locus-tag	class	description
CH603_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH603_RS00010	COG0592	DNA-directed DNA polymerase activity
CH603_RS00030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH603_RS00035	COG0473	3-isopropylmalate dehydrogenase activity
CH603_RS00040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH603_RS00045	COG0758	DNA mediated transformation
CH603_RS00050	COG3022	response to hydroperoxide
CH603_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH603_RS00085	COG2184	nucleotidyltransferase activity
CH603_RS00090	COG0697	spore germination
CH603_RS00095	COG4145	pantothenate transmembrane transporter activity
CH603_RS00100	COG3924	membrane
CH603_RS00105	COG0439	Biotin carboxylase
CH603_RS00110	COG0511	ligase activity, forming carbon-carbon bonds
CH603_RS00120	COG1441	menaquinone biosynthetic process
CH603_RS00125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH603_RS00145	COG0728	peptidoglycan biosynthetic process
CH603_RS00150	COG0196	riboflavin kinase activity
CH603_RS00160	COG0537	adenosine 5'-monophosphoramidase activity
CH603_RS00165	COG5633	Lipoprotein
CH603_RS00170	COG1472	Belongs to the glycosyl hydrolase 3 family
CH603_RS00175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH603_RS00180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH603_RS00200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH603_RS00220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH603_RS00230	COG1487	ribonuclease activity
CH603_RS00235	COG0076	glutamate decarboxylase activity
CH603_RS00245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH603_RS00250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH603_RS00250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH603_RS00255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH603_RS00260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH603_RS00275	COG4795	General secretion pathway protein
CH603_RS00280	COG2165	general secretion pathway protein
CH603_RS00285	COG0483	inositol monophosphate 1-phosphatase activity
CH603_RS00290	COG1138	Cytochrome C-type biogenesis protein
CH603_RS00295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH603_RS00300	COG4235	cytochrome complex assembly
CH603_RS00300	COG3088	subunit of a heme lyase
CH603_RS00305	COG2081	HI0933 family
CH603_RS00315	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
CH603_RS00325	COG0754	glutathionylspermidine amidase activity
CH603_RS00330	COG0753	catalase activity
CH603_RS00340	COG4545	Glutaredoxin-related protein
CH603_RS00345	COG2852	Protein conserved in bacteria
CH603_RS00360	COG1466	dna polymerase III delta subunit
CH603_RS00365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH603_RS00375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH603_RS00380	COG0575	Belongs to the CDS family
CH603_RS00385	COG0750	zinc metalloprotease
CH603_RS00390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH603_RS00395	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH603_RS00415	COG2226	methyltransferase
CH603_RS00420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH603_RS00420	COG0475	glutathione-regulated potassium exporter activity
CH603_RS00425	COG0494	nUDIX hydrolase
CH603_RS00430	COG0653	protein targeting
CH603_RS00440	COG4701	Protein of unknown function (DUF721)
CH603_RS00445	COG0590	tRNA wobble adenosine to inosine editing
CH603_RS00455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH603_RS00460	COG0730	response to heat
CH603_RS00475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH603_RS00480	COG1566	PFAM secretion protein HlyD family protein
CH603_RS00485	COG2814	Major facilitator Superfamily
CH603_RS00490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH603_RS00495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH603_RS00500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH603_RS00505	COG1309	transcriptional regulator
CH603_RS00535	COG0151	Belongs to the GarS family
CH603_RS00540	COG0138	bifunctional purine biosynthesis protein purh
CH603_RS00545	COG2259	Doxx family
CH603_RS00555	COG0745	RESPONSE REGULATOR receiver
CH603_RS00560	COG1115	amino acid carrier protein
CH603_RS00565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH603_RS00570	COG0142	geranyltranstransferase activity
CH603_RS00595	COG0105	UTP biosynthetic process
CH603_RS00610	COG0174	glutamine synthetase
CH603_RS00620	COG1217	gtp-binding protein TYPA
CH603_RS00630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH603_RS00665	COG1120	ATPase activity
CH603_RS00685	COG0557	exoribonuclease II activity
CH603_RS00690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH603_RS00695	COG0542	response to heat
CH603_RS00700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH603_RS00715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH603_RS00715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH603_RS00725	COG0748	coenzyme F420 binding
CH603_RS00730	COG0747	negative chemotaxis
CH603_RS00735	COG2814	Major facilitator Superfamily
CH603_RS00740	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH603_RS00750	COG3086	response to oxidative stress
CH603_RS00760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH603_RS00765	COG3085	chromosome segregation
CH603_RS00770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH603_RS00775	COG3084	Protein conserved in bacteria
CH603_RS00785	COG0402	S-adenosylhomocysteine deaminase activity
CH603_RS00790	COG3083	sulfuric ester hydrolase activity
CH603_RS00805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH603_RS00810	COG0745	RESPONSE REGULATOR receiver
CH603_RS00820	COG1053	succinate dehydrogenase
CH603_RS00825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH603_RS00830	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH603_RS00835	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH603_RS00840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH603_RS00850	COG0741	lytic transglycosylase activity
CH603_RS00855	COG2350	Protein conserved in bacteria
CH603_RS00860	COG1607	acyl-coa hydrolase
CH603_RS00875	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH603_RS00880	COG1129	ABC transporter
CH603_RS00885	COG1879	ABC-type sugar transport system periplasmic component
CH603_RS00890	COG1609	Transcriptional regulator
CH603_RS00895	COG1085	galactose-1-phosphate uridylyltransferase
CH603_RS00900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH603_RS00905	COG2017	converts alpha-aldose to the beta-anomer
CH603_RS00915	COG0006	proline dipeptidase activity
CH603_RS00920	COG0589	response to stress
CH603_RS00935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH603_RS00965	COG0730	response to heat
CH603_RS00975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH603_RS01010	COG0201	protein transport
CH603_RS01095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH603_RS01115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH603_RS01120	COG0051	transcription antitermination factor activity, RNA binding
CH603_RS01125	COG0583	DNA-binding transcription factor activity
CH603_RS01130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CH603_RS01135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CH603_RS01140	COG2031	fatty acid transporter
CH603_RS01145	COG0183	Belongs to the thiolase family
CH603_RS01150	COG2177	Part of the ABC transporter FtsEX involved in
CH603_RS01155	COG2884	Cell division ATP-binding protein ftsE
CH603_RS01160	COG0552	protein localization to endoplasmic reticulum
CH603_RS01165	COG0742	ribosomal rna small subunit methyltransferase
CH603_RS01170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH603_RS01175	COG3306	glycosyltransferase involved in LPS biosynthesis
CH603_RS01185	COG3172	ATPase kinase involved in NAD metabolism
CH603_RS01190	COG2129	metallophosphoesterase
CH603_RS01215	COG1194	a g-specific adenine glycosylase
CH603_RS01230	COG4942	peptidase
CH603_RS01235	COG2861	carbohydrate metabolic process
CH603_RS01240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH603_RS01245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH603_RS01260	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH603_RS01265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH603_RS01280	COG1252	NADH dehydrogenase
CH603_RS01285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH603_RS01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH603_RS01295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH603_RS01300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH603_RS01305	COG0587	DNA-directed DNA polymerase activity
CH603_RS01310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH603_RS01320	COG0028	Belongs to the TPP enzyme family
CH603_RS01330	COG0733	neurotransmitter:sodium symporter activity
CH603_RS01345	COG0204	Acyl-transferase
CH603_RS01365	COG0514	ATP-dependent DNA helicase (RecQ)
CH603_RS01380	COG0019	diaminopimelate decarboxylase activity
CH603_RS01385	COG2197	response regulator
CH603_RS01425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH603_RS01440	COG1464	Belongs to the NlpA lipoprotein family
CH603_RS01445	COG1349	DNA-binding transcription factor activity
CH603_RS01450	COG0705	Rhomboid family
CH603_RS01455	COG0564	pseudouridine synthase activity
CH603_RS01465	COG1349	DNA-binding transcription factor activity
CH603_RS01470	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CH603_RS01475	COG1070	Carbohydrate kinase
CH603_RS01485	COG0235	Class ii aldolase
CH603_RS01490	COG0738	Major facilitator superfamily
CH603_RS01510	COG0471	metal ion transport
CH603_RS01515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH603_RS01520	COG1045	serine acetyltransferase
CH603_RS01530	COG3072	Adenylate cyclase
CH603_RS01535	COG2959	enzyme of heme biosynthesis
CH603_RS01540	COG3071	HemY protein
CH603_RS01590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH603_RS01595	COG1739	Uncharacterized protein family UPF0029
CH603_RS01610	COG0251	oxidation-reduction process
CH603_RS01615	COG2853	Lipoprotein
CH603_RS01620	COG0250	Participates in transcription elongation, termination and antitermination
CH603_RS01625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH603_RS01630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH603_RS01655	COG3276	selenocysteine insertion sequence binding
CH603_RS01660	COG1921	L-seryl-tRNASec selenium transferase activity
CH603_RS01670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH603_RS01675	COG0814	amino acid
CH603_RS01690	COG1388	LysM domain
CH603_RS01690	COG4942	peptidase
CH603_RS01700	COG1238	metal cluster binding
CH603_RS01715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH603_RS01720	COG1047	Peptidyl-prolyl cis-trans
CH603_RS01725	COG0729	surface antigen
CH603_RS01730	COG2911	Protein conserved in bacteria
CH603_RS01735	COG0248	Ppx GppA phosphatase
CH603_RS01740	COG1187	pseudouridine synthase activity
CH603_RS01745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CH603_RS01750	COG0584	glycerophosphoryl diester phosphodiesterase
CH603_RS01755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH603_RS01760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH603_RS01765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH603_RS01770	COG0584	glycerophosphoryl diester phosphodiesterase
CH603_RS01775	COG2271	Major facilitator Superfamily
CH603_RS01780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH603_RS01785	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH603_RS01790	COG0247	lactate metabolic process
CH603_RS01800	COG0583	DNA-binding transcription factor activity
CH603_RS01805	COG2962	Rard protein
CH603_RS01815	COG0149	triose-phosphate isomerase activity
CH603_RS01820	COG0456	acetyltransferase
CH603_RS01830	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH603_RS01855	COG1490	D-aminoacyl-tRNA deacylase activity
CH603_RS01860	COG0716	FMN binding
CH603_RS01870	COG1494	fructose-1,6-bisphosphatase
CH603_RS01880	COG3550	peptidyl-serine autophosphorylation
CH603_RS01885	COG3550	peptidyl-serine autophosphorylation
CH603_RS01890	COG1132	(ABC) transporter
CH603_RS01895	COG4988	ABC transporter
CH603_RS01910	COG0488	(ABC) transporter
CH603_RS01915	COG0551	DNA topoisomerase type I activity
CH603_RS01930	COG2818	Glycosylase
CH603_RS01935	COG0463	Glycosyl transferase, family 2
CH603_RS01940	COG1519	Transferase
CH603_RS01950	COG5645	(Lipo)protein
CH603_RS01955	COG0210	DNA helicase
CH603_RS01960	COG0583	DNA-binding transcription factor activity
CH603_RS01965	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH603_RS01970	COG1285	pathogenesis
CH603_RS01975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH603_RS01980	COG2267	carboxylic ester hydrolase activity
CH603_RS01985	COG3005	denitrification pathway
CH603_RS01990	COG0243	molybdopterin cofactor binding
CH603_RS02030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH603_RS02040	COG0180	Tryptophanyl-tRNA synthetase
CH603_RS02045	COG3691	Protein conserved in bacteria
CH603_RS02050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH603_RS02085	COG1072	(Pantothenic acid kinase))
CH603_RS02090	COG3026	antisigma factor binding
CH603_RS02095	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH603_RS02100	COG1595	DNA-templated transcription, initiation
CH603_RS02105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH603_RS02115	COG0569	domain protein
CH603_RS02120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH603_RS02120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH603_RS02165	COG3070	regulator of competence-specific genes
CH603_RS02185	COG0561	phosphatase activity
CH603_RS02190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH603_RS02195	COG0549	Belongs to the carbamate kinase family
CH603_RS02200	COG1288	antiporter activity
CH603_RS02230	COG3069	C4-dicarboxylate transmembrane transporter activity
CH603_RS02235	COG1473	amidohydrolase
CH603_RS02240	COG0737	Belongs to the 5'-nucleotidase family
CH603_RS02245	COG0789	Transcriptional regulator
CH603_RS02260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH603_RS02280	COG2168	tRNA wobble position uridine thiolation
CH603_RS02285	COG2923	Belongs to the DsrF TusC family
CH603_RS02290	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH603_RS02295	COG2964	Protein conserved in bacteria
CH603_RS02300	COG0545	Peptidyl-prolyl cis-trans isomerase
CH603_RS02310	COG0678	peroxiredoxin activity
CH603_RS02310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH603_RS02315	COG0583	DNA-binding transcription factor activity
CH603_RS02320	COG1309	transcriptional regulator
CH603_RS02325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH603_RS02330	COG2183	response to ionizing radiation
CH603_RS02335	COG0187	DNA topoisomerase II activity
CH603_RS02340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH603_RS02355	COG2801	Transposase and inactivated derivatives
CH603_RS02375	COG2801	Transposase and inactivated derivatives
CH603_RS02385	COG1522	sequence-specific DNA binding
CH603_RS02390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH603_RS02395	COG1297	OPT oligopeptide transporter protein
CH603_RS02405	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH603_RS02410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH603_RS02415	COG0363	glucosamine-6-phosphate deaminase activity
CH603_RS02420	COG1943	Transposase
CH603_RS02425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH603_RS02445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH603_RS02490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH603_RS02505	COG0804	urea catabolic process
CH603_RS02520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH603_RS02530	COG1027	Aspartate ammonia-lyase
CH603_RS02535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH603_RS02540	COG0358	DNA primase activity
CH603_RS02550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH603_RS02555	COG1435	thymidine kinase activity
CH603_RS02560	COG0814	amino acid
CH603_RS02565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH603_RS02570	COG3719	Belongs to the RNase T2 family
CH603_RS02580	COG0191	fructose-bisphosphate aldolase activity
CH603_RS02585	COG0859	PFAM glycosyl transferase family 9
CH603_RS02590	COG2364	Membrane
CH603_RS02595	COG1328	CTP reductase activity
CH603_RS02600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH603_RS02605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH603_RS02645	COG1275	C4-dicarboxylate transporter malic acid transport protein
CH603_RS02650	COG1720	tRNA m6t6A37 methyltransferase activity
CH603_RS02655	COG1575	Belongs to the MenA family. Type 1 subfamily
CH603_RS02670	COG1609	Transcriptional regulator
CH603_RS02675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH603_RS02680	COG1879	ABC-type sugar transport system periplasmic component
CH603_RS02685	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH603_RS02700	COG1322	Protein conserved in bacteria
CH603_RS02705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH603_RS02710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH603_RS02725	COG3700	Belongs to the class B bacterial acid phosphatase family
CH603_RS02740	COG1238	metal cluster binding
CH603_RS02745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH603_RS02760	COG3312	ion transport
CH603_RS02805	COG0814	amino acid
CH603_RS02815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH603_RS02815	COG0140	phosphoribosyl-ATP diphosphatase activity
CH603_RS02820	COG0107	imidazoleglycerol-phosphate synthase activity
CH603_RS02840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH603_RS02850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH603_RS02855	COG1561	YicC-like family, N-terminal region
CH603_RS02860	COG0354	folic acid binding
CH603_RS02865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH603_RS02870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH603_RS02875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH603_RS02880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH603_RS02885	COG2990	Protein conserved in bacteria
CH603_RS02890	COG3956	TIGRFAM MazG family protein
CH603_RS02900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH603_RS02905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH603_RS02925	COG0470	DNA polymerase III
CH603_RS02930	COG0084	hydrolase, TatD family'
CH603_RS02940	COG1253	flavin adenine dinucleotide binding
CH603_RS02950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH603_RS02950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH603_RS02955	COG1105	Belongs to the carbohydrate kinase PfkB family
CH603_RS02960	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH603_RS02960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH603_RS02960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH603_RS02970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH603_RS02975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH603_RS02985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH603_RS02990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH603_RS02995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH603_RS03000	COG4972	Pilus assembly protein
CH603_RS03005	COG3166	PFAM Fimbrial assembly family protein
CH603_RS03020	COG4796	Type ii and iii secretion system protein
CH603_RS03025	COG1040	competence protein
CH603_RS03040	COG3068	Protein conserved in bacteria
CH603_RS03045	COG0776	regulation of translation
CH603_RS03050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH603_RS03070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH603_RS03075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH603_RS03085	COG0513	Belongs to the DEAD box helicase family
CH603_RS03090	COG0826	peptidase U32
CH603_RS03095	COG0477	Major facilitator Superfamily
CH603_RS03105	COG0351	phosphomethylpyrimidine kinase
CH603_RS03115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH603_RS03120	COG1530	ribonuclease E activity
CH603_RS03125	COG0564	pseudouridine synthase activity
CH603_RS03130	COG1923	regulation of RNA biosynthetic process
CH603_RS03135	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CH603_RS03140	COG0739	heme binding
CH603_RS03150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH603_RS03155	COG0825	malonyl-CoA metabolic process
CH603_RS03160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CH603_RS03175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH603_RS03185	COG3691	Protein conserved in bacteria
CH603_RS03190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH603_RS03195	COG0494	nUDIX hydrolase
CH603_RS03205	COG2850	peptidyl-arginine hydroxylation
CH603_RS03220	COG0012	GTP binding
CH603_RS03230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH603_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
CH603_RS03240	COG3065	identical protein binding
CH603_RS03245	COG1214	PFAM Peptidase M22, glycoprotease
CH603_RS03250	COG1199	ATP-dependent helicase activity
CH603_RS03255	COG0824	Thioesterase
CH603_RS03260	COG0811	peptide transport
CH603_RS03265	COG0848	biopolymer transport protein
CH603_RS03270	COG3064	Membrane
CH603_RS03280	COG2885	chlorophyll binding
CH603_RS03295	COG0582	viral genome integration into host DNA
CH603_RS03460	COG3179	chitinase
CH603_RS03485	COG3728	DNA packaging
CH603_RS03490	COG1783	phage Terminase large subunit
CH603_RS03605	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH603_RS03620	COG4416	COG NOG18757 non supervised orthologous group
CH603_RS03625	COG3392	D12 class N6 adenine-specific DNA methyltransferase
CH603_RS03635	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH603_RS03640	COG1959	2 iron, 2 sulfur cluster binding
CH603_RS03650	COG0822	iron-sulfur transferase activity
CH603_RS03655	COG0316	Belongs to the HesB IscA family
CH603_RS03660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH603_RS03675	COG0633	Ferredoxin
CH603_RS03680	COG2975	iron-sulfur cluster assembly
CH603_RS03685	COG2976	Protein conserved in bacteria
CH603_RS03700	COG1426	Protein conserved in bacteria
CH603_RS03705	COG3063	Type IV pilus biogenesis stability protein PilW
CH603_RS03715	COG1686	Belongs to the peptidase S11 family
CH603_RS03725	COG1121	(ABC) transporter
CH603_RS03730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH603_RS03735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH603_RS03740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CH603_RS03745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH603_RS03750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH603_RS03755	COG1116	anion transmembrane transporter activity
CH603_RS03765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH603_RS03770	COG2814	Major facilitator Superfamily
CH603_RS03780	COG3005	denitrification pathway
CH603_RS03785	COG3043	anaerobic respiration
CH603_RS03790	COG0348	domain, Protein
CH603_RS03795	COG0437	4 iron, 4 sulfur cluster binding
CH603_RS03805	COG3062	negative regulation of establishment of protein localization
CH603_RS03810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH603_RS03815	COG3171	Protein conserved in bacteria
CH603_RS03825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH603_RS03830	COG0628	permease
CH603_RS03835	COG0347	Belongs to the P(II) protein family
CH603_RS03840	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH603_RS03845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH603_RS03850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH603_RS03855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH603_RS03860	COG1381	Involved in DNA repair and RecF pathway recombination
CH603_RS03870	COG3266	domain, Protein
CH603_RS03870	COG3061	Opacity-associated protein A
CH603_RS03875	COG1509	lysine 2,3-aminomutase activity
CH603_RS03895	COG2056	Na+-H+ antiporter family
CH603_RS03905	COG0346	lactoylglutathione lyase activity
CH603_RS03925	COG1755	Isoprenylcysteine carboxyl methyltransferase
CH603_RS03940	COG3392	D12 class N6 adenine-specific DNA methyltransferase
CH603_RS03950	COG2801	Transposase and inactivated derivatives
CH603_RS03965	COG0494	nUDIX hydrolase
CH603_RS03995	COG4974	Belongs to the 'phage' integrase family
CH603_RS04000	COG2814	Major facilitator Superfamily
CH603_RS04005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH603_RS04025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH603_RS04030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH603_RS04035	COG4535	Mg2 and Co2 transporter CorC
CH603_RS04040	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH603_RS04045	COG4969	Belongs to the N-Me-Phe pilin family
CH603_RS04050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH603_RS04055	COG1459	type II secretion system
CH603_RS04060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH603_RS04065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH603_RS04075	COG0789	Transcriptional regulator
CH603_RS04080	COG2608	mercury ion transmembrane transporter activity
CH603_RS04090	COG2608	mercury ion transmembrane transporter activity
CH603_RS04095	COG2217	Heavy metal translocating P-type atpase
CH603_RS04100	COG0814	amino acid
CH603_RS04105	COG1760	l-serine dehydratase
CH603_RS04110	COG0814	amino acid
CH603_RS04115	COG0436	Aminotransferase
CH603_RS04125	COG1169	isochorismate synthase
CH603_RS04135	COG2267	carboxylic ester hydrolase activity
CH603_RS04140	COG0477	Major facilitator Superfamily
CH603_RS04145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH603_RS04150	COG2258	MOSC domain
CH603_RS04165	COG1368	sulfuric ester hydrolase activity
CH603_RS04210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH603_RS04220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH603_RS04230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH603_RS04235	COG3850	Histidine kinase
CH603_RS04245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH603_RS04265	COG0859	PFAM glycosyl transferase family 9
CH603_RS04275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH603_RS04285	COG1442	glycosyl transferase family 8
CH603_RS04300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH603_RS04305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH603_RS04315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH603_RS04320	COG0811	peptide transport
CH603_RS04325	COG0848	biopolymer transport protein
CH603_RS04330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH603_RS04335	COG0629	single-stranded DNA binding
CH603_RS04340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH603_RS04350	COG0641	radical SAM
CH603_RS04360	COG0343	queuine tRNA-ribosyltransferase activity
CH603_RS04365	COG3945	hemerythrin HHE cation binding domain
CH603_RS04370	COG0425	Belongs to the sulfur carrier protein TusA family
CH603_RS04375	COG1862	Preprotein translocase
CH603_RS04380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH603_RS04385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH603_RS04395	COG1393	Belongs to the ArsC family
CH603_RS04400	COG3036	rescue of stalled ribosome
CH603_RS04415	COG0513	Belongs to the DEAD box helicase family
CH603_RS04420	COG4785	May be involved in cell division
CH603_RS04435	COG2731	YhcH YjgK YiaL family protein
CH603_RS04440	COG1114	Component of the transport system for branched-chain amino acids
CH603_RS04450	COG1522	sequence-specific DNA binding
CH603_RS04455	COG2962	Rard protein
CH603_RS04465	COG0517	IMP dehydrogenase activity
CH603_RS04465	COG0516	GMP reductase activity
CH603_RS04470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH603_RS04470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH603_RS04495	COG1573	uracil-dna glycosylase
CH603_RS04505	COG3059	membrane
CH603_RS04535	COG0339	signal peptide processing
CH603_RS04540	COG2832	Protein of unknown function (DUF454)
CH603_RS04545	COG4166	transmembrane transport
CH603_RS04555	COG0671	phosphoesterase, PA-phosphatase related
CH603_RS04560	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CH603_RS04575	COG0737	Belongs to the 5'-nucleotidase family
CH603_RS04610	COG1560	Kdo2-lipid A biosynthetic process
CH603_RS04615	COG0730	response to heat
CH603_RS04620	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH603_RS04630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH603_RS04630	COG3264	Mechanosensitive ion channel
CH603_RS04635	COG0318	PFAM AMP-dependent synthetase and ligase
CH603_RS04640	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH603_RS04645	COG0596	Alpha beta hydrolase
CH603_RS04650	COG0716	FMN binding
CH603_RS04655	COG0735	belongs to the Fur family
CH603_RS04660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CH603_RS04665	COG0805	protein transport
CH603_RS04680	COG0789	Transcriptional regulator
CH603_RS04685	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CH603_RS04690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CH603_RS04695	COG1115	amino acid carrier protein
CH603_RS04705	COG2116	formate transmembrane transporter activity
CH603_RS04710	COG1882	Formate acetyltransferase
CH603_RS04715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH603_RS04725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH603_RS04730	COG0564	pseudouridine synthase activity
CH603_RS04735	COG1496	oxidoreductase activity
CH603_RS04745	COG2991	Protein conserved in bacteria
CH603_RS04750	COG1477	protein flavinylation
CH603_RS04770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH603_RS04790	COG3056	Lipoprotein
CH603_RS04795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH603_RS04800	COG0688	phosphatidylethanolamine metabolic process
CH603_RS04805	COG1399	metal-binding, possibly nucleic acid-binding protein
CH603_RS04825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH603_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
CH603_RS04840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH603_RS04845	COG2091	lysine biosynthetic process via aminoadipic acid
CH603_RS04850	COG0330	HflC and HflK could
CH603_RS04855	COG0330	HflC and HflK could
CH603_RS04860	COG2020	methyltransferase activity
CH603_RS04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CH603_RS04870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CH603_RS04880	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CH603_RS04890	COG1737	Transcriptional regulator
CH603_RS04895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH603_RS04905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH603_RS04920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH603_RS04935	COG1160	GTP binding
CH603_RS04960	COG2252	PERMEase
CH603_RS04965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH603_RS04985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH603_RS04995	COG0626	cystathionine gamma-synthase activity
CH603_RS05000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH603_RS05005	COG5413	integral membrane protein
CH603_RS05010	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH603_RS05015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH603_RS05020	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH603_RS05070	COG1629	transport
CH603_RS05080	COG0625	glutathione transferase activity
CH603_RS05085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH603_RS05100	COG2841	Protein conserved in bacteria
CH603_RS05105	COG3610	response to peptide
CH603_RS05110	COG3610	response to peptide
CH603_RS05115	COG4536	flavin adenine dinucleotide binding
CH603_RS05120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH603_RS05140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CH603_RS05145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH603_RS05150	COG0326	Molecular chaperone. Has ATPase activity
CH603_RS05155	COG1393	Belongs to the ArsC family
CH603_RS05165	COG1876	peptidase activity
CH603_RS05175	COG1178	ABC-type Fe3 transport system permease component
CH603_RS05180	COG1840	ABC-type Fe3 transport system, periplasmic component
CH603_RS05185	COG4797	methyltransferase
CH603_RS05190	COG2226	methyltransferase
CH603_RS05200	COG2610	gluconate transmembrane transporter activity
CH603_RS05200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH603_RS05205	COG3835	regulator
CH603_RS05210	COG2610	gluconate transmembrane transporter activity
CH603_RS05215	COG1929	Belongs to the glycerate kinase type-1 family
CH603_RS05220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH603_RS05225	COG0460	homoserine dehydrogenase
CH603_RS05225	COG0527	aspartate kinase activity
CH603_RS05235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CH603_RS05260	COG0626	cystathionine gamma-synthase activity
CH603_RS05265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH603_RS05270	COG3118	belongs to the thioredoxin family
CH603_RS05280	COG0084	hydrolase, TatD family'
CH603_RS05285	COG3692	DNA binding
CH603_RS05290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH603_RS05300	COG1946	Acyl-CoA thioesterase
CH603_RS05305	COG1328	CTP reductase activity
CH603_RS05305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH603_RS05310	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CH603_RS05315	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CH603_RS05320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH603_RS05330	COG0497	DNA recombination
CH603_RS05335	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH603_RS05340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH603_RS05350	COG1388	LysM domain
CH603_RS05350	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH603_RS05355	COG0802	atpase or kinase
CH603_RS05360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH603_RS05365	COG0617	tRNA 3'-terminal CCA addition
CH603_RS05370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH603_RS05375	COG2333	competence protein COMEC
CH603_RS05375	COG0658	competence protein
CH603_RS05380	COG1132	(ABC) transporter
CH603_RS05385	COG1663	tetraacyldisaccharide 4'-kinase activity
CH603_RS05400	COG0861	Integral membrane protein TerC family
CH603_RS05410	COG2186	Transcriptional regulator
CH603_RS05415	COG1063	alcohol dehydrogenase
CH603_RS05420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH603_RS05425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CH603_RS05430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CH603_RS05435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH603_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
CH603_RS05445	COG0800	Aldolase
CH603_RS05450	COG2824	Alkylphosphonate utilization operon protein PhnA
CH603_RS05455	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH603_RS05465	COG0670	Belongs to the BI1 family
CH603_RS05475	COG0564	pseudouridine synthase activity
CH603_RS05480	COG0708	Exodeoxyribonuclease III
CH603_RS05485	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH603_RS05490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH603_RS05495	COG1792	Involved in formation and maintenance of cell shape
CH603_RS05500	COG1077	Cell shape determining protein MreB Mrl
CH603_RS05505	COG4178	(ABC) transporter
CH603_RS05515	COG0799	negative regulation of ribosome biogenesis
CH603_RS05525	COG0768	penicillin binding
CH603_RS05530	COG0772	Belongs to the SEDS family
CH603_RS05535	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH603_RS05535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH603_RS05540	COG1686	Belongs to the peptidase S11 family
CH603_RS05560	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH603_RS05570	COG2301	Belongs to the HpcH HpaI aldolase family
CH603_RS05575	COG3051	citrate lyase alpha subunit
CH603_RS05580	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH603_RS05580	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH603_RS05585	COG0471	metal ion transport
CH603_RS05610	COG0681	Belongs to the peptidase S26 family
CH603_RS05630	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH603_RS05635	COG0456	acetyltransferase
CH603_RS05645	COG2864	formate dehydrogenase
CH603_RS05650	COG0437	4 iron, 4 sulfur cluster binding
CH603_RS05675	COG0561	phosphatase activity
CH603_RS05680	COG1022	Amp-dependent synthetase and ligase
CH603_RS05685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH603_RS05695	COG1758	RNA polymerase activity
CH603_RS05700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH603_RS05705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH603_RS05745	COG0583	DNA-binding transcription factor activity
CH603_RS05750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH603_RS05755	COG1687	branched-chain amino acid
CH603_RS05770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH603_RS05780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH603_RS05785	COG1984	allophanate hydrolase subunit 2
CH603_RS05795	COG1914	H( )-stimulated, divalent metal cation uptake system
CH603_RS05810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH603_RS05815	COG3112	Uncharacterised protein family (UPF0231)
CH603_RS05825	COG0024	Methionine aminopeptidase
CH603_RS05835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH603_RS05860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH603_RS05865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH603_RS05870	COG2190	(PTS) system
CH603_RS05880	COG3111	PFAM Bacterial OB fold (BOF) protein
CH603_RS05885	COG0745	RESPONSE REGULATOR receiver
CH603_RS05890	COG0642	Histidine kinase
CH603_RS05895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH603_RS05905	COG0795	lipopolysaccharide-transporting ATPase activity
CH603_RS05910	COG0795	lipopolysaccharide-transporting ATPase activity
CH603_RS05920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH603_RS05925	COG2244	polysaccharide biosynthetic process
CH603_RS05935	COG0438	transferase activity, transferring glycosyl groups
CH603_RS05940	COG3306	glycosyltransferase involved in LPS biosynthesis
CH603_RS05945	COG1216	Glycosyl transferase, family 2
CH603_RS05950	COG1216	Glycosyl transferase, family 2
CH603_RS05955	COG2005	Transcriptional regulator
CH603_RS05960	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH603_RS05965	COG4149	molybdate abc transporter
CH603_RS05975	COG0733	neurotransmitter:sodium symporter activity
CH603_RS05980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH603_RS06015	COG0616	signal peptide processing
CH603_RS06025	COG1289	transmembrane transporter activity
CH603_RS06030	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH603_RS06045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH603_RS06050	COG0517	IMP dehydrogenase activity
CH603_RS06050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH603_RS06060	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CH603_RS06075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH603_RS06080	COG0314	molybdopterin synthase activity
CH603_RS06085	COG3008	intermembrane lipid transfer
CH603_RS06090	COG2995	paraquat-inducible protein a
CH603_RS06100	COG0793	Belongs to the peptidase S41A family
CH603_RS06105	COG2989	Protein conserved in bacteria
CH603_RS06110	COG3108	Peptidase M15
CH603_RS06115	COG0084	hydrolase, TatD family'
CH603_RS06120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH603_RS06125	COG0567	Dehydrogenase, E1 component
CH603_RS06130	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH603_RS06135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH603_RS06140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH603_RS06145	COG2823	Periplasmic or secreted lipoprotein
CH603_RS06150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH603_RS06160	COG3107	peptidoglycan biosynthetic process
CH603_RS06165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH603_RS06175	COG0791	NLP P60 protein
CH603_RS06195	COG0277	FAD linked oxidase domain protein
CH603_RS06210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH603_RS06215	COG0539	negative regulation of cytoplasmic translation
CH603_RS06225	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH603_RS06230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH603_RS06240	COG0023	Translation Initiation Factor
CH603_RS06245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH603_RS06250	COG2233	PERMEase
CH603_RS06260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH603_RS06270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH603_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH603_RS06280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH603_RS06290	COG5339	Protein conserved in bacteria
CH603_RS06295	COG0443	Heat shock 70 kDa protein
CH603_RS06310	COG2860	membrane
CH603_RS06320	COG2814	Major facilitator Superfamily
CH603_RS06325	COG1187	pseudouridine synthase activity
CH603_RS06330	COG3955	Domain of unknown function (DUF1919)
CH603_RS06335	COG0280	phosphate acetyltransferase
CH603_RS06335	COG0281	malic enzyme
CH603_RS06340	COG1368	sulfuric ester hydrolase activity
CH603_RS06355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH603_RS06360	COG3683	transport system, periplasmic component
CH603_RS06365	COG3549	Plasmid maintenance system killer
CH603_RS06370	COG3093	addiction module antidote protein HigA
CH603_RS06375	COG0488	(ABC) transporter
CH603_RS06380	COG3094	Invasion gene expression up-regulator, SirB
CH603_RS06385	COG1444	tRNA N-acetyltransferase activity
CH603_RS06390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH603_RS06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH603_RS06405	COG0285	dihydrofolate synthase activity
CH603_RS06410	COG2949	membrane
CH603_RS06420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH603_RS06425	COG1944	ATP diphosphatase activity
CH603_RS06435	COG0500	methyltransferase
CH603_RS06455	COG0489	protein tyrosine kinase activity
CH603_RS06460	COG0778	Nitroreductase
CH603_RS06465	COG1083	cytidylyl-transferase
CH603_RS06470	COG4695	Portal protein
CH603_RS06510	COG3772	lysozyme
CH603_RS06610	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH603_RS06760	COG0195	Participates in both transcription termination and antitermination
CH603_RS06765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH603_RS06770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CH603_RS06780	COG0732	type I restriction modification DNA specificity domain
CH603_RS06785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CH603_RS06805	COG0287	Prephenate dehydrogenase
CH603_RS06805	COG1605	Chorismate mutase
CH603_RS06815	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CH603_RS06820	COG2166	iron-sulfur cluster assembly
CH603_RS06825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH603_RS06830	COG1525	nuclease
CH603_RS06840	COG1346	cytolysis
CH603_RS06850	COG0488	(ABC) transporter
CH603_RS06855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH603_RS06860	COG1177	transmembrane transport
CH603_RS06865	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH603_RS06870	COG3842	ATPase activity
CH603_RS06880	COG0783	Belongs to the Dps family
CH603_RS06895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH603_RS06900	COG1530	ribonuclease E activity
CH603_RS06915	COG1640	4-alpha-glucanotransferase
CH603_RS06925	COG1523	belongs to the glycosyl hydrolase 13 family
CH603_RS06935	COG0297	glycogen (starch) synthase activity
CH603_RS06940	COG0058	SHG alpha-glucan phosphorylase activity
CH603_RS06945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH603_RS06950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH603_RS06955	COG0583	DNA-binding transcription factor activity
CH603_RS06960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH603_RS06975	COG0612	Peptidase, M16
CH603_RS06980	COG4771	TonB-dependent receptor
CH603_RS06985	COG3585	molybdate ion transport
CH603_RS06990	COG2920	part of a sulfur-relay system
CH603_RS06995	COG0037	tRNA processing
CH603_RS07000	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH603_RS07015	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH603_RS07025	COG3586	endonuclease activity
CH603_RS07030	COG0697	spore germination
CH603_RS07035	COG2925	Exonuclease
CH603_RS07040	COG5002	protein histidine kinase activity
CH603_RS07045	COG0745	RESPONSE REGULATOR receiver
CH603_RS07055	COG0581	inorganic phosphate transmembrane transporter activity
CH603_RS07060	COG0573	inorganic phosphate transmembrane transporter activity
CH603_RS07065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH603_RS07070	COG1528	Iron-storage protein
CH603_RS07075	COG1528	Iron-storage protein
CH603_RS07085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH603_RS07090	COG0512	Glutamine amidotransferase of anthranilate synthase
CH603_RS07095	COG1942	4-Oxalocrotonate Tautomerase
CH603_RS07105	COG0134	indole-3-glycerol-phosphate synthase activity
CH603_RS07105	COG0135	phosphoribosylanthranilate isomerase activity
CH603_RS07110	COG0298	carbon dioxide binding
CH603_RS07120	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CH603_RS07130	COG3097	Belongs to the UPF0267 family
CH603_RS07140	COG4185	zeta toxin
CH603_RS07145	COG2927	DNA polymerase III (CHI subunit)
CH603_RS07150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH603_RS07160	COG0114	fumarate hydratase activity
CH603_RS07165	COG2268	Band 7 protein
CH603_RS07170	COG0613	PHP domain protein
CH603_RS07180	COG3566	protein conserved in bacteria
CH603_RS07185	COG2369	cell adhesion
CH603_RS07190	COG3567	Phage-associated protein, HI1409 family
CH603_RS07200	COG3728	DNA packaging
CH603_RS07345	COG3723	Recombinational DNA repair protein, rece pathway
CH603_RS07370	COG2974	May be involved in recombination
CH603_RS07430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH603_RS07435	COG0589	response to stress
CH603_RS07440	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CH603_RS07445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH603_RS07450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH603_RS07455	COG4221	oxidoreductase activity
CH603_RS07465	COG0159	tryptophan synthase activity
CH603_RS07470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH603_RS07475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH603_RS07480	COG1278	Cold shock
CH603_RS07490	COG0564	pseudouridine synthase activity
CH603_RS07495	COG3098	single-species biofilm formation
CH603_RS07510	COG0142	geranyltranstransferase activity
CH603_RS07520	COG2969	positive regulation of protein catabolic process
CH603_RS07525	COG0625	glutathione transferase activity
CH603_RS07540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CH603_RS07545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH603_RS07550	COG3100	YcgL domain-containing protein
CH603_RS07555	COG0302	gtp cyclohydrolase
CH603_RS07560	COG0303	'Molybdopterin
CH603_RS07565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH603_RS07570	COG3099	Belongs to the UPF0263 family
CH603_RS07575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH603_RS07580	COG0785	Cytochrome C biogenesis protein
CH603_RS07585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH603_RS07585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH603_RS07600	COG1595	DNA-templated transcription, initiation
CH603_RS07615	COG1538	Outer membrane efflux protein
CH603_RS07625	COG2062	phosphohistidine phosphatase, SixA
CH603_RS07635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH603_RS07640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH603_RS07645	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH603_RS07650	COG1534	Rna-binding protein
CH603_RS07655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH603_RS07660	COG2027	D-alanyl-D-alanine carboxypeptidase
CH603_RS07680	COG0515	serine threonine protein kinase
CH603_RS07690	COG1067	ATP-dependent peptidase activity
CH603_RS07700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH603_RS07705	COG1074	ATP-dependent DNA helicase activity
CH603_RS07710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CH603_RS07715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH603_RS07725	COG0676	glucose-6-phosphate 1-epimerase activity
CH603_RS07730	COG3119	arylsulfatase activity
CH603_RS07735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH603_RS07745	COG0631	protein serine/threonine phosphatase activity
CH603_RS07750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH603_RS07755	COG1674	ftsk spoiiie
CH603_RS07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH603_RS07770	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CH603_RS07780	COG0791	NLP P60 protein
CH603_RS07785	COG0776	regulation of translation
CH603_RS07795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH603_RS07805	COG0633	Ferredoxin
CH603_RS07815	COG1280	lysine exporter protein (LysE YggA)
CH603_RS07820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH603_RS07825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH603_RS07845	COG0288	reversible hydration of carbon dioxide
CH603_RS07850	COG0488	(ABC) transporter
CH603_RS07860	COG0488	(ABC) transporter
CH603_RS07880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH603_RS07880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH603_RS07885	COG1560	Kdo2-lipid A biosynthetic process
CH603_RS07890	COG0187	DNA topoisomerase II activity
CH603_RS07895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH603_RS07900	COG0786	glutamate:sodium symporter activity
CH603_RS07910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH603_RS07915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH603_RS07930	COG0510	thiamine kinase activity
CH603_RS07935	COG0697	spore germination
CH603_RS07945	COG3475	LICD family
CH603_RS07955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH603_RS07955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH603_RS07965	COG0697	spore germination
CH603_RS07970	COG4750	Nucleotidyl transferase
CH603_RS07975	COG3475	LICD family
CH603_RS07980	COG0616	signal peptide processing
CH603_RS07985	COG0778	Nitroreductase
CH603_RS07990	COG3381	protein complex oligomerization
CH603_RS07995	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH603_RS08005	COG2932	Transcriptional regulator
CH603_RS08010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH603_RS08015	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH603_RS08020	COG1136	(ABC) transporter
CH603_RS08025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH603_RS08030	COG0500	methyltransferase
CH603_RS08035	COG2830	Protein of unknown function (DUF452)
CH603_RS08045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CH603_RS08050	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH603_RS08055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH603_RS08065	COG2912	Transglutaminase-like superfamily
CH603_RS08070	COG2890	protein-(glutamine-N5) methyltransferase activity
CH603_RS08075	COG1714	RDD family
CH603_RS08095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CH603_RS08100	COG3101	peptidyl-lysine hydroxylation
CH603_RS08105	COG2369	cell adhesion
CH603_RS08110	COG4383	Mu-like prophage protein gp29
CH603_RS08130	COG0469	pyruvate kinase activity
CH603_RS08135	COG0305	Participates in initiation and elongation during chromosome replication
CH603_RS08140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH603_RS08155	COG1216	Glycosyl transferase, family 2
CH603_RS08160	COG3133	Outer membrane lipoprotein
CH603_RS08170	COG3102	Protein conserved in bacteria
CH603_RS08175	COG0018	arginyl-trna synthetase
CH603_RS08180	COG0440	acetolactate synthase activity
CH603_RS08185	COG0028	Belongs to the TPP enzyme family
CH603_RS08195	COG1757	Na H antiporter
CH603_RS08200	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH603_RS08205	COG0788	formyltetrahydrofolate deformylase activity
CH603_RS08215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH603_RS08225	COG1674	ftsk spoiiie
CH603_RS08230	COG1522	sequence-specific DNA binding
CH603_RS08235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CH603_RS08240	COG3025	triphosphatase activity
CH603_RS08255	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH603_RS08275	COG3219	Protein conserved in bacteria
CH603_RS08290	COG2259	Doxx family
CH603_RS08295	COG1392	Phosphate transport regulator
CH603_RS08300	COG0306	phosphate transporter
CH603_RS08305	COG4991	sh3 domain protein
CH603_RS08325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH603_RS08340	COG0534	Mate efflux family protein
CH603_RS08345	COG0307	riboflavin synthase, alpha
CH603_RS08350	COG0308	aminopeptidase N
CH603_RS08365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH603_RS08370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH603_RS08375	COG1448	Aminotransferase
CH603_RS08380	COG1122	ATPase activity
CH603_RS08385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CH603_RS08390	COG0310	cobalt ion transport
CH603_RS08395	COG0310	cobalt ion transport
CH603_RS08400	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CH603_RS08405	COG0789	Transcriptional regulator
CH603_RS08410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CH603_RS08420	COG0251	oxidation-reduction process
CH603_RS08425	COG3105	Protein conserved in bacteria
CH603_RS08460	COG0527	aspartate kinase activity
CH603_RS08480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH603_RS08485	COG3106	COG3106 Predicted ATPase
CH603_RS08490	COG4166	transmembrane transport
CH603_RS08495	COG4168	peptide transport system, permease
CH603_RS08500	COG4171	peptide transport system, permease
CH603_RS08505	COG4172	Belongs to the ABC transporter superfamily
CH603_RS08510	COG4172	Belongs to the ABC transporter superfamily
CH603_RS08515	COG2855	membrane
CH603_RS08535	COG1620	l-lactate permease
CH603_RS08540	COG4206	TonB-dependent receptor
CH603_RS08540	COG1629	transport
CH603_RS08545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH603_RS08550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH603_RS08555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH603_RS08560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH603_RS08585	COG1090	epimerase
CH603_RS08590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH603_RS08595	COG1286	toxin biosynthetic process
CH603_RS08600	COG3092	negative regulation of chromosome organization
CH603_RS08610	COG0857	belongs to the CobB CobQ family
CH603_RS08610	COG0280	phosphate acetyltransferase
CH603_RS08615	COG2840	Smr protein MutS2
CH603_RS08620	COG2890	protein-(glutamine-N5) methyltransferase activity
CH603_RS08625	COG0583	DNA-binding transcription factor activity
CH603_RS08630	COG1187	pseudouridine synthase activity
CH603_RS08635	COG0009	L-threonylcarbamoyladenylate synthase
CH603_RS08640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH603_RS08655	COG0583	DNA-binding transcription factor activity
CH603_RS08660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH603_RS08675	COG0720	synthase
CH603_RS08680	COG0602	queuosine metabolic process
CH603_RS08690	COG0210	DNA helicase
CH603_RS08695	COG0601	transmembrane transport
CH603_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH603_RS08705	COG0444	Belongs to the ABC transporter superfamily
CH603_RS08710	COG4608	Belongs to the ABC transporter superfamily
CH603_RS08715	COG1793	dna ligase
CH603_RS08725	COG1126	abc transporter atp-binding protein
CH603_RS08730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH603_RS08735	COG4215	(ABC) transporter
CH603_RS08740	COG4160	amino acid transport
CH603_RS08750	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH603_RS08755	COG3091	SprT-like family
CH603_RS08765	COG0512	Glutamine amidotransferase of anthranilate synthase
CH603_RS08770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH603_RS08775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH603_RS08785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH603_RS08805	COG0247	lactate metabolic process
CH603_RS08805	COG0277	FAD linked oxidase domain protein
CH603_RS08810	COG2050	protein possibly involved in aromatic compounds catabolism
CH603_RS08820	COG3118	belongs to the thioredoxin family
CH603_RS08825	COG0492	ferredoxin-NADP+ reductase activity
CH603_RS08830	COG4988	ABC transporter
CH603_RS08835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH603_RS08845	COG0602	queuosine metabolic process
CH603_RS08850	COG1823	symporter activity
CH603_RS08860	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH603_RS08865	COG0312	modulator of DNA gyrase
CH603_RS08875	COG3117	lipopolysaccharide transmembrane transporter activity
CH603_RS08880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH603_RS08885	COG1137	ATPase activity
CH603_RS08890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH603_RS08895	COG1660	Displays ATPase and GTPase activities
CH603_RS08900	COG0077	Prephenate dehydratase
CH603_RS08900	COG1605	Chorismate mutase
CH603_RS08910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH603_RS08915	COG0849	cell division
CH603_RS08920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH603_RS08925	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH603_RS08930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH603_RS08940	COG0772	Belongs to the SEDS family
CH603_RS08955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH603_RS08965	COG0768	penicillin binding
CH603_RS08970	COG3116	cell division
CH603_RS08985	COG1966	Carbon starvation protein
CH603_RS09000	COG4166	transmembrane transport
CH603_RS09005	COG0601	transmembrane transport
CH603_RS09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH603_RS09015	COG0444	Belongs to the ABC transporter superfamily
CH603_RS09020	COG4608	Belongs to the ABC transporter superfamily
CH603_RS09025	COG2990	Protein conserved in bacteria
CH603_RS09035	COG0606	chelatase, subunit chli
CH603_RS09045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH603_RS09055	COG1070	Carbohydrate kinase
CH603_RS09065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH603_RS09070	COG1757	Na H antiporter
CH603_RS09075	COG2207	Transcriptional regulator
CH603_RS09075	COG1609	Transcriptional regulator
CH603_RS09080	COG0859	PFAM glycosyl transferase family 9
CH603_RS09085	COG2814	Major facilitator Superfamily
CH603_RS09090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH603_RS09105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH603_RS09130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH603_RS09135	COG1138	Cytochrome C-type biogenesis protein
CH603_RS09140	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH603_RS09145	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH603_RS09150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH603_RS09155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH603_RS09160	COG4133	protoheme IX ABC transporter activity
CH603_RS09165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH603_RS09170	COG1127	ABC transporter
CH603_RS09175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH603_RS09180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH603_RS09185	COG2854	intermembrane phospholipid transfer
CH603_RS09190	COG3113	response to antibiotic
CH603_RS09195	COG5007	Belongs to the BolA IbaG family
CH603_RS09205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH603_RS09210	COG0765	amino acid transport
CH603_RS09215	COG1126	abc transporter atp-binding protein
CH603_RS09220	COG3201	nicotinamide mononucleotide transporter
CH603_RS09230	COG1271	oxidase subunit
CH603_RS09235	COG1294	oxidase, subunit
CH603_RS09245	COG2363	Small membrane protein
CH603_RS09250	COG1643	Atp-dependent helicase
CH603_RS09255	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH603_RS09260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH603_RS09265	COG0437	4 iron, 4 sulfur cluster binding
CH603_RS09270	COG3301	Polysulphide reductase, NrfD
CH603_RS09280	COG2194	sulfuric ester hydrolase activity
CH603_RS09295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH603_RS09305	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CH603_RS09310	COG3421	Type III restriction
CH603_RS09315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH603_RS09320	COG4977	sequence-specific DNA binding
CH603_RS09320	COG1917	Cupin 2, conserved barrel domain protein
CH603_RS09325	COG1132	(ABC) transporter
CH603_RS09330	COG2608	mercury ion transmembrane transporter activity
CH603_RS09340	COG1305	Transglutaminase-like
CH603_RS09345	COG0243	molybdopterin cofactor binding
CH603_RS09355	COG3302	dmso reductase anchor subunit
CH603_RS09360	COG3381	protein complex oligomerization
CH603_RS09365	COG2221	Nitrite and sulphite reductase 4Fe-4S
CH603_RS09365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH603_RS09385	COG1373	ATPase (AAA superfamily
CH603_RS09390	COG0121	glutamine amidotransferase
CH603_RS09395	COG0762	integral membrane protein
CH603_RS09410	COG0560	Phosphoserine phosphatase
CH603_RS09415	COG1414	Transcriptional regulator
CH603_RS09420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CH603_RS09425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CH603_RS09430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CH603_RS09435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH603_RS09440	COG1070	Carbohydrate kinase
CH603_RS09445	COG3623	hexulose-6-phosphate isomerase
CH603_RS09450	COG0235	Class ii aldolase
CH603_RS09455	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CH603_RS09460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH603_RS09470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CH603_RS09475	COG1178	ABC-type Fe3 transport system permease component
CH603_RS09480	COG4143	(ABC) transporter
CH603_RS09485	COG1555	photosystem II stabilization
CH603_RS09500	COG2194	sulfuric ester hydrolase activity
CH603_RS09505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH603_RS09510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH603_RS09545	COG4771	TonB-dependent receptor
CH603_RS09545	COG1629	transport