locus-tag	class	description
HD_RS00005	COG0445	tRNA wobble uridine modification
HD_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
HD_RS00015	COG3312	ion transport
HD_RS00020	COG0356	it plays a direct role in the translocation of protons across the membrane
HD_RS00030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HD_RS00035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HD_RS00040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HD_RS00045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HD_RS00050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HD_RS00055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HD_RS00100	COG4974	Belongs to the 'phage' integrase family
HD_RS00105	COG0037	tRNA processing
HD_RS00115	COG2264	protein methyltransferase activity
HD_RS00135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HD_RS00140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HD_RS00145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HD_RS00150	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HD_RS00155	COG1053	succinate dehydrogenase
HD_RS00160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HD_RS00165	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HD_RS00170	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HD_RS00180	COG0019	diaminopimelate decarboxylase activity
HD_RS00195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HD_RS00200	COG0706	membrane insertase activity
HD_RS00205	COG2050	protein possibly involved in aromatic compounds catabolism
HD_RS00215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HD_RS00215	COG2885	chlorophyll binding
HD_RS00220	COG0204	Acyl-transferase
HD_RS00230	COG0825	malonyl-CoA metabolic process
HD_RS00240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HD_RS00265	COG1072	(Pantothenic acid kinase))
HD_RS00270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD_RS00285	COG0521	Mo-molybdopterin cofactor biosynthetic process
HD_RS00295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HD_RS00300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HD_RS00305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HD_RS00315	COG0783	Belongs to the Dps family
HD_RS00320	COG1289	transmembrane transporter activity
HD_RS00325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HD_RS00330	COG3062	negative regulation of establishment of protein localization
HD_RS00335	COG0243	molybdopterin cofactor binding
HD_RS00340	COG0437	4 iron, 4 sulfur cluster binding
HD_RS00345	COG0348	domain, Protein
HD_RS00350	COG3043	anaerobic respiration
HD_RS00355	COG3005	denitrification pathway
HD_RS00360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HD_RS00365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HD_RS00365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HD_RS00370	COG1304	FMN binding
HD_RS00375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HD_RS00380	COG2932	Transcriptional regulator
HD_RS00385	COG3423	Transcriptional regulator
HD_RS00395	COG2842	Transposition protein
HD_RS00460	COG4382	Mu-like prophage protein Gp16
HD_RS00465	COG5566	PFAM Mor transcription activator
HD_RS00470	COG3023	N-Acetylmuramoyl-L-alanine amidase
HD_RS00490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HD_RS00500	COG0640	Transcriptional regulator
HD_RS00510	COG4373	Mu-like prophage FluMu protein gp28
HD_RS00515	COG4383	Mu-like prophage protein gp29
HD_RS00535	COG4397	Mu-like prophage major head subunit gpT
HD_RS00545	COG4387	Mu-like prophage protein GP36
HD_RS00550	COG5003	unkown
HD_RS00615	COG3392	D12 class N6 adenine-specific DNA methyltransferase
HD_RS00645	COG0579	oxidoreductase
HD_RS00650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HD_RS00660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HD_RS00665	COG0494	nUDIX hydrolase
HD_RS00670	COG0730	response to heat
HD_RS00675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HD_RS00685	COG0180	Tryptophanyl-tRNA synthetase
HD_RS00690	COG3120	sequence-specific DNA binding
HD_RS00695	COG1067	ATP-dependent peptidase activity
HD_RS00700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HD_RS00710	COG4795	General secretion pathway protein
HD_RS00725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HD_RS00730	COG1025	Belongs to the peptidase M16 family
HD_RS00735	COG0484	heat shock protein binding
HD_RS00740	COG0443	Heat shock 70 kDa protein
HD_RS00745	COG3590	peptidase
HD_RS00765	COG1755	Isoprenylcysteine carboxyl methyltransferase
HD_RS00770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HD_RS00775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HD_RS00780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HD_RS00785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HD_RS00795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HD_RS00800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HD_RS00805	COG0697	spore germination
HD_RS00810	COG0561	phosphatase activity
HD_RS00815	COG1040	competence protein
HD_RS00820	COG2813	Specifically methylates the guanine in position
HD_RS00825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HD_RS00830	COG0456	acetyltransferase
HD_RS00835	COG0513	Belongs to the DEAD box helicase family
HD_RS00840	COG0259	pyridoxamine-phosphate oxidase activity
HD_RS00845	COG0747	negative chemotaxis
HD_RS00850	COG2835	tetraacyldisaccharide 4'-kinase activity
HD_RS00855	COG1663	tetraacyldisaccharide 4'-kinase activity
HD_RS00860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HD_RS00865	COG0740	serine-type endopeptidase activity
HD_RS00885	COG0488	(ABC) transporter
HD_RS00890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HD_RS00895	COG2190	(PTS) system
HD_RS00900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HD_RS00905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HD_RS00910	COG1178	ABC-type Fe3 transport system permease component
HD_RS00915	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HD_RS00920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HD_RS00925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HD_RS00930	COG0505	Belongs to the CarA family
HD_RS00935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HD_RS00940	COG0275	rRNA processing
HD_RS00945	COG3116	cell division
HD_RS00950	COG0768	penicillin binding
HD_RS00955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HD_RS00960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HD_RS00965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HD_RS00970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HD_RS00975	COG0772	Belongs to the SEDS family
HD_RS00985	COG0024	Methionine aminopeptidase
HD_RS00990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HD_RS01000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HD_RS01005	COG5007	Belongs to the BolA IbaG family
HD_RS01015	COG2854	intermembrane phospholipid transfer
HD_RS01020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HD_RS01025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HD_RS01030	COG1127	ABC transporter
HD_RS01035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HD_RS01040	COG1090	epimerase
HD_RS01045	COG1438	arginine binding
HD_RS01050	COG0039	L-malate dehydrogenase activity
HD_RS01055	COG3133	Outer membrane lipoprotein
HD_RS01060	COG3102	Protein conserved in bacteria
HD_RS01065	COG0018	arginyl-trna synthetase
HD_RS01070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HD_RS01075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HD_RS01080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HD_RS01085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HD_RS01090	COG0196	riboflavin kinase activity
HD_RS01105	COG0745	RESPONSE REGULATOR receiver
HD_RS01115	COG3539	Fimbrial protein
HD_RS01125	COG3188	usher protein
HD_RS01190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HD_RS01195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HD_RS01200	COG1217	gtp-binding protein TYPA
HD_RS01205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HD_RS01210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HD_RS01215	COG1561	YicC-like family, N-terminal region
HD_RS01220	COG0354	folic acid binding
HD_RS01225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HD_RS01230	COG2197	response regulator
HD_RS01235	COG0116	Belongs to the methyltransferase superfamily
HD_RS01235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HD_RS01240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HD_RS01245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HD_RS01275	COG0601	transmembrane transport
HD_RS01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HD_RS01285	COG0444	Belongs to the ABC transporter superfamily
HD_RS01290	COG4608	Belongs to the ABC transporter superfamily
HD_RS01295	COG2183	response to ionizing radiation
HD_RS01300	COG3063	Type IV pilus biogenesis stability protein PilW
HD_RS01305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HD_RS01325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HD_RS01335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HD_RS01340	COG0251	oxidation-reduction process
HD_RS01345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HD_RS01350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HD_RS01355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HD_RS01360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HD_RS01365	COG0848	biopolymer transport protein
HD_RS01370	COG0811	peptide transport
HD_RS01375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD_RS01380	COG3118	belongs to the thioredoxin family
HD_RS01385	COG0492	ferredoxin-NADP+ reductase activity
HD_RS01390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HD_RS01400	COG3030	protein affecting phage T7 exclusion by the F plasmid
HD_RS01405	COG0425	Belongs to the sulfur carrier protein TusA family
HD_RS01410	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HD_RS01415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HD_RS01425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HD_RS01430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HD_RS01435	COG0437	4 iron, 4 sulfur cluster binding
HD_RS01440	COG3301	Polysulphide reductase, NrfD
HD_RS01445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HD_RS01450	COG0501	Belongs to the peptidase M48B family
HD_RS01455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HD_RS01460	COG0084	hydrolase, TatD family'
HD_RS01465	COG1966	Carbon starvation protein
HD_RS01470	COG1666	GTP binding
HD_RS01480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HD_RS01485	COG2081	HI0933 family
HD_RS01490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HD_RS01495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HD_RS01505	COG0716	FMN binding
HD_RS01510	COG0735	belongs to the Fur family
HD_RS01515	COG3008	intermembrane lipid transfer
HD_RS01520	COG1854	S-ribosylhomocysteine lyase activity
HD_RS01525	COG2194	sulfuric ester hydrolase activity
HD_RS01530	COG0252	asparaginase activity
HD_RS01535	COG0504	CTP synthase activity
HD_RS01540	COG5413	integral membrane protein
HD_RS01550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HD_RS01555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HD_RS01560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HD_RS01560	COG0316	Belongs to the HesB IscA family
HD_RS01565	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HD_RS01570	COG1805	sodium ion transport
HD_RS01575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HD_RS01580	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HD_RS01585	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HD_RS01590	COG2871	sodium ion transport
HD_RS01595	COG1477	protein flavinylation
HD_RS01600	COG2991	Protein conserved in bacteria
HD_RS01605	COG1629	transport
HD_RS01610	COG0482	sulfurtransferase activity
HD_RS01615	COG2814	Major facilitator Superfamily
HD_RS01635	COG4657	Part of a membrane complex involved in electron transport
HD_RS01640	COG2878	Part of a membrane complex involved in electron transport
HD_RS01645	COG4656	Part of a membrane complex involved in electron transport
HD_RS01650	COG4658	electron transport chain
HD_RS01660	COG4660	Part of a membrane complex involved in electron transport
HD_RS01665	COG1560	Kdo2-lipid A biosynthetic process
HD_RS01675	COG0512	Glutamine amidotransferase of anthranilate synthase
HD_RS01680	COG1322	Protein conserved in bacteria
HD_RS01680	COG1322	Protein conserved in bacteria
HD_RS01695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HD_RS01700	COG2137	regulation of response to DNA damage stimulus
HD_RS01710	COG0551	DNA topoisomerase type I activity
HD_RS01715	COG0009	L-threonylcarbamoyladenylate synthase
HD_RS01720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HD_RS01740	COG2960	long-chain fatty acid transporting porin activity
HD_RS01745	COG0166	Belongs to the GPI family
HD_RS01750	COG0733	neurotransmitter:sodium symporter activity
HD_RS01755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HD_RS01760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HD_RS01765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HD_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HD_RS01775	COG4972	Pilus assembly protein
HD_RS01800	COG4796	Type ii and iii secretion system protein
HD_RS01805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HD_RS01810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HD_RS01815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HD_RS01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HD_RS01825	COG0483	inositol monophosphate 1-phosphatase activity
HD_RS01830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HD_RS01840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HD_RS01845	COG0859	PFAM glycosyl transferase family 9
HD_RS01850	COG0469	pyruvate kinase activity
HD_RS01855	COG2062	phosphohistidine phosphatase, SixA
HD_RS01860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HD_RS01865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HD_RS01870	COG1388	LysM domain
HD_RS01870	COG0860	N-Acetylmuramoyl-L-alanine amidase
HD_RS01875	COG0802	atpase or kinase
HD_RS01880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HD_RS01885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HD_RS01890	COG1519	Transferase
HD_RS01895	COG0826	peptidase U32
HD_RS01910	COG1115	amino acid carrier protein
HD_RS01915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HD_RS01920	COG0205	6-phosphofructokinase activity
HD_RS01925	COG1216	Glycosyl transferase, family 2
HD_RS01935	COG0564	pseudouridine synthase activity
HD_RS01940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HD_RS01945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HD_RS01950	COG3306	glycosyltransferase involved in LPS biosynthesis
HD_RS01965	COG0148	phosphopyruvate hydratase activity
HD_RS01970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HD_RS02020	COG4396	Host-nuclease inhibitor protein Gam
HD_RS02055	COG3561	AntA/AntB antirepressor
HD_RS02070	COG3023	N-Acetylmuramoyl-L-alanine amidase
HD_RS02110	COG4383	Mu-like prophage protein gp29
HD_RS02115	COG2369	cell adhesion
HD_RS02120	COG5005	Phage virion morphogenesis
HD_RS02130	COG4397	Mu-like prophage major head subunit gpT
HD_RS02205	COG3392	D12 class N6 adenine-specific DNA methyltransferase
HD_RS02210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HD_RS02215	COG1472	Belongs to the glycosyl hydrolase 3 family
HD_RS02220	COG3066	DNA modification
HD_RS02225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HD_RS02230	COG2937	Belongs to the GPAT DAPAT family
HD_RS02235	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HD_RS02245	COG0795	lipopolysaccharide-transporting ATPase activity
HD_RS02250	COG0795	lipopolysaccharide-transporting ATPase activity
HD_RS02255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HD_RS02260	COG0602	queuosine metabolic process
HD_RS02265	COG0720	synthase
HD_RS02270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HD_RS02285	COG1027	Aspartate ammonia-lyase
HD_RS02290	COG0542	response to heat
HD_RS02300	COG0531	amino acid
HD_RS02305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HD_RS02310	COG0084	hydrolase, TatD family'
HD_RS02315	COG0210	DNA helicase
HD_RS02320	COG3842	ATPase activity
HD_RS02325	COG1176	ABC-type spermidine putrescine transport system, permease component I
HD_RS02330	COG1177	transmembrane transport
HD_RS02335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HD_RS02340	COG0709	Synthesizes selenophosphate from selenide and ATP
HD_RS02360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HD_RS02365	COG1660	Displays ATPase and GTPase activities
HD_RS02375	COG1137	ATPase activity
HD_RS02380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HD_RS02385	COG3117	lipopolysaccharide transmembrane transporter activity
HD_RS02390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HD_RS02400	COG1704	LemA family
HD_RS02405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HD_RS02415	COG0217	transcriptional regulatory protein
HD_RS02420	COG0494	nUDIX hydrolase
HD_RS02425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HD_RS02430	COG0402	S-adenosylhomocysteine deaminase activity
HD_RS02435	COG4143	(ABC) transporter
HD_RS02440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HD_RS02445	COG0617	tRNA 3'-terminal CCA addition
HD_RS02450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HD_RS02460	COG2911	Protein conserved in bacteria
HD_RS02470	COG0346	lactoylglutathione lyase activity
HD_RS02475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HD_RS02480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HD_RS02490	COG0475	glutathione-regulated potassium exporter activity
HD_RS02490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HD_RS02495	COG1138	Cytochrome C-type biogenesis protein
HD_RS02500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD_RS02505	COG4235	cytochrome complex assembly
HD_RS02505	COG3088	subunit of a heme lyase
HD_RS02515	COG0748	coenzyme F420 binding
HD_RS02520	COG1169	isochorismate synthase
HD_RS02525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HD_RS02530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HD_RS02535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HD_RS02560	COG2995	paraquat-inducible protein a
HD_RS02565	COG2171	N-acyltransferase activity
HD_RS02575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HD_RS02580	COG0511	ligase activity, forming carbon-carbon bonds
HD_RS02585	COG0439	Biotin carboxylase
HD_RS02595	COG3084	Protein conserved in bacteria
HD_RS02600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HD_RS02605	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HD_RS02610	COG0742	ribosomal rna small subunit methyltransferase
HD_RS02615	COG1876	peptidase activity
HD_RS02620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HD_RS02625	COG1393	Belongs to the ArsC family
HD_RS02630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HD_RS02635	COG0564	pseudouridine synthase activity
HD_RS02640	COG4771	TonB-dependent receptor
HD_RS02645	COG0668	transmembrane transport
HD_RS02650	COG0814	amino acid
HD_RS02655	COG0688	phosphatidylethanolamine metabolic process
HD_RS02660	COG1555	photosystem II stabilization
HD_RS02665	COG3061	Opacity-associated protein A
HD_RS02665	COG3266	domain, Protein
HD_RS02675	COG0859	PFAM glycosyl transferase family 9
HD_RS02680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HD_RS02685	COG0049	tRNA binding
HD_RS02690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HD_RS02695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HD_RS02700	COG1045	serine acetyltransferase
HD_RS02705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HD_RS02710	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HD_RS02720	COG0544	peptidyl-prolyl cis-trans isomerase activity
HD_RS02725	COG1652	LysM domain
HD_RS02730	COG2927	DNA polymerase III (CHI subunit)
HD_RS02740	COG0525	valine-tRNA ligase activity
HD_RS02745	COG4145	pantothenate transmembrane transporter activity
HD_RS02750	COG3924	membrane
HD_RS02755	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HD_RS02760	COG2853	Lipoprotein
HD_RS02775	COG1720	tRNA m6t6A37 methyltransferase activity
HD_RS02780	COG1575	Belongs to the MenA family. Type 1 subfamily
HD_RS02785	COG0316	Belongs to the HesB IscA family
HD_RS02790	COG1083	cytidylyl-transferase
HD_RS02800	COG1088	dTDP-glucose 4,6-dehydratase activity
HD_RS02810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HD_RS02820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HD_RS02825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HD_RS02830	COG0557	exoribonuclease II activity
HD_RS02835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD_RS02840	COG1309	transcriptional regulator
HD_RS02845	COG0583	DNA-binding transcription factor activity
HD_RS02850	COG0678	peroxiredoxin activity
HD_RS02850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HD_RS02855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HD_RS02860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HD_RS02865	COG0142	geranyltranstransferase activity
HD_RS02870	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HD_RS02875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HD_RS02885	COG1114	Component of the transport system for branched-chain amino acids
HD_RS02890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HD_RS02900	COG0805	protein transport
HD_RS02905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HD_RS02910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HD_RS02915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HD_RS02925	COG2226	methyltransferase
HD_RS02930	COG0598	Magnesium transport protein CorA
HD_RS02940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HD_RS02945	COG3085	chromosome segregation
HD_RS02950	COG0076	glutamate decarboxylase activity
HD_RS02955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HD_RS02960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HD_RS02965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HD_RS02970	COG2003	Belongs to the UPF0758 family
HD_RS02975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HD_RS02980	COG0756	dUTP diphosphatase activity
HD_RS02985	COG1309	transcriptional regulator
HD_RS03000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HD_RS03005	COG1923	regulation of RNA biosynthetic process
HD_RS03010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HD_RS03015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HD_RS03025	COG1490	D-aminoacyl-tRNA deacylase activity
HD_RS03035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HD_RS03045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HD_RS03055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HD_RS03060	COG0594	ribonuclease P activity
HD_RS03065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HD_RS03070	COG4942	peptidase
HD_RS03070	COG1388	LysM domain
HD_RS03080	COG1238	metal cluster binding
HD_RS03085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HD_RS03095	COG0149	triose-phosphate isomerase activity
HD_RS03100	COG1482	cell wall glycoprotein biosynthetic process
HD_RS03105	COG3716	PTS system mannose fructose sorbose family IID component
HD_RS03110	COG3715	PTS system
HD_RS03115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD_RS03115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HD_RS03125	COG4536	flavin adenine dinucleotide binding
HD_RS03130	COG1399	metal-binding, possibly nucleic acid-binding protein
HD_RS03135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HD_RS03140	COG0416	fatty acid biosynthetic process
HD_RS03145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HD_RS03150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HD_RS03155	COG3171	Protein conserved in bacteria
HD_RS03160	COG0762	integral membrane protein
HD_RS03165	COG1872	DUF167
HD_RS03175	COG2824	Alkylphosphonate utilization operon protein PhnA
HD_RS03180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HD_RS03185	COG0511	ligase activity, forming carbon-carbon bonds
HD_RS03185	COG5016	pyruvate
HD_RS03190	COG3630	sodium ion export across plasma membrane
HD_RS03220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HD_RS03225	COG4133	protoheme IX ABC transporter activity
HD_RS03230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HD_RS03235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HD_RS03240	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HD_RS03245	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HD_RS03250	COG1138	Cytochrome C-type biogenesis protein
HD_RS03255	COG2391	methyltransferase activity
HD_RS03280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HD_RS03290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HD_RS03295	COG0792	nuclease activity
HD_RS03300	COG3107	peptidoglycan biosynthetic process
HD_RS03315	COG3101	peptidyl-lysine hydroxylation
HD_RS03320	COG4232	protein-disulfide reductase activity
HD_RS03330	COG1126	abc transporter atp-binding protein
HD_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD_RS03340	COG4215	(ABC) transporter
HD_RS03345	COG4160	amino acid transport
HD_RS03350	COG0497	DNA recombination
HD_RS03355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HD_RS03365	COG0849	cell division
HD_RS03375	COG1181	Belongs to the D-alanine--D-alanine ligase family
HD_RS03380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HD_RS03385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HD_RS03390	COG0563	adenylate kinase activity
HD_RS03395	COG2814	Major facilitator Superfamily
HD_RS03405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HD_RS03410	COG3115	cell septum assembly
HD_RS03420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HD_RS03425	COG2814	Major facilitator Superfamily
HD_RS03430	COG0363	glucosamine-6-phosphate deaminase activity
HD_RS03435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HD_RS03440	COG1218	3'(2'),5'-bisphosphate nucleotidase
HD_RS03445	COG0494	nUDIX hydrolase
HD_RS03450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HD_RS03455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HD_RS03460	COG0616	signal peptide processing
HD_RS03465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HD_RS03470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HD_RS03475	COG2032	superoxide dismutase activity
HD_RS03480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HD_RS03485	COG0592	DNA-directed DNA polymerase activity
HD_RS03490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HD_RS03495	COG2194	sulfuric ester hydrolase activity
HD_RS03500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HD_RS03515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HD_RS03520	COG4591	ABC-type transport system involved in lipoprotein release permease component
HD_RS03525	COG1136	(ABC) transporter
HD_RS03530	COG4591	ABC-type transport system involved in lipoprotein release permease component
HD_RS03535	COG4172	Belongs to the ABC transporter superfamily
HD_RS03540	COG0191	fructose-bisphosphate aldolase activity
HD_RS03545	COG0126	phosphoglycerate kinase activity
HD_RS03550	COG0471	metal ion transport
HD_RS03555	COG0471	metal ion transport
HD_RS03560	COG0187	DNA topoisomerase II activity
HD_RS03565	COG1605	Chorismate mutase
HD_RS03565	COG0077	Prephenate dehydratase
HD_RS03570	COG1252	NADH dehydrogenase
HD_RS03575	COG3091	SprT-like family
HD_RS03580	COG3719	Belongs to the RNase T2 family
HD_RS03585	COG0616	signal peptide processing
HD_RS03590	COG0778	Nitroreductase
HD_RS03595	COG0300	oxidoreductase activity
HD_RS03600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HD_RS03605	COG2244	polysaccharide biosynthetic process
HD_RS03610	COG3306	glycosyltransferase involved in LPS biosynthesis
HD_RS03620	COG1216	Glycosyl transferase, family 2
HD_RS03625	COG1216	Glycosyl transferase, family 2
HD_RS03630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD_RS03635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HD_RS03640	COG0813	purine-nucleoside phosphorylase activity
HD_RS03645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HD_RS03650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HD_RS03655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HD_RS03660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HD_RS03665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HD_RS03675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HD_RS03700	COG3021	interspecies interaction between organisms
HD_RS03790	COG1705	Flagellar rod assembly protein muramidase FlgJ
HD_RS03790	COG3951	Flagellar rod assembly protein muramidase FlgJ
HD_RS03880	COG2003	Belongs to the UPF0758 family
HD_RS03940	COG0629	single-stranded DNA binding
HD_RS03985	COG0305	Participates in initiation and elongation during chromosome replication
HD_RS04010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD_RS04015	COG0308	aminopeptidase N
HD_RS04020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HD_RS04025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HD_RS04030	COG0295	cytidine deaminase activity
HD_RS04035	COG2177	Part of the ABC transporter FtsEX involved in
HD_RS04040	COG2884	Cell division ATP-binding protein ftsE
HD_RS04045	COG0552	protein localization to endoplasmic reticulum
HD_RS04050	COG0742	ribosomal rna small subunit methyltransferase
HD_RS04055	COG3099	Belongs to the UPF0263 family
HD_RS04060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HD_RS04065	COG0339	signal peptide processing
HD_RS04070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HD_RS04075	COG1882	Formate acetyltransferase
HD_RS04080	COG2116	formate transmembrane transporter activity
HD_RS04085	COG1238	metal cluster binding
HD_RS04090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HD_RS04095	COG0012	GTP binding
HD_RS04100	COG0193	aminoacyl-tRNA hydrolase activity
HD_RS04110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HD_RS04120	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HD_RS04130	COG3068	Protein conserved in bacteria
HD_RS04140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HD_RS04150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HD_RS04160	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HD_RS04165	COG0793	Belongs to the peptidase S41A family
HD_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HD_RS04200	COG0577	efflux transmembrane transporter activity
HD_RS04200	COG1136	(ABC) transporter
HD_RS04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD_RS04220	COG0537	adenosine 5'-monophosphoramidase activity
HD_RS04225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HD_RS04230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HD_RS04235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HD_RS04240	COG1162	GTPase activity
HD_RS04245	COG0583	DNA-binding transcription factor activity
HD_RS04250	COG1011	Hydrolase
HD_RS04255	COG0583	DNA-binding transcription factor activity
HD_RS04265	COG0210	DNA helicase
HD_RS04270	COG0165	Argininosuccinate lyase
HD_RS04280	COG1426	Protein conserved in bacteria
HD_RS04285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HD_RS04290	COG0124	histidyl-tRNA synthetase
HD_RS04295	COG2976	Protein conserved in bacteria
HD_RS04300	COG3201	nicotinamide mononucleotide transporter
HD_RS04310	COG0360	Binds together with S18 to 16S ribosomal RNA
HD_RS04315	COG2965	DNA replication, synthesis of RNA primer
HD_RS04325	COG0359	binds to the 23S rRNA
HD_RS04330	COG2268	Band 7 protein
HD_RS04335	COG2226	methyltransferase
HD_RS04340	COG0009	L-threonylcarbamoyladenylate synthase
HD_RS04345	COG1187	pseudouridine synthase activity
HD_RS04350	COG0105	UTP biosynthetic process
HD_RS04355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HD_RS04355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HD_RS04360	COG1441	menaquinone biosynthetic process
HD_RS04365	COG1187	pseudouridine synthase activity
HD_RS04375	COG3381	protein complex oligomerization
HD_RS04380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HD_RS04390	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HD_RS04395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HD_RS04405	COG2707	UPF0756 membrane protein
HD_RS04410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HD_RS04415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HD_RS04420	COG0534	Mate efflux family protein
HD_RS04425	COG1074	ATP-dependent DNA helicase activity
HD_RS04430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HD_RS04440	COG1959	2 iron, 2 sulfur cluster binding
HD_RS04445	COG1104	cysteine desulfurase activity
HD_RS04450	COG0822	iron-sulfur transferase activity
HD_RS04460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HD_RS04470	COG0443	Heat shock 70 kDa protein
HD_RS04475	COG0633	Ferredoxin
HD_RS04480	COG2975	iron-sulfur cluster assembly
HD_RS04485	COG1442	glycosyl transferase family 8
HD_RS04490	COG0617	tRNA 3'-terminal CCA addition
HD_RS04495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HD_RS04500	COG0215	cysteine-tRNA ligase activity
HD_RS04520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HD_RS04535	COG3642	lipopolysaccharide core region biosynthetic process
HD_RS04540	COG0302	gtp cyclohydrolase
HD_RS04545	COG0101	tRNA pseudouridine synthase activity
HD_RS04550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HD_RS04555	COG1560	Kdo2-lipid A biosynthetic process
HD_RS04560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HD_RS04575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HD_RS04585	COG3058	Necessary for formate dehydrogenase activity
HD_RS04590	COG2864	formate dehydrogenase
HD_RS04600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HD_RS04605	COG0730	response to heat
HD_RS04610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HD_RS04620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HD_RS04630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HD_RS04635	COG1459	type II secretion system
HD_RS04645	COG0237	dephospho-CoA kinase activity
HD_RS04650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HD_RS04655	COG1466	dna polymerase III delta subunit
HD_RS04660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HD_RS04665	COG0495	leucyl-tRNA aminoacylation
HD_RS04670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HD_RS04675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HD_RS04680	COG3106	COG3106 Predicted ATPase
HD_RS04685	COG0564	pseudouridine synthase activity
HD_RS04690	COG3098	single-species biofilm formation
HD_RS04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD_RS04695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HD_RS04700	COG1760	l-serine dehydratase
HD_RS04705	COG0814	amino acid
HD_RS04710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HD_RS04720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HD_RS04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HD_RS04735	COG2271	Major facilitator Superfamily
HD_RS04755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HD_RS04760	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HD_RS04765	COG0247	lactate metabolic process
HD_RS04780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HD_RS04780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HD_RS04785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HD_RS04790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HD_RS04795	COG0517	IMP dehydrogenase activity
HD_RS04795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HD_RS04805	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HD_RS04810	COG0561	phosphatase activity
HD_RS04815	COG1595	DNA-templated transcription, initiation
HD_RS04820	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HD_RS04835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HD_RS04840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HD_RS04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HD_RS04850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HD_RS04855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HD_RS04855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HD_RS04860	COG1160	GTP binding
HD_RS04865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HD_RS04870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HD_RS04875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HD_RS04880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HD_RS04885	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HD_RS04900	COG0750	zinc metalloprotease
HD_RS04905	COG0575	Belongs to the CDS family
HD_RS04910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HD_RS04915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD_RS04920	COG0671	phosphoesterase, PA-phosphatase related
HD_RS04925	COG1534	Rna-binding protein
HD_RS04930	COG0463	Glycosyl transferase, family 2
HD_RS04935	COG0859	PFAM glycosyl transferase family 9
HD_RS04945	COG2990	Protein conserved in bacteria
HD_RS04950	COG0328	RNA-DNA hybrid ribonuclease activity
HD_RS04955	COG1286	toxin biosynthetic process
HD_RS04970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HD_RS04980	COG0251	oxidation-reduction process
HD_RS04985	COG1496	oxidoreductase activity
HD_RS05000	COG1556	Lactate utilization protein
HD_RS05005	COG1139	Iron-sulfur cluster binding protein
HD_RS05010	COG0247	lactate metabolic process
HD_RS05025	COG1757	Na H antiporter
HD_RS05030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HD_RS05035	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HD_RS05040	COG4166	transmembrane transport
HD_RS05045	COG4168	peptide transport system, permease
HD_RS05050	COG4171	peptide transport system, permease
HD_RS05055	COG4172	Belongs to the ABC transporter superfamily
HD_RS05060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HD_RS05060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HD_RS05065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HD_RS05070	COG0189	ligase activity
HD_RS05075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HD_RS05080	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HD_RS05085	COG3052	prosthetic group binding
HD_RS05090	COG2301	Belongs to the HpcH HpaI aldolase family
HD_RS05095	COG3051	citrate lyase alpha subunit
HD_RS05100	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HD_RS05100	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HD_RS05105	COG0471	metal ion transport
HD_RS05110	COG0280	phosphate acetyltransferase
HD_RS05110	COG0281	malic enzyme
HD_RS05115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HD_RS05125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HD_RS05130	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HD_RS05135	COG2333	competence protein COMEC
HD_RS05135	COG0658	competence protein
HD_RS05140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HD_RS05160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HD_RS05165	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HD_RS05170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HD_RS05175	COG2226	methyltransferase
HD_RS05180	COG0596	Alpha beta hydrolase
HD_RS05185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HD_RS05190	COG0318	PFAM AMP-dependent synthetase and ligase
HD_RS05200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HD_RS05205	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HD_RS05215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HD_RS05230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HD_RS05240	COG0629	single-stranded DNA binding
HD_RS05245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HD_RS05250	COG1199	ATP-dependent helicase activity
HD_RS05255	COG1380	Effector of murein hydrolase LrgA
HD_RS05260	COG1346	cytolysis
HD_RS05270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HD_RS05280	COG1792	Involved in formation and maintenance of cell shape
HD_RS05285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HD_RS05290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HD_RS05295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HD_RS05375	COG2949	membrane
HD_RS05380	COG5645	(Lipo)protein
HD_RS05385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HD_RS05400	COG0142	geranyltranstransferase activity
HD_RS05405	COG1722	exodeoxyribonuclease VII activity
HD_RS05410	COG1368	sulfuric ester hydrolase activity
HD_RS05430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HD_RS05435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HD_RS05440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HD_RS05445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HD_RS05450	COG2990	Protein conserved in bacteria
HD_RS05455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HD_RS05460	COG0567	Dehydrogenase, E1 component
HD_RS05465	COG1121	(ABC) transporter
HD_RS05470	COG0739	heme binding
HD_RS05475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HD_RS05480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HD_RS05485	COG0561	phosphatase activity
HD_RS05495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HD_RS05500	COG0393	Putative heavy-metal-binding
HD_RS05505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HD_RS05510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HD_RS05515	COG0539	negative regulation of cytoplasmic translation
HD_RS05520	COG0776	regulation of translation
HD_RS05525	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HD_RS05530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HD_RS05535	COG0284	orotidine-5'-phosphate decarboxylase activity
HD_RS05540	COG0023	Translation Initiation Factor
HD_RS05545	COG3787	Belongs to the UPF0306 family
HD_RS05555	COG3094	Invasion gene expression up-regulator, SirB
HD_RS05560	COG3028	Belongs to the UPF0307 family
HD_RS05565	COG0312	modulator of DNA gyrase
HD_RS05570	COG0288	reversible hydration of carbon dioxide
HD_RS05575	COG1278	Cold shock
HD_RS05585	COG0343	queuine tRNA-ribosyltransferase activity
HD_RS05590	COG4991	sh3 domain protein
HD_RS05595	COG0306	phosphate transporter
HD_RS05600	COG1392	Phosphate transport regulator
HD_RS05605	COG0305	Participates in initiation and elongation during chromosome replication
HD_RS05610	COG3100	YcgL domain-containing protein
HD_RS05615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HD_RS05620	COG0527	aspartate kinase activity
HD_RS05625	COG2926	Belongs to the UPF0265 family
HD_RS05630	COG0248	Ppx GppA phosphatase
HD_RS05635	COG2731	YhcH YjgK YiaL family protein
HD_RS05640	COG1737	Transcriptional regulator
HD_RS05645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HD_RS05650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HD_RS05655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HD_RS05655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HD_RS05660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HD_RS05665	COG1444	tRNA N-acetyltransferase activity
HD_RS05670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HD_RS05675	COG0314	molybdopterin synthase activity
HD_RS05680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HD_RS05685	COG0315	cyclic pyranopterin monophosphate synthase activity
HD_RS05690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HD_RS05695	COG3005	denitrification pathway
HD_RS05700	COG0243	molybdopterin cofactor binding
HD_RS05710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HD_RS05715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HD_RS05720	COG0741	lytic transglycosylase activity
HD_RS05730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HD_RS05735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HD_RS05745	COG1509	lysine 2,3-aminomutase activity
HD_RS05750	COG0017	Asparaginyl-tRNA synthetase
HD_RS05755	COG2925	Exonuclease
HD_RS05765	COG0613	PHP domain protein
HD_RS05770	COG0556	nucleotide-excision repair
HD_RS05780	COG0006	proline dipeptidase activity
HD_RS05785	COG1448	Aminotransferase
HD_RS05795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HD_RS05800	COG0625	glutathione transferase activity
HD_RS05805	COG2969	positive regulation of protein catabolic process
HD_RS05815	COG0589	response to stress
HD_RS05820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HD_RS05825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HD_RS05830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HD_RS05950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HD_RS05955	COG0280	phosphate acetyltransferase
HD_RS05955	COG0857	belongs to the CobB CobQ family
HD_RS05960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HD_RS05965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HD_RS05970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HD_RS05975	COG0195	Participates in both transcription termination and antitermination
HD_RS05980	COG0779	Required for maturation of 30S ribosomal subunits
HD_RS05990	COG0285	dihydrofolate synthase activity
HD_RS05995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HD_RS06000	COG3956	TIGRFAM MazG family protein
HD_RS06005	COG0745	RESPONSE REGULATOR receiver
HD_RS06010	COG2205	protein histidine kinase activity
HD_RS06020	COG3074	FtsZ-dependent cytokinesis
HD_RS06025	COG1435	thymidine kinase activity
HD_RS06030	COG1214	PFAM Peptidase M22, glycoprotease
HD_RS06035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HD_RS06040	COG1674	ftsk spoiiie
HD_RS06045	COG1522	sequence-specific DNA binding
HD_RS06050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HD_RS06055	COG1940	carbohydrate kinase activity
HD_RS06055	COG1846	Transcriptional regulator
HD_RS06060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HD_RS06065	COG0791	NLP P60 protein
HD_RS06070	COG0776	regulation of translation
HD_RS06075	COG0072	phenylalanine-tRNA ligase activity
HD_RS06080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HD_RS06085	COG0778	Nitroreductase
HD_RS06090	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HD_RS06110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HD_RS06115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HD_RS06120	COG3105	Protein conserved in bacteria
HD_RS06130	COG0814	amino acid
HD_RS06135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HD_RS06140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HD_RS06145	COG0517	IMP dehydrogenase activity
HD_RS06145	COG0516	GMP reductase activity
HD_RS06150	COG0519	Catalyzes the synthesis of GMP from XMP
HD_RS06150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HD_RS06160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HD_RS06170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HD_RS06175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HD_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HD_RS06185	COG3082	Protein of unknown function (DUF1414)
HD_RS06190	COG3083	sulfuric ester hydrolase activity
HD_RS06200	COG4382	Mu-like prophage protein Gp16
HD_RS06220	COG4396	Host-nuclease inhibitor protein Gam
HD_RS06230	COG3267	Type II secretory pathway component ExeA
HD_RS06230	COG3409	Peptidoglycan-binding domain 1 protein
HD_RS06325	COG4373	Mu-like prophage FluMu protein gp28
HD_RS06430	COG3392	D12 class N6 adenine-specific DNA methyltransferase
HD_RS06435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HD_RS06440	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HD_RS06445	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HD_RS06450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD_RS06455	COG1185	polyribonucleotide nucleotidyltransferase activity
HD_RS06460	COG4785	May be involved in cell division
HD_RS06465	COG0513	Belongs to the DEAD box helicase family
HD_RS06470	COG0590	tRNA wobble adenosine to inosine editing
HD_RS06475	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HD_RS06480	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HD_RS06490	COG0233	cytoplasmic translational termination
HD_RS06495	COG0528	UMP kinase activity
HD_RS06500	COG2194	sulfuric ester hydrolase activity
HD_RS06505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HD_RS06510	COG0052	Belongs to the universal ribosomal protein uS2 family
HD_RS06515	COG0433	COG0433 Predicted ATPase
HD_RS06525	COG1381	Involved in DNA repair and RecF pathway recombination
HD_RS06530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HD_RS06535	COG0571	ribonuclease III activity
HD_RS06540	COG0681	Belongs to the peptidase S26 family
HD_RS06545	COG0481	GTPase activity
HD_RS06595	COG1115	amino acid carrier protein
HD_RS06600	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HD_RS06605	COG3683	transport system, periplasmic component
HD_RS06620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HD_RS06625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HD_RS06630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HD_RS06635	COG0167	dihydroorotate dehydrogenase activity
HD_RS06640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HD_RS06645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HD_RS06650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HD_RS06655	COG1132	(ABC) transporter
HD_RS06660	COG1530	ribonuclease E activity
HD_RS06665	COG0500	methyltransferase
HD_RS06675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HD_RS06705	COG1609	Transcriptional regulator
HD_RS06710	COG0586	Pfam SNARE associated Golgi protein
HD_RS06715	COG0187	DNA topoisomerase II activity
HD_RS06725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HD_RS06730	COG1349	DNA-binding transcription factor activity
HD_RS06735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HD_RS06740	COG2915	High frequency lysogenization protein hflD homolog
HD_RS06745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HD_RS06750	COG4988	ABC transporter
HD_RS06755	COG2911	Protein conserved in bacteria
HD_RS06760	COG0729	surface antigen
HD_RS06770	COG4942	peptidase
HD_RS06775	COG0588	phosphoglycerate mutase activity
HD_RS06780	COG0572	uridine kinase
HD_RS06785	COG0717	Belongs to the dCTP deaminase family
HD_RS06790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HD_RS06795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HD_RS06800	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HD_RS06805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HD_RS06805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HD_RS06810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HD_RS06815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HD_RS06820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HD_RS06835	COG0444	Belongs to the ABC transporter superfamily
HD_RS06840	COG4608	Belongs to the ABC transporter superfamily
HD_RS06850	COG0697	spore germination
HD_RS06855	COG2840	Smr protein MutS2
HD_RS06860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HD_RS06865	COG2226	methyltransferase
HD_RS06870	COG2830	Protein of unknown function (DUF452)
HD_RS06875	COG0156	8-amino-7-oxononanoate synthase activity
HD_RS06880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HD_RS06935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HD_RS06950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HD_RS06960	COG3078	GTPase activator activity
HD_RS06965	COG0786	glutamate:sodium symporter activity
HD_RS06970	COG3112	Uncharacterised protein family (UPF0231)
HD_RS06975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HD_RS06980	COG2350	Protein conserved in bacteria
HD_RS06985	COG1607	acyl-coa hydrolase
HD_RS06990	COG2917	probably involved in intracellular septation
HD_RS07000	COG3092	negative regulation of chromosome organization
HD_RS07005	COG0037	tRNA processing
HD_RS07010	COG2056	Na+-H+ antiporter family
HD_RS07015	COG0708	Exodeoxyribonuclease III
HD_RS07025	COG3306	glycosyltransferase involved in LPS biosynthesis
HD_RS07030	COG0254	rRNA binding
HD_RS07035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HD_RS07050	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HD_RS07055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HD_RS07060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HD_RS07065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HD_RS07070	COG0489	protein tyrosine kinase activity
HD_RS07075	COG4166	transmembrane transport
HD_RS07080	COG2095	MarC family integral membrane protein
HD_RS07085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HD_RS07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HD_RS07095	COG3071	HemY protein
HD_RS07100	COG2959	enzyme of heme biosynthesis
HD_RS07110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HD_RS07115	COG0488	(ABC) transporter
HD_RS07120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD_RS07130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HD_RS07135	COG1862	Preprotein translocase
HD_RS07140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HD_RS07145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HD_RS07150	COG1528	Iron-storage protein
HD_RS07155	COG1528	Iron-storage protein
HD_RS07160	COG2252	PERMEase
HD_RS07165	COG2255	four-way junction helicase activity
HD_RS07170	COG0632	four-way junction helicase activity
HD_RS07175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HD_RS07180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HD_RS07185	COG3023	N-Acetylmuramoyl-L-alanine amidase
HD_RS07190	COG0564	pseudouridine synthase activity
HD_RS07195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HD_RS07200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HD_RS07205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HD_RS07210	COG0303	'Molybdopterin
HD_RS07215	COG0488	(ABC) transporter
HD_RS07220	COG3768	UPF0283 membrane protein
HD_RS07225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HD_RS07230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HD_RS07240	COG0823	Involved in the tonB-independent uptake of proteins
HD_RS07250	COG0848	biopolymer transport protein
HD_RS07255	COG0811	peptide transport
HD_RS07260	COG0824	Thioesterase
HD_RS07270	COG1294	oxidase, subunit
HD_RS07275	COG1271	oxidase subunit
HD_RS07285	COG0459	protein refolding
HD_RS07290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HD_RS07295	COG0494	nUDIX hydrolase
HD_RS07300	COG0653	protein targeting
HD_RS07320	COG0271	Belongs to the BolA IbaG family
HD_RS07325	COG3056	Lipoprotein
HD_RS07330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HD_RS07335	COG1678	Uncharacterized ACR, COG1678
HD_RS07340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HD_RS07345	COG1253	flavin adenine dinucleotide binding
HD_RS07355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HD_RS07360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HD_RS07365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HD_RS07370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HD_RS07375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HD_RS07380	COG0424	maF-like protein
HD_RS07385	COG0301	tRNA thio-modification
HD_RS07385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD_RS07390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HD_RS07395	COG0330	HflC and HflK could
HD_RS07400	COG0330	HflC and HflK could
HD_RS07405	COG3118	belongs to the thioredoxin family
HD_RS07415	COG0322	excinuclease ABC activity
HD_RS07420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HD_RS07425	COG0670	Belongs to the BI1 family
HD_RS07430	COG2920	part of a sulfur-relay system
HD_RS07440	COG1121	(ABC) transporter
HD_RS07445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HD_RS07450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HD_RS07455	COG1131	(ABC) transporter
HD_RS07460	COG0842	Transport permease protein
HD_RS07465	COG0725	ABC transporter, periplasmic molybdate-binding protein
HD_RS07470	COG4149	molybdate abc transporter
HD_RS07475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HD_RS07480	COG2867	negative regulation of translational initiation
HD_RS07485	COG2914	Belongs to the UPF0125 (RnfH) family
HD_RS07490	COG1538	Outer membrane efflux protein
HD_RS07495	COG0194	GDP metabolic process
HD_RS07500	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HD_RS07505	COG2195	Cleaves the N-terminal amino acid of tripeptides
HD_RS07565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HD_RS07575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HD_RS07580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HD_RS07590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HD_RS07595	COG0363	glucosamine-6-phosphate deaminase activity
HD_RS07605	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HD_RS07610	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HD_RS07625	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HD_RS07650	COG3623	hexulose-6-phosphate isomerase
HD_RS07655	COG0235	Class ii aldolase
HD_RS07670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HD_RS07675	COG0814	amino acid
HD_RS07680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HD_RS07685	COG0085	RNA polymerase activity
HD_RS07690	COG0222	ribosome binding
HD_RS07695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HD_RS07700	COG0081	regulation of translation
HD_RS07705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HD_RS07710	COG0250	Participates in transcription elongation, termination and antitermination
HD_RS07715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HD_RS07720	COG1297	OPT oligopeptide transporter protein
HD_RS07725	COG0758	DNA mediated transformation
HD_RS07730	COG0242	peptide deformylase activity
HD_RS07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HD_RS07745	COG3691	Protein conserved in bacteria
HD_RS07755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HD_RS07760	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HD_RS07765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HD_RS07770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HD_RS07775	COG2900	Belongs to the SlyX family
HD_RS07780	COG0545	Peptidyl-prolyl cis-trans isomerase
HD_RS07785	COG2964	Protein conserved in bacteria
HD_RS07790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HD_RS07795	COG2923	Belongs to the DsrF TusC family
HD_RS07800	COG2168	tRNA wobble position uridine thiolation
HD_RS07825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HD_RS07835	COG1522	sequence-specific DNA binding
HD_RS07840	COG2502	aspartate--ammonia ligase
HD_RS07850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HD_RS07855	COG1595	DNA-templated transcription, initiation
HD_RS07865	COG0442	prolyl-tRNA aminoacylation
HD_RS07875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HD_RS07880	COG1758	RNA polymerase activity
HD_RS07885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HD_RS07890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HD_RS07895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HD_RS07900	COG0254	rRNA binding
HD_RS07905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HD_RS07910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HD_RS07920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HD_RS07925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HD_RS07930	COG0470	DNA polymerase III
HD_RS07935	COG0084	hydrolase, TatD family'
HD_RS07945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HD_RS07950	COG2832	Protein of unknown function (DUF454)
HD_RS07955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HD_RS07965	COG0751	glycine-tRNA ligase activity
HD_RS07970	COG0752	glycyl-tRNA synthetase alpha subunit
HD_RS07975	COG2850	peptidyl-arginine hydroxylation
HD_RS07980	COG0335	large ribosomal subunit rRNA binding
HD_RS07985	COG0336	Belongs to the RNA methyltransferase TrmD family
HD_RS07990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HD_RS07995	COG0228	four-way junction DNA binding
HD_RS08000	COG0203	ribosomal protein L17
HD_RS08005	COG0202	RNA polymerase activity
HD_RS08010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HD_RS08015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HD_RS08020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HD_RS08025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HD_RS08030	COG0201	protein transport
HD_RS08035	COG0200	Binds to the 23S rRNA
HD_RS08040	COG1841	ribosomal large subunit assembly
HD_RS08045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HD_RS08050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HD_RS08055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HD_RS08060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HD_RS08065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HD_RS08070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HD_RS08075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HD_RS08090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HD_RS08095	COG0255	Belongs to the universal ribosomal protein uL29 family
HD_RS08100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HD_RS08105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HD_RS08110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HD_RS08115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HD_RS08120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HD_RS08125	COG0089	rRNA binding
HD_RS08130	COG0088	Forms part of the polypeptide exit tunnel
HD_RS08135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HD_RS08140	COG0051	transcription antitermination factor activity, RNA binding
HD_RS08150	COG0114	fumarate hydratase activity
HD_RS08155	COG0728	peptidoglycan biosynthetic process
HD_RS08160	COG0268	Binds directly to 16S ribosomal RNA
HD_RS08165	COG0569	domain protein
HD_RS08170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HD_RS08175	COG3276	selenocysteine insertion sequence binding
HD_RS08180	COG1921	L-seryl-tRNASec selenium transferase activity
HD_RS08190	COG0716	FMN binding
HD_RS08195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HD_RS08215	COG0741	lytic transglycosylase activity
HD_RS08220	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HD_RS08225	COG1194	a g-specific adenine glycosylase
HD_RS08230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HD_RS08235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HD_RS08250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HD_RS08255	COG0321	lipoyl(octanoyl) transferase activity
HD_RS08260	COG2921	Belongs to the UPF0250 family
HD_RS08265	COG1686	Belongs to the peptidase S11 family
HD_RS08270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HD_RS08275	COG0772	Belongs to the SEDS family
HD_RS08280	COG0768	penicillin binding
HD_RS08285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HD_RS08290	COG0799	negative regulation of ribosome biogenesis
HD_RS08295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HD_RS08300	COG4771	TonB-dependent receptor
HD_RS08300	COG1629	transport
HD_RS08305	COG1970	mechanosensitive ion channel activity
HD_RS08310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HD_RS08315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HD_RS08325	COG1126	abc transporter atp-binding protein
HD_RS08330	COG0765	amino acid transport
HD_RS08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain