locus-tag	class	description
CH556_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH556_RS00010	COG0592	DNA-directed DNA polymerase activity
CH556_RS00030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH556_RS00035	COG0473	3-isopropylmalate dehydrogenase activity
CH556_RS00040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH556_RS00045	COG0758	DNA mediated transformation
CH556_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH556_RS00085	COG2184	nucleotidyltransferase activity
CH556_RS00090	COG0697	spore germination
CH556_RS00095	COG4145	pantothenate transmembrane transporter activity
CH556_RS00100	COG3924	membrane
CH556_RS00105	COG0439	Biotin carboxylase
CH556_RS00110	COG0511	ligase activity, forming carbon-carbon bonds
CH556_RS00120	COG1441	menaquinone biosynthetic process
CH556_RS00125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH556_RS00150	COG0728	peptidoglycan biosynthetic process
CH556_RS00155	COG0196	riboflavin kinase activity
CH556_RS00165	COG0537	adenosine 5'-monophosphoramidase activity
CH556_RS00170	COG5633	Lipoprotein
CH556_RS00175	COG1472	Belongs to the glycosyl hydrolase 3 family
CH556_RS00185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH556_RS00205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH556_RS00210	COG2003	Belongs to the UPF0758 family
CH556_RS00225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH556_RS00235	COG1487	ribonuclease activity
CH556_RS00240	COG0076	glutamate decarboxylase activity
CH556_RS00250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH556_RS00255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH556_RS00255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH556_RS00260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH556_RS00265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH556_RS00280	COG4795	General secretion pathway protein
CH556_RS00285	COG2165	general secretion pathway protein
CH556_RS00290	COG0483	inositol monophosphate 1-phosphatase activity
CH556_RS00295	COG1138	Cytochrome C-type biogenesis protein
CH556_RS00300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH556_RS00305	COG4235	cytochrome complex assembly
CH556_RS00305	COG3088	subunit of a heme lyase
CH556_RS00310	COG2081	HI0933 family
CH556_RS00320	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
CH556_RS00330	COG0754	glutathionylspermidine amidase activity
CH556_RS00335	COG0753	catalase activity
CH556_RS00345	COG4545	Glutaredoxin-related protein
CH556_RS00350	COG2852	Protein conserved in bacteria
CH556_RS00375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH556_RS00380	COG2026	Addiction module toxin, RelE StbE family
CH556_RS00390	COG1466	dna polymerase III delta subunit
CH556_RS00395	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH556_RS00405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH556_RS00410	COG0575	Belongs to the CDS family
CH556_RS00415	COG0750	zinc metalloprotease
CH556_RS00425	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH556_RS00445	COG2226	methyltransferase
CH556_RS00450	COG0475	glutathione-regulated potassium exporter activity
CH556_RS00450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH556_RS00455	COG0494	nUDIX hydrolase
CH556_RS00470	COG4701	Protein of unknown function (DUF721)
CH556_RS00475	COG0590	tRNA wobble adenosine to inosine editing
CH556_RS00490	COG0730	response to heat
CH556_RS00505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH556_RS00510	COG1566	PFAM secretion protein HlyD family protein
CH556_RS00515	COG2814	Major facilitator Superfamily
CH556_RS00520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH556_RS00525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH556_RS00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH556_RS00535	COG1309	transcriptional regulator
CH556_RS00550	COG0237	dephospho-CoA kinase activity
CH556_RS00565	COG0151	Belongs to the GarS family
CH556_RS00570	COG0138	bifunctional purine biosynthesis protein purh
CH556_RS00575	COG2259	Doxx family
CH556_RS00585	COG0745	RESPONSE REGULATOR receiver
CH556_RS00590	COG1115	amino acid carrier protein
CH556_RS00595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH556_RS00600	COG0142	geranyltranstransferase activity
CH556_RS00615	COG0697	spore germination
CH556_RS00635	COG3307	-O-antigen
CH556_RS00640	COG1088	dTDP-glucose 4,6-dehydratase activity
CH556_RS00645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CH556_RS00660	COG1216	Glycosyl transferase, family 2
CH556_RS00665	COG0463	Glycosyl transferase, family 2
CH556_RS00670	COG2244	polysaccharide biosynthetic process
CH556_RS00680	COG0174	glutamine synthetase
CH556_RS00690	COG1217	gtp-binding protein TYPA
CH556_RS00700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH556_RS00710	COG0557	exoribonuclease II activity
CH556_RS00715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH556_RS00720	COG0542	response to heat
CH556_RS00725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH556_RS00740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH556_RS00740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH556_RS00750	COG0748	coenzyme F420 binding
CH556_RS00755	COG0747	negative chemotaxis
CH556_RS00760	COG2814	Major facilitator Superfamily
CH556_RS00765	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH556_RS00775	COG3086	response to oxidative stress
CH556_RS00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH556_RS00790	COG3085	chromosome segregation
CH556_RS00795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH556_RS00800	COG3084	Protein conserved in bacteria
CH556_RS00805	COG0746	molybdenum cofactor guanylyltransferase activity
CH556_RS00810	COG0402	S-adenosylhomocysteine deaminase activity
CH556_RS00815	COG3083	sulfuric ester hydrolase activity
CH556_RS00830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH556_RS00835	COG0745	RESPONSE REGULATOR receiver
CH556_RS00850	COG1053	succinate dehydrogenase
CH556_RS00855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH556_RS00860	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH556_RS00870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH556_RS00880	COG0741	lytic transglycosylase activity
CH556_RS00885	COG2350	Protein conserved in bacteria
CH556_RS00890	COG1607	acyl-coa hydrolase
CH556_RS00905	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH556_RS00910	COG1129	ABC transporter
CH556_RS00915	COG1879	ABC-type sugar transport system periplasmic component
CH556_RS00920	COG1609	Transcriptional regulator
CH556_RS00925	COG1085	galactose-1-phosphate uridylyltransferase
CH556_RS00930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH556_RS00935	COG2017	converts alpha-aldose to the beta-anomer
CH556_RS00940	COG3079	Belongs to the UPF0149 family
CH556_RS00945	COG0006	proline dipeptidase activity
CH556_RS00950	COG0589	response to stress
CH556_RS00965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH556_RS00995	COG0730	response to heat
CH556_RS01005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH556_RS01040	COG0201	protein transport
CH556_RS01125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH556_RS01145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH556_RS01150	COG0051	transcription antitermination factor activity, RNA binding
CH556_RS01155	COG1070	Carbohydrate kinase
CH556_RS01160	COG2390	Transcriptional regulator
CH556_RS01200	COG2177	Part of the ABC transporter FtsEX involved in
CH556_RS01205	COG2884	Cell division ATP-binding protein ftsE
CH556_RS01210	COG0552	protein localization to endoplasmic reticulum
CH556_RS01215	COG0742	ribosomal rna small subunit methyltransferase
CH556_RS01220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH556_RS01225	COG3306	glycosyltransferase involved in LPS biosynthesis
CH556_RS01235	COG3172	ATPase kinase involved in NAD metabolism
CH556_RS01240	COG2129	metallophosphoesterase
CH556_RS01265	COG1194	a g-specific adenine glycosylase
CH556_RS01280	COG4942	peptidase
CH556_RS01285	COG2861	carbohydrate metabolic process
CH556_RS01290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH556_RS01295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH556_RS01310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH556_RS01330	COG1252	NADH dehydrogenase
CH556_RS01335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH556_RS01340	COG0252	asparaginase activity
CH556_RS01345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH556_RS01355	COG0702	epimerase
CH556_RS01365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH556_RS01370	COG0587	DNA-directed DNA polymerase activity
CH556_RS01375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH556_RS01385	COG0028	Belongs to the TPP enzyme family
CH556_RS01395	COG0733	neurotransmitter:sodium symporter activity
CH556_RS01410	COG0204	Acyl-transferase
CH556_RS01430	COG0514	ATP-dependent DNA helicase (RecQ)
CH556_RS01445	COG0019	diaminopimelate decarboxylase activity
CH556_RS01450	COG2197	response regulator
CH556_RS01490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH556_RS01495	COG1739	Uncharacterized protein family UPF0029
CH556_RS01510	COG0251	oxidation-reduction process
CH556_RS01515	COG2853	Lipoprotein
CH556_RS01520	COG0250	Participates in transcription elongation, termination and antitermination
CH556_RS01525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH556_RS01530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH556_RS01550	COG3041	Addiction module toxin RelE StbE family
CH556_RS01555	COG3077	Addiction module antitoxin, RelB DinJ family
CH556_RS01565	COG3276	selenocysteine insertion sequence binding
CH556_RS01570	COG1921	L-seryl-tRNASec selenium transferase activity
CH556_RS01580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH556_RS01585	COG0814	amino acid
CH556_RS01600	COG1388	LysM domain
CH556_RS01600	COG4942	peptidase
CH556_RS01610	COG1238	metal cluster binding
CH556_RS01615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH556_RS01625	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH556_RS01630	COG1047	Peptidyl-prolyl cis-trans
CH556_RS01635	COG0729	surface antigen
CH556_RS01640	COG2911	Protein conserved in bacteria
CH556_RS01645	COG0248	Ppx GppA phosphatase
CH556_RS01650	COG1187	pseudouridine synthase activity
CH556_RS01655	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CH556_RS01660	COG0584	glycerophosphoryl diester phosphodiesterase
CH556_RS01670	COG0583	DNA-binding transcription factor activity
CH556_RS01675	COG2962	Rard protein
CH556_RS01690	COG0456	acetyltransferase
CH556_RS01695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH556_RS01700	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH556_RS01710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH556_RS01715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH556_RS01720	COG0584	glycerophosphoryl diester phosphodiesterase
CH556_RS01735	COG2271	Major facilitator Superfamily
CH556_RS01740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH556_RS01745	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH556_RS01750	COG0247	lactate metabolic process
CH556_RS01755	COG1120	ATPase activity
CH556_RS01760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH556_RS01775	COG2801	Transposase and inactivated derivatives
CH556_RS01805	COG0716	FMN binding
CH556_RS01815	COG1494	fructose-1,6-bisphosphatase
CH556_RS01825	COG3550	peptidyl-serine autophosphorylation
CH556_RS01830	COG3550	peptidyl-serine autophosphorylation
CH556_RS01835	COG1132	(ABC) transporter
CH556_RS01840	COG4988	ABC transporter
CH556_RS01845	COG4771	TonB-dependent receptor
CH556_RS01845	COG1629	transport
CH556_RS01850	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CH556_RS01855	COG3620	sequence-specific DNA binding
CH556_RS01860	COG0488	(ABC) transporter
CH556_RS01865	COG0551	DNA topoisomerase type I activity
CH556_RS01875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH556_RS01880	COG2818	Glycosylase
CH556_RS01885	COG0463	Glycosyl transferase, family 2
CH556_RS01890	COG1519	Transferase
CH556_RS01895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH556_RS01900	COG5645	(Lipo)protein
CH556_RS01905	COG0210	DNA helicase
CH556_RS01910	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH556_RS01915	COG1285	pathogenesis
CH556_RS01920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH556_RS01925	COG2267	carboxylic ester hydrolase activity
CH556_RS01950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH556_RS01965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH556_RS01975	COG0180	Tryptophanyl-tRNA synthetase
CH556_RS01980	COG3691	Protein conserved in bacteria
CH556_RS01985	COG4771	TonB-dependent receptor
CH556_RS01985	COG1629	transport
CH556_RS01995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH556_RS02000	COG0038	chloride channel
CH556_RS02030	COG1072	(Pantothenic acid kinase))
CH556_RS02035	COG3026	antisigma factor binding
CH556_RS02040	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH556_RS02045	COG1595	DNA-templated transcription, initiation
CH556_RS02050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH556_RS02055	COG1970	mechanosensitive ion channel activity
CH556_RS02060	COG0569	domain protein
CH556_RS02065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH556_RS02065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH556_RS02070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH556_RS02100	COG3070	regulator of competence-specific genes
CH556_RS02120	COG0561	phosphatase activity
CH556_RS02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH556_RS02130	COG0549	Belongs to the carbamate kinase family
CH556_RS02135	COG1288	antiporter activity
CH556_RS02155	COG3069	C4-dicarboxylate transmembrane transporter activity
CH556_RS02160	COG1473	amidohydrolase
CH556_RS02165	COG0737	Belongs to the 5'-nucleotidase family
CH556_RS02180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH556_RS02200	COG2168	tRNA wobble position uridine thiolation
CH556_RS02205	COG2923	Belongs to the DsrF TusC family
CH556_RS02210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH556_RS02215	COG2964	Protein conserved in bacteria
CH556_RS02220	COG0545	Peptidyl-prolyl cis-trans isomerase
CH556_RS02230	COG0678	peroxiredoxin activity
CH556_RS02230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH556_RS02235	COG0583	DNA-binding transcription factor activity
CH556_RS02240	COG1309	transcriptional regulator
CH556_RS02245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH556_RS02250	COG2183	response to ionizing radiation
CH556_RS02255	COG0187	DNA topoisomerase II activity
CH556_RS02260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH556_RS02265	COG0546	phosphoglycolate phosphatase activity
CH556_RS02275	COG1522	sequence-specific DNA binding
CH556_RS02280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH556_RS02285	COG1297	OPT oligopeptide transporter protein
CH556_RS02295	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH556_RS02300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH556_RS02305	COG0363	glucosamine-6-phosphate deaminase activity
CH556_RS02315	COG1943	Transposase
CH556_RS02320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH556_RS02330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH556_RS02335	COG3306	glycosyltransferase involved in LPS biosynthesis
CH556_RS02340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH556_RS02400	COG0804	urea catabolic process
CH556_RS02415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH556_RS02425	COG1027	Aspartate ammonia-lyase
CH556_RS02430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH556_RS02435	COG0358	DNA primase activity
CH556_RS02445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH556_RS02450	COG1435	thymidine kinase activity
CH556_RS02455	COG0814	amino acid
CH556_RS02460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH556_RS02465	COG3719	Belongs to the RNase T2 family
CH556_RS02475	COG0191	fructose-bisphosphate aldolase activity
CH556_RS02480	COG0859	PFAM glycosyl transferase family 9
CH556_RS02485	COG2364	Membrane
CH556_RS02490	COG1328	CTP reductase activity
CH556_RS02495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH556_RS02500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH556_RS02540	COG1275	C4-dicarboxylate transporter malic acid transport protein
CH556_RS02545	COG1720	tRNA m6t6A37 methyltransferase activity
CH556_RS02550	COG1575	Belongs to the MenA family. Type 1 subfamily
CH556_RS02565	COG1609	Transcriptional regulator
CH556_RS02570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH556_RS02575	COG1879	ABC-type sugar transport system periplasmic component
CH556_RS02580	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH556_RS02585	COG1129	ABC transporter
CH556_RS02590	COG1869	D-ribose catabolic process
CH556_RS02595	COG1322	Protein conserved in bacteria
CH556_RS02600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH556_RS02605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH556_RS02620	COG3700	Belongs to the class B bacterial acid phosphatase family
CH556_RS02635	COG1238	metal cluster binding
CH556_RS02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH556_RS02655	COG3312	ion transport
CH556_RS02680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH556_RS02700	COG0814	amino acid
CH556_RS02705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH556_RS02705	COG0140	phosphoribosyl-ATP diphosphatase activity
CH556_RS02710	COG0107	imidazoleglycerol-phosphate synthase activity
CH556_RS02730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH556_RS02740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH556_RS02745	COG1561	YicC-like family, N-terminal region
CH556_RS02750	COG0354	folic acid binding
CH556_RS02755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH556_RS02765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH556_RS02770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH556_RS02775	COG2990	Protein conserved in bacteria
CH556_RS02780	COG3956	TIGRFAM MazG family protein
CH556_RS02785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CH556_RS02790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH556_RS02795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH556_RS02800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH556_RS02805	COG0470	DNA polymerase III
CH556_RS02810	COG0084	hydrolase, TatD family'
CH556_RS02820	COG1253	flavin adenine dinucleotide binding
CH556_RS02830	COG3309	Virulence-associated protein D
CH556_RS02840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH556_RS02840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH556_RS02845	COG1105	Belongs to the carbohydrate kinase PfkB family
CH556_RS02850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH556_RS02850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH556_RS02850	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH556_RS02860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH556_RS02865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH556_RS02875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH556_RS02880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH556_RS02885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH556_RS02890	COG4972	Pilus assembly protein
CH556_RS02895	COG3166	PFAM Fimbrial assembly family protein
CH556_RS02910	COG4796	Type ii and iii secretion system protein
CH556_RS02915	COG1040	competence protein
CH556_RS02930	COG3068	Protein conserved in bacteria
CH556_RS02935	COG0776	regulation of translation
CH556_RS02940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH556_RS02950	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH556_RS02960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH556_RS02965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH556_RS02975	COG0513	Belongs to the DEAD box helicase family
CH556_RS02980	COG0826	peptidase U32
CH556_RS02985	COG0477	Major facilitator Superfamily
CH556_RS02995	COG0351	phosphomethylpyrimidine kinase
CH556_RS03005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH556_RS03010	COG1530	ribonuclease E activity
CH556_RS03015	COG0564	pseudouridine synthase activity
CH556_RS03020	COG1923	regulation of RNA biosynthetic process
CH556_RS03025	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CH556_RS03030	COG0739	heme binding
CH556_RS03035	COG1121	(ABC) transporter
CH556_RS03040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH556_RS03065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH556_RS03075	COG3691	Protein conserved in bacteria
CH556_RS03080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH556_RS03085	COG0494	nUDIX hydrolase
CH556_RS03095	COG2850	peptidyl-arginine hydroxylation
CH556_RS03110	COG0012	GTP binding
CH556_RS03115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CH556_RS03120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH556_RS03125	COG0318	PFAM AMP-dependent synthetase and ligase
CH556_RS03130	COG3065	identical protein binding
CH556_RS03135	COG1214	PFAM Peptidase M22, glycoprotease
CH556_RS03140	COG1199	ATP-dependent helicase activity
CH556_RS03145	COG0824	Thioesterase
CH556_RS03150	COG0811	peptide transport
CH556_RS03155	COG0848	biopolymer transport protein
CH556_RS03160	COG3064	Membrane
CH556_RS03165	COG0823	Involved in the tonB-independent uptake of proteins
CH556_RS03170	COG2885	chlorophyll binding
CH556_RS03185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH556_RS03190	COG1959	2 iron, 2 sulfur cluster binding
CH556_RS03200	COG0822	iron-sulfur transferase activity
CH556_RS03205	COG0316	Belongs to the HesB IscA family
CH556_RS03210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH556_RS03220	COG0443	Heat shock 70 kDa protein
CH556_RS03225	COG0633	Ferredoxin
CH556_RS03230	COG2975	iron-sulfur cluster assembly
CH556_RS03235	COG2976	Protein conserved in bacteria
CH556_RS03250	COG1426	Protein conserved in bacteria
CH556_RS03255	COG3063	Type IV pilus biogenesis stability protein PilW
CH556_RS03260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH556_RS03265	COG1686	Belongs to the peptidase S11 family
CH556_RS03275	COG1121	(ABC) transporter
CH556_RS03280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH556_RS03285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH556_RS03290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CH556_RS03295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH556_RS03300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH556_RS03305	COG1116	anion transmembrane transporter activity
CH556_RS03315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH556_RS03320	COG2814	Major facilitator Superfamily
CH556_RS03330	COG3005	denitrification pathway
CH556_RS03335	COG3043	anaerobic respiration
CH556_RS03340	COG0348	domain, Protein
CH556_RS03345	COG0437	4 iron, 4 sulfur cluster binding
CH556_RS03355	COG3062	negative regulation of establishment of protein localization
CH556_RS03360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH556_RS03365	COG3171	Protein conserved in bacteria
CH556_RS03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH556_RS03375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH556_RS03380	COG0628	permease
CH556_RS03385	COG0347	Belongs to the P(II) protein family
CH556_RS03390	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH556_RS03395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH556_RS03400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH556_RS03425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH556_RS03430	COG1381	Involved in DNA repair and RecF pathway recombination
CH556_RS03440	COG3266	domain, Protein
CH556_RS03440	COG3061	Opacity-associated protein A
CH556_RS03445	COG1509	lysine 2,3-aminomutase activity
CH556_RS03465	COG2056	Na+-H+ antiporter family
CH556_RS03475	COG0346	lactoylglutathione lyase activity
CH556_RS03495	COG1755	Isoprenylcysteine carboxyl methyltransferase
CH556_RS03500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH556_RS03505	COG0494	nUDIX hydrolase
CH556_RS03535	COG4974	Belongs to the 'phage' integrase family
CH556_RS03540	COG2814	Major facilitator Superfamily
CH556_RS03545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH556_RS03565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH556_RS03570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH556_RS03575	COG4535	Mg2 and Co2 transporter CorC
CH556_RS03580	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH556_RS03585	COG4969	Belongs to the N-Me-Phe pilin family
CH556_RS03590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH556_RS03595	COG1459	type II secretion system
CH556_RS03600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH556_RS03605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH556_RS03615	COG0789	Transcriptional regulator
CH556_RS03620	COG2608	mercury ion transmembrane transporter activity
CH556_RS03625	COG2608	mercury ion transmembrane transporter activity
CH556_RS03630	COG2608	mercury ion transmembrane transporter activity
CH556_RS03635	COG2608	mercury ion transmembrane transporter activity
CH556_RS03640	COG2217	Heavy metal translocating P-type atpase
CH556_RS03645	COG0814	amino acid
CH556_RS03650	COG1760	l-serine dehydratase
CH556_RS03655	COG0814	amino acid
CH556_RS03660	COG0436	Aminotransferase
CH556_RS03670	COG1169	isochorismate synthase
CH556_RS03680	COG2267	carboxylic ester hydrolase activity
CH556_RS03685	COG0477	Major facilitator Superfamily
CH556_RS03690	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH556_RS03695	COG2258	MOSC domain
CH556_RS03700	COG3012	SEC-C Motif Domain Protein
CH556_RS03710	COG1368	sulfuric ester hydrolase activity
CH556_RS03735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH556_RS03755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH556_RS03760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH556_RS03765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH556_RS03775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH556_RS03780	COG3850	Histidine kinase
CH556_RS03790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH556_RS03795	COG3210	domain, Protein
CH556_RS03805	COG4771	TonB-dependent receptor
CH556_RS03810	COG0859	PFAM glycosyl transferase family 9
CH556_RS03820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH556_RS03830	COG1442	glycosyl transferase family 8
CH556_RS03840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH556_RS03845	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH556_RS03855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH556_RS03860	COG0811	peptide transport
CH556_RS03865	COG0848	biopolymer transport protein
CH556_RS03870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH556_RS03875	COG0629	single-stranded DNA binding
CH556_RS03880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH556_RS03890	COG0641	radical SAM
CH556_RS03905	COG3945	hemerythrin HHE cation binding domain
CH556_RS03910	COG0425	Belongs to the sulfur carrier protein TusA family
CH556_RS03915	COG1862	Preprotein translocase
CH556_RS03920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH556_RS03925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH556_RS03935	COG1393	Belongs to the ArsC family
CH556_RS03940	COG3036	rescue of stalled ribosome
CH556_RS03950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH556_RS03955	COG0513	Belongs to the DEAD box helicase family
CH556_RS03960	COG4785	May be involved in cell division
CH556_RS03975	COG2731	YhcH YjgK YiaL family protein
CH556_RS03980	COG1114	Component of the transport system for branched-chain amino acids
CH556_RS03990	COG1522	sequence-specific DNA binding
CH556_RS03995	COG2962	Rard protein
CH556_RS04005	COG0517	IMP dehydrogenase activity
CH556_RS04005	COG0516	GMP reductase activity
CH556_RS04010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH556_RS04010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH556_RS04055	COG3071	HemY protein
CH556_RS04060	COG2959	enzyme of heme biosynthesis
CH556_RS04065	COG3072	Adenylate cyclase
CH556_RS04075	COG1045	serine acetyltransferase
CH556_RS04080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH556_RS04085	COG0471	metal ion transport
CH556_RS04105	COG0738	Major facilitator superfamily
CH556_RS04110	COG0235	Class ii aldolase
CH556_RS04120	COG1070	Carbohydrate kinase
CH556_RS04125	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CH556_RS04130	COG1349	DNA-binding transcription factor activity
CH556_RS04140	COG0564	pseudouridine synthase activity
CH556_RS04145	COG0705	Rhomboid family
CH556_RS04150	COG1349	DNA-binding transcription factor activity
CH556_RS04155	COG1464	Belongs to the NlpA lipoprotein family
CH556_RS04170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH556_RS04195	COG1573	uracil-dna glycosylase
CH556_RS04205	COG3059	membrane
CH556_RS04220	COG1943	Transposase
CH556_RS04225	COG0732	type I restriction modification DNA specificity domain
CH556_RS04245	COG0339	signal peptide processing
CH556_RS04250	COG2832	Protein of unknown function (DUF454)
CH556_RS04255	COG4166	transmembrane transport
CH556_RS04265	COG0671	phosphoesterase, PA-phosphatase related
CH556_RS04270	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CH556_RS04275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CH556_RS04285	COG0737	Belongs to the 5'-nucleotidase family
CH556_RS04320	COG1560	Kdo2-lipid A biosynthetic process
CH556_RS04325	COG0730	response to heat
CH556_RS04330	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH556_RS04340	COG3264	Mechanosensitive ion channel
CH556_RS04340	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH556_RS04345	COG0318	PFAM AMP-dependent synthetase and ligase
CH556_RS04350	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH556_RS04355	COG0596	Alpha beta hydrolase
CH556_RS04360	COG0716	FMN binding
CH556_RS04365	COG0735	belongs to the Fur family
CH556_RS04370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CH556_RS04375	COG0805	protein transport
CH556_RS04390	COG0789	Transcriptional regulator
CH556_RS04395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CH556_RS04400	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CH556_RS04405	COG1115	amino acid carrier protein
CH556_RS04415	COG2116	formate transmembrane transporter activity
CH556_RS04420	COG1882	Formate acetyltransferase
CH556_RS04425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH556_RS04435	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH556_RS04440	COG0564	pseudouridine synthase activity
CH556_RS04445	COG1496	oxidoreductase activity
CH556_RS04455	COG2991	Protein conserved in bacteria
CH556_RS04460	COG1477	protein flavinylation
CH556_RS04480	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH556_RS04495	COG0271	Belongs to the BolA IbaG family
CH556_RS04500	COG3056	Lipoprotein
CH556_RS04505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH556_RS04510	COG0688	phosphatidylethanolamine metabolic process
CH556_RS04515	COG1399	metal-binding, possibly nucleic acid-binding protein
CH556_RS04530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH556_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
CH556_RS04545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH556_RS04550	COG2091	lysine biosynthetic process via aminoadipic acid
CH556_RS04555	COG0330	HflC and HflK could
CH556_RS04560	COG0330	HflC and HflK could
CH556_RS04565	COG2020	methyltransferase activity
CH556_RS04575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CH556_RS04575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CH556_RS04585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CH556_RS04590	COG1940	carbohydrate kinase activity
CH556_RS04595	COG1737	Transcriptional regulator
CH556_RS04600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH556_RS04610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH556_RS04630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH556_RS04645	COG1160	GTP binding
CH556_RS04650	COG2814	Major facilitator Superfamily
CH556_RS04670	COG2252	PERMEase
CH556_RS04675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH556_RS04695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH556_RS04700	COG0626	cystathionine gamma-synthase activity
CH556_RS04705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH556_RS04710	COG5413	integral membrane protein
CH556_RS04715	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH556_RS04720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH556_RS04725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH556_RS04785	COG2963	transposase activity
CH556_RS04795	COG0625	glutathione transferase activity
CH556_RS04805	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH556_RS04815	COG4536	flavin adenine dinucleotide binding
CH556_RS04820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH556_RS04850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH556_RS04860	COG1393	Belongs to the ArsC family
CH556_RS04870	COG1876	peptidase activity
CH556_RS04875	COG3842	ATPase activity
CH556_RS04880	COG1178	ABC-type Fe3 transport system permease component
CH556_RS04885	COG1840	ABC-type Fe3 transport system, periplasmic component
CH556_RS04895	COG2226	methyltransferase
CH556_RS04905	COG2610	gluconate transmembrane transporter activity
CH556_RS04910	COG1929	Belongs to the glycerate kinase type-1 family
CH556_RS04915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH556_RS04920	COG0527	aspartate kinase activity
CH556_RS04920	COG0460	homoserine dehydrogenase
CH556_RS04930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CH556_RS04955	COG0626	cystathionine gamma-synthase activity
CH556_RS04960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH556_RS04965	COG3118	belongs to the thioredoxin family
CH556_RS04975	COG0084	hydrolase, TatD family'
CH556_RS04980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH556_RS04990	COG2833	Protein of unknown function (DUF455)
CH556_RS04995	COG1946	Acyl-CoA thioesterase
CH556_RS05000	COG1328	CTP reductase activity
CH556_RS05000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH556_RS05005	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CH556_RS05010	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CH556_RS05015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH556_RS05025	COG0497	DNA recombination
CH556_RS05030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH556_RS05045	COG1388	LysM domain
CH556_RS05045	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH556_RS05050	COG0802	atpase or kinase
CH556_RS05055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH556_RS05060	COG0617	tRNA 3'-terminal CCA addition
CH556_RS05065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH556_RS05070	COG0658	competence protein
CH556_RS05070	COG2333	competence protein COMEC
CH556_RS05075	COG1132	(ABC) transporter
CH556_RS05095	COG0861	Integral membrane protein TerC family
CH556_RS05105	COG2186	Transcriptional regulator
CH556_RS05110	COG1063	alcohol dehydrogenase
CH556_RS05115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH556_RS05120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CH556_RS05125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CH556_RS05130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH556_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
CH556_RS05140	COG0800	Aldolase
CH556_RS05145	COG2824	Alkylphosphonate utilization operon protein PhnA
CH556_RS05160	COG0670	Belongs to the BI1 family
CH556_RS05165	COG3768	UPF0283 membrane protein
CH556_RS05170	COG0564	pseudouridine synthase activity
CH556_RS05175	COG0708	Exodeoxyribonuclease III
CH556_RS05180	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH556_RS05185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH556_RS05190	COG1792	Involved in formation and maintenance of cell shape
CH556_RS05195	COG1077	Cell shape determining protein MreB Mrl
CH556_RS05200	COG4178	(ABC) transporter
CH556_RS05210	COG0799	negative regulation of ribosome biogenesis
CH556_RS05220	COG0768	penicillin binding
CH556_RS05225	COG0772	Belongs to the SEDS family
CH556_RS05230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH556_RS05230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH556_RS05235	COG1686	Belongs to the peptidase S11 family
CH556_RS05255	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH556_RS05265	COG2301	Belongs to the HpcH HpaI aldolase family
CH556_RS05270	COG3051	citrate lyase alpha subunit
CH556_RS05275	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH556_RS05275	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH556_RS05280	COG0471	metal ion transport
CH556_RS05290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH556_RS05305	COG0681	Belongs to the peptidase S26 family
CH556_RS05325	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH556_RS05330	COG0456	acetyltransferase
CH556_RS05340	COG2864	formate dehydrogenase
CH556_RS05345	COG0437	4 iron, 4 sulfur cluster binding
CH556_RS05360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH556_RS05365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH556_RS05370	COG0561	phosphatase activity
CH556_RS05375	COG1022	Amp-dependent synthetase and ligase
CH556_RS05380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH556_RS05385	COG0194	GDP metabolic process
CH556_RS05395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH556_RS05400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH556_RS05440	COG0583	DNA-binding transcription factor activity
CH556_RS05445	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH556_RS05450	COG1687	branched-chain amino acid
CH556_RS05465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH556_RS05500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH556_RS05505	COG3112	Uncharacterised protein family (UPF0231)
CH556_RS05515	COG0024	Methionine aminopeptidase
CH556_RS05525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH556_RS05545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH556_RS05550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH556_RS05555	COG2190	(PTS) system
CH556_RS05565	COG3111	PFAM Bacterial OB fold (BOF) protein
CH556_RS05570	COG0745	RESPONSE REGULATOR receiver
CH556_RS05575	COG0642	Histidine kinase
CH556_RS05580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH556_RS05590	COG0795	lipopolysaccharide-transporting ATPase activity
CH556_RS05595	COG0795	lipopolysaccharide-transporting ATPase activity
CH556_RS05605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH556_RS05610	COG2244	polysaccharide biosynthetic process
CH556_RS05620	COG0438	transferase activity, transferring glycosyl groups
CH556_RS05625	COG3306	glycosyltransferase involved in LPS biosynthesis
CH556_RS05630	COG1216	Glycosyl transferase, family 2
CH556_RS05635	COG1216	Glycosyl transferase, family 2
CH556_RS05640	COG2005	Transcriptional regulator
CH556_RS05645	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH556_RS05650	COG4149	molybdate abc transporter
CH556_RS05655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CH556_RS05660	COG0733	neurotransmitter:sodium symporter activity
CH556_RS05665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH556_RS05670	COG4660	Part of a membrane complex involved in electron transport
CH556_RS05700	COG0616	signal peptide processing
CH556_RS05710	COG1289	transmembrane transporter activity
CH556_RS05715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH556_RS05720	COG0517	IMP dehydrogenase activity
CH556_RS05720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH556_RS05730	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CH556_RS05740	COG0315	cyclic pyranopterin monophosphate synthase activity
CH556_RS05745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH556_RS05750	COG0314	molybdopterin synthase activity
CH556_RS05755	COG3008	intermembrane lipid transfer
CH556_RS05760	COG2995	paraquat-inducible protein a
CH556_RS05770	COG0793	Belongs to the peptidase S41A family
CH556_RS05775	COG2989	Protein conserved in bacteria
CH556_RS05780	COG3108	Peptidase M15
CH556_RS05785	COG0084	hydrolase, TatD family'
CH556_RS05790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH556_RS05795	COG0567	Dehydrogenase, E1 component
CH556_RS05800	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH556_RS05805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH556_RS05810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH556_RS05815	COG2823	Periplasmic or secreted lipoprotein
CH556_RS05820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH556_RS05830	COG3107	peptidoglycan biosynthetic process
CH556_RS05835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH556_RS05845	COG0791	NLP P60 protein
CH556_RS05855	COG2198	Histidine kinase
CH556_RS05860	COG0277	FAD linked oxidase domain protein
CH556_RS05875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH556_RS05880	COG0539	negative regulation of cytoplasmic translation
CH556_RS05890	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH556_RS05895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH556_RS05905	COG0023	Translation Initiation Factor
CH556_RS05910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH556_RS05915	COG2233	PERMEase
CH556_RS05925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH556_RS05935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH556_RS05940	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH556_RS05945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH556_RS05955	COG5339	Protein conserved in bacteria
CH556_RS05960	COG0443	Heat shock 70 kDa protein
CH556_RS05965	COG0484	heat shock protein binding
CH556_RS05975	COG2860	membrane
CH556_RS05985	COG2814	Major facilitator Superfamily
CH556_RS05990	COG1187	pseudouridine synthase activity
CH556_RS05995	COG3955	Domain of unknown function (DUF1919)
CH556_RS06000	COG0281	malic enzyme
CH556_RS06000	COG0280	phosphate acetyltransferase
CH556_RS06005	COG1368	sulfuric ester hydrolase activity
CH556_RS06020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH556_RS06025	COG3683	transport system, periplasmic component
CH556_RS06030	COG3549	Plasmid maintenance system killer
CH556_RS06035	COG3093	addiction module antidote protein HigA
CH556_RS06040	COG0488	(ABC) transporter
CH556_RS06045	COG3094	Invasion gene expression up-regulator, SirB
CH556_RS06050	COG1444	tRNA N-acetyltransferase activity
CH556_RS06055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH556_RS06060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH556_RS06070	COG0285	dihydrofolate synthase activity
CH556_RS06075	COG2949	membrane
CH556_RS06080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CH556_RS06085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH556_RS06100	COG1944	ATP diphosphatase activity
CH556_RS06110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH556_RS06115	COG1120	ATPase activity
CH556_RS06120	COG0500	methyltransferase
CH556_RS06135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH556_RS06135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH556_RS06140	COG0489	protein tyrosine kinase activity
CH556_RS06145	COG0778	Nitroreductase
CH556_RS06150	COG1083	cytidylyl-transferase
CH556_RS06160	COG4695	Portal protein
CH556_RS06180	COG3617	BRO family, N-terminal domain
CH556_RS06215	COG3772	lysozyme
CH556_RS06290	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH556_RS06445	COG0195	Participates in both transcription termination and antitermination
CH556_RS06450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH556_RS06455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CH556_RS06475	COG0732	type I restriction modification DNA specificity domain
CH556_RS06480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CH556_RS06495	COG1605	Chorismate mutase
CH556_RS06495	COG0287	Prephenate dehydrogenase
CH556_RS06505	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CH556_RS06510	COG2166	iron-sulfur cluster assembly
CH556_RS06515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH556_RS06520	COG1525	nuclease
CH556_RS06530	COG1346	cytolysis
CH556_RS06540	COG0488	(ABC) transporter
CH556_RS06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH556_RS06550	COG1177	transmembrane transport
CH556_RS06555	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH556_RS06560	COG3842	ATPase activity
CH556_RS06570	COG0783	Belongs to the Dps family
CH556_RS06585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH556_RS06590	COG1530	ribonuclease E activity
CH556_RS06600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH556_RS06605	COG2983	Belongs to the UPF0260 family
CH556_RS06610	COG1640	4-alpha-glucanotransferase
CH556_RS06615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH556_RS06620	COG1523	belongs to the glycosyl hydrolase 13 family
CH556_RS06625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH556_RS06635	COG0058	SHG alpha-glucan phosphorylase activity
CH556_RS06640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH556_RS06645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH556_RS06650	COG0583	DNA-binding transcription factor activity
CH556_RS06655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH556_RS06665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH556_RS06670	COG0612	Peptidase, M16
CH556_RS06675	COG4771	TonB-dependent receptor
CH556_RS06680	COG3585	molybdate ion transport
CH556_RS06685	COG2920	part of a sulfur-relay system
CH556_RS06690	COG0037	tRNA processing
CH556_RS06695	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH556_RS06700	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH556_RS06725	COG0697	spore germination
CH556_RS06730	COG2925	Exonuclease
CH556_RS06735	COG5002	protein histidine kinase activity
CH556_RS06740	COG0745	RESPONSE REGULATOR receiver
CH556_RS06750	COG0581	inorganic phosphate transmembrane transporter activity
CH556_RS06755	COG0573	inorganic phosphate transmembrane transporter activity
CH556_RS06760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH556_RS06765	COG1528	Iron-storage protein
CH556_RS06770	COG1528	Iron-storage protein
CH556_RS06775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH556_RS06780	COG0512	Glutamine amidotransferase of anthranilate synthase
CH556_RS06785	COG1942	4-Oxalocrotonate Tautomerase
CH556_RS06790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH556_RS06795	COG0134	indole-3-glycerol-phosphate synthase activity
CH556_RS06795	COG0135	phosphoribosylanthranilate isomerase activity
CH556_RS06800	COG0298	carbon dioxide binding
CH556_RS06830	COG2927	DNA polymerase III (CHI subunit)
CH556_RS06835	COG0114	fumarate hydratase activity
CH556_RS06840	COG2268	Band 7 protein
CH556_RS06845	COG0613	PHP domain protein
CH556_RS06850	COG0167	dihydroorotate dehydrogenase activity
CH556_RS06935	COG3561	AntA/AntB antirepressor
CH556_RS06945	COG0582	viral genome integration into host DNA
CH556_RS06955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH556_RS06960	COG0589	response to stress
CH556_RS06965	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CH556_RS06970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH556_RS06980	COG4221	oxidoreductase activity
CH556_RS06995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH556_RS07000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH556_RS07005	COG1278	Cold shock
CH556_RS07015	COG0564	pseudouridine synthase activity
CH556_RS07020	COG3098	single-species biofilm formation
CH556_RS07035	COG0142	geranyltranstransferase activity
CH556_RS07045	COG2969	positive regulation of protein catabolic process
CH556_RS07050	COG0625	glutathione transferase activity
CH556_RS07065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CH556_RS07070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH556_RS07075	COG3100	YcgL domain-containing protein
CH556_RS07085	COG0303	'Molybdopterin
CH556_RS07090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH556_RS07095	COG3099	Belongs to the UPF0263 family
CH556_RS07100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH556_RS07105	COG0785	Cytochrome C biogenesis protein
CH556_RS07110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH556_RS07110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH556_RS07125	COG1595	DNA-templated transcription, initiation
CH556_RS07140	COG1538	Outer membrane efflux protein
CH556_RS07150	COG2062	phosphohistidine phosphatase, SixA
CH556_RS07155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH556_RS07160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH556_RS07165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH556_RS07175	COG1534	Rna-binding protein
CH556_RS07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH556_RS07185	COG2027	D-alanyl-D-alanine carboxypeptidase
CH556_RS07205	COG0515	serine threonine protein kinase
CH556_RS07215	COG1067	ATP-dependent peptidase activity
CH556_RS07225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH556_RS07230	COG1074	ATP-dependent DNA helicase activity
CH556_RS07235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CH556_RS07240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH556_RS07250	COG0676	glucose-6-phosphate 1-epimerase activity
CH556_RS07255	COG3119	arylsulfatase activity
CH556_RS07275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH556_RS07280	COG1674	ftsk spoiiie
CH556_RS07290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH556_RS07295	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CH556_RS07305	COG0791	NLP P60 protein
CH556_RS07310	COG0776	regulation of translation
CH556_RS07330	COG0633	Ferredoxin
CH556_RS07335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH556_RS07340	COG1280	lysine exporter protein (LysE YggA)
CH556_RS07345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH556_RS07350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH556_RS07360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH556_RS07370	COG0288	reversible hydration of carbon dioxide
CH556_RS07375	COG0488	(ABC) transporter
CH556_RS07380	COG0488	(ABC) transporter
CH556_RS07390	COG2166	iron-sulfur cluster assembly
CH556_RS07415	COG4774	siderophore transport
CH556_RS07420	COG4178	(ABC) transporter
CH556_RS07425	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH556_RS07430	COG1120	ATPase activity
CH556_RS07435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH556_RS07440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH556_RS07445	COG0157	Belongs to the NadC ModD family
CH556_RS07455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH556_RS07460	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH556_RS07465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH556_RS07465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH556_RS07470	COG1560	Kdo2-lipid A biosynthetic process
CH556_RS07475	COG0187	DNA topoisomerase II activity
CH556_RS07480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH556_RS07485	COG0786	glutamate:sodium symporter activity
CH556_RS07495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH556_RS07500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH556_RS07505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH556_RS07505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH556_RS07515	COG0697	spore germination
CH556_RS07520	COG4750	Nucleotidyl transferase
CH556_RS07525	COG3475	LICD family
CH556_RS07530	COG0616	signal peptide processing
CH556_RS07535	COG0778	Nitroreductase
CH556_RS07540	COG3381	protein complex oligomerization
CH556_RS07545	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH556_RS07555	COG2932	Transcriptional regulator
CH556_RS07560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH556_RS07565	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH556_RS07570	COG1136	(ABC) transporter
CH556_RS07575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH556_RS07580	COG0500	methyltransferase
CH556_RS07585	COG2830	Protein of unknown function (DUF452)
CH556_RS07595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CH556_RS07600	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH556_RS07605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH556_RS07615	COG2912	Transglutaminase-like superfamily
CH556_RS07620	COG2890	protein-(glutamine-N5) methyltransferase activity
CH556_RS07625	COG1714	RDD family
CH556_RS07630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH556_RS07655	COG3101	peptidyl-lysine hydroxylation
CH556_RS07660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH556_RS07670	COG5005	Phage virion morphogenesis
CH556_RS07680	COG2369	cell adhesion
CH556_RS07685	COG4383	Mu-like prophage protein gp29
CH556_RS07710	COG0469	pyruvate kinase activity
CH556_RS07715	COG0305	Participates in initiation and elongation during chromosome replication
CH556_RS07720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH556_RS07740	COG3133	Outer membrane lipoprotein
CH556_RS07750	COG3102	Protein conserved in bacteria
CH556_RS07755	COG0018	arginyl-trna synthetase
CH556_RS07760	COG0440	acetolactate synthase activity
CH556_RS07765	COG0028	Belongs to the TPP enzyme family
CH556_RS07775	COG1757	Na H antiporter
CH556_RS07780	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH556_RS07785	COG0788	formyltetrahydrofolate deformylase activity
CH556_RS07805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH556_RS07815	COG1674	ftsk spoiiie
CH556_RS07820	COG1522	sequence-specific DNA binding
CH556_RS07825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CH556_RS07830	COG3025	triphosphatase activity
CH556_RS07835	COG3219	Protein conserved in bacteria
CH556_RS07840	COG3220	belongs to the UPF0276 family
CH556_RS07850	COG2259	Doxx family
CH556_RS07855	COG1392	Phosphate transport regulator
CH556_RS07860	COG0306	phosphate transporter
CH556_RS07865	COG4991	sh3 domain protein
CH556_RS07875	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH556_RS07885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH556_RS07900	COG0534	Mate efflux family protein
CH556_RS07905	COG0307	riboflavin synthase, alpha
CH556_RS07910	COG0308	aminopeptidase N
CH556_RS07955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH556_RS07960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH556_RS07965	COG1448	Aminotransferase
CH556_RS07975	COG1122	ATPase activity
CH556_RS07980	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CH556_RS07985	COG0310	cobalt ion transport
CH556_RS07990	COG0310	cobalt ion transport
CH556_RS07995	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CH556_RS08000	COG0789	Transcriptional regulator
CH556_RS08005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CH556_RS08015	COG0251	oxidation-reduction process
CH556_RS08020	COG3105	Protein conserved in bacteria
CH556_RS08055	COG0527	aspartate kinase activity
CH556_RS08080	COG3106	COG3106 Predicted ATPase
CH556_RS08085	COG4166	transmembrane transport
CH556_RS08090	COG4168	peptide transport system, permease
CH556_RS08095	COG4171	peptide transport system, permease
CH556_RS08100	COG4172	Belongs to the ABC transporter superfamily
CH556_RS08105	COG4172	Belongs to the ABC transporter superfamily
CH556_RS08110	COG2855	membrane
CH556_RS08130	COG1620	l-lactate permease
CH556_RS08135	COG4206	TonB-dependent receptor
CH556_RS08135	COG1629	transport
CH556_RS08140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH556_RS08145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH556_RS08150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH556_RS08155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH556_RS08180	COG1090	epimerase
CH556_RS08185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH556_RS08190	COG1286	toxin biosynthetic process
CH556_RS08195	COG3092	negative regulation of chromosome organization
CH556_RS08200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH556_RS08205	COG0280	phosphate acetyltransferase
CH556_RS08205	COG0857	belongs to the CobB CobQ family
CH556_RS08210	COG2840	Smr protein MutS2
CH556_RS08215	COG2890	protein-(glutamine-N5) methyltransferase activity
CH556_RS08220	COG0583	DNA-binding transcription factor activity
CH556_RS08225	COG1187	pseudouridine synthase activity
CH556_RS08230	COG0009	L-threonylcarbamoyladenylate synthase
CH556_RS08235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH556_RS08245	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH556_RS08250	COG0583	DNA-binding transcription factor activity
CH556_RS08255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH556_RS08270	COG0720	synthase
CH556_RS08275	COG0602	queuosine metabolic process
CH556_RS08285	COG0210	DNA helicase
CH556_RS08290	COG0601	transmembrane transport
CH556_RS08295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH556_RS08300	COG0444	Belongs to the ABC transporter superfamily
CH556_RS08305	COG4608	Belongs to the ABC transporter superfamily
CH556_RS08310	COG1793	dna ligase
CH556_RS08320	COG1126	abc transporter atp-binding protein
CH556_RS08325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH556_RS08330	COG4215	(ABC) transporter
CH556_RS08335	COG4160	amino acid transport
CH556_RS08345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH556_RS08350	COG3091	SprT-like family
CH556_RS08360	COG0512	Glutamine amidotransferase of anthranilate synthase
CH556_RS08365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH556_RS08370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH556_RS08380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH556_RS08400	COG0247	lactate metabolic process
CH556_RS08400	COG0277	FAD linked oxidase domain protein
CH556_RS08415	COG2050	protein possibly involved in aromatic compounds catabolism
CH556_RS08425	COG3118	belongs to the thioredoxin family
CH556_RS08430	COG0492	ferredoxin-NADP+ reductase activity
CH556_RS08435	COG4988	ABC transporter
CH556_RS08440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH556_RS08450	COG0602	queuosine metabolic process
CH556_RS08455	COG1823	symporter activity
CH556_RS08460	COG1280	lysine exporter protein (LysE YggA)
CH556_RS08465	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH556_RS08470	COG0312	modulator of DNA gyrase
CH556_RS08480	COG3117	lipopolysaccharide transmembrane transporter activity
CH556_RS08485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH556_RS08490	COG1137	ATPase activity
CH556_RS08495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH556_RS08505	COG1605	Chorismate mutase
CH556_RS08505	COG0077	Prephenate dehydratase
CH556_RS08515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH556_RS08520	COG0849	cell division
CH556_RS08525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH556_RS08535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH556_RS08540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH556_RS08545	COG0772	Belongs to the SEDS family
CH556_RS08550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CH556_RS08560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH556_RS08570	COG0768	penicillin binding
CH556_RS08575	COG3116	cell division
CH556_RS08580	COG0275	rRNA processing
CH556_RS08590	COG1966	Carbon starvation protein
CH556_RS08605	COG4166	transmembrane transport
CH556_RS08610	COG0601	transmembrane transport
CH556_RS08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH556_RS08620	COG0444	Belongs to the ABC transporter superfamily
CH556_RS08625	COG4608	Belongs to the ABC transporter superfamily
CH556_RS08630	COG2990	Protein conserved in bacteria
CH556_RS08640	COG0606	chelatase, subunit chli
CH556_RS08650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH556_RS08660	COG1070	Carbohydrate kinase
CH556_RS08670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH556_RS08675	COG1757	Na H antiporter
CH556_RS08680	COG2207	Transcriptional regulator
CH556_RS08680	COG1609	Transcriptional regulator
CH556_RS08685	COG0859	PFAM glycosyl transferase family 9
CH556_RS08690	COG2814	Major facilitator Superfamily
CH556_RS08695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH556_RS08740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH556_RS08745	COG1138	Cytochrome C-type biogenesis protein
CH556_RS08755	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH556_RS08760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH556_RS08765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH556_RS08770	COG4133	protoheme IX ABC transporter activity
CH556_RS08775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH556_RS08780	COG1127	ABC transporter
CH556_RS08785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH556_RS08790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH556_RS08795	COG2854	intermembrane phospholipid transfer
CH556_RS08800	COG3113	response to antibiotic
CH556_RS08805	COG5007	Belongs to the BolA IbaG family
CH556_RS08815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH556_RS08820	COG0765	amino acid transport
CH556_RS08825	COG1126	abc transporter atp-binding protein
CH556_RS08830	COG3201	nicotinamide mononucleotide transporter
CH556_RS08845	COG1271	oxidase subunit
CH556_RS08850	COG1294	oxidase, subunit
CH556_RS08860	COG2363	Small membrane protein
CH556_RS08865	COG1643	Atp-dependent helicase
CH556_RS08870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH556_RS08875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH556_RS08880	COG0437	4 iron, 4 sulfur cluster binding
CH556_RS08885	COG3301	Polysulphide reductase, NrfD
CH556_RS08895	COG2194	sulfuric ester hydrolase activity
CH556_RS08900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH556_RS08905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH556_RS08920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CH556_RS08925	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CH556_RS08930	COG3421	Type III restriction
CH556_RS08935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH556_RS08940	COG4977	sequence-specific DNA binding
CH556_RS08940	COG1917	Cupin 2, conserved barrel domain protein
CH556_RS08945	COG1132	(ABC) transporter
CH556_RS08950	COG2608	mercury ion transmembrane transporter activity
CH556_RS08960	COG1305	Transglutaminase-like
CH556_RS08965	COG0243	molybdopterin cofactor binding
CH556_RS08970	COG0437	4 iron, 4 sulfur cluster binding
CH556_RS08975	COG3302	dmso reductase anchor subunit
CH556_RS08980	COG3381	protein complex oligomerization
CH556_RS08985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH556_RS08985	COG2221	Nitrite and sulphite reductase 4Fe-4S
CH556_RS09005	COG1373	ATPase (AAA superfamily
CH556_RS09010	COG0121	glutamine amidotransferase
CH556_RS09015	COG0762	integral membrane protein
CH556_RS09030	COG0560	Phosphoserine phosphatase
CH556_RS09040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH556_RS09050	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CH556_RS09055	COG1178	ABC-type Fe3 transport system permease component
CH556_RS09060	COG4143	(ABC) transporter
CH556_RS09065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH556_RS09075	COG2610	gluconate transmembrane transporter activity
CH556_RS09080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH556_RS09085	COG3622	Belongs to the hyi family
CH556_RS09090	COG0235	Class ii aldolase
CH556_RS09095	COG3395	kinase activity
CH556_RS09100	COG2084	Dehydrogenase
CH556_RS09105	COG1349	DNA-binding transcription factor activity
CH556_RS09110	COG1555	photosystem II stabilization
CH556_RS09125	COG2194	sulfuric ester hydrolase activity
CH556_RS09130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH556_RS09150	COG0594	ribonuclease P activity
CH556_RS09160	COG4783	chaperone-mediated protein folding
CH556_RS09170	COG4771	TonB-dependent receptor
CH556_RS09170	COG1629	transport