locus-tag	class	description
R2866_RS00015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
R2866_RS00035	COG2168	tRNA wobble position uridine thiolation
R2866_RS00040	COG2923	Belongs to the DsrF TusC family
R2866_RS00045	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
R2866_RS00050	COG2964	Protein conserved in bacteria
R2866_RS00055	COG0545	Peptidyl-prolyl cis-trans isomerase
R2866_RS00065	COG0678	peroxiredoxin activity
R2866_RS00065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
R2866_RS00070	COG0583	DNA-binding transcription factor activity
R2866_RS00075	COG1309	transcriptional regulator
R2866_RS00080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
R2866_RS00085	COG2183	response to ionizing radiation
R2866_RS00090	COG0187	DNA topoisomerase II activity
R2866_RS00095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
R2866_RS00100	COG0546	phosphoglycolate phosphatase activity
R2866_RS00105	COG2502	aspartate--ammonia ligase
R2866_RS00110	COG1522	sequence-specific DNA binding
R2866_RS00115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
R2866_RS00120	COG1297	OPT oligopeptide transporter protein
R2866_RS00130	COG1218	3'(2'),5'-bisphosphate nucleotidase
R2866_RS00135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
R2866_RS00140	COG0363	glucosamine-6-phosphate deaminase activity
R2866_RS00155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
R2866_RS00165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
R2866_RS00170	COG3306	glycosyltransferase involved in LPS biosynthesis
R2866_RS00215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
R2866_RS00220	COG1027	Aspartate ammonia-lyase
R2866_RS00225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
R2866_RS00230	COG0358	DNA primase activity
R2866_RS00240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
R2866_RS00245	COG1435	thymidine kinase activity
R2866_RS00250	COG0814	amino acid
R2866_RS00255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
R2866_RS00260	COG3719	Belongs to the RNase T2 family
R2866_RS00270	COG0191	fructose-bisphosphate aldolase activity
R2866_RS00275	COG0859	PFAM glycosyl transferase family 9
R2866_RS00280	COG2364	Membrane
R2866_RS00285	COG1328	CTP reductase activity
R2866_RS00290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
R2866_RS00295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
R2866_RS00315	COG0085	RNA polymerase activity
R2866_RS00325	COG1275	C4-dicarboxylate transporter malic acid transport protein
R2866_RS00330	COG1720	tRNA m6t6A37 methyltransferase activity
R2866_RS00335	COG1575	Belongs to the MenA family. Type 1 subfamily
R2866_RS00350	COG1609	Transcriptional regulator
R2866_RS00355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
R2866_RS00360	COG1879	ABC-type sugar transport system periplasmic component
R2866_RS00365	COG1172	Belongs to the binding-protein-dependent transport system permease family
R2866_RS00380	COG1322	Protein conserved in bacteria
R2866_RS00385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
R2866_RS00390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
R2866_RS00400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
R2866_RS00405	COG3700	Belongs to the class B bacterial acid phosphatase family
R2866_RS00410	COG2801	Transposase and inactivated derivatives
R2866_RS00415	COG2963	transposase activity
R2866_RS00425	COG1238	metal cluster binding
R2866_RS00430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
R2866_RS00445	COG3312	ion transport
R2866_RS00470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
R2866_RS00480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
R2866_RS00490	COG0814	amino acid
R2866_RS00495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
R2866_RS00495	COG0140	phosphoribosyl-ATP diphosphatase activity
R2866_RS00500	COG0107	imidazoleglycerol-phosphate synthase activity
R2866_RS00525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
R2866_RS00530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
R2866_RS00535	COG1561	YicC-like family, N-terminal region
R2866_RS00540	COG0354	folic acid binding
R2866_RS00545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
R2866_RS00550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
R2866_RS00555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
R2866_RS00560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
R2866_RS00565	COG2990	Protein conserved in bacteria
R2866_RS00570	COG3956	TIGRFAM MazG family protein
R2866_RS00580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
R2866_RS00585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
R2866_RS00590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
R2866_RS00600	COG0470	DNA polymerase III
R2866_RS00605	COG0084	hydrolase, TatD family'
R2866_RS00615	COG1253	flavin adenine dinucleotide binding
R2866_RS00625	COG3309	Virulence-associated protein D
R2866_RS00635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
R2866_RS00635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
R2866_RS00640	COG1105	Belongs to the carbohydrate kinase PfkB family
R2866_RS00645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
R2866_RS00645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
R2866_RS00645	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
R2866_RS00655	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
R2866_RS00660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
R2866_RS00670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
R2866_RS00675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
R2866_RS00680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
R2866_RS00685	COG4972	Pilus assembly protein
R2866_RS00690	COG3166	PFAM Fimbrial assembly family protein
R2866_RS00705	COG4796	Type ii and iii secretion system protein
R2866_RS00710	COG1040	competence protein
R2866_RS00725	COG3068	Protein conserved in bacteria
R2866_RS00730	COG0776	regulation of translation
R2866_RS00735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
R2866_RS00755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
R2866_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
R2866_RS00770	COG0513	Belongs to the DEAD box helicase family
R2866_RS00775	COG0826	peptidase U32
R2866_RS00780	COG0477	Major facilitator Superfamily
R2866_RS00785	COG0352	thiamine-phosphate diphosphorylase activity
R2866_RS00790	COG0351	phosphomethylpyrimidine kinase
R2866_RS00795	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
R2866_RS00805	COG1530	ribonuclease E activity
R2866_RS00810	COG0564	pseudouridine synthase activity
R2866_RS00815	COG1923	regulation of RNA biosynthetic process
R2866_RS00820	COG3283	Transcriptional regulator of aromatic amino acids metabolism
R2866_RS00825	COG0739	heme binding
R2866_RS00830	COG1121	(ABC) transporter
R2866_RS00835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
R2866_RS00860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
R2866_RS00870	COG3691	Protein conserved in bacteria
R2866_RS00875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
R2866_RS00880	COG0494	nUDIX hydrolase
R2866_RS00890	COG2850	peptidyl-arginine hydroxylation
R2866_RS00905	COG0012	GTP binding
R2866_RS00915	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
R2866_RS00920	COG0318	PFAM AMP-dependent synthetase and ligase
R2866_RS00925	COG3065	identical protein binding
R2866_RS00930	COG1214	PFAM Peptidase M22, glycoprotease
R2866_RS00935	COG1199	ATP-dependent helicase activity
R2866_RS00940	COG0824	Thioesterase
R2866_RS00945	COG0811	peptide transport
R2866_RS00950	COG0848	biopolymer transport protein
R2866_RS00955	COG3064	Membrane
R2866_RS00965	COG2885	chlorophyll binding
R2866_RS00980	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
R2866_RS00985	COG1959	2 iron, 2 sulfur cluster binding
R2866_RS00995	COG0822	iron-sulfur transferase activity
R2866_RS01000	COG0316	Belongs to the HesB IscA family
R2866_RS01005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
R2866_RS01015	COG0443	Heat shock 70 kDa protein
R2866_RS01020	COG0633	Ferredoxin
R2866_RS01025	COG2975	iron-sulfur cluster assembly
R2866_RS01030	COG2976	Protein conserved in bacteria
R2866_RS01045	COG1426	Protein conserved in bacteria
R2866_RS01050	COG3063	Type IV pilus biogenesis stability protein PilW
R2866_RS01060	COG1686	Belongs to the peptidase S11 family
R2866_RS01065	COG0675	Transposase, IS605 OrfB family
R2866_RS01075	COG1121	(ABC) transporter
R2866_RS01080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
R2866_RS01085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
R2866_RS01090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
R2866_RS01095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
R2866_RS01100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
R2866_RS01105	COG1116	anion transmembrane transporter activity
R2866_RS01115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
R2866_RS01120	COG2814	Major facilitator Superfamily
R2866_RS01130	COG3005	denitrification pathway
R2866_RS01135	COG3043	anaerobic respiration
R2866_RS01140	COG0348	domain, Protein
R2866_RS01145	COG0437	4 iron, 4 sulfur cluster binding
R2866_RS01155	COG3062	negative regulation of establishment of protein localization
R2866_RS01160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
R2866_RS01165	COG3171	Protein conserved in bacteria
R2866_RS01175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
R2866_RS01180	COG0628	permease
R2866_RS01185	COG0347	Belongs to the P(II) protein family
R2866_RS01190	COG0521	Mo-molybdopterin cofactor biosynthetic process
R2866_RS01195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
R2866_RS01200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
R2866_RS01210	COG1381	Involved in DNA repair and RecF pathway recombination
R2866_RS01220	COG3061	Opacity-associated protein A
R2866_RS01220	COG3266	domain, Protein
R2866_RS01225	COG1509	lysine 2,3-aminomutase activity
R2866_RS01245	COG2056	Na+-H+ antiporter family
R2866_RS01250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
R2866_RS01255	COG0346	lactoylglutathione lyase activity
R2866_RS01275	COG1755	Isoprenylcysteine carboxyl methyltransferase
R2866_RS01285	COG0494	nUDIX hydrolase
R2866_RS01315	COG4974	Belongs to the 'phage' integrase family
R2866_RS01320	COG2814	Major facilitator Superfamily
R2866_RS01325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
R2866_RS01355	COG1476	TRANSCRIPTIONal
R2866_RS01360	COG0582	viral genome integration into host DNA
R2866_RS01380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
R2866_RS01385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
R2866_RS01390	COG4535	Mg2 and Co2 transporter CorC
R2866_RS01395	COG3023	N-Acetylmuramoyl-L-alanine amidase
R2866_RS01400	COG4969	Belongs to the N-Me-Phe pilin family
R2866_RS01405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
R2866_RS01410	COG1459	type II secretion system
R2866_RS01415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
R2866_RS01420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
R2866_RS01430	COG0789	Transcriptional regulator
R2866_RS01435	COG2608	mercury ion transmembrane transporter activity
R2866_RS01440	COG2608	mercury ion transmembrane transporter activity
R2866_RS01445	COG2608	mercury ion transmembrane transporter activity
R2866_RS01450	COG2217	Heavy metal translocating P-type atpase
R2866_RS01455	COG0814	amino acid
R2866_RS01460	COG1760	l-serine dehydratase
R2866_RS01465	COG0814	amino acid
R2866_RS01470	COG0436	Aminotransferase
R2866_RS01475	COG1169	isochorismate synthase
R2866_RS01485	COG2267	carboxylic ester hydrolase activity
R2866_RS01490	COG0477	Major facilitator Superfamily
R2866_RS01495	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
R2866_RS01500	COG2258	MOSC domain
R2866_RS01505	COG3012	SEC-C Motif Domain Protein
R2866_RS01515	COG1368	sulfuric ester hydrolase activity
R2866_RS01540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
R2866_RS01550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
R2866_RS01560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
R2866_RS01565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
R2866_RS01570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
R2866_RS01580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
R2866_RS01585	COG3850	Histidine kinase
R2866_RS01595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
R2866_RS01600	COG3210	domain, Protein
R2866_RS01610	COG4771	TonB-dependent receptor
R2866_RS01615	COG0859	PFAM glycosyl transferase family 9
R2866_RS01625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
R2866_RS01630	COG1442	glycosyl transferase family 8
R2866_RS01640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
R2866_RS01645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
R2866_RS01655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
R2866_RS01660	COG0811	peptide transport
R2866_RS01665	COG0848	biopolymer transport protein
R2866_RS01670	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
R2866_RS01675	COG0629	single-stranded DNA binding
R2866_RS01680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
R2866_RS01690	COG0641	radical SAM
R2866_RS01705	COG3945	hemerythrin HHE cation binding domain
R2866_RS01710	COG0425	Belongs to the sulfur carrier protein TusA family
R2866_RS01715	COG1862	Preprotein translocase
R2866_RS01720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
R2866_RS01725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
R2866_RS01735	COG1393	Belongs to the ArsC family
R2866_RS01755	COG0513	Belongs to the DEAD box helicase family
R2866_RS01760	COG4785	May be involved in cell division
R2866_RS01775	COG2731	YhcH YjgK YiaL family protein
R2866_RS01780	COG1114	Component of the transport system for branched-chain amino acids
R2866_RS01790	COG1522	sequence-specific DNA binding
R2866_RS01795	COG2962	Rard protein
R2866_RS01805	COG0517	IMP dehydrogenase activity
R2866_RS01805	COG0516	GMP reductase activity
R2866_RS01810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
R2866_RS01810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
R2866_RS01835	COG1573	uracil-dna glycosylase
R2866_RS01845	COG3059	membrane
R2866_RS01860	COG0732	type I restriction modification DNA specificity domain
R2866_RS01870	COG0339	signal peptide processing
R2866_RS01875	COG2832	Protein of unknown function (DUF454)
R2866_RS01880	COG4166	transmembrane transport
R2866_RS01890	COG0671	phosphoesterase, PA-phosphatase related
R2866_RS01895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
R2866_RS01900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
R2866_RS01910	COG0737	Belongs to the 5'-nucleotidase family
R2866_RS01945	COG1560	Kdo2-lipid A biosynthetic process
R2866_RS01950	COG0730	response to heat
R2866_RS01955	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
R2866_RS01965	COG3264	Mechanosensitive ion channel
R2866_RS01965	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
R2866_RS01970	COG0318	PFAM AMP-dependent synthetase and ligase
R2866_RS01975	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
R2866_RS01980	COG0596	Alpha beta hydrolase
R2866_RS01985	COG0716	FMN binding
R2866_RS01990	COG0735	belongs to the Fur family
R2866_RS01995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
R2866_RS02000	COG0805	protein transport
R2866_RS02015	COG0789	Transcriptional regulator
R2866_RS02020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
R2866_RS02025	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
R2866_RS02030	COG1115	amino acid carrier protein
R2866_RS02035	COG1940	carbohydrate kinase activity
R2866_RS02040	COG2116	formate transmembrane transporter activity
R2866_RS02045	COG1882	Formate acetyltransferase
R2866_RS02050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
R2866_RS02060	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
R2866_RS02065	COG0564	pseudouridine synthase activity
R2866_RS02070	COG1496	oxidoreductase activity
R2866_RS02075	COG0482	sulfurtransferase activity
R2866_RS02080	COG2991	Protein conserved in bacteria
R2866_RS02085	COG1477	protein flavinylation
R2866_RS02090	COG2871	sodium ion transport
R2866_RS02105	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
R2866_RS02120	COG0271	Belongs to the BolA IbaG family
R2866_RS02125	COG3056	Lipoprotein
R2866_RS02130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
R2866_RS02135	COG0688	phosphatidylethanolamine metabolic process
R2866_RS02140	COG1399	metal-binding, possibly nucleic acid-binding protein
R2866_RS02160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
R2866_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
R2866_RS02175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
R2866_RS02180	COG2091	lysine biosynthetic process via aminoadipic acid
R2866_RS02185	COG0330	HflC and HflK could
R2866_RS02190	COG0330	HflC and HflK could
R2866_RS02195	COG2020	methyltransferase activity
R2866_RS02205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
R2866_RS02205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
R2866_RS02215	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
R2866_RS02225	COG1737	Transcriptional regulator
R2866_RS02230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
R2866_RS02235	COG0363	glucosamine-6-phosphate deaminase activity
R2866_RS02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
R2866_RS02260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
R2866_RS02275	COG1160	GTP binding
R2866_RS02280	COG2814	Major facilitator Superfamily
R2866_RS02300	COG1840	ABC-type Fe3 transport system, periplasmic component
R2866_RS02310	COG3842	ATPase activity
R2866_RS02315	COG2252	PERMEase
R2866_RS02320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
R2866_RS02340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
R2866_RS02345	COG0450	alkyl hydroperoxide reductase
R2866_RS02350	COG0626	cystathionine gamma-synthase activity
R2866_RS02355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
R2866_RS02360	COG5413	integral membrane protein
R2866_RS02365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
R2866_RS02370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
R2866_RS02375	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
R2866_RS02435	COG2963	transposase activity
R2866_RS02440	COG0625	glutathione transferase activity
R2866_RS02450	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
R2866_RS02455	COG3610	response to peptide
R2866_RS02460	COG3610	response to peptide
R2866_RS02465	COG4536	flavin adenine dinucleotide binding
R2866_RS02470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
R2866_RS02495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
R2866_RS02500	COG0326	Molecular chaperone. Has ATPase activity
R2866_RS02505	COG1393	Belongs to the ArsC family
R2866_RS02515	COG1876	peptidase activity
R2866_RS02520	COG3842	ATPase activity
R2866_RS02525	COG1178	ABC-type Fe3 transport system permease component
R2866_RS02530	COG1840	ABC-type Fe3 transport system, periplasmic component
R2866_RS02535	COG4797	methyltransferase
R2866_RS02540	COG2226	methyltransferase
R2866_RS02545	COG2610	gluconate transmembrane transporter activity
R2866_RS02545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
R2866_RS02550	COG3835	regulator
R2866_RS02555	COG2610	gluconate transmembrane transporter activity
R2866_RS02560	COG1929	Belongs to the glycerate kinase type-1 family
R2866_RS02565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
R2866_RS02570	COG0527	aspartate kinase activity
R2866_RS02570	COG0460	homoserine dehydrogenase
R2866_RS02580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
R2866_RS02590	COG4974	Belongs to the 'phage' integrase family
R2866_RS02660	COG4695	Portal protein
R2866_RS02755	COG5301	cellulose 1,4-beta-cellobiosidase activity
R2866_RS02790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
R2866_RS03005	COG2003	Belongs to the UPF0758 family
R2866_RS03040	COG0629	single-stranded DNA binding
R2866_RS03100	COG0626	cystathionine gamma-synthase activity
R2866_RS03105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
R2866_RS03110	COG3118	belongs to the thioredoxin family
R2866_RS03125	COG0084	hydrolase, TatD family'
R2866_RS03130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
R2866_RS03140	COG1946	Acyl-CoA thioesterase
R2866_RS03150	COG0700	Nucleoside recognition
R2866_RS03155	COG3366	ferrous iron transmembrane transporter activity
R2866_RS03160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
R2866_RS03160	COG1328	CTP reductase activity
R2866_RS03165	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
R2866_RS03170	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
R2866_RS03175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
R2866_RS03185	COG0497	DNA recombination
R2866_RS03190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
R2866_RS03195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
R2866_RS03205	COG0860	N-Acetylmuramoyl-L-alanine amidase
R2866_RS03205	COG1388	LysM domain
R2866_RS03210	COG0802	atpase or kinase
R2866_RS03215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
R2866_RS03220	COG0617	tRNA 3'-terminal CCA addition
R2866_RS03225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
R2866_RS03230	COG2333	competence protein COMEC
R2866_RS03230	COG0658	competence protein
R2866_RS03235	COG1132	(ABC) transporter
R2866_RS03240	COG1663	tetraacyldisaccharide 4'-kinase activity
R2866_RS03255	COG0861	Integral membrane protein TerC family
R2866_RS03260	COG1312	Catalyzes the dehydration of D-mannonate
R2866_RS03265	COG2186	Transcriptional regulator
R2866_RS03270	COG1063	alcohol dehydrogenase
R2866_RS03275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
R2866_RS03280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
R2866_RS03285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
R2866_RS03290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
R2866_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
R2866_RS03300	COG0800	Aldolase
R2866_RS03305	COG2824	Alkylphosphonate utilization operon protein PhnA
R2866_RS03310	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
R2866_RS03320	COG0670	Belongs to the BI1 family
R2866_RS03330	COG0564	pseudouridine synthase activity
R2866_RS03335	COG0708	Exodeoxyribonuclease III
R2866_RS03340	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
R2866_RS03345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
R2866_RS03350	COG1792	Involved in formation and maintenance of cell shape
R2866_RS03355	COG1077	Cell shape determining protein MreB Mrl
R2866_RS03360	COG4178	(ABC) transporter
R2866_RS03370	COG0799	negative regulation of ribosome biogenesis
R2866_RS03380	COG0768	penicillin binding
R2866_RS03385	COG0772	Belongs to the SEDS family
R2866_RS03390	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
R2866_RS03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
R2866_RS03395	COG1686	Belongs to the peptidase S11 family
R2866_RS03410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
R2866_RS03415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
R2866_RS03420	COG3052	prosthetic group binding
R2866_RS03425	COG2301	Belongs to the HpcH HpaI aldolase family
R2866_RS03430	COG3051	citrate lyase alpha subunit
R2866_RS03435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
R2866_RS03435	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
R2866_RS03440	COG0471	metal ion transport
R2866_RS03460	COG0481	GTPase activity
R2866_RS03465	COG0681	Belongs to the peptidase S26 family
R2866_RS03485	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
R2866_RS03490	COG0456	acetyltransferase
R2866_RS03500	COG2864	formate dehydrogenase
R2866_RS03505	COG0437	4 iron, 4 sulfur cluster binding
R2866_RS03520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
R2866_RS03530	COG0561	phosphatase activity
R2866_RS03535	COG1022	Amp-dependent synthetase and ligase
R2866_RS03540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R2866_RS03555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
R2866_RS03560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
R2866_RS03610	COG0583	DNA-binding transcription factor activity
R2866_RS03615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
R2866_RS03620	COG1687	branched-chain amino acid
R2866_RS03635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
R2866_RS03650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
R2866_RS03655	COG1984	allophanate hydrolase subunit 2
R2866_RS03665	COG1914	H( )-stimulated, divalent metal cation uptake system
R2866_RS03675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
R2866_RS03680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
R2866_RS03685	COG3112	Uncharacterised protein family (UPF0231)
R2866_RS03690	COG0316	Belongs to the HesB IscA family
R2866_RS03695	COG0024	Methionine aminopeptidase
R2866_RS03705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
R2866_RS03730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
R2866_RS03735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
R2866_RS03740	COG2190	(PTS) system
R2866_RS03750	COG3111	PFAM Bacterial OB fold (BOF) protein
R2866_RS03755	COG0745	RESPONSE REGULATOR receiver
R2866_RS03760	COG0642	Histidine kinase
R2866_RS03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
R2866_RS03775	COG0795	lipopolysaccharide-transporting ATPase activity
R2866_RS03780	COG0795	lipopolysaccharide-transporting ATPase activity
R2866_RS03785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
R2866_RS03790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
R2866_RS03795	COG2244	polysaccharide biosynthetic process
R2866_RS03805	COG0438	transferase activity, transferring glycosyl groups
R2866_RS03810	COG3306	glycosyltransferase involved in LPS biosynthesis
R2866_RS03815	COG1216	Glycosyl transferase, family 2
R2866_RS03820	COG1216	Glycosyl transferase, family 2
R2866_RS03825	COG2005	Transcriptional regulator
R2866_RS03830	COG0725	ABC transporter, periplasmic molybdate-binding protein
R2866_RS03835	COG4149	molybdate abc transporter
R2866_RS03840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
R2866_RS03845	COG0733	neurotransmitter:sodium symporter activity
R2866_RS03850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
R2866_RS03860	COG4659	FMN binding
R2866_RS03865	COG4658	electron transport chain
R2866_RS03870	COG4656	Part of a membrane complex involved in electron transport
R2866_RS03870	COG4656	Part of a membrane complex involved in electron transport
R2866_RS03880	COG4657	Part of a membrane complex involved in electron transport
R2866_RS03885	COG0616	signal peptide processing
R2866_RS03895	COG1289	transmembrane transporter activity
R2866_RS03900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
R2866_RS03905	COG0517	IMP dehydrogenase activity
R2866_RS03905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
R2866_RS03910	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
R2866_RS03915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
R2866_RS03920	COG0315	cyclic pyranopterin monophosphate synthase activity
R2866_RS03925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
R2866_RS03930	COG0314	molybdopterin synthase activity
R2866_RS03935	COG3008	intermembrane lipid transfer
R2866_RS03940	COG2995	paraquat-inducible protein a
R2866_RS03945	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
R2866_RS03950	COG0793	Belongs to the peptidase S41A family
R2866_RS03955	COG2989	Protein conserved in bacteria
R2866_RS03960	COG3108	Peptidase M15
R2866_RS03965	COG0084	hydrolase, TatD family'
R2866_RS03970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
R2866_RS03975	COG0567	Dehydrogenase, E1 component
R2866_RS03980	COG0508	dehydrogenase complex catalyzes the overall conversion of
R2866_RS03985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
R2866_RS03990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
R2866_RS03995	COG2823	Periplasmic or secreted lipoprotein
R2866_RS04000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
R2866_RS04010	COG3107	peptidoglycan biosynthetic process
R2866_RS04015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
R2866_RS04025	COG0791	NLP P60 protein
R2866_RS04030	COG2198	Histidine kinase
R2866_RS04040	COG0277	FAD linked oxidase domain protein
R2866_RS04055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
R2866_RS04060	COG0539	negative regulation of cytoplasmic translation
R2866_RS04070	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
R2866_RS04075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
R2866_RS04080	COG0284	orotidine-5'-phosphate decarboxylase activity
R2866_RS04085	COG0023	Translation Initiation Factor
R2866_RS04090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
R2866_RS04095	COG2233	PERMEase
R2866_RS04105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
R2866_RS04115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
R2866_RS04120	COG0508	dehydrogenase complex catalyzes the overall conversion of
R2866_RS04125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
R2866_RS04135	COG5339	Protein conserved in bacteria
R2866_RS04140	COG0443	Heat shock 70 kDa protein
R2866_RS04145	COG0484	heat shock protein binding
R2866_RS04155	COG2860	membrane
R2866_RS04165	COG2814	Major facilitator Superfamily
R2866_RS04170	COG1187	pseudouridine synthase activity
R2866_RS04175	COG3955	Domain of unknown function (DUF1919)
R2866_RS04180	COG0280	phosphate acetyltransferase
R2866_RS04180	COG0281	malic enzyme
R2866_RS04185	COG1368	sulfuric ester hydrolase activity
R2866_RS04200	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
R2866_RS04205	COG3683	transport system, periplasmic component
R2866_RS04210	COG3549	Plasmid maintenance system killer
R2866_RS04215	COG3093	addiction module antidote protein HigA
R2866_RS04220	COG0488	(ABC) transporter
R2866_RS04225	COG3094	Invasion gene expression up-regulator, SirB
R2866_RS04230	COG1444	tRNA N-acetyltransferase activity
R2866_RS04235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
R2866_RS04240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
R2866_RS04250	COG0285	dihydrofolate synthase activity
R2866_RS04255	COG2949	membrane
R2866_RS04260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
R2866_RS04265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
R2866_RS04270	COG1944	ATP diphosphatase activity
R2866_RS04280	COG0500	methyltransferase
R2866_RS04285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
R2866_RS04300	COG0489	protein tyrosine kinase activity
R2866_RS04305	COG0778	Nitroreductase
R2866_RS04310	COG1083	cytidylyl-transferase
R2866_RS04330	COG0195	Participates in both transcription termination and antitermination
R2866_RS04335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
R2866_RS04340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
R2866_RS04350	COG0732	type I restriction modification DNA specificity domain
R2866_RS04370	COG1605	Chorismate mutase
R2866_RS04370	COG0287	Prephenate dehydrogenase
R2866_RS04380	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
R2866_RS04385	COG2166	iron-sulfur cluster assembly
R2866_RS04390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
R2866_RS04395	COG1525	nuclease
R2866_RS04405	COG1346	cytolysis
R2866_RS04415	COG0488	(ABC) transporter
R2866_RS04420	COG0288	reversible hydration of carbon dioxide
R2866_RS04440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
R2866_RS04445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
R2866_RS04450	COG1280	lysine exporter protein (LysE YggA)
R2866_RS04460	COG0633	Ferredoxin
R2866_RS04480	COG0776	regulation of translation
R2866_RS04485	COG0791	NLP P60 protein
R2866_RS04495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
R2866_RS04500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
R2866_RS04510	COG1674	ftsk spoiiie
R2866_RS04515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
R2866_RS04535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
R2866_RS04540	COG3119	arylsulfatase activity
R2866_RS04545	COG0676	glucose-6-phosphate 1-epimerase activity
R2866_RS04550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
R2866_RS04555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
R2866_RS04560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
R2866_RS04565	COG1074	ATP-dependent DNA helicase activity
R2866_RS04570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
R2866_RS04580	COG1067	ATP-dependent peptidase activity
R2866_RS04590	COG0515	serine threonine protein kinase
R2866_RS04605	COG3676	manually curated
R2866_RS04615	COG2027	D-alanyl-D-alanine carboxypeptidase
R2866_RS04620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
R2866_RS04625	COG1534	Rna-binding protein
R2866_RS04630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
R2866_RS04635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
R2866_RS04640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
R2866_RS04645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
R2866_RS04650	COG2062	phosphohistidine phosphatase, SixA
R2866_RS04660	COG1538	Outer membrane efflux protein
R2866_RS04670	COG1595	DNA-templated transcription, initiation
R2866_RS04675	COG1476	TRANSCRIPTIONal
R2866_RS04680	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
R2866_RS04690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
R2866_RS04690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
R2866_RS04695	COG0785	Cytochrome C biogenesis protein
R2866_RS04700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R2866_RS04705	COG3099	Belongs to the UPF0263 family
R2866_RS04710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
R2866_RS04715	COG0303	'Molybdopterin
R2866_RS04720	COG0302	gtp cyclohydrolase
R2866_RS04730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
R2866_RS04735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
R2866_RS04750	COG0625	glutathione transferase activity
R2866_RS04755	COG2969	positive regulation of protein catabolic process
R2866_RS04760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
R2866_RS04765	COG0142	geranyltranstransferase activity
R2866_RS04780	COG3098	single-species biofilm formation
R2866_RS04785	COG0564	pseudouridine synthase activity
R2866_RS04795	COG1278	Cold shock
R2866_RS04800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
R2866_RS04805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
R2866_RS04810	COG0159	tryptophan synthase activity
R2866_RS04820	COG4221	oxidoreductase activity
R2866_RS04830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
R2866_RS04835	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
R2866_RS04840	COG0589	response to stress
R2866_RS04845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
R2866_RS04855	COG0582	viral genome integration into host DNA
R2866_RS04955	COG3617	BRO family, N-terminal domain
R2866_RS04965	COG3179	chitinase
R2866_RS04980	COG3728	DNA packaging
R2866_RS04985	COG1783	phage Terminase large subunit
R2866_RS04990	COG3567	Phage-associated protein, HI1409 family
R2866_RS04995	COG2369	cell adhesion
R2866_RS05005	COG3566	protein conserved in bacteria
R2866_RS05015	COG0613	PHP domain protein
R2866_RS05020	COG2268	Band 7 protein
R2866_RS05025	COG0114	fumarate hydratase activity
R2866_RS05030	COG2927	DNA polymerase III (CHI subunit)
R2866_RS05050	COG0298	carbon dioxide binding
R2866_RS05055	COG0134	indole-3-glycerol-phosphate synthase activity
R2866_RS05055	COG0135	phosphoribosylanthranilate isomerase activity
R2866_RS05060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
R2866_RS05065	COG1942	4-Oxalocrotonate Tautomerase
R2866_RS05070	COG0512	Glutamine amidotransferase of anthranilate synthase
R2866_RS05075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
R2866_RS05085	COG1528	Iron-storage protein
R2866_RS05090	COG1528	Iron-storage protein
R2866_RS05095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
R2866_RS05100	COG0573	inorganic phosphate transmembrane transporter activity
R2866_RS05105	COG0581	inorganic phosphate transmembrane transporter activity
R2866_RS05115	COG0745	RESPONSE REGULATOR receiver
R2866_RS05120	COG5002	protein histidine kinase activity
R2866_RS05125	COG2925	Exonuclease
R2866_RS05130	COG0697	spore germination
R2866_RS05135	COG3586	endonuclease activity
R2866_RS05145	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
R2866_RS05150	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
R2866_RS05155	COG0037	tRNA processing
R2866_RS05160	COG2920	part of a sulfur-relay system
R2866_RS05165	COG3585	molybdate ion transport
R2866_RS05170	COG4771	TonB-dependent receptor
R2866_RS05175	COG0612	Peptidase, M16
R2866_RS05180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
R2866_RS05190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
R2866_RS05195	COG0583	DNA-binding transcription factor activity
R2866_RS05200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
R2866_RS05205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
R2866_RS05210	COG0058	SHG alpha-glucan phosphorylase activity
R2866_RS05220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
R2866_RS05225	COG1523	belongs to the glycosyl hydrolase 13 family
R2866_RS05235	COG1640	4-alpha-glucanotransferase
R2866_RS05250	COG1530	ribonuclease E activity
R2866_RS05255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
R2866_RS05270	COG0783	Belongs to the Dps family
R2866_RS05285	COG1176	ABC-type spermidine putrescine transport system, permease component I
R2866_RS05290	COG1177	transmembrane transport
R2866_RS05295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
R2866_RS05300	COG0488	(ABC) transporter
R2866_RS05305	COG0488	(ABC) transporter
R2866_RS05325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
R2866_RS05325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
R2866_RS05330	COG1560	Kdo2-lipid A biosynthetic process
R2866_RS05335	COG0187	DNA topoisomerase II activity
R2866_RS05340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
R2866_RS05345	COG0786	glutamate:sodium symporter activity
R2866_RS05355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
R2866_RS05360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
R2866_RS05375	COG0697	spore germination
R2866_RS05380	COG4750	Nucleotidyl transferase
R2866_RS05385	COG3475	LICD family
R2866_RS05390	COG0616	signal peptide processing
R2866_RS05395	COG0778	Nitroreductase
R2866_RS05400	COG3381	protein complex oligomerization
R2866_RS05405	COG2249	NAD(P)H dehydrogenase (quinone) activity
R2866_RS05415	COG2932	Transcriptional regulator
R2866_RS05420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
R2866_RS05425	COG4591	ABC-type transport system involved in lipoprotein release permease component
R2866_RS05430	COG1136	(ABC) transporter
R2866_RS05435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
R2866_RS05440	COG0500	methyltransferase
R2866_RS05445	COG2830	Protein of unknown function (DUF452)
R2866_RS05455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
R2866_RS05460	COG4591	ABC-type transport system involved in lipoprotein release permease component
R2866_RS05465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
R2866_RS05475	COG2912	Transglutaminase-like superfamily
R2866_RS05480	COG2890	protein-(glutamine-N5) methyltransferase activity
R2866_RS05485	COG1714	RDD family
R2866_RS05510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
R2866_RS05515	COG3101	peptidyl-lysine hydroxylation
R2866_RS05520	COG2369	cell adhesion
R2866_RS05525	COG4383	Mu-like prophage protein gp29
R2866_RS05545	COG0469	pyruvate kinase activity
R2866_RS05550	COG0305	Participates in initiation and elongation during chromosome replication
R2866_RS05555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
R2866_RS05565	COG3676	manually curated
R2866_RS05570	COG1216	Glycosyl transferase, family 2
R2866_RS05575	COG3133	Outer membrane lipoprotein
R2866_RS05585	COG3102	Protein conserved in bacteria
R2866_RS05595	COG0440	acetolactate synthase activity
R2866_RS05600	COG0028	Belongs to the TPP enzyme family
R2866_RS05605	COG1757	Na H antiporter
R2866_RS05610	COG2916	Histone family protein nucleoid-structuring protein H-NS
R2866_RS05615	COG0788	formyltetrahydrofolate deformylase activity
R2866_RS05625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
R2866_RS05630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
R2866_RS05635	COG1674	ftsk spoiiie
R2866_RS05640	COG1522	sequence-specific DNA binding
R2866_RS05645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
R2866_RS05650	COG3025	triphosphatase activity
R2866_RS05655	COG3219	Protein conserved in bacteria
R2866_RS05660	COG3220	belongs to the UPF0276 family
R2866_RS05670	COG2259	Doxx family
R2866_RS05675	COG1392	Phosphate transport regulator
R2866_RS05680	COG0306	phosphate transporter
R2866_RS05685	COG4991	sh3 domain protein
R2866_RS05700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
R2866_RS05705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
R2866_RS05720	COG0534	Mate efflux family protein
R2866_RS05725	COG0307	riboflavin synthase, alpha
R2866_RS05730	COG0308	aminopeptidase N
R2866_RS05770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
R2866_RS05775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
R2866_RS05780	COG1448	Aminotransferase
R2866_RS05785	COG1122	ATPase activity
R2866_RS05790	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
R2866_RS05795	COG0310	cobalt ion transport
R2866_RS05800	COG0310	cobalt ion transport
R2866_RS05805	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
R2866_RS05810	COG0789	Transcriptional regulator
R2866_RS05815	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
R2866_RS05825	COG0251	oxidation-reduction process
R2866_RS05830	COG3105	Protein conserved in bacteria
R2866_RS05835	COG0586	Pfam SNARE associated Golgi protein
R2866_RS05840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
R2866_RS05865	COG0527	aspartate kinase activity
R2866_RS05885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
R2866_RS05890	COG3106	COG3106 Predicted ATPase
R2866_RS05895	COG4166	transmembrane transport
R2866_RS05900	COG4168	peptide transport system, permease
R2866_RS05905	COG4171	peptide transport system, permease
R2866_RS05910	COG4172	Belongs to the ABC transporter superfamily
R2866_RS05915	COG4172	Belongs to the ABC transporter superfamily
R2866_RS05920	COG2855	membrane
R2866_RS05935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
R2866_RS05940	COG1620	l-lactate permease
R2866_RS05945	COG4206	TonB-dependent receptor
R2866_RS05945	COG1629	transport
R2866_RS05950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
R2866_RS05955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
R2866_RS05960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
R2866_RS05965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
R2866_RS05990	COG1090	epimerase
R2866_RS05995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
R2866_RS06000	COG1286	toxin biosynthetic process
R2866_RS06005	COG3092	negative regulation of chromosome organization
R2866_RS06015	COG0280	phosphate acetyltransferase
R2866_RS06015	COG0857	belongs to the CobB CobQ family
R2866_RS06020	COG2840	Smr protein MutS2
R2866_RS06025	COG2890	protein-(glutamine-N5) methyltransferase activity
R2866_RS06030	COG0583	DNA-binding transcription factor activity
R2866_RS06035	COG1187	pseudouridine synthase activity
R2866_RS06040	COG0009	L-threonylcarbamoyladenylate synthase
R2866_RS06045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
R2866_RS06055	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
R2866_RS06060	COG0583	DNA-binding transcription factor activity
R2866_RS06065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
R2866_RS06080	COG0720	synthase
R2866_RS06085	COG0602	queuosine metabolic process
R2866_RS06090	COG0210	DNA helicase
R2866_RS06095	COG0601	transmembrane transport
R2866_RS06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
R2866_RS06105	COG0444	Belongs to the ABC transporter superfamily
R2866_RS06110	COG4608	Belongs to the ABC transporter superfamily
R2866_RS06115	COG1793	dna ligase
R2866_RS06125	COG1126	abc transporter atp-binding protein
R2866_RS06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
R2866_RS06135	COG4215	(ABC) transporter
R2866_RS06140	COG4160	amino acid transport
R2866_RS06150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
R2866_RS06155	COG3091	SprT-like family
R2866_RS06165	COG0512	Glutamine amidotransferase of anthranilate synthase
R2866_RS06170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
R2866_RS06175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
R2866_RS06185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
R2866_RS06205	COG0247	lactate metabolic process
R2866_RS06205	COG0277	FAD linked oxidase domain protein
R2866_RS06210	COG2050	protein possibly involved in aromatic compounds catabolism
R2866_RS06220	COG3118	belongs to the thioredoxin family
R2866_RS06225	COG0492	ferredoxin-NADP+ reductase activity
R2866_RS06230	COG4988	ABC transporter
R2866_RS06235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
R2866_RS06240	COG0602	queuosine metabolic process
R2866_RS06245	COG1823	symporter activity
R2866_RS06250	COG1280	lysine exporter protein (LysE YggA)
R2866_RS06255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
R2866_RS06260	COG0312	modulator of DNA gyrase
R2866_RS06270	COG3117	lipopolysaccharide transmembrane transporter activity
R2866_RS06275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
R2866_RS06280	COG1137	ATPase activity
R2866_RS06285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
R2866_RS06295	COG0077	Prephenate dehydratase
R2866_RS06295	COG1605	Chorismate mutase
R2866_RS06300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
R2866_RS06305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
R2866_RS06310	COG0849	cell division
R2866_RS06315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
R2866_RS06335	COG0772	Belongs to the SEDS family
R2866_RS06340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
R2866_RS06350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
R2866_RS06360	COG0768	penicillin binding
R2866_RS06365	COG3116	cell division
R2866_RS06370	COG0275	rRNA processing
R2866_RS06380	COG1966	Carbon starvation protein
R2866_RS06390	COG4166	transmembrane transport
R2866_RS06395	COG0601	transmembrane transport
R2866_RS06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
R2866_RS06405	COG0444	Belongs to the ABC transporter superfamily
R2866_RS06410	COG4608	Belongs to the ABC transporter superfamily
R2866_RS06415	COG2990	Protein conserved in bacteria
R2866_RS06430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
R2866_RS06435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R2866_RS06440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
R2866_RS06445	COG1070	Carbohydrate kinase
R2866_RS06455	COG4213	ABC transporter substrate-binding protein
R2866_RS06460	COG1129	ABC transporter
R2866_RS06465	COG4214	carbohydrate transport
R2866_RS06470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
R2866_RS06475	COG1757	Na H antiporter
R2866_RS06480	COG1609	Transcriptional regulator
R2866_RS06480	COG2207	Transcriptional regulator
R2866_RS06485	COG0859	PFAM glycosyl transferase family 9
R2866_RS06490	COG2814	Major facilitator Superfamily
R2866_RS06495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
R2866_RS06505	COG3115	cell septum assembly
R2866_RS06510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
R2866_RS06535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R2866_RS06540	COG1138	Cytochrome C-type biogenesis protein
R2866_RS06550	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
R2866_RS06555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
R2866_RS06560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
R2866_RS06565	COG4133	protoheme IX ABC transporter activity
R2866_RS06570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
R2866_RS06575	COG1127	ABC transporter
R2866_RS06580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
R2866_RS06585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
R2866_RS06590	COG2854	intermembrane phospholipid transfer
R2866_RS06595	COG3113	response to antibiotic
R2866_RS06600	COG5007	Belongs to the BolA IbaG family
R2866_RS06610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
R2866_RS06615	COG0765	amino acid transport
R2866_RS06620	COG1126	abc transporter atp-binding protein
R2866_RS06625	COG3201	nicotinamide mononucleotide transporter
R2866_RS06635	COG1271	oxidase subunit
R2866_RS06640	COG1294	oxidase, subunit
R2866_RS06650	COG2363	Small membrane protein
R2866_RS06655	COG1643	Atp-dependent helicase
R2866_RS06680	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
R2866_RS06685	COG0437	4 iron, 4 sulfur cluster binding
R2866_RS06690	COG3301	Polysulphide reductase, NrfD
R2866_RS06700	COG2194	sulfuric ester hydrolase activity
R2866_RS06715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
R2866_RS06725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
R2866_RS06730	COG3421	Type III restriction
R2866_RS06735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
R2866_RS06740	COG1917	Cupin 2, conserved barrel domain protein
R2866_RS06740	COG4977	sequence-specific DNA binding
R2866_RS06745	COG1132	(ABC) transporter
R2866_RS06750	COG2608	mercury ion transmembrane transporter activity
R2866_RS06760	COG1305	Transglutaminase-like
R2866_RS06765	COG0243	molybdopterin cofactor binding
R2866_RS06770	COG0437	4 iron, 4 sulfur cluster binding
R2866_RS06775	COG3302	dmso reductase anchor subunit
R2866_RS06780	COG3381	protein complex oligomerization
R2866_RS06785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
R2866_RS06785	COG2221	Nitrite and sulphite reductase 4Fe-4S
R2866_RS06805	COG1373	ATPase (AAA superfamily
R2866_RS06810	COG0121	glutamine amidotransferase
R2866_RS06815	COG0762	integral membrane protein
R2866_RS06830	COG0560	Phosphoserine phosphatase
R2866_RS06835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
R2866_RS06845	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
R2866_RS06850	COG1178	ABC-type Fe3 transport system permease component
R2866_RS06855	COG4143	(ABC) transporter
R2866_RS06860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
R2866_RS06865	COG2610	gluconate transmembrane transporter activity
R2866_RS06870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
R2866_RS06875	COG3622	Belongs to the hyi family
R2866_RS06880	COG0235	Class ii aldolase
R2866_RS06885	COG3395	kinase activity
R2866_RS06890	COG2084	Dehydrogenase
R2866_RS06895	COG1349	DNA-binding transcription factor activity
R2866_RS06900	COG1555	photosystem II stabilization
R2866_RS06910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
R2866_RS06915	COG2194	sulfuric ester hydrolase activity
R2866_RS06920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
R2866_RS06925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
R2866_RS06940	COG0594	ribonuclease P activity
R2866_RS06950	COG4783	chaperone-mediated protein folding
R2866_RS06960	COG4771	TonB-dependent receptor
R2866_RS06960	COG1629	transport
R2866_RS06965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
R2866_RS06975	COG0592	DNA-directed DNA polymerase activity
R2866_RS06985	COG3468	outer membrane autotransporter barrel domain protein
R2866_RS06985	COG3266	domain, Protein
R2866_RS07010	COG0758	DNA mediated transformation
R2866_RS07040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
R2866_RS07050	COG2184	nucleotidyltransferase activity
R2866_RS07055	COG0697	spore germination
R2866_RS07060	COG4145	pantothenate transmembrane transporter activity
R2866_RS07065	COG3924	membrane
R2866_RS07070	COG0439	Biotin carboxylase
R2866_RS07075	COG0511	ligase activity, forming carbon-carbon bonds
R2866_RS07085	COG1441	menaquinone biosynthetic process
R2866_RS07090	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
R2866_RS07110	COG0728	peptidoglycan biosynthetic process
R2866_RS07115	COG0196	riboflavin kinase activity
R2866_RS07125	COG0537	adenosine 5'-monophosphoramidase activity
R2866_RS07130	COG5633	Lipoprotein
R2866_RS07135	COG1472	Belongs to the glycosyl hydrolase 3 family
R2866_RS07140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
R2866_RS07145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
R2866_RS07165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
R2866_RS07170	COG2003	Belongs to the UPF0758 family
R2866_RS07185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
R2866_RS07195	COG1487	ribonuclease activity
R2866_RS07200	COG0076	glutamate decarboxylase activity
R2866_RS07210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
R2866_RS07215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
R2866_RS07215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
R2866_RS07220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
R2866_RS07225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
R2866_RS07240	COG4795	General secretion pathway protein
R2866_RS07245	COG2165	general secretion pathway protein
R2866_RS07250	COG0483	inositol monophosphate 1-phosphatase activity
R2866_RS07255	COG1138	Cytochrome C-type biogenesis protein
R2866_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R2866_RS07265	COG3088	subunit of a heme lyase
R2866_RS07265	COG4235	cytochrome complex assembly
R2866_RS07270	COG2081	HI0933 family
R2866_RS07280	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
R2866_RS07290	COG0754	glutathionylspermidine amidase activity
R2866_RS07295	COG0753	catalase activity
R2866_RS07305	COG4545	Glutaredoxin-related protein
R2866_RS07310	COG2852	Protein conserved in bacteria
R2866_RS07315	COG0751	glycine-tRNA ligase activity
R2866_RS07325	COG1466	dna polymerase III delta subunit
R2866_RS07330	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
R2866_RS07340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
R2866_RS07345	COG0575	Belongs to the CDS family
R2866_RS07350	COG0750	zinc metalloprotease
R2866_RS07360	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
R2866_RS07380	COG2226	methyltransferase
R2866_RS07385	COG0475	glutathione-regulated potassium exporter activity
R2866_RS07385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
R2866_RS07390	COG0494	nUDIX hydrolase
R2866_RS07405	COG4701	Protein of unknown function (DUF721)
R2866_RS07410	COG0590	tRNA wobble adenosine to inosine editing
R2866_RS07425	COG0730	response to heat
R2866_RS07440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
R2866_RS07445	COG1566	PFAM secretion protein HlyD family protein
R2866_RS07450	COG2814	Major facilitator Superfamily
R2866_RS07455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
R2866_RS07460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
R2866_RS07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R2866_RS07470	COG1309	transcriptional regulator
R2866_RS07485	COG0237	dephospho-CoA kinase activity
R2866_RS07495	COG0151	Belongs to the GarS family
R2866_RS07500	COG0138	bifunctional purine biosynthesis protein purh
R2866_RS07505	COG2259	Doxx family
R2866_RS07515	COG0745	RESPONSE REGULATOR receiver
R2866_RS07520	COG1115	amino acid carrier protein
R2866_RS07525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
R2866_RS07530	COG0142	geranyltranstransferase activity
R2866_RS07545	COG0697	spore germination
R2866_RS07565	COG3307	-O-antigen
R2866_RS07570	COG1088	dTDP-glucose 4,6-dehydratase activity
R2866_RS07575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
R2866_RS07595	COG1216	Glycosyl transferase, family 2
R2866_RS07600	COG0463	Glycosyl transferase, family 2
R2866_RS07610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
R2866_RS07615	COG0174	glutamine synthetase
R2866_RS07620	COG1217	gtp-binding protein TYPA
R2866_RS07630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
R2866_RS07635	COG3306	glycosyltransferase involved in LPS biosynthesis
R2866_RS07660	COG1120	ATPase activity
R2866_RS07680	COG0557	exoribonuclease II activity
R2866_RS07685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
R2866_RS07690	COG0542	response to heat
R2866_RS07695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
R2866_RS07705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
R2866_RS07705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
R2866_RS07715	COG0748	coenzyme F420 binding
R2866_RS07720	COG0747	negative chemotaxis
R2866_RS07725	COG2814	Major facilitator Superfamily
R2866_RS07730	COG1763	Mo-molybdopterin cofactor biosynthetic process
R2866_RS07740	COG3086	response to oxidative stress
R2866_RS07750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
R2866_RS07755	COG3085	chromosome segregation
R2866_RS07760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
R2866_RS07765	COG3084	Protein conserved in bacteria
R2866_RS07770	COG0746	molybdenum cofactor guanylyltransferase activity
R2866_RS07775	COG0402	S-adenosylhomocysteine deaminase activity
R2866_RS07780	COG3083	sulfuric ester hydrolase activity
R2866_RS07795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
R2866_RS07800	COG0745	RESPONSE REGULATOR receiver
R2866_RS07810	COG1053	succinate dehydrogenase
R2866_RS07815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
R2866_RS07820	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
R2866_RS07825	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
R2866_RS07830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
R2866_RS07840	COG0741	lytic transglycosylase activity
R2866_RS07845	COG2350	Protein conserved in bacteria
R2866_RS07850	COG1607	acyl-coa hydrolase
R2866_RS07865	COG4211	Belongs to the binding-protein-dependent transport system permease family
R2866_RS07870	COG1129	ABC transporter
R2866_RS07875	COG1879	ABC-type sugar transport system periplasmic component
R2866_RS07880	COG1609	Transcriptional regulator
R2866_RS07885	COG1085	galactose-1-phosphate uridylyltransferase
R2866_RS07890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
R2866_RS07895	COG2017	converts alpha-aldose to the beta-anomer
R2866_RS07905	COG0006	proline dipeptidase activity
R2866_RS07910	COG0589	response to stress
R2866_RS07925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
R2866_RS07955	COG0730	response to heat
R2866_RS07960	COG0641	radical SAM
R2866_RS07965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
R2866_RS08000	COG0201	protein transport
R2866_RS08085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
R2866_RS08105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
R2866_RS08110	COG0051	transcription antitermination factor activity, RNA binding
R2866_RS08115	COG0583	DNA-binding transcription factor activity
R2866_RS08120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
R2866_RS08125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
R2866_RS08130	COG2031	fatty acid transporter
R2866_RS08135	COG0183	Belongs to the thiolase family
R2866_RS08140	COG2177	Part of the ABC transporter FtsEX involved in
R2866_RS08145	COG2884	Cell division ATP-binding protein ftsE
R2866_RS08150	COG0552	protein localization to endoplasmic reticulum
R2866_RS08155	COG0742	ribosomal rna small subunit methyltransferase
R2866_RS08160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
R2866_RS08165	COG3306	glycosyltransferase involved in LPS biosynthesis
R2866_RS08175	COG3172	ATPase kinase involved in NAD metabolism
R2866_RS08180	COG2129	metallophosphoesterase
R2866_RS08205	COG1194	a g-specific adenine glycosylase
R2866_RS08220	COG4942	peptidase
R2866_RS08225	COG2861	carbohydrate metabolic process
R2866_RS08240	COG0047	phosphoribosylformylglycinamidine synthase activity
R2866_RS08240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
R2866_RS08245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
R2866_RS08250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
R2866_RS08265	COG1252	NADH dehydrogenase
R2866_RS08270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
R2866_RS08275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
R2866_RS08280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
R2866_RS08285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
R2866_RS08290	COG0587	DNA-directed DNA polymerase activity
R2866_RS08295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
R2866_RS08305	COG0028	Belongs to the TPP enzyme family
R2866_RS08310	COG0733	neurotransmitter:sodium symporter activity
R2866_RS08325	COG0204	Acyl-transferase
R2866_RS08345	COG0514	ATP-dependent DNA helicase (RecQ)
R2866_RS08355	COG0019	diaminopimelate decarboxylase activity
R2866_RS08360	COG2197	response regulator
R2866_RS08400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
R2866_RS08415	COG1464	Belongs to the NlpA lipoprotein family
R2866_RS08420	COG1349	DNA-binding transcription factor activity
R2866_RS08425	COG0705	Rhomboid family
R2866_RS08430	COG0564	pseudouridine synthase activity
R2866_RS08440	COG1349	DNA-binding transcription factor activity
R2866_RS08445	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
R2866_RS08460	COG0235	Class ii aldolase
R2866_RS08465	COG0738	Major facilitator superfamily
R2866_RS08485	COG0471	metal ion transport
R2866_RS08490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
R2866_RS08495	COG1045	serine acetyltransferase
R2866_RS08500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
R2866_RS08505	COG3072	Adenylate cyclase
R2866_RS08510	COG2959	enzyme of heme biosynthesis
R2866_RS08515	COG3071	HemY protein
R2866_RS08525	COG4695	Portal protein
R2866_RS08565	COG3772	lysozyme
R2866_RS08630	COG5301	cellulose 1,4-beta-cellobiosidase activity
R2866_RS08680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
R2866_RS08745	COG0582	viral genome integration into host DNA
R2866_RS08790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
R2866_RS08795	COG1739	Uncharacterized protein family UPF0029
R2866_RS08810	COG0251	oxidation-reduction process
R2866_RS08815	COG2853	Lipoprotein
R2866_RS08820	COG0250	Participates in transcription elongation, termination and antitermination
R2866_RS08825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
R2866_RS08830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
R2866_RS08855	COG3276	selenocysteine insertion sequence binding
R2866_RS08870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
R2866_RS08875	COG0814	amino acid
R2866_RS08885	COG1388	LysM domain
R2866_RS08885	COG4942	peptidase
R2866_RS08895	COG1238	metal cluster binding
R2866_RS08905	COG0585	pseudouridine synthase activity
R2866_RS08910	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
R2866_RS08925	COG1047	Peptidyl-prolyl cis-trans
R2866_RS08930	COG0729	surface antigen
R2866_RS08935	COG2911	Protein conserved in bacteria
R2866_RS08940	COG0248	Ppx GppA phosphatase
R2866_RS08945	COG1187	pseudouridine synthase activity
R2866_RS08950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
R2866_RS08955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
R2866_RS08960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
R2866_RS08965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
R2866_RS08970	COG0584	glycerophosphoryl diester phosphodiesterase
R2866_RS08975	COG2271	Major facilitator Superfamily
R2866_RS08980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
R2866_RS08990	COG0247	lactate metabolic process
R2866_RS09005	COG0583	DNA-binding transcription factor activity
R2866_RS09010	COG2962	Rard protein
R2866_RS09025	COG0456	acetyltransferase
R2866_RS09030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
R2866_RS09035	COG2195	Cleaves the N-terminal amino acid of tripeptides
R2866_RS09065	COG0716	FMN binding
R2866_RS09075	COG1494	fructose-1,6-bisphosphatase
R2866_RS09085	COG3550	peptidyl-serine autophosphorylation
R2866_RS09090	COG3550	peptidyl-serine autophosphorylation
R2866_RS09095	COG1132	(ABC) transporter
R2866_RS09100	COG4988	ABC transporter
R2866_RS09110	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
R2866_RS09115	COG3620	sequence-specific DNA binding
R2866_RS09120	COG0488	(ABC) transporter
R2866_RS09125	COG0551	DNA topoisomerase type I activity
R2866_RS09145	COG2818	Glycosylase
R2866_RS09150	COG0463	Glycosyl transferase, family 2
R2866_RS09155	COG1519	Transferase
R2866_RS09165	COG5645	(Lipo)protein
R2866_RS09170	COG0210	DNA helicase
R2866_RS09190	COG2249	NAD(P)H dehydrogenase (quinone) activity
R2866_RS09195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
R2866_RS09200	COG1285	pathogenesis
R2866_RS09205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
R2866_RS09210	COG2267	carboxylic ester hydrolase activity
R2866_RS09215	COG3005	denitrification pathway
R2866_RS09220	COG0243	molybdopterin cofactor binding
R2866_RS09260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
R2866_RS09270	COG0180	Tryptophanyl-tRNA synthetase
R2866_RS09275	COG3691	Protein conserved in bacteria
R2866_RS09280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
R2866_RS09285	COG0038	chloride channel
R2866_RS09320	COG1072	(Pantothenic acid kinase))
R2866_RS09325	COG3026	antisigma factor binding
R2866_RS09330	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
R2866_RS09335	COG1595	DNA-templated transcription, initiation
R2866_RS09340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
R2866_RS09350	COG0569	domain protein
R2866_RS09355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
R2866_RS09355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
R2866_RS09360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
R2866_RS09405	COG3070	regulator of competence-specific genes
R2866_RS09425	COG0561	phosphatase activity
R2866_RS09430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
R2866_RS09435	COG1982	Orn Lys Arg decarboxylase major
R2866_RS09440	COG0531	amino acid
R2866_RS09445	COG3086	response to oxidative stress
R2866_RS09455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
R2866_RS09465	COG3069	C4-dicarboxylate transmembrane transporter activity
R2866_RS09470	COG1473	amidohydrolase
R2866_RS09475	COG0737	Belongs to the 5'-nucleotidase family
R2866_RS09480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
R2866_RS09490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
R2866_RS09500	COG0789	Transcriptional regulator