locus-tag	class	description
A6045_RS00010	COG2853	Lipoprotein
A6045_RS00015	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6045_RS00020	COG3924	membrane
A6045_RS00025	COG4145	pantothenate transmembrane transporter activity
A6045_RS00030	COG0525	valine-tRNA ligase activity
A6045_RS00040	COG2927	DNA polymerase III (CHI subunit)
A6045_RS00045	COG1652	LysM domain
A6045_RS00050	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6045_RS00060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6045_RS00065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6045_RS00070	COG1045	serine acetyltransferase
A6045_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6045_RS00080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6045_RS00085	COG0049	tRNA binding
A6045_RS00090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6045_RS00095	COG0859	PFAM glycosyl transferase family 9
A6045_RS00105	COG3266	domain, Protein
A6045_RS00105	COG3061	Opacity-associated protein A
A6045_RS00110	COG1555	photosystem II stabilization
A6045_RS00115	COG0688	phosphatidylethanolamine metabolic process
A6045_RS00120	COG0814	amino acid
A6045_RS00125	COG0668	transmembrane transport
A6045_RS00130	COG4771	TonB-dependent receptor
A6045_RS00135	COG0564	pseudouridine synthase activity
A6045_RS00140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6045_RS00145	COG1393	Belongs to the ArsC family
A6045_RS00150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6045_RS00155	COG1876	peptidase activity
A6045_RS00160	COG0742	ribosomal rna small subunit methyltransferase
A6045_RS00165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6045_RS00170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6045_RS00175	COG3084	Protein conserved in bacteria
A6045_RS00185	COG0439	Biotin carboxylase
A6045_RS00190	COG0511	ligase activity, forming carbon-carbon bonds
A6045_RS00195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6045_RS00205	COG2171	N-acyltransferase activity
A6045_RS00210	COG2995	paraquat-inducible protein a
A6045_RS00235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6045_RS00240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6045_RS00245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6045_RS00250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6045_RS00255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6045_RS00260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6045_RS00270	COG0356	it plays a direct role in the translocation of protons across the membrane
A6045_RS00275	COG3312	ion transport
A6045_RS00280	COG0357	Ribosomal RNA small subunit methyltransferase G
A6045_RS00285	COG0445	tRNA wobble uridine modification
A6045_RS00295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6045_RS00300	COG0765	amino acid transport
A6045_RS00305	COG1126	abc transporter atp-binding protein
A6045_RS00315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6045_RS00320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6045_RS00325	COG1970	mechanosensitive ion channel activity
A6045_RS00330	COG1629	transport
A6045_RS00330	COG4771	TonB-dependent receptor
A6045_RS00335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6045_RS00340	COG0799	negative regulation of ribosome biogenesis
A6045_RS00345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6045_RS00350	COG0768	penicillin binding
A6045_RS00355	COG0772	Belongs to the SEDS family
A6045_RS00360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6045_RS00365	COG1686	Belongs to the peptidase S11 family
A6045_RS00370	COG2921	Belongs to the UPF0250 family
A6045_RS00375	COG0321	lipoyl(octanoyl) transferase activity
A6045_RS00380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6045_RS00395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6045_RS00400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6045_RS00405	COG1194	a g-specific adenine glycosylase
A6045_RS00410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6045_RS00415	COG0741	lytic transglycosylase activity
A6045_RS00435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6045_RS00440	COG0716	FMN binding
A6045_RS00450	COG1921	L-seryl-tRNASec selenium transferase activity
A6045_RS00455	COG3276	selenocysteine insertion sequence binding
A6045_RS00460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6045_RS00465	COG0569	domain protein
A6045_RS00470	COG0268	Binds directly to 16S ribosomal RNA
A6045_RS00475	COG0728	peptidoglycan biosynthetic process
A6045_RS00480	COG0114	fumarate hydratase activity
A6045_RS00490	COG0051	transcription antitermination factor activity, RNA binding
A6045_RS00495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6045_RS00500	COG0088	Forms part of the polypeptide exit tunnel
A6045_RS00505	COG0089	rRNA binding
A6045_RS00510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6045_RS00515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6045_RS00520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6045_RS00525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6045_RS00530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6045_RS00535	COG0255	Belongs to the universal ribosomal protein uL29 family
A6045_RS00540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6045_RS00550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6045_RS00555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6045_RS00560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6045_RS00565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6045_RS00570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6045_RS00575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6045_RS00580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6045_RS00585	COG1841	ribosomal large subunit assembly
A6045_RS00590	COG0200	Binds to the 23S rRNA
A6045_RS00595	COG0201	protein transport
A6045_RS00600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6045_RS00605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6045_RS00610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6045_RS00615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6045_RS00620	COG0202	RNA polymerase activity
A6045_RS00625	COG0203	ribosomal protein L17
A6045_RS00630	COG0228	four-way junction DNA binding
A6045_RS00635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6045_RS00640	COG0336	Belongs to the RNA methyltransferase TrmD family
A6045_RS00645	COG0335	large ribosomal subunit rRNA binding
A6045_RS00650	COG2850	peptidyl-arginine hydroxylation
A6045_RS00655	COG0752	glycyl-tRNA synthetase alpha subunit
A6045_RS00660	COG0751	glycine-tRNA ligase activity
A6045_RS00670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6045_RS00675	COG2832	Protein of unknown function (DUF454)
A6045_RS00680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6045_RS00690	COG0084	hydrolase, TatD family'
A6045_RS00695	COG0470	DNA polymerase III
A6045_RS00700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6045_RS00705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6045_RS00720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6045_RS00725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6045_RS00730	COG0254	rRNA binding
A6045_RS00735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6045_RS00740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6045_RS00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6045_RS00750	COG1758	RNA polymerase activity
A6045_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6045_RS00765	COG0442	prolyl-tRNA aminoacylation
A6045_RS00775	COG1595	DNA-templated transcription, initiation
A6045_RS00780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6045_RS00790	COG2502	aspartate--ammonia ligase
A6045_RS00795	COG1522	sequence-specific DNA binding
A6045_RS00805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6045_RS00845	COG4974	Belongs to the 'phage' integrase family
A6045_RS00850	COG0037	tRNA processing
A6045_RS00860	COG2264	protein methyltransferase activity
A6045_RS00880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6045_RS00885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6045_RS00890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6045_RS00895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6045_RS00900	COG1053	succinate dehydrogenase
A6045_RS00905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6045_RS00910	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6045_RS00915	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6045_RS00920	COG0019	diaminopimelate decarboxylase activity
A6045_RS00935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6045_RS00940	COG0706	membrane insertase activity
A6045_RS00945	COG2050	protein possibly involved in aromatic compounds catabolism
A6045_RS00955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6045_RS00955	COG2885	chlorophyll binding
A6045_RS00960	COG0204	Acyl-transferase
A6045_RS00970	COG0825	malonyl-CoA metabolic process
A6045_RS00980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6045_RS01005	COG1072	(Pantothenic acid kinase))
A6045_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6045_RS01025	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6045_RS01035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6045_RS01040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6045_RS01045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6045_RS01055	COG0783	Belongs to the Dps family
A6045_RS01060	COG1289	transmembrane transporter activity
A6045_RS01065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6045_RS01070	COG3062	negative regulation of establishment of protein localization
A6045_RS01075	COG0243	molybdopterin cofactor binding
A6045_RS01080	COG0437	4 iron, 4 sulfur cluster binding
A6045_RS01085	COG0348	domain, Protein
A6045_RS01090	COG3043	anaerobic respiration
A6045_RS01095	COG3005	denitrification pathway
A6045_RS01100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6045_RS01105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6045_RS01105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6045_RS01110	COG1304	FMN binding
A6045_RS01120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6045_RS01125	COG2932	Transcriptional regulator
A6045_RS01130	COG3423	Transcriptional regulator
A6045_RS01140	COG2842	Transposition protein
A6045_RS01200	COG4382	Mu-like prophage protein Gp16
A6045_RS01205	COG5566	PFAM Mor transcription activator
A6045_RS01210	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6045_RS01230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6045_RS01240	COG0640	Transcriptional regulator
A6045_RS01250	COG4373	Mu-like prophage FluMu protein gp28
A6045_RS01255	COG4383	Mu-like prophage protein gp29
A6045_RS01285	COG4387	Mu-like prophage protein GP36
A6045_RS01290	COG5003	unkown
A6045_RS01355	COG3392	D12 class N6 adenine-specific DNA methyltransferase
A6045_RS01385	COG0579	oxidoreductase
A6045_RS01390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6045_RS01400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6045_RS01405	COG0494	nUDIX hydrolase
A6045_RS01410	COG0730	response to heat
A6045_RS01415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6045_RS01425	COG0180	Tryptophanyl-tRNA synthetase
A6045_RS01430	COG3120	sequence-specific DNA binding
A6045_RS01435	COG1067	ATP-dependent peptidase activity
A6045_RS01440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6045_RS01450	COG4795	General secretion pathway protein
A6045_RS01465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6045_RS01470	COG1025	Belongs to the peptidase M16 family
A6045_RS01475	COG0484	heat shock protein binding
A6045_RS01480	COG0443	Heat shock 70 kDa protein
A6045_RS01485	COG3590	peptidase
A6045_RS01505	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6045_RS01510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6045_RS01515	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6045_RS01520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6045_RS01525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6045_RS01535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6045_RS01540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6045_RS01545	COG0697	spore germination
A6045_RS01550	COG0561	phosphatase activity
A6045_RS01555	COG1040	competence protein
A6045_RS01560	COG2813	Specifically methylates the guanine in position
A6045_RS01565	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A6045_RS01570	COG0456	acetyltransferase
A6045_RS01575	COG0513	Belongs to the DEAD box helicase family
A6045_RS01580	COG0259	pyridoxamine-phosphate oxidase activity
A6045_RS01585	COG0747	negative chemotaxis
A6045_RS01590	COG2835	tetraacyldisaccharide 4'-kinase activity
A6045_RS01595	COG1663	tetraacyldisaccharide 4'-kinase activity
A6045_RS01600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6045_RS01605	COG0740	serine-type endopeptidase activity
A6045_RS01630	COG0488	(ABC) transporter
A6045_RS01635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6045_RS01640	COG2190	(PTS) system
A6045_RS01645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6045_RS01650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6045_RS01655	COG1178	ABC-type Fe3 transport system permease component
A6045_RS01660	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6045_RS01665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6045_RS01670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6045_RS01675	COG0505	Belongs to the CarA family
A6045_RS01680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6045_RS01685	COG0275	rRNA processing
A6045_RS01690	COG3116	cell division
A6045_RS01695	COG0768	penicillin binding
A6045_RS01700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6045_RS01705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6045_RS01710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6045_RS01715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6045_RS01720	COG0772	Belongs to the SEDS family
A6045_RS01730	COG0024	Methionine aminopeptidase
A6045_RS01735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6045_RS01745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6045_RS01750	COG5007	Belongs to the BolA IbaG family
A6045_RS01760	COG2854	intermembrane phospholipid transfer
A6045_RS01765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6045_RS01770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6045_RS01775	COG1127	ABC transporter
A6045_RS01780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6045_RS01785	COG1090	epimerase
A6045_RS01790	COG1438	arginine binding
A6045_RS01795	COG0039	L-malate dehydrogenase activity
A6045_RS01800	COG3133	Outer membrane lipoprotein
A6045_RS01805	COG3102	Protein conserved in bacteria
A6045_RS01810	COG0018	arginyl-trna synthetase
A6045_RS01815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6045_RS01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6045_RS01825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6045_RS01830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6045_RS01835	COG0196	riboflavin kinase activity
A6045_RS01850	COG0745	RESPONSE REGULATOR receiver
A6045_RS01860	COG3539	Fimbrial protein
A6045_RS01870	COG3188	usher protein
A6045_RS01930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6045_RS01935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6045_RS01940	COG1217	gtp-binding protein TYPA
A6045_RS01945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6045_RS01950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6045_RS01955	COG1561	YicC-like family, N-terminal region
A6045_RS01960	COG0354	folic acid binding
A6045_RS01965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6045_RS01970	COG2197	response regulator
A6045_RS01975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6045_RS01975	COG0116	Belongs to the methyltransferase superfamily
A6045_RS01980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6045_RS01985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6045_RS02015	COG2168	tRNA wobble position uridine thiolation
A6045_RS02020	COG2923	Belongs to the DsrF TusC family
A6045_RS02025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6045_RS02030	COG2964	Protein conserved in bacteria
A6045_RS02035	COG0545	Peptidyl-prolyl cis-trans isomerase
A6045_RS02040	COG2900	Belongs to the SlyX family
A6045_RS02045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6045_RS02050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6045_RS02055	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A6045_RS02060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6045_RS02070	COG3691	Protein conserved in bacteria
A6045_RS02080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6045_RS02085	COG0242	peptide deformylase activity
A6045_RS02090	COG0758	DNA mediated transformation
A6045_RS02095	COG1297	OPT oligopeptide transporter protein
A6045_RS02100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6045_RS02105	COG0250	Participates in transcription elongation, termination and antitermination
A6045_RS02110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6045_RS02115	COG0081	regulation of translation
A6045_RS02120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6045_RS02125	COG0222	ribosome binding
A6045_RS02130	COG0085	RNA polymerase activity
A6045_RS02135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6045_RS02140	COG0814	amino acid
A6045_RS02160	COG0235	Class ii aldolase
A6045_RS02165	COG3623	hexulose-6-phosphate isomerase
A6045_RS02190	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6045_RS02205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6045_RS02210	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6045_RS02220	COG0363	glucosamine-6-phosphate deaminase activity
A6045_RS02225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6045_RS02235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6045_RS02240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6045_RS02250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6045_RS02315	COG0601	transmembrane transport
A6045_RS02320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6045_RS02325	COG0444	Belongs to the ABC transporter superfamily
A6045_RS02330	COG4608	Belongs to the ABC transporter superfamily
A6045_RS02335	COG2183	response to ionizing radiation
A6045_RS02340	COG3063	Type IV pilus biogenesis stability protein PilW
A6045_RS02345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6045_RS02365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6045_RS02375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6045_RS02380	COG0251	oxidation-reduction process
A6045_RS02385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6045_RS02390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6045_RS02395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6045_RS02400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6045_RS02405	COG0848	biopolymer transport protein
A6045_RS02410	COG0811	peptide transport
A6045_RS02415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6045_RS02420	COG3118	belongs to the thioredoxin family
A6045_RS02425	COG0492	ferredoxin-NADP+ reductase activity
A6045_RS02430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6045_RS02440	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6045_RS02445	COG0425	Belongs to the sulfur carrier protein TusA family
A6045_RS02450	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6045_RS02455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6045_RS02465	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6045_RS02470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6045_RS02475	COG0437	4 iron, 4 sulfur cluster binding
A6045_RS02480	COG3301	Polysulphide reductase, NrfD
A6045_RS02485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6045_RS02490	COG0501	Belongs to the peptidase M48B family
A6045_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6045_RS02500	COG0084	hydrolase, TatD family'
A6045_RS02505	COG1966	Carbon starvation protein
A6045_RS02510	COG1666	GTP binding
A6045_RS02520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6045_RS02525	COG2081	HI0933 family
A6045_RS02530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6045_RS02535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6045_RS02545	COG0716	FMN binding
A6045_RS02550	COG0735	belongs to the Fur family
A6045_RS02555	COG3008	intermembrane lipid transfer
A6045_RS02560	COG1854	S-ribosylhomocysteine lyase activity
A6045_RS02565	COG2194	sulfuric ester hydrolase activity
A6045_RS02570	COG0252	asparaginase activity
A6045_RS02575	COG0504	CTP synthase activity
A6045_RS02580	COG5413	integral membrane protein
A6045_RS02590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6045_RS02595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6045_RS02600	COG0316	Belongs to the HesB IscA family
A6045_RS02600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6045_RS02605	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6045_RS02610	COG1805	sodium ion transport
A6045_RS02615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6045_RS02620	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6045_RS02625	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6045_RS02630	COG2871	sodium ion transport
A6045_RS02635	COG1477	protein flavinylation
A6045_RS02640	COG2991	Protein conserved in bacteria
A6045_RS02645	COG1629	transport
A6045_RS02650	COG0482	sulfurtransferase activity
A6045_RS02655	COG2814	Major facilitator Superfamily
A6045_RS02675	COG4657	Part of a membrane complex involved in electron transport
A6045_RS02680	COG2878	Part of a membrane complex involved in electron transport
A6045_RS02685	COG4656	Part of a membrane complex involved in electron transport
A6045_RS02690	COG4658	electron transport chain
A6045_RS02700	COG4660	Part of a membrane complex involved in electron transport
A6045_RS02705	COG1560	Kdo2-lipid A biosynthetic process
A6045_RS02715	COG0512	Glutamine amidotransferase of anthranilate synthase
A6045_RS02720	COG1322	Protein conserved in bacteria
A6045_RS02720	COG1322	Protein conserved in bacteria
A6045_RS02735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6045_RS02740	COG2137	regulation of response to DNA damage stimulus
A6045_RS02750	COG0551	DNA topoisomerase type I activity
A6045_RS02755	COG0009	L-threonylcarbamoyladenylate synthase
A6045_RS02760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6045_RS02780	COG2960	long-chain fatty acid transporting porin activity
A6045_RS02785	COG0166	Belongs to the GPI family
A6045_RS02790	COG0733	neurotransmitter:sodium symporter activity
A6045_RS02795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6045_RS02800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6045_RS02805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6045_RS02810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6045_RS02835	COG4796	Type ii and iii secretion system protein
A6045_RS02840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6045_RS02845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6045_RS02850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6045_RS02855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6045_RS02860	COG0483	inositol monophosphate 1-phosphatase activity
A6045_RS02865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6045_RS02875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6045_RS02880	COG0859	PFAM glycosyl transferase family 9
A6045_RS02885	COG0469	pyruvate kinase activity
A6045_RS02890	COG2062	phosphohistidine phosphatase, SixA
A6045_RS02895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6045_RS02900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6045_RS02905	COG1388	LysM domain
A6045_RS02905	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6045_RS02910	COG0802	atpase or kinase
A6045_RS02915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6045_RS02920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6045_RS02925	COG1519	Transferase
A6045_RS02930	COG0826	peptidase U32
A6045_RS02945	COG1115	amino acid carrier protein
A6045_RS02950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6045_RS02955	COG0205	6-phosphofructokinase activity
A6045_RS02960	COG1216	Glycosyl transferase, family 2
A6045_RS02970	COG0564	pseudouridine synthase activity
A6045_RS02975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6045_RS02980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6045_RS02985	COG3306	glycosyltransferase involved in LPS biosynthesis
A6045_RS03000	COG0148	phosphopyruvate hydratase activity
A6045_RS03005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6045_RS03050	COG4396	Host-nuclease inhibitor protein Gam
A6045_RS03085	COG3561	AntA/AntB antirepressor
A6045_RS03100	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6045_RS03140	COG4383	Mu-like prophage protein gp29
A6045_RS03145	COG2369	cell adhesion
A6045_RS03150	COG5005	Phage virion morphogenesis
A6045_RS03160	COG4397	Mu-like prophage major head subunit gpT
A6045_RS03235	COG3392	D12 class N6 adenine-specific DNA methyltransferase
A6045_RS03240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6045_RS03245	COG1472	Belongs to the glycosyl hydrolase 3 family
A6045_RS03250	COG3066	DNA modification
A6045_RS03255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6045_RS03260	COG2937	Belongs to the GPAT DAPAT family
A6045_RS03265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6045_RS03275	COG0795	lipopolysaccharide-transporting ATPase activity
A6045_RS03280	COG0795	lipopolysaccharide-transporting ATPase activity
A6045_RS03285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6045_RS03290	COG0602	queuosine metabolic process
A6045_RS03295	COG0720	synthase
A6045_RS03300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6045_RS03315	COG1027	Aspartate ammonia-lyase
A6045_RS03320	COG0542	response to heat
A6045_RS03330	COG0531	amino acid
A6045_RS03335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6045_RS03340	COG0084	hydrolase, TatD family'
A6045_RS03345	COG0210	DNA helicase
A6045_RS03350	COG3842	ATPase activity
A6045_RS03355	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6045_RS03360	COG1177	transmembrane transport
A6045_RS03365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6045_RS03370	COG0709	Synthesizes selenophosphate from selenide and ATP
A6045_RS03390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6045_RS03395	COG1660	Displays ATPase and GTPase activities
A6045_RS03405	COG1137	ATPase activity
A6045_RS03410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6045_RS03415	COG3117	lipopolysaccharide transmembrane transporter activity
A6045_RS03420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A6045_RS03430	COG1704	LemA family
A6045_RS03435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6045_RS03445	COG0217	transcriptional regulatory protein
A6045_RS03450	COG0494	nUDIX hydrolase
A6045_RS03455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6045_RS03460	COG0402	S-adenosylhomocysteine deaminase activity
A6045_RS03465	COG4143	(ABC) transporter
A6045_RS03470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6045_RS03475	COG0617	tRNA 3'-terminal CCA addition
A6045_RS03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6045_RS03490	COG2911	Protein conserved in bacteria
A6045_RS03500	COG0346	lactoylglutathione lyase activity
A6045_RS03505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6045_RS03510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6045_RS03520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6045_RS03520	COG0475	glutathione-regulated potassium exporter activity
A6045_RS03525	COG1138	Cytochrome C-type biogenesis protein
A6045_RS03530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6045_RS03535	COG4235	cytochrome complex assembly
A6045_RS03535	COG3088	subunit of a heme lyase
A6045_RS03545	COG0748	coenzyme F420 binding
A6045_RS03550	COG1169	isochorismate synthase
A6045_RS03555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6045_RS03560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6045_RS03565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6045_RS03590	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6045_RS03595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6045_RS03600	COG0194	GDP metabolic process
A6045_RS03605	COG1538	Outer membrane efflux protein
A6045_RS03610	COG2914	Belongs to the UPF0125 (RnfH) family
A6045_RS03615	COG2867	negative regulation of translational initiation
A6045_RS03620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6045_RS03625	COG4149	molybdate abc transporter
A6045_RS03630	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6045_RS03635	COG0842	Transport permease protein
A6045_RS03640	COG1131	(ABC) transporter
A6045_RS03645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6045_RS03650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6045_RS03655	COG1121	(ABC) transporter
A6045_RS03665	COG2920	part of a sulfur-relay system
A6045_RS03670	COG0670	Belongs to the BI1 family
A6045_RS03675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6045_RS03680	COG0322	excinuclease ABC activity
A6045_RS03690	COG3118	belongs to the thioredoxin family
A6045_RS03695	COG0330	HflC and HflK could
A6045_RS03700	COG0330	HflC and HflK could
A6045_RS03705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6045_RS03710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6045_RS03710	COG0301	tRNA thio-modification
A6045_RS03715	COG0424	maF-like protein
A6045_RS03720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6045_RS03725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6045_RS03730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6045_RS03735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6045_RS03740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6045_RS03750	COG1253	flavin adenine dinucleotide binding
A6045_RS03755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6045_RS03760	COG1678	Uncharacterized ACR, COG1678
A6045_RS03765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6045_RS03770	COG3056	Lipoprotein
A6045_RS03775	COG0271	Belongs to the BolA IbaG family
A6045_RS03795	COG0653	protein targeting
A6045_RS03800	COG0494	nUDIX hydrolase
A6045_RS03805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6045_RS03810	COG0459	protein refolding
A6045_RS03820	COG1271	oxidase subunit
A6045_RS03825	COG1294	oxidase, subunit
A6045_RS03835	COG0824	Thioesterase
A6045_RS03840	COG0811	peptide transport
A6045_RS03845	COG0848	biopolymer transport protein
A6045_RS03850	COG3064	Membrane
A6045_RS03855	COG0823	Involved in the tonB-independent uptake of proteins
A6045_RS03865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6045_RS03870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6045_RS03875	COG3768	UPF0283 membrane protein
A6045_RS03880	COG0488	(ABC) transporter
A6045_RS03885	COG0303	'Molybdopterin
A6045_RS03890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6045_RS03895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6045_RS03900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6045_RS03905	COG0564	pseudouridine synthase activity
A6045_RS03910	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6045_RS03915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6045_RS03920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6045_RS03925	COG0632	four-way junction helicase activity
A6045_RS03930	COG2255	four-way junction helicase activity
A6045_RS03935	COG2252	PERMEase
A6045_RS03940	COG1528	Iron-storage protein
A6045_RS03945	COG1528	Iron-storage protein
A6045_RS03950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6045_RS03955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6045_RS03960	COG1862	Preprotein translocase
A6045_RS03965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6045_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6045_RS03980	COG0488	(ABC) transporter
A6045_RS03985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6045_RS03995	COG2959	enzyme of heme biosynthesis
A6045_RS04000	COG3071	HemY protein
A6045_RS04005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6045_RS04010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6045_RS04015	COG2095	MarC family integral membrane protein
A6045_RS04020	COG4166	transmembrane transport
A6045_RS04025	COG0489	protein tyrosine kinase activity
A6045_RS04030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6045_RS04035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6045_RS04040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6045_RS04045	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6045_RS04060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6045_RS04065	COG0254	rRNA binding
A6045_RS04070	COG3306	glycosyltransferase involved in LPS biosynthesis
A6045_RS04080	COG0708	Exodeoxyribonuclease III
A6045_RS04085	COG2056	Na+-H+ antiporter family
A6045_RS04090	COG0037	tRNA processing
A6045_RS04095	COG3092	negative regulation of chromosome organization
A6045_RS04105	COG2917	probably involved in intracellular septation
A6045_RS04110	COG1607	acyl-coa hydrolase
A6045_RS04115	COG2350	Protein conserved in bacteria
A6045_RS04120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6045_RS04125	COG3112	Uncharacterised protein family (UPF0231)
A6045_RS04130	COG0786	glutamate:sodium symporter activity
A6045_RS04135	COG3078	GTPase activator activity
A6045_RS04145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6045_RS04160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6045_RS04215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6045_RS04220	COG0156	8-amino-7-oxononanoate synthase activity
A6045_RS04225	COG2830	Protein of unknown function (DUF452)
A6045_RS04230	COG2226	methyltransferase
A6045_RS04235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6045_RS04240	COG2840	Smr protein MutS2
A6045_RS04245	COG0697	spore germination
A6045_RS04255	COG4608	Belongs to the ABC transporter superfamily
A6045_RS04260	COG0444	Belongs to the ABC transporter superfamily
A6045_RS04275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6045_RS04280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6045_RS04285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6045_RS04290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6045_RS04290	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6045_RS04295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6045_RS04300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6045_RS04305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6045_RS04310	COG0717	Belongs to the dCTP deaminase family
A6045_RS04315	COG0572	uridine kinase
A6045_RS04320	COG0588	phosphoglycerate mutase activity
A6045_RS04325	COG4942	peptidase
A6045_RS04335	COG0729	surface antigen
A6045_RS04340	COG2911	Protein conserved in bacteria
A6045_RS04345	COG4988	ABC transporter
A6045_RS04350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6045_RS04355	COG2915	High frequency lysogenization protein hflD homolog
A6045_RS04360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6045_RS04365	COG1349	DNA-binding transcription factor activity
A6045_RS04370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6045_RS04375	COG0187	DNA topoisomerase II activity
A6045_RS04380	COG0586	Pfam SNARE associated Golgi protein
A6045_RS04385	COG1609	Transcriptional regulator
A6045_RS04405	COG1570	exodeoxyribonuclease VII activity
A6045_RS04415	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6045_RS04425	COG0500	methyltransferase
A6045_RS04430	COG1530	ribonuclease E activity
A6045_RS04435	COG1132	(ABC) transporter
A6045_RS04440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6045_RS04445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6045_RS04450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6045_RS04455	COG0167	dihydroorotate dehydrogenase activity
A6045_RS04460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6045_RS04465	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6045_RS04470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6045_RS04490	COG3683	transport system, periplasmic component
A6045_RS04495	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A6045_RS04500	COG1115	amino acid carrier protein
A6045_RS04550	COG0481	GTPase activity
A6045_RS04555	COG0681	Belongs to the peptidase S26 family
A6045_RS04560	COG0571	ribonuclease III activity
A6045_RS04565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6045_RS04570	COG1381	Involved in DNA repair and RecF pathway recombination
A6045_RS04580	COG0433	COG0433 Predicted ATPase
A6045_RS04585	COG0052	Belongs to the universal ribosomal protein uS2 family
A6045_RS04590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6045_RS04595	COG2194	sulfuric ester hydrolase activity
A6045_RS04600	COG0528	UMP kinase activity
A6045_RS04605	COG0233	cytoplasmic translational termination
A6045_RS04615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A6045_RS04620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A6045_RS04625	COG0590	tRNA wobble adenosine to inosine editing
A6045_RS04630	COG0513	Belongs to the DEAD box helicase family
A6045_RS04635	COG4785	May be involved in cell division
A6045_RS04640	COG1185	polyribonucleotide nucleotidyltransferase activity
A6045_RS04645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6045_RS04650	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A6045_RS04655	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6045_RS04660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6045_RS04665	COG3392	D12 class N6 adenine-specific DNA methyltransferase
A6045_RS04770	COG4373	Mu-like prophage FluMu protein gp28
A6045_RS04860	COG3267	Type II secretory pathway component ExeA
A6045_RS04860	COG3409	Peptidoglycan-binding domain 1 protein
A6045_RS04870	COG4396	Host-nuclease inhibitor protein Gam
A6045_RS04890	COG4382	Mu-like prophage protein Gp16
A6045_RS04900	COG3083	sulfuric ester hydrolase activity
A6045_RS04905	COG3082	Protein of unknown function (DUF1414)
A6045_RS04910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6045_RS04915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6045_RS04920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6045_RS04930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6045_RS04940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6045_RS04940	COG0519	Catalyzes the synthesis of GMP from XMP
A6045_RS04945	COG0516	GMP reductase activity
A6045_RS04945	COG0517	IMP dehydrogenase activity
A6045_RS04950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6045_RS04955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6045_RS04970	COG3105	Protein conserved in bacteria
A6045_RS04975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6045_RS04980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6045_RS05000	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6045_RS05005	COG0778	Nitroreductase
A6045_RS05010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6045_RS05015	COG0072	phenylalanine-tRNA ligase activity
A6045_RS05020	COG0776	regulation of translation
A6045_RS05025	COG0791	NLP P60 protein
A6045_RS05030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6045_RS05035	COG1846	Transcriptional regulator
A6045_RS05035	COG1940	carbohydrate kinase activity
A6045_RS05040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6045_RS05045	COG1522	sequence-specific DNA binding
A6045_RS05050	COG1674	ftsk spoiiie
A6045_RS05055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6045_RS05060	COG1214	PFAM Peptidase M22, glycoprotease
A6045_RS05065	COG1435	thymidine kinase activity
A6045_RS05070	COG3074	FtsZ-dependent cytokinesis
A6045_RS05080	COG2205	protein histidine kinase activity
A6045_RS05085	COG0745	RESPONSE REGULATOR receiver
A6045_RS05090	COG3956	TIGRFAM MazG family protein
A6045_RS05095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6045_RS05100	COG0285	dihydrofolate synthase activity
A6045_RS05110	COG0779	Required for maturation of 30S ribosomal subunits
A6045_RS05115	COG0195	Participates in both transcription termination and antitermination
A6045_RS05120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6045_RS05125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6045_RS05130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6045_RS05135	COG0857	belongs to the CobB CobQ family
A6045_RS05135	COG0280	phosphate acetyltransferase
A6045_RS05140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6045_RS05290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6045_RS05295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6045_RS05300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6045_RS05305	COG0589	response to stress
A6045_RS05315	COG2969	positive regulation of protein catabolic process
A6045_RS05320	COG0625	glutathione transferase activity
A6045_RS05325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6045_RS05335	COG1448	Aminotransferase
A6045_RS05340	COG0006	proline dipeptidase activity
A6045_RS05350	COG0556	nucleotide-excision repair
A6045_RS05355	COG0613	PHP domain protein
A6045_RS05365	COG2925	Exonuclease
A6045_RS05370	COG0017	Asparaginyl-tRNA synthetase
A6045_RS05375	COG1509	lysine 2,3-aminomutase activity
A6045_RS05385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6045_RS05390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6045_RS05400	COG0741	lytic transglycosylase activity
A6045_RS05405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6045_RS05410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6045_RS05420	COG0243	molybdopterin cofactor binding
A6045_RS05425	COG3005	denitrification pathway
A6045_RS05430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6045_RS05435	COG0315	cyclic pyranopterin monophosphate synthase activity
A6045_RS05440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6045_RS05445	COG0314	molybdopterin synthase activity
A6045_RS05450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6045_RS05455	COG1444	tRNA N-acetyltransferase activity
A6045_RS05460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6045_RS05465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6045_RS05465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6045_RS05470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6045_RS05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6045_RS05480	COG1737	Transcriptional regulator
A6045_RS05485	COG2731	YhcH YjgK YiaL family protein
A6045_RS05490	COG0248	Ppx GppA phosphatase
A6045_RS05495	COG2926	Belongs to the UPF0265 family
A6045_RS05500	COG0527	aspartate kinase activity
A6045_RS05505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6045_RS05510	COG3100	YcgL domain-containing protein
A6045_RS05515	COG0305	Participates in initiation and elongation during chromosome replication
A6045_RS05520	COG1392	Phosphate transport regulator
A6045_RS05525	COG0306	phosphate transporter
A6045_RS05530	COG4991	sh3 domain protein
A6045_RS05535	COG0343	queuine tRNA-ribosyltransferase activity
A6045_RS05545	COG1278	Cold shock
A6045_RS05550	COG0288	reversible hydration of carbon dioxide
A6045_RS05555	COG0312	modulator of DNA gyrase
A6045_RS05560	COG3028	Belongs to the UPF0307 family
A6045_RS05565	COG3094	Invasion gene expression up-regulator, SirB
A6045_RS05575	COG3787	Belongs to the UPF0306 family
A6045_RS05580	COG0023	Translation Initiation Factor
A6045_RS05585	COG0284	orotidine-5'-phosphate decarboxylase activity
A6045_RS05590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6045_RS05595	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6045_RS05600	COG0776	regulation of translation
A6045_RS05605	COG0539	negative regulation of cytoplasmic translation
A6045_RS05610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6045_RS05615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6045_RS05620	COG0393	Putative heavy-metal-binding
A6045_RS05625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6045_RS05635	COG0561	phosphatase activity
A6045_RS05640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6045_RS05645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6045_RS05650	COG0739	heme binding
A6045_RS05655	COG1121	(ABC) transporter
A6045_RS05660	COG0567	Dehydrogenase, E1 component
A6045_RS05665	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6045_RS05670	COG2990	Protein conserved in bacteria
A6045_RS05675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6045_RS05680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6045_RS05685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6045_RS05690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6045_RS05710	COG1368	sulfuric ester hydrolase activity
A6045_RS05715	COG1722	exodeoxyribonuclease VII activity
A6045_RS05720	COG0142	geranyltranstransferase activity
A6045_RS05730	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6045_RS05735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6045_RS05740	COG5645	(Lipo)protein
A6045_RS05745	COG2949	membrane
A6045_RS05825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6045_RS05830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6045_RS05835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6045_RS05840	COG1792	Involved in formation and maintenance of cell shape
A6045_RS05850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6045_RS05860	COG1346	cytolysis
A6045_RS05865	COG1380	Effector of murein hydrolase LrgA
A6045_RS05870	COG1199	ATP-dependent helicase activity
A6045_RS05875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6045_RS05880	COG0629	single-stranded DNA binding
A6045_RS05890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6045_RS05910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6045_RS05920	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6045_RS05925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6045_RS05935	COG0318	PFAM AMP-dependent synthetase and ligase
A6045_RS05940	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6045_RS05945	COG0596	Alpha beta hydrolase
A6045_RS05950	COG2226	methyltransferase
A6045_RS05955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6045_RS05960	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A6045_RS05965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6045_RS05985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6045_RS05990	COG0658	competence protein
A6045_RS05990	COG2333	competence protein COMEC
A6045_RS05995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6045_RS06000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6045_RS06010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6045_RS06015	COG0280	phosphate acetyltransferase
A6045_RS06015	COG0281	malic enzyme
A6045_RS06020	COG0471	metal ion transport
A6045_RS06025	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A6045_RS06025	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A6045_RS06030	COG3051	citrate lyase alpha subunit
A6045_RS06035	COG2301	Belongs to the HpcH HpaI aldolase family
A6045_RS06040	COG3052	prosthetic group binding
A6045_RS06045	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A6045_RS06050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6045_RS06055	COG0189	ligase activity
A6045_RS06060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6045_RS06065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6045_RS06065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6045_RS06070	COG4172	Belongs to the ABC transporter superfamily
A6045_RS06075	COG4171	peptide transport system, permease
A6045_RS06080	COG4168	peptide transport system, permease
A6045_RS06085	COG4166	transmembrane transport
A6045_RS06090	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A6045_RS06095	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6045_RS06100	COG1757	Na H antiporter
A6045_RS06115	COG0247	lactate metabolic process
A6045_RS06120	COG1139	Iron-sulfur cluster binding protein
A6045_RS06125	COG1556	Lactate utilization protein
A6045_RS06140	COG1496	oxidoreductase activity
A6045_RS06145	COG0251	oxidation-reduction process
A6045_RS06155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6045_RS06170	COG1286	toxin biosynthetic process
A6045_RS06175	COG0328	RNA-DNA hybrid ribonuclease activity
A6045_RS06190	COG0859	PFAM glycosyl transferase family 9
A6045_RS06195	COG0463	Glycosyl transferase, family 2
A6045_RS06200	COG1534	Rna-binding protein
A6045_RS06205	COG0671	phosphoesterase, PA-phosphatase related
A6045_RS06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6045_RS06215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6045_RS06220	COG0575	Belongs to the CDS family
A6045_RS06225	COG0750	zinc metalloprotease
A6045_RS06240	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6045_RS06245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6045_RS06250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6045_RS06255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6045_RS06260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6045_RS06265	COG1160	GTP binding
A6045_RS06270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6045_RS06270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6045_RS06275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6045_RS06280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6045_RS06285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6045_RS06290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6045_RS06305	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6045_RS06310	COG1595	DNA-templated transcription, initiation
A6045_RS06315	COG0561	phosphatase activity
A6045_RS06320	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6045_RS06330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6045_RS06330	COG0517	IMP dehydrogenase activity
A6045_RS06335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6045_RS06340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6045_RS06345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6045_RS06345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6045_RS06360	COG0247	lactate metabolic process
A6045_RS06365	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A6045_RS06370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6045_RS06390	COG2271	Major facilitator Superfamily
A6045_RS06395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6045_RS06400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6045_RS06405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6045_RS06415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6045_RS06420	COG0814	amino acid
A6045_RS06425	COG1760	l-serine dehydratase
A6045_RS06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6045_RS06430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6045_RS06435	COG3098	single-species biofilm formation
A6045_RS06440	COG0564	pseudouridine synthase activity
A6045_RS06445	COG3106	COG3106 Predicted ATPase
A6045_RS06450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6045_RS06455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6045_RS06460	COG0495	leucyl-tRNA aminoacylation
A6045_RS06465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6045_RS06470	COG1466	dna polymerase III delta subunit
A6045_RS06475	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6045_RS06480	COG0237	dephospho-CoA kinase activity
A6045_RS06490	COG1459	type II secretion system
A6045_RS06495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6045_RS06505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6045_RS06515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6045_RS06520	COG0730	response to heat
A6045_RS06525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6045_RS06535	COG2864	formate dehydrogenase
A6045_RS06540	COG3058	Necessary for formate dehydrogenase activity
A6045_RS06550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6045_RS06565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6045_RS06570	COG1560	Kdo2-lipid A biosynthetic process
A6045_RS06575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6045_RS06580	COG0101	tRNA pseudouridine synthase activity
A6045_RS06585	COG0302	gtp cyclohydrolase
A6045_RS06590	COG3642	lipopolysaccharide core region biosynthetic process
A6045_RS06605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6045_RS06625	COG0215	cysteine-tRNA ligase activity
A6045_RS06630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6045_RS06635	COG0617	tRNA 3'-terminal CCA addition
A6045_RS06640	COG1442	glycosyl transferase family 8
A6045_RS06645	COG2975	iron-sulfur cluster assembly
A6045_RS06650	COG0633	Ferredoxin
A6045_RS06655	COG0443	Heat shock 70 kDa protein
A6045_RS06665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6045_RS06675	COG0822	iron-sulfur transferase activity
A6045_RS06680	COG1104	cysteine desulfurase activity
A6045_RS06685	COG1959	2 iron, 2 sulfur cluster binding
A6045_RS06695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6045_RS06700	COG1074	ATP-dependent DNA helicase activity
A6045_RS06705	COG0534	Mate efflux family protein
A6045_RS06710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6045_RS06715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6045_RS06720	COG2707	UPF0756 membrane protein
A6045_RS06730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6045_RS06735	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6045_RS06745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6045_RS06750	COG3381	protein complex oligomerization
A6045_RS06760	COG1187	pseudouridine synthase activity
A6045_RS06765	COG1441	menaquinone biosynthetic process
A6045_RS06770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6045_RS06770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6045_RS06775	COG0105	UTP biosynthetic process
A6045_RS06780	COG1187	pseudouridine synthase activity
A6045_RS06785	COG0009	L-threonylcarbamoyladenylate synthase
A6045_RS06790	COG2226	methyltransferase
A6045_RS06795	COG2268	Band 7 protein
A6045_RS06800	COG0359	binds to the 23S rRNA
A6045_RS06810	COG2965	DNA replication, synthesis of RNA primer
A6045_RS06815	COG0360	Binds together with S18 to 16S ribosomal RNA
A6045_RS06825	COG3201	nicotinamide mononucleotide transporter
A6045_RS06830	COG2976	Protein conserved in bacteria
A6045_RS06835	COG0124	histidyl-tRNA synthetase
A6045_RS06840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6045_RS06845	COG1426	Protein conserved in bacteria
A6045_RS06855	COG0165	Argininosuccinate lyase
A6045_RS06860	COG0210	DNA helicase
A6045_RS06870	COG0583	DNA-binding transcription factor activity
A6045_RS06875	COG1011	Hydrolase
A6045_RS06880	COG0583	DNA-binding transcription factor activity
A6045_RS06885	COG1162	GTPase activity
A6045_RS06890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6045_RS06895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6045_RS06900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6045_RS06905	COG0537	adenosine 5'-monophosphoramidase activity
A6045_RS06920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6045_RS06925	COG0577	efflux transmembrane transporter activity
A6045_RS06925	COG1136	(ABC) transporter
A6045_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6045_RS06960	COG0793	Belongs to the peptidase S41A family
A6045_RS06965	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6045_RS06975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6045_RS06985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6045_RS06995	COG3068	Protein conserved in bacteria
A6045_RS07005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6045_RS07015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6045_RS07025	COG0193	aminoacyl-tRNA hydrolase activity
A6045_RS07030	COG0012	GTP binding
A6045_RS07035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6045_RS07040	COG1238	metal cluster binding
A6045_RS07045	COG2116	formate transmembrane transporter activity
A6045_RS07050	COG1882	Formate acetyltransferase
A6045_RS07055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6045_RS07060	COG0339	signal peptide processing
A6045_RS07065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6045_RS07070	COG3099	Belongs to the UPF0263 family
A6045_RS07075	COG0742	ribosomal rna small subunit methyltransferase
A6045_RS07080	COG0552	protein localization to endoplasmic reticulum
A6045_RS07085	COG2884	Cell division ATP-binding protein ftsE
A6045_RS07090	COG2177	Part of the ABC transporter FtsEX involved in
A6045_RS07095	COG0295	cytidine deaminase activity
A6045_RS07100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6045_RS07105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6045_RS07110	COG0308	aminopeptidase N
A6045_RS07115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6045_RS07165	COG0629	single-stranded DNA binding
A6045_RS07195	COG2003	Belongs to the UPF0758 family
A6045_RS07210	COG3039	Transposase
A6045_RS07225	COG3039	Transposase
A6045_RS07240	COG0640	Transcriptional regulator
A6045_RS07475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6045_RS07495	COG0305	Participates in initiation and elongation during chromosome replication
A6045_RS07535	COG0629	single-stranded DNA binding
A6045_RS07600	COG2003	Belongs to the UPF0758 family
A6045_RS07685	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6045_RS07685	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6045_RS07775	COG3021	interspecies interaction between organisms
A6045_RS07795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6045_RS07805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6045_RS07810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6045_RS07815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6045_RS07820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6045_RS07825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6045_RS07830	COG0813	purine-nucleoside phosphorylase activity
A6045_RS07835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6045_RS07840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6045_RS07845	COG1216	Glycosyl transferase, family 2
A6045_RS07850	COG1216	Glycosyl transferase, family 2
A6045_RS07860	COG3306	glycosyltransferase involved in LPS biosynthesis
A6045_RS07865	COG2244	polysaccharide biosynthetic process
A6045_RS07870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6045_RS07875	COG0300	oxidoreductase activity
A6045_RS07880	COG0778	Nitroreductase
A6045_RS07885	COG0616	signal peptide processing
A6045_RS07890	COG3719	Belongs to the RNase T2 family
A6045_RS07895	COG3091	SprT-like family
A6045_RS07900	COG1252	NADH dehydrogenase
A6045_RS07905	COG1605	Chorismate mutase
A6045_RS07905	COG0077	Prephenate dehydratase
A6045_RS07910	COG0187	DNA topoisomerase II activity
A6045_RS07915	COG0471	metal ion transport
A6045_RS07920	COG0471	metal ion transport
A6045_RS07930	COG0191	fructose-bisphosphate aldolase activity
A6045_RS07935	COG4172	Belongs to the ABC transporter superfamily
A6045_RS07940	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6045_RS07945	COG1136	(ABC) transporter
A6045_RS07950	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6045_RS07955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6045_RS07970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6045_RS07975	COG2194	sulfuric ester hydrolase activity
A6045_RS07980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6045_RS07985	COG0592	DNA-directed DNA polymerase activity
A6045_RS07990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6045_RS07995	COG2032	superoxide dismutase activity
A6045_RS08000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6045_RS08005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6045_RS08010	COG0616	signal peptide processing
A6045_RS08015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6045_RS08020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6045_RS08025	COG0494	nUDIX hydrolase
A6045_RS08030	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6045_RS08035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6045_RS08040	COG0363	glucosamine-6-phosphate deaminase activity
A6045_RS08045	COG2814	Major facilitator Superfamily
A6045_RS08050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6045_RS08060	COG3115	cell septum assembly
A6045_RS08065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6045_RS08075	COG2814	Major facilitator Superfamily
A6045_RS08080	COG0563	adenylate kinase activity
A6045_RS08085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6045_RS08090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6045_RS08095	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6045_RS08105	COG0849	cell division
A6045_RS08115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6045_RS08120	COG0497	DNA recombination
A6045_RS08125	COG4160	amino acid transport
A6045_RS08130	COG4215	(ABC) transporter
A6045_RS08135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6045_RS08140	COG1126	abc transporter atp-binding protein
A6045_RS08150	COG4232	protein-disulfide reductase activity
A6045_RS08155	COG3101	peptidyl-lysine hydroxylation
A6045_RS08170	COG3107	peptidoglycan biosynthetic process
A6045_RS08175	COG0792	nuclease activity
A6045_RS08180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6045_RS08190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6045_RS08215	COG2391	methyltransferase activity
A6045_RS08220	COG1138	Cytochrome C-type biogenesis protein
A6045_RS08225	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6045_RS08230	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6045_RS08235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6045_RS08240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6045_RS08245	COG4133	protoheme IX ABC transporter activity
A6045_RS08280	COG3630	sodium ion export across plasma membrane
A6045_RS08290	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6045_RS08295	COG2824	Alkylphosphonate utilization operon protein PhnA
A6045_RS08305	COG1872	DUF167
A6045_RS08310	COG0762	integral membrane protein
A6045_RS08315	COG3171	Protein conserved in bacteria
A6045_RS08320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6045_RS08325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6045_RS08330	COG0416	fatty acid biosynthetic process
A6045_RS08335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6045_RS08340	COG1399	metal-binding, possibly nucleic acid-binding protein
A6045_RS08345	COG4536	flavin adenine dinucleotide binding
A6045_RS08355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6045_RS08355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6045_RS08360	COG3715	PTS system
A6045_RS08365	COG3716	PTS system mannose fructose sorbose family IID component
A6045_RS08370	COG1482	cell wall glycoprotein biosynthetic process
A6045_RS08375	COG0149	triose-phosphate isomerase activity
A6045_RS08385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6045_RS08390	COG1238	metal cluster binding
A6045_RS08400	COG4942	peptidase
A6045_RS08400	COG1388	LysM domain
A6045_RS08405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6045_RS08410	COG0594	ribonuclease P activity
A6045_RS08415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6045_RS08425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6045_RS08435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6045_RS08445	COG1490	D-aminoacyl-tRNA deacylase activity
A6045_RS08455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6045_RS08460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6045_RS08465	COG1923	regulation of RNA biosynthetic process
A6045_RS08470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6045_RS08485	COG1309	transcriptional regulator
A6045_RS08490	COG0756	dUTP diphosphatase activity
A6045_RS08495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6045_RS08500	COG2003	Belongs to the UPF0758 family
A6045_RS08505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6045_RS08510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6045_RS08515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6045_RS08520	COG0076	glutamate decarboxylase activity
A6045_RS08525	COG3085	chromosome segregation
A6045_RS08530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6045_RS08540	COG0598	Magnesium transport protein CorA
A6045_RS08545	COG2226	methyltransferase
A6045_RS08555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6045_RS08560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6045_RS08565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6045_RS08570	COG0805	protein transport
A6045_RS08580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6045_RS08585	COG1114	Component of the transport system for branched-chain amino acids
A6045_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
A6045_RS08595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6045_RS08600	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6045_RS08605	COG0142	geranyltranstransferase activity
A6045_RS08610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6045_RS08615	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6045_RS08620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6045_RS08620	COG0678	peroxiredoxin activity
A6045_RS08625	COG0583	DNA-binding transcription factor activity
A6045_RS08630	COG1309	transcriptional regulator
A6045_RS08635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6045_RS08640	COG0557	exoribonuclease II activity
A6045_RS08645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6045_RS08650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6045_RS08660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6045_RS08670	COG1088	dTDP-glucose 4,6-dehydratase activity
A6045_RS08680	COG1083	cytidylyl-transferase
A6045_RS08685	COG0316	Belongs to the HesB IscA family
A6045_RS08690	COG1575	Belongs to the MenA family. Type 1 subfamily
A6045_RS08695	COG1720	tRNA m6t6A37 methyltransferase activity