locus-tag	class	description
C7S20_RS00075	COG2234	aminopeptidase activity
C7S20_RS00080	COG0488	(ABC) transporter
C7S20_RS00090	COG0463	Glycosyl transferase, family 2
C7S20_RS00095	COG1136	(ABC) transporter
C7S20_RS00105	COG0514	ATP-dependent DNA helicase (RecQ)
C7S20_RS00110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7S20_RS00110	COG0517	IMP dehydrogenase activity
C7S20_RS00115	COG0805	protein transport
C7S20_RS00125	COG1137	ATPase activity
C7S20_RS00140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C7S20_RS00145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7S20_RS00170	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS00195	COG2226	methyltransferase
C7S20_RS00200	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS00230	COG0367	asparagine synthase
C7S20_RS00235	COG1083	cytidylyl-transferase
C7S20_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7S20_RS00250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7S20_RS00275	COG2089	acid synthase
C7S20_RS00295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7S20_RS00300	COG0463	Glycosyl transferase, family 2
C7S20_RS00320	COG1216	Glycosyl transferase, family 2
C7S20_RS00330	COG0463	Glycosyl transferase, family 2
C7S20_RS00340	COG1216	Glycosyl transferase, family 2
C7S20_RS00340	COG0463	Glycosyl transferase, family 2
C7S20_RS00345	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS00350	COG2226	methyltransferase
C7S20_RS00385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S20_RS00415	COG3206	protein involved in exopolysaccharide biosynthesis
C7S20_RS00415	COG0489	protein tyrosine kinase activity
C7S20_RS00425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S20_RS00435	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S20_RS00445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7S20_RS00455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7S20_RS00475	COG0237	dephospho-CoA kinase activity
C7S20_RS00485	COG0463	Glycosyl transferase, family 2
C7S20_RS00490	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7S20_RS00495	COG0497	DNA recombination
C7S20_RS00520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7S20_RS00535	COG0737	Belongs to the 5'-nucleotidase family
C7S20_RS00540	COG0737	Belongs to the 5'-nucleotidase family
C7S20_RS00545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7S20_RS00560	COG2890	protein-(glutamine-N5) methyltransferase activity
C7S20_RS00570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S20_RS00570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S20_RS00580	COG0697	spore germination
C7S20_RS00585	COG1739	Uncharacterized protein family UPF0029
C7S20_RS00590	COG0824	Thioesterase
C7S20_RS00595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7S20_RS00600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7S20_RS00605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7S20_RS00615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7S20_RS00625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7S20_RS00645	COG0336	Belongs to the RNA methyltransferase TrmD family
C7S20_RS00650	COG0335	large ribosomal subunit rRNA binding
C7S20_RS00660	COG1216	Glycosyl transferase, family 2
C7S20_RS00715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7S20_RS00720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7S20_RS00725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7S20_RS00730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7S20_RS00735	COG0432	Pfam Uncharacterised protein family UPF0047
C7S20_RS00745	COG0305	Participates in initiation and elongation during chromosome replication
C7S20_RS00750	COG0825	malonyl-CoA metabolic process
C7S20_RS00760	COG0343	queuine tRNA-ribosyltransferase activity
C7S20_RS00770	COG3958	Transketolase
C7S20_RS00795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7S20_RS00800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7S20_RS00825	COG0789	Transcriptional regulator
C7S20_RS00830	COG1233	COG1233 Phytoene dehydrogenase and related
C7S20_RS00880	COG3328	transposase activity
C7S20_RS00885	COG0714	Associated with various cellular activities
C7S20_RS00890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S20_RS00905	COG0516	GMP reductase activity
C7S20_RS00905	COG0517	IMP dehydrogenase activity
C7S20_RS00955	COG4772	TonB-dependent receptor
C7S20_RS00970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7S20_RS00980	COG0167	dihydroorotate dehydrogenase activity
C7S20_RS00985	COG4771	TonB-dependent receptor
C7S20_RS00990	COG0405	Gamma-glutamyltransferase
C7S20_RS00995	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7S20_RS01005	COG1862	Preprotein translocase
C7S20_RS01015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S20_RS01025	COG1132	(ABC) transporter
C7S20_RS01040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7S20_RS01045	COG0569	domain protein
C7S20_RS01050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S20_RS01055	COG0450	alkyl hydroperoxide reductase
C7S20_RS01060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S20_RS01095	COG2884	Cell division ATP-binding protein ftsE
C7S20_RS01115	COG1217	gtp-binding protein TYPA
C7S20_RS01125	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C7S20_RS01130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S20_RS01195	COG3250	beta-galactosidase activity
C7S20_RS01200	COG1501	Belongs to the glycosyl hydrolase 31 family
C7S20_RS01205	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS01210	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS01220	COG1295	ribonuclease BN
C7S20_RS01230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S20_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS01250	COG0069	glutamate synthase activity
C7S20_RS01255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7S20_RS01255	COG2755	lipolytic protein G-D-S-L family
C7S20_RS01260	COG1309	transcriptional regulator
C7S20_RS01285	COG1404	Belongs to the peptidase S8 family
C7S20_RS01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S20_RS01300	COG0778	Nitroreductase
C7S20_RS01305	COG2353	YceI-like domain
C7S20_RS01310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7S20_RS01315	COG0512	Glutamine amidotransferase of anthranilate synthase
C7S20_RS01315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7S20_RS01320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7S20_RS01325	COG0134	indole-3-glycerol-phosphate synthase activity
C7S20_RS01330	COG0135	phosphoribosylanthranilate isomerase activity
C7S20_RS01335	COG0133	tryptophan synthase activity
C7S20_RS01340	COG0159	tryptophan synthase activity
C7S20_RS01355	COG3022	response to hydroperoxide
C7S20_RS01370	COG1733	regulation of RNA biosynthetic process
C7S20_RS01390	COG0564	pseudouridine synthase activity
C7S20_RS01400	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7S20_RS01405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7S20_RS01410	COG4771	TonB-dependent receptor
C7S20_RS01425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7S20_RS01440	COG0799	negative regulation of ribosome biogenesis
C7S20_RS01445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S20_RS01460	COG0688	phosphatidylethanolamine metabolic process
C7S20_RS01470	COG0525	valine-tRNA ligase activity
C7S20_RS01485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7S20_RS01490	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS01500	COG1215	transferase activity, transferring glycosyl groups
C7S20_RS01510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7S20_RS01515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7S20_RS01525	COG1663	tetraacyldisaccharide 4'-kinase activity
C7S20_RS01530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7S20_RS01545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S20_RS01550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S20_RS01555	COG1902	pentaerythritol trinitrate reductase activity
C7S20_RS01580	COG3844	kynureninase activity
C7S20_RS01590	COG0671	phosphoesterase, PA-phosphatase related
C7S20_RS01595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7S20_RS01610	COG1629	transport
C7S20_RS01610	COG4206	TonB-dependent receptor
C7S20_RS01615	COG3340	Belongs to the peptidase S51 family
C7S20_RS01620	COG2066	Belongs to the glutaminase family
C7S20_RS01625	COG0268	Binds directly to 16S ribosomal RNA
C7S20_RS01640	COG0442	prolyl-tRNA aminoacylation
C7S20_RS01660	COG0302	gtp cyclohydrolase
C7S20_RS01665	COG0215	cysteine-tRNA ligase activity
C7S20_RS01670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7S20_RS01675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7S20_RS01685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7S20_RS01690	COG0039	L-malate dehydrogenase activity
C7S20_RS01700	COG0187	DNA topoisomerase II activity
C7S20_RS01705	COG0367	asparagine synthase
C7S20_RS01715	COG0602	queuosine metabolic process
C7S20_RS01735	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7S20_RS01745	COG0433	COG0433 Predicted ATPase
C7S20_RS01760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C7S20_RS01775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S20_RS01780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7S20_RS01785	COG0772	Belongs to the SEDS family
C7S20_RS01790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7S20_RS01795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7S20_RS01800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7S20_RS01805	COG0768	penicillin binding
C7S20_RS01815	COG0275	rRNA processing
C7S20_RS01820	COG2001	Belongs to the MraZ family
C7S20_RS01825	COG2267	carboxylic ester hydrolase activity
C7S20_RS01830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7S20_RS01850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7S20_RS01860	COG0358	DNA primase activity
C7S20_RS01880	COG1187	pseudouridine synthase activity
C7S20_RS01900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7S20_RS01910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7S20_RS01915	COG0018	arginyl-trna synthetase
C7S20_RS01930	COG1090	epimerase
C7S20_RS01935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C7S20_RS01945	COG2235	arginine
C7S20_RS01955	COG0297	glycogen (starch) synthase activity
C7S20_RS01960	COG0148	phosphopyruvate hydratase activity
C7S20_RS01975	COG0505	Belongs to the CarA family
C7S20_RS01980	COG0203	ribosomal protein L17
C7S20_RS01985	COG0202	RNA polymerase activity
C7S20_RS01990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7S20_RS01995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7S20_RS02000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7S20_RS02005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7S20_RS02010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7S20_RS02020	COG0200	Binds to the 23S rRNA
C7S20_RS02025	COG1841	ribosomal large subunit assembly
C7S20_RS02030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7S20_RS02040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7S20_RS02045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7S20_RS02050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7S20_RS02055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7S20_RS02060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7S20_RS02065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7S20_RS02070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7S20_RS02075	COG0255	Belongs to the universal ribosomal protein uL29 family
C7S20_RS02080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7S20_RS02085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7S20_RS02090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7S20_RS02095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7S20_RS02100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7S20_RS02105	COG0089	rRNA binding
C7S20_RS02110	COG0088	Forms part of the polypeptide exit tunnel
C7S20_RS02115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7S20_RS02120	COG0051	transcription antitermination factor activity, RNA binding
C7S20_RS02125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S20_RS02130	COG0049	tRNA binding
C7S20_RS02135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7S20_RS02140	COG1629	transport
C7S20_RS02170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7S20_RS02190	COG1011	Hydrolase
C7S20_RS02200	COG2003	Belongs to the UPF0758 family
C7S20_RS02205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S20_RS02235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7S20_RS02240	COG0563	adenylate kinase activity
C7S20_RS02245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7S20_RS02250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7S20_RS02255	COG0339	signal peptide processing
C7S20_RS02275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S20_RS02275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S20_RS02280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S20_RS02295	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
C7S20_RS02300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S20_RS02305	COG1127	ABC transporter
C7S20_RS02310	COG0662	Cupin 2, conserved barrel domain protein
C7S20_RS02310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C7S20_RS02330	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS02335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7S20_RS02340	COG0295	cytidine deaminase activity
C7S20_RS02350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7S20_RS02355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7S20_RS02360	COG1082	Xylose isomerase domain protein TIM barrel
C7S20_RS02445	COG4772	TonB-dependent receptor
C7S20_RS02460	COG0629	single-stranded DNA binding
C7S20_RS02465	COG2003	Belongs to the UPF0758 family
C7S20_RS02605	COG0702	epimerase
C7S20_RS02610	COG1629	transport
C7S20_RS02635	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C7S20_RS02640	COG1518	maintenance of DNA repeat elements
C7S20_RS02645	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C7S20_RS02645	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C7S20_RS02670	COG3177	Filamentation induced by cAMP protein fic
C7S20_RS02685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7S20_RS02690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7S20_RS02720	COG0285	dihydrofolate synthase activity
C7S20_RS02730	COG0848	biopolymer transport protein
C7S20_RS02735	COG0811	peptide transport
C7S20_RS02740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C7S20_RS02750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C7S20_RS02755	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS02765	COG0067	glutamate synthase
C7S20_RS02765	COG0069	glutamate synthase activity
C7S20_RS02765	COG0070	glutamate synthase
C7S20_RS02820	COG1629	transport
C7S20_RS02825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7S20_RS02840	COG4771	TonB-dependent receptor
C7S20_RS02845	COG0321	lipoyl(octanoyl) transferase activity
C7S20_RS02850	COG0401	homolog of Blt101
C7S20_RS02855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7S20_RS02875	COG2217	Heavy metal translocating P-type atpase
C7S20_RS02905	COG0701	Predicted permease
C7S20_RS02915	COG2132	Multicopper oxidase
C7S20_RS02920	COG0347	Belongs to the P(II) protein family
C7S20_RS02945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S20_RS02995	COG0138	bifunctional purine biosynthesis protein purh
C7S20_RS03000	COG1077	Cell shape determining protein MreB Mrl
C7S20_RS03015	COG0768	penicillin binding
C7S20_RS03020	COG0772	Belongs to the SEDS family
C7S20_RS03025	COG0793	Belongs to the peptidase S41A family
C7S20_RS03030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C7S20_RS03045	COG0791	NLP P60 protein
C7S20_RS03050	COG2333	competence protein COMEC
C7S20_RS03050	COG0658	competence protein
C7S20_RS03065	COG3104	oligopeptide transport
C7S20_RS03080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S20_RS03085	COG1253	flavin adenine dinucleotide binding
C7S20_RS03100	COG0457	Tetratricopeptide repeat
C7S20_RS03110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C7S20_RS03120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS03125	COG0584	glycerophosphoryl diester phosphodiesterase
C7S20_RS03130	COG1082	Xylose isomerase domain protein TIM barrel
C7S20_RS03135	COG2197	response regulator
C7S20_RS03145	COG1160	GTP binding
C7S20_RS03150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7S20_RS03155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7S20_RS03160	COG0659	secondary active sulfate transmembrane transporter activity
C7S20_RS03185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7S20_RS03190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7S20_RS03195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7S20_RS03200	COG1349	DNA-binding transcription factor activity
C7S20_RS03205	COG0366	Alpha amylase catalytic
C7S20_RS03210	COG3281	Trehalose synthase
C7S20_RS03215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7S20_RS03225	COG3292	Two component regulator propeller
C7S20_RS03225	COG2205	protein histidine kinase activity
C7S20_RS03225	COG0745	RESPONSE REGULATOR receiver
C7S20_RS03225	COG3292	Two component regulator propeller
C7S20_RS03225	COG2205	protein histidine kinase activity
C7S20_RS03225	COG0745	RESPONSE REGULATOR receiver
C7S20_RS03240	COG0348	domain, Protein
C7S20_RS03245	COG2010	Cytochrome c
C7S20_RS03255	COG3278	Belongs to the heme-copper respiratory oxidase family
C7S20_RS03265	COG2217	Heavy metal translocating P-type atpase
C7S20_RS03280	COG5002	protein histidine kinase activity
C7S20_RS03290	COG0589	response to stress
C7S20_RS03300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7S20_RS03310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS03340	COG1131	(ABC) transporter
C7S20_RS03365	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C7S20_RS03370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S20_RS03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS03410	COG1715	Restriction endonuclease
C7S20_RS03425	COG0668	transmembrane transport
C7S20_RS03430	COG2239	Acts as a magnesium transporter
C7S20_RS03450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7S20_RS03460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7S20_RS03460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7S20_RS03460	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7S20_RS03460	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7S20_RS03465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7S20_RS03470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7S20_RS03470	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7S20_RS03475	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7S20_RS03480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS03485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS03490	COG0649	NAD binding
C7S20_RS03495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS03495	COG0649	NAD binding
C7S20_RS03500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7S20_RS03510	COG0839	Belongs to the complex I subunit 6 family
C7S20_RS03515	COG0713	ATP synthesis coupled electron transport
C7S20_RS03520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7S20_RS03525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS03530	COG1007	ATP synthesis coupled electron transport
C7S20_RS03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7S20_RS03595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7S20_RS03605	COG0857	belongs to the CobB CobQ family
C7S20_RS03605	COG0280	phosphate acetyltransferase
C7S20_RS03610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7S20_RS03645	COG0488	(ABC) transporter
C7S20_RS03675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7S20_RS03685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7S20_RS03685	COG1754	DNA topoisomerase type I activity
C7S20_RS03695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7S20_RS03715	COG0356	it plays a direct role in the translocation of protons across the membrane
C7S20_RS03725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7S20_RS03730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7S20_RS03735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7S20_RS03740	COG4221	oxidoreductase activity
C7S20_RS03765	COG0745	RESPONSE REGULATOR receiver
C7S20_RS03785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S20_RS03815	COG0861	Integral membrane protein TerC family
C7S20_RS03820	COG3665	Urea carboxylase-associated protein
C7S20_RS03825	COG3285	dna ligase
C7S20_RS03825	COG1793	dna ligase
C7S20_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS03860	COG0584	glycerophosphoryl diester phosphodiesterase
C7S20_RS03865	COG2081	HI0933 family
C7S20_RS03890	COG1187	pseudouridine synthase activity
C7S20_RS03900	COG0010	Belongs to the arginase family
C7S20_RS03905	COG1899	peptidyl-lysine modification to peptidyl-hypusine
C7S20_RS03915	COG1215	transferase activity, transferring glycosyl groups
C7S20_RS03930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7S20_RS03950	COG2226	methyltransferase
C7S20_RS03955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7S20_RS03980	COG0471	metal ion transport
C7S20_RS03995	COG0459	protein refolding
C7S20_RS04000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7S20_RS04025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7S20_RS04040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7S20_RS04045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7S20_RS04055	COG0612	Peptidase, M16
C7S20_RS04080	COG0629	single-stranded DNA binding
C7S20_RS04085	COG1194	a g-specific adenine glycosylase
C7S20_RS04095	COG1530	ribonuclease E activity
C7S20_RS04115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7S20_RS04130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7S20_RS04135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7S20_RS04150	COG1320	monovalent cation:proton antiporter activity
C7S20_RS04155	COG2212	antiporter activity
C7S20_RS04160	COG1863	multisubunit Na H antiporter MnhE subunit
C7S20_RS04165	COG0651	ATP synthesis coupled electron transport
C7S20_RS04170	COG1006	Multisubunit Na H antiporter MnhC subunit
C7S20_RS04175	COG2111	Na H antiporter
C7S20_RS04180	COG2111	Na H antiporter
C7S20_RS04180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7S20_RS04195	COG3655	Transcriptional regulator
C7S20_RS04200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S20_RS04210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7S20_RS04220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S20_RS04230	COG0297	glycogen (starch) synthase activity
C7S20_RS04235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7S20_RS04240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C7S20_RS04255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C7S20_RS04265	COG0667	Aldo Keto reductase
C7S20_RS04275	COG0708	Exodeoxyribonuclease III
C7S20_RS04285	COG0423	glycine-tRNA ligase activity
C7S20_RS04295	COG1040	competence protein
C7S20_RS04315	COG1201	RNA secondary structure unwinding
C7S20_RS04325	COG1793	dna ligase
C7S20_RS04340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C7S20_RS04355	COG0527	aspartate kinase activity
C7S20_RS04365	COG0702	epimerase
C7S20_RS04370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7S20_RS04375	COG2239	Acts as a magnesium transporter
C7S20_RS04380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7S20_RS04395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7S20_RS04410	COG0196	riboflavin kinase activity
C7S20_RS04415	COG0193	aminoacyl-tRNA hydrolase activity
C7S20_RS04420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7S20_RS04430	COG0248	Ppx GppA phosphatase
C7S20_RS04435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7S20_RS04440	COG0667	Aldo Keto reductase
C7S20_RS04465	COG0586	Pfam SNARE associated Golgi protein
C7S20_RS04485	COG4974	Belongs to the 'phage' integrase family
C7S20_RS04555	COG2942	2-epimerase
C7S20_RS04560	COG3345	alpha-galactosidase
C7S20_RS04565	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS04575	COG0561	phosphatase activity
C7S20_RS04580	COG4771	TonB-dependent receptor
C7S20_RS04585	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C7S20_RS04605	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C7S20_RS04610	COG2942	2-epimerase
C7S20_RS04665	COG2197	response regulator
C7S20_RS04700	COG0793	Belongs to the peptidase S41A family
C7S20_RS04710	COG0492	ferredoxin-NADP+ reductase activity
C7S20_RS04720	COG2095	MarC family integral membrane protein
C7S20_RS04735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7S20_RS04735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7S20_RS04740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C7S20_RS04750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7S20_RS04755	COG0590	tRNA wobble adenosine to inosine editing
C7S20_RS04770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C7S20_RS04790	COG4771	TonB-dependent receptor
C7S20_RS04835	COG1999	signal sequence binding
C7S20_RS04850	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS04865	COG2115	Belongs to the xylose isomerase family
C7S20_RS04905	COG0626	cystathionine gamma-synthase activity
C7S20_RS04935	COG0429	hydrolase of the alpha beta-hydrolase fold
C7S20_RS04940	COG1561	YicC-like family, N-terminal region
C7S20_RS04945	COG0194	GDP metabolic process
C7S20_RS04950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7S20_RS04955	COG1652	LysM domain
C7S20_RS04960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7S20_RS04975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7S20_RS05010	COG2304	oxidoreductase activity
C7S20_RS05030	COG0714	Associated with various cellular activities
C7S20_RS05040	COG4221	oxidoreductase activity
C7S20_RS05055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7S20_RS05070	COG3339	Conserved Protein
C7S20_RS05095	COG1012	belongs to the aldehyde dehydrogenase family
C7S20_RS05105	COG1446	asparaginase
C7S20_RS05115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S20_RS05130	COG3118	belongs to the thioredoxin family
C7S20_RS05135	COG2954	triphosphatase activity
C7S20_RS05145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7S20_RS05150	COG0469	pyruvate kinase activity
C7S20_RS05160	COG0571	ribonuclease III activity
C7S20_RS05165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S20_RS05170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S20_RS05175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7S20_RS05180	COG0328	RNA-DNA hybrid ribonuclease activity
C7S20_RS05200	COG1074	ATP-dependent DNA helicase activity
C7S20_RS05205	COG0156	8-amino-7-oxononanoate synthase activity
C7S20_RS05270	COG0720	synthase
C7S20_RS05275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S20_RS05285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7S20_RS05285	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7S20_RS05300	COG1573	uracil-dna glycosylase
C7S20_RS05305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7S20_RS05315	COG1435	thymidine kinase activity
C7S20_RS05320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7S20_RS05325	COG1970	mechanosensitive ion channel activity
C7S20_RS05330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7S20_RS05335	COG1505	serine-type exopeptidase activity
C7S20_RS05355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7S20_RS05365	COG0439	Biotin carboxylase
C7S20_RS05370	COG0511	ligase activity, forming carbon-carbon bonds
C7S20_RS05375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S20_RS05380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7S20_RS05390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7S20_RS05610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S20_RS05680	COG4974	Belongs to the 'phage' integrase family
C7S20_RS05720	COG3177	Filamentation induced by cAMP protein fic
C7S20_RS05755	COG0346	lactoylglutathione lyase activity
C7S20_RS05760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7S20_RS05765	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7S20_RS05780	COG0791	NLP P60 protein
C7S20_RS05785	COG2273	Hydrolase Family 16
C7S20_RS05785	COG5297	Belongs to the glycosyl hydrolase family 6
C7S20_RS05790	COG1649	PFAM Uncharacterised BCR, COG1649
C7S20_RS05800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7S20_RS05805	COG0481	GTPase activity
C7S20_RS05815	COG0217	transcriptional regulatory protein
C7S20_RS05820	COG3263	regulation of cellular component size
C7S20_RS05825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S20_RS05840	COG0594	ribonuclease P activity
C7S20_RS05845	COG0793	Belongs to the peptidase S41A family
C7S20_RS05855	COG2153	protein acetylation
C7S20_RS05860	COG0698	ribose 5-phosphate isomerase
C7S20_RS05870	COG0557	exoribonuclease II activity
C7S20_RS05890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7S20_RS05910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7S20_RS05920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7S20_RS05925	COG0445	tRNA wobble uridine modification
C7S20_RS05945	COG0470	DNA polymerase III
C7S20_RS05950	COG0126	phosphoglycerate kinase activity
C7S20_RS05955	COG1388	LysM domain
C7S20_RS05955	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7S20_RS05965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7S20_RS05970	COG4942	peptidase
C7S20_RS05970	COG1388	LysM domain
C7S20_RS05990	COG1091	dTDP-4-dehydrorhamnose reductase activity
C7S20_RS05995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S20_RS06000	COG1215	transferase activity, transferring glycosyl groups
C7S20_RS06010	COG0151	Belongs to the GarS family
C7S20_RS06070	COG0356	it plays a direct role in the translocation of protons across the membrane
C7S20_RS06075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7S20_RS06080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7S20_RS06085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7S20_RS06090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7S20_RS06095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7S20_RS06110	COG0756	dUTP diphosphatase activity
C7S20_RS06135	COG1607	acyl-coa hydrolase
C7S20_RS06145	COG0758	DNA mediated transformation
C7S20_RS06145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7S20_RS06150	COG0180	Tryptophanyl-tRNA synthetase
C7S20_RS06175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7S20_RS06180	COG0826	peptidase U32
C7S20_RS06190	COG1054	Belongs to the UPF0176 family
C7S20_RS06195	COG1774	PSP1 C-terminal conserved region
C7S20_RS06205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7S20_RS06210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C7S20_RS06235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7S20_RS06240	COG1253	flavin adenine dinucleotide binding
C7S20_RS06255	COG0113	porphobilinogen synthase activity
C7S20_RS06265	COG0408	coproporphyrinogen oxidase activity
C7S20_RS06275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7S20_RS06285	COG0181	hydroxymethylbilane synthase activity
C7S20_RS06290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C7S20_RS06305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7S20_RS06310	COG0534	Mate efflux family protein
C7S20_RS06320	COG1981	membrane
C7S20_RS06330	COG1024	Enoyl-CoA hydratase
C7S20_RS06340	COG1418	mRNA catabolic process
C7S20_RS06395	COG1999	signal sequence binding
C7S20_RS06400	COG0750	zinc metalloprotease
C7S20_RS06450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7S20_RS06455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7S20_RS06460	COG1335	isochorismatase
C7S20_RS06475	COG1381	Involved in DNA repair and RecF pathway recombination
C7S20_RS06480	COG4206	TonB-dependent receptor
C7S20_RS06485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7S20_RS06505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7S20_RS06515	COG2198	Histidine kinase
C7S20_RS06515	COG2205	protein histidine kinase activity
C7S20_RS06515	COG0784	Response regulator, receiver
C7S20_RS06520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7S20_RS06530	COG0189	ligase activity
C7S20_RS06540	COG0322	excinuclease ABC activity
C7S20_RS06545	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7S20_RS06555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C7S20_RS06565	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C7S20_RS06575	COG3483	tryptophan 2,3-dioxygenase activity
C7S20_RS06585	COG0166	Belongs to the GPI family
C7S20_RS06600	COG2356	endonuclease I
C7S20_RS06630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7S20_RS06650	COG0436	Aminotransferase
C7S20_RS06660	COG1053	succinate dehydrogenase
C7S20_RS06675	COG0484	heat shock protein binding
C7S20_RS06685	COG2610	gluconate transmembrane transporter activity
C7S20_RS06690	COG1929	Belongs to the glycerate kinase type-1 family
C7S20_RS06700	COG0006	proline dipeptidase activity
C7S20_RS06715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C7S20_RS06720	COG0316	Belongs to the HesB IscA family
C7S20_RS06730	COG0719	Fe-S assembly protein
C7S20_RS06740	COG0396	ATPase activity
C7S20_RS06745	COG0719	Fe-S assembly protein
C7S20_RS06750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7S20_RS06765	COG2166	iron-sulfur cluster assembly
C7S20_RS06770	COG2151	metal-sulfur cluster biosynthetic enzyme
C7S20_RS06785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7S20_RS06815	COG2329	Antibiotic biosynthesis monooxygenase
C7S20_RS06830	COG0629	single-stranded DNA binding
C7S20_RS06835	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7S20_RS06840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S20_RS06840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S20_RS06850	COG0792	nuclease activity
C7S20_RS06855	COG1132	(ABC) transporter
C7S20_RS06860	COG0390	transport system, permease component
C7S20_RS06870	COG3590	peptidase
C7S20_RS06890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S20_RS06910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7S20_RS06945	COG0567	Dehydrogenase, E1 component
C7S20_RS06950	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS06960	COG2177	Part of the ABC transporter FtsEX involved in
C7S20_RS06970	COG1968	undecaprenyl-diphosphatase activity
C7S20_RS06975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7S20_RS06985	COG0519	Catalyzes the synthesis of GMP from XMP
C7S20_RS06990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C7S20_RS07005	COG5002	protein histidine kinase activity
C7S20_RS07015	COG0537	adenosine 5'-monophosphoramidase activity
C7S20_RS07020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S20_RS07040	COG2204	response regulator
C7S20_RS07080	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C7S20_RS07090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C7S20_RS07110	COG0495	leucyl-tRNA aminoacylation
C7S20_RS07115	COG0686	Belongs to the AlaDH PNT family
C7S20_RS07120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7S20_RS07125	COG0228	four-way junction DNA binding
C7S20_RS07140	COG3118	belongs to the thioredoxin family
C7S20_RS07175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S20_RS07185	COG1331	Highly conserved protein containing a thioredoxin domain
C7S20_RS07205	COG0745	RESPONSE REGULATOR receiver
C7S20_RS07230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C7S20_RS07235	COG1595	DNA-templated transcription, initiation
C7S20_RS07265	COG0028	Belongs to the TPP enzyme family
C7S20_RS07270	COG2116	formate transmembrane transporter activity
C7S20_RS07285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS07330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S20_RS07350	COG1216	Glycosyl transferase, family 2
C7S20_RS07355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS07360	COG4772	TonB-dependent receptor
C7S20_RS07365	COG0745	RESPONSE REGULATOR receiver
C7S20_RS07380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7S20_RS07380	COG0574	Belongs to the PEP-utilizing enzyme family
C7S20_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS07400	COG5002	protein histidine kinase activity
C7S20_RS07415	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C7S20_RS07425	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS07455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7S20_RS07455	COG0392	lysyltransferase activity
C7S20_RS07465	COG0583	DNA-binding transcription factor activity
C7S20_RS07480	COG3002	Belongs to the UPF0753 family
C7S20_RS07485	COG1331	Highly conserved protein containing a thioredoxin domain
C7S20_RS07490	COG0673	inositol 2-dehydrogenase activity
C7S20_RS07520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7S20_RS07525	COG0363	glucosamine-6-phosphate deaminase activity
C7S20_RS07530	COG1846	Transcriptional regulator
C7S20_RS07530	COG1940	carbohydrate kinase activity
C7S20_RS07540	COG4771	TonB-dependent receptor
C7S20_RS07560	COG0823	Involved in the tonB-independent uptake of proteins
C7S20_RS07575	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS07590	COG0346	lactoylglutathione lyase activity
C7S20_RS07615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7S20_RS07630	COG0288	reversible hydration of carbon dioxide
C7S20_RS07635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7S20_RS07645	COG2207	Transcriptional regulator
C7S20_RS07655	COG2130	NADP-dependent
C7S20_RS07660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7S20_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S20_RS07690	COG2205	protein histidine kinase activity
C7S20_RS07690	COG2198	Histidine kinase
C7S20_RS07690	COG0784	Response regulator, receiver
C7S20_RS07695	COG0745	RESPONSE REGULATOR receiver
C7S20_RS07705	COG1295	ribonuclease BN
C7S20_RS07720	COG2827	Endonuclease containing a URI domain
C7S20_RS07735	COG2205	protein histidine kinase activity
C7S20_RS07750	COG3158	transport of potassium into the cell
C7S20_RS07765	COG2204	response regulator
C7S20_RS07770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7S20_RS07775	COG0569	domain protein
C7S20_RS07790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C7S20_RS07795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C7S20_RS07800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C7S20_RS07810	COG2205	protein histidine kinase activity
C7S20_RS07815	COG5002	protein histidine kinase activity
C7S20_RS07820	COG1477	protein flavinylation
C7S20_RS07850	COG4628	conserved protein (DUF2132)
C7S20_RS07865	COG2315	Protein conserved in bacteria
C7S20_RS07900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S20_RS07910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C7S20_RS07915	COG0463	Glycosyl transferase, family 2
C7S20_RS07950	COG2072	flavoprotein involved in K transport
C7S20_RS07965	COG0084	hydrolase, TatD family'
C7S20_RS07975	COG0252	asparaginase activity
C7S20_RS07985	COG0811	peptide transport
C7S20_RS08015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7S20_RS08020	COG0564	pseudouridine synthase activity
C7S20_RS08025	COG0017	Asparaginyl-tRNA synthetase
C7S20_RS08040	COG0233	cytoplasmic translational termination
C7S20_RS08045	COG0528	UMP kinase activity
C7S20_RS08050	COG2738	Putative neutral zinc metallopeptidase
C7S20_RS08055	COG1522	sequence-specific DNA binding
C7S20_RS08065	COG2363	Small membrane protein
C7S20_RS08070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7S20_RS08085	COG0463	Glycosyl transferase, family 2
C7S20_RS08090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S20_RS08105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7S20_RS08125	COG4771	TonB-dependent receptor
C7S20_RS08135	COG0745	RESPONSE REGULATOR receiver
C7S20_RS08140	COG5002	protein histidine kinase activity
C7S20_RS08145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7S20_RS08150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7S20_RS08165	COG0489	protein tyrosine kinase activity
C7S20_RS08175	COG0492	ferredoxin-NADP+ reductase activity
C7S20_RS08190	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS08195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7S20_RS08200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7S20_RS08205	COG0052	Belongs to the universal ribosomal protein uS2 family
C7S20_RS08210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7S20_RS08215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7S20_RS08225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7S20_RS08225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7S20_RS08235	COG1446	asparaginase
C7S20_RS08250	COG3118	belongs to the thioredoxin family
C7S20_RS08275	COG0427	acetyl-CoA hydrolase
C7S20_RS08310	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C7S20_RS08325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S20_RS08335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C7S20_RS08365	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS08370	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS08385	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS08460	COG0589	response to stress
C7S20_RS08465	COG0779	Required for maturation of 30S ribosomal subunits
C7S20_RS08470	COG0195	Participates in both transcription termination and antitermination
C7S20_RS08475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7S20_RS08490	COG0437	4 iron, 4 sulfur cluster binding
C7S20_RS08520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7S20_RS08525	COG2255	four-way junction helicase activity
C7S20_RS08530	COG2827	Endonuclease containing a URI domain
C7S20_RS08550	COG2207	Transcriptional regulator
C7S20_RS08560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7S20_RS08565	COG0280	phosphate acetyltransferase
C7S20_RS08565	COG0281	malic enzyme
C7S20_RS08570	COG0632	four-way junction helicase activity
C7S20_RS08580	COG0509	glycine decarboxylation via glycine cleavage system
C7S20_RS08605	COG0109	protoheme IX farnesyltransferase activity
C7S20_RS08630	COG1999	signal sequence binding
C7S20_RS08635	COG2322	membrane
C7S20_RS08645	COG1136	(ABC) transporter
C7S20_RS08650	COG0577	efflux transmembrane transporter activity
C7S20_RS08650	COG1136	(ABC) transporter
C7S20_RS08655	COG0577	efflux transmembrane transporter activity
C7S20_RS08655	COG1136	(ABC) transporter
C7S20_RS08660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S20_RS08675	COG1214	PFAM Peptidase M22, glycoprotease
C7S20_RS08680	COG0668	transmembrane transport
C7S20_RS08685	COG1331	Highly conserved protein containing a thioredoxin domain
C7S20_RS08705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7S20_RS08725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7S20_RS08735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7S20_RS08745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C7S20_RS08750	COG0596	Alpha beta hydrolase
C7S20_RS08765	COG1950	PFAM Membrane protein of
C7S20_RS08770	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7S20_RS08780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7S20_RS08785	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C7S20_RS08805	COG0739	heme binding
C7S20_RS08810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7S20_RS08835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C7S20_RS08845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C7S20_RS08850	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7S20_RS08855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7S20_RS08880	COG1428	Deoxynucleoside kinase
C7S20_RS08890	COG0750	zinc metalloprotease
C7S20_RS08940	COG2852	Protein conserved in bacteria
C7S20_RS08960	COG0531	amino acid
C7S20_RS09035	COG4191	Histidine kinase
C7S20_RS09035	COG0784	Response regulator, receiver
C7S20_RS09065	COG4946	Tricorn protease homolog
C7S20_RS09065	COG0793	Belongs to the peptidase S41A family
C7S20_RS09085	COG2827	Endonuclease containing a URI domain
C7S20_RS09090	COG4771	TonB-dependent receptor
C7S20_RS09110	COG2755	lipolytic protein G-D-S-L family
C7S20_RS09110	COG0657	acetylesterase activity
C7S20_RS09115	COG1119	ATPase activity
C7S20_RS09145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7S20_RS09175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7S20_RS09180	COG0732	type I restriction modification DNA specificity domain
C7S20_RS09225	COG3328	transposase activity
C7S20_RS09245	COG3279	Response regulator of the LytR AlgR family
C7S20_RS09250	COG2972	Histidine kinase
C7S20_RS09290	COG1519	Transferase
C7S20_RS09300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7S20_RS09315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7S20_RS09325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7S20_RS09340	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C7S20_RS09345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7S20_RS09360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7S20_RS09365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7S20_RS09375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C7S20_RS09380	COG2086	electron transfer activity
C7S20_RS09385	COG0022	dehydrogenase e1 component
C7S20_RS09385	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS09395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7S20_RS09400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C7S20_RS09415	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C7S20_RS09435	COG1428	Deoxynucleoside kinase
C7S20_RS09450	COG3273	potassium ion transport
C7S20_RS09450	COG0471	metal ion transport
C7S20_RS09465	COG1959	2 iron, 2 sulfur cluster binding
C7S20_RS09470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7S20_RS09475	COG0589	response to stress
C7S20_RS09480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7S20_RS09485	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS09490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7S20_RS09500	COG0460	homoserine dehydrogenase
C7S20_RS09500	COG0527	aspartate kinase activity
C7S20_RS09510	COG1959	2 iron, 2 sulfur cluster binding
C7S20_RS09515	COG0175	sulfate reduction
C7S20_RS09520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7S20_RS09525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7S20_RS09530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7S20_RS09530	COG1648	precorrin-2 dehydrogenase activity
C7S20_RS09535	COG0492	ferredoxin-NADP+ reductase activity
C7S20_RS09550	COG1410	methionine synthase
C7S20_RS09550	COG0646	methionine synthase
C7S20_RS09555	COG1410	methionine synthase
C7S20_RS09555	COG0646	methionine synthase
C7S20_RS09560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7S20_RS09575	COG1131	(ABC) transporter
C7S20_RS09580	COG1605	Chorismate mutase
C7S20_RS09580	COG0077	Prephenate dehydratase
C7S20_RS09585	COG0436	Aminotransferase
C7S20_RS09595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7S20_RS09605	COG1162	GTPase activity
C7S20_RS09610	COG1490	D-aminoacyl-tRNA deacylase activity
C7S20_RS09615	COG1694	Mazg nucleotide pyrophosphohydrolase
C7S20_RS09625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7S20_RS09630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7S20_RS09635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7S20_RS09660	COG4771	TonB-dependent receptor
C7S20_RS09695	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS09700	COG3250	beta-galactosidase activity
C7S20_RS09715	COG1610	YqeY-like protein
C7S20_RS09730	COG1621	beta-fructofuranosidase activity
C7S20_RS09735	COG2814	Major facilitator Superfamily
C7S20_RS09745	COG0492	ferredoxin-NADP+ reductase activity
C7S20_RS09750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7S20_RS09755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7S20_RS09760	COG1185	polyribonucleotide nucleotidyltransferase activity
C7S20_RS09765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7S20_RS09770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7S20_RS09775	COG0191	fructose-bisphosphate aldolase activity
C7S20_RS09795	COG2226	methyltransferase
C7S20_RS09800	COG0436	Aminotransferase
C7S20_RS09805	COG0357	Ribosomal RNA small subunit methyltransferase G
C7S20_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
C7S20_RS09845	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7S20_RS09850	COG1805	sodium ion transport
C7S20_RS09860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7S20_RS09865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7S20_RS09880	COG1477	protein flavinylation
C7S20_RS09905	COG3118	belongs to the thioredoxin family
C7S20_RS09910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C7S20_RS09925	COG2989	Protein conserved in bacteria
C7S20_RS09935	COG0740	serine-type endopeptidase activity
C7S20_RS09960	COG0101	tRNA pseudouridine synthase activity
C7S20_RS09965	COG1132	(ABC) transporter
C7S20_RS09970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C7S20_RS09975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7S20_RS09990	COG0149	triose-phosphate isomerase activity
C7S20_RS09995	COG2264	protein methyltransferase activity
C7S20_RS10050	COG0577	efflux transmembrane transporter activity
C7S20_RS10050	COG1136	(ABC) transporter
C7S20_RS10055	COG1136	(ABC) transporter
C7S20_RS10105	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C7S20_RS10115	COG3250	beta-galactosidase activity
C7S20_RS10120	COG3250	beta-galactosidase activity
C7S20_RS10130	COG0702	epimerase
C7S20_RS10135	COG1629	transport
C7S20_RS10140	COG0745	RESPONSE REGULATOR receiver
C7S20_RS10140	COG2205	protein histidine kinase activity
C7S20_RS10140	COG3292	Two component regulator propeller
C7S20_RS10145	COG4771	TonB-dependent receptor
C7S20_RS10150	COG0702	epimerase
C7S20_RS10165	COG0657	acetylesterase activity
C7S20_RS10165	COG2755	lipolytic protein G-D-S-L family
C7S20_RS10170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C7S20_RS10185	COG4771	TonB-dependent receptor
C7S20_RS10190	COG0561	phosphatase activity
C7S20_RS10205	COG4771	TonB-dependent receptor
C7S20_RS10210	COG0702	epimerase
C7S20_RS10225	COG4771	TonB-dependent receptor
C7S20_RS10235	COG4771	TonB-dependent receptor
C7S20_RS10240	COG0702	epimerase
C7S20_RS10270	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C7S20_RS10280	COG3254	rhamnose metabolic process
C7S20_RS10300	COG3250	beta-galactosidase activity
C7S20_RS10310	COG3250	beta-galactosidase activity
C7S20_RS10320	COG2755	lipolytic protein G-D-S-L family
C7S20_RS10330	COG2755	lipolytic protein G-D-S-L family
C7S20_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS10345	COG3347	Dehydrogenase
C7S20_RS10350	COG4952	isomerase
C7S20_RS10360	COG0247	lactate metabolic process
C7S20_RS10365	COG1139	Iron-sulfur cluster binding protein
C7S20_RS10370	COG1556	Lactate utilization protein
C7S20_RS10385	COG3401	FG-GAP repeat protein
C7S20_RS10390	COG3401	FG-GAP repeat protein
C7S20_RS10395	COG1584	GPR1 FUN34 yaaH family protein
C7S20_RS10420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C7S20_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS10430	COG1904	glucuronate isomerase
C7S20_RS10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7S20_RS10440	COG0800	Aldolase
C7S20_RS10450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C7S20_RS10455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C7S20_RS10465	COG0246	Mannitol dehydrogenase
C7S20_RS10470	COG2721	sulfolactate sulfo-lyase activity
C7S20_RS10485	COG4771	TonB-dependent receptor
C7S20_RS10490	COG0702	epimerase
C7S20_RS10520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C7S20_RS10535	COG2755	lipolytic protein G-D-S-L family
C7S20_RS10545	COG2755	lipolytic protein G-D-S-L family
C7S20_RS10555	COG1312	Catalyzes the dehydration of D-mannonate
C7S20_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS10570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C7S20_RS10575	COG3119	arylsulfatase activity
C7S20_RS10615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7S20_RS10625	COG1629	transport
C7S20_RS10625	COG4206	TonB-dependent receptor
C7S20_RS10645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7S20_RS10660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7S20_RS10665	COG0284	orotidine-5'-phosphate decarboxylase activity
C7S20_RS10670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7S20_RS10685	COG0788	formyltetrahydrofolate deformylase activity
C7S20_RS10690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS10690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS10690	COG1703	isobutyryl-CoA mutase activity
C7S20_RS10710	COG1522	sequence-specific DNA binding
C7S20_RS10740	COG0004	ammonium transporteR
C7S20_RS10750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7S20_RS10775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S20_RS10790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7S20_RS10795	COG0484	heat shock protein binding
C7S20_RS10800	COG4152	abc transporter atp-binding protein
C7S20_RS10810	COG3264	Mechanosensitive ion channel
C7S20_RS10810	COG1196	nuclear chromosome segregation
C7S20_RS10835	COG2326	polyphosphate kinase activity
C7S20_RS10845	COG0534	Mate efflux family protein
C7S20_RS10855	COG0671	phosphoesterase, PA-phosphatase related
C7S20_RS10865	COG1764	response to oxidative stress
C7S20_RS10925	COG0653	protein targeting
C7S20_RS10965	COG3876	Protein conserved in bacteria
C7S20_RS10970	COG0577	efflux transmembrane transporter activity
C7S20_RS10995	COG1115	amino acid carrier protein
C7S20_RS11005	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS11010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S20_RS11015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7S20_RS11020	COG4974	Belongs to the 'phage' integrase family
C7S20_RS11025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7S20_RS11050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7S20_RS11070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7S20_RS11075	COG0081	regulation of translation
C7S20_RS11080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7S20_RS11085	COG0222	ribosome binding
C7S20_RS11090	COG0085	RNA polymerase activity
C7S20_RS11095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7S20_RS11100	COG2318	DinB family
C7S20_RS11110	COG4948	Mandelate Racemase Muconate Lactonizing
C7S20_RS11115	COG0156	8-amino-7-oxononanoate synthase activity
C7S20_RS11120	COG1115	amino acid carrier protein
C7S20_RS11125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7S20_RS11135	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C7S20_RS11145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7S20_RS11160	COG0579	oxidoreductase
C7S20_RS11175	COG0561	phosphatase activity
C7S20_RS11215	COG5002	protein histidine kinase activity
C7S20_RS11215	COG2198	Histidine kinase
C7S20_RS11215	COG0784	Response regulator, receiver
C7S20_RS11225	COG0326	Molecular chaperone. Has ATPase activity
C7S20_RS11245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S20_RS11265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS11290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7S20_RS11315	COG1473	amidohydrolase
C7S20_RS11330	COG0009	L-threonylcarbamoyladenylate synthase
C7S20_RS11335	COG1360	Flagellar Motor Protein
C7S20_RS11355	COG1575	Belongs to the MenA family. Type 1 subfamily
C7S20_RS11360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7S20_RS11365	COG4948	Mandelate Racemase Muconate Lactonizing
C7S20_RS11370	COG1266	CAAX protease self-immunity
C7S20_RS11385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7S20_RS11400	COG0488	(ABC) transporter
C7S20_RS11425	COG0556	nucleotide-excision repair
C7S20_RS11455	COG1612	heme a metabolic process
C7S20_RS11460	COG3620	sequence-specific DNA binding
C7S20_RS11460	COG0617	tRNA 3'-terminal CCA addition
C7S20_RS11460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7S20_RS11490	COG0859	PFAM glycosyl transferase family 9
C7S20_RS11495	COG2171	N-acyltransferase activity
C7S20_RS11500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7S20_RS11510	COG0242	peptide deformylase activity
C7S20_RS11525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7S20_RS11550	COG3237	CsbD-like
C7S20_RS11555	COG0542	response to heat
C7S20_RS11575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7S20_RS11595	COG0300	oxidoreductase activity
C7S20_RS11600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7S20_RS11610	COG0488	(ABC) transporter
C7S20_RS11630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S20_RS11635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7S20_RS11640	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S20_RS11665	COG1058	Belongs to the CinA family
C7S20_RS11665	COG1546	Belongs to the CinA family
C7S20_RS11670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7S20_RS11675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7S20_RS11685	COG0552	protein localization to endoplasmic reticulum
C7S20_RS11710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7S20_RS11715	COG1830	Aldolase
C7S20_RS11740	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C7S20_RS11745	COG0076	glutamate decarboxylase activity
C7S20_RS11760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7S20_RS11760	COG0519	Catalyzes the synthesis of GMP from XMP
C7S20_RS11765	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7S20_RS11765	COG1388	LysM domain
C7S20_RS11790	COG0482	sulfurtransferase activity
C7S20_RS11805	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7S20_RS11810	COG0706	membrane insertase activity
C7S20_RS11815	COG0504	CTP synthase activity
C7S20_RS11850	COG2031	fatty acid transporter
C7S20_RS11865	COG3279	Response regulator of the LytR AlgR family
C7S20_RS11870	COG3275	phosphorelay sensor kinase activity
C7S20_RS11875	COG1272	protein, Hemolysin III
C7S20_RS11900	COG0019	diaminopimelate decarboxylase activity
C7S20_RS11905	COG2814	Major facilitator Superfamily
C7S20_RS11910	COG0045	succinate-CoA ligase (ADP-forming) activity
C7S20_RS11940	COG0010	Belongs to the arginase family
C7S20_RS11945	COG1228	amidohydrolase
C7S20_RS11950	COG1064	alcohol dehydrogenase
C7S20_RS11955	COG0626	cystathionine gamma-synthase activity
C7S20_RS11960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7S20_RS11970	COG3956	TIGRFAM MazG family protein
C7S20_RS11985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7S20_RS12005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7S20_RS12025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7S20_RS12035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7S20_RS12040	COG0501	Belongs to the peptidase M48B family
C7S20_RS12045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7S20_RS12050	COG1228	amidohydrolase
C7S20_RS12055	COG1228	amidohydrolase
C7S20_RS12065	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7S20_RS12070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S20_RS12080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7S20_RS12085	COG0105	UTP biosynthetic process
C7S20_RS12095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S20_RS12110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7S20_RS12120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7S20_RS12130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7S20_RS12160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7S20_RS12170	COG1475	DNA binding
C7S20_RS12175	COG1192	Involved in chromosome partitioning
C7S20_RS12180	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS12190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS12190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS12195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS12195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S20_RS12205	COG0572	uridine kinase
C7S20_RS12210	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS12220	COG1216	Glycosyl transferase, family 2
C7S20_RS12220	COG0463	Glycosyl transferase, family 2
C7S20_RS12230	COG1696	Membrane protein involved in D-alanine export
C7S20_RS12240	COG2010	Cytochrome c
C7S20_RS12265	COG0463	Glycosyl transferase, family 2
C7S20_RS12275	COG3590	peptidase
C7S20_RS12280	COG0656	L-ascorbic acid biosynthetic process
C7S20_RS12285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C7S20_RS12290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C7S20_RS12300	COG4974	Belongs to the 'phage' integrase family
C7S20_RS12320	COG2885	chlorophyll binding
C7S20_RS12335	COG0205	6-phosphofructokinase activity
C7S20_RS12360	COG0004	ammonium transporteR
C7S20_RS12365	COG1794	racemase activity, acting on amino acids and derivatives
C7S20_RS12380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C7S20_RS12400	COG3250	beta-galactosidase activity
C7S20_RS12430	COG0670	Belongs to the BI1 family
C7S20_RS12435	COG4106	trans-aconitate 2-methyltransferase activity
C7S20_RS12445	COG0110	maltose O-acetyltransferase activity
C7S20_RS12455	COG0076	glutamate decarboxylase activity
C7S20_RS12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S20_RS12495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S20_RS12530	COG3609	addiction module antidote protein, CC2985 family
C7S20_RS12610	COG3328	transposase activity
C7S20_RS12665	COG1484	DNA-dependent DNA replication
C7S20_RS12670	COG4584	PFAM Integrase catalytic
C7S20_RS12750	COG3668	Plasmid stabilization system
C7S20_RS12755	COG3609	addiction module antidote protein, CC2985 family
C7S20_RS12780	COG4974	Belongs to the 'phage' integrase family
C7S20_RS12795	COG0730	response to heat
C7S20_RS12800	COG1271	oxidase subunit
C7S20_RS12860	COG0439	Biotin carboxylase
C7S20_RS12865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7S20_RS12880	COG4680	protein conserved in bacteria
C7S20_RS12890	COG0587	DNA-directed DNA polymerase activity
C7S20_RS12890	COG0587	DNA-directed DNA polymerase activity
C7S20_RS12905	COG2860	membrane
C7S20_RS12910	COG0492	ferredoxin-NADP+ reductase activity
C7S20_RS12970	COG0714	Associated with various cellular activities
C7S20_RS13000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S20_RS13005	COG0494	nUDIX hydrolase
C7S20_RS13035	COG3275	phosphorelay sensor kinase activity
C7S20_RS13045	COG3279	Response regulator of the LytR AlgR family
C7S20_RS13055	COG1595	DNA-templated transcription, initiation
C7S20_RS13080	COG0673	inositol 2-dehydrogenase activity
C7S20_RS13085	COG2211	Major facilitator Superfamily
C7S20_RS13105	COG2197	response regulator
C7S20_RS13115	COG2201	protein-glutamate methylesterase activity
C7S20_RS13140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7S20_RS13145	COG0540	Belongs to the ATCase OTCase family
C7S20_RS13155	COG1234	tRNA 3'-trailer cleavage
C7S20_RS13185	COG0259	pyridoxamine-phosphate oxidase activity
C7S20_RS13195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7S20_RS13210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7S20_RS13230	COG0742	ribosomal rna small subunit methyltransferase
C7S20_RS13245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7S20_RS13250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C7S20_RS13255	COG0415	Belongs to the DNA photolyase family
C7S20_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS13280	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S20_RS13300	COG0424	maF-like protein
C7S20_RS13320	COG1333	cytochrome c biogenesis protein
C7S20_RS13320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7S20_RS13345	COG1393	Belongs to the ArsC family
C7S20_RS13350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C7S20_RS13365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7S20_RS13380	COG0156	8-amino-7-oxononanoate synthase activity
C7S20_RS13415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7S20_RS13425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7S20_RS13430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7S20_RS13450	COG0802	atpase or kinase
C7S20_RS13455	COG2204	response regulator
C7S20_RS13460	COG1078	dGTPase activity
C7S20_RS13465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S20_RS13470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C7S20_RS13470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7S20_RS13475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S20_RS13480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7S20_RS13505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7S20_RS13525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7S20_RS13530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7S20_RS13535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7S20_RS13540	COG0131	Imidazoleglycerol-phosphate dehydratase
C7S20_RS13545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7S20_RS13555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7S20_RS13560	COG0107	imidazoleglycerol-phosphate synthase activity
C7S20_RS13565	COG0140	phosphoribosyl-ATP diphosphatase activity
C7S20_RS13565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7S20_RS13570	COG1741	Belongs to the pirin family
C7S20_RS13585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C7S20_RS13600	COG1506	peptidase
C7S20_RS13600	COG0823	Involved in the tonB-independent uptake of proteins
C7S20_RS13615	COG0101	tRNA pseudouridine synthase activity
C7S20_RS13620	COG0598	Magnesium transport protein CorA
C7S20_RS13625	COG2706	6-phosphogluconolactonase activity
C7S20_RS13640	COG0189	ligase activity
C7S20_RS13655	COG1629	transport
C7S20_RS13660	COG0702	epimerase
C7S20_RS13665	COG3534	alpha-L-arabinofuranosidase
C7S20_RS13670	COG3507	Belongs to the glycosyl hydrolase 43 family
C7S20_RS13680	COG3507	Belongs to the glycosyl hydrolase 43 family
C7S20_RS13685	COG3507	Belongs to the glycosyl hydrolase 43 family
C7S20_RS13695	COG1069	ribulokinase activity
C7S20_RS13705	COG2160	L-arabinose isomerase activity
C7S20_RS13720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7S20_RS13725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7S20_RS13735	COG1082	Xylose isomerase domain protein TIM barrel
C7S20_RS13740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S20_RS13740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7S20_RS13745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S20_RS13750	COG1127	ABC transporter
C7S20_RS13795	COG1482	cell wall glycoprotein biosynthetic process
C7S20_RS13800	COG0667	Aldo Keto reductase
C7S20_RS13815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7S20_RS13840	COG5002	protein histidine kinase activity
C7S20_RS13855	COG1476	TRANSCRIPTIONal
C7S20_RS13890	COG0012	GTP binding
C7S20_RS13910	COG1970	mechanosensitive ion channel activity
C7S20_RS13930	COG1522	sequence-specific DNA binding
C7S20_RS13935	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C7S20_RS13950	COG0693	protein deglycase activity
C7S20_RS13960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7S20_RS13975	COG0217	transcriptional regulatory protein
C7S20_RS13980	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7S20_RS13990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7S20_RS13995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7S20_RS13995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7S20_RS14000	COG2986	histidine ammonia-lyase
C7S20_RS14010	COG0542	response to heat
C7S20_RS14015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7S20_RS14030	COG0183	Belongs to the thiolase family
C7S20_RS14035	COG1480	7TM receptor with intracellular HD hydrolase
C7S20_RS14060	COG1012	belongs to the aldehyde dehydrogenase family
C7S20_RS14075	COG1607	acyl-coa hydrolase
C7S20_RS14080	COG3264	Mechanosensitive ion channel
C7S20_RS14080	COG1196	nuclear chromosome segregation
C7S20_RS14090	COG0668	transmembrane transport
C7S20_RS14095	COG2814	Major facilitator Superfamily
C7S20_RS14100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7S20_RS14130	COG1289	transmembrane transporter activity
C7S20_RS14155	COG1045	serine acetyltransferase
C7S20_RS14170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S20_RS14180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7S20_RS14195	COG0189	ligase activity
C7S20_RS14210	COG1764	response to oxidative stress
C7S20_RS14215	COG1047	Peptidyl-prolyl cis-trans
C7S20_RS14220	COG0673	inositol 2-dehydrogenase activity
C7S20_RS14240	COG0527	aspartate kinase activity
C7S20_RS14250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S20_RS14260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7S20_RS14265	COG2610	gluconate transmembrane transporter activity
C7S20_RS14285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7S20_RS14310	COG0604	alcohol dehydrogenase
C7S20_RS14315	COG2084	Dehydrogenase
C7S20_RS14335	COG0628	permease
C7S20_RS14350	COG2211	Major facilitator Superfamily
C7S20_RS14355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S20_RS14370	COG2514	catechol 2,3-dioxygenase activity
C7S20_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS14400	COG2135	peptidase activity
C7S20_RS14405	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS14420	COG0590	tRNA wobble adenosine to inosine editing
C7S20_RS14430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7S20_RS14450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S20_RS14465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7S20_RS14470	COG3424	synthase
C7S20_RS14480	COG0644	oxidoreductase
C7S20_RS14485	COG2885	chlorophyll binding
C7S20_RS14500	COG0022	dehydrogenase e1 component
C7S20_RS14510	COG0023	Translation Initiation Factor
C7S20_RS14520	COG0813	purine-nucleoside phosphorylase activity
C7S20_RS14525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7S20_RS14545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7S20_RS14550	COG1193	negative regulation of DNA recombination
C7S20_RS14555	COG3011	Protein conserved in bacteria
C7S20_RS14560	COG1301	dicarboxylic acid transport
C7S20_RS14565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7S20_RS14575	COG0745	RESPONSE REGULATOR receiver
C7S20_RS14585	COG0247	lactate metabolic process
C7S20_RS14585	COG0277	FAD linked oxidase domain protein
C7S20_RS14595	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS14600	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S20_RS14610	COG2181	nitrate reductase activity
C7S20_RS14610	COG0247	lactate metabolic process
C7S20_RS14615	COG0247	lactate metabolic process
C7S20_RS14615	COG2181	nitrate reductase activity
C7S20_RS14625	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7S20_RS14635	COG0251	oxidation-reduction process
C7S20_RS14645	COG0205	6-phosphofructokinase activity
C7S20_RS14655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7S20_RS14670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7S20_RS14675	COG0628	permease
C7S20_RS14685	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C7S20_RS14700	COG1216	Glycosyl transferase, family 2
C7S20_RS14705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7S20_RS14715	COG0726	polysaccharide deacetylase
C7S20_RS14725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S20_RS14730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S20_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS14765	COG2986	histidine ammonia-lyase
C7S20_RS14800	COG3256	nitric oxide reductase
C7S20_RS14805	COG3850	Histidine kinase
C7S20_RS14805	COG3437	response regulator, receiver
C7S20_RS14805	COG2205	protein histidine kinase activity
C7S20_RS14805	COG4999	Histidine kinase
C7S20_RS14810	COG3279	Response regulator of the LytR AlgR family
C7S20_RS14840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7S20_RS14850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7S20_RS14855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7S20_RS14890	COG0302	gtp cyclohydrolase
C7S20_RS14895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S20_RS14905	COG1136	(ABC) transporter
C7S20_RS14920	COG4251	negative regulation of phosphorylation
C7S20_RS14930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S20_RS14950	COG1234	tRNA 3'-trailer cleavage
C7S20_RS14960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7S20_RS14980	COG0514	ATP-dependent DNA helicase (RecQ)
C7S20_RS14985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7S20_RS14995	COG1678	Uncharacterized ACR, COG1678
C7S20_RS15080	COG0861	Integral membrane protein TerC family
C7S20_RS15090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7S20_RS15095	COG4974	Belongs to the 'phage' integrase family
C7S20_RS15100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7S20_RS15110	COG5290	Psort location Cytoplasmic, score
C7S20_RS15115	COG0732	type I restriction modification DNA specificity domain
C7S20_RS15120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C7S20_RS15130	COG4771	TonB-dependent receptor
C7S20_RS15135	COG0702	epimerase
C7S20_RS15160	COG0156	8-amino-7-oxononanoate synthase activity
C7S20_RS15180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S20_RS15185	COG0464	growth
C7S20_RS15265	COG2003	Belongs to the UPF0758 family
C7S20_RS15270	COG0629	single-stranded DNA binding
C7S20_RS15325	COG0701	Predicted permease
C7S20_RS15330	COG2814	Major facilitator Superfamily
C7S20_RS15415	COG2132	Multicopper oxidase
C7S20_RS15430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS15435	COG3260	NADH ubiquinone oxidoreductase 20
C7S20_RS15440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7S20_RS15450	COG0713	ATP synthesis coupled electron transport
C7S20_RS15460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S20_RS15465	COG1007	ATP synthesis coupled electron transport
C7S20_RS15490	COG2132	Multicopper oxidase
C7S20_RS15515	COG2217	Heavy metal translocating P-type atpase
C7S20_RS15545	COG0347	Belongs to the P(II) protein family
C7S20_RS15570	COG2132	Multicopper oxidase
C7S20_RS15625	COG2217	Heavy metal translocating P-type atpase
C7S20_RS15640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7S20_RS15645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7S20_RS15650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C7S20_RS15800	COG4584	PFAM Integrase catalytic
C7S20_RS15805	COG1484	DNA-dependent DNA replication
C7S20_RS15865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7S20_RS15890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7S20_RS15895	COG2010	Cytochrome c
C7S20_RS15895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7S20_RS15910	COG0028	Belongs to the TPP enzyme family
C7S20_RS15920	COG0277	FAD linked oxidase domain protein
C7S20_RS15920	COG0247	lactate metabolic process
C7S20_RS15945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S20_RS15950	COG0667	Aldo Keto reductase
C7S20_RS15955	COG0124	histidyl-tRNA synthetase
C7S20_RS15970	COG0359	binds to the 23S rRNA
C7S20_RS15975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7S20_RS15980	COG0360	Binds together with S18 to 16S ribosomal RNA
C7S20_RS15985	COG3279	Response regulator of the LytR AlgR family
C7S20_RS15990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7S20_RS16015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7S20_RS16020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7S20_RS16045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7S20_RS16085	COG4206	TonB-dependent receptor
C7S20_RS16095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7S20_RS16100	COG1120	ATPase activity
C7S20_RS16120	COG1607	acyl-coa hydrolase
C7S20_RS16130	COG2363	Small membrane protein
C7S20_RS16135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7S20_RS16140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7S20_RS16150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S20_RS16165	COG1741	Belongs to the pirin family
C7S20_RS16175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7S20_RS16190	COG0254	rRNA binding
C7S20_RS16200	COG0463	Glycosyl transferase, family 2
C7S20_RS16205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7S20_RS16210	COG1132	(ABC) transporter
C7S20_RS16215	COG1595	DNA-templated transcription, initiation
C7S20_RS16235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S20_RS16235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7S20_RS16245	COG0047	phosphoribosylformylglycinamidine synthase activity
C7S20_RS16245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7S20_RS16255	COG1022	Amp-dependent synthetase and ligase
C7S20_RS16260	COG1846	Transcriptional regulator
C7S20_RS16265	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S20_RS16265	COG1024	Enoyl-CoA hydratase
C7S20_RS16275	COG0183	Belongs to the thiolase family
C7S20_RS16285	COG1960	acyl-CoA dehydrogenase activity
C7S20_RS16300	COG3387	PFAM Glycoside hydrolase 15-related
C7S20_RS16305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C7S20_RS16375	COG4206	TonB-dependent receptor
C7S20_RS16375	COG1629	transport
C7S20_RS16385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7S20_RS16390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7S20_RS16395	COG1595	DNA-templated transcription, initiation
C7S20_RS16415	COG2270	Major facilitator Superfamily
C7S20_RS16435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S20_RS16445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS16470	COG4974	Belongs to the 'phage' integrase family
C7S20_RS16475	COG0656	L-ascorbic acid biosynthetic process
C7S20_RS16480	COG1418	mRNA catabolic process
C7S20_RS16505	COG1104	cysteine desulfurase activity
C7S20_RS16540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7S20_RS16545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7S20_RS16560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7S20_RS16560	COG0116	Belongs to the methyltransferase superfamily
C7S20_RS16575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S20_RS16580	COG1477	protein flavinylation
C7S20_RS16630	COG1363	Peptidase, m42
C7S20_RS16640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7S20_RS16640	COG0517	IMP dehydrogenase activity
C7S20_RS16650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7S20_RS16655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7S20_RS16660	COG1702	phosphate starvation-inducible protein PhoH
C7S20_RS16685	COG0592	DNA-directed DNA polymerase activity
C7S20_RS16705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7S20_RS16715	COG4974	Belongs to the 'phage' integrase family
C7S20_RS16750	COG1194	a g-specific adenine glycosylase
C7S20_RS16900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C7S20_RS16905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S20_RS16930	COG1012	belongs to the aldehyde dehydrogenase family
C7S20_RS16940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7S20_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
C7S20_RS17005	COG1959	2 iron, 2 sulfur cluster binding
C7S20_RS17010	COG2353	YceI-like domain
C7S20_RS17025	COG2353	YceI-like domain
C7S20_RS17035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7S20_RS17045	COG0730	response to heat
C7S20_RS17050	COG0303	'Molybdopterin
C7S20_RS17060	COG0315	cyclic pyranopterin monophosphate synthase activity
C7S20_RS17060	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7S20_RS17070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7S20_RS17080	COG0746	molybdenum cofactor guanylyltransferase activity
C7S20_RS17085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7S20_RS17090	COG1104	cysteine desulfurase activity
C7S20_RS17110	COG0656	L-ascorbic acid biosynthetic process
C7S20_RS17125	COG0667	Aldo Keto reductase
C7S20_RS17150	COG3239	Fatty acid desaturase
C7S20_RS17170	COG1231	oxidoreductase activity
C7S20_RS17185	COG4181	ATPase activity
C7S20_RS17240	COG1187	pseudouridine synthase activity
C7S20_RS17255	COG4251	negative regulation of phosphorylation
C7S20_RS17265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7S20_RS17270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7S20_RS17275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7S20_RS17285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7S20_RS17285	COG0475	glutathione-regulated potassium exporter activity
C7S20_RS17290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C7S20_RS17295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7S20_RS17300	COG0083	homoserine kinase activity
C7S20_RS17305	COG0460	homoserine dehydrogenase
C7S20_RS17305	COG0527	aspartate kinase activity
C7S20_RS17330	COG0643	Histidine kinase
C7S20_RS17330	COG0784	Response regulator, receiver
C7S20_RS17330	COG2198	Histidine kinase
C7S20_RS17355	COG1596	polysaccharide export
C7S20_RS17365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7S20_RS17375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7S20_RS17385	COG0438	transferase activity, transferring glycosyl groups
C7S20_RS17395	COG0546	phosphoglycolate phosphatase activity
C7S20_RS17405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7S20_RS17415	COG1132	(ABC) transporter
C7S20_RS17420	COG0367	asparagine synthase
C7S20_RS17445	COG0297	glycogen (starch) synthase activity
C7S20_RS17465	COG1216	Glycosyl transferase, family 2
C7S20_RS17465	COG0463	Glycosyl transferase, family 2
C7S20_RS17470	COG2244	polysaccharide biosynthetic process
C7S20_RS17510	COG0175	sulfate reduction
C7S20_RS17515	COG0529	Catalyzes the synthesis of activated sulfate
C7S20_RS17525	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7S20_RS17535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C7S20_RS17545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C7S20_RS17555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S20_RS17585	COG0783	Belongs to the Dps family
C7S20_RS17590	COG0668	transmembrane transport
C7S20_RS17610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S20_RS17625	COG1560	Kdo2-lipid A biosynthetic process
C7S20_RS17630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7S20_RS17665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7S20_RS17670	COG1611	Belongs to the LOG family
C7S20_RS17680	COG0022	dehydrogenase e1 component
C7S20_RS17700	COG4206	TonB-dependent receptor
C7S20_RS17700	COG1629	transport
C7S20_RS17720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C7S20_RS17725	COG1169	isochorismate synthase
C7S20_RS17745	COG0443	Heat shock 70 kDa protein
C7S20_RS17750	COG1760	l-serine dehydratase
C7S20_RS17765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7S20_RS17775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7S20_RS17780	COG0564	pseudouridine synthase activity
C7S20_RS17795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7S20_RS17800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7S20_RS17805	COG0066	3-isopropylmalate dehydratase activity
C7S20_RS17815	COG0165	Argininosuccinate lyase
C7S20_RS17825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7S20_RS17830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7S20_RS17840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7S20_RS17845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7S20_RS17850	COG0137	argininosuccinate synthase activity
C7S20_RS17860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7S20_RS17865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7S20_RS17875	COG0028	Belongs to the TPP enzyme family
C7S20_RS17880	COG0129	dihydroxy-acid dehydratase activity
C7S20_RS17885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S20_RS17885	COG3153	acetyltransferase
C7S20_RS17890	COG2197	response regulator
C7S20_RS17895	COG4585	Histidine kinase
C7S20_RS17910	COG1984	allophanate hydrolase subunit 2
C7S20_RS17915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7S20_RS17925	COG1914	H( )-stimulated, divalent metal cation uptake system
C7S20_RS17935	COG0606	chelatase, subunit chli
C7S20_RS17950	COG0205	6-phosphofructokinase activity
C7S20_RS17955	COG0366	Alpha amylase catalytic
C7S20_RS17960	COG0366	Alpha amylase catalytic
C7S20_RS17970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7S20_RS17985	COG1629	transport
C7S20_RS17985	COG4206	TonB-dependent receptor
C7S20_RS17990	COG0702	epimerase
C7S20_RS18000	COG0366	Alpha amylase catalytic
C7S20_RS18020	COG3250	beta-galactosidase activity
C7S20_RS18025	COG0702	epimerase
C7S20_RS18030	COG4771	TonB-dependent receptor
C7S20_RS18035	COG0457	Tetratricopeptide repeat
C7S20_RS18040	COG3250	beta-galactosidase activity
C7S20_RS18045	COG0477	Major facilitator Superfamily
C7S20_RS18045	COG2814	Major facilitator Superfamily
C7S20_RS18070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7S20_RS18075	COG1085	galactose-1-phosphate uridylyltransferase
C7S20_RS18080	COG1609	Transcriptional regulator
C7S20_RS18100	COG0037	tRNA processing
C7S20_RS18105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7S20_RS18115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS18120	COG1522	sequence-specific DNA binding
C7S20_RS18125	COG0626	cystathionine gamma-synthase activity
C7S20_RS18130	COG1757	Na H antiporter
C7S20_RS18135	COG0450	alkyl hydroperoxide reductase
C7S20_RS18140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S20_RS18150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C7S20_RS18165	COG1674	ftsk spoiiie
C7S20_RS18180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7S20_RS18180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7S20_RS18185	COG0778	Nitroreductase
C7S20_RS18190	COG2949	membrane
C7S20_RS18240	COG0339	signal peptide processing
C7S20_RS18245	COG1012	belongs to the aldehyde dehydrogenase family
C7S20_RS18250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7S20_RS18270	COG3685	Protein conserved in bacteria
C7S20_RS18290	COG3258	Cytochrome c
C7S20_RS18335	COG3328	transposase activity
C7S20_RS18360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C7S20_RS18405	COG0484	heat shock protein binding
C7S20_RS18410	COG0484	heat shock protein binding
C7S20_RS18420	COG1525	nuclease
C7S20_RS18425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S20_RS18485	COG4585	Histidine kinase
C7S20_RS18500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7S20_RS18530	COG3239	Fatty acid desaturase
C7S20_RS18545	COG2197	response regulator
C7S20_RS18580	COG0640	Transcriptional regulator
C7S20_RS18585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S20_RS18660	COG3852	Histidine kinase
C7S20_RS18665	COG2204	response regulator
C7S20_RS18680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7S20_RS18685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S20_RS18700	COG3250	beta-galactosidase activity
C7S20_RS18715	COG4771	TonB-dependent receptor
C7S20_RS18725	COG2222	sugar isomerase
C7S20_RS18750	COG0673	inositol 2-dehydrogenase activity
C7S20_RS18755	COG1349	DNA-binding transcription factor activity
C7S20_RS18765	COG0366	Alpha amylase catalytic
C7S20_RS18780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S20_RS18790	COG1346	cytolysis
C7S20_RS18800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7S20_RS18820	COG3345	alpha-galactosidase
C7S20_RS18825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7S20_RS18835	COG2186	Transcriptional regulator
C7S20_RS18845	COG0702	epimerase
C7S20_RS18850	COG4771	TonB-dependent receptor
C7S20_RS18865	COG0363	glucosamine-6-phosphate deaminase activity
C7S20_RS18870	COG3250	beta-galactosidase activity
C7S20_RS18885	COG1115	amino acid carrier protein
C7S20_RS18885	COG1115	amino acid carrier protein
C7S20_RS18900	COG4221	oxidoreductase activity
C7S20_RS18915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C7S20_RS18940	COG2010	Cytochrome c
C7S20_RS18950	COG1959	2 iron, 2 sulfur cluster binding
C7S20_RS18985	COG1999	signal sequence binding
C7S20_RS19005	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C7S20_RS19010	COG3256	nitric oxide reductase
C7S20_RS19020	COG3384	dioxygenase
C7S20_RS19025	COG2353	YceI-like domain
C7S20_RS19030	COG2910	NAD(P)H-binding
C7S20_RS19045	COG2353	YceI-like domain
C7S20_RS19055	COG0038	chloride channel
C7S20_RS19060	COG3189	MarR family transcriptional regulator
C7S20_RS19065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7S20_RS19070	COG0629	single-stranded DNA binding
C7S20_RS19075	COG2003	Belongs to the UPF0758 family
C7S20_RS19160	COG0156	8-amino-7-oxononanoate synthase activity
C7S20_RS19185	COG0612	Peptidase, M16
C7S20_RS19190	COG0702	epimerase
C7S20_RS19195	COG1629	transport
C7S20_RS19275	COG2197	response regulator
C7S20_RS19350	COG0085	RNA polymerase activity