locus-tag	class	description
DV401_RS00005	COG0602	queuosine metabolic process
DV401_RS00015	COG0210	DNA helicase
DV401_RS00020	COG0601	transmembrane transport
DV401_RS00025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DV401_RS00030	COG0444	Belongs to the ABC transporter superfamily
DV401_RS00035	COG4608	Belongs to the ABC transporter superfamily
DV401_RS00040	COG1793	dna ligase
DV401_RS00050	COG1126	abc transporter atp-binding protein
DV401_RS00055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV401_RS00060	COG4215	(ABC) transporter
DV401_RS00065	COG4160	amino acid transport
DV401_RS00075	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DV401_RS00080	COG3091	SprT-like family
DV401_RS00090	COG0512	Glutamine amidotransferase of anthranilate synthase
DV401_RS00095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV401_RS00100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DV401_RS00110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DV401_RS00125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DV401_RS00125	COG2885	chlorophyll binding
DV401_RS00130	COG0277	FAD linked oxidase domain protein
DV401_RS00130	COG0247	lactate metabolic process
DV401_RS00135	COG2050	protein possibly involved in aromatic compounds catabolism
DV401_RS00145	COG3118	belongs to the thioredoxin family
DV401_RS00150	COG0492	ferredoxin-NADP+ reductase activity
DV401_RS00155	COG4988	ABC transporter
DV401_RS00160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DV401_RS00170	COG0602	queuosine metabolic process
DV401_RS00175	COG1823	symporter activity
DV401_RS00180	COG1280	lysine exporter protein (LysE YggA)
DV401_RS00185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DV401_RS00190	COG0312	modulator of DNA gyrase
DV401_RS00200	COG3117	lipopolysaccharide transmembrane transporter activity
DV401_RS00205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DV401_RS00210	COG1137	ATPase activity
DV401_RS00215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV401_RS00225	COG0077	Prephenate dehydratase
DV401_RS00225	COG1605	Chorismate mutase
DV401_RS00230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DV401_RS00235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DV401_RS00240	COG0849	cell division
DV401_RS00245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DV401_RS00255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DV401_RS00260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DV401_RS00265	COG0772	Belongs to the SEDS family
DV401_RS00270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DV401_RS00280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DV401_RS00290	COG0768	penicillin binding
DV401_RS00295	COG3116	cell division
DV401_RS00300	COG0275	rRNA processing
DV401_RS00310	COG1966	Carbon starvation protein
DV401_RS00320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DV401_RS00325	COG4166	transmembrane transport
DV401_RS00330	COG0601	transmembrane transport
DV401_RS00335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DV401_RS00340	COG0444	Belongs to the ABC transporter superfamily
DV401_RS00345	COG4608	Belongs to the ABC transporter superfamily
DV401_RS00350	COG2990	Protein conserved in bacteria
DV401_RS00360	COG0606	chelatase, subunit chli
DV401_RS00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV401_RS00380	COG1070	Carbohydrate kinase
DV401_RS00390	COG4213	ABC transporter substrate-binding protein
DV401_RS00395	COG1129	ABC transporter
DV401_RS00400	COG4214	carbohydrate transport
DV401_RS00405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DV401_RS00410	COG1757	Na H antiporter
DV401_RS00415	COG1609	Transcriptional regulator
DV401_RS00415	COG2207	Transcriptional regulator
DV401_RS00420	COG0859	PFAM glycosyl transferase family 9
DV401_RS00425	COG2814	Major facilitator Superfamily
DV401_RS00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DV401_RS00445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DV401_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV401_RS00475	COG1138	Cytochrome C-type biogenesis protein
DV401_RS00485	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV401_RS00490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV401_RS00495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV401_RS00505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DV401_RS00510	COG1127	ABC transporter
DV401_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DV401_RS00520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DV401_RS00525	COG2854	intermembrane phospholipid transfer
DV401_RS00530	COG3113	response to antibiotic
DV401_RS00535	COG5007	Belongs to the BolA IbaG family
DV401_RS00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV401_RS00550	COG0765	amino acid transport
DV401_RS00555	COG1126	abc transporter atp-binding protein
DV401_RS00560	COG3201	nicotinamide mononucleotide transporter
DV401_RS00575	COG1271	oxidase subunit
DV401_RS00580	COG1294	oxidase, subunit
DV401_RS00590	COG2363	Small membrane protein
DV401_RS00595	COG1643	Atp-dependent helicase
DV401_RS00600	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DV401_RS00605	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DV401_RS00610	COG0437	4 iron, 4 sulfur cluster binding
DV401_RS00615	COG3301	Polysulphide reductase, NrfD
DV401_RS00625	COG2194	sulfuric ester hydrolase activity
DV401_RS00630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DV401_RS00635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DV401_RS00655	COG3421	Type III restriction
DV401_RS00660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DV401_RS00665	COG4977	sequence-specific DNA binding
DV401_RS00665	COG1917	Cupin 2, conserved barrel domain protein
DV401_RS00670	COG1132	(ABC) transporter
DV401_RS00675	COG2608	mercury ion transmembrane transporter activity
DV401_RS00685	COG1305	Transglutaminase-like
DV401_RS00690	COG0243	molybdopterin cofactor binding
DV401_RS00695	COG0437	4 iron, 4 sulfur cluster binding
DV401_RS00700	COG3302	dmso reductase anchor subunit
DV401_RS00705	COG3381	protein complex oligomerization
DV401_RS00710	COG2221	Nitrite and sulphite reductase 4Fe-4S
DV401_RS00710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DV401_RS00745	COG0121	glutamine amidotransferase
DV401_RS00750	COG0762	integral membrane protein
DV401_RS00755	COG0598	Magnesium transport protein CorA
DV401_RS00765	COG0560	Phosphoserine phosphatase
DV401_RS00770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DV401_RS00780	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DV401_RS00785	COG1178	ABC-type Fe3 transport system permease component
DV401_RS00790	COG4143	(ABC) transporter
DV401_RS00850	COG2801	Transposase and inactivated derivatives
DV401_RS00865	COG2801	Transposase and inactivated derivatives
DV401_RS00880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DV401_RS00890	COG2610	gluconate transmembrane transporter activity
DV401_RS00895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DV401_RS00900	COG3622	Belongs to the hyi family
DV401_RS00905	COG0235	Class ii aldolase
DV401_RS00910	COG3395	kinase activity
DV401_RS00915	COG2084	Dehydrogenase
DV401_RS00920	COG1349	DNA-binding transcription factor activity
DV401_RS00925	COG1555	photosystem II stabilization
DV401_RS00935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DV401_RS00940	COG2194	sulfuric ester hydrolase activity
DV401_RS00945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DV401_RS00950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DV401_RS00955	COG0706	membrane insertase activity
DV401_RS00975	COG4783	chaperone-mediated protein folding
DV401_RS00985	COG4771	TonB-dependent receptor
DV401_RS00985	COG1629	transport
DV401_RS00990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DV401_RS00995	COG0592	DNA-directed DNA polymerase activity
DV401_RS01005	COG3468	outer membrane autotransporter barrel domain protein
DV401_RS01005	COG3266	domain, Protein
DV401_RS01015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DV401_RS01020	COG0473	3-isopropylmalate dehydrogenase activity
DV401_RS01030	COG0758	DNA mediated transformation
DV401_RS01035	COG3022	response to hydroperoxide
DV401_RS01060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DV401_RS01070	COG0697	spore germination
DV401_RS01075	COG4145	pantothenate transmembrane transporter activity
DV401_RS01080	COG3924	membrane
DV401_RS01085	COG4783	chaperone-mediated protein folding
DV401_RS01090	COG3266	domain, Protein
DV401_RS01095	COG0439	Biotin carboxylase
DV401_RS01100	COG0511	ligase activity, forming carbon-carbon bonds
DV401_RS01110	COG1441	menaquinone biosynthetic process
DV401_RS01115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DV401_RS01140	COG0728	peptidoglycan biosynthetic process
DV401_RS01145	COG0196	riboflavin kinase activity
DV401_RS01155	COG0537	adenosine 5'-monophosphoramidase activity
DV401_RS01160	COG5633	Lipoprotein
DV401_RS01165	COG1472	Belongs to the glycosyl hydrolase 3 family
DV401_RS01170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV401_RS01175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DV401_RS01195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DV401_RS01200	COG2003	Belongs to the UPF0758 family
DV401_RS01215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DV401_RS01220	COG0076	glutamate decarboxylase activity
DV401_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV401_RS01235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV401_RS01235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV401_RS01240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DV401_RS01245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DV401_RS01260	COG4795	General secretion pathway protein
DV401_RS01265	COG2165	general secretion pathway protein
DV401_RS01270	COG0483	inositol monophosphate 1-phosphatase activity
DV401_RS01275	COG1138	Cytochrome C-type biogenesis protein
DV401_RS01280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV401_RS01285	COG3088	subunit of a heme lyase
DV401_RS01285	COG4235	cytochrome complex assembly
DV401_RS01290	COG2081	HI0933 family
DV401_RS01300	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
DV401_RS01310	COG0754	glutathionylspermidine amidase activity
DV401_RS01315	COG0753	catalase activity
DV401_RS01320	COG0752	glycyl-tRNA synthetase alpha subunit
DV401_RS01325	COG4545	Glutaredoxin-related protein
DV401_RS01340	COG0751	glycine-tRNA ligase activity
DV401_RS01380	COG1466	dna polymerase III delta subunit
DV401_RS01385	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DV401_RS01395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DV401_RS01400	COG0575	Belongs to the CDS family
DV401_RS01405	COG0750	zinc metalloprotease
DV401_RS01415	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DV401_RS01435	COG2226	methyltransferase
DV401_RS01440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DV401_RS01440	COG0475	glutathione-regulated potassium exporter activity
DV401_RS01445	COG0494	nUDIX hydrolase
DV401_RS01450	COG0653	protein targeting
DV401_RS01460	COG4701	Protein of unknown function (DUF721)
DV401_RS01465	COG0590	tRNA wobble adenosine to inosine editing
DV401_RS01470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DV401_RS01480	COG0730	response to heat
DV401_RS01495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DV401_RS01500	COG1566	PFAM secretion protein HlyD family protein
DV401_RS01505	COG2814	Major facilitator Superfamily
DV401_RS01510	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DV401_RS01515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DV401_RS01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DV401_RS01525	COG1309	transcriptional regulator
DV401_RS01530	COG0513	Belongs to the DEAD box helicase family
DV401_RS01540	COG0237	dephospho-CoA kinase activity
DV401_RS01550	COG0151	Belongs to the GarS family
DV401_RS01555	COG0138	bifunctional purine biosynthesis protein purh
DV401_RS01560	COG2259	Doxx family
DV401_RS01565	COG4232	protein-disulfide reductase activity
DV401_RS01570	COG0745	RESPONSE REGULATOR receiver
DV401_RS01575	COG1115	amino acid carrier protein
DV401_RS01580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DV401_RS01585	COG0142	geranyltranstransferase activity
DV401_RS01600	COG0697	spore germination
DV401_RS01625	COG0174	glutamine synthetase
DV401_RS01635	COG1217	gtp-binding protein TYPA
DV401_RS01640	COG0259	pyridoxamine-phosphate oxidase activity
DV401_RS01645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DV401_RS01655	COG0557	exoribonuclease II activity
DV401_RS01660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV401_RS01665	COG0542	response to heat
DV401_RS01670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DV401_RS01685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DV401_RS01685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DV401_RS01705	COG0748	coenzyme F420 binding
DV401_RS01710	COG0747	negative chemotaxis
DV401_RS01715	COG2814	Major facilitator Superfamily
DV401_RS01720	COG1763	Mo-molybdopterin cofactor biosynthetic process
DV401_RS01730	COG3086	response to oxidative stress
DV401_RS01740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV401_RS01745	COG3085	chromosome segregation
DV401_RS01750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV401_RS01755	COG3084	Protein conserved in bacteria
DV401_RS01760	COG0746	molybdenum cofactor guanylyltransferase activity
DV401_RS01765	COG0402	S-adenosylhomocysteine deaminase activity
DV401_RS01770	COG3083	sulfuric ester hydrolase activity
DV401_RS01785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DV401_RS01790	COG0745	RESPONSE REGULATOR receiver
DV401_RS01805	COG1053	succinate dehydrogenase
DV401_RS01810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DV401_RS01815	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DV401_RS01820	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DV401_RS01825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DV401_RS01835	COG0741	lytic transglycosylase activity
DV401_RS01840	COG2350	Protein conserved in bacteria
DV401_RS01845	COG1607	acyl-coa hydrolase
DV401_RS01850	COG2917	probably involved in intracellular septation
DV401_RS01860	COG4211	Belongs to the binding-protein-dependent transport system permease family
DV401_RS01865	COG1129	ABC transporter
DV401_RS01870	COG1879	ABC-type sugar transport system periplasmic component
DV401_RS01875	COG1609	Transcriptional regulator
DV401_RS01880	COG1085	galactose-1-phosphate uridylyltransferase
DV401_RS01885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DV401_RS01890	COG2017	converts alpha-aldose to the beta-anomer
DV401_RS01900	COG0006	proline dipeptidase activity
DV401_RS01905	COG0589	response to stress
DV401_RS01920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DV401_RS01925	COG0165	Argininosuccinate lyase
DV401_RS01950	COG0730	response to heat
DV401_RS01975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DV401_RS01995	COG0201	protein transport
DV401_RS02080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DV401_RS02100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DV401_RS02105	COG0051	transcription antitermination factor activity, RNA binding
DV401_RS02110	COG0583	DNA-binding transcription factor activity
DV401_RS02115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DV401_RS02120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DV401_RS02125	COG2031	fatty acid transporter
DV401_RS02130	COG0183	Belongs to the thiolase family
DV401_RS02135	COG2177	Part of the ABC transporter FtsEX involved in
DV401_RS02140	COG2884	Cell division ATP-binding protein ftsE
DV401_RS02145	COG0552	protein localization to endoplasmic reticulum
DV401_RS02150	COG0742	ribosomal rna small subunit methyltransferase
DV401_RS02155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DV401_RS02160	COG3306	glycosyltransferase involved in LPS biosynthesis
DV401_RS02170	COG3172	ATPase kinase involved in NAD metabolism
DV401_RS02175	COG2129	metallophosphoesterase
DV401_RS02190	COG0741	lytic transglycosylase activity
DV401_RS02200	COG1194	a g-specific adenine glycosylase
DV401_RS02215	COG4942	peptidase
DV401_RS02220	COG2861	carbohydrate metabolic process
DV401_RS02225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DV401_RS02230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DV401_RS02245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DV401_RS02260	COG2937	Belongs to the GPAT DAPAT family
DV401_RS02265	COG1252	NADH dehydrogenase
DV401_RS02270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DV401_RS02275	COG0252	asparaginase activity
DV401_RS02280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DV401_RS02290	COG0702	epimerase
DV401_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DV401_RS02305	COG0587	DNA-directed DNA polymerase activity
DV401_RS02310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DV401_RS02320	COG0028	Belongs to the TPP enzyme family
DV401_RS02330	COG0733	neurotransmitter:sodium symporter activity
DV401_RS02345	COG0204	Acyl-transferase
DV401_RS02365	COG0514	ATP-dependent DNA helicase (RecQ)
DV401_RS02380	COG0019	diaminopimelate decarboxylase activity
DV401_RS02385	COG2197	response regulator
DV401_RS02420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DV401_RS02435	COG1464	Belongs to the NlpA lipoprotein family
DV401_RS02440	COG1349	DNA-binding transcription factor activity
DV401_RS02445	COG0705	Rhomboid family
DV401_RS02450	COG0564	pseudouridine synthase activity
DV401_RS02455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DV401_RS02460	COG1349	DNA-binding transcription factor activity
DV401_RS02465	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
DV401_RS02470	COG1070	Carbohydrate kinase
DV401_RS02480	COG0235	Class ii aldolase
DV401_RS02485	COG0738	Major facilitator superfamily
DV401_RS02505	COG0471	metal ion transport
DV401_RS02510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DV401_RS02515	COG1045	serine acetyltransferase
DV401_RS02525	COG3072	Adenylate cyclase
DV401_RS02530	COG2959	enzyme of heme biosynthesis
DV401_RS02535	COG3071	HemY protein
DV401_RS02580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DV401_RS02585	COG1739	Uncharacterized protein family UPF0029
DV401_RS02600	COG0251	oxidation-reduction process
DV401_RS02605	COG2853	Lipoprotein
DV401_RS02610	COG0250	Participates in transcription elongation, termination and antitermination
DV401_RS02615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DV401_RS02620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DV401_RS02640	COG3041	Addiction module toxin RelE StbE family
DV401_RS02645	COG3077	Addiction module antitoxin, RelB DinJ family
DV401_RS02655	COG3276	selenocysteine insertion sequence binding
DV401_RS02660	COG1921	L-seryl-tRNASec selenium transferase activity
DV401_RS02670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DV401_RS02675	COG0814	amino acid
DV401_RS02690	COG4942	peptidase
DV401_RS02690	COG1388	LysM domain
DV401_RS02700	COG1238	metal cluster binding
DV401_RS02705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DV401_RS02710	COG0585	pseudouridine synthase activity
DV401_RS02715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
DV401_RS02720	COG1047	Peptidyl-prolyl cis-trans
DV401_RS02725	COG0729	surface antigen
DV401_RS02730	COG2911	Protein conserved in bacteria
DV401_RS02735	COG0248	Ppx GppA phosphatase
DV401_RS02740	COG1187	pseudouridine synthase activity
DV401_RS02745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DV401_RS02755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DV401_RS02760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DV401_RS02765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DV401_RS02770	COG0584	glycerophosphoryl diester phosphodiesterase
DV401_RS02785	COG2271	Major facilitator Superfamily
DV401_RS02790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DV401_RS02795	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DV401_RS02800	COG0247	lactate metabolic process
DV401_RS02815	COG0583	DNA-binding transcription factor activity
DV401_RS02820	COG2962	Rard protein
DV401_RS02835	COG0456	acetyltransferase
DV401_RS02840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DV401_RS02845	COG2195	Cleaves the N-terminal amino acid of tripeptides
DV401_RS02850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DV401_RS02875	COG0716	FMN binding
DV401_RS02885	COG1494	fructose-1,6-bisphosphatase
DV401_RS02895	COG3550	peptidyl-serine autophosphorylation
DV401_RS02900	COG3550	peptidyl-serine autophosphorylation
DV401_RS02905	COG1132	(ABC) transporter
DV401_RS02910	COG4988	ABC transporter
DV401_RS02930	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
DV401_RS02935	COG3620	sequence-specific DNA binding
DV401_RS02940	COG0488	(ABC) transporter
DV401_RS02945	COG0551	DNA topoisomerase type I activity
DV401_RS02950	COG0009	L-threonylcarbamoyladenylate synthase
DV401_RS02960	COG2818	Glycosylase
DV401_RS02965	COG0463	Glycosyl transferase, family 2
DV401_RS02970	COG1519	Transferase
DV401_RS02975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DV401_RS02980	COG5645	(Lipo)protein
DV401_RS02985	COG0210	DNA helicase
DV401_RS02990	COG0583	DNA-binding transcription factor activity
DV401_RS02995	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV401_RS03000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DV401_RS03005	COG1285	pathogenesis
DV401_RS03010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DV401_RS03015	COG2267	carboxylic ester hydrolase activity
DV401_RS03040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DV401_RS03055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DV401_RS03065	COG0180	Tryptophanyl-tRNA synthetase
DV401_RS03070	COG3691	Protein conserved in bacteria
DV401_RS03075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DV401_RS03100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DV401_RS03115	COG0737	Belongs to the 5'-nucleotidase family
DV401_RS03120	COG1473	amidohydrolase
DV401_RS03125	COG3069	C4-dicarboxylate transmembrane transporter activity
DV401_RS03135	COG4771	TonB-dependent receptor
DV401_RS03135	COG1629	transport
DV401_RS03150	COG1288	antiporter activity
DV401_RS03155	COG0549	Belongs to the carbamate kinase family
DV401_RS03160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DV401_RS03165	COG0561	phosphatase activity
DV401_RS03185	COG3070	regulator of competence-specific genes
DV401_RS03225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DV401_RS03225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DV401_RS03230	COG0569	domain protein
DV401_RS03245	COG1595	DNA-templated transcription, initiation
DV401_RS03250	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
DV401_RS03255	COG3026	antisigma factor binding
DV401_RS03260	COG1072	(Pantothenic acid kinase))
DV401_RS03290	COG2168	tRNA wobble position uridine thiolation
DV401_RS03295	COG2923	Belongs to the DsrF TusC family
DV401_RS03300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DV401_RS03305	COG2964	Protein conserved in bacteria
DV401_RS03310	COG0545	Peptidyl-prolyl cis-trans isomerase
DV401_RS03320	COG0678	peroxiredoxin activity
DV401_RS03320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DV401_RS03325	COG0583	DNA-binding transcription factor activity
DV401_RS03330	COG1309	transcriptional regulator
DV401_RS03335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DV401_RS03340	COG2183	response to ionizing radiation
DV401_RS03345	COG0187	DNA topoisomerase II activity
DV401_RS03350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DV401_RS03365	COG1522	sequence-specific DNA binding
DV401_RS03370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DV401_RS03375	COG1297	OPT oligopeptide transporter protein
DV401_RS03385	COG1218	3'(2'),5'-bisphosphate nucleotidase
DV401_RS03390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DV401_RS03395	COG0363	glucosamine-6-phosphate deaminase activity
DV401_RS03405	COG1943	Transposase
DV401_RS03410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DV401_RS03420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DV401_RS03425	COG3306	glycosyltransferase involved in LPS biosynthesis
DV401_RS03475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DV401_RS03480	COG0831	urea catabolic process
DV401_RS03495	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DV401_RS03505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DV401_RS03515	COG1027	Aspartate ammonia-lyase
DV401_RS03520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DV401_RS03525	COG0358	DNA primase activity
DV401_RS03535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DV401_RS03540	COG1435	thymidine kinase activity
DV401_RS03545	COG0814	amino acid
DV401_RS03550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DV401_RS03555	COG3719	Belongs to the RNase T2 family
DV401_RS03565	COG0191	fructose-bisphosphate aldolase activity
DV401_RS03570	COG0859	PFAM glycosyl transferase family 9
DV401_RS03575	COG2364	Membrane
DV401_RS03580	COG1328	CTP reductase activity
DV401_RS03585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DV401_RS03590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DV401_RS03620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DV401_RS03625	COG0827	DNA restriction-modification system
DV401_RS03635	COG1275	C4-dicarboxylate transporter malic acid transport protein
DV401_RS03640	COG1720	tRNA m6t6A37 methyltransferase activity
DV401_RS03645	COG1575	Belongs to the MenA family. Type 1 subfamily
DV401_RS03660	COG1609	Transcriptional regulator
DV401_RS03665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DV401_RS03670	COG1879	ABC-type sugar transport system periplasmic component
DV401_RS03675	COG1172	Belongs to the binding-protein-dependent transport system permease family
DV401_RS03690	COG1322	Protein conserved in bacteria
DV401_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV401_RS03700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DV401_RS03715	COG3700	Belongs to the class B bacterial acid phosphatase family
DV401_RS03730	COG1238	metal cluster binding
DV401_RS03735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DV401_RS03750	COG3312	ion transport
DV401_RS03785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DV401_RS03795	COG0814	amino acid
DV401_RS03805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DV401_RS03805	COG0140	phosphoribosyl-ATP diphosphatase activity
DV401_RS03810	COG0107	imidazoleglycerol-phosphate synthase activity
DV401_RS03830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DV401_RS03835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DV401_RS03840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DV401_RS03845	COG1561	YicC-like family, N-terminal region
DV401_RS03850	COG0354	folic acid binding
DV401_RS03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DV401_RS03860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DV401_RS03865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV401_RS03870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DV401_RS03875	COG2990	Protein conserved in bacteria
DV401_RS03880	COG3956	TIGRFAM MazG family protein
DV401_RS03885	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DV401_RS03890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DV401_RS03895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DV401_RS03900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DV401_RS03910	COG0470	DNA polymerase III
DV401_RS03915	COG0084	hydrolase, TatD family'
DV401_RS03935	COG3309	Virulence-associated protein D
DV401_RS03945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV401_RS03945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV401_RS03950	COG1105	Belongs to the carbohydrate kinase PfkB family
DV401_RS03955	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DV401_RS03955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DV401_RS03955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DV401_RS04000	COG1802	Transcriptional regulator
DV401_RS04000	COG4626	Terminase
DV401_RS04060	COG0582	viral genome integration into host DNA
DV401_RS04070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DV401_RS04075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DV401_RS04085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DV401_RS04090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DV401_RS04095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DV401_RS04100	COG4972	Pilus assembly protein
DV401_RS04105	COG3166	PFAM Fimbrial assembly family protein
DV401_RS04120	COG4796	Type ii and iii secretion system protein
DV401_RS04125	COG1040	competence protein
DV401_RS04140	COG3068	Protein conserved in bacteria
DV401_RS04145	COG0776	regulation of translation
DV401_RS04150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DV401_RS04155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DV401_RS04170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DV401_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV401_RS04180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DV401_RS04185	COG0513	Belongs to the DEAD box helicase family
DV401_RS04195	COG4453	Protein conserved in bacteria
DV401_RS04200	COG0826	peptidase U32
DV401_RS04205	COG0477	Major facilitator Superfamily
DV401_RS04215	COG0351	phosphomethylpyrimidine kinase
DV401_RS04220	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DV401_RS04225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DV401_RS04230	COG1530	ribonuclease E activity
DV401_RS04235	COG0564	pseudouridine synthase activity
DV401_RS04240	COG1923	regulation of RNA biosynthetic process
DV401_RS04245	COG3283	Transcriptional regulator of aromatic amino acids metabolism
DV401_RS04250	COG0739	heme binding
DV401_RS04255	COG1121	(ABC) transporter
DV401_RS04260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV401_RS04265	COG0825	malonyl-CoA metabolic process
DV401_RS04270	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DV401_RS04275	COG0037	tRNA processing
DV401_RS04285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DV401_RS04290	COG2067	long-chain fatty acid transport protein
DV401_RS04295	COG3691	Protein conserved in bacteria
DV401_RS04300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DV401_RS04305	COG0494	nUDIX hydrolase
DV401_RS04315	COG2850	peptidyl-arginine hydroxylation
DV401_RS04330	COG0012	GTP binding
DV401_RS04335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DV401_RS04340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DV401_RS04345	COG0318	PFAM AMP-dependent synthetase and ligase
DV401_RS04350	COG3065	identical protein binding
DV401_RS04355	COG1214	PFAM Peptidase M22, glycoprotease
DV401_RS04360	COG1199	ATP-dependent helicase activity
DV401_RS04365	COG0824	Thioesterase
DV401_RS04370	COG0811	peptide transport
DV401_RS04375	COG0848	biopolymer transport protein
DV401_RS04380	COG3064	Membrane
DV401_RS04390	COG2885	chlorophyll binding
DV401_RS04405	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DV401_RS04410	COG1959	2 iron, 2 sulfur cluster binding
DV401_RS04420	COG0822	iron-sulfur transferase activity
DV401_RS04425	COG0316	Belongs to the HesB IscA family
DV401_RS04430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DV401_RS04440	COG0443	Heat shock 70 kDa protein
DV401_RS04445	COG0633	Ferredoxin
DV401_RS04450	COG2975	iron-sulfur cluster assembly
DV401_RS04455	COG2976	Protein conserved in bacteria
DV401_RS04460	COG0124	histidyl-tRNA synthetase
DV401_RS04470	COG1426	Protein conserved in bacteria
DV401_RS04475	COG3063	Type IV pilus biogenesis stability protein PilW
DV401_RS04485	COG1686	Belongs to the peptidase S11 family
DV401_RS04495	COG1121	(ABC) transporter
DV401_RS04500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV401_RS04505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV401_RS04510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DV401_RS04515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DV401_RS04520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DV401_RS04525	COG1116	anion transmembrane transporter activity
DV401_RS04535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DV401_RS04540	COG2814	Major facilitator Superfamily
DV401_RS04550	COG3005	denitrification pathway
DV401_RS04555	COG3043	anaerobic respiration
DV401_RS04560	COG0348	domain, Protein
DV401_RS04565	COG0437	4 iron, 4 sulfur cluster binding
DV401_RS04575	COG3062	negative regulation of establishment of protein localization
DV401_RS04580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DV401_RS04585	COG3171	Protein conserved in bacteria
DV401_RS04590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DV401_RS04595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DV401_RS04600	COG0628	permease
DV401_RS04605	COG0347	Belongs to the P(II) protein family
DV401_RS04610	COG0521	Mo-molybdopterin cofactor biosynthetic process
DV401_RS04615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DV401_RS04620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV401_RS04625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV401_RS04630	COG1381	Involved in DNA repair and RecF pathway recombination
DV401_RS04640	COG3061	Opacity-associated protein A
DV401_RS04640	COG3266	domain, Protein
DV401_RS04645	COG1509	lysine 2,3-aminomutase activity
DV401_RS04665	COG2056	Na+-H+ antiporter family
DV401_RS04670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DV401_RS04675	COG0346	lactoylglutathione lyase activity
DV401_RS04685	COG1755	Isoprenylcysteine carboxyl methyltransferase
DV401_RS04695	COG0494	nUDIX hydrolase
DV401_RS04725	COG4974	Belongs to the 'phage' integrase family
DV401_RS04730	COG2814	Major facilitator Superfamily
DV401_RS04735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DV401_RS04755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DV401_RS04760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DV401_RS04765	COG4535	Mg2 and Co2 transporter CorC
DV401_RS04770	COG3023	N-Acetylmuramoyl-L-alanine amidase
DV401_RS04775	COG4969	Belongs to the N-Me-Phe pilin family
DV401_RS04780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DV401_RS04785	COG1459	type II secretion system
DV401_RS04790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DV401_RS04795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DV401_RS04805	COG0789	Transcriptional regulator
DV401_RS04810	COG2608	mercury ion transmembrane transporter activity
DV401_RS04815	COG2217	Heavy metal translocating P-type atpase
DV401_RS04820	COG0814	amino acid
DV401_RS04825	COG1760	l-serine dehydratase
DV401_RS04830	COG0814	amino acid
DV401_RS04835	COG0436	Aminotransferase
DV401_RS04845	COG1169	isochorismate synthase
DV401_RS04855	COG2267	carboxylic ester hydrolase activity
DV401_RS04860	COG0477	Major facilitator Superfamily
DV401_RS04865	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DV401_RS04870	COG2258	MOSC domain
DV401_RS04885	COG1368	sulfuric ester hydrolase activity
DV401_RS04910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DV401_RS04920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DV401_RS04930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DV401_RS04940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DV401_RS04945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DV401_RS04950	COG3850	Histidine kinase
DV401_RS04960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DV401_RS04980	COG0859	PFAM glycosyl transferase family 9
DV401_RS04990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DV401_RS04995	COG1442	glycosyl transferase family 8
DV401_RS05005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DV401_RS05010	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DV401_RS05015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DV401_RS05020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DV401_RS05025	COG0811	peptide transport
DV401_RS05030	COG0848	biopolymer transport protein
DV401_RS05035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DV401_RS05040	COG0629	single-stranded DNA binding
DV401_RS05045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DV401_RS05060	COG2731	YhcH YjgK YiaL family protein
DV401_RS05075	COG4785	May be involved in cell division
DV401_RS05080	COG0513	Belongs to the DEAD box helicase family
DV401_RS05085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DV401_RS05095	COG3036	rescue of stalled ribosome
DV401_RS05100	COG1393	Belongs to the ArsC family
DV401_RS05110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV401_RS05115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV401_RS05120	COG1862	Preprotein translocase
DV401_RS05125	COG0425	Belongs to the sulfur carrier protein TusA family
DV401_RS05130	COG3945	hemerythrin HHE cation binding domain
DV401_RS05145	COG0641	radical SAM
DV401_RS05150	COG3392	D12 class N6 adenine-specific DNA methyltransferase
DV401_RS05155	COG4416	COG NOG18757 non supervised orthologous group
DV401_RS05170	COG0754	glutathionylspermidine amidase activity
DV401_RS05175	COG1114	Component of the transport system for branched-chain amino acids
DV401_RS05185	COG1522	sequence-specific DNA binding
DV401_RS05190	COG2962	Rard protein
DV401_RS05200	COG0516	GMP reductase activity
DV401_RS05200	COG0517	IMP dehydrogenase activity
DV401_RS05205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DV401_RS05205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DV401_RS05235	COG1573	uracil-dna glycosylase
DV401_RS05245	COG3059	membrane
DV401_RS05260	COG1943	Transposase
DV401_RS05275	COG0339	signal peptide processing
DV401_RS05280	COG2832	Protein of unknown function (DUF454)
DV401_RS05285	COG4166	transmembrane transport
DV401_RS05295	COG0671	phosphoesterase, PA-phosphatase related
DV401_RS05300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DV401_RS05305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DV401_RS05315	COG0737	Belongs to the 5'-nucleotidase family
DV401_RS05350	COG1560	Kdo2-lipid A biosynthetic process
DV401_RS05355	COG0730	response to heat
DV401_RS05360	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DV401_RS05370	COG3264	Mechanosensitive ion channel
DV401_RS05370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DV401_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
DV401_RS05380	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DV401_RS05385	COG0596	Alpha beta hydrolase
DV401_RS05390	COG0716	FMN binding
DV401_RS05395	COG0735	belongs to the Fur family
DV401_RS05400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DV401_RS05405	COG0805	protein transport
DV401_RS05420	COG0789	Transcriptional regulator
DV401_RS05425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DV401_RS05430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DV401_RS05435	COG1115	amino acid carrier protein
DV401_RS05445	COG2116	formate transmembrane transporter activity
DV401_RS05450	COG1882	Formate acetyltransferase
DV401_RS05455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DV401_RS05465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DV401_RS05470	COG0564	pseudouridine synthase activity
DV401_RS05475	COG1496	oxidoreductase activity
DV401_RS05485	COG2991	Protein conserved in bacteria
DV401_RS05490	COG1477	protein flavinylation
DV401_RS05495	COG2871	sodium ion transport
DV401_RS05510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DV401_RS05525	COG0271	Belongs to the BolA IbaG family
DV401_RS05530	COG3056	Lipoprotein
DV401_RS05535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV401_RS05540	COG0688	phosphatidylethanolamine metabolic process
DV401_RS05545	COG1399	metal-binding, possibly nucleic acid-binding protein
DV401_RS05570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DV401_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
DV401_RS05585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DV401_RS05590	COG2091	lysine biosynthetic process via aminoadipic acid
DV401_RS05595	COG0330	HflC and HflK could
DV401_RS05600	COG0330	HflC and HflK could
DV401_RS05605	COG2020	methyltransferase activity
DV401_RS05615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DV401_RS05615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DV401_RS05625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DV401_RS05635	COG1737	Transcriptional regulator
DV401_RS05640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DV401_RS05650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DV401_RS05665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DV401_RS05680	COG1160	GTP binding
DV401_RS05705	COG2252	PERMEase
DV401_RS05710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DV401_RS05730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DV401_RS05735	COG0626	cystathionine gamma-synthase activity
DV401_RS05740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DV401_RS05745	COG5413	integral membrane protein
DV401_RS05750	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DV401_RS05755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DV401_RS05760	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DV401_RS05810	COG1629	transport
DV401_RS05820	COG0625	glutathione transferase activity
DV401_RS05830	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
DV401_RS05835	COG3610	response to peptide
DV401_RS05840	COG3610	response to peptide
DV401_RS05845	COG4536	flavin adenine dinucleotide binding
DV401_RS05850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DV401_RS05855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DV401_RS05865	COG1393	Belongs to the ArsC family
DV401_RS05870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DV401_RS05875	COG1876	peptidase activity
DV401_RS05880	COG3842	ATPase activity
DV401_RS05885	COG1178	ABC-type Fe3 transport system permease component
DV401_RS05890	COG1840	ABC-type Fe3 transport system, periplasmic component
DV401_RS05895	COG4797	methyltransferase
DV401_RS05900	COG2226	methyltransferase
DV401_RS05910	COG2610	gluconate transmembrane transporter activity
DV401_RS05915	COG1929	Belongs to the glycerate kinase type-1 family
DV401_RS05920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DV401_RS05925	COG0460	homoserine dehydrogenase
DV401_RS05925	COG0527	aspartate kinase activity
DV401_RS05935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DV401_RS05960	COG0626	cystathionine gamma-synthase activity
DV401_RS05965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV401_RS05970	COG3118	belongs to the thioredoxin family
DV401_RS05985	COG0084	hydrolase, TatD family'
DV401_RS05990	COG3692	DNA binding
DV401_RS05995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DV401_RS06005	COG1946	Acyl-CoA thioesterase
DV401_RS06010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DV401_RS06010	COG1328	CTP reductase activity
DV401_RS06015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DV401_RS06020	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DV401_RS06025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DV401_RS06035	COG0497	DNA recombination
DV401_RS06040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DV401_RS06045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DV401_RS06055	COG0860	N-Acetylmuramoyl-L-alanine amidase
DV401_RS06055	COG1388	LysM domain
DV401_RS06060	COG0802	atpase or kinase
DV401_RS06065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DV401_RS06070	COG0617	tRNA 3'-terminal CCA addition
DV401_RS06075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DV401_RS06080	COG2333	competence protein COMEC
DV401_RS06080	COG0658	competence protein
DV401_RS06105	COG0861	Integral membrane protein TerC family
DV401_RS06115	COG2186	Transcriptional regulator
DV401_RS06130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DV401_RS06140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DV401_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
DV401_RS06155	COG0800	Aldolase
DV401_RS06160	COG2824	Alkylphosphonate utilization operon protein PhnA
DV401_RS06165	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DV401_RS06175	COG0670	Belongs to the BI1 family
DV401_RS06185	COG0564	pseudouridine synthase activity
DV401_RS06190	COG0708	Exodeoxyribonuclease III
DV401_RS06195	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
DV401_RS06200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DV401_RS06205	COG1792	Involved in formation and maintenance of cell shape
DV401_RS06210	COG1077	Cell shape determining protein MreB Mrl
DV401_RS06215	COG4178	(ABC) transporter
DV401_RS06225	COG0799	negative regulation of ribosome biogenesis
DV401_RS06235	COG0768	penicillin binding
DV401_RS06240	COG0772	Belongs to the SEDS family
DV401_RS06245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DV401_RS06245	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DV401_RS06250	COG1686	Belongs to the peptidase S11 family
DV401_RS06270	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DV401_RS06280	COG2301	Belongs to the HpcH HpaI aldolase family
DV401_RS06285	COG3051	citrate lyase alpha subunit
DV401_RS06290	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
DV401_RS06290	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DV401_RS06295	COG0471	metal ion transport
DV401_RS06320	COG0681	Belongs to the peptidase S26 family
DV401_RS06325	COG0571	ribonuclease III activity
DV401_RS06340	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
DV401_RS06345	COG0456	acetyltransferase
DV401_RS06355	COG2864	formate dehydrogenase
DV401_RS06360	COG0437	4 iron, 4 sulfur cluster binding
DV401_RS06375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DV401_RS06385	COG0561	phosphatase activity
DV401_RS06390	COG1022	Amp-dependent synthetase and ligase
DV401_RS06395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DV401_RS06400	COG0194	GDP metabolic process
DV401_RS06405	COG1758	RNA polymerase activity
DV401_RS06410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV401_RS06415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DV401_RS06455	COG0583	DNA-binding transcription factor activity
DV401_RS06460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DV401_RS06465	COG1687	branched-chain amino acid
DV401_RS06480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DV401_RS06485	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DV401_RS06495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DV401_RS06500	COG1984	allophanate hydrolase subunit 2
DV401_RS06505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DV401_RS06510	COG1914	H( )-stimulated, divalent metal cation uptake system
DV401_RS06525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DV401_RS06530	COG3112	Uncharacterised protein family (UPF0231)
DV401_RS06540	COG0024	Methionine aminopeptidase
DV401_RS06545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DV401_RS06555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DV401_RS06580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV401_RS06585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DV401_RS06590	COG2190	(PTS) system
DV401_RS06600	COG3111	PFAM Bacterial OB fold (BOF) protein
DV401_RS06605	COG0745	RESPONSE REGULATOR receiver
DV401_RS06610	COG0642	Histidine kinase
DV401_RS06615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV401_RS06625	COG0795	lipopolysaccharide-transporting ATPase activity
DV401_RS06630	COG0795	lipopolysaccharide-transporting ATPase activity
DV401_RS06645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DV401_RS06650	COG2244	polysaccharide biosynthetic process
DV401_RS06660	COG0438	transferase activity, transferring glycosyl groups
DV401_RS06665	COG3306	glycosyltransferase involved in LPS biosynthesis
DV401_RS06670	COG1216	Glycosyl transferase, family 2
DV401_RS06675	COG1216	Glycosyl transferase, family 2
DV401_RS06680	COG2005	Transcriptional regulator
DV401_RS06685	COG0725	ABC transporter, periplasmic molybdate-binding protein
DV401_RS06690	COG4149	molybdate abc transporter
DV401_RS06695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DV401_RS06700	COG0733	neurotransmitter:sodium symporter activity
DV401_RS06705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DV401_RS06710	COG4660	Part of a membrane complex involved in electron transport
DV401_RS06715	COG4659	FMN binding
DV401_RS06720	COG4658	electron transport chain
DV401_RS06725	COG4656	Part of a membrane complex involved in electron transport
DV401_RS06735	COG4657	Part of a membrane complex involved in electron transport
DV401_RS06740	COG0616	signal peptide processing
DV401_RS06750	COG1289	transmembrane transporter activity
DV401_RS06755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DV401_RS06760	COG0517	IMP dehydrogenase activity
DV401_RS06760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DV401_RS06770	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DV401_RS06775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DV401_RS06780	COG0315	cyclic pyranopterin monophosphate synthase activity
DV401_RS06785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DV401_RS06790	COG0314	molybdopterin synthase activity
DV401_RS06795	COG3008	intermembrane lipid transfer
DV401_RS06800	COG2995	paraquat-inducible protein a
DV401_RS06810	COG0793	Belongs to the peptidase S41A family
DV401_RS06815	COG2989	Protein conserved in bacteria
DV401_RS06820	COG3108	Peptidase M15
DV401_RS06825	COG0084	hydrolase, TatD family'
DV401_RS06830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV401_RS06835	COG0567	Dehydrogenase, E1 component
DV401_RS06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV401_RS06845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV401_RS06850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV401_RS06855	COG2823	Periplasmic or secreted lipoprotein
DV401_RS06860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DV401_RS06870	COG3107	peptidoglycan biosynthetic process
DV401_RS06875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DV401_RS06885	COG0791	NLP P60 protein
DV401_RS06895	COG2198	Histidine kinase
DV401_RS06905	COG0277	FAD linked oxidase domain protein
DV401_RS06925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DV401_RS06930	COG0101	tRNA pseudouridine synthase activity
DV401_RS06935	COG2855	membrane
DV401_RS06940	COG4172	Belongs to the ABC transporter superfamily
DV401_RS06945	COG4172	Belongs to the ABC transporter superfamily
DV401_RS06950	COG4171	peptide transport system, permease
DV401_RS06955	COG4168	peptide transport system, permease
DV401_RS06960	COG4166	transmembrane transport
DV401_RS06965	COG3106	COG3106 Predicted ATPase
DV401_RS06970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DV401_RS06990	COG0527	aspartate kinase activity
DV401_RS07025	COG3105	Protein conserved in bacteria
DV401_RS07030	COG0251	oxidation-reduction process
DV401_RS07045	COG0789	Transcriptional regulator
DV401_RS07050	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
DV401_RS07055	COG0310	cobalt ion transport
DV401_RS07060	COG0310	cobalt ion transport
DV401_RS07065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DV401_RS07070	COG1122	ATPase activity
DV401_RS07080	COG1448	Aminotransferase
DV401_RS07085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DV401_RS07090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DV401_RS07095	COG0308	aminopeptidase N
DV401_RS07100	COG0307	riboflavin synthase, alpha
DV401_RS07105	COG0534	Mate efflux family protein
DV401_RS07120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DV401_RS07125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DV401_RS07140	COG4991	sh3 domain protein
DV401_RS07145	COG0306	phosphate transporter
DV401_RS07150	COG1392	Phosphate transport regulator
DV401_RS07155	COG2259	Doxx family
DV401_RS07165	COG3220	belongs to the UPF0276 family
DV401_RS07170	COG3219	Protein conserved in bacteria
DV401_RS07175	COG3025	triphosphatase activity
DV401_RS07180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DV401_RS07185	COG1522	sequence-specific DNA binding
DV401_RS07190	COG1674	ftsk spoiiie
DV401_RS07200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DV401_RS07210	COG0788	formyltetrahydrofolate deformylase activity
DV401_RS07215	COG2916	Histone family protein nucleoid-structuring protein H-NS
DV401_RS07220	COG1757	Na H antiporter
DV401_RS07230	COG0028	Belongs to the TPP enzyme family
DV401_RS07235	COG0440	acetolactate synthase activity
DV401_RS07240	COG0018	arginyl-trna synthetase
DV401_RS07245	COG3102	Protein conserved in bacteria
DV401_RS07255	COG3133	Outer membrane lipoprotein
DV401_RS07260	COG1216	Glycosyl transferase, family 2
DV401_RS07275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DV401_RS07280	COG0305	Participates in initiation and elongation during chromosome replication
DV401_RS07285	COG0469	pyruvate kinase activity
DV401_RS07295	COG0582	viral genome integration into host DNA
DV401_RS07325	COG3723	Recombinational DNA repair protein, rece pathway
DV401_RS07340	COG3561	AntA/AntB antirepressor
DV401_RS07440	COG3561	AntA/AntB antirepressor
DV401_RS07460	COG3179	chitinase
DV401_RS07485	COG3646	Phage regulatory protein
DV401_RS07500	COG0740	serine-type endopeptidase activity
DV401_RS07615	COG4383	Mu-like prophage protein gp29
DV401_RS07620	COG2369	cell adhesion
DV401_RS07625	COG3101	peptidyl-lysine hydroxylation
DV401_RS07640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DV401_RS07645	COG1714	RDD family
DV401_RS07650	COG2890	protein-(glutamine-N5) methyltransferase activity
DV401_RS07655	COG2912	Transglutaminase-like superfamily
DV401_RS07660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DV401_RS07665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV401_RS07670	COG4591	ABC-type transport system involved in lipoprotein release permease component
DV401_RS07675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DV401_RS07685	COG2830	Protein of unknown function (DUF452)
DV401_RS07690	COG0500	methyltransferase
DV401_RS07695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DV401_RS07700	COG1136	(ABC) transporter
DV401_RS07705	COG4591	ABC-type transport system involved in lipoprotein release permease component
DV401_RS07710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DV401_RS07715	COG2932	Transcriptional regulator
DV401_RS07725	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV401_RS07730	COG3381	protein complex oligomerization
DV401_RS07735	COG0778	Nitroreductase
DV401_RS07740	COG0616	signal peptide processing
DV401_RS07745	COG3475	LICD family
DV401_RS07750	COG4750	Nucleotidyl transferase
DV401_RS07755	COG0697	spore germination
DV401_RS07760	COG0510	thiamine kinase activity
DV401_RS07765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DV401_RS07765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV401_RS07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV401_RS07775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DV401_RS07785	COG0786	glutamate:sodium symporter activity
DV401_RS07790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DV401_RS07795	COG0187	DNA topoisomerase II activity
DV401_RS07800	COG1560	Kdo2-lipid A biosynthetic process
DV401_RS07805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV401_RS07805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DV401_RS07830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DV401_RS07835	COG1177	transmembrane transport
DV401_RS07840	COG1176	ABC-type spermidine putrescine transport system, permease component I
DV401_RS07845	COG3842	ATPase activity
DV401_RS07855	COG0783	Belongs to the Dps family
DV401_RS07875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DV401_RS07880	COG1530	ribonuclease E activity
DV401_RS07890	COG2983	Belongs to the UPF0260 family
DV401_RS07895	COG1640	4-alpha-glucanotransferase
DV401_RS07905	COG1523	belongs to the glycosyl hydrolase 13 family
DV401_RS07910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DV401_RS07920	COG0058	SHG alpha-glucan phosphorylase activity
DV401_RS07925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DV401_RS07930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DV401_RS07935	COG0583	DNA-binding transcription factor activity
DV401_RS07940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DV401_RS07950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DV401_RS07955	COG0612	Peptidase, M16
DV401_RS07960	COG4771	TonB-dependent receptor
DV401_RS07965	COG3585	molybdate ion transport
DV401_RS07970	COG2920	part of a sulfur-relay system
DV401_RS07975	COG0037	tRNA processing
DV401_RS07980	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
DV401_RS07985	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DV401_RS08000	COG0697	spore germination
DV401_RS08005	COG2925	Exonuclease
DV401_RS08010	COG5002	protein histidine kinase activity
DV401_RS08015	COG0745	RESPONSE REGULATOR receiver
DV401_RS08025	COG0581	inorganic phosphate transmembrane transporter activity
DV401_RS08030	COG0573	inorganic phosphate transmembrane transporter activity
DV401_RS08035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DV401_RS08040	COG1528	Iron-storage protein
DV401_RS08045	COG1528	Iron-storage protein
DV401_RS08055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV401_RS08060	COG0512	Glutamine amidotransferase of anthranilate synthase
DV401_RS08065	COG1942	4-Oxalocrotonate Tautomerase
DV401_RS08070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DV401_RS08075	COG0135	phosphoribosylanthranilate isomerase activity
DV401_RS08075	COG0134	indole-3-glycerol-phosphate synthase activity
DV401_RS08080	COG0298	carbon dioxide binding
DV401_RS08090	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DV401_RS08100	COG3097	Belongs to the UPF0267 family
DV401_RS08110	COG4185	zeta toxin
DV401_RS08115	COG2927	DNA polymerase III (CHI subunit)
DV401_RS08120	COG0114	fumarate hydratase activity
DV401_RS08125	COG2268	Band 7 protein
DV401_RS08130	COG0613	PHP domain protein
DV401_RS08170	COG3566	protein conserved in bacteria
DV401_RS08200	COG3567	Phage-associated protein, HI1409 family
DV401_RS08225	COG3179	chitinase
DV401_RS08325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DV401_RS08330	COG0589	response to stress
DV401_RS08335	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
DV401_RS08340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DV401_RS08350	COG4221	oxidoreductase activity
DV401_RS08360	COG0159	tryptophan synthase activity
DV401_RS08375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DV401_RS08380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DV401_RS08385	COG1278	Cold shock
DV401_RS08395	COG0564	pseudouridine synthase activity
DV401_RS08400	COG3098	single-species biofilm formation
DV401_RS08410	COG1722	exodeoxyribonuclease VII activity
DV401_RS08415	COG0142	geranyltranstransferase activity
DV401_RS08420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DV401_RS08425	COG2969	positive regulation of protein catabolic process
DV401_RS08430	COG0625	glutathione transferase activity
DV401_RS08445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DV401_RS08450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DV401_RS08455	COG3100	YcgL domain-containing protein
DV401_RS08460	COG0302	gtp cyclohydrolase
DV401_RS08465	COG0303	'Molybdopterin
DV401_RS08470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DV401_RS08475	COG3099	Belongs to the UPF0263 family
DV401_RS08480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV401_RS08485	COG0785	Cytochrome C biogenesis protein
DV401_RS08490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DV401_RS08490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DV401_RS08500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DV401_RS08505	COG1476	TRANSCRIPTIONal
DV401_RS08515	COG1595	DNA-templated transcription, initiation
DV401_RS08530	COG1538	Outer membrane efflux protein
DV401_RS08540	COG2062	phosphohistidine phosphatase, SixA
DV401_RS08545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DV401_RS08550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DV401_RS08555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DV401_RS08565	COG1534	Rna-binding protein
DV401_RS08570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DV401_RS08575	COG2027	D-alanyl-D-alanine carboxypeptidase
DV401_RS08595	COG0515	serine threonine protein kinase
DV401_RS08605	COG1067	ATP-dependent peptidase activity
DV401_RS08615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DV401_RS08620	COG1074	ATP-dependent DNA helicase activity
DV401_RS08625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DV401_RS08630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DV401_RS08645	COG3119	arylsulfatase activity
DV401_RS08650	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DV401_RS08660	COG0798	PFAM Bile acid sodium symporter
DV401_RS08680	COG0640	Transcriptional regulator
DV401_RS08685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DV401_RS08690	COG1674	ftsk spoiiie
DV401_RS08710	COG0791	NLP P60 protein
DV401_RS08715	COG0776	regulation of translation
DV401_RS08735	COG0633	Ferredoxin
DV401_RS08745	COG1280	lysine exporter protein (LysE YggA)
DV401_RS08750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DV401_RS08755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DV401_RS08775	COG0288	reversible hydration of carbon dioxide
DV401_RS08780	COG0488	(ABC) transporter
DV401_RS08790	COG1346	cytolysis
DV401_RS08795	COG1380	Effector of murein hydrolase LrgA
DV401_RS08800	COG1525	nuclease
DV401_RS08805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DV401_RS08810	COG2166	iron-sulfur cluster assembly
DV401_RS08815	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DV401_RS08825	COG0287	Prephenate dehydrogenase
DV401_RS08825	COG1605	Chorismate mutase
DV401_RS08840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DV401_RS08865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DV401_RS08870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DV401_RS08875	COG0195	Participates in both transcription termination and antitermination
DV401_RS08900	COG1083	cytidylyl-transferase
DV401_RS08905	COG0778	Nitroreductase
DV401_RS08910	COG0489	protein tyrosine kinase activity
DV401_RS08915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DV401_RS08915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DV401_RS08930	COG0500	methyltransferase
DV401_RS08940	COG1944	ATP diphosphatase activity
DV401_RS08950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DV401_RS08955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DV401_RS08960	COG2949	membrane
DV401_RS08965	COG0285	dihydrofolate synthase activity
DV401_RS08975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV401_RS08980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DV401_RS08985	COG1444	tRNA N-acetyltransferase activity
DV401_RS08990	COG3094	Invasion gene expression up-regulator, SirB
DV401_RS08995	COG0488	(ABC) transporter
DV401_RS09000	COG3041	Addiction module toxin RelE StbE family
DV401_RS09005	COG3077	Addiction module antitoxin, RelB DinJ family
DV401_RS09010	COG3683	transport system, periplasmic component
DV401_RS09015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DV401_RS09030	COG1368	sulfuric ester hydrolase activity
DV401_RS09035	COG0280	phosphate acetyltransferase
DV401_RS09035	COG0281	malic enzyme
DV401_RS09040	COG3955	Domain of unknown function (DUF1919)
DV401_RS09050	COG1187	pseudouridine synthase activity
DV401_RS09055	COG2814	Major facilitator Superfamily
DV401_RS09065	COG2860	membrane
DV401_RS09070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DV401_RS09080	COG0443	Heat shock 70 kDa protein
DV401_RS09085	COG5339	Protein conserved in bacteria
DV401_RS09095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DV401_RS09100	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV401_RS09105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV401_RS09115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DV401_RS09125	COG2233	PERMEase
DV401_RS09130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DV401_RS09135	COG0023	Translation Initiation Factor
DV401_RS09140	COG0284	orotidine-5'-phosphate decarboxylase activity
DV401_RS09145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DV401_RS09150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DV401_RS09160	COG0539	negative regulation of cytoplasmic translation
DV401_RS09165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DV401_RS09170	COG1620	l-lactate permease
DV401_RS09175	COG4206	TonB-dependent receptor
DV401_RS09175	COG1629	transport
DV401_RS09180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DV401_RS09185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV401_RS09190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DV401_RS09195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV401_RS09220	COG1090	epimerase
DV401_RS09225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DV401_RS09230	COG1286	toxin biosynthetic process
DV401_RS09235	COG3092	negative regulation of chromosome organization
DV401_RS09240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DV401_RS09245	COG0857	belongs to the CobB CobQ family
DV401_RS09245	COG0280	phosphate acetyltransferase
DV401_RS09250	COG2840	Smr protein MutS2
DV401_RS09255	COG2890	protein-(glutamine-N5) methyltransferase activity
DV401_RS09260	COG0583	DNA-binding transcription factor activity
DV401_RS09265	COG1187	pseudouridine synthase activity
DV401_RS09270	COG0009	L-threonylcarbamoyladenylate synthase
DV401_RS09275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DV401_RS09285	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DV401_RS09290	COG0583	DNA-binding transcription factor activity
DV401_RS09295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DV401_RS09310	COG0720	synthase