04485	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS04495	COG0730	response to heat
GFO_RS04500	COG1271	oxidase subunit
GFO_RS04550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFO_RS04555	COG0511	ligase activity, forming carbon-carbon bonds
GFO_RS04555	COG5016	pyruvate
GFO_RS04560	COG0439	Biotin carboxylase
GFO_RS04565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFO_RS04615	COG2860	membrane
GFO_RS04620	COG0492	ferredoxin-NADP+ reductase activity
GFO_RS04680	COG0714	Associated with various cellular activities
GFO_RS04755	COG2972	Histidine kinase
GFO_RS04775	COG1595	DNA-templated transcription, initiation
GFO_RS04800	COG0673	inositol 2-dehydrogenase activity
GFO_RS04805	COG2211	Major facilitator Superfamily
GFO_RS04825	COG4771	TonB-dependent receptor
GFO_RS04855	COG1597	lipid kinase activity
GFO_RS04885	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFO_RS04890	COG3387	PFAM Glycoside hydrolase 15-related
GFO_RS04900	COG1960	acyl-CoA dehydrogenase activity
GFO_RS04905	COG0183	Belongs to the thiolase family
GFO_RS04915	COG1024	Enoyl-CoA hydratase
GFO_RS04915	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFO_RS04925	COG1022	Amp-dependent synthetase and ligase
GFO_RS04930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFO_RS04930	COG0047	phosphoribosylformylglycinamidine synthase activity
GFO_RS04940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFO_RS04940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFO_RS04970	COG1132	(ABC) transporter
GFO_RS04975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFO_RS04980	COG0463	Glycosyl transferase, family 2
GFO_RS04990	COG0254	rRNA binding
GFO_RS05005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFO_RS05015	COG1741	Belongs to the pirin family
GFO_RS05025	COG0741	lytic transglycosylase activity
GFO_RS05025	COG1388	LysM domain
GFO_RS05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFO_RS05040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFO_RS05050	COG2363	Small membrane protein
GFO_RS05065	COG1607	acyl-coa hydrolase
GFO_RS05085	COG1120	ATPase activity
GFO_RS05090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFO_RS05100	COG4206	TonB-dependent receptor
GFO_RS05110	COG0793	Belongs to the peptidase S41A family
GFO_RS05145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFO_RS05175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFO_RS05180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GFO_RS05205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFO_RS05210	COG3279	Response regulator of the LytR AlgR family
GFO_RS05215	COG0360	Binds together with S18 to 16S ribosomal RNA
GFO_RS05220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFO_RS05225	COG0359	binds to the 23S rRNA
GFO_RS05240	COG0124	histidyl-tRNA synthetase
GFO_RS05245	COG0667	Aldo Keto reductase
GFO_RS05315	COG0640	Transcriptional regulator
GFO_RS05360	COG1741	Belongs to the pirin family
GFO_RS05405	COG4771	TonB-dependent receptor
GFO_RS05410	COG0702	epimerase
GFO_RS05430	COG2186	Transcriptional regulator
GFO_RS05435	COG2271	Major facilitator Superfamily
GFO_RS05455	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GFO_RS05485	COG0531	amino acid
GFO_RS05540	COG2217	Heavy metal translocating P-type atpase
GFO_RS05560	COG0347	Belongs to the P(II) protein family
GFO_RS05600	COG3781	membrane
GFO_RS05605	COG1285	pathogenesis
GFO_RS05620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFO_RS05625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFO_RS05635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFO_RS05650	COG0531	amino acid
GFO_RS05685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GFO_RS05695	COG0463	Glycosyl transferase, family 2
GFO_RS05700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS05720	COG5002	protein histidine kinase activity
GFO_RS05725	COG0745	RESPONSE REGULATOR receiver
GFO_RS05730	COG0671	phosphoesterase, PA-phosphatase related
GFO_RS05735	COG0629	single-stranded DNA binding
GFO_RS05745	COG4974	Belongs to the 'phage' integrase family
GFO_RS05750	COG4974	Belongs to the 'phage' integrase family
GFO_RS05755	COG4974	Belongs to the 'phage' integrase family
GFO_RS05760	COG2003	Belongs to the UPF0758 family
GFO_RS05805	COG2132	Multicopper oxidase
GFO_RS05825	COG0069	glutamate synthase activity
GFO_RS05855	COG1629	transport
GFO_RS05855	COG4206	TonB-dependent receptor
GFO_RS05865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFO_RS05880	COG1629	transport
GFO_RS05880	COG4206	TonB-dependent receptor
GFO_RS05900	COG0730	response to heat
GFO_RS05905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFO_RS05950	COG0737	Belongs to the 5'-nucleotidase family
GFO_RS05955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFO_RS05980	COG0737	Belongs to the 5'-nucleotidase family
GFO_RS06045	COG2814	Major facilitator Superfamily
GFO_RS06105	COG0723	plastoquinol--plastocyanin reductase activity
GFO_RS06130	COG0582	viral genome integration into host DNA
GFO_RS06180	COG0640	Transcriptional regulator
GFO_RS06185	COG0183	Belongs to the thiolase family
GFO_RS06195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFO_RS06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFO_RS06225	COG0347	Belongs to the P(II) protein family
GFO_RS06230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS06240	COG2132	Multicopper oxidase
GFO_RS06250	COG1999	signal sequence binding
GFO_RS06255	COG2217	Heavy metal translocating P-type atpase
GFO_RS06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFO_RS06280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFO_RS06285	COG0629	single-stranded DNA binding
GFO_RS06295	COG4974	Belongs to the 'phage' integrase family
GFO_RS06300	COG4974	Belongs to the 'phage' integrase family
GFO_RS06305	COG4974	Belongs to the 'phage' integrase family
GFO_RS06380	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFO_RS06400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFO_RS06420	COG0156	8-amino-7-oxononanoate synthase activity
GFO_RS06430	COG2207	Transcriptional regulator
GFO_RS06450	COG4771	TonB-dependent receptor
GFO_RS06480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFO_RS06485	COG3189	MarR family transcriptional regulator
GFO_RS06525	COG1959	2 iron, 2 sulfur cluster binding
GFO_RS06585	COG4263	nitrous-oxide reductase activity
GFO_RS06590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFO_RS06600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFO_RS06605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFO_RS06615	COG0589	response to stress
GFO_RS06630	COG0745	RESPONSE REGULATOR receiver
GFO_RS06650	COG0427	acetyl-CoA hydrolase
GFO_RS06685	COG2217	Heavy metal translocating P-type atpase
GFO_RS06695	COG3278	Belongs to the heme-copper respiratory oxidase family
GFO_RS06710	COG0348	domain, Protein
GFO_RS06735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFO_RS06740	COG1678	Uncharacterized ACR, COG1678
GFO_RS06750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFO_RS06755	COG0514	ATP-dependent DNA helicase (RecQ)
GFO_RS06775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFO_RS06805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFO_RS06815	COG4251	negative regulation of phosphorylation
GFO_RS06840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFO_RS06845	COG0302	gtp cyclohydrolase
GFO_RS06855	COG4771	TonB-dependent receptor
GFO_RS06880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFO_RS06885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFO_RS06895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFO_RS06920	COG1629	transport
GFO_RS06925	COG0012	GTP binding
GFO_RS06945	COG1970	mechanosensitive ion channel activity
GFO_RS06965	COG1522	sequence-specific DNA binding
GFO_RS06970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFO_RS06985	COG0693	protein deglycase activity
GFO_RS06995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFO_RS07010	COG0217	transcriptional regulatory protein
GFO_RS07015	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFO_RS07025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFO_RS07030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFO_RS07030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFO_RS07035	COG2986	histidine ammonia-lyase
GFO_RS07045	COG0542	response to heat
GFO_RS07050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFO_RS07065	COG0183	Belongs to the thiolase family
GFO_RS07070	COG1480	7TM receptor with intracellular HD hydrolase
GFO_RS07095	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS07110	COG1607	acyl-coa hydrolase
GFO_RS07115	COG0668	transmembrane transport
GFO_RS07125	COG0668	transmembrane transport
GFO_RS07130	COG2814	Major facilitator Superfamily
GFO_RS07135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFO_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS07160	COG4221	oxidoreductase activity
GFO_RS07165	COG2130	NADP-dependent
GFO_RS07170	COG1289	transmembrane transporter activity
GFO_RS07180	COG1045	serine acetyltransferase
GFO_RS07210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GFO_RS07225	COG0189	ligase activity
GFO_RS07240	COG1764	response to oxidative stress
GFO_RS07250	COG0673	inositol 2-dehydrogenase activity
GFO_RS07270	COG0527	aspartate kinase activity
GFO_RS07280	COG0471	metal ion transport
GFO_RS07280	COG3273	potassium ion transport
GFO_RS07285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFO_RS07340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFO_RS07365	COG0589	response to stress
GFO_RS07385	COG0604	alcohol dehydrogenase
GFO_RS07390	COG1278	Cold shock
GFO_RS07395	COG3239	Fatty acid desaturase
GFO_RS07400	COG1278	Cold shock
GFO_RS07405	COG1278	Cold shock
GFO_RS07410	COG1278	Cold shock
GFO_RS07420	COG0628	permease
GFO_RS07440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFO_RS07505	COG0590	tRNA wobble adenosine to inosine editing
GFO_RS07515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFO_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFO_RS07545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFO_RS07585	COG0022	dehydrogenase e1 component
GFO_RS07605	COG0813	purine-nucleoside phosphorylase activity
GFO_RS07610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFO_RS07620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFO_RS07625	COG1193	negative regulation of DNA recombination
GFO_RS07630	COG3011	Protein conserved in bacteria
GFO_RS07635	COG1301	dicarboxylic acid transport
GFO_RS07640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFO_RS07645	COG0745	RESPONSE REGULATOR receiver
GFO_RS07655	COG0277	FAD linked oxidase domain protein
GFO_RS07655	COG0247	lactate metabolic process
GFO_RS07665	COG0438	transferase activity, transferring glycosyl groups
GFO_RS07670	COG1472	Belongs to the glycosyl hydrolase 3 family
GFO_RS07680	COG0247	lactate metabolic process
GFO_RS07680	COG2181	nitrate reductase activity
GFO_RS07685	COG0247	lactate metabolic process
GFO_RS07685	COG2181	nitrate reductase activity
GFO_RS07695	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFO_RS07705	COG0251	oxidation-reduction process
GFO_RS07710	COG1803	Methylglyoxal synthase
GFO_RS07715	COG0205	6-phosphofructokinase activity
GFO_RS07725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFO_RS07745	COG0628	permease
GFO_RS07780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFO_RS07790	COG0726	polysaccharide deacetylase
GFO_RS07800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFO_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS07880	COG1917	Cupin 2, conserved barrel domain protein
GFO_RS07880	COG4977	sequence-specific DNA binding
GFO_RS07885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFO_RS07890	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS07890	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS07910	COG0745	RESPONSE REGULATOR receiver
GFO_RS07935	COG0667	Aldo Keto reductase
GFO_RS07940	COG1482	cell wall glycoprotein biosynthetic process
GFO_RS07965	COG3292	Two component regulator propeller
GFO_RS07965	COG2205	protein histidine kinase activity
GFO_RS07965	COG0745	RESPONSE REGULATOR receiver
GFO_RS07970	COG3119	arylsulfatase activity
GFO_RS07975	COG3250	beta-galactosidase activity
GFO_RS07980	COG3254	rhamnose metabolic process
GFO_RS07985	COG0738	Major facilitator superfamily
GFO_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS08000	COG0246	Mannitol dehydrogenase
GFO_RS08005	COG2721	sulfolactate sulfo-lyase activity
GFO_RS08010	COG0800	Aldolase
GFO_RS08020	COG1063	alcohol dehydrogenase
GFO_RS08030	COG4771	TonB-dependent receptor
GFO_RS08035	COG0561	phosphatase activity
GFO_RS08060	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFO_RS08070	COG3250	beta-galactosidase activity
GFO_RS08095	COG3250	beta-galactosidase activity
GFO_RS08100	COG2273	Hydrolase Family 16
GFO_RS08115	COG0702	epimerase
GFO_RS08120	COG4771	TonB-dependent receptor
GFO_RS08135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GFO_RS08135	COG3408	Glycogen debranching enzyme
GFO_RS08140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFO_RS08145	COG3250	beta-galactosidase activity
GFO_RS08150	COG0463	Glycosyl transferase, family 2
GFO_RS08160	COG0189	ligase activity
GFO_RS08165	COG2988	succinylglutamate desuccinylase activity
GFO_RS08175	COG2706	6-phosphogluconolactonase activity
GFO_RS08180	COG0598	Magnesium transport protein CorA
GFO_RS08190	COG0101	tRNA pseudouridine synthase activity
GFO_RS08210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFO_RS08235	COG0140	phosphoribosyl-ATP diphosphatase activity
GFO_RS08235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFO_RS08240	COG0107	imidazoleglycerol-phosphate synthase activity
GFO_RS08245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFO_RS08250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFO_RS08255	COG0131	Imidazoleglycerol-phosphate dehydratase
GFO_RS08260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFO_RS08265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFO_RS08270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFO_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS08290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFO_RS08310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFO_RS08315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFO_RS08320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFO_RS08325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFO_RS08325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GFO_RS08330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFO_RS08335	COG1078	dGTPase activity
GFO_RS08340	COG2204	response regulator
GFO_RS08345	COG0802	atpase or kinase
GFO_RS08365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFO_RS08370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFO_RS08380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFO_RS08415	COG0156	8-amino-7-oxononanoate synthase activity
GFO_RS08430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFO_RS08455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFO_RS08460	COG1393	Belongs to the ArsC family
GFO_RS08490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFO_RS08490	COG1333	cytochrome c biogenesis protein
GFO_RS08510	COG0424	maF-like protein
GFO_RS08535	COG0673	inositol 2-dehydrogenase activity
GFO_RS08555	COG0415	Belongs to the DNA photolyase family
GFO_RS08560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GFO_RS08565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFO_RS08580	COG0742	ribosomal rna small subunit methyltransferase
GFO_RS08595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFO_RS08610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFO_RS08620	COG0259	pyridoxamine-phosphate oxidase activity
GFO_RS08650	COG1234	tRNA 3'-trailer cleavage
GFO_RS08660	COG0540	Belongs to the ATCase OTCase family
GFO_RS08665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFO_RS08690	COG2814	Major facilitator Superfamily
GFO_RS08695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFO_RS08700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFO_RS08725	COG2270	Major facilitator Superfamily
GFO_RS08740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFO_RS08745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFO_RS08755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFO_RS08765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFO_RS08790	COG4974	Belongs to the 'phage' integrase family
GFO_RS08795	COG0656	L-ascorbic acid biosynthetic process
GFO_RS08800	COG1418	mRNA catabolic process
GFO_RS08820	COG1104	cysteine desulfurase activity
GFO_RS08855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFO_RS08860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFO_RS08875	COG0116	Belongs to the methyltransferase superfamily
GFO_RS08930	COG1363	Peptidase, m42
GFO_RS08955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFO_RS08960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFO_RS08965	COG1702	phosphate starvation-inducible protein PhoH
GFO_RS08990	COG0592	DNA-directed DNA polymerase activity
GFO_RS09000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFO_RS09010	COG2323	membrane
GFO_RS09015	COG4221	oxidoreductase activity
GFO_RS09045	COG2207	Transcriptional regulator
GFO_RS09060	COG1846	Transcriptional regulator
GFO_RS09065	COG0604	alcohol dehydrogenase
GFO_RS09105	COG0714	Associated with various cellular activities
GFO_RS09115	COG0312	modulator of DNA gyrase
GFO_RS09120	COG0312	modulator of DNA gyrase
GFO_RS09125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFO_RS09155	COG4181	ATPase activity
GFO_RS09160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GFO_RS09165	COG2207	Transcriptional regulator
GFO_RS09165	COG1917	Cupin 2, conserved barrel domain protein
GFO_RS09170	COG0339	signal peptide processing
GFO_RS09175	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFO_RS09180	COG1187	pseudouridine synthase activity
GFO_RS09185	COG0405	Gamma-glutamyltransferase
GFO_RS09200	COG4251	negative regulation of phosphorylation
GFO_RS09210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFO_RS09215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFO_RS09220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFO_RS09230	COG4651	solute:proton antiporter activity
GFO_RS09230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFO_RS09245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFO_RS09250	COG0083	homoserine kinase activity
GFO_RS09255	COG0460	homoserine dehydrogenase
GFO_RS09255	COG0527	aspartate kinase activity
GFO_RS09265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GFO_RS09300	COG5002	protein histidine kinase activity
GFO_RS09320	COG1596	polysaccharide export
GFO_RS09330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFO_RS09340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFO_RS09360	COG3549	Plasmid maintenance system killer
GFO_RS09385	COG0367	asparagine synthase
GFO_RS09410	COG0297	glycogen (starch) synthase activity
GFO_RS09410	COG0438	transferase activity, transferring glycosyl groups
GFO_RS09415	COG0297	glycogen (starch) synthase activity
GFO_RS09415	COG0438	transferase activity, transferring glycosyl groups
GFO_RS09425	COG1649	PFAM Uncharacterised BCR, COG1649
GFO_RS09425	COG0726	polysaccharide deacetylase
GFO_RS09465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFO_RS09470	COG2089	acid synthase
GFO_RS09480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFO_RS09490	COG2030	dehydratase
GFO_RS09505	COG1083	cytidylyl-transferase
GFO_RS09520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFO_RS09525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFO_RS09530	COG1086	Polysaccharide biosynthesis protein
GFO_RS09580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFO_RS09585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GFO_RS09595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS09600	COG1609	Transcriptional regulator
GFO_RS09615	COG0783	Belongs to the Dps family
GFO_RS09620	COG0668	transmembrane transport
GFO_RS09640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFO_RS09660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFO_RS09705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFO_RS09710	COG1611	Belongs to the LOG family
GFO_RS09720	COG0022	dehydrogenase e1 component
GFO_RS09745	COG2996	Protein conserved in bacteria
GFO_RS09755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFO_RS09790	COG0443	Heat shock 70 kDa protein
GFO_RS09795	COG1760	l-serine dehydratase
GFO_RS09810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFO_RS09815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFO_RS09825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFO_RS09830	COG0564	pseudouridine synthase activity
GFO_RS09835	COG2321	neutral zinc metallopeptidase
GFO_RS09850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFO_RS09855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFO_RS09860	COG0066	3-isopropylmalate dehydratase activity
GFO_RS09870	COG0165	Argininosuccinate lyase
GFO_RS09875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFO_RS09880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFO_RS09895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFO_RS09905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFO_RS09910	COG0137	argininosuccinate synthase activity
GFO_RS09920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFO_RS09925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFO_RS09935	COG0028	Belongs to the TPP enzyme family
GFO_RS09940	COG0129	dihydroxy-acid dehydratase activity
GFO_RS09945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFO_RS09945	COG3153	acetyltransferase
GFO_RS09970	COG1984	allophanate hydrolase subunit 2
GFO_RS09975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GFO_RS09985	COG1914	H( )-stimulated, divalent metal cation uptake system
GFO_RS10000	COG0606	chelatase, subunit chli
GFO_RS10005	COG2205	protein histidine kinase activity
GFO_RS10020	COG0205	6-phosphofructokinase activity
GFO_RS10030	COG0366	Alpha amylase catalytic
GFO_RS10035	COG1554	hydrolase, family 65, central catalytic
GFO_RS10040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFO_RS10055	COG1629	transport
GFO_RS10055	COG4206	TonB-dependent receptor
GFO_RS10060	COG0702	epimerase
GFO_RS10070	COG0366	Alpha amylase catalytic
GFO_RS10095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFO_RS10100	COG1085	galactose-1-phosphate uridylyltransferase
GFO_RS10105	COG1609	Transcriptional regulator
GFO_RS10110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFO_RS10130	COG0037	tRNA processing
GFO_RS10135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFO_RS10150	COG0513	Belongs to the DEAD box helicase family
GFO_RS10175	COG3279	Response regulator of the LytR AlgR family
GFO_RS10180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFO_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS10220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFO_RS10225	COG1522	sequence-specific DNA binding
GFO_RS10235	COG1757	Na H antiporter
GFO_RS10240	COG0450	alkyl hydroperoxide reductase
GFO_RS10265	COG2267	carboxylic ester hydrolase activity
GFO_RS10270	COG1674	ftsk spoiiie
GFO_RS10285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFO_RS10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFO_RS10295	COG2949	membrane
GFO_RS10350	COG0798	PFAM Bile acid sodium symporter
GFO_RS10360	COG2514	catechol 2,3-dioxygenase activity
GFO_RS10430	COG2201	protein-glutamate methylesterase activity
GFO_RS10440	COG0504	CTP synthase activity
GFO_RS10445	COG0706	membrane insertase activity
GFO_RS10460	COG0482	sulfurtransferase activity
GFO_RS10485	COG1388	LysM domain
GFO_RS10485	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFO_RS10490	COG0519	Catalyzes the synthesis of GMP from XMP
GFO_RS10490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFO_RS10505	COG0076	glutamate decarboxylase activity
GFO_RS10510	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GFO_RS10525	COG0612	Peptidase, M16
GFO_RS10530	COG0398	Pfam SNARE associated Golgi protein
GFO_RS10540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFO_RS10550	COG0154	amidase activity
GFO_RS10555	COG0552	protein localization to endoplasmic reticulum
GFO_RS10560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFO_RS10565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFO_RS10570	COG1058	Belongs to the CinA family
GFO_RS10570	COG1546	Belongs to the CinA family
GFO_RS10590	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS10595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFO_RS10600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFO_RS10615	COG0488	(ABC) transporter
GFO_RS10625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFO_RS10630	COG0300	oxidoreductase activity
GFO_RS10645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFO_RS10655	COG3118	belongs to the thioredoxin family
GFO_RS10660	COG0542	response to heat
GFO_RS10685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFO_RS10700	COG0242	peptide deformylase activity
GFO_RS10705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFO_RS10710	COG2171	N-acyltransferase activity
GFO_RS10730	COG1215	transferase activity, transferring glycosyl groups
GFO_RS10740	COG0438	transferase activity, transferring glycosyl groups
GFO_RS10745	COG0009	L-threonylcarbamoyladenylate synthase
GFO_RS10750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFO_RS10750	COG0617	tRNA 3'-terminal CCA addition
GFO_RS10750	COG0517	IMP dehydrogenase activity
GFO_RS10755	COG1612	heme a metabolic process
GFO_RS10800	COG0071	Belongs to the small heat shock protein (HSP20) family
GFO_RS10815	COG0488	(ABC) transporter
GFO_RS10830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFO_RS10860	COG0318	PFAM AMP-dependent synthetase and ligase
GFO_RS10875	COG1266	CAAX protease self-immunity
GFO_RS10880	COG4948	Mandelate Racemase Muconate Lactonizing
GFO_RS10890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFO_RS10895	COG1575	Belongs to the MenA family. Type 1 subfamily
GFO_RS10915	COG1360	Flagellar Motor Protein
GFO_RS10925	COG2267	carboxylic ester hydrolase activity
GFO_RS10930	COG0009	L-threonylcarbamoyladenylate synthase
GFO_RS10955	COG1473	amidohydrolase
GFO_RS10960	COG0069	glutamate synthase activity
GFO_RS10985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFO_RS11005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFO_RS11025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFO_RS11030	COG1506	peptidase
GFO_RS11045	COG0326	Molecular chaperone. Has ATPase activity
GFO_RS11090	COG0561	phosphatase activity
GFO_RS11105	COG2223	nitrite transmembrane transporter activity
GFO_RS11130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFO_RS11140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GFO_RS11145	COG2885	chlorophyll binding
GFO_RS11150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFO_RS11155	COG1115	amino acid carrier protein
GFO_RS11165	COG2318	DinB family
GFO_RS11170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFO_RS11175	COG0085	RNA polymerase activity
GFO_RS11180	COG0222	ribosome binding
GFO_RS11185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFO_RS11190	COG0081	regulation of translation
GFO_RS11195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFO_RS11215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFO_RS11240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFO_RS11245	COG4974	Belongs to the 'phage' integrase family
GFO_RS11250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFO_RS11255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFO_RS11260	COG1960	acyl-CoA dehydrogenase activity
GFO_RS11270	COG1115	amino acid carrier protein
GFO_RS11275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFO_RS11295	COG1115	amino acid carrier protein
GFO_RS11310	COG3876	Protein conserved in bacteria
GFO_RS11335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFO_RS11345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFO_RS11350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFO_RS11695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFO_RS11775	COG1233	COG1233 Phytoene dehydrogenase and related
GFO_RS11795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFO_RS11800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFO_RS11810	COG0714	Associated with various cellular activities
GFO_RS11815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFO_RS11835	COG0516	GMP reductase activity
GFO_RS11835	COG0517	IMP dehydrogenase activity
GFO_RS11875	COG0167	dihydroorotate dehydrogenase activity
GFO_RS11880	COG1629	transport
GFO_RS11885	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFO_RS11895	COG1862	Preprotein translocase
GFO_RS11905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFO_RS11915	COG1132	(ABC) transporter
GFO_RS11930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFO_RS11935	COG0569	domain protein
GFO_RS11940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFO_RS11950	COG0450	alkyl hydroperoxide reductase
GFO_RS11960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFO_RS11975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFO_RS11990	COG2884	Cell division ATP-binding protein ftsE
GFO_RS12005	COG1217	gtp-binding protein TYPA
GFO_RS12020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GFO_RS12040	COG0668	transmembrane transport
GFO_RS12070	COG4452	Inner membrane protein CreD
GFO_RS12095	COG0668	transmembrane transport
GFO_RS12195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFO_RS12220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GFO_RS12280	COG0484	heat shock protein binding
GFO_RS12285	COG1525	nuclease
GFO_RS12290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFO_RS12350	COG4585	Histidine kinase
GFO_RS12370	COG3275	phosphorelay sensor kinase activity
GFO_RS12375	COG3279	Response regulator of the LytR AlgR family
GFO_RS12415	COG4585	Histidine kinase
GFO_RS12420	COG2197	response regulator
GFO_RS12425	COG2255	four-way junction helicase activity
GFO_RS12440	COG1842	Phage shock protein A
GFO_RS12460	COG3279	Response regulator of the LytR AlgR family
GFO_RS12475	COG2354	Protein conserved in bacteria
GFO_RS12480	COG0668	transmembrane transport
GFO_RS12500	COG2304	oxidoreductase activity
GFO_RS12515	COG0513	Belongs to the DEAD box helicase family
GFO_RS12520	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GFO_RS12530	COG1115	amino acid carrier protein
GFO_RS12555	COG0778	Nitroreductase
GFO_RS12560	COG2353	YceI-like domain
GFO_RS12565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFO_RS12570	COG0512	Glutamine amidotransferase of anthranilate synthase
GFO_RS12570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFO_RS12575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFO_RS12580	COG0134	indole-3-glycerol-phosphate synthase activity
GFO_RS12585	COG0135	phosphoribosylanthranilate isomerase activity
GFO_RS12590	COG0133	tryptophan synthase activity
GFO_RS12595	COG0159	tryptophan synthase activity
GFO_RS12605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFO_RS12610	COG3022	response to hydroperoxide
GFO_RS12615	COG5654	RES domain protein
GFO_RS12625	COG0564	pseudouridine synthase activity
GFO_RS12635	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFO_RS12640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFO_RS12665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFO_RS12680	COG0799	negative regulation of ribosome biogenesis
GFO_RS12685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFO_RS12700	COG0688	phosphatidylethanolamine metabolic process
GFO_RS12710	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFO_RS12720	COG1215	transferase activity, transferring glycosyl groups
GFO_RS12730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFO_RS12735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFO_RS12745	COG1663	tetraacyldisaccharide 4'-kinase activity
GFO_RS12750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFO_RS12770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFO_RS12775	COG1902	pentaerythritol trinitrate reductase activity
GFO_RS12790	COG0415	Belongs to the DNA photolyase family
GFO_RS12795	COG3046	protein related to deoxyribodipyrimidine photolyase
GFO_RS12810	COG3844	kynureninase activity
GFO_RS12820	COG0671	phosphoesterase, PA-phosphatase related
GFO_RS12825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFO_RS12855	COG3340	Belongs to the peptidase S51 family
GFO_RS12860	COG2066	Belongs to the glutaminase family
GFO_RS12865	COG0268	Binds directly to 16S ribosomal RNA
GFO_RS12880	COG0442	prolyl-tRNA aminoacylation
GFO_RS12910	COG0302	gtp cyclohydrolase
GFO_RS12915	COG0215	cysteine-tRNA ligase activity
GFO_RS12920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFO_RS12935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFO_RS12940	COG0039	L-malate dehydrogenase activity
GFO_RS12950	COG0187	DNA topoisomerase II activity
GFO_RS12955	COG0367	asparagine synthase
GFO_RS12965	COG0602	queuosine metabolic process
GFO_RS12985	COG1629	transport
GFO_RS12995	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFO_RS13005	COG0433	COG0433 Predicted ATPase
GFO_RS13025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFO_RS13040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFO_RS13045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFO_RS13050	COG0772	Belongs to the SEDS family
GFO_RS13055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFO_RS13060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFO_RS13065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFO_RS13070	COG0768	penicillin binding
GFO_RS13080	COG0275	rRNA processing
GFO_RS13085	COG2001	Belongs to the MraZ family
GFO_RS13090	COG2267	carboxylic ester hydrolase activity
GFO_RS13095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFO_RS13120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFO_RS13130	COG0358	DNA primase activity
GFO_RS13150	COG1187	pseudouridine synthase activity
GFO_RS13165	COG3339	Conserved Protein
GFO_RS13170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFO_RS13180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFO_RS13185	COG0018	arginyl-trna synthetase
GFO_RS13195	COG2095	MarC family integral membrane protein
GFO_RS13205	COG0702	epimerase
GFO_RS13210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GFO_RS13230	COG0297	glycogen (starch) synthase activity
GFO_RS13235	COG0148	phosphopyruvate hydratase activity
GFO_RS13255	COG0203	ribosomal protein L17
GFO_RS13260	COG0202	RNA polymerase activity
GFO_RS13265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFO_RS13270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFO_RS13275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFO_RS13280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFO_RS13290	COG0200	Binds to the 23S rRNA
GFO_RS13295	COG1841	ribosomal large subunit assembly
GFO_RS13300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFO_RS13305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFO_RS13310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFO_RS13315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFO_RS13320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFO_RS13325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFO_RS13330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFO_RS13335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFO_RS13340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFO_RS13345	COG0255	Belongs to the universal ribosomal protein uL29 family
GFO_RS13350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFO_RS13355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFO_RS13360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFO_RS13365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFO_RS13370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFO_RS13375	COG0089	rRNA binding
GFO_RS13380	COG0088	Forms part of the polypeptide exit tunnel
GFO_RS13385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFO_RS13390	COG0051	transcription antitermination factor activity, RNA binding
GFO_RS13395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFO_RS13400	COG0049	tRNA binding
GFO_RS13405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFO_RS13410	COG4771	TonB-dependent receptor
GFO_RS13420	COG4771	TonB-dependent receptor
GFO_RS13435	COG4206	TonB-dependent receptor
GFO_RS13435	COG1629	transport
GFO_RS13445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFO_RS13455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFO_RS13475	COG1011	Hydrolase
GFO_RS13485	COG2003	Belongs to the UPF0758 family
GFO_RS13490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFO_RS13520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFO_RS13525	COG0563	adenylate kinase activity
GFO_RS13530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFO_RS13535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFO_RS13540	COG0339	signal peptide processing
GFO_RS13560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFO_RS13560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFO_RS13565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFO_RS13580	COG1442	glycosyl transferase family 8
GFO_RS13580	COG1216	Glycosyl transferase, family 2
GFO_RS13590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFO_RS13595	COG1127	ABC transporter
GFO_RS13605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GFO_RS13605	COG0662	Cupin 2, conserved barrel domain protein
GFO_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS13625	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS13630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFO_RS13635	COG0295	cytidine deaminase activity
GFO_RS13645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFO_RS13650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFO_RS13685	COG0848	biopolymer transport protein
GFO_RS13690	COG0811	peptide transport
GFO_RS13705	COG1960	acyl-CoA dehydrogenase activity
GFO_RS13720	COG0067	glutamate synthase
GFO_RS13720	COG0070	glutamate synthase
GFO_RS13720	COG0069	glutamate synthase activity
GFO_RS13780	COG0702	epimerase
GFO_RS13785	COG1629	transport
GFO_RS13790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFO_RS13795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFO_RS13800	COG0321	lipoyl(octanoyl) transferase activity
GFO_RS13805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFO_RS13825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFO_RS13830	COG0436	Aminotransferase
GFO_RS13840	COG0525	valine-tRNA ligase activity
GFO_RS13845	COG0701	Predicted permease
GFO_RS13850	COG2217	Heavy metal translocating P-type atpase
GFO_RS13885	COG2132	Multicopper oxidase
GFO_RS13915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFO_RS13925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFO_RS13955	COG0138	bifunctional purine biosynthesis protein purh
GFO_RS13960	COG1077	Cell shape determining protein MreB Mrl
GFO_RS13980	COG0772	Belongs to the SEDS family
GFO_RS13985	COG0793	Belongs to the peptidase S41A family
GFO_RS13990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GFO_RS14005	COG0791	NLP P60 protein
GFO_RS14010	COG0658	competence protein
GFO_RS14010	COG2333	competence protein COMEC
GFO_RS14025	COG3104	oligopeptide transport
GFO_RS14030	COG0823	Involved in the tonB-independent uptake of proteins
GFO_RS14030	COG1506	peptidase
GFO_RS14045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFO_RS14050	COG1253	flavin adenine dinucleotide binding
GFO_RS14070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFO_RS14090	COG1160	GTP binding
GFO_RS14095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFO_RS14100	COG0659	secondary active sulfate transmembrane transporter activity
GFO_RS14125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFO_RS14140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFO_RS14150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFO_RS14190	COG0488	(ABC) transporter
GFO_RS14220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFO_RS14240	COG4221	oxidoreductase activity
GFO_RS14250	COG4232	protein-disulfide reductase activity
GFO_RS14285	COG0228	four-way junction DNA binding
GFO_RS14290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFO_RS14295	COG0495	leucyl-tRNA aminoacylation
GFO_RS14305	COG2177	Part of the ABC transporter FtsEX involved in
GFO_RS14315	COG1968	undecaprenyl-diphosphatase activity
GFO_RS14320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFO_RS14330	COG0519	Catalyzes the synthesis of GMP from XMP
GFO_RS14340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GFO_RS14355	COG3852	Histidine kinase
GFO_RS14370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFO_RS14385	COG0784	Response regulator, receiver
GFO_RS14385	COG2205	protein histidine kinase activity
GFO_RS14400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFO_RS14425	COG0346	lactoylglutathione lyase activity
GFO_RS14430	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GFO_RS14440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFO_RS14480	COG0494	nUDIX hydrolase
GFO_RS14490	COG0587	DNA-directed DNA polymerase activity
GFO_RS14495	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GFO_RS14505	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFO_RS14510	COG0567	Dehydrogenase, E1 component
GFO_RS14520	COG1309	transcriptional regulator
GFO_RS14530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFO_RS14545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFO_RS14565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS14580	COG3590	peptidase
GFO_RS14585	COG0792	nuclease activity
GFO_RS14595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFO_RS14595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFO_RS14600	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFO_RS14605	COG0629	single-stranded DNA binding
GFO_RS14635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFO_RS14660	COG0516	GMP reductase activity
GFO_RS14660	COG0517	IMP dehydrogenase activity
GFO_RS14670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS14695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFO_RS14710	COG2151	metal-sulfur cluster biosynthetic enzyme
GFO_RS14715	COG2166	iron-sulfur cluster assembly
GFO_RS14730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFO_RS14735	COG0719	Fe-S assembly protein
GFO_RS14740	COG0396	ATPase activity
GFO_RS14750	COG0719	Fe-S assembly protein
GFO_RS14760	COG0316	Belongs to the HesB IscA family
GFO_RS14765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFO_RS14790	COG0006	proline dipeptidase activity
GFO_RS14805	COG0484	heat shock protein binding
GFO_RS14820	COG1053	succinate dehydrogenase
GFO_RS14830	COG0436	Aminotransferase
GFO_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS14870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFO_RS14905	COG0166	Belongs to the GPI family
GFO_RS14910	COG0739	heme binding
GFO_RS14910	COG1196	nuclear chromosome segregation
GFO_RS14910	COG0741	lytic transglycosylase activity
GFO_RS14925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GFO_RS14930	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GFO_RS14935	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFO_RS14940	COG0322	excinuclease ABC activity
GFO_RS14945	COG0189	ligase activity
GFO_RS14945	COG4067	protein conserved in archaea
GFO_RS14950	COG0189	ligase activity
GFO_RS14960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFO_RS14970	COG2201	protein-glutamate methylesterase activity
GFO_RS14975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFO_RS14990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFO_RS14995	COG4206	TonB-dependent receptor
GFO_RS15000	COG1381	Involved in DNA repair and RecF pathway recombination
GFO_RS15005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFO_RS15015	COG1335	isochorismatase
GFO_RS15020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFO_RS15040	COG0584	glycerophosphoryl diester phosphodiesterase
GFO_RS15050	COG2192	nodulation
GFO_RS15065	COG0750	zinc metalloprotease
GFO_RS15070	COG1999	signal sequence binding
GFO_RS15100	COG4771	TonB-dependent receptor
GFO_RS15125	COG1418	mRNA catabolic process
GFO_RS15135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFO_RS15140	COG0535	radical SAM domain protein
GFO_RS15145	COG1024	Enoyl-CoA hydratase
GFO_RS15155	COG1981	membrane
GFO_RS15170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFO_RS15185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFO_RS15200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFO_RS15210	COG0408	coproporphyrinogen oxidase activity
GFO_RS15220	COG0113	porphobilinogen synthase activity
GFO_RS15235	COG1253	flavin adenine dinucleotide binding
GFO_RS15240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFO_RS15270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GFO_RS15275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GFO_RS15285	COG1774	PSP1 C-terminal conserved region
GFO_RS15290	COG1054	Belongs to the UPF0176 family
GFO_RS15295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFO_RS15325	COG0758	DNA mediated transformation
GFO_RS15325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFO_RS15335	COG1607	acyl-coa hydrolase
GFO_RS15365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFO_RS15375	COG0756	dUTP diphosphatase activity
GFO_RS15390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFO_RS15395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFO_RS15400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFO_RS15405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFO_RS15410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFO_RS15415	COG0356	it plays a direct role in the translocation of protons across the membrane
GFO_RS15485	COG1215	transferase activity, transferring glycosyl groups
GFO_RS15490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFO_RS15495	COG1091	dTDP-4-dehydrorhamnose reductase activity
GFO_RS15520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFO_RS15530	COG1388	LysM domain
GFO_RS15530	COG3942	CHAP domain
GFO_RS15535	COG0126	phosphoglycerate kinase activity
GFO_RS15540	COG0470	DNA polymerase III
GFO_RS15560	COG0445	tRNA wobble uridine modification
GFO_RS15565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFO_RS15575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFO_RS15600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFO_RS15625	COG0557	exoribonuclease II activity
GFO_RS15630	COG0698	ribose 5-phosphate isomerase
GFO_RS15635	COG2153	protein acetylation
GFO_RS15645	COG0793	Belongs to the peptidase S41A family
GFO_RS15650	COG0594	ribonuclease P activity
GFO_RS15665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFO_RS15670	COG3263	regulation of cellular component size
GFO_RS15675	COG0217	transcriptional regulatory protein
GFO_RS15685	COG0481	GTPase activity
GFO_RS15695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFO_RS15700	COG1649	PFAM Uncharacterised BCR, COG1649
GFO_RS15705	COG4948	Mandelate Racemase Muconate Lactonizing
GFO_RS15725	COG4591	ABC-type transport system involved in lipoprotein release permease component
GFO_RS15730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFO_RS15735	COG0346	lactoylglutathione lyase activity
GFO_RS15755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GFO_RS15765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFO_RS15770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFO_RS15775	COG0511	ligase activity, forming carbon-carbon bonds
GFO_RS15780	COG0439	Biotin carboxylase
GFO_RS15790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFO_RS15805	COG1505	serine-type exopeptidase activity
GFO_RS15810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFO_RS15815	COG1970	mechanosensitive ion channel activity
GFO_RS15820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFO_RS15825	COG1435	thymidine kinase activity
GFO_RS15835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFO_RS15840	COG1573	uracil-dna glycosylase
GFO_RS15850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFO_RS15850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFO_RS15855	COG2161	toxin-antitoxin pair type II binding
GFO_RS15860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFO_RS15865	COG0720	synthase
GFO_RS15880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFO_RS15905	COG0210	DNA helicase
GFO_RS15910	COG2885	chlorophyll binding
GFO_RS15915	COG0156	8-amino-7-oxononanoate synthase activity
GFO_RS15920	COG1074	ATP-dependent DNA helicase activity
GFO_RS15930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFO_RS15940	COG0328	RNA-DNA hybrid ribonuclease activity
GFO_RS15950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFO_RS15955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFO_RS15960	COG0571	ribonuclease III activity
GFO_RS15980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFO_RS15985	COG0702	epimerase
GFO_RS15990	COG2954	triphosphatase activity
GFO_RS16015	COG1538	Outer membrane efflux protein
GFO_RS16025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFO_RS16035	COG1446	asparaginase
GFO_RS16045	COG1012	belongs to the aldehyde dehydrogenase family
GFO_RS16050	COG3339	Conserved Protein
GFO_RS16075	COG4221	oxidoreductase activity
GFO_RS16085	COG0714	Associated with various cellular activities
GFO_RS16100	COG2304	oxidoreductase activity
GFO_RS16105	COG2304	oxidoreductase activity
GFO_RS16155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFO_RS16175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFO_RS16180	COG1652	LysM domain
GFO_RS16185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFO_RS16190	COG0194	GDP metabolic process
GFO_RS16195	COG1561	YicC-like family, N-terminal region
GFO_RS16200	COG0429	hydrolase of the alpha beta-hydrolase fold
GFO_RS16245	COG0626	cystathionine gamma-synthase activity
GFO_RS16250	COG1082	Xylose isomerase domain protein TIM barrel
GFO_RS16255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFO_RS16345	COG4771	TonB-dependent receptor
GFO_RS16350	COG0702	epimerase
GFO_RS16375	COG0590	tRNA wobble adenosine to inosine editing
GFO_RS16380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFO_RS16390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFO_RS16405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFO_RS16405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFO_RS16425	COG2095	MarC family integral membrane protein
GFO_RS16445	COG0793	Belongs to the peptidase S41A family
GFO_RS16445	COG3409	Peptidoglycan-binding domain 1 protein
GFO_RS16475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFO_RS16505	COG2226	methyltransferase
GFO_RS16510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFO_RS16520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFO_RS16525	COG0193	aminoacyl-tRNA hydrolase activity
GFO_RS16530	COG0196	riboflavin kinase activity
GFO_RS16540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFO_RS16555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFO_RS16560	COG2239	Acts as a magnesium transporter
GFO_RS16565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFO_RS16575	COG0346	lactoylglutathione lyase activity
GFO_RS16580	COG0702	epimerase
GFO_RS16590	COG0527	aspartate kinase activity
GFO_RS16605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GFO_RS16615	COG1793	dna ligase
GFO_RS16615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GFO_RS16620	COG1793	dna ligase
GFO_RS16635	COG1201	RNA secondary structure unwinding
GFO_RS16645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFO_RS16655	COG1040	competence protein
GFO_RS16665	COG0423	glycine-tRNA ligase activity
GFO_RS16675	COG0708	Exodeoxyribonuclease III
GFO_RS16685	COG0667	Aldo Keto reductase
GFO_RS16695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFO_RS16710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFO_RS16715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFO_RS16720	COG0297	glycogen (starch) synthase activity
GFO_RS16730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFO_RS16735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFO_RS16740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFO_RS16745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFO_RS16750	COG3655	Transcriptional regulator
GFO_RS16760	COG2111	Na H antiporter
GFO_RS16760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFO_RS16770	COG1006	Multisubunit Na H antiporter MnhC subunit
GFO_RS16775	COG0651	ATP synthesis coupled electron transport
GFO_RS16780	COG1863	multisubunit Na H antiporter MnhE subunit
GFO_RS16785	COG2212	antiporter activity
GFO_RS16790	COG1320	monovalent cation:proton antiporter activity
GFO_RS16805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GFO_RS16810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFO_RS16820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFO_RS16825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFO_RS16840	COG2137	regulation of response to DNA damage stimulus
GFO_RS16850	COG3685	Protein conserved in bacteria
GFO_RS16855	COG1530	ribonuclease E activity
GFO_RS16860	COG0776	regulation of translation
GFO_RS16885	COG4771	TonB-dependent receptor
GFO_RS16905	COG0612	Peptidase, M16
GFO_RS16915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFO_RS16920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFO_RS16935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFO_RS16940	COG3604	Transcriptional regulator
GFO_RS16960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFO_RS16965	COG0459	protein refolding
GFO_RS16975	COG0471	metal ion transport
GFO_RS17005	COG4206	TonB-dependent receptor
GFO_RS17005	COG1629	transport
GFO_RS17035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFO_RS17040	COG2226	methyltransferase
GFO_RS17050	COG0463	Glycosyl transferase, family 2
GFO_RS17065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFO_RS17080	COG1215	transferase activity, transferring glycosyl groups
GFO_RS17105	COG0010	Belongs to the arginase family
GFO_RS17115	COG1187	pseudouridine synthase activity
GFO_RS17150	COG2081	HI0933 family
GFO_RS17155	COG0584	glycerophosphoryl diester phosphodiesterase
GFO_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS17165	COG2323	membrane
GFO_RS17190	COG3547	Transposase (IS116 IS110 IS902 family)
GFO_RS17215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFO_RS17220	COG2732	(Barnase) inhibitor
GFO_RS17230	COG1609	Transcriptional regulator
GFO_RS17260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFO_RS17265	COG1247	-acetyltransferase
GFO_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
GFO_RS17285	COG1215	transferase activity, transferring glycosyl groups
GFO_RS17350	COG0484	heat shock protein binding
GFO_RS17355	COG3920	Histidine kinase