locus-tag	class	description
YC6258_RS00035	COG3789	protein conserved in bacteria
YC6258_RS00040	COG1842	Phage shock protein A
YC6258_RS00055	COG3766	membrane
YC6258_RS00065	COG0754	glutathionylspermidine amidase activity
YC6258_RS00075	COG1446	asparaginase
YC6258_RS00080	COG0445	tRNA wobble uridine modification
YC6258_RS00085	COG0357	Ribosomal RNA small subunit methyltransferase G
YC6258_RS00090	COG1192	Involved in chromosome partitioning
YC6258_RS00095	COG1475	DNA binding
YC6258_RS00115	COG1063	alcohol dehydrogenase
YC6258_RS00120	COG2315	Protein conserved in bacteria
YC6258_RS00140	COG0577	efflux transmembrane transporter activity
YC6258_RS00140	COG1136	(ABC) transporter
YC6258_RS00230	COG2378	regulation of single-species biofilm formation
YC6258_RS00250	COG5297	Belongs to the glycosyl hydrolase family 6
YC6258_RS00255	COG2824	Alkylphosphonate utilization operon protein PhnA
YC6258_RS00265	COG3383	formate dehydrogenase (NAD+) activity
YC6258_RS00270	COG2966	Psort location CytoplasmicMembrane, score
YC6258_RS00285	COG3141	response to X-ray
YC6258_RS00290	COG3401	FG-GAP repeat protein
YC6258_RS00310	COG0402	S-adenosylhomocysteine deaminase activity
YC6258_RS00315	COG2351	hydroxyisourate hydrolase activity
YC6258_RS00330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YC6258_RS00370	COG3706	GGDEF domain
YC6258_RS00385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YC6258_RS00390	COG1561	YicC-like family, N-terminal region
YC6258_RS00395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
YC6258_RS00410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
YC6258_RS00450	COG1797	cobyrinic acid a,c-diamide synthase activity
YC6258_RS00460	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
YC6258_RS00540	COG0583	DNA-binding transcription factor activity
YC6258_RS00545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YC6258_RS00550	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS00560	COG0252	asparaginase activity
YC6258_RS00570	COG1115	amino acid carrier protein
YC6258_RS00585	COG0601	transmembrane transport
YC6258_RS00590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YC6258_RS00595	COG4172	Belongs to the ABC transporter superfamily
YC6258_RS00655	COG0194	GDP metabolic process
YC6258_RS00660	COG1758	RNA polymerase activity
YC6258_RS00665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YC6258_RS00670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YC6258_RS00675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YC6258_RS00675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YC6258_RS00680	COG0347	Belongs to the P(II) protein family
YC6258_RS00685	COG0004	ammonium transporteR
YC6258_RS00690	COG0347	Belongs to the P(II) protein family
YC6258_RS00730	COG0573	inorganic phosphate transmembrane transporter activity
YC6258_RS00740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YC6258_RS00755	COG0582	viral genome integration into host DNA
YC6258_RS00850	COG0107	imidazoleglycerol-phosphate synthase activity
YC6258_RS00855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YC6258_RS00860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YC6258_RS00875	COG3852	Histidine kinase
YC6258_RS00880	COG2204	response regulator
YC6258_RS00885	COG0456	acetyltransferase
YC6258_RS00895	COG1175	transmembrane transport
YC6258_RS00900	COG0395	ABC-type sugar transport system, permease component
YC6258_RS00905	COG2723	6-phospho-beta-galactosidase activity
YC6258_RS00910	COG2703	oxygen carrier activity
YC6258_RS00915	COG0545	Peptidyl-prolyl cis-trans isomerase
YC6258_RS00920	COG2198	Histidine kinase
YC6258_RS00920	COG5002	protein histidine kinase activity
YC6258_RS00920	COG0784	Response regulator, receiver
YC6258_RS00925	COG2239	Acts as a magnesium transporter
YC6258_RS00935	COG0606	chelatase, subunit chli
YC6258_RS00945	COG1959	2 iron, 2 sulfur cluster binding
YC6258_RS00970	COG3209	COG3209 Rhs family protein
YC6258_RS00975	COG1061	Type III restriction enzyme res subunit
YC6258_RS00990	COG0270	DNA (cytosine-5-)-methyltransferase activity
YC6258_RS01015	COG0758	DNA mediated transformation
YC6258_RS01050	COG3077	Addiction module antitoxin, RelB DinJ family
YC6258_RS01145	COG0606	chelatase, subunit chli
YC6258_RS01210	COG2814	Major facilitator Superfamily
YC6258_RS01225	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
YC6258_RS01235	COG1122	ATPase activity
YC6258_RS01240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
YC6258_RS01245	COG1268	BioY protein
YC6258_RS01265	COG0483	inositol monophosphate 1-phosphatase activity
YC6258_RS01270	COG0505	Belongs to the CarA family
YC6258_RS01275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YC6258_RS01285	COG2169	Transcriptional regulator
YC6258_RS01285	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS01305	COG1764	response to oxidative stress
YC6258_RS01310	COG1846	Transcriptional regulator
YC6258_RS01315	COG1733	regulation of RNA biosynthetic process
YC6258_RS01320	COG0765	amino acid transport
YC6258_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS01340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YC6258_RS01355	COG0667	Aldo Keto reductase
YC6258_RS01360	COG0667	Aldo Keto reductase
YC6258_RS01375	COG1472	Belongs to the glycosyl hydrolase 3 family
YC6258_RS01385	COG4214	carbohydrate transport
YC6258_RS01390	COG1129	ABC transporter
YC6258_RS01395	COG4213	ABC transporter substrate-binding protein
YC6258_RS01430	COG0471	metal ion transport
YC6258_RS01435	COG3852	Histidine kinase
YC6258_RS01450	COG1131	(ABC) transporter
YC6258_RS01465	COG0842	Transport permease protein
YC6258_RS01470	COG0842	Transport permease protein
YC6258_RS01475	COG1131	(ABC) transporter
YC6258_RS01480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YC6258_RS01490	COG0006	proline dipeptidase activity
YC6258_RS01495	COG1011	Hydrolase
YC6258_RS01565	COG1715	Restriction endonuclease
YC6258_RS01610	COG1247	-acetyltransferase
YC6258_RS01615	COG0583	DNA-binding transcription factor activity
YC6258_RS01625	COG0778	Nitroreductase
YC6258_RS01635	COG0672	)-iron permease
YC6258_RS01650	COG0489	protein tyrosine kinase activity
YC6258_RS01675	COG1091	dTDP-4-dehydrorhamnose reductase activity
YC6258_RS01695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YC6258_RS01705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YC6258_RS01720	COG3409	Peptidoglycan-binding domain 1 protein
YC6258_RS01720	COG3267	Type II secretory pathway component ExeA
YC6258_RS01725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YC6258_RS01740	COG0210	DNA helicase
YC6258_RS01745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YC6258_RS01760	COG0750	zinc metalloprotease
YC6258_RS01775	COG2204	response regulator
YC6258_RS01785	COG0537	adenosine 5'-monophosphoramidase activity
YC6258_RS01790	COG0740	serine-type endopeptidase activity
YC6258_RS01800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YC6258_RS01810	COG0583	DNA-binding transcription factor activity
YC6258_RS01835	COG0513	Belongs to the DEAD box helicase family
YC6258_RS01845	COG2267	carboxylic ester hydrolase activity
YC6258_RS01850	COG2885	chlorophyll binding
YC6258_RS01860	COG0438	transferase activity, transferring glycosyl groups
YC6258_RS01875	COG0534	Mate efflux family protein
YC6258_RS01885	COG1522	sequence-specific DNA binding
YC6258_RS01890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YC6258_RS01935	COG0583	DNA-binding transcription factor activity
YC6258_RS01950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YC6258_RS01960	COG1653	transport
YC6258_RS01965	COG1175	transmembrane transport
YC6258_RS01970	COG0395	ABC-type sugar transport system, permease component
YC6258_RS01975	COG0366	Alpha amylase catalytic
YC6258_RS01980	COG1609	Transcriptional regulator
YC6258_RS02000	COG0430	RNA-3'-phosphate cyclase activity
YC6258_RS02005	COG1690	Belongs to the RtcB family
YC6258_RS02020	COG4650	regulator
YC6258_RS02035	COG3541	Predicted nucleotidyltransferase
YC6258_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YC6258_RS02055	COG1136	(ABC) transporter
YC6258_RS02055	COG0577	efflux transmembrane transporter activity
YC6258_RS02060	COG0577	efflux transmembrane transporter activity
YC6258_RS02060	COG1136	(ABC) transporter
YC6258_RS02085	COG2207	Transcriptional regulator
YC6258_RS02085	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS02160	COG3842	ATPase activity
YC6258_RS02165	COG1176	ABC-type spermidine putrescine transport system, permease component I
YC6258_RS02170	COG1177	transmembrane transport
YC6258_RS02190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YC6258_RS02200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YC6258_RS02205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YC6258_RS02210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YC6258_RS02225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YC6258_RS02230	COG0363	glucosamine-6-phosphate deaminase activity
YC6258_RS02235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YC6258_RS02240	COG2188	Transcriptional regulator
YC6258_RS02245	COG2971	BadF BadG BcrA BcrD
YC6258_RS02335	COG2165	general secretion pathway protein
YC6258_RS02360	COG4232	protein-disulfide reductase activity
YC6258_RS02375	COG1983	PspC domain protein
YC6258_RS02385	COG1842	Phage shock protein A
YC6258_RS02390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YC6258_RS02400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS02405	COG1609	Transcriptional regulator
YC6258_RS02420	COG2130	NADP-dependent
YC6258_RS02430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YC6258_RS02475	COG3706	GGDEF domain
YC6258_RS02495	COG0024	Methionine aminopeptidase
YC6258_RS02500	COG1595	DNA-templated transcription, initiation
YC6258_RS02505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YC6258_RS02515	COG0745	RESPONSE REGULATOR receiver
YC6258_RS02520	COG2205	protein histidine kinase activity
YC6258_RS02525	COG0778	Nitroreductase
YC6258_RS02530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YC6258_RS02535	COG0706	membrane insertase activity
YC6258_RS02540	COG0594	ribonuclease P activity
YC6258_RS02545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YC6258_RS02565	COG1368	sulfuric ester hydrolase activity
YC6258_RS02585	COG0009	L-threonylcarbamoyladenylate synthase
YC6258_RS02590	COG0758	DNA mediated transformation
YC6258_RS02600	COG0242	peptide deformylase activity
YC6258_RS02615	COG0569	domain protein
YC6258_RS02620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YC6258_RS02630	COG0752	glycyl-tRNA synthetase alpha subunit
YC6258_RS02635	COG0751	glycine-tRNA ligase activity
YC6258_RS02640	COG0204	Acyl-transferase
YC6258_RS02680	COG1175	transmembrane transport
YC6258_RS02690	COG3842	ATPase activity
YC6258_RS02700	COG1609	Transcriptional regulator
YC6258_RS02710	COG0443	Heat shock 70 kDa protein
YC6258_RS02825	COG1191	sigma factor activity
YC6258_RS02830	COG1338	Plays a role in the flagellum-specific transport system
YC6258_RS02840	COG1776	CheC inhibitor of MCP methylation
YC6258_RS02840	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YC6258_RS02850	COG1749	Flagellar hook protein flgE
YC6258_RS02855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YC6258_RS02870	COG1157	protein secretion by the type III secretion system
YC6258_RS02885	COG1766	The M ring may be actively involved in energy transduction
YC6258_RS02890	COG1677	Flagellar hook-basal body complex protein FliE
YC6258_RS02895	COG1558	bacterial-type flagellum-dependent cell motility
YC6258_RS02905	COG1706	bacterial-type flagellum-dependent cell motility
YC6258_RS02910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YC6258_RS02920	COG4786	Flagellar basal body rod
YC6258_RS02925	COG4786	Flagellar basal body rod
YC6258_RS02930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YC6258_RS02935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YC6258_RS02970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS02985	COG1176	ABC-type spermidine putrescine transport system, permease component I
YC6258_RS02995	COG3842	ATPase activity
YC6258_RS03000	COG2186	Transcriptional regulator
YC6258_RS03010	COG0277	FAD linked oxidase domain protein
YC6258_RS03025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YC6258_RS03025	COG1024	Enoyl-CoA hydratase
YC6258_RS03045	COG2828	Protein conserved in bacteria
YC6258_RS03050	COG0583	DNA-binding transcription factor activity
YC6258_RS03075	COG0473	3-isopropylmalate dehydrogenase activity
YC6258_RS03080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YC6258_RS03085	COG0339	signal peptide processing
YC6258_RS03105	COG0438	transferase activity, transferring glycosyl groups
YC6258_RS03120	COG0564	pseudouridine synthase activity
YC6258_RS03150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YC6258_RS03155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YC6258_RS03185	COG1612	heme a metabolic process
YC6258_RS03200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
YC6258_RS03220	COG0426	domain, Protein
YC6258_RS03220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YC6258_RS03235	COG0356	it plays a direct role in the translocation of protons across the membrane
YC6258_RS03245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YC6258_RS03255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YC6258_RS03260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YC6258_RS03265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YC6258_RS03270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YC6258_RS03280	COG2204	response regulator
YC6258_RS03315	COG1442	glycosyl transferase family 8
YC6258_RS03315	COG1216	Glycosyl transferase, family 2
YC6258_RS03380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YC6258_RS03380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YC6258_RS03385	COG3507	Belongs to the glycosyl hydrolase 43 family
YC6258_RS03390	COG2373	Large extracellular alpha-helical protein
YC6258_RS03395	COG1653	transport
YC6258_RS03410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YC6258_RS03415	COG3227	Zinc metalloprotease (Elastase)
YC6258_RS03430	COG4953	penicillin-binding protein 1C
YC6258_RS03590	COG0667	Aldo Keto reductase
YC6258_RS03595	COG0583	DNA-binding transcription factor activity
YC6258_RS03620	COG2203	Gaf domain
YC6258_RS03620	COG5001	Diguanylate cyclase
YC6258_RS03620	COG4251	negative regulation of phosphorylation
YC6258_RS03620	COG3706	GGDEF domain
YC6258_RS03625	COG2195	Cleaves the N-terminal amino acid of tripeptides
YC6258_RS03630	COG1671	Belongs to the UPF0178 family
YC6258_RS03655	COG4628	conserved protein (DUF2132)
YC6258_RS03720	COG2205	protein histidine kinase activity
YC6258_RS03740	COG1744	ABC transporter substrate-binding protein PnrA-like
YC6258_RS03750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YC6258_RS03755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YC6258_RS03765	COG2813	Specifically methylates the guanine in position
YC6258_RS03765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YC6258_RS03770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YC6258_RS03775	COG1872	DUF167
YC6258_RS03790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YC6258_RS03810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
YC6258_RS03830	COG1611	Belongs to the LOG family
YC6258_RS03845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YC6258_RS03860	COG1126	abc transporter atp-binding protein
YC6258_RS03865	COG0765	amino acid transport
YC6258_RS03870	COG4597	amino acid ABC transporter
YC6258_RS03875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS03890	COG0784	Response regulator, receiver
YC6258_RS03890	COG2205	protein histidine kinase activity
YC6258_RS03890	COG2198	Histidine kinase
YC6258_RS03915	COG1166	arginine decarboxylase activity
YC6258_RS03930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YC6258_RS03935	COG1773	rubredoxin
YC6258_RS03940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
YC6258_RS03955	COG0745	RESPONSE REGULATOR receiver
YC6258_RS03960	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YC6258_RS03980	COG1242	4 iron, 4 sulfur cluster binding
YC6258_RS04015	COG3608	succinylglutamate desuccinylase aspartoacylase
YC6258_RS04020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YC6258_RS04030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS04050	COG0531	amino acid
YC6258_RS04055	COG1522	sequence-specific DNA binding
YC6258_RS04115	COG0393	Putative heavy-metal-binding
YC6258_RS04120	COG0393	Putative heavy-metal-binding
YC6258_RS04130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YC6258_RS04155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YC6258_RS04160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YC6258_RS04165	COG2837	iron assimilation
YC6258_RS04170	COG0842	Transport permease protein
YC6258_RS04175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YC6258_RS04210	COG1696	Membrane protein involved in D-alanine export
YC6258_RS04250	COG0657	acetylesterase activity
YC6258_RS04255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YC6258_RS04260	COG0523	cobalamin synthesis protein
YC6258_RS04265	COG5001	Diguanylate cyclase
YC6258_RS04280	COG2154	pterin-4-alpha-carbinolamine dehydratase
YC6258_RS04300	COG0189	ligase activity
YC6258_RS04300	COG4067	protein conserved in archaea
YC6258_RS04315	COG2974	May be involved in recombination
YC6258_RS04330	COG2304	oxidoreductase activity
YC6258_RS04335	COG2205	protein histidine kinase activity
YC6258_RS04345	COG3072	Adenylate cyclase
YC6258_RS04355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YC6258_RS04360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
YC6258_RS04365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
YC6258_RS04370	COG0813	purine-nucleoside phosphorylase activity
YC6258_RS04395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YC6258_RS04410	COG0477	Major facilitator Superfamily
YC6258_RS04430	COG0583	DNA-binding transcription factor activity
YC6258_RS04450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
YC6258_RS04475	COG0302	gtp cyclohydrolase
YC6258_RS04480	COG0516	GMP reductase activity
YC6258_RS04480	COG0517	IMP dehydrogenase activity
YC6258_RS04485	COG0560	Phosphoserine phosphatase
YC6258_RS04495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YC6258_RS04500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YC6258_RS04505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YC6258_RS04510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
YC6258_RS04515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
YC6258_RS04525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YC6258_RS04530	COG0254	rRNA binding
YC6258_RS04535	COG0039	L-malate dehydrogenase activity
YC6258_RS04550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YC6258_RS04560	COG3118	belongs to the thioredoxin family
YC6258_RS04595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YC6258_RS04600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
YC6258_RS04610	COG0067	glutamate synthase
YC6258_RS04610	COG0069	glutamate synthase activity
YC6258_RS04610	COG0070	glutamate synthase
YC6258_RS04615	COG0493	'glutamate synthase
YC6258_RS04630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
YC6258_RS04645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YC6258_RS04650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YC6258_RS04660	COG0140	phosphoribosyl-ATP diphosphatase activity
YC6258_RS04665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YC6258_RS04685	COG1175	transmembrane transport
YC6258_RS04690	COG0395	ABC-type sugar transport system, permease component
YC6258_RS04695	COG3842	ATPase activity
YC6258_RS04700	COG3300	MHYT domain
YC6258_RS04700	COG5001	Diguanylate cyclase
YC6258_RS04710	COG2313	pseudouridylate synthase activity
YC6258_RS04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YC6258_RS04715	COG1522	sequence-specific DNA binding
YC6258_RS04725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YC6258_RS04735	COG1309	transcriptional regulator
YC6258_RS04740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YC6258_RS04750	COG0756	dUTP diphosphatase activity
YC6258_RS04755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YC6258_RS04760	COG1940	carbohydrate kinase activity
YC6258_RS04760	COG1846	Transcriptional regulator
YC6258_RS04765	COG2003	Belongs to the UPF0758 family
YC6258_RS04770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YC6258_RS04775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YC6258_RS04780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YC6258_RS04790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YC6258_RS04800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YC6258_RS04825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YC6258_RS04830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YC6258_RS04830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YC6258_RS04840	COG0673	inositol 2-dehydrogenase activity
YC6258_RS04860	COG3842	ATPase activity
YC6258_RS04865	COG3833	ABC-type maltose transport systems, permease component
YC6258_RS04870	COG1175	transmembrane transport
YC6258_RS04875	COG1653	transport
YC6258_RS04880	COG1609	Transcriptional regulator
YC6258_RS04885	COG0778	Nitroreductase
YC6258_RS04905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS04910	COG1819	glycosyl
YC6258_RS04965	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS05065	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS05070	COG0823	Involved in the tonB-independent uptake of proteins
YC6258_RS05075	COG1175	transmembrane transport
YC6258_RS05080	COG0395	ABC-type sugar transport system, permease component
YC6258_RS05085	COG3842	ATPase activity
YC6258_RS05090	COG1653	transport
YC6258_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS05105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YC6258_RS05110	COG0800	Aldolase
YC6258_RS05115	COG1414	Transcriptional regulator
YC6258_RS05120	COG1609	Transcriptional regulator
YC6258_RS05130	COG0673	inositol 2-dehydrogenase activity
YC6258_RS05135	COG1501	Belongs to the glycosyl hydrolase 31 family
YC6258_RS05215	COG1222	aaa ATPase
YC6258_RS05235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS05240	COG0659	secondary active sulfate transmembrane transporter activity
YC6258_RS05245	COG0840	transmembrane signaling receptor activity
YC6258_RS05250	COG0494	nUDIX hydrolase
YC6258_RS05275	COG0346	lactoylglutathione lyase activity
YC6258_RS05305	COG0739	heme binding
YC6258_RS05315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YC6258_RS05340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YC6258_RS05345	COG2977	Belongs to the P-Pant transferase superfamily
YC6258_RS05355	COG0826	peptidase U32
YC6258_RS05360	COG0826	peptidase U32
YC6258_RS05365	COG3154	lipid carrier protein
YC6258_RS05390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YC6258_RS05400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YC6258_RS05405	COG0673	inositol 2-dehydrogenase activity
YC6258_RS05425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YC6258_RS05430	COG1609	Transcriptional regulator
YC6258_RS05435	COG1609	Transcriptional regulator
YC6258_RS05490	COG1309	transcriptional regulator
YC6258_RS05510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YC6258_RS05515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
YC6258_RS05540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YC6258_RS05555	COG0673	inositol 2-dehydrogenase activity
YC6258_RS05570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YC6258_RS05580	COG0488	(ABC) transporter
YC6258_RS05895	COG0840	transmembrane signaling receptor activity
YC6258_RS05910	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS05910	COG2169	Transcriptional regulator
YC6258_RS05915	COG2226	methyltransferase
YC6258_RS05935	COG2814	Major facilitator Superfamily
YC6258_RS05950	COG5001	Diguanylate cyclase
YC6258_RS05950	COG4251	negative regulation of phosphorylation
YC6258_RS05950	COG3706	GGDEF domain
YC6258_RS05950	COG2203	Gaf domain
YC6258_RS05960	COG0513	Belongs to the DEAD box helicase family
YC6258_RS05970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YC6258_RS05980	COG1309	transcriptional regulator
YC6258_RS05985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YC6258_RS05990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YC6258_RS05995	COG0840	transmembrane signaling receptor activity
YC6258_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS06005	COG5413	integral membrane protein
YC6258_RS06015	COG0154	amidase activity
YC6258_RS06025	COG0730	response to heat
YC6258_RS06030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YC6258_RS06045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YC6258_RS06055	COG4977	sequence-specific DNA binding
YC6258_RS06055	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS06085	COG1271	oxidase subunit
YC6258_RS06090	COG1294	oxidase, subunit
YC6258_RS06095	COG0791	NLP P60 protein
YC6258_RS06105	COG2814	Major facilitator Superfamily
YC6258_RS06110	COG0583	DNA-binding transcription factor activity
YC6258_RS06115	COG1301	dicarboxylic acid transport
YC6258_RS06120	COG3706	GGDEF domain
YC6258_RS06120	COG4251	negative regulation of phosphorylation
YC6258_RS06120	COG5001	Diguanylate cyclase
YC6258_RS06120	COG2203	Gaf domain
YC6258_RS06130	COG2319	Wd-40 repeat
YC6258_RS06130	COG4249	Peptidase C14 caspase catalytic subunit p20
YC6258_RS06140	COG0443	Heat shock 70 kDa protein
YC6258_RS06155	COG0583	DNA-binding transcription factor activity
YC6258_RS06160	COG1404	Belongs to the peptidase S8 family
YC6258_RS06175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YC6258_RS06190	COG0189	ligase activity
YC6258_RS06210	COG0840	transmembrane signaling receptor activity
YC6258_RS06215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YC6258_RS06220	COG0784	Response regulator, receiver
YC6258_RS06220	COG2198	Histidine kinase
YC6258_RS06220	COG0643	Histidine kinase
YC6258_RS06240	COG0708	Exodeoxyribonuclease III
YC6258_RS06245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
YC6258_RS06250	COG2814	Major facilitator Superfamily
YC6258_RS06260	COG0500	methyltransferase
YC6258_RS06275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
YC6258_RS06280	COG0247	lactate metabolic process
YC6258_RS06280	COG2181	nitrate reductase activity
YC6258_RS06285	COG1902	pentaerythritol trinitrate reductase activity
YC6258_RS06285	COG0446	pyridine nucleotide-disulphide oxidoreductase
YC6258_RS06310	COG0584	glycerophosphoryl diester phosphodiesterase
YC6258_RS06330	COG3220	belongs to the UPF0276 family
YC6258_RS06365	COG2204	response regulator
YC6258_RS06375	COG2205	protein histidine kinase activity
YC6258_RS06385	COG1960	acyl-CoA dehydrogenase activity
YC6258_RS06390	COG1960	acyl-CoA dehydrogenase activity
YC6258_RS06395	COG1960	acyl-CoA dehydrogenase activity
YC6258_RS06415	COG4608	Belongs to the ABC transporter superfamily
YC6258_RS06420	COG0444	Belongs to the ABC transporter superfamily
YC6258_RS06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YC6258_RS06430	COG0601	transmembrane transport
YC6258_RS06435	COG0747	negative chemotaxis
YC6258_RS06455	COG4215	(ABC) transporter
YC6258_RS06460	COG4160	amino acid transport
YC6258_RS06475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YC6258_RS06495	COG0006	proline dipeptidase activity
YC6258_RS06500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YC6258_RS06510	COG2959	enzyme of heme biosynthesis
YC6258_RS06560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YC6258_RS06565	COG2363	Small membrane protein
YC6258_RS06575	COG2177	Part of the ABC transporter FtsEX involved in
YC6258_RS06580	COG2884	Cell division ATP-binding protein ftsE
YC6258_RS06585	COG0552	protein localization to endoplasmic reticulum
YC6258_RS06595	COG0742	ribosomal rna small subunit methyltransferase
YC6258_RS06605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YC6258_RS06610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YC6258_RS06620	COG3275	phosphorelay sensor kinase activity
YC6258_RS06625	COG0840	transmembrane signaling receptor activity
YC6258_RS06630	COG0165	Argininosuccinate lyase
YC6258_RS06650	COG5001	Diguanylate cyclase
YC6258_RS06650	COG3300	MHYT domain
YC6258_RS06660	COG0071	Belongs to the small heat shock protein (HSP20) family
YC6258_RS06665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YC6258_RS06685	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YC6258_RS06685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YC6258_RS06695	COG0243	molybdopterin cofactor binding
YC6258_RS06700	COG3043	anaerobic respiration
YC6258_RS06705	COG3005	denitrification pathway
YC6258_RS06710	COG0314	molybdopterin synthase activity
YC6258_RS06715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YC6258_RS06720	COG0315	cyclic pyranopterin monophosphate synthase activity
YC6258_RS06725	COG0521	Mo-molybdopterin cofactor biosynthetic process
YC6258_RS06730	COG0746	molybdenum cofactor guanylyltransferase activity
YC6258_RS06735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YC6258_RS06750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YC6258_RS06750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YC6258_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS06760	COG0284	orotidine-5'-phosphate decarboxylase activity
YC6258_RS06770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YC6258_RS06775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
YC6258_RS06790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YC6258_RS06805	COG0601	transmembrane transport
YC6258_RS06810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YC6258_RS06825	COG0129	dihydroxy-acid dehydratase activity
YC6258_RS06830	COG1194	a g-specific adenine glycosylase
YC6258_RS06835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
YC6258_RS06855	COG1739	Uncharacterized protein family UPF0029
YC6258_RS06865	COG0748	coenzyme F420 binding
YC6258_RS06915	COG1472	Belongs to the glycosyl hydrolase 3 family
YC6258_RS06920	COG1566	PFAM secretion protein HlyD family protein
YC6258_RS06935	COG3706	GGDEF domain
YC6258_RS06945	COG1289	transmembrane transporter activity
YC6258_RS06960	COG1575	Belongs to the MenA family. Type 1 subfamily
YC6258_RS06965	COG0561	phosphatase activity
YC6258_RS06990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YC6258_RS07005	COG0436	Aminotransferase
YC6258_RS07010	COG1489	DNA binding
YC6258_RS07015	COG0697	spore germination
YC6258_RS07030	COG0784	Response regulator, receiver
YC6258_RS07030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS07030	COG2198	Histidine kinase
YC6258_RS07030	COG2205	protein histidine kinase activity
YC6258_RS07035	COG0406	alpha-ribazole phosphatase activity
YC6258_RS07065	COG0840	transmembrane signaling receptor activity
YC6258_RS07085	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
YC6258_RS07090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YC6258_RS07115	COG0765	amino acid transport
YC6258_RS07120	COG0765	amino acid transport
YC6258_RS07155	COG0583	DNA-binding transcription factor activity
YC6258_RS07165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YC6258_RS07180	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
YC6258_RS07185	COG1178	ABC-type Fe3 transport system permease component
YC6258_RS07200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YC6258_RS07200	COG0493	'glutamate synthase
YC6258_RS07205	COG0840	transmembrane signaling receptor activity
YC6258_RS07275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YC6258_RS07300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YC6258_RS07305	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS07310	COG1309	transcriptional regulator
YC6258_RS07320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YC6258_RS07330	COG0840	transmembrane signaling receptor activity
YC6258_RS07335	COG3185	4-Hydroxyphenylpyruvate dioxygenase
YC6258_RS07335	COG1082	Xylose isomerase domain protein TIM barrel
YC6258_RS07350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS07360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YC6258_RS07370	COG2356	endonuclease I
YC6258_RS07380	COG1404	Belongs to the peptidase S8 family
YC6258_RS07390	COG0450	alkyl hydroperoxide reductase
YC6258_RS07440	COG0673	inositol 2-dehydrogenase activity
YC6258_RS07450	COG4251	negative regulation of phosphorylation
YC6258_RS07450	COG3706	GGDEF domain
YC6258_RS07450	COG2203	Gaf domain
YC6258_RS07450	COG5001	Diguanylate cyclase
YC6258_RS07540	COG0454	-acetyltransferase
YC6258_RS07555	COG0366	Alpha amylase catalytic
YC6258_RS07565	COG1609	Transcriptional regulator
YC6258_RS07580	COG0848	biopolymer transport protein
YC6258_RS07585	COG0811	peptide transport
YC6258_RS07600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS07605	COG0251	oxidation-reduction process
YC6258_RS07610	COG2423	ornithine cyclodeaminase activity
YC6258_RS07660	COG1396	sequence-specific DNA binding
YC6258_RS07665	COG3135	benzoate transporter
YC6258_RS07670	COG0583	DNA-binding transcription factor activity
YC6258_RS07680	COG3459	Glycosyltransferase 36 associated
YC6258_RS07695	COG3001	Fructosamine kinase
YC6258_RS07770	COG1760	l-serine dehydratase
YC6258_RS07800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YC6258_RS07800	COG0446	pyridine nucleotide-disulphide oxidoreductase
YC6258_RS07830	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
YC6258_RS07830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS07850	COG1960	acyl-CoA dehydrogenase activity
YC6258_RS07860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YC6258_RS07865	COG0659	secondary active sulfate transmembrane transporter activity
YC6258_RS07870	COG0589	response to stress
YC6258_RS07880	COG0572	uridine kinase
YC6258_RS07885	COG0126	phosphoglycerate kinase activity
YC6258_RS07910	COG3842	ATPase activity
YC6258_RS07920	COG1176	ABC-type spermidine putrescine transport system, permease component I
YC6258_RS07935	COG0583	DNA-binding transcription factor activity
YC6258_RS07940	COG3706	GGDEF domain
YC6258_RS07940	COG2203	Gaf domain
YC6258_RS07940	COG5001	Diguanylate cyclase
YC6258_RS07940	COG4251	negative regulation of phosphorylation
YC6258_RS07945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YC6258_RS07975	COG1175	transmembrane transport
YC6258_RS07980	COG3833	ABC-type maltose transport systems, permease component
YC6258_RS07985	COG0071	Belongs to the small heat shock protein (HSP20) family
YC6258_RS07990	COG0179	Fumarylacetoacetate (FAA) hydrolase
YC6258_RS07995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
YC6258_RS08005	COG0417	DNA replication proofreading
YC6258_RS08010	COG0583	DNA-binding transcription factor activity
YC6258_RS08030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YC6258_RS08035	COG0667	Aldo Keto reductase
YC6258_RS08050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YC6258_RS08050	COG0517	IMP dehydrogenase activity
YC6258_RS08065	COG2721	sulfolactate sulfo-lyase activity
YC6258_RS08100	COG1609	Transcriptional regulator
YC6258_RS08115	COG2084	Dehydrogenase
YC6258_RS08120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YC6258_RS08125	COG4136	ATPase activity
YC6258_RS08130	COG4135	transport system, permease component
YC6258_RS08135	COG4134	Bacterial extracellular solute-binding protein
YC6258_RS08155	COG0859	PFAM glycosyl transferase family 9
YC6258_RS08165	COG1560	Kdo2-lipid A biosynthetic process
YC6258_RS08175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YC6258_RS08185	COG1519	Transferase
YC6258_RS08190	COG1538	Outer membrane efflux protein
YC6258_RS08195	COG0494	nUDIX hydrolase
YC6258_RS08205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YC6258_RS08210	COG3150	esterase
YC6258_RS08225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YC6258_RS08275	COG2391	methyltransferase activity
YC6258_RS08285	COG3639	organic phosphonate transmembrane transporter activity
YC6258_RS08290	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
YC6258_RS08295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YC6258_RS08300	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YC6258_RS08320	COG2391	methyltransferase activity
YC6258_RS08365	COG0546	phosphoglycolate phosphatase activity
YC6258_RS08385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YC6258_RS08400	COG3033	Beta-eliminating lyase
YC6258_RS08410	COG1132	(ABC) transporter
YC6258_RS08415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YC6258_RS08450	COG2116	formate transmembrane transporter activity
YC6258_RS08460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YC6258_RS08460	COG2146	nitrite reductase [NAD(P)H] activity
YC6258_RS08465	COG3707	response regulator
YC6258_RS08470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
YC6258_RS08480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YC6258_RS08490	COG0723	plastoquinol--plastocyanin reductase activity
YC6258_RS08495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YC6258_RS08500	COG2857	Cytochrome c1
YC6258_RS08505	COG0625	glutathione transferase activity
YC6258_RS08535	COG1940	carbohydrate kinase activity
YC6258_RS08545	COG1175	transmembrane transport
YC6258_RS08550	COG0395	ABC-type sugar transport system, permease component
YC6258_RS08560	COG0587	DNA-directed DNA polymerase activity
YC6258_RS08580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YC6258_RS08585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YC6258_RS08600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YC6258_RS08610	COG1070	Carbohydrate kinase
YC6258_RS08635	COG1215	transferase activity, transferring glycosyl groups
YC6258_RS08650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YC6258_RS08650	COG0301	tRNA thio-modification
YC6258_RS08655	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
YC6258_RS08665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YC6258_RS08670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YC6258_RS08675	COG4942	peptidase
YC6258_RS08680	COG0793	Belongs to the peptidase S41A family
YC6258_RS08685	COG2861	carbohydrate metabolic process
YC6258_RS08690	COG0084	hydrolase, TatD family'
YC6258_RS08700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YC6258_RS08725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YC6258_RS08735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YC6258_RS08750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS08760	COG3830	Belongs to the UPF0237 family
YC6258_RS08760	COG0560	Phosphoserine phosphatase
YC6258_RS08825	COG0840	transmembrane signaling receptor activity
YC6258_RS08835	COG3005	denitrification pathway
YC6258_RS08845	COG2914	Belongs to the UPF0125 (RnfH) family
YC6258_RS08865	COG4656	Part of a membrane complex involved in electron transport
YC6258_RS08875	COG4657	Part of a membrane complex involved in electron transport
YC6258_RS09000	COG1690	Belongs to the RtcB family
YC6258_RS09010	COG2132	Multicopper oxidase
YC6258_RS09015	COG1966	Carbon starvation protein
YC6258_RS09040	COG1309	transcriptional regulator
YC6258_RS09055	COG1501	Belongs to the glycosyl hydrolase 31 family
YC6258_RS09060	COG3279	Response regulator of the LytR AlgR family
YC6258_RS09065	COG3275	phosphorelay sensor kinase activity
YC6258_RS09190	COG3284	Transcriptional regulator
YC6258_RS09195	COG3842	ATPase activity
YC6258_RS09200	COG3842	ATPase activity
YC6258_RS09210	COG0395	ABC-type sugar transport system, permease component
YC6258_RS09240	COG4615	Cyclic peptide transporter
YC6258_RS09285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YC6258_RS09310	COG1309	transcriptional regulator
YC6258_RS09315	COG1538	Outer membrane efflux protein
YC6258_RS09320	COG1566	PFAM secretion protein HlyD family protein
YC6258_RS09325	COG2814	Major facilitator Superfamily
YC6258_RS09365	COG1051	belongs to the nudix hydrolase family
YC6258_RS09365	COG1056	cytidyltransferase-related domain
YC6258_RS09485	COG0859	PFAM glycosyl transferase family 9
YC6258_RS09485	COG0457	Tetratricopeptide repeat
YC6258_RS09505	COG3661	Belongs to the glycosyl hydrolase 67 family
YC6258_RS09525	COG1280	lysine exporter protein (LysE YggA)
YC6258_RS09530	COG0702	epimerase
YC6258_RS09545	COG1309	transcriptional regulator
YC6258_RS09550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
YC6258_RS09570	COG2119	membrane
YC6258_RS09575	COG0583	DNA-binding transcription factor activity
YC6258_RS09585	COG0625	glutathione transferase activity
YC6258_RS09595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YC6258_RS09600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YC6258_RS09605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YC6258_RS09610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YC6258_RS09615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YC6258_RS09620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YC6258_RS09800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YC6258_RS09825	COG1309	transcriptional regulator
YC6258_RS09845	COG4176	ABC-type proline glycine betaine transport system permease component
YC6258_RS09850	COG4175	Glycine betaine
YC6258_RS09850	COG3448	diguanylate cyclase activity
YC6258_RS09880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YC6258_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS09890	COG0617	tRNA 3'-terminal CCA addition
YC6258_RS09905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YC6258_RS09910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YC6258_RS09910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YC6258_RS09925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YC6258_RS09930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YC6258_RS09985	COG0525	valine-tRNA ligase activity
YC6258_RS09990	COG3647	Membrane
YC6258_RS10010	COG0384	phenazine biosynthesis protein PhzF
YC6258_RS10020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YC6258_RS10025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YC6258_RS10030	COG0604	alcohol dehydrogenase
YC6258_RS10035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YC6258_RS10045	COG1120	ATPase activity
YC6258_RS10055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS10060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS10070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YC6258_RS10075	COG4172	Belongs to the ABC transporter superfamily
YC6258_RS10080	COG4171	peptide transport system, permease
YC6258_RS10085	COG0601	transmembrane transport
YC6258_RS10090	COG0747	negative chemotaxis
YC6258_RS10105	COG2723	6-phospho-beta-galactosidase activity
YC6258_RS10110	COG2814	Major facilitator Superfamily
YC6258_RS10175	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
YC6258_RS10180	COG3604	Transcriptional regulator
YC6258_RS10185	COG0840	transmembrane signaling receptor activity
YC6258_RS10190	COG0840	transmembrane signaling receptor activity
YC6258_RS10195	COG2249	NAD(P)H dehydrogenase (quinone) activity
YC6258_RS10200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YC6258_RS10205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YC6258_RS10215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YC6258_RS10220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YC6258_RS10230	COG0745	RESPONSE REGULATOR receiver
YC6258_RS10235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YC6258_RS10240	COG0305	Participates in initiation and elongation during chromosome replication
YC6258_RS10245	COG0359	binds to the 23S rRNA
YC6258_RS10255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YC6258_RS10260	COG0360	Binds together with S18 to 16S ribosomal RNA
YC6258_RS10265	COG0501	Belongs to the peptidase M48B family
YC6258_RS10270	COG1704	LemA family
YC6258_RS10275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YC6258_RS10280	COG0557	exoribonuclease II activity
YC6258_RS10285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YC6258_RS10290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YC6258_RS10295	COG0330	HflC and HflK could
YC6258_RS10300	COG0330	HflC and HflK could
YC6258_RS10305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YC6258_RS10310	COG1923	regulation of RNA biosynthetic process
YC6258_RS10315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YC6258_RS10320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YC6258_RS10325	COG0860	N-Acetylmuramoyl-L-alanine amidase
YC6258_RS10330	COG0802	atpase or kinase
YC6258_RS10350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YC6258_RS10355	COG0688	phosphatidylethanolamine metabolic process
YC6258_RS10365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
YC6258_RS10370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YC6258_RS10390	COG0248	Ppx GppA phosphatase
YC6258_RS10405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
YC6258_RS10410	COG5002	protein histidine kinase activity
YC6258_RS10410	COG2205	protein histidine kinase activity
YC6258_RS10410	COG0784	Response regulator, receiver
YC6258_RS10420	COG0138	bifunctional purine biosynthesis protein purh
YC6258_RS10430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YC6258_RS10440	COG2264	protein methyltransferase activity
YC6258_RS10455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YC6258_RS10475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YC6258_RS10500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YC6258_RS10505	COG0792	nuclease activity
YC6258_RS10510	COG3107	peptidoglycan biosynthetic process
YC6258_RS10520	COG2001	Belongs to the MraZ family
YC6258_RS10525	COG0275	rRNA processing
YC6258_RS10545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YC6258_RS10550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YC6258_RS10555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
YC6258_RS10560	COG0772	Belongs to the SEDS family
YC6258_RS10565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YC6258_RS10570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YC6258_RS10575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YC6258_RS10585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YC6258_RS10595	COG0739	heme binding
YC6258_RS10600	COG0653	protein targeting
YC6258_RS10605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
YC6258_RS10615	COG0237	dephospho-CoA kinase activity
YC6258_RS10640	COG3307	-O-antigen
YC6258_RS10665	COG0492	ferredoxin-NADP+ reductase activity
YC6258_RS10685	COG2224	Isocitrate lyase
YC6258_RS10700	COG0586	Pfam SNARE associated Golgi protein
YC6258_RS10705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YC6258_RS10710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YC6258_RS10720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YC6258_RS10725	COG0768	penicillin binding
YC6258_RS10730	COG0772	Belongs to the SEDS family
YC6258_RS10735	COG2951	lytic endotransglycosylase activity
YC6258_RS10750	COG0297	glycogen (starch) synthase activity
YC6258_RS10755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YC6258_RS10765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YC6258_RS10770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YC6258_RS10775	COG0676	glucose-6-phosphate 1-epimerase activity
YC6258_RS10780	COG0228	four-way junction DNA binding
YC6258_RS10785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YC6258_RS10790	COG0336	Belongs to the RNA methyltransferase TrmD family
YC6258_RS10795	COG0335	large ribosomal subunit rRNA binding
YC6258_RS10800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YC6258_RS10820	COG4206	TonB-dependent receptor
YC6258_RS10825	COG1278	Cold shock
YC6258_RS10830	COG0105	UTP biosynthetic process
YC6258_RS10835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
YC6258_RS10850	COG0124	histidyl-tRNA synthetase
YC6258_RS10865	COG1160	GTP binding
YC6258_RS10880	COG1570	exodeoxyribonuclease VII activity
YC6258_RS10890	COG0519	Catalyzes the synthesis of GMP from XMP
YC6258_RS10890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YC6258_RS10895	COG0583	DNA-binding transcription factor activity
YC6258_RS10900	COG0625	glutathione transferase activity
YC6258_RS10965	COG0583	DNA-binding transcription factor activity
YC6258_RS10970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YC6258_RS10975	COG1686	Belongs to the peptidase S11 family
YC6258_RS10980	COG2921	Belongs to the UPF0250 family
YC6258_RS10985	COG0321	lipoyl(octanoyl) transferase activity
YC6258_RS10990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YC6258_RS11000	COG3098	single-species biofilm formation
YC6258_RS11020	COG0596	Alpha beta hydrolase
YC6258_RS11035	COG0354	folic acid binding
YC6258_RS11040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
YC6258_RS11065	COG3026	antisigma factor binding
YC6258_RS11075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YC6258_RS11080	COG0481	GTPase activity
YC6258_RS11095	COG0571	ribonuclease III activity
YC6258_RS11100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YC6258_RS11105	COG1381	Involved in DNA repair and RecF pathway recombination
YC6258_RS11110	COG5002	protein histidine kinase activity
YC6258_RS11110	COG2205	protein histidine kinase activity
YC6258_RS11110	COG0784	Response regulator, receiver
YC6258_RS11120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YC6258_RS11125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YC6258_RS11130	COG3956	TIGRFAM MazG family protein
YC6258_RS11135	COG4535	Mg2 and Co2 transporter CorC
YC6258_RS11140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YC6258_RS11145	COG1702	phosphate starvation-inducible protein PhoH
YC6258_RS11150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YC6258_RS11190	COG0442	prolyl-tRNA aminoacylation
YC6258_RS11200	COG1388	LysM domain
YC6258_RS11200	COG4942	peptidase
YC6258_RS11215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YC6258_RS11220	COG1546	Belongs to the CinA family
YC6258_RS11230	COG2137	regulation of response to DNA damage stimulus
YC6258_RS11235	COG3507	Belongs to the glycosyl hydrolase 43 family
YC6258_RS11240	COG0395	ABC-type sugar transport system, permease component
YC6258_RS11245	COG1175	transmembrane transport
YC6258_RS11260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YC6258_RS11270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YC6258_RS11290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YC6258_RS11305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
YC6258_RS11365	COG0123	including yeast histone deacetylase and acetoin utilization protein
YC6258_RS11370	COG1042	CoA-binding domain protein
YC6258_RS11370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YC6258_RS11370	COG0045	succinate-CoA ligase (ADP-forming) activity
YC6258_RS11375	COG2816	NAD+ diphosphatase activity
YC6258_RS11390	COG0037	tRNA processing
YC6258_RS11415	COG2217	Heavy metal translocating P-type atpase
YC6258_RS11430	COG2010	Cytochrome c
YC6258_RS11445	COG3278	Belongs to the heme-copper respiratory oxidase family
YC6258_RS11460	COG0776	regulation of translation
YC6258_RS11465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YC6258_RS11475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YC6258_RS11480	COG0632	four-way junction helicase activity
YC6258_RS11485	COG2255	four-way junction helicase activity
YC6258_RS11490	COG0824	Thioesterase
YC6258_RS11510	COG0823	Involved in the tonB-independent uptake of proteins
YC6258_RS11515	COG2885	chlorophyll binding
YC6258_RS11520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YC6258_RS11525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YC6258_RS11540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
YC6258_RS11550	COG0425	Belongs to the sulfur carrier protein TusA family
YC6258_RS11560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YC6258_RS11565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YC6258_RS11575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YC6258_RS11575	COG0321	lipoyl(octanoyl) transferase activity
YC6258_RS11580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YC6258_RS11595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YC6258_RS11595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YC6258_RS11605	COG2409	Drug exporters of the RND superfamily
YC6258_RS11610	COG0189	ligase activity
YC6258_RS11630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YC6258_RS11680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YC6258_RS11685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS11695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
YC6258_RS11700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
YC6258_RS11715	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YC6258_RS11720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YC6258_RS11725	COG2171	N-acyltransferase activity
YC6258_RS11730	COG1393	Belongs to the ArsC family
YC6258_RS11735	COG0436	Aminotransferase
YC6258_RS11740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YC6258_RS11745	COG0024	Methionine aminopeptidase
YC6258_RS11750	COG0052	Belongs to the universal ribosomal protein uS2 family
YC6258_RS11755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YC6258_RS11760	COG0528	UMP kinase activity
YC6258_RS11765	COG0233	cytoplasmic translational termination
YC6258_RS11780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
YC6258_RS11790	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YC6258_RS11800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YC6258_RS11805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YC6258_RS11810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YC6258_RS11815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YC6258_RS11820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YC6258_RS11840	COG0037	tRNA processing
YC6258_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS11870	COG4191	Histidine kinase
YC6258_RS11880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YC6258_RS11890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YC6258_RS11895	COG0372	Belongs to the citrate synthase family
YC6258_RS11900	COG2079	MmgE PrpD family protein
YC6258_RS11915	COG0488	(ABC) transporter
YC6258_RS11920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YC6258_RS11940	COG1492	cobalamin metabolic process
YC6258_RS11975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YC6258_RS11995	COG0450	alkyl hydroperoxide reductase
YC6258_RS12000	COG0583	DNA-binding transcription factor activity
YC6258_RS12030	COG2382	esterase
YC6258_RS12035	COG1629	transport
YC6258_RS12035	COG4774	siderophore transport
YC6258_RS12075	COG3209	COG3209 Rhs family protein
YC6258_RS12100	COG3209	COG3209 Rhs family protein
YC6258_RS12115	COG3209	COG3209 Rhs family protein
YC6258_RS12235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS12260	COG0504	CTP synthase activity
YC6258_RS12280	COG3739	integral membrane protein
YC6258_RS12290	COG1609	Transcriptional regulator
YC6258_RS12310	COG3842	ATPase activity
YC6258_RS12315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YC6258_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS12335	COG1535	isochorismatase
YC6258_RS12335	COG3433	isochorismatase activity
YC6258_RS12340	COG1021	2,3-dihydroxybenzoate-AMP ligase
YC6258_RS12345	COG1169	isochorismate synthase
YC6258_RS12350	COG4592	Periplasmic binding protein
YC6258_RS12375	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
YC6258_RS12395	COG2721	sulfolactate sulfo-lyase activity
YC6258_RS12475	COG1185	polyribonucleotide nucleotidyltransferase activity
YC6258_RS12535	COG0346	lactoylglutathione lyase activity
YC6258_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS12655	COG0583	DNA-binding transcription factor activity
YC6258_RS12660	COG0653	protein targeting
YC6258_RS12665	COG3039	Transposase
YC6258_RS12705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YC6258_RS12750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YC6258_RS12770	COG5002	protein histidine kinase activity
YC6258_RS12770	COG0784	Response regulator, receiver
YC6258_RS12770	COG2205	protein histidine kinase activity
YC6258_RS12795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YC6258_RS12800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS12810	COG3720	iron ion transport
YC6258_RS12815	COG4206	TonB-dependent receptor
YC6258_RS12825	COG4783	chaperone-mediated protein folding
YC6258_RS12835	COG4335	DNA alkylation repair
YC6258_RS12855	COG1605	Chorismate mutase
YC6258_RS12860	COG1120	ATPase activity
YC6258_RS12865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS12870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS12890	COG1803	Methylglyoxal synthase
YC6258_RS12905	COG0545	Peptidyl-prolyl cis-trans isomerase
YC6258_RS12915	COG0840	transmembrane signaling receptor activity
YC6258_RS12945	COG3101	peptidyl-lysine hydroxylation
YC6258_RS12950	COG2084	Dehydrogenase
YC6258_RS12955	COG0513	Belongs to the DEAD box helicase family
YC6258_RS12960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YC6258_RS12960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YC6258_RS12965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YC6258_RS12980	COG0436	Aminotransferase
YC6258_RS12985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YC6258_RS12995	COG3769	mannosylglycerate metabolic process
YC6258_RS13000	COG1215	transferase activity, transferring glycosyl groups
YC6258_RS13020	COG2832	Protein of unknown function (DUF454)
YC6258_RS13025	COG0508	dehydrogenase complex catalyzes the overall conversion of
YC6258_RS13040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YC6258_RS13045	COG1737	Transcriptional regulator
YC6258_RS13055	COG0363	glucosamine-6-phosphate deaminase activity
YC6258_RS13070	COG0800	Aldolase
YC6258_RS13080	COG1640	4-alpha-glucanotransferase
YC6258_RS13085	COG3842	ATPase activity
YC6258_RS13095	COG1090	epimerase
YC6258_RS13100	COG1131	(ABC) transporter
YC6258_RS13105	COG0842	Transport permease protein
YC6258_RS13120	COG0443	Heat shock 70 kDa protein
YC6258_RS13150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YC6258_RS13155	COG0066	3-isopropylmalate dehydratase activity
YC6258_RS13160	COG0473	3-isopropylmalate dehydrogenase activity
YC6258_RS13180	COG0135	phosphoribosylanthranilate isomerase activity
YC6258_RS13190	COG0159	tryptophan synthase activity
YC6258_RS13200	COG0285	dihydrofolate synthase activity
YC6258_RS13210	COG1286	toxin biosynthetic process
YC6258_RS13225	COG0714	Associated with various cellular activities
YC6258_RS13260	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
YC6258_RS13260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YC6258_RS13275	COG3509	depolymerase
YC6258_RS13275	COG3693	PFAM glycoside hydrolase, family 10
YC6258_RS13320	COG2059	Chromate
YC6258_RS13330	COG0494	nUDIX hydrolase
YC6258_RS13335	COG0300	oxidoreductase activity
YC6258_RS13350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YC6258_RS13370	COG0745	RESPONSE REGULATOR receiver
YC6258_RS13385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS13435	COG3842	ATPase activity
YC6258_RS13440	COG1175	transmembrane transport
YC6258_RS13445	COG0395	ABC-type sugar transport system, permease component
YC6258_RS13460	COG3345	alpha-galactosidase
YC6258_RS13470	COG0456	acetyltransferase
YC6258_RS13470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
YC6258_RS13475	COG0583	DNA-binding transcription factor activity
YC6258_RS13480	COG1653	transport
YC6258_RS13495	COG0366	Alpha amylase catalytic
YC6258_RS13500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YC6258_RS13505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YC6258_RS13510	COG1869	D-ribose catabolic process
YC6258_RS13515	COG1129	ABC transporter
YC6258_RS13520	COG1172	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS13525	COG1879	ABC-type sugar transport system periplasmic component
YC6258_RS13530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YC6258_RS13535	COG1609	Transcriptional regulator
YC6258_RS13545	COG0625	glutathione transferase activity
YC6258_RS13605	COG0583	DNA-binding transcription factor activity
YC6258_RS13640	COG1024	Enoyl-CoA hydratase
YC6258_RS13645	COG1024	Enoyl-CoA hydratase
YC6258_RS13650	COG3425	synthase
YC6258_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS13655	COG4221	oxidoreductase activity
YC6258_RS13655	COG3321	synthase
YC6258_RS13655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS13660	COG3321	synthase
YC6258_RS13660	COG4221	oxidoreductase activity
YC6258_RS13660	COG0300	oxidoreductase activity
YC6258_RS13660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS13670	COG4221	oxidoreductase activity
YC6258_RS13670	COG3321	synthase
YC6258_RS13670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS13675	COG4221	oxidoreductase activity
YC6258_RS13675	COG3321	synthase
YC6258_RS13675	COG0300	oxidoreductase activity
YC6258_RS13675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS13695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS13700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YC6258_RS13715	COG1609	Transcriptional regulator
YC6258_RS13725	COG1105	Belongs to the carbohydrate kinase PfkB family
YC6258_RS13735	COG3706	GGDEF domain
YC6258_RS13745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YC6258_RS13750	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS13755	COG5285	phytanoyl-CoA dioxygenase
YC6258_RS13760	COG0527	aspartate kinase activity
YC6258_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS13775	COG1846	Transcriptional regulator
YC6258_RS13780	COG0386	Belongs to the glutathione peroxidase family
YC6258_RS13785	COG0402	S-adenosylhomocysteine deaminase activity
YC6258_RS13820	COG3530	Putative quorum-sensing-regulated virulence factor
YC6258_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS13865	COG0729	surface antigen
YC6258_RS13870	COG2862	Uncharacterized protein family, UPF0114
YC6258_RS13905	COG2198	Histidine kinase
YC6258_RS13905	COG0643	Histidine kinase
YC6258_RS13905	COG0784	Response regulator, receiver
YC6258_RS13915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YC6258_RS13925	COG1192	Involved in chromosome partitioning
YC6258_RS13940	COG0835	chemotaxis
YC6258_RS13950	COG2853	Lipoprotein
YC6258_RS13960	COG0745	RESPONSE REGULATOR receiver
YC6258_RS13970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YC6258_RS13980	COG2062	phosphohistidine phosphatase, SixA
YC6258_RS13985	COG0596	Alpha beta hydrolase
YC6258_RS14000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YC6258_RS14025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YC6258_RS14035	COG2207	Transcriptional regulator
YC6258_RS14050	COG1393	Belongs to the ArsC family
YC6258_RS14060	COG0110	maltose O-acetyltransferase activity
YC6258_RS14095	COG0271	Belongs to the BolA IbaG family
YC6258_RS14110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YC6258_RS14115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
YC6258_RS14120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
YC6258_RS14125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
YC6258_RS14130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YC6258_RS14135	COG0072	phenylalanine-tRNA ligase activity
YC6258_RS14140	COG0776	regulation of translation
YC6258_RS14160	COG1595	DNA-templated transcription, initiation
YC6258_RS14180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YC6258_RS14205	COG2986	histidine ammonia-lyase
YC6258_RS14210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YC6258_RS14220	COG0402	S-adenosylhomocysteine deaminase activity
YC6258_RS14225	COG0217	transcriptional regulatory protein
YC6258_RS14235	COG2873	o-acetylhomoserine
YC6258_RS14245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
YC6258_RS14250	COG0420	3'-5' exonuclease activity
YC6258_RS14255	COG0419	ATPase involved in DNA repair
YC6258_RS14270	COG0484	heat shock protein binding
YC6258_RS14280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YC6258_RS14295	COG0308	aminopeptidase N
YC6258_RS14300	COG3130	regulation of translation
YC6258_RS14305	COG2116	formate transmembrane transporter activity
YC6258_RS14330	COG1233	COG1233 Phytoene dehydrogenase and related
YC6258_RS14345	COG1466	dna polymerase III delta subunit
YC6258_RS14355	COG0495	leucyl-tRNA aminoacylation
YC6258_RS14365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YC6258_RS14390	COG0023	Translation Initiation Factor
YC6258_RS14415	COG4536	flavin adenine dinucleotide binding
YC6258_RS14420	COG4137	Cytochrome C assembly protein
YC6258_RS14425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YC6258_RS14430	COG1522	sequence-specific DNA binding
YC6258_RS14445	COG0745	RESPONSE REGULATOR receiver
YC6258_RS14450	COG0519	Catalyzes the synthesis of GMP from XMP
YC6258_RS14465	COG1555	photosystem II stabilization
YC6258_RS14470	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
YC6258_RS14475	COG0540	Belongs to the ATCase OTCase family
YC6258_RS14535	COG1448	Aminotransferase
YC6258_RS14565	COG1678	Uncharacterized ACR, COG1678
YC6258_RS14580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YC6258_RS14585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YC6258_RS14610	COG2871	sodium ion transport
YC6258_RS14615	COG1477	protein flavinylation
YC6258_RS14625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YC6258_RS14630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YC6258_RS14645	COG1530	ribonuclease E activity
YC6258_RS14660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YC6258_RS14660	COG0616	signal peptide processing
YC6258_RS14665	COG0424	maF-like protein
YC6258_RS14670	COG1399	metal-binding, possibly nucleic acid-binding protein
YC6258_RS14675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YC6258_RS14680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS14690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS14695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YC6258_RS14705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YC6258_RS14710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YC6258_RS14745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YC6258_RS14760	COG1074	ATP-dependent DNA helicase activity
YC6258_RS14770	COG0730	response to heat
YC6258_RS14780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YC6258_RS14785	COG0583	DNA-binding transcription factor activity
YC6258_RS14810	COG0835	chemotaxis
YC6258_RS14810	COG0784	Response regulator, receiver
YC6258_RS14820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YC6258_RS14845	COG0741	lytic transglycosylase activity
YC6258_RS14860	COG0488	(ABC) transporter
YC6258_RS14880	COG0183	Belongs to the thiolase family
YC6258_RS14900	COG2009	succinate dehydrogenase
YC6258_RS14905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YC6258_RS14910	COG1053	succinate dehydrogenase
YC6258_RS14965	COG0326	Molecular chaperone. Has ATPase activity
YC6258_RS15000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YC6258_RS15005	COG2850	peptidyl-arginine hydroxylation
YC6258_RS15015	COG2915	High frequency lysogenization protein hflD homolog
YC6258_RS15020	COG0482	sulfurtransferase activity
YC6258_RS15025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
YC6258_RS15030	COG1187	pseudouridine synthase activity
YC6258_RS15040	COG1278	Cold shock
YC6258_RS15045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YC6258_RS15050	COG0542	response to heat
YC6258_RS15055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YC6258_RS15060	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
YC6258_RS15065	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
YC6258_RS15070	COG1674	ftsk spoiiie
YC6258_RS15075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
YC6258_RS15080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YC6258_RS15085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YC6258_RS15090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YC6258_RS15100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YC6258_RS15110	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YC6258_RS15130	COG0616	signal peptide processing
YC6258_RS15135	COG0741	lytic transglycosylase activity
YC6258_RS15135	COG1388	LysM domain
YC6258_RS15145	COG0328	RNA-DNA hybrid ribonuclease activity
YC6258_RS15150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YC6258_RS15165	COG0667	Aldo Keto reductase
YC6258_RS15180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
YC6258_RS15210	COG0714	Associated with various cellular activities
YC6258_RS15225	COG0167	dihydroorotate dehydrogenase activity
YC6258_RS15230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YC6258_RS15240	COG5002	protein histidine kinase activity
YC6258_RS15240	COG2205	protein histidine kinase activity
YC6258_RS15240	COG0784	Response regulator, receiver
YC6258_RS15245	COG5001	Diguanylate cyclase
YC6258_RS15245	COG4251	negative regulation of phosphorylation
YC6258_RS15245	COG3706	GGDEF domain
YC6258_RS15245	COG2203	Gaf domain
YC6258_RS15250	COG5002	protein histidine kinase activity
YC6258_RS15250	COG0784	Response regulator, receiver
YC6258_RS15250	COG2205	protein histidine kinase activity
YC6258_RS15330	COG4221	oxidoreductase activity
YC6258_RS15345	COG0454	-acetyltransferase
YC6258_RS15385	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS15410	COG4615	Cyclic peptide transporter
YC6258_RS15465	COG4974	Belongs to the 'phage' integrase family
YC6258_RS15520	COG1609	Transcriptional regulator
YC6258_RS15525	COG1486	melibiose metabolic process
YC6258_RS15535	COG0395	ABC-type sugar transport system, permease component
YC6258_RS15540	COG1175	transmembrane transport
YC6258_RS15620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YC6258_RS15635	COG0330	HflC and HflK could
YC6258_RS15705	COG1609	Transcriptional regulator
YC6258_RS15720	COG1175	transmembrane transport
YC6258_RS15725	COG0395	ABC-type sugar transport system, permease component
YC6258_RS15770	COG4774	siderophore transport
YC6258_RS15775	COG1120	ATPase activity
YC6258_RS15780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YC6258_RS15850	COG4974	Belongs to the 'phage' integrase family
YC6258_RS15955	COG3693	PFAM glycoside hydrolase, family 10
YC6258_RS15975	COG0454	-acetyltransferase
YC6258_RS15985	COG2226	methyltransferase
YC6258_RS15995	COG3237	CsbD-like
YC6258_RS16005	COG3459	Glycosyltransferase 36 associated
YC6258_RS16025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YC6258_RS16035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YC6258_RS16100	COG3795	YCII-related domain
YC6258_RS16110	COG5507	3-demethylubiquinone-9 3-methyltransferase
YC6258_RS16115	COG4941	Belongs to the sigma-70 factor family
YC6258_RS16120	COG0640	Transcriptional regulator
YC6258_RS16130	COG0431	NADPH-dependent FMN reductase
YC6258_RS16135	COG0798	PFAM Bile acid sodium symporter
YC6258_RS16215	COG1484	DNA-dependent DNA replication
YC6258_RS16235	COG0583	DNA-binding transcription factor activity
YC6258_RS16250	COG4221	oxidoreductase activity
YC6258_RS16250	COG3321	synthase
YC6258_RS16250	COG0300	oxidoreductase activity
YC6258_RS16250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS16255	COG0300	oxidoreductase activity
YC6258_RS16255	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16255	COG3321	synthase
YC6258_RS16255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16260	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS16260	COG3321	synthase
YC6258_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16260	COG0300	oxidoreductase activity
YC6258_RS16270	COG0456	acetyltransferase
YC6258_RS16320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS16375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS16385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS16385	COG2070	2-Nitropropane dioxygenase
YC6258_RS16390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS16390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS16390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16390	COG3321	synthase
YC6258_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16395	COG3321	synthase
YC6258_RS16395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16395	COG4221	oxidoreductase activity
YC6258_RS16410	COG0300	oxidoreductase activity
YC6258_RS16410	COG4221	oxidoreductase activity
YC6258_RS16410	COG3321	synthase
YC6258_RS16410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS16415	COG3321	synthase
YC6258_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16415	COG4221	oxidoreductase activity
YC6258_RS16415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16445	COG3321	synthase
YC6258_RS16490	COG0439	Biotin carboxylase
YC6258_RS16505	COG1116	anion transmembrane transporter activity
YC6258_RS16510	COG2011	ABC-type metal ion transport system permease component
YC6258_RS16550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YC6258_RS16575	COG0583	DNA-binding transcription factor activity
YC6258_RS16580	COG0667	Aldo Keto reductase
YC6258_RS16665	COG2010	Cytochrome c
YC6258_RS16680	COG2070	2-Nitropropane dioxygenase
YC6258_RS16680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS16710	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16710	COG3321	synthase
YC6258_RS16710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS16710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS16715	COG3321	synthase
YC6258_RS16715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS16715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS16715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16715	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16720	COG0300	oxidoreductase activity
YC6258_RS16720	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS16720	COG3321	synthase
YC6258_RS16720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS16735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
YC6258_RS16740	COG1435	thymidine kinase activity
YC6258_RS16750	COG1024	Enoyl-CoA hydratase
YC6258_RS16760	COG0670	Belongs to the BI1 family
YC6258_RS16765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YC6258_RS16780	COG2920	part of a sulfur-relay system
YC6258_RS16785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YC6258_RS16795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YC6258_RS16795	COG1648	precorrin-2 dehydrogenase activity
YC6258_RS16920	COG4974	Belongs to the 'phage' integrase family
YC6258_RS16945	COG0322	excinuclease ABC activity
YC6258_RS16950	COG2197	response regulator
YC6258_RS16955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
YC6258_RS16990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YC6258_RS16995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
YC6258_RS17010	COG0811	peptide transport
YC6258_RS17025	COG1136	(ABC) transporter
YC6258_RS17030	COG4591	ABC-type transport system involved in lipoprotein release permease component
YC6258_RS17045	COG1199	ATP-dependent helicase activity
YC6258_RS17050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YC6258_RS17055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YC6258_RS17065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YC6258_RS17075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YC6258_RS17080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YC6258_RS17085	COG0740	serine-type endopeptidase activity
YC6258_RS17090	COG0544	peptidyl-prolyl cis-trans isomerase activity
YC6258_RS17115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YC6258_RS17120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YC6258_RS17135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YC6258_RS17150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YC6258_RS17160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YC6258_RS17160	COG3008	intermembrane lipid transfer
YC6258_RS17165	COG2995	paraquat-inducible protein a
YC6258_RS17170	COG2995	paraquat-inducible protein a
YC6258_RS17185	COG0456	acetyltransferase
YC6258_RS17225	COG1459	type II secretion system
YC6258_RS17235	COG0745	RESPONSE REGULATOR receiver
YC6258_RS17260	COG0432	Pfam Uncharacterised protein family UPF0047
YC6258_RS17270	COG2813	Specifically methylates the guanine in position
YC6258_RS17290	COG0776	regulation of translation
YC6258_RS17295	COG5265	(ABC) transporter
YC6258_RS17300	COG0564	pseudouridine synthase activity
YC6258_RS17315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YC6258_RS17320	COG0628	permease
YC6258_RS17330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YC6258_RS17335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YC6258_RS17345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YC6258_RS17355	COG0489	protein tyrosine kinase activity
YC6258_RS17360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YC6258_RS17360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YC6258_RS17365	COG4657	Part of a membrane complex involved in electron transport
YC6258_RS17370	COG2878	Part of a membrane complex involved in electron transport
YC6258_RS17375	COG4656	Part of a membrane complex involved in electron transport
YC6258_RS17380	COG4658	electron transport chain
YC6258_RS17390	COG4660	Part of a membrane complex involved in electron transport
YC6258_RS17395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YC6258_RS17425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YC6258_RS17425	COG3323	Protein of unknown function (DUF1653)
YC6258_RS17445	COG0745	RESPONSE REGULATOR receiver
YC6258_RS17465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YC6258_RS17470	COG1121	(ABC) transporter
YC6258_RS17475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YC6258_RS17480	COG0735	belongs to the Fur family
YC6258_RS17485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YC6258_RS17505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YC6258_RS17510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YC6258_RS17540	COG0277	FAD linked oxidase domain protein
YC6258_RS17550	COG1238	metal cluster binding
YC6258_RS17555	COG1132	(ABC) transporter
YC6258_RS17560	COG1132	(ABC) transporter
YC6258_RS17570	COG2999	glutathione oxidoreductase activity
YC6258_RS17575	COG0546	phosphoglycolate phosphatase activity
YC6258_RS17600	COG1024	Enoyl-CoA hydratase
YC6258_RS17605	COG1846	Transcriptional regulator
YC6258_RS17630	COG0247	lactate metabolic process
YC6258_RS17630	COG0277	FAD linked oxidase domain protein
YC6258_RS17635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
YC6258_RS17640	COG1914	H( )-stimulated, divalent metal cation uptake system
YC6258_RS17665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YC6258_RS17675	COG2201	protein-glutamate methylesterase activity
YC6258_RS17685	COG3706	GGDEF domain
YC6258_RS17695	COG0693	protein deglycase activity
YC6258_RS17710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
YC6258_RS17730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YC6258_RS17735	COG0011	TIGRFAM Protein of
YC6258_RS17740	COG0450	alkyl hydroperoxide reductase
YC6258_RS17745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YC6258_RS17750	COG4181	ATPase activity
YC6258_RS17765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YC6258_RS17775	COG2149	membrane
YC6258_RS17815	COG1802	Transcriptional regulator
YC6258_RS17820	COG0589	response to stress
YC6258_RS17825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS17830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
YC6258_RS17835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YC6258_RS17855	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
YC6258_RS17895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS17925	COG0602	queuosine metabolic process
YC6258_RS17930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YC6258_RS17930	COG1328	CTP reductase activity
YC6258_RS17940	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YC6258_RS17945	COG2814	Major facilitator Superfamily
YC6258_RS17955	COG1064	alcohol dehydrogenase
YC6258_RS17965	COG2186	Transcriptional regulator
YC6258_RS17975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
YC6258_RS17990	COG0246	Mannitol dehydrogenase
YC6258_RS18040	COG1280	lysine exporter protein (LysE YggA)
YC6258_RS18065	COG3951	Flagellar rod assembly protein muramidase FlgJ
YC6258_RS18065	COG1705	Flagellar rod assembly protein muramidase FlgJ
YC6258_RS18085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YC6258_RS18125	COG5520	Belongs to the glycosyl hydrolase 30 family
YC6258_RS18125	COG4447	cellulose binding
YC6258_RS18125	COG3291	Pkd domain containing protein
YC6258_RS18145	COG1045	serine acetyltransferase
YC6258_RS18165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YC6258_RS18175	COG1862	Preprotein translocase
YC6258_RS18180	COG0343	queuine tRNA-ribosyltransferase activity
YC6258_RS18220	COG1349	DNA-binding transcription factor activity
YC6258_RS18265	COG2814	Major facilitator Superfamily
YC6258_RS18280	COG3842	ATPase activity
YC6258_RS18285	COG0395	ABC-type sugar transport system, permease component
YC6258_RS18290	COG1175	transmembrane transport
YC6258_RS18310	COG2205	protein histidine kinase activity
YC6258_RS18325	COG1619	proteins homologs of microcin C7 resistance protein MccF
YC6258_RS18340	COG0667	Aldo Keto reductase
YC6258_RS18365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YC6258_RS18380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YC6258_RS18385	COG0583	DNA-binding transcription factor activity
YC6258_RS18430	COG1801	Protein of unknown function DUF72
YC6258_RS18450	COG1132	(ABC) transporter
YC6258_RS18460	COG2162	N-hydroxyarylamine O-acetyltransferase activity
YC6258_RS18470	COG1139	Iron-sulfur cluster binding protein
YC6258_RS18480	COG2186	Transcriptional regulator
YC6258_RS18500	COG1643	Atp-dependent helicase
YC6258_RS18505	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS18510	COG0121	glutamine amidotransferase
YC6258_RS18530	COG2983	Belongs to the UPF0260 family
YC6258_RS18535	COG3100	YcgL domain-containing protein
YC6258_RS18545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YC6258_RS18550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YC6258_RS18560	COG3940	Belongs to the glycosyl hydrolase 43 family
YC6258_RS18570	COG0602	queuosine metabolic process
YC6258_RS18585	COG0446	pyridine nucleotide-disulphide oxidoreductase
YC6258_RS18595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YC6258_RS18600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
YC6258_RS18605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YC6258_RS18615	COG0288	reversible hydration of carbon dioxide
YC6258_RS18625	COG1162	GTPase activity
YC6258_RS18630	COG0726	polysaccharide deacetylase
YC6258_RS18635	COG3012	SEC-C Motif Domain Protein
YC6258_RS18640	COG1573	uracil-dna glycosylase
YC6258_RS18650	COG2311	Membrane
YC6258_RS18740	COG3693	PFAM glycoside hydrolase, family 10
YC6258_RS18745	COG3693	PFAM glycoside hydrolase, family 10
YC6258_RS18745	COG3509	depolymerase
YC6258_RS18770	COG5520	Belongs to the glycosyl hydrolase 30 family
YC6258_RS18800	COG2133	pyrroloquinoline quinone binding
YC6258_RS18840	COG2124	cytochrome p450
YC6258_RS18840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YC6258_RS18845	COG0753	catalase activity
YC6258_RS18870	COG1116	anion transmembrane transporter activity
YC6258_RS18870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YC6258_RS18875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YC6258_RS18880	COG1116	anion transmembrane transporter activity
YC6258_RS18890	COG2223	nitrite transmembrane transporter activity
YC6258_RS18910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
YC6258_RS18920	COG1115	amino acid carrier protein
YC6258_RS18925	COG0525	valine-tRNA ligase activity
YC6258_RS18950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
YC6258_RS18955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YC6258_RS18965	COG0215	cysteine-tRNA ligase activity
YC6258_RS18970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
YC6258_RS18975	COG2835	tetraacyldisaccharide 4'-kinase activity
YC6258_RS18985	COG0668	transmembrane transport
YC6258_RS19010	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YC6258_RS19035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YC6258_RS19040	COG1053	succinate dehydrogenase
YC6258_RS19075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YC6258_RS19090	COG0534	Mate efflux family protein
YC6258_RS19120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YC6258_RS19140	COG1086	Polysaccharide biosynthesis protein
YC6258_RS19150	COG0346	lactoylglutathione lyase activity
YC6258_RS19155	COG0667	Aldo Keto reductase
YC6258_RS19175	COG1987	bacterial-type flagellum assembly
YC6258_RS19210	COG0784	Response regulator, receiver
YC6258_RS19210	COG2198	Histidine kinase
YC6258_RS19210	COG2205	protein histidine kinase activity
YC6258_RS19225	COG2201	protein-glutamate methylesterase activity
YC6258_RS19230	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
YC6258_RS19250	COG0643	Histidine kinase
YC6258_RS19250	COG2198	Histidine kinase
YC6258_RS19255	COG0745	RESPONSE REGULATOR receiver
YC6258_RS19290	COG1677	Flagellar hook-basal body complex protein FliE
YC6258_RS19335	COG3940	Belongs to the glycosyl hydrolase 43 family
YC6258_RS19340	COG1609	Transcriptional regulator
YC6258_RS19350	COG0395	ABC-type sugar transport system, permease component
YC6258_RS19355	COG1175	transmembrane transport
YC6258_RS19370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YC6258_RS19375	COG1334	flagellar protein FlaG
YC6258_RS19395	COG0686	Belongs to the AlaDH PNT family
YC6258_RS19405	COG1181	Belongs to the D-alanine--D-alanine ligase family
YC6258_RS19410	COG3038	cytochrome b561
YC6258_RS19415	COG1609	Transcriptional regulator
YC6258_RS19425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
YC6258_RS19435	COG5001	Diguanylate cyclase
YC6258_RS19435	COG3300	MHYT domain
YC6258_RS19440	COG0826	peptidase U32
YC6258_RS19485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YC6258_RS19490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YC6258_RS19495	COG2962	Rard protein
YC6258_RS19505	COG1362	aminopeptidase activity
YC6258_RS19525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YC6258_RS19530	COG0512	Glutamine amidotransferase of anthranilate synthase
YC6258_RS19535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YC6258_RS19540	COG0134	indole-3-glycerol-phosphate synthase activity
YC6258_RS19555	COG1765	OsmC-like protein
YC6258_RS19560	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YC6258_RS19570	COG2890	protein-(glutamine-N5) methyltransferase activity
YC6258_RS19575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YC6258_RS19580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YC6258_RS19590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
YC6258_RS19595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
YC6258_RS19600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YC6258_RS19605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
YC6258_RS19610	COG0193	aminoacyl-tRNA hydrolase activity
YC6258_RS19615	COG0012	GTP binding
YC6258_RS19660	COG2204	response regulator
YC6258_RS19670	COG0788	formyltetrahydrofolate deformylase activity
YC6258_RS19695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YC6258_RS19700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
YC6258_RS19705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YC6258_RS19710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YC6258_RS19715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YC6258_RS19720	COG0142	geranyltranstransferase activity
YC6258_RS19745	COG2814	Major facilitator Superfamily
YC6258_RS19760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
YC6258_RS19780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YC6258_RS19785	COG0287	Prephenate dehydrogenase
YC6258_RS19790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YC6258_RS19810	COG0402	S-adenosylhomocysteine deaminase activity
YC6258_RS19815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS19830	COG3706	GGDEF domain
YC6258_RS19835	COG0084	hydrolase, TatD family'
YC6258_RS19840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YC6258_RS19845	COG0259	pyridoxamine-phosphate oxidase activity
YC6258_RS19865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
YC6258_RS19870	COG0009	L-threonylcarbamoyladenylate synthase
YC6258_RS19875	COG0613	PHP domain protein
YC6258_RS19880	COG2350	Protein conserved in bacteria
YC6258_RS19895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YC6258_RS19900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
YC6258_RS19900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS19905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YC6258_RS19920	COG0671	phosphoesterase, PA-phosphatase related
YC6258_RS19945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YC6258_RS19950	COG0585	pseudouridine synthase activity
YC6258_RS19965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
YC6258_RS19990	COG4608	Belongs to the ABC transporter superfamily
YC6258_RS20000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YC6258_RS20010	COG2267	carboxylic ester hydrolase activity
YC6258_RS20020	COG2267	carboxylic ester hydrolase activity
YC6258_RS20025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YC6258_RS20035	COG0175	sulfate reduction
YC6258_RS20050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YC6258_RS20055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YC6258_RS20060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YC6258_RS20065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YC6258_RS20070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YC6258_RS20095	COG1137	ATPase activity
YC6258_RS20115	COG1660	Displays ATPase and GTPase activities
YC6258_RS20125	COG2239	Acts as a magnesium transporter
YC6258_RS20130	COG3028	Belongs to the UPF0307 family
YC6258_RS20140	COG4172	Belongs to the ABC transporter superfamily
YC6258_RS20145	COG4239	(ABC) transporter, permease
YC6258_RS20150	COG4174	ABC transporter (Permease)
YC6258_RS20155	COG4166	transmembrane transport
YC6258_RS20160	COG0742	ribosomal rna small subunit methyltransferase
YC6258_RS20170	COG1968	undecaprenyl-diphosphatase activity
YC6258_RS20175	COG1214	PFAM Peptidase M22, glycoprotease
YC6258_RS20185	COG0563	adenylate kinase activity
YC6258_RS20205	COG0459	protein refolding
YC6258_RS20210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YC6258_RS20220	COG1666	GTP binding
YC6258_RS20240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
YC6258_RS20255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YC6258_RS20260	COG0509	glycine decarboxylation via glycine cleavage system
YC6258_RS20265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YC6258_RS20265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YC6258_RS20275	COG0367	asparagine synthase
YC6258_RS20310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YC6258_RS20320	COG1929	Belongs to the glycerate kinase type-1 family
YC6258_RS20325	COG0366	Alpha amylase catalytic
YC6258_RS20355	COG3123	guanosine phosphorylase activity
YC6258_RS20360	COG0668	transmembrane transport
YC6258_RS20365	COG3108	Peptidase M15
YC6258_RS20420	COG3254	rhamnose metabolic process
YC6258_RS20430	COG1172	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS20435	COG1129	ABC transporter
YC6258_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS20450	COG3347	Dehydrogenase
YC6258_RS20455	COG4952	isomerase
YC6258_RS20490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YC6258_RS20490	COG2169	Transcriptional regulator
YC6258_RS20500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YC6258_RS20520	COG1280	lysine exporter protein (LysE YggA)
YC6258_RS20550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YC6258_RS20555	COG0625	glutathione transferase activity
YC6258_RS20560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YC6258_RS20565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YC6258_RS20570	COG0302	gtp cyclohydrolase
YC6258_RS20575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YC6258_RS20605	COG2813	Specifically methylates the guanine in position
YC6258_RS20615	COG3118	belongs to the thioredoxin family
YC6258_RS20620	COG1025	Belongs to the peptidase M16 family
YC6258_RS20635	COG1024	Enoyl-CoA hydratase
YC6258_RS20640	COG2925	Exonuclease
YC6258_RS20710	COG2207	Transcriptional regulator
YC6258_RS20710	COG1917	Cupin 2, conserved barrel domain protein
YC6258_RS20715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YC6258_RS20725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
YC6258_RS20735	COG1278	Cold shock
YC6258_RS20765	COG2070	2-Nitropropane dioxygenase
YC6258_RS20765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS20770	COG0366	Alpha amylase catalytic
YC6258_RS20775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YC6258_RS20840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YC6258_RS20845	COG0830	nickel cation binding
YC6258_RS20850	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
YC6258_RS20855	COG0804	urea catabolic process
YC6258_RS20860	COG0832	Belongs to the urease beta subunit family
YC6258_RS20865	COG0831	urea catabolic process
YC6258_RS20870	COG0829	nickel cation binding
YC6258_RS20925	COG0745	RESPONSE REGULATOR receiver
YC6258_RS20930	COG2198	Histidine kinase
YC6258_RS20930	COG2205	protein histidine kinase activity
YC6258_RS20930	COG0784	Response regulator, receiver
YC6258_RS20930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS20935	COG2818	Glycosylase
YC6258_RS20950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YC6258_RS20955	COG1309	transcriptional regulator
YC6258_RS20960	COG1119	ATPase activity
YC6258_RS20975	COG0564	pseudouridine synthase activity
YC6258_RS20990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YC6258_RS21015	COG3089	Belongs to the UPF0270 family
YC6258_RS21025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YC6258_RS21030	COG3115	cell septum assembly
YC6258_RS21060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
YC6258_RS21075	COG4133	protoheme IX ABC transporter activity
YC6258_RS21085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YC6258_RS21095	COG1653	transport
YC6258_RS21100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
YC6258_RS21125	COG1322	Protein conserved in bacteria
YC6258_RS21135	COG0252	asparaginase activity
YC6258_RS21145	COG1643	Atp-dependent helicase
YC6258_RS21150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YC6258_RS21170	COG0795	lipopolysaccharide-transporting ATPase activity
YC6258_RS21175	COG0795	lipopolysaccharide-transporting ATPase activity
YC6258_RS21180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YC6258_RS21185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YC6258_RS21190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YC6258_RS21195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YC6258_RS21200	COG2226	methyltransferase
YC6258_RS21220	COG2900	Belongs to the SlyX family
YC6258_RS21230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YC6258_RS21230	COG0617	tRNA 3'-terminal CCA addition
YC6258_RS21230	COG0517	IMP dehydrogenase activity
YC6258_RS21235	COG2166	iron-sulfur cluster assembly
YC6258_RS21240	COG2151	metal-sulfur cluster biosynthetic enzyme
YC6258_RS21250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YC6258_RS21255	COG0719	Fe-S assembly protein
YC6258_RS21260	COG0396	ATPase activity
YC6258_RS21265	COG0719	Fe-S assembly protein
YC6258_RS21270	COG1104	cysteine desulfurase activity
YC6258_RS21300	COG1706	bacterial-type flagellum-dependent cell motility
YC6258_RS21305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YC6258_RS21315	COG4786	Flagellar basal body rod
YC6258_RS21340	COG1815	bacterial-type flagellum-dependent cell motility
YC6258_RS21350	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS21365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
YC6258_RS21365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS21365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS21365	COG3321	synthase
YC6258_RS21375	COG1773	rubredoxin
YC6258_RS21405	COG0784	Response regulator, receiver
YC6258_RS21405	COG0835	chemotaxis
YC6258_RS21430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YC6258_RS21435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YC6258_RS21440	COG2040	homocysteine
YC6258_RS21445	COG0833	amino acid
YC6258_RS21455	COG1609	Transcriptional regulator
YC6258_RS21465	COG1175	transmembrane transport
YC6258_RS21470	COG0395	ABC-type sugar transport system, permease component
YC6258_RS21490	COG2738	Putative neutral zinc metallopeptidase
YC6258_RS21495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YC6258_RS21500	COG0142	geranyltranstransferase activity
YC6258_RS21510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YC6258_RS21515	COG1360	Flagellar Motor Protein
YC6258_RS21520	COG2072	flavoprotein involved in K transport
YC6258_RS21530	COG2124	cytochrome p450
YC6258_RS21565	COG1079	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS21570	COG4603	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS21575	COG3845	ABC transporter
YC6258_RS21600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YC6258_RS21605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YC6258_RS21625	COG0514	ATP-dependent DNA helicase (RecQ)
YC6258_RS21655	COG2169	Transcriptional regulator
YC6258_RS21665	COG5001	Diguanylate cyclase
YC6258_RS21665	COG1716	ATPase activity
YC6258_RS21685	COG3038	cytochrome b561
YC6258_RS21700	COG1946	Acyl-CoA thioesterase
YC6258_RS21720	COG0251	oxidation-reduction process
YC6258_RS21725	COG1523	belongs to the glycosyl hydrolase 13 family
YC6258_RS21735	COG1067	ATP-dependent peptidase activity
YC6258_RS21740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YC6258_RS21745	COG2205	protein histidine kinase activity
YC6258_RS21745	COG2198	Histidine kinase
YC6258_RS21745	COG0784	Response regulator, receiver
YC6258_RS21765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YC6258_RS21785	COG2239	Acts as a magnesium transporter
YC6258_RS21790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YC6258_RS21795	COG0435	Glutathione S-transferase
YC6258_RS21815	COG0501	Belongs to the peptidase M48B family
YC6258_RS21820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
YC6258_RS21830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YC6258_RS21835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YC6258_RS21840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YC6258_RS21845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YC6258_RS21850	COG1610	YqeY-like protein
YC6258_RS21865	COG0330	HflC and HflK could
YC6258_RS21870	COG0330	HflC and HflK could
YC6258_RS21885	COG2010	Cytochrome c
YC6258_RS21995	COG0582	viral genome integration into host DNA
YC6258_RS22010	COG2189	Belongs to the N(4) N(6)-methyltransferase family
YC6258_RS22020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YC6258_RS22070	COG2211	Major facilitator Superfamily
YC6258_RS22080	COG3706	GGDEF domain
YC6258_RS22085	COG0583	DNA-binding transcription factor activity
YC6258_RS22095	COG0625	glutathione transferase activity
YC6258_RS22105	COG0471	metal ion transport
YC6258_RS22115	COG1309	transcriptional regulator
YC6258_RS22125	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS22125	COG1454	alcohol dehydrogenase
YC6258_RS22130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YC6258_RS22135	COG1942	4-Oxalocrotonate Tautomerase
YC6258_RS22145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
YC6258_RS22150	COG1252	NADH dehydrogenase
YC6258_RS22190	COG1136	(ABC) transporter
YC6258_RS22210	COG1175	transmembrane transport
YC6258_RS22215	COG3833	ABC-type maltose transport systems, permease component
YC6258_RS22235	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YC6258_RS22260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YC6258_RS22265	COG4139	cobalamin transport
YC6258_RS22270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YC6258_RS22290	COG1172	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS22295	COG1172	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS22300	COG1129	ABC transporter
YC6258_RS22305	COG1879	ABC-type sugar transport system periplasmic component
YC6258_RS22310	COG1335	isochorismatase
YC6258_RS22325	COG2159	amidohydrolase
YC6258_RS22365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS22375	COG0604	alcohol dehydrogenase
YC6258_RS22390	COG5001	Diguanylate cyclase
YC6258_RS22390	COG3300	MHYT domain
YC6258_RS22410	COG1047	Peptidyl-prolyl cis-trans
YC6258_RS22420	COG0625	glutathione transferase activity
YC6258_RS22435	COG4953	penicillin-binding protein 1C
YC6258_RS22490	COG1203	CRISPR-associated helicase, Cas3
YC6258_RS22505	COG1802	Transcriptional regulator
YC6258_RS22510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YC6258_RS22520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS22525	COG4948	Mandelate Racemase Muconate Lactonizing
YC6258_RS22530	COG0246	Mannitol dehydrogenase
YC6258_RS22535	COG1904	glucuronate isomerase
YC6258_RS22540	COG1309	transcriptional regulator
YC6258_RS22545	COG0493	'glutamate synthase
YC6258_RS22585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YC6258_RS22590	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS22610	COG0300	oxidoreductase activity
YC6258_RS22610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS22610	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS22610	COG3321	synthase
YC6258_RS22610	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS22620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS22620	COG2070	2-Nitropropane dioxygenase
YC6258_RS22630	COG0156	8-amino-7-oxononanoate synthase activity
YC6258_RS22640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS22640	COG0300	oxidoreductase activity
YC6258_RS22640	COG4221	oxidoreductase activity
YC6258_RS22640	COG3321	synthase
YC6258_RS22655	COG2197	response regulator
YC6258_RS22680	COG0840	transmembrane signaling receptor activity
YC6258_RS22695	COG1902	pentaerythritol trinitrate reductase activity
YC6258_RS22725	COG0714	Associated with various cellular activities
YC6258_RS22745	COG2354	Protein conserved in bacteria
YC6258_RS22765	COG1054	Belongs to the UPF0176 family
YC6258_RS22780	COG0745	RESPONSE REGULATOR receiver
YC6258_RS22790	COG0643	Histidine kinase
YC6258_RS22790	COG2198	Histidine kinase
YC6258_RS22795	COG0840	transmembrane signaling receptor activity
YC6258_RS22800	COG0835	chemotaxis
YC6258_RS22810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
YC6258_RS22815	COG2201	protein-glutamate methylesterase activity
YC6258_RS22820	COG3132	Protein of unknown function, DUF480
YC6258_RS22825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
YC6258_RS22830	COG2996	Protein conserved in bacteria
YC6258_RS22840	COG0018	arginyl-trna synthetase
YC6258_RS22845	COG1132	(ABC) transporter
YC6258_RS22870	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS22890	COG3848	Pyruvate phosphate dikinase
YC6258_RS22890	COG0574	Belongs to the PEP-utilizing enzyme family
YC6258_RS22910	COG2827	Endonuclease containing a URI domain
YC6258_RS22950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YC6258_RS22950	COG2169	Transcriptional regulator
YC6258_RS22955	COG2050	protein possibly involved in aromatic compounds catabolism
YC6258_RS22960	COG0318	PFAM AMP-dependent synthetase and ligase
YC6258_RS22965	COG1441	menaquinone biosynthetic process
YC6258_RS22975	COG0596	Alpha beta hydrolase
YC6258_RS22980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
YC6258_RS22995	COG1070	Carbohydrate kinase
YC6258_RS23000	COG2115	Belongs to the xylose isomerase family
YC6258_RS23050	COG0840	transmembrane signaling receptor activity
YC6258_RS23080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YC6258_RS23100	COG0574	Belongs to the PEP-utilizing enzyme family
YC6258_RS23100	COG3848	Pyruvate phosphate dikinase
YC6258_RS23115	COG0688	phosphatidylethanolamine metabolic process
YC6258_RS23120	COG0469	pyruvate kinase activity
YC6258_RS23265	COG4555	ABC transporter
YC6258_RS23300	COG1280	lysine exporter protein (LysE YggA)
YC6258_RS23310	COG3263	regulation of cellular component size
YC6258_RS23325	COG2207	Transcriptional regulator
YC6258_RS23340	COG0745	RESPONSE REGULATOR receiver
YC6258_RS23400	COG0243	molybdopterin cofactor binding
YC6258_RS23405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YC6258_RS23410	COG5002	protein histidine kinase activity
YC6258_RS23425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YC6258_RS23430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YC6258_RS23435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YC6258_RS23440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
YC6258_RS23460	COG0714	Associated with various cellular activities
YC6258_RS23470	COG3552	Protein containing von Willebrand factor type A (VWA) domain
YC6258_RS23500	COG1131	(ABC) transporter
YC6258_RS23530	COG1131	(ABC) transporter
YC6258_RS23545	COG4302	ethanolamine ammonia-lyase activity
YC6258_RS23555	COG1185	polyribonucleotide nucleotidyltransferase activity
YC6258_RS23565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YC6258_RS23570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YC6258_RS23575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YC6258_RS23580	COG0195	Participates in both transcription termination and antitermination
YC6258_RS23585	COG0779	Required for maturation of 30S ribosomal subunits
YC6258_RS23605	COG0149	triose-phosphate isomerase activity
YC6258_RS23610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YC6258_RS23615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YC6258_RS23625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
YC6258_RS23635	COG0697	spore germination
YC6258_RS23640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YC6258_RS23645	COG0488	(ABC) transporter
YC6258_RS23660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YC6258_RS23670	COG1530	ribonuclease E activity
YC6258_RS23675	COG0424	maF-like protein
YC6258_RS23685	COG1792	Involved in formation and maintenance of cell shape
YC6258_RS23690	COG1077	Cell shape determining protein MreB Mrl
YC6258_RS23700	COG0154	amidase activity
YC6258_RS23705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YC6258_RS23710	COG1024	Enoyl-CoA hydratase
YC6258_RS23715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YC6258_RS23720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YC6258_RS23725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YC6258_RS23745	COG0156	8-amino-7-oxononanoate synthase activity
YC6258_RS23750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YC6258_RS23755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YC6258_RS23775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YC6258_RS23810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YC6258_RS23815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YC6258_RS23820	COG4191	Histidine kinase
YC6258_RS23820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YC6258_RS23825	COG1882	Formate acetyltransferase
YC6258_RS23830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS23835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YC6258_RS23845	COG0243	molybdopterin cofactor binding
YC6258_RS23880	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YC6258_RS23885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS23915	COG0175	sulfate reduction
YC6258_RS23920	COG0471	metal ion transport
YC6258_RS23920	COG3273	potassium ion transport
YC6258_RS23925	COG1218	3'(2'),5'-bisphosphate nucleotidase
YC6258_RS23930	COG1741	Belongs to the pirin family
YC6258_RS23935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YC6258_RS23940	COG2766	serine protein kinase
YC6258_RS23945	COG2718	Belongs to the UPF0229 family
YC6258_RS23950	COG2719	SpoVR family
YC6258_RS23960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YC6258_RS23970	COG0517	IMP dehydrogenase activity
YC6258_RS23970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YC6258_RS23975	COG2176	DNA-directed DNA polymerase activity
YC6258_RS23980	COG1737	Transcriptional regulator
YC6258_RS23990	COG1172	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS23995	COG1129	ABC transporter
YC6258_RS24010	COG0840	transmembrane signaling receptor activity
YC6258_RS24015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YC6258_RS24020	COG3962	Belongs to the TPP enzyme family
YC6258_RS24055	COG0583	DNA-binding transcription factor activity
YC6258_RS24060	COG3718	enzyme involved in inositol metabolism
YC6258_RS24065	COG2226	methyltransferase
YC6258_RS24070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS24100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
YC6258_RS24110	COG1183	phosphatidylcholine synthase activity
YC6258_RS24115	COG0583	DNA-binding transcription factor activity
YC6258_RS24125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YC6258_RS24135	COG0705	Rhomboid family
YC6258_RS24145	COG0730	response to heat
YC6258_RS24155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YC6258_RS24175	COG0028	Belongs to the TPP enzyme family
YC6258_RS24180	COG0281	malic enzyme
YC6258_RS24210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YC6258_RS24210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YC6258_RS24225	COG4970	Tfp pilus assembly protein FimT
YC6258_RS24265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YC6258_RS24270	COG1047	Peptidyl-prolyl cis-trans
YC6258_RS24275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YC6258_RS24280	COG0196	riboflavin kinase activity
YC6258_RS24285	COG0728	peptidoglycan biosynthetic process
YC6258_RS24290	COG0268	Binds directly to 16S ribosomal RNA
YC6258_RS24295	COG0583	DNA-binding transcription factor activity
YC6258_RS24305	COG0484	heat shock protein binding
YC6258_RS24310	COG0443	Heat shock 70 kDa protein
YC6258_RS24315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YC6258_RS24320	COG0497	DNA recombination
YC6258_RS24325	COG0534	Mate efflux family protein
YC6258_RS24340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YC6258_RS24345	COG2914	Belongs to the UPF0125 (RnfH) family
YC6258_RS24355	COG0733	neurotransmitter:sodium symporter activity
YC6258_RS24360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YC6258_RS24380	COG3311	Transcriptional regulator
YC6258_RS24405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YC6258_RS24405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YC6258_RS24425	COG2132	Multicopper oxidase
YC6258_RS24440	COG0270	DNA (cytosine-5-)-methyltransferase activity
YC6258_RS24465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS24465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS24465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS24465	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS24465	COG3321	synthase
YC6258_RS24475	COG2070	2-Nitropropane dioxygenase
YC6258_RS24475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YC6258_RS24530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YC6258_RS24760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YC6258_RS24770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YC6258_RS24770	COG0574	Belongs to the PEP-utilizing enzyme family
YC6258_RS24795	COG2204	response regulator
YC6258_RS24805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YC6258_RS24805	COG1017	nitric oxide dioxygenase activity
YC6258_RS24810	COG1120	ATPase activity
YC6258_RS24815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS24820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YC6258_RS24825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
YC6258_RS24830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
YC6258_RS24850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YC6258_RS24860	COG3507	Belongs to the glycosyl hydrolase 43 family
YC6258_RS24860	COG2382	esterase
YC6258_RS24860	COG3693	PFAM glycoside hydrolase, family 10
YC6258_RS24870	COG2307	Protein conserved in bacteria
YC6258_RS24870	COG2308	Evidence 4 Homologs of previously reported genes of
YC6258_RS24885	COG2308	Evidence 4 Homologs of previously reported genes of
YC6258_RS24890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YC6258_RS24895	COG0203	ribosomal protein L17
YC6258_RS24900	COG0202	RNA polymerase activity
YC6258_RS24905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YC6258_RS24910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YC6258_RS24925	COG0200	Binds to the 23S rRNA
YC6258_RS24930	COG1841	ribosomal large subunit assembly
YC6258_RS24935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YC6258_RS24940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YC6258_RS24945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YC6258_RS24950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YC6258_RS24955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YC6258_RS24960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YC6258_RS24965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YC6258_RS24970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YC6258_RS24975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YC6258_RS24980	COG0255	Belongs to the universal ribosomal protein uL29 family
YC6258_RS24985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YC6258_RS24990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YC6258_RS24995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YC6258_RS25000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YC6258_RS25005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YC6258_RS25010	COG0089	rRNA binding
YC6258_RS25015	COG0088	Forms part of the polypeptide exit tunnel
YC6258_RS25020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YC6258_RS25025	COG0051	transcription antitermination factor activity, RNA binding
YC6258_RS25035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YC6258_RS25040	COG0049	tRNA binding
YC6258_RS25045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YC6258_RS25050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YC6258_RS25055	COG0085	RNA polymerase activity
YC6258_RS25060	COG0222	ribosome binding
YC6258_RS25065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YC6258_RS25070	COG0081	regulation of translation
YC6258_RS25075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YC6258_RS25095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YC6258_RS25145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
YC6258_RS25150	COG0739	heme binding
YC6258_RS25160	COG0316	Belongs to the HesB IscA family
YC6258_RS25175	COG0038	chloride channel
YC6258_RS25180	COG1981	membrane
YC6258_RS25185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YC6258_RS25185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YC6258_RS25190	COG0246	Mannitol dehydrogenase
YC6258_RS25215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YC6258_RS25225	COG2840	Smr protein MutS2
YC6258_RS25230	COG2207	Transcriptional regulator
YC6258_RS25235	COG3724	N-succinylarginine dihydrolase activity
YC6258_RS25240	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS25245	COG3138	arginine N-succinyltransferase
YC6258_RS25255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YC6258_RS25280	COG1254	Belongs to the acylphosphatase family
YC6258_RS25295	COG4615	Cyclic peptide transporter
YC6258_RS25300	COG0493	'glutamate synthase
YC6258_RS25305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YC6258_RS25305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
YC6258_RS25305	COG1013	pyruvate-flavodoxin oxidoreductase activity
YC6258_RS25305	COG0674	pyruvate-flavodoxin oxidoreductase activity
YC6258_RS25310	COG2755	lipolytic protein G-D-S-L family
YC6258_RS25325	COG0281	malic enzyme
YC6258_RS25350	COG1858	cytochrome C peroxidase
YC6258_RS25375	COG0589	response to stress
YC6258_RS25385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS25395	COG3384	dioxygenase
YC6258_RS25400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YC6258_RS25405	COG1960	acyl-CoA dehydrogenase activity
YC6258_RS25425	COG3971	2-oxopent-4-enoate hydratase activity
YC6258_RS25440	COG0179	Fumarylacetoacetate (FAA) hydrolase
YC6258_RS25450	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS25460	COG2197	response regulator
YC6258_RS25465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YC6258_RS25490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YC6258_RS25505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS25525	COG1609	Transcriptional regulator
YC6258_RS25530	COG5297	Belongs to the glycosyl hydrolase family 6
YC6258_RS25535	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS25540	COG3122	Protein conserved in bacteria
YC6258_RS25545	COG0513	Belongs to the DEAD box helicase family
YC6258_RS25550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YC6258_RS25555	COG1307	EDD domain protein, DegV family
YC6258_RS25560	COG1079	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS25565	COG4603	Belongs to the binding-protein-dependent transport system permease family
YC6258_RS25570	COG3845	ABC transporter
YC6258_RS25575	COG1744	ABC transporter substrate-binding protein PnrA-like
YC6258_RS25585	COG0737	Belongs to the 5'-nucleotidase family
YC6258_RS25590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YC6258_RS25605	COG4104	PAAR repeat-containing protein
YC6258_RS25615	COG0248	Ppx GppA phosphatase
YC6258_RS25620	COG1490	D-aminoacyl-tRNA deacylase activity
YC6258_RS25650	COG5002	protein histidine kinase activity
YC6258_RS25650	COG3850	Histidine kinase
YC6258_RS25660	COG1217	gtp-binding protein TYPA
YC6258_RS25670	COG0494	nUDIX hydrolase
YC6258_RS25685	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
YC6258_RS25695	COG1011	Hydrolase
YC6258_RS25700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YC6258_RS25705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
YC6258_RS25710	COG2183	response to ionizing radiation
YC6258_RS25715	COG2918	glutathione biosynthetic process
YC6258_RS25730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
YC6258_RS25760	COG0488	(ABC) transporter
YC6258_RS25765	COG3290	protein histidine kinase activity
YC6258_RS25775	COG3265	gluconokinase activity
YC6258_RS25880	COG1063	alcohol dehydrogenase
YC6258_RS25900	COG0702	epimerase
YC6258_RS25905	COG1733	regulation of RNA biosynthetic process
YC6258_RS25985	COG2255	four-way junction helicase activity
YC6258_RS26000	COG0840	transmembrane signaling receptor activity
YC6258_RS26005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YC6258_RS26025	COG0352	thiamine-phosphate diphosphorylase activity
YC6258_RS26030	COG2207	Transcriptional regulator
YC6258_RS26115	COG2204	response regulator
YC6258_RS26130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS26145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YC6258_RS26155	COG3025	triphosphatase activity
YC6258_RS26160	COG3850	Histidine kinase
YC6258_RS26165	COG2197	response regulator
YC6258_RS26170	COG0303	'Molybdopterin
YC6258_RS26175	COG0205	6-phosphofructokinase activity
YC6258_RS26180	COG1683	Conserved Protein
YC6258_RS26255	COG2197	response regulator
YC6258_RS26260	COG4585	Histidine kinase
YC6258_RS26275	COG1136	(ABC) transporter
YC6258_RS26280	COG0577	efflux transmembrane transporter activity
YC6258_RS26280	COG1136	(ABC) transporter
YC6258_RS26295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YC6258_RS26310	COG1177	transmembrane transport
YC6258_RS26315	COG1176	ABC-type spermidine putrescine transport system, permease component I
YC6258_RS26320	COG3842	ATPase activity
YC6258_RS26335	COG0174	glutamine synthetase
YC6258_RS26340	COG0174	glutamine synthetase
YC6258_RS26345	COG0004	ammonium transporteR
YC6258_RS26365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YC6258_RS26370	COG1012	belongs to the aldehyde dehydrogenase family
YC6258_RS26380	COG1858	cytochrome C peroxidase
YC6258_RS26385	COG1858	cytochrome C peroxidase
YC6258_RS26395	COG0697	spore germination
YC6258_RS26400	COG1846	Transcriptional regulator
YC6258_RS26415	COG0784	Response regulator, receiver
YC6258_RS26420	COG4251	negative regulation of phosphorylation
YC6258_RS26425	COG0840	transmembrane signaling receptor activity
YC6258_RS26445	COG1271	oxidase subunit
YC6258_RS26450	COG1294	oxidase, subunit
YC6258_RS26460	COG4988	ABC transporter
YC6258_RS26465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YC6258_RS26470	COG0733	neurotransmitter:sodium symporter activity
YC6258_RS26490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YC6258_RS26610	COG0454	-acetyltransferase
YC6258_RS26610	COG0456	acetyltransferase
YC6258_RS26615	COG1051	belongs to the nudix hydrolase family
YC6258_RS26620	COG0039	L-malate dehydrogenase activity
YC6258_RS26625	COG1794	racemase activity, acting on amino acids and derivatives
YC6258_RS26705	COG3409	Peptidoglycan-binding domain 1 protein
YC6258_RS26715	COG1609	Transcriptional regulator
YC6258_RS26725	COG4608	Belongs to the ABC transporter superfamily
YC6258_RS26740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YC6258_RS26745	COG0601	transmembrane transport
YC6258_RS26750	COG0747	negative chemotaxis
YC6258_RS26785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
YC6258_RS26825	COG3507	Belongs to the glycosyl hydrolase 43 family
YC6258_RS26855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YC6258_RS26890	COG2165	general secretion pathway protein
YC6258_RS26895	COG3706	GGDEF domain
YC6258_RS26915	COG2205	protein histidine kinase activity
YC6258_RS26915	COG0784	Response regulator, receiver
YC6258_RS26940	COG0584	glycerophosphoryl diester phosphodiesterase
YC6258_RS26945	COG2214	Heat shock protein DnaJ domain protein
YC6258_RS26965	COG5001	Diguanylate cyclase
YC6258_RS26990	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
YC6258_RS26995	COG2203	Gaf domain
YC6258_RS26995	COG3706	GGDEF domain
YC6258_RS26995	COG4251	negative regulation of phosphorylation
YC6258_RS26995	COG5001	Diguanylate cyclase
YC6258_RS27005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
YC6258_RS27060	COG2340	Cysteine-rich secretory protein family
YC6258_RS27070	COG3209	COG3209 Rhs family protein
YC6258_RS27100	COG3047	cAMP biosynthetic process
YC6258_RS27100	COG2885	chlorophyll binding
YC6258_RS27115	COG3706	GGDEF domain
YC6258_RS27205	COG5001	Diguanylate cyclase
YC6258_RS27250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YC6258_RS27260	COG2205	protein histidine kinase activity
YC6258_RS27270	COG1278	Cold shock
YC6258_RS27280	COG3209	COG3209 Rhs family protein
YC6258_RS27285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
YC6258_RS27310	COG5520	Belongs to the glycosyl hydrolase 30 family
YC6258_RS27310	COG3291	Pkd domain containing protein
YC6258_RS27310	COG4447	cellulose binding
YC6258_RS27315	COG5002	protein histidine kinase activity
YC6258_RS27315	COG2205	protein histidine kinase activity
YC6258_RS27315	COG0784	Response regulator, receiver
YC6258_RS27355	COG0470	DNA polymerase III
YC6258_RS27370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YC6258_RS27395	COG1086	Polysaccharide biosynthesis protein
YC6258_RS27405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS27435	COG2977	Belongs to the P-Pant transferase superfamily
YC6258_RS27450	COG4221	oxidoreductase activity
YC6258_RS27450	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS27450	COG3321	synthase
YC6258_RS27450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS27460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS27460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YC6258_RS27460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YC6258_RS27460	COG1028	Short-chain dehydrogenase reductase Sdr
YC6258_RS27460	COG3321	synthase
YC6258_RS27490	COG2205	protein histidine kinase activity
YC6258_RS27500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YC6258_RS27500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YC6258_RS27505	COG2272	Belongs to the type-B carboxylesterase lipase family
YC6258_RS27530	COG3507	Belongs to the glycosyl hydrolase 43 family
YC6258_RS27560	COG0840	transmembrane signaling receptor activity
YC6258_RS27575	COG1309	transcriptional regulator
YC6258_RS27580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
YC6258_RS27590	COG0156	8-amino-7-oxononanoate synthase activity
YC6258_RS27595	COG2205	protein histidine kinase activity
YC6258_RS27595	COG0784	Response regulator, receiver
YC6258_RS27645	COG3300	MHYT domain
YC6258_RS27645	COG5001	Diguanylate cyclase
YC6258_RS27655	COG0300	oxidoreductase activity
YC6258_RS27655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YC6258_RS27655	COG3321	synthase
YC6258_RS27655	COG4221	oxidoreductase activity
YC6258_RS27680	COG2205	protein histidine kinase activity
YC6258_RS27700	COG1360	Flagellar Motor Protein
YC6258_RS27710	COG4969	Belongs to the N-Me-Phe pilin family
YC6258_RS27740	COG4733	cellulase activity
YC6258_RS27755	COG5001	Diguanylate cyclase
YC6258_RS27755	COG3300	MHYT domain
YC6258_RS27760	COG2989	Protein conserved in bacteria