locus-tag	class	description
GBCGDNIH2_RS00005	COG0477	Major facilitator Superfamily
GBCGDNIH2_RS00010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GBCGDNIH2_RS00015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GBCGDNIH2_RS00020	COG0424	maF-like protein
GBCGDNIH2_RS00025	COG0495	leucyl-tRNA aminoacylation
GBCGDNIH2_RS00050	COG0357	Ribosomal RNA small subunit methyltransferase G
GBCGDNIH2_RS00055	COG0445	tRNA wobble uridine modification
GBCGDNIH2_RS00060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GBCGDNIH2_RS00070	COG1331	Highly conserved protein containing a thioredoxin domain
GBCGDNIH2_RS00075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GBCGDNIH2_RS00085	COG1278	Cold shock
GBCGDNIH2_RS00095	COG1914	H( )-stimulated, divalent metal cation uptake system
GBCGDNIH2_RS00100	COG1126	abc transporter atp-binding protein
GBCGDNIH2_RS00105	COG0484	heat shock protein binding
GBCGDNIH2_RS00110	COG0443	Heat shock 70 kDa protein
GBCGDNIH2_RS00115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GBCGDNIH2_RS00120	COG1420	regulation of RNA biosynthetic process
GBCGDNIH2_RS00125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GBCGDNIH2_RS00130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GBCGDNIH2_RS00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GBCGDNIH2_RS00155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBCGDNIH2_RS00165	COG1301	dicarboxylic acid transport
GBCGDNIH2_RS00180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBCGDNIH2_RS00200	COG0848	biopolymer transport protein
GBCGDNIH2_RS00235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GBCGDNIH2_RS00240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GBCGDNIH2_RS00245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GBCGDNIH2_RS00250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GBCGDNIH2_RS00255	COG3404	Formiminotransferase-cyclodeaminase
GBCGDNIH2_RS00260	COG0045	succinate-CoA ligase (ADP-forming) activity
GBCGDNIH2_RS00265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GBCGDNIH2_RS00270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GBCGDNIH2_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
GBCGDNIH2_RS00290	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS00295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GBCGDNIH2_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GBCGDNIH2_RS00320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GBCGDNIH2_RS00340	COG1764	response to oxidative stress
GBCGDNIH2_RS00345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GBCGDNIH2_RS00345	COG0519	Catalyzes the synthesis of GMP from XMP
GBCGDNIH2_RS00365	COG0247	lactate metabolic process
GBCGDNIH2_RS00365	COG2181	nitrate reductase activity
GBCGDNIH2_RS00370	COG1902	pentaerythritol trinitrate reductase activity
GBCGDNIH2_RS00370	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBCGDNIH2_RS00385	COG4638	Rieske (2fe-2S)
GBCGDNIH2_RS00395	COG1760	l-serine dehydratase
GBCGDNIH2_RS00405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBCGDNIH2_RS00405	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBCGDNIH2_RS00430	COG4176	ABC-type proline glycine betaine transport system permease component
GBCGDNIH2_RS00440	COG0302	gtp cyclohydrolase
GBCGDNIH2_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
GBCGDNIH2_RS00485	COG2096	Adenosyltransferase
GBCGDNIH2_RS00495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GBCGDNIH2_RS00500	COG0604	alcohol dehydrogenase
GBCGDNIH2_RS00510	COG0564	pseudouridine synthase activity
GBCGDNIH2_RS00525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GBCGDNIH2_RS00530	COG1091	dTDP-4-dehydrorhamnose reductase activity
GBCGDNIH2_RS00545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GBCGDNIH2_RS00555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GBCGDNIH2_RS00555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GBCGDNIH2_RS00555	COG0506	proline dehydrogenase activity
GBCGDNIH2_RS00570	COG0189	ligase activity
GBCGDNIH2_RS00590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GBCGDNIH2_RS00595	COG1702	phosphate starvation-inducible protein PhoH
GBCGDNIH2_RS00600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GBCGDNIH2_RS00610	COG0729	surface antigen
GBCGDNIH2_RS00625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GBCGDNIH2_RS00640	COG3045	CreA protein
GBCGDNIH2_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBCGDNIH2_RS00650	COG0165	Argininosuccinate lyase
GBCGDNIH2_RS00655	COG0019	diaminopimelate decarboxylase activity
GBCGDNIH2_RS00665	COG2884	Cell division ATP-binding protein ftsE
GBCGDNIH2_RS00695	COG1271	oxidase subunit
GBCGDNIH2_RS00700	COG1294	oxidase, subunit
GBCGDNIH2_RS00705	COG0287	Prephenate dehydrogenase
GBCGDNIH2_RS00710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GBCGDNIH2_RS00720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GBCGDNIH2_RS00735	COG0642	Histidine kinase
GBCGDNIH2_RS00735	COG3850	Histidine kinase
GBCGDNIH2_RS00750	COG1643	Atp-dependent helicase
GBCGDNIH2_RS00765	COG1410	methionine synthase
GBCGDNIH2_RS00765	COG0646	methionine synthase
GBCGDNIH2_RS00770	COG2226	methyltransferase
GBCGDNIH2_RS00780	COG1116	anion transmembrane transporter activity
GBCGDNIH2_RS00785	COG4176	ABC-type proline glycine betaine transport system permease component
GBCGDNIH2_RS00790	COG0756	dUTP diphosphatase activity
GBCGDNIH2_RS00795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GBCGDNIH2_RS00800	COG2226	methyltransferase
GBCGDNIH2_RS00805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GBCGDNIH2_RS00810	COG0268	Binds directly to 16S ribosomal RNA
GBCGDNIH2_RS00815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GBCGDNIH2_RS00820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GBCGDNIH2_RS00840	COG2363	Small membrane protein
GBCGDNIH2_RS00850	COG0625	glutathione transferase activity
GBCGDNIH2_RS00860	COG0523	cobalamin synthesis protein
GBCGDNIH2_RS00870	COG4774	siderophore transport
GBCGDNIH2_RS00880	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBCGDNIH2_RS00880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBCGDNIH2_RS00890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBCGDNIH2_RS00915	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GBCGDNIH2_RS00920	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GBCGDNIH2_RS00925	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GBCGDNIH2_RS00930	COG2205	protein histidine kinase activity
GBCGDNIH2_RS00935	COG0745	RESPONSE REGULATOR receiver
GBCGDNIH2_RS00955	COG2995	paraquat-inducible protein a
GBCGDNIH2_RS00960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GBCGDNIH2_RS00960	COG3008	intermembrane lipid transfer
GBCGDNIH2_RS01000	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS01005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GBCGDNIH2_RS01015	COG0488	(ABC) transporter
GBCGDNIH2_RS01040	COG2853	Lipoprotein
GBCGDNIH2_RS01055	COG2264	protein methyltransferase activity
GBCGDNIH2_RS01065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GBCGDNIH2_RS01070	COG0598	Magnesium transport protein CorA
GBCGDNIH2_RS01075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GBCGDNIH2_RS01095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GBCGDNIH2_RS01100	COG1940	carbohydrate kinase activity
GBCGDNIH2_RS01110	COG1722	exodeoxyribonuclease VII activity
GBCGDNIH2_RS01120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GBCGDNIH2_RS01125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GBCGDNIH2_RS01135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GBCGDNIH2_RS01140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GBCGDNIH2_RS01145	COG0259	pyridoxamine-phosphate oxidase activity
GBCGDNIH2_RS01190	COG0456	acetyltransferase
GBCGDNIH2_RS01195	COG1260	myo-inositol-1-phosphate synthase
GBCGDNIH2_RS01215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBCGDNIH2_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
GBCGDNIH2_RS01245	COG0535	radical SAM domain protein
GBCGDNIH2_RS01255	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS01260	COG0795	lipopolysaccharide-transporting ATPase activity
GBCGDNIH2_RS01275	COG3118	belongs to the thioredoxin family
GBCGDNIH2_RS01280	COG2835	tetraacyldisaccharide 4'-kinase activity
GBCGDNIH2_RS01290	COG0667	Aldo Keto reductase
GBCGDNIH2_RS01305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBCGDNIH2_RS01315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GBCGDNIH2_RS01320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GBCGDNIH2_RS01325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GBCGDNIH2_RS01340	COG0137	argininosuccinate synthase activity
GBCGDNIH2_RS01350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GBCGDNIH2_RS01360	COG3088	subunit of a heme lyase
GBCGDNIH2_RS01365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBCGDNIH2_RS01370	COG1138	Cytochrome C-type biogenesis protein
GBCGDNIH2_RS01375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GBCGDNIH2_RS01380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GBCGDNIH2_RS01405	COG2223	nitrite transmembrane transporter activity
GBCGDNIH2_RS01410	COG1872	DUF167
GBCGDNIH2_RS01425	COG0477	Major facilitator Superfamily
GBCGDNIH2_RS01430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GBCGDNIH2_RS01440	COG0860	N-Acetylmuramoyl-L-alanine amidase
GBCGDNIH2_RS01445	COG1530	ribonuclease E activity
GBCGDNIH2_RS01455	COG3258	Cytochrome c
GBCGDNIH2_RS01485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GBCGDNIH2_RS01490	COG0343	queuine tRNA-ribosyltransferase activity
GBCGDNIH2_RS01495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GBCGDNIH2_RS01500	COG0179	Fumarylacetoacetate (FAA) hydrolase
GBCGDNIH2_RS01510	COG0655	NAD(P)H dehydrogenase (quinone) activity
GBCGDNIH2_RS01515	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS01520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GBCGDNIH2_RS01530	COG3541	Predicted nucleotidyltransferase
GBCGDNIH2_RS01540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBCGDNIH2_RS01545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GBCGDNIH2_RS01560	COG0628	permease
GBCGDNIH2_RS01590	COG0156	8-amino-7-oxononanoate synthase activity
GBCGDNIH2_RS01610	COG0126	phosphoglycerate kinase activity
GBCGDNIH2_RS01620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GBCGDNIH2_RS01635	COG0326	Molecular chaperone. Has ATPase activity
GBCGDNIH2_RS01640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GBCGDNIH2_RS01655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GBCGDNIH2_RS01690	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS01730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GBCGDNIH2_RS01765	COG0688	phosphatidylethanolamine metabolic process
GBCGDNIH2_RS01770	COG1183	phosphatidylcholine synthase activity
GBCGDNIH2_RS01785	COG4993	Dehydrogenase
GBCGDNIH2_RS01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBCGDNIH2_RS01795	COG2010	Cytochrome c
GBCGDNIH2_RS01805	COG0714	Associated with various cellular activities
GBCGDNIH2_RS01840	COG2197	response regulator
GBCGDNIH2_RS01845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GBCGDNIH2_RS01845	COG0662	Cupin 2, conserved barrel domain protein
GBCGDNIH2_RS01860	COG2885	chlorophyll binding
GBCGDNIH2_RS01860	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBCGDNIH2_RS01865	COG2308	Evidence 4 Homologs of previously reported genes of
GBCGDNIH2_RS01880	COG0469	pyruvate kinase activity
GBCGDNIH2_RS01895	COG3750	Belongs to the UPF0335 family
GBCGDNIH2_RS01905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GBCGDNIH2_RS01910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GBCGDNIH2_RS01935	COG0640	Transcriptional regulator
GBCGDNIH2_RS01940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GBCGDNIH2_RS01945	COG0670	Belongs to the BI1 family
GBCGDNIH2_RS01960	COG0436	Aminotransferase
GBCGDNIH2_RS01965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GBCGDNIH2_RS02000	COG1214	PFAM Peptidase M22, glycoprotease
GBCGDNIH2_RS02015	COG4957	zinc ion binding
GBCGDNIH2_RS02030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GBCGDNIH2_RS02035	COG1396	sequence-specific DNA binding
GBCGDNIH2_RS02045	COG1660	Displays ATPase and GTPase activities
GBCGDNIH2_RS02070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GBCGDNIH2_RS02095	COG4133	protoheme IX ABC transporter activity
GBCGDNIH2_RS02100	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GBCGDNIH2_RS02115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GBCGDNIH2_RS02115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GBCGDNIH2_RS02120	COG1105	Belongs to the carbohydrate kinase PfkB family
GBCGDNIH2_RS02125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBCGDNIH2_RS02125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBCGDNIH2_RS02130	COG1609	Transcriptional regulator
GBCGDNIH2_RS02140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GBCGDNIH2_RS02145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GBCGDNIH2_RS02160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GBCGDNIH2_RS02165	COG0497	DNA recombination
GBCGDNIH2_RS02170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GBCGDNIH2_RS02185	COG0849	cell division
GBCGDNIH2_RS02190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GBCGDNIH2_RS02195	COG1181	Belongs to the D-alanine--D-alanine ligase family
GBCGDNIH2_RS02200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GBCGDNIH2_RS02205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GBCGDNIH2_RS02210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GBCGDNIH2_RS02220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GBCGDNIH2_RS02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GBCGDNIH2_RS02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GBCGDNIH2_RS02235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GBCGDNIH2_RS02250	COG0275	rRNA processing
GBCGDNIH2_RS02255	COG2001	Belongs to the MraZ family
GBCGDNIH2_RS02265	COG3023	N-Acetylmuramoyl-L-alanine amidase
GBCGDNIH2_RS02270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GBCGDNIH2_RS02280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBCGDNIH2_RS02295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GBCGDNIH2_RS02300	COG0183	Belongs to the thiolase family
GBCGDNIH2_RS02325	COG0625	glutathione transferase activity
GBCGDNIH2_RS02330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBCGDNIH2_RS02335	COG2226	methyltransferase
GBCGDNIH2_RS02350	COG0590	tRNA wobble adenosine to inosine editing
GBCGDNIH2_RS02355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GBCGDNIH2_RS02360	COG1187	pseudouridine synthase activity
GBCGDNIH2_RS02365	COG0742	ribosomal rna small subunit methyltransferase
GBCGDNIH2_RS02370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBCGDNIH2_RS02370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBCGDNIH2_RS02380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GBCGDNIH2_RS02390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GBCGDNIH2_RS02395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GBCGDNIH2_RS02400	COG0196	riboflavin kinase activity
GBCGDNIH2_RS02415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GBCGDNIH2_RS02430	COG1283	sodium-dependent phosphate transmembrane transporter activity
GBCGDNIH2_RS02435	COG0850	regulation of cytokinetic process
GBCGDNIH2_RS02440	COG2894	cell division
GBCGDNIH2_RS02445	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GBCGDNIH2_RS02465	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS02470	COG1132	(ABC) transporter
GBCGDNIH2_RS02475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GBCGDNIH2_RS02480	COG0242	peptide deformylase activity
GBCGDNIH2_RS02500	COG2224	Isocitrate lyase
GBCGDNIH2_RS02505	COG3800	Transcriptional regulator
GBCGDNIH2_RS02505	COG1396	sequence-specific DNA binding
GBCGDNIH2_RS02515	COG4638	Rieske (2fe-2S)
GBCGDNIH2_RS02525	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GBCGDNIH2_RS02530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GBCGDNIH2_RS02545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GBCGDNIH2_RS02550	COG1230	cation diffusion facilitator family transporter
GBCGDNIH2_RS02555	COG0156	8-amino-7-oxononanoate synthase activity
GBCGDNIH2_RS02560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GBCGDNIH2_RS02565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GBCGDNIH2_RS02580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBCGDNIH2_RS02590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GBCGDNIH2_RS02590	COG0616	signal peptide processing
GBCGDNIH2_RS02595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GBCGDNIH2_RS02600	COG2202	Pas domain
GBCGDNIH2_RS02600	COG2205	protein histidine kinase activity
GBCGDNIH2_RS02605	COG2719	SpoVR family
GBCGDNIH2_RS02610	COG2718	Belongs to the UPF0229 family
GBCGDNIH2_RS02615	COG2766	serine protein kinase
GBCGDNIH2_RS02635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GBCGDNIH2_RS02635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GBCGDNIH2_RS02640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GBCGDNIH2_RS02660	COG2307	Protein conserved in bacteria
GBCGDNIH2_RS02660	COG2308	Evidence 4 Homologs of previously reported genes of
GBCGDNIH2_RS02670	COG0025	NhaP-type Na H and K H
GBCGDNIH2_RS02680	COG1982	Orn Lys Arg decarboxylase major
GBCGDNIH2_RS02700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GBCGDNIH2_RS02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GBCGDNIH2_RS02720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GBCGDNIH2_RS02725	COG0175	sulfate reduction
GBCGDNIH2_RS02730	COG0667	Aldo Keto reductase
GBCGDNIH2_RS02745	COG0513	Belongs to the DEAD box helicase family
GBCGDNIH2_RS02755	COG0297	glycogen (starch) synthase activity
GBCGDNIH2_RS02760	COG1940	carbohydrate kinase activity
GBCGDNIH2_RS02765	COG1116	anion transmembrane transporter activity
GBCGDNIH2_RS02770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBCGDNIH2_RS02785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GBCGDNIH2_RS02790	COG0081	regulation of translation
GBCGDNIH2_RS02795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GBCGDNIH2_RS02800	COG0222	ribosome binding
GBCGDNIH2_RS02805	COG0085	RNA polymerase activity
GBCGDNIH2_RS02810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GBCGDNIH2_RS02815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GBCGDNIH2_RS02820	COG0049	tRNA binding
GBCGDNIH2_RS02825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GBCGDNIH2_RS02830	COG0051	transcription antitermination factor activity, RNA binding
GBCGDNIH2_RS02835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GBCGDNIH2_RS02840	COG0088	Forms part of the polypeptide exit tunnel
GBCGDNIH2_RS02845	COG0089	rRNA binding
GBCGDNIH2_RS02850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GBCGDNIH2_RS02855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GBCGDNIH2_RS02860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GBCGDNIH2_RS02865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GBCGDNIH2_RS02870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GBCGDNIH2_RS02875	COG0255	Belongs to the universal ribosomal protein uL29 family
GBCGDNIH2_RS02880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GBCGDNIH2_RS02885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GBCGDNIH2_RS02890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GBCGDNIH2_RS02895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GBCGDNIH2_RS02900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GBCGDNIH2_RS02905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GBCGDNIH2_RS02910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GBCGDNIH2_RS02915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GBCGDNIH2_RS02920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GBCGDNIH2_RS02925	COG1841	ribosomal large subunit assembly
GBCGDNIH2_RS02930	COG0200	Binds to the 23S rRNA
GBCGDNIH2_RS02935	COG0201	protein transport
GBCGDNIH2_RS02940	COG0563	adenylate kinase activity
GBCGDNIH2_RS02945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GBCGDNIH2_RS02950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GBCGDNIH2_RS02955	COG0202	RNA polymerase activity
GBCGDNIH2_RS02960	COG0203	ribosomal protein L17
GBCGDNIH2_RS02970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GBCGDNIH2_RS02975	COG0564	pseudouridine synthase activity
GBCGDNIH2_RS02990	COG1254	Belongs to the acylphosphatase family
GBCGDNIH2_RS03000	COG0321	lipoyl(octanoyl) transferase activity
GBCGDNIH2_RS03030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GBCGDNIH2_RS03035	COG2226	methyltransferase
GBCGDNIH2_RS03055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GBCGDNIH2_RS03065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBCGDNIH2_RS03070	COG0527	aspartate kinase activity
GBCGDNIH2_RS03080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBCGDNIH2_RS03090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GBCGDNIH2_RS03095	COG0124	histidyl-tRNA synthetase
GBCGDNIH2_RS03100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GBCGDNIH2_RS03105	COG2226	methyltransferase
GBCGDNIH2_RS03110	COG2890	protein-(glutamine-N5) methyltransferase activity
GBCGDNIH2_RS03125	COG5265	(ABC) transporter
GBCGDNIH2_RS03135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GBCGDNIH2_RS03145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GBCGDNIH2_RS03150	COG4974	Belongs to the 'phage' integrase family
GBCGDNIH2_RS03155	COG0825	malonyl-CoA metabolic process
GBCGDNIH2_RS03170	COG0653	protein targeting
GBCGDNIH2_RS03175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GBCGDNIH2_RS03180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GBCGDNIH2_RS03185	COG0494	nUDIX hydrolase
GBCGDNIH2_RS03190	COG1546	Belongs to the CinA family
GBCGDNIH2_RS03190	COG1058	Belongs to the CinA family
GBCGDNIH2_RS03210	COG0484	heat shock protein binding
GBCGDNIH2_RS03245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GBCGDNIH2_RS03265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GBCGDNIH2_RS03295	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GBCGDNIH2_RS03310	COG0297	glycogen (starch) synthase activity
GBCGDNIH2_RS03325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GBCGDNIH2_RS03330	COG1492	cobalamin metabolic process
GBCGDNIH2_RS03395	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GBCGDNIH2_RS03400	COG1797	cobyrinic acid a,c-diamide synthase activity
GBCGDNIH2_RS03405	COG0402	S-adenosylhomocysteine deaminase activity
GBCGDNIH2_RS03415	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GBCGDNIH2_RS03420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GBCGDNIH2_RS03445	COG0308	aminopeptidase N
GBCGDNIH2_RS03455	COG0730	response to heat
GBCGDNIH2_RS03465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GBCGDNIH2_RS03470	COG0450	alkyl hydroperoxide reductase
GBCGDNIH2_RS03485	COG0776	regulation of translation
GBCGDNIH2_RS03490	COG0187	DNA topoisomerase II activity
GBCGDNIH2_RS03495	COG0783	Belongs to the Dps family
GBCGDNIH2_RS03500	COG2171	N-acyltransferase activity
GBCGDNIH2_RS03505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GBCGDNIH2_RS03520	COG0101	tRNA pseudouridine synthase activity
GBCGDNIH2_RS03525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GBCGDNIH2_RS03530	COG0242	peptide deformylase activity
GBCGDNIH2_RS03545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GBCGDNIH2_RS03550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GBCGDNIH2_RS03555	COG1137	ATPase activity
GBCGDNIH2_RS03570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GBCGDNIH2_RS03570	COG0517	IMP dehydrogenase activity
GBCGDNIH2_RS03615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GBCGDNIH2_RS03625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBCGDNIH2_RS03650	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GBCGDNIH2_RS03670	COG0463	Glycosyl transferase, family 2
GBCGDNIH2_RS03675	COG0076	glutamate decarboxylase activity
GBCGDNIH2_RS03680	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS03685	COG0492	ferredoxin-NADP+ reductase activity
GBCGDNIH2_RS03690	COG1522	sequence-specific DNA binding
GBCGDNIH2_RS03700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GBCGDNIH2_RS03705	COG0594	ribonuclease P activity
GBCGDNIH2_RS03710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GBCGDNIH2_RS03715	COG0706	membrane insertase activity
GBCGDNIH2_RS03720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GBCGDNIH2_RS03750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GBCGDNIH2_RS03755	COG1648	precorrin-2 dehydrogenase activity
GBCGDNIH2_RS03755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GBCGDNIH2_RS03810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBCGDNIH2_RS03825	COG2755	lipolytic protein G-D-S-L family
GBCGDNIH2_RS03825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBCGDNIH2_RS03830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBCGDNIH2_RS03835	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS03835	COG1216	Glycosyl transferase, family 2
GBCGDNIH2_RS03840	COG0488	(ABC) transporter
GBCGDNIH2_RS03845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GBCGDNIH2_RS03855	COG1640	4-alpha-glucanotransferase
GBCGDNIH2_RS03860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GBCGDNIH2_RS03865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GBCGDNIH2_RS03875	COG0366	Alpha amylase catalytic
GBCGDNIH2_RS03880	COG0784	Response regulator, receiver
GBCGDNIH2_RS03905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GBCGDNIH2_RS03910	COG2365	Tyrosine phosphatase family
GBCGDNIH2_RS03915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GBCGDNIH2_RS03915	COG0512	Glutamine amidotransferase of anthranilate synthase
GBCGDNIH2_RS03965	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
GBCGDNIH2_RS03975	COG1181	Belongs to the D-alanine--D-alanine ligase family
GBCGDNIH2_RS03990	COG0702	epimerase
GBCGDNIH2_RS04000	COG2154	pterin-4-alpha-carbinolamine dehydratase
GBCGDNIH2_RS04010	COG1229	Formylmethanofuran dehydrogenase subunit A
GBCGDNIH2_RS04015	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
GBCGDNIH2_RS04020	COG2218	PFAM glutamate synthase alpha subunit domain protein
GBCGDNIH2_RS04030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GBCGDNIH2_RS04040	COG1620	l-lactate permease
GBCGDNIH2_RS04045	COG0656	L-ascorbic acid biosynthetic process
GBCGDNIH2_RS04060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GBCGDNIH2_RS04065	COG0318	PFAM AMP-dependent synthetase and ligase
GBCGDNIH2_RS04090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GBCGDNIH2_RS04090	COG2010	Cytochrome c
GBCGDNIH2_RS04095	COG2017	converts alpha-aldose to the beta-anomer
GBCGDNIH2_RS04100	COG2982	Protein involved in outer membrane biogenesis
GBCGDNIH2_RS04105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GBCGDNIH2_RS04110	COG0625	glutathione transferase activity
GBCGDNIH2_RS04115	COG3963	phosphatidate phosphatase activity
GBCGDNIH2_RS04120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GBCGDNIH2_RS04125	COG0793	Belongs to the peptidase S41A family
GBCGDNIH2_RS04130	COG0557	exoribonuclease II activity
GBCGDNIH2_RS04135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBCGDNIH2_RS04140	COG0758	DNA mediated transformation
GBCGDNIH2_RS04145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GBCGDNIH2_RS04150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GBCGDNIH2_RS04160	COG0540	Belongs to the ATCase OTCase family
GBCGDNIH2_RS04165	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS04175	COG0243	molybdopterin cofactor binding
GBCGDNIH2_RS04180	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GBCGDNIH2_RS04180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBCGDNIH2_RS04190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GBCGDNIH2_RS04195	COG0303	'Molybdopterin
GBCGDNIH2_RS04200	COG0315	cyclic pyranopterin monophosphate synthase activity
GBCGDNIH2_RS04205	COG0134	indole-3-glycerol-phosphate synthase activity
GBCGDNIH2_RS04210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GBCGDNIH2_RS04230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GBCGDNIH2_RS04240	COG0149	triose-phosphate isomerase activity
GBCGDNIH2_RS04245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GBCGDNIH2_RS04250	COG0504	CTP synthase activity
GBCGDNIH2_RS04255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GBCGDNIH2_RS04270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GBCGDNIH2_RS04280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GBCGDNIH2_RS04285	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GBCGDNIH2_RS04290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GBCGDNIH2_RS04295	COG2258	MOSC domain
GBCGDNIH2_RS04305	COG4651	solute:proton antiporter activity
GBCGDNIH2_RS04305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GBCGDNIH2_RS04330	COG1597	lipid kinase activity
GBCGDNIH2_RS04340	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GBCGDNIH2_RS04345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GBCGDNIH2_RS04355	COG0564	pseudouridine synthase activity
GBCGDNIH2_RS04370	COG0363	glucosamine-6-phosphate deaminase activity
GBCGDNIH2_RS04375	COG0561	phosphatase activity
GBCGDNIH2_RS04380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GBCGDNIH2_RS04385	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GBCGDNIH2_RS04390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GBCGDNIH2_RS04400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GBCGDNIH2_RS04405	COG3265	gluconokinase activity
GBCGDNIH2_RS04410	COG2847	Copper chaperone PCu(A)C
GBCGDNIH2_RS04415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GBCGDNIH2_RS04425	COG1309	transcriptional regulator
GBCGDNIH2_RS04430	COG0640	Transcriptional regulator
GBCGDNIH2_RS04435	COG0450	alkyl hydroperoxide reductase
GBCGDNIH2_RS04450	COG0730	response to heat
GBCGDNIH2_RS04455	COG0433	COG0433 Predicted ATPase
GBCGDNIH2_RS04465	COG1968	undecaprenyl-diphosphatase activity
GBCGDNIH2_RS04470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GBCGDNIH2_RS04480	COG4988	ABC transporter
GBCGDNIH2_RS04485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GBCGDNIH2_RS04495	COG0765	amino acid transport
GBCGDNIH2_RS04505	COG0514	ATP-dependent DNA helicase (RecQ)
GBCGDNIH2_RS04530	COG4178	(ABC) transporter
GBCGDNIH2_RS04540	COG0247	lactate metabolic process
GBCGDNIH2_RS04545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GBCGDNIH2_RS04545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GBCGDNIH2_RS04555	COG1999	signal sequence binding
GBCGDNIH2_RS04565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GBCGDNIH2_RS04570	COG0142	geranyltranstransferase activity
GBCGDNIH2_RS04575	COG2321	neutral zinc metallopeptidase
GBCGDNIH2_RS04580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GBCGDNIH2_RS04625	COG1201	RNA secondary structure unwinding
GBCGDNIH2_RS04635	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GBCGDNIH2_RS04635	COG1793	dna ligase
GBCGDNIH2_RS04680	COG3620	sequence-specific DNA binding
GBCGDNIH2_RS04760	COG4974	Belongs to the 'phage' integrase family
GBCGDNIH2_RS04940	COG0450	alkyl hydroperoxide reductase
GBCGDNIH2_RS04945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GBCGDNIH2_RS04950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBCGDNIH2_RS04955	COG0573	inorganic phosphate transmembrane transporter activity
GBCGDNIH2_RS04960	COG0581	inorganic phosphate transmembrane transporter activity
GBCGDNIH2_RS04965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBCGDNIH2_RS04975	COG0745	RESPONSE REGULATOR receiver
GBCGDNIH2_RS05020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GBCGDNIH2_RS05025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GBCGDNIH2_RS05045	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS05055	COG0076	glutamate decarboxylase activity
GBCGDNIH2_RS05060	COG0475	glutathione-regulated potassium exporter activity
GBCGDNIH2_RS05065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBCGDNIH2_RS05075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GBCGDNIH2_RS05085	COG0525	valine-tRNA ligase activity
GBCGDNIH2_RS05090	COG0528	UMP kinase activity
GBCGDNIH2_RS05095	COG0233	cytoplasmic translational termination
GBCGDNIH2_RS05110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GBCGDNIH2_RS05115	COG0750	zinc metalloprotease
GBCGDNIH2_RS05120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GBCGDNIH2_RS05130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBCGDNIH2_RS05135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBCGDNIH2_RS05140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBCGDNIH2_RS05145	COG3494	Protein of unknown function (DUF1009)
GBCGDNIH2_RS05150	COG0346	lactoylglutathione lyase activity
GBCGDNIH2_RS05155	COG3106	COG3106 Predicted ATPase
GBCGDNIH2_RS05160	COG3768	UPF0283 membrane protein
GBCGDNIH2_RS05165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GBCGDNIH2_RS05170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBCGDNIH2_RS05175	COG0154	amidase activity
GBCGDNIH2_RS05180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBCGDNIH2_RS05185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GBCGDNIH2_RS05210	COG0436	Aminotransferase
GBCGDNIH2_RS05220	COG2084	Dehydrogenase
GBCGDNIH2_RS05230	COG1473	amidohydrolase
GBCGDNIH2_RS05240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GBCGDNIH2_RS05245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GBCGDNIH2_RS05260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GBCGDNIH2_RS05265	COG0626	cystathionine gamma-synthase activity
GBCGDNIH2_RS05270	COG2897	thiosulfate sulfurtransferase activity
GBCGDNIH2_RS05285	COG3622	Belongs to the hyi family
GBCGDNIH2_RS05290	COG0405	Gamma-glutamyltransferase
GBCGDNIH2_RS05295	COG0792	nuclease activity
GBCGDNIH2_RS05300	COG0606	chelatase, subunit chli
GBCGDNIH2_RS05310	COG1253	flavin adenine dinucleotide binding
GBCGDNIH2_RS05325	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GBCGDNIH2_RS05330	COG2824	Alkylphosphonate utilization operon protein PhnA
GBCGDNIH2_RS05335	COG2943	transferase activity, transferring hexosyl groups
GBCGDNIH2_RS05340	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GBCGDNIH2_RS05350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GBCGDNIH2_RS05355	COG1758	RNA polymerase activity
GBCGDNIH2_RS05365	COG0736	holo-[acyl-carrier-protein] synthase activity
GBCGDNIH2_RS05370	COG0681	Belongs to the peptidase S26 family
GBCGDNIH2_RS05375	COG0571	ribonuclease III activity
GBCGDNIH2_RS05380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GBCGDNIH2_RS05385	COG1381	Involved in DNA repair and RecF pathway recombination
GBCGDNIH2_RS05390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GBCGDNIH2_RS05395	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GBCGDNIH2_RS05420	COG0113	porphobilinogen synthase activity
GBCGDNIH2_RS05425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GBCGDNIH2_RS05430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBCGDNIH2_RS05435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GBCGDNIH2_RS05450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GBCGDNIH2_RS05450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GBCGDNIH2_RS05455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GBCGDNIH2_RS05460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GBCGDNIH2_RS05465	COG0531	amino acid
GBCGDNIH2_RS05480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GBCGDNIH2_RS05485	COG0416	fatty acid biosynthetic process
GBCGDNIH2_RS05490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GBCGDNIH2_RS05495	COG0776	regulation of translation
GBCGDNIH2_RS05520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GBCGDNIH2_RS05520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GBCGDNIH2_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBCGDNIH2_RS05525	COG2205	protein histidine kinase activity
GBCGDNIH2_RS05535	COG1012	belongs to the aldehyde dehydrogenase family
GBCGDNIH2_RS05565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GBCGDNIH2_RS05570	COG1530	ribonuclease E activity
GBCGDNIH2_RS05575	COG0424	maF-like protein
GBCGDNIH2_RS05580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GBCGDNIH2_RS05585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GBCGDNIH2_RS05590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GBCGDNIH2_RS05595	COG0386	Belongs to the glutathione peroxidase family
GBCGDNIH2_RS05610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GBCGDNIH2_RS05615	COG0717	Belongs to the dCTP deaminase family
GBCGDNIH2_RS05640	COG0114	fumarate hydratase activity
GBCGDNIH2_RS05655	COG0579	oxidoreductase
GBCGDNIH2_RS05705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GBCGDNIH2_RS05710	COG3384	dioxygenase
GBCGDNIH2_RS05715	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS05745	COG3846	protein secretion by the type IV secretion system
GBCGDNIH2_RS05760	COG2948	multi-organism process
GBCGDNIH2_RS05795	COG2951	lytic endotransglycosylase activity
GBCGDNIH2_RS05805	COG1686	Belongs to the peptidase S11 family
GBCGDNIH2_RS05820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GBCGDNIH2_RS05830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBCGDNIH2_RS05835	COG0084	hydrolase, TatD family'
GBCGDNIH2_RS05840	COG1234	tRNA 3'-trailer cleavage
GBCGDNIH2_RS05850	COG1360	Flagellar Motor Protein
GBCGDNIH2_RS05865	COG0483	inositol monophosphate 1-phosphatase activity
GBCGDNIH2_RS05870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GBCGDNIH2_RS05890	COG0352	thiamine-phosphate diphosphorylase activity
GBCGDNIH2_RS05895	COG1830	Aldolase
GBCGDNIH2_RS05920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GBCGDNIH2_RS05925	COG3781	membrane
GBCGDNIH2_RS05930	COG1692	metallophosphoesterase
GBCGDNIH2_RS05935	COG0217	transcriptional regulatory protein
GBCGDNIH2_RS05940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GBCGDNIH2_RS05945	COG0632	four-way junction helicase activity
GBCGDNIH2_RS05950	COG0778	Nitroreductase
GBCGDNIH2_RS05955	COG2255	four-way junction helicase activity
GBCGDNIH2_RS05960	COG0824	Thioesterase
GBCGDNIH2_RS05980	COG0823	Involved in the tonB-independent uptake of proteins
GBCGDNIH2_RS05985	COG2885	chlorophyll binding
GBCGDNIH2_RS05995	COG0037	tRNA processing
GBCGDNIH2_RS06000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GBCGDNIH2_RS06010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GBCGDNIH2_RS06015	COG0351	phosphomethylpyrimidine kinase
GBCGDNIH2_RS06015	COG0352	thiamine-phosphate diphosphorylase activity
GBCGDNIH2_RS06030	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GBCGDNIH2_RS06035	COG0405	Gamma-glutamyltransferase
GBCGDNIH2_RS06045	COG3454	Phosphonate metabolism
GBCGDNIH2_RS06065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBCGDNIH2_RS06070	COG0546	phosphoglycolate phosphatase activity
GBCGDNIH2_RS06075	COG1923	regulation of RNA biosynthetic process
GBCGDNIH2_RS06080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GBCGDNIH2_RS06090	COG3956	TIGRFAM MazG family protein
GBCGDNIH2_RS06115	COG0784	Response regulator, receiver
GBCGDNIH2_RS06115	COG4191	Histidine kinase
GBCGDNIH2_RS06135	COG0215	cysteine-tRNA ligase activity
GBCGDNIH2_RS06160	COG1215	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS06165	COG0243	molybdopterin cofactor binding
GBCGDNIH2_RS06185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GBCGDNIH2_RS06195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GBCGDNIH2_RS06195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBCGDNIH2_RS06205	COG0519	Catalyzes the synthesis of GMP from XMP
GBCGDNIH2_RS06205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GBCGDNIH2_RS06240	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBCGDNIH2_RS06250	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS06260	COG1733	regulation of RNA biosynthetic process
GBCGDNIH2_RS06275	COG0596	Alpha beta hydrolase
GBCGDNIH2_RS06285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GBCGDNIH2_RS06300	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS06320	COG2367	Beta-lactamase
GBCGDNIH2_RS06350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GBCGDNIH2_RS06370	COG0148	phosphopyruvate hydratase activity
GBCGDNIH2_RS06380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GBCGDNIH2_RS06385	COG0022	dehydrogenase e1 component
GBCGDNIH2_RS06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBCGDNIH2_RS06390	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBCGDNIH2_RS06400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GBCGDNIH2_RS06405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GBCGDNIH2_RS06425	COG1546	Belongs to the CinA family
GBCGDNIH2_RS06430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GBCGDNIH2_RS06435	COG0741	lytic transglycosylase activity
GBCGDNIH2_RS06440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GBCGDNIH2_RS06445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GBCGDNIH2_RS06465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GBCGDNIH2_RS06470	COG1131	(ABC) transporter
GBCGDNIH2_RS06490	COG1051	belongs to the nudix hydrolase family
GBCGDNIH2_RS06495	COG2223	nitrite transmembrane transporter activity
GBCGDNIH2_RS06500	COG3038	cytochrome b561
GBCGDNIH2_RS06505	COG0803	Belongs to the bacterial solute-binding protein 9 family
GBCGDNIH2_RS06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GBCGDNIH2_RS06515	COG1121	(ABC) transporter
GBCGDNIH2_RS06525	COG0735	belongs to the Fur family
GBCGDNIH2_RS06535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GBCGDNIH2_RS06540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GBCGDNIH2_RS06560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GBCGDNIH2_RS06565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GBCGDNIH2_RS06570	COG0629	single-stranded DNA binding
GBCGDNIH2_RS06575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GBCGDNIH2_RS06585	COG2204	response regulator
GBCGDNIH2_RS06615	COG0277	FAD linked oxidase domain protein
GBCGDNIH2_RS06625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GBCGDNIH2_RS06650	COG0668	transmembrane transport
GBCGDNIH2_RS06660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GBCGDNIH2_RS06665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GBCGDNIH2_RS06690	COG2351	hydroxyisourate hydrolase activity
GBCGDNIH2_RS06700	COG1988	membrane-bound metal-dependent
GBCGDNIH2_RS06710	COG1862	Preprotein translocase
GBCGDNIH2_RS06725	COG4269	membrane
GBCGDNIH2_RS06730	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GBCGDNIH2_RS06735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GBCGDNIH2_RS06740	COG0805	protein transport
GBCGDNIH2_RS06745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GBCGDNIH2_RS06750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GBCGDNIH2_RS06755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GBCGDNIH2_RS06760	COG1994	Peptidase M50
GBCGDNIH2_RS06775	COG0018	arginyl-trna synthetase
GBCGDNIH2_RS06780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GBCGDNIH2_RS06790	COG0708	Exodeoxyribonuclease III
GBCGDNIH2_RS06795	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS06800	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS06815	COG1116	anion transmembrane transporter activity
GBCGDNIH2_RS06815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBCGDNIH2_RS06835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GBCGDNIH2_RS06840	COG1845	cytochrome c oxidase, subunit III
GBCGDNIH2_RS06850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GBCGDNIH2_RS06855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GBCGDNIH2_RS06860	COG0052	Belongs to the universal ribosomal protein uS2 family
GBCGDNIH2_RS06875	COG1136	(ABC) transporter
GBCGDNIH2_RS06885	COG0442	prolyl-tRNA aminoacylation
GBCGDNIH2_RS06900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GBCGDNIH2_RS06905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GBCGDNIH2_RS06905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GBCGDNIH2_RS06910	COG1007	ATP synthesis coupled electron transport
GBCGDNIH2_RS06925	COG0713	ATP synthesis coupled electron transport
GBCGDNIH2_RS06935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBCGDNIH2_RS06940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GBCGDNIH2_RS06955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GBCGDNIH2_RS06960	COG0649	NAD binding
GBCGDNIH2_RS06965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBCGDNIH2_RS06970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBCGDNIH2_RS06975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBCGDNIH2_RS07020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GBCGDNIH2_RS07025	COG0740	serine-type endopeptidase activity
GBCGDNIH2_RS07030	COG0544	peptidyl-prolyl cis-trans isomerase activity
GBCGDNIH2_RS07040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GBCGDNIH2_RS07040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GBCGDNIH2_RS07070	COG3387	PFAM Glycoside hydrolase 15-related
GBCGDNIH2_RS07075	COG0513	Belongs to the DEAD box helicase family
GBCGDNIH2_RS07080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GBCGDNIH2_RS07090	COG2151	metal-sulfur cluster biosynthetic enzyme
GBCGDNIH2_RS07095	COG0822	iron-sulfur transferase activity
GBCGDNIH2_RS07100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GBCGDNIH2_RS07105	COG0719	Fe-S assembly protein
GBCGDNIH2_RS07110	COG0396	ATPase activity
GBCGDNIH2_RS07115	COG0719	Fe-S assembly protein
GBCGDNIH2_RS07170	COG2733	membrane
GBCGDNIH2_RS07185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GBCGDNIH2_RS07190	COG1957	nucleoside hydrolase
GBCGDNIH2_RS07200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GBCGDNIH2_RS07225	COG0596	Alpha beta hydrolase
GBCGDNIH2_RS07230	COG0604	alcohol dehydrogenase
GBCGDNIH2_RS07230	COG3321	synthase
GBCGDNIH2_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
GBCGDNIH2_RS07240	COG1970	mechanosensitive ion channel activity
GBCGDNIH2_RS07245	COG0516	GMP reductase activity
GBCGDNIH2_RS07245	COG0517	IMP dehydrogenase activity
GBCGDNIH2_RS07255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GBCGDNIH2_RS07265	COG0254	rRNA binding
GBCGDNIH2_RS07305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GBCGDNIH2_RS07310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GBCGDNIH2_RS07315	COG0538	isocitrate dehydrogenase activity
GBCGDNIH2_RS07320	COG0412	Dienelactone hydrolase
GBCGDNIH2_RS07330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GBCGDNIH2_RS07335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GBCGDNIH2_RS07340	COG1518	maintenance of DNA repeat elements
GBCGDNIH2_RS07355	COG1857	crispr-associated protein
GBCGDNIH2_RS07370	COG1203	CRISPR-associated helicase, Cas3
GBCGDNIH2_RS07385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GBCGDNIH2_RS07390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GBCGDNIH2_RS07425	COG5328	Belongs to the UPF0262 family
GBCGDNIH2_RS07430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GBCGDNIH2_RS07455	COG1494	fructose-1,6-bisphosphatase
GBCGDNIH2_RS07460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GBCGDNIH2_RS07460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GBCGDNIH2_RS07475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBCGDNIH2_RS07540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GBCGDNIH2_RS07545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GBCGDNIH2_RS07545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBCGDNIH2_RS07565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GBCGDNIH2_RS07585	COG1136	(ABC) transporter
GBCGDNIH2_RS07630	COG3243	poly(R)-hydroxyalkanoic acid synthase
GBCGDNIH2_RS07640	COG0436	Aminotransferase
GBCGDNIH2_RS07665	COG0741	lytic transglycosylase activity
GBCGDNIH2_RS07675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GBCGDNIH2_RS07675	COG3153	acetyltransferase
GBCGDNIH2_RS07680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBCGDNIH2_RS07705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GBCGDNIH2_RS07720	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GBCGDNIH2_RS07725	COG0463	Glycosyl transferase, family 2
GBCGDNIH2_RS07735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GBCGDNIH2_RS07740	COG1127	ABC transporter
GBCGDNIH2_RS07745	COG3008	intermembrane lipid transfer
GBCGDNIH2_RS07745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GBCGDNIH2_RS07760	COG1309	transcriptional regulator
GBCGDNIH2_RS07785	COG0484	heat shock protein binding
GBCGDNIH2_RS07800	COG0463	Glycosyl transferase, family 2
GBCGDNIH2_RS07810	COG0772	Belongs to the SEDS family
GBCGDNIH2_RS07815	COG0768	penicillin binding
GBCGDNIH2_RS07860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GBCGDNIH2_RS07865	COG0440	acetolactate synthase activity
GBCGDNIH2_RS07870	COG0028	Belongs to the TPP enzyme family
GBCGDNIH2_RS07875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GBCGDNIH2_RS07880	COG3830	Belongs to the UPF0237 family
GBCGDNIH2_RS07880	COG0560	Phosphoserine phosphatase
GBCGDNIH2_RS07920	COG0489	protein tyrosine kinase activity
GBCGDNIH2_RS07925	COG4251	negative regulation of phosphorylation
GBCGDNIH2_RS07950	COG0552	protein localization to endoplasmic reticulum
GBCGDNIH2_RS07955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GBCGDNIH2_RS07960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GBCGDNIH2_RS07975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GBCGDNIH2_RS07980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GBCGDNIH2_RS07985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GBCGDNIH2_RS07990	COG0072	phenylalanine-tRNA ligase activity
GBCGDNIH2_RS07990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBCGDNIH2_RS07995	COG0481	GTPase activity
GBCGDNIH2_RS08060	COG1061	Type III restriction enzyme res subunit
GBCGDNIH2_RS08065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBCGDNIH2_RS08115	COG2274	protein secretion by the type I secretion system
GBCGDNIH2_RS08135	COG3754	Rhamnan synthesis protein F
GBCGDNIH2_RS08145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GBCGDNIH2_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
GBCGDNIH2_RS08160	COG1216	Glycosyl transferase, family 2
GBCGDNIH2_RS08165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GBCGDNIH2_RS08175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBCGDNIH2_RS08185	COG0523	cobalamin synthesis protein
GBCGDNIH2_RS08445	COG2910	NAD(P)H-binding
GBCGDNIH2_RS08450	COG0753	catalase activity
GBCGDNIH2_RS08490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GBCGDNIH2_RS08505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GBCGDNIH2_RS08525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GBCGDNIH2_RS08540	COG1404	Belongs to the peptidase S8 family
GBCGDNIH2_RS08550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GBCGDNIH2_RS08550	COG1918	ferrous iron import across plasma membrane
GBCGDNIH2_RS08565	COG2326	polyphosphate kinase activity
GBCGDNIH2_RS08580	COG2353	YceI-like domain
GBCGDNIH2_RS08585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GBCGDNIH2_RS08595	COG1132	(ABC) transporter
GBCGDNIH2_RS08600	COG0617	tRNA 3'-terminal CCA addition
GBCGDNIH2_RS08615	COG2233	PERMEase
GBCGDNIH2_RS08625	COG0714	Associated with various cellular activities
GBCGDNIH2_RS08645	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GBCGDNIH2_RS08680	COG0138	bifunctional purine biosynthesis protein purh
GBCGDNIH2_RS08700	COG1686	Belongs to the peptidase S11 family
GBCGDNIH2_RS08705	COG1252	NADH dehydrogenase
GBCGDNIH2_RS08710	COG0024	Methionine aminopeptidase
GBCGDNIH2_RS08725	COG2205	protein histidine kinase activity
GBCGDNIH2_RS08730	COG0861	Integral membrane protein TerC family
GBCGDNIH2_RS08735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GBCGDNIH2_RS08775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GBCGDNIH2_RS08780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GBCGDNIH2_RS08790	COG0047	phosphoribosylformylglycinamidine synthase activity
GBCGDNIH2_RS08795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GBCGDNIH2_RS08800	COG0271	Belongs to the BolA IbaG family
GBCGDNIH2_RS08805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GBCGDNIH2_RS08810	COG1959	2 iron, 2 sulfur cluster binding
GBCGDNIH2_RS08815	COG1017	nitric oxide dioxygenase activity
GBCGDNIH2_RS08815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GBCGDNIH2_RS08825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GBCGDNIH2_RS08830	COG0473	3-isopropylmalate dehydrogenase activity
GBCGDNIH2_RS08835	COG0066	3-isopropylmalate dehydratase activity
GBCGDNIH2_RS08840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GBCGDNIH2_RS08845	COG0335	large ribosomal subunit rRNA binding
GBCGDNIH2_RS08850	COG0336	Belongs to the RNA methyltransferase TrmD family
GBCGDNIH2_RS08855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GBCGDNIH2_RS08860	COG0228	four-way junction DNA binding
GBCGDNIH2_RS08890	COG1280	lysine exporter protein (LysE YggA)
GBCGDNIH2_RS08895	COG1203	CRISPR-associated helicase, Cas3
GBCGDNIH2_RS08925	COG1518	maintenance of DNA repeat elements
GBCGDNIH2_RS08940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GBCGDNIH2_RS08945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GBCGDNIH2_RS08950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GBCGDNIH2_RS08955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GBCGDNIH2_RS08965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GBCGDNIH2_RS08970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GBCGDNIH2_RS08975	COG0799	negative regulation of ribosome biogenesis
GBCGDNIH2_RS08980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GBCGDNIH2_RS08985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GBCGDNIH2_RS08990	COG4942	peptidase
GBCGDNIH2_RS08995	COG0793	Belongs to the peptidase S41A family
GBCGDNIH2_RS09000	COG0494	nUDIX hydrolase
GBCGDNIH2_RS09010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GBCGDNIH2_RS09030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GBCGDNIH2_RS09035	COG0408	coproporphyrinogen oxidase activity
GBCGDNIH2_RS09040	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS09050	COG0243	molybdopterin cofactor binding
GBCGDNIH2_RS09060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GBCGDNIH2_RS09070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBCGDNIH2_RS09075	COG3707	response regulator
GBCGDNIH2_RS09080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GBCGDNIH2_RS09110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GBCGDNIH2_RS09135	COG4221	oxidoreductase activity
GBCGDNIH2_RS09140	COG2326	polyphosphate kinase activity
GBCGDNIH2_RS09170	COG2011	ABC-type metal ion transport system permease component
GBCGDNIH2_RS09185	COG0297	glycogen (starch) synthase activity
GBCGDNIH2_RS09185	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS09200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GBCGDNIH2_RS09205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GBCGDNIH2_RS09210	COG1459	type II secretion system
GBCGDNIH2_RS09215	COG4970	Tfp pilus assembly protein FimT
GBCGDNIH2_RS09250	COG1450	Type ii and iii secretion system protein
GBCGDNIH2_RS09285	COG0300	oxidoreductase activity
GBCGDNIH2_RS09300	COG2226	methyltransferase
GBCGDNIH2_RS09320	COG0596	Alpha beta hydrolase
GBCGDNIH2_RS09335	COG1090	epimerase
GBCGDNIH2_RS09380	COG2226	methyltransferase
GBCGDNIH2_RS09445	COG0542	response to heat
GBCGDNIH2_RS09455	COG2094	Belongs to the DNA glycosylase MPG family
GBCGDNIH2_RS09460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GBCGDNIH2_RS09460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GBCGDNIH2_RS09475	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GBCGDNIH2_RS09480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GBCGDNIH2_RS09505	COG1024	Enoyl-CoA hydratase
GBCGDNIH2_RS09515	COG0741	lytic transglycosylase activity
GBCGDNIH2_RS09550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBCGDNIH2_RS09560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBCGDNIH2_RS09570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GBCGDNIH2_RS09615	COG0784	Response regulator, receiver
GBCGDNIH2_RS09615	COG2205	protein histidine kinase activity
GBCGDNIH2_RS09625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GBCGDNIH2_RS09635	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS09650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GBCGDNIH2_RS09660	COG0668	transmembrane transport
GBCGDNIH2_RS09665	COG0175	sulfate reduction
GBCGDNIH2_RS09670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GBCGDNIH2_RS09680	COG1573	uracil-dna glycosylase
GBCGDNIH2_RS09690	COG4716	Myosin-crossreactive antigen
GBCGDNIH2_RS09695	COG0521	Mo-molybdopterin cofactor biosynthetic process
GBCGDNIH2_RS09720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GBCGDNIH2_RS09755	COG1196	nuclear chromosome segregation
GBCGDNIH2_RS09770	COG0356	it plays a direct role in the translocation of protons across the membrane
GBCGDNIH2_RS09775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GBCGDNIH2_RS09780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GBCGDNIH2_RS09785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GBCGDNIH2_RS09810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GBCGDNIH2_RS09815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GBCGDNIH2_RS09820	COG0328	RNA-DNA hybrid ribonuclease activity
GBCGDNIH2_RS09825	COG0678	peroxiredoxin activity
GBCGDNIH2_RS09830	COG1678	Uncharacterized ACR, COG1678
GBCGDNIH2_RS09840	COG0167	dihydroorotate dehydrogenase activity
GBCGDNIH2_RS09855	COG0435	Glutathione S-transferase
GBCGDNIH2_RS09870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GBCGDNIH2_RS09885	COG4303	Ethanolamine ammonia lyase large subunit
GBCGDNIH2_RS09890	COG4302	ethanolamine ammonia-lyase activity
GBCGDNIH2_RS09895	COG0531	amino acid
GBCGDNIH2_RS09905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GBCGDNIH2_RS09910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GBCGDNIH2_RS09915	COG4208	sulfate ABC transporter
GBCGDNIH2_RS09920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GBCGDNIH2_RS09950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GBCGDNIH2_RS09960	COG3851	Histidine kinase
GBCGDNIH2_RS09975	COG3474	cytochrome
GBCGDNIH2_RS10005	COG1131	(ABC) transporter
GBCGDNIH2_RS10010	COG1129	ABC transporter
GBCGDNIH2_RS10010	COG0842	Transport permease protein
GBCGDNIH2_RS10050	COG0535	radical SAM domain protein
GBCGDNIH2_RS10060	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GBCGDNIH2_RS10065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GBCGDNIH2_RS10075	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS10095	COG3383	formate dehydrogenase (NAD+) activity
GBCGDNIH2_RS10100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GBCGDNIH2_RS10115	COG0129	dihydroxy-acid dehydratase activity
GBCGDNIH2_RS10120	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS10125	COG4774	siderophore transport
GBCGDNIH2_RS10135	COG0482	sulfurtransferase activity
GBCGDNIH2_RS10145	COG1104	cysteine desulfurase activity
GBCGDNIH2_RS10150	COG1104	cysteine desulfurase activity
GBCGDNIH2_RS10155	COG2945	thiolester hydrolase activity
GBCGDNIH2_RS10160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GBCGDNIH2_RS10165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GBCGDNIH2_RS10170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GBCGDNIH2_RS10185	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GBCGDNIH2_RS10190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GBCGDNIH2_RS10195	COG0531	amino acid
GBCGDNIH2_RS10200	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GBCGDNIH2_RS10220	COG0439	Biotin carboxylase
GBCGDNIH2_RS10225	COG0511	ligase activity, forming carbon-carbon bonds
GBCGDNIH2_RS10230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GBCGDNIH2_RS10235	COG2104	thiamine diphosphate biosynthetic process
GBCGDNIH2_RS10240	COG2022	thiamine diphosphate biosynthetic process
GBCGDNIH2_RS10275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBCGDNIH2_RS10275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBCGDNIH2_RS10280	COG1741	Belongs to the pirin family
GBCGDNIH2_RS10295	COG0753	catalase activity
GBCGDNIH2_RS10305	COG0745	RESPONSE REGULATOR receiver
GBCGDNIH2_RS10310	COG2205	protein histidine kinase activity
GBCGDNIH2_RS10325	COG2040	homocysteine
GBCGDNIH2_RS10335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GBCGDNIH2_RS10340	COG1215	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS10345	COG1562	ergosterol biosynthetic process
GBCGDNIH2_RS10350	COG1562	ergosterol biosynthetic process
GBCGDNIH2_RS10365	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS10380	COG4172	Belongs to the ABC transporter superfamily
GBCGDNIH2_RS10385	COG4239	(ABC) transporter, permease
GBCGDNIH2_RS10390	COG4174	ABC transporter (Permease)
GBCGDNIH2_RS10395	COG4166	transmembrane transport
GBCGDNIH2_RS10405	COG3474	cytochrome
GBCGDNIH2_RS10425	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GBCGDNIH2_RS10430	COG1396	sequence-specific DNA binding
GBCGDNIH2_RS10440	COG0745	RESPONSE REGULATOR receiver
GBCGDNIH2_RS10460	COG0492	ferredoxin-NADP+ reductase activity
GBCGDNIH2_RS10465	COG0802	atpase or kinase
GBCGDNIH2_RS10470	COG3178	'Phosphotransferase
GBCGDNIH2_RS10475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GBCGDNIH2_RS10485	COG1074	ATP-dependent DNA helicase activity
GBCGDNIH2_RS10500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GBCGDNIH2_RS10505	COG0159	tryptophan synthase activity
GBCGDNIH2_RS10510	COG0133	tryptophan synthase activity
GBCGDNIH2_RS10515	COG0281	malic enzyme
GBCGDNIH2_RS10520	COG0135	phosphoribosylanthranilate isomerase activity
GBCGDNIH2_RS10535	COG0776	regulation of translation
GBCGDNIH2_RS10540	COG0616	signal peptide processing
GBCGDNIH2_RS10545	COG0539	negative regulation of cytoplasmic translation
GBCGDNIH2_RS10550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GBCGDNIH2_RS10555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GBCGDNIH2_RS10580	COG2132	Multicopper oxidase
GBCGDNIH2_RS10600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GBCGDNIH2_RS10610	COG0628	permease
GBCGDNIH2_RS10615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GBCGDNIH2_RS10620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GBCGDNIH2_RS10625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GBCGDNIH2_RS10630	COG0105	UTP biosynthetic process
GBCGDNIH2_RS10635	COG0488	(ABC) transporter
GBCGDNIH2_RS10655	COG0129	dihydroxy-acid dehydratase activity
GBCGDNIH2_RS10660	COG0800	Aldolase
GBCGDNIH2_RS10670	COG2983	Belongs to the UPF0260 family
GBCGDNIH2_RS10680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GBCGDNIH2_RS10680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GBCGDNIH2_RS10690	COG0473	3-isopropylmalate dehydrogenase activity
GBCGDNIH2_RS10710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GBCGDNIH2_RS10720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GBCGDNIH2_RS10725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GBCGDNIH2_RS10740	COG4974	Belongs to the 'phage' integrase family
GBCGDNIH2_RS10750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GBCGDNIH2_RS10755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GBCGDNIH2_RS10765	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBCGDNIH2_RS10780	COG0045	succinate-CoA ligase (ADP-forming) activity
GBCGDNIH2_RS10785	COG0039	L-malate dehydrogenase activity
GBCGDNIH2_RS10790	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GBCGDNIH2_RS10805	COG0477	Major facilitator Superfamily
GBCGDNIH2_RS10815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GBCGDNIH2_RS10820	COG1053	succinate dehydrogenase
GBCGDNIH2_RS10835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GBCGDNIH2_RS10845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GBCGDNIH2_RS10850	COG1763	Mo-molybdopterin cofactor biosynthetic process
GBCGDNIH2_RS10860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GBCGDNIH2_RS10865	COG0314	molybdopterin synthase activity
GBCGDNIH2_RS10875	COG2217	Heavy metal translocating P-type atpase
GBCGDNIH2_RS10880	COG0789	Transcriptional regulator
GBCGDNIH2_RS10890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GBCGDNIH2_RS10900	COG2086	electron transfer activity
GBCGDNIH2_RS10920	COG0574	Belongs to the PEP-utilizing enzyme family
GBCGDNIH2_RS10920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBCGDNIH2_RS10925	COG0751	glycine-tRNA ligase activity
GBCGDNIH2_RS10940	COG0752	glycyl-tRNA synthetase alpha subunit
GBCGDNIH2_RS10955	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS10960	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GBCGDNIH2_RS10965	COG1657	PFAM Prenyltransferase squalene oxidase
GBCGDNIH2_RS10970	COG0784	Response regulator, receiver
GBCGDNIH2_RS10970	COG4191	Histidine kinase
GBCGDNIH2_RS10980	COG0174	glutamine synthetase
GBCGDNIH2_RS10985	COG0069	glutamate synthase activity
GBCGDNIH2_RS10990	COG2218	PFAM glutamate synthase alpha subunit domain protein
GBCGDNIH2_RS10995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GBCGDNIH2_RS11010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GBCGDNIH2_RS11015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GBCGDNIH2_RS11020	COG2223	nitrite transmembrane transporter activity
GBCGDNIH2_RS11030	COG1217	gtp-binding protein TYPA
GBCGDNIH2_RS11050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GBCGDNIH2_RS11055	COG4149	molybdate abc transporter
GBCGDNIH2_RS11060	COG0725	ABC transporter, periplasmic molybdate-binding protein
GBCGDNIH2_RS11070	COG1674	ftsk spoiiie
GBCGDNIH2_RS11075	COG1902	pentaerythritol trinitrate reductase activity
GBCGDNIH2_RS11085	COG1566	PFAM secretion protein HlyD family protein
GBCGDNIH2_RS11095	COG1289	transmembrane transporter activity
GBCGDNIH2_RS11100	COG1846	Transcriptional regulator
GBCGDNIH2_RS11105	COG0004	ammonium transporteR
GBCGDNIH2_RS11110	COG0347	Belongs to the P(II) protein family
GBCGDNIH2_RS11115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GBCGDNIH2_RS11140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GBCGDNIH2_RS11145	COG0237	dephospho-CoA kinase activity
GBCGDNIH2_RS11150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GBCGDNIH2_RS11185	COG1216	Glycosyl transferase, family 2
GBCGDNIH2_RS11185	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS11205	COG0235	Class ii aldolase
GBCGDNIH2_RS11215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GBCGDNIH2_RS11225	COG0829	nickel cation binding
GBCGDNIH2_RS11230	COG0831	urea catabolic process
GBCGDNIH2_RS11235	COG0832	Belongs to the urease beta subunit family
GBCGDNIH2_RS11240	COG0804	urea catabolic process
GBCGDNIH2_RS11250	COG0830	nickel cation binding
GBCGDNIH2_RS11255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GBCGDNIH2_RS11265	COG1322	Protein conserved in bacteria
GBCGDNIH2_RS11270	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS11275	COG0531	amino acid
GBCGDNIH2_RS11295	COG1199	ATP-dependent helicase activity
GBCGDNIH2_RS11310	COG1278	Cold shock
GBCGDNIH2_RS11315	COG0459	protein refolding
GBCGDNIH2_RS11320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GBCGDNIH2_RS11325	COG5425	PFAM Usg family protein
GBCGDNIH2_RS11335	COG1612	heme a metabolic process
GBCGDNIH2_RS11340	COG0312	modulator of DNA gyrase
GBCGDNIH2_RS11360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GBCGDNIH2_RS11380	COG0006	proline dipeptidase activity
GBCGDNIH2_RS11390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GBCGDNIH2_RS11395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GBCGDNIH2_RS11415	COG0009	L-threonylcarbamoyladenylate synthase
GBCGDNIH2_RS11420	COG1218	3'(2'),5'-bisphosphate nucleotidase
GBCGDNIH2_RS11425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GBCGDNIH2_RS11440	COG0194	GDP metabolic process
GBCGDNIH2_RS11450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GBCGDNIH2_RS11455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBCGDNIH2_RS11460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBCGDNIH2_RS11470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GBCGDNIH2_RS11475	COG0360	Binds together with S18 to 16S ribosomal RNA
GBCGDNIH2_RS11480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GBCGDNIH2_RS11485	COG0359	binds to the 23S rRNA
GBCGDNIH2_RS11490	COG0305	Participates in initiation and elongation during chromosome replication
GBCGDNIH2_RS11495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GBCGDNIH2_RS11500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GBCGDNIH2_RS11510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GBCGDNIH2_RS11530	COG0556	nucleotide-excision repair
GBCGDNIH2_RS11540	COG0322	excinuclease ABC activity
GBCGDNIH2_RS11550	COG0140	phosphoribosyl-ATP diphosphatase activity
GBCGDNIH2_RS11555	COG0107	imidazoleglycerol-phosphate synthase activity
GBCGDNIH2_RS11560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GBCGDNIH2_RS11570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GBCGDNIH2_RS11580	COG0131	Imidazoleglycerol-phosphate dehydratase
GBCGDNIH2_RS11585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GBCGDNIH2_RS11590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GBCGDNIH2_RS11605	COG1846	Transcriptional regulator
GBCGDNIH2_RS11610	COG0745	RESPONSE REGULATOR receiver
GBCGDNIH2_RS11625	COG1663	tetraacyldisaccharide 4'-kinase activity
GBCGDNIH2_RS11630	COG1519	Transferase
GBCGDNIH2_RS11635	COG2121	Domain of unknown function (DUF374)
GBCGDNIH2_RS11650	COG1597	lipid kinase activity
GBCGDNIH2_RS11675	COG0612	Peptidase, M16
GBCGDNIH2_RS11680	COG0312	modulator of DNA gyrase
GBCGDNIH2_RS11695	COG0109	protoheme IX farnesyltransferase activity
GBCGDNIH2_RS11700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GBCGDNIH2_RS11705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GBCGDNIH2_RS11705	COG1565	acr, cog1565
GBCGDNIH2_RS11710	COG2226	methyltransferase
GBCGDNIH2_RS11715	COG1278	Cold shock
GBCGDNIH2_RS11730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GBCGDNIH2_RS11735	COG0235	Class ii aldolase
GBCGDNIH2_RS11740	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GBCGDNIH2_RS11745	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GBCGDNIH2_RS11755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GBCGDNIH2_RS11775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GBCGDNIH2_RS11780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GBCGDNIH2_RS11785	COG2137	regulation of response to DNA damage stimulus
GBCGDNIH2_RS11795	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GBCGDNIH2_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
GBCGDNIH2_RS11810	COG0277	FAD linked oxidase domain protein
GBCGDNIH2_RS11815	COG0546	phosphoglycolate phosphatase activity
GBCGDNIH2_RS11815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GBCGDNIH2_RS11830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GBCGDNIH2_RS11845	COG0505	Belongs to the CarA family
GBCGDNIH2_RS11850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GBCGDNIH2_RS11855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GBCGDNIH2_RS11860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GBCGDNIH2_RS11865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GBCGDNIH2_RS11870	COG0477	Major facilitator Superfamily
GBCGDNIH2_RS11885	COG1160	GTP binding
GBCGDNIH2_RS11900	COG1570	exodeoxyribonuclease VII activity
GBCGDNIH2_RS11905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBCGDNIH2_RS11910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBCGDNIH2_RS11915	COG1116	anion transmembrane transporter activity
GBCGDNIH2_RS11935	COG0602	queuosine metabolic process
GBCGDNIH2_RS11960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GBCGDNIH2_RS11980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GBCGDNIH2_RS11985	COG0406	alpha-ribazole phosphatase activity
GBCGDNIH2_RS11990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GBCGDNIH2_RS11995	COG0193	aminoacyl-tRNA hydrolase activity
GBCGDNIH2_RS12000	COG0012	GTP binding
GBCGDNIH2_RS12025	COG2353	YceI-like domain
GBCGDNIH2_RS12040	COG0247	lactate metabolic process
GBCGDNIH2_RS12050	COG1139	Iron-sulfur cluster binding protein
GBCGDNIH2_RS12065	COG4191	Histidine kinase
GBCGDNIH2_RS12065	COG0784	Response regulator, receiver
GBCGDNIH2_RS12070	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GBCGDNIH2_RS12080	COG0588	phosphoglycerate mutase activity
GBCGDNIH2_RS12085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GBCGDNIH2_RS12090	COG0583	DNA-binding transcription factor activity
GBCGDNIH2_RS12095	COG1132	(ABC) transporter
GBCGDNIH2_RS12100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GBCGDNIH2_RS12105	COG0297	glycogen (starch) synthase activity
GBCGDNIH2_RS12110	COG3158	transport of potassium into the cell
GBCGDNIH2_RS12165	COG1064	alcohol dehydrogenase
GBCGDNIH2_RS12170	COG2084	Dehydrogenase
GBCGDNIH2_RS12180	COG0028	Belongs to the TPP enzyme family
GBCGDNIH2_RS12190	COG1185	polyribonucleotide nucleotidyltransferase activity
GBCGDNIH2_RS12195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GBCGDNIH2_RS12200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GBCGDNIH2_RS12215	COG4953	penicillin-binding protein 1C
GBCGDNIH2_RS12235	COG0204	Acyl-transferase
GBCGDNIH2_RS12235	COG0318	PFAM AMP-dependent synthetase and ligase
GBCGDNIH2_RS12245	COG0778	Nitroreductase
GBCGDNIH2_RS12250	COG5002	protein histidine kinase activity
GBCGDNIH2_RS12260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GBCGDNIH2_RS12280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GBCGDNIH2_RS12285	COG0746	molybdenum cofactor guanylyltransferase activity
GBCGDNIH2_RS12290	COG0657	acetylesterase activity
GBCGDNIH2_RS12305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GBCGDNIH2_RS12340	COG4264	IucA IucC family
GBCGDNIH2_RS12345	COG2814	Major facilitator Superfamily
GBCGDNIH2_RS12375	COG0649	NAD binding
GBCGDNIH2_RS12380	COG3260	NADH ubiquinone oxidoreductase 20
GBCGDNIH2_RS12395	COG1216	Glycosyl transferase, family 2
GBCGDNIH2_RS12395	COG0438	transferase activity, transferring glycosyl groups
GBCGDNIH2_RS12400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GBCGDNIH2_RS12405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GBCGDNIH2_RS12420	COG0779	Required for maturation of 30S ribosomal subunits
GBCGDNIH2_RS12430	COG0628	permease
GBCGDNIH2_RS12435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GBCGDNIH2_RS12440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GBCGDNIH2_RS12445	COG3394	polysaccharide catabolic process
GBCGDNIH2_RS12450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GBCGDNIH2_RS12465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GBCGDNIH2_RS12475	COG0535	radical SAM domain protein
GBCGDNIH2_RS12480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GBCGDNIH2_RS12485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GBCGDNIH2_RS12490	COG0728	peptidoglycan biosynthetic process
GBCGDNIH2_RS12510	COG0058	SHG alpha-glucan phosphorylase activity
GBCGDNIH2_RS12515	COG0180	Tryptophanyl-tRNA synthetase
GBCGDNIH2_RS12520	COG0463	Glycosyl transferase, family 2
GBCGDNIH2_RS12530	COG3585	molybdate ion transport
GBCGDNIH2_RS12535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GBCGDNIH2_RS12560	COG0181	hydroxymethylbilane synthase activity
GBCGDNIH2_RS12565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GBCGDNIH2_RS12570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GBCGDNIH2_RS12575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GBCGDNIH2_RS12580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GBCGDNIH2_RS12590	COG0306	phosphate transporter
GBCGDNIH2_RS12595	COG1981	membrane
GBCGDNIH2_RS12600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GBCGDNIH2_RS12610	COG0513	Belongs to the DEAD box helicase family
GBCGDNIH2_RS12645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GBCGDNIH2_RS12715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GBCGDNIH2_RS12720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex