locus-tag	class	description
HI0001	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HI0002	COG1022	Amp-dependent synthetase and ligase
HI0003	COG0561	phosphatase activity
HI0004	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HI0005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HI0007	COG0437	4 iron, 4 sulfur cluster binding
HI0008	COG2864	formate dehydrogenase
HI0009	COG3058	Necessary for formate dehydrogenase activity
HI0010	COG0456	acetyltransferase
HI0011	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HI0012	COG2813	Specifically methylates the guanine in position
HI0014	COG0571	ribonuclease III activity
HI0015	COG0681	Belongs to the peptidase S26 family
HI0016	COG0481	GTPase activity
HI0018	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HI0020	COG0471	metal ion transport
HI0021	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HI0021	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HI0022	COG3051	citrate lyase alpha subunit
HI0023	COG2301	Belongs to the HpcH HpaI aldolase family
HI0024	COG3052	prosthetic group binding
HI0025	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HI0026	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HI0027	COG0321	lipoyl(octanoyl) transferase activity
HI0029	COG1686	Belongs to the peptidase S11 family
HI0030	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HI0030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HI0031	COG0772	Belongs to the SEDS family
HI0032	COG0768	penicillin binding
HI0034	COG0799	negative regulation of ribosome biogenesis
HI0035	COG2985	domain, Protein
HI0036	COG4178	(ABC) transporter
HI0037	COG1077	Cell shape determining protein MreB Mrl
HI0038	COG1792	Involved in formation and maintenance of cell shape
HI0039	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HI0040	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HI0041	COG0708	Exodeoxyribonuclease III
HI0042	COG0564	pseudouridine synthase activity
HI0043	COG3768	UPF0283 membrane protein
HI0044	COG0670	Belongs to the BI1 family
HI0045	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HI0046	COG2824	Alkylphosphonate utilization operon protein PhnA
HI0047	COG0800	Aldolase
HI0048	COG1028	Short-chain dehydrogenase reductase Sdr
HI0049	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI0050m	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HI0051	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HI0052	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HI0053	COG1063	alcohol dehydrogenase
HI0054	COG2186	Transcriptional regulator
HI0055	COG1312	Catalyzes the dehydration of D-mannonate
HI0056	COG0861	Integral membrane protein TerC family
HI0057	COG0322	excinuclease ABC activity
HI0058	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HI0059	COG1663	tetraacyldisaccharide 4'-kinase activity
HI0060	COG1132	(ABC) transporter
HI0061	COG0658	competence protein
HI0061	COG2333	competence protein COMEC
HI0062	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HI0063	COG0617	tRNA 3'-terminal CCA addition
HI0064	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HI0065	COG0802	atpase or kinase
HI0066	COG0860	N-Acetylmuramoyl-L-alanine amidase
HI0066	COG1388	LysM domain
HI0067	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HI0068	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HI0069	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HI0070	COG0497	DNA recombination
HI0071	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HI0072	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HI0073	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HI0074	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HI0075	COG1328	CTP reductase activity
HI0075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HI0076	COG1946	Acyl-CoA thioesterase
HI0077	COG2833	Protein of unknown function (DUF455)
HI0078	COG0215	cysteine-tRNA ligase activity
HI0079	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HI0080	COG3692	DNA binding
HI0081	COG0084	hydrolase, TatD family'
HI0082	COG1960	acyl-CoA dehydrogenase activity
HI0084	COG3118	belongs to the thioredoxin family
HI0085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HI0086	COG0626	cystathionine gamma-synthase activity
HI0087	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HI0089	COG0460	homoserine dehydrogenase
HI0089	COG0527	aspartate kinase activity
HI0090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HI0091	COG1929	Belongs to the glycerate kinase type-1 family
HI0092	COG2610	gluconate transmembrane transporter activity
HI0093	COG3835	regulator
HI0094	COG2610	gluconate transmembrane transporter activity
HI0094	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI0095	COG2226	methyltransferase
HI0096	COG4797	methyltransferase
HI0098	COG1178	ABC-type Fe3 transport system permease component
HI0099	COG3842	ATPase activity
HI0102	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI0103	COG1393	Belongs to the ArsC family
HI0104	COG0326	Molecular chaperone. Has ATPase activity
HI0105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HI0106	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HI0107	COG4536	flavin adenine dinucleotide binding
HI0108	COG3610	response to peptide
HI0109	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HI0110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HI0111	COG0625	glutathione transferase activity
HI0112	COG2963	transposase activity
HI0113	COG1629	transport
HI0117	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HI0118	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HI0119	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HI0120	COG5413	integral membrane protein
HI0121	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HI0122	COG0626	cystathionine gamma-synthase activity
HI0123	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI0124	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HI0125	COG2252	PERMEase
HI0126	COG3842	ATPase activity
HI0129	COG1178	ABC-type Fe3 transport system permease component
HI0131	COG1840	ABC-type Fe3 transport system, periplasmic component
HI0133	COG0717	Belongs to the dCTP deaminase family
HI0135	COG2814	Major facilitator Superfamily
HI0136	COG1160	GTP binding
HI0137	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI0138	COG0328	RNA-DNA hybrid ribonuclease activity
HI0139	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HI0140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HI0141	COG0363	glucosamine-6-phosphate deaminase activity
HI0142	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HI0143	COG1737	Transcriptional regulator
HI0144	COG1940	carbohydrate kinase activity
HI0145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HI0146	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HI0147	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HI0147	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HI0148	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HI0150	COG0330	HflC and HflK could
HI0151	COG0330	HflC and HflK could
HI0152	COG2091	lysine biosynthetic process via aminoadipic acid
HI0155	COG1028	Short-chain dehydrogenase reductase Sdr
HI0156	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI0159	COG1399	metal-binding, possibly nucleic acid-binding protein
HI0160	COG0688	phosphatidylethanolamine metabolic process
HI0161	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI0162	COG3056	Lipoprotein
HI0163	COG0271	Belongs to the BolA IbaG family
HI0164	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HI0167	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HI0170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HI0171	COG2871	sodium ion transport
HI0172	COG1477	protein flavinylation
HI0173	COG2991	Protein conserved in bacteria
HI0174	COG0482	sulfurtransferase activity
HI0175	COG1496	oxidoreductase activity
HI0176	COG0564	pseudouridine synthase activity
HI0177	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HI0179	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI0180	COG1882	Formate acetyltransferase
HI0181	COG2116	formate transmembrane transporter activity
HI0182	COG1940	carbohydrate kinase activity
HI0183	COG1115	amino acid carrier protein
HI0184	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HI0185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HI0186	COG0789	Transcriptional regulator
HI0188	COG0805	protein transport
HI0189	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HI0190	COG0735	belongs to the Fur family
HI0191	COG0716	FMN binding
HI0192	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HI0193	COG0596	Alpha beta hydrolase
HI0194	COG0318	PFAM AMP-dependent synthetase and ligase
HI0195.1	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HI0195.1	COG3264	Mechanosensitive ion channel
HI0196	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HI0197	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HI0198	COG0730	response to heat
HI0199	COG1560	Kdo2-lipid A biosynthetic process
HI0206	COG0737	Belongs to the 5'-nucleotidase family
HI0208	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HI0209	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HI0211	COG0671	phosphoesterase, PA-phosphatase related
HI0213	COG4166	transmembrane transport
HI0214	COG0339	signal peptide processing
HI0216	COG0732	type I restriction modification DNA specificity domain
HI0217	COG1943	Transposase
HI0219	COG3059	membrane
HI0219a	COG2198	Histidine kinase
HI0219a	COG5002	protein histidine kinase activity
HI0219a	COG0784	Response regulator, receiver
HI0220.1	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HI0220.1	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HI0220.2	COG1573	uracil-dna glycosylase
HI0221	COG0516	GMP reductase activity
HI0221	COG0517	IMP dehydrogenase activity
HI0221.1	COG0516	GMP reductase activity
HI0222	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HI0222	COG0519	Catalyzes the synthesis of GMP from XMP
HI0223	COG2962	Rard protein
HI0224	COG1522	sequence-specific DNA binding
HI0225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HI0226	COG1114	Component of the transport system for branched-chain amino acids
HI0227	COG2731	YhcH YjgK YiaL family protein
HI0229	COG1185	polyribonucleotide nucleotidyltransferase activity
HI0230	COG4785	May be involved in cell division
HI0231	COG0513	Belongs to the DEAD box helicase family
HI0232	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HI0235	COG3036	rescue of stalled ribosome
HI0236	COG1393	Belongs to the ArsC family
HI0239	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HI0240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HI0241	COG1862	Preprotein translocase
HI0242	COG0425	Belongs to the sulfur carrier protein TusA family
HI0243	COG3945	hemerythrin HHE cation binding domain
HI0244	COG0343	queuine tRNA-ribosyltransferase activity
HI0245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HI0246	COG0641	radical SAM
HI0249	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HI0250	COG0629	single-stranded DNA binding
HI0251	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HI0252	COG0848	biopolymer transport protein
HI0253	COG0811	peptide transport
HI0254	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HI0255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HI0256	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HI0257	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HI0258	COG1442	glycosyl transferase family 8
HI0260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HI0260.1	COG3642	lipopolysaccharide core region biosynthetic process
HI0261	COG0859	PFAM glycosyl transferase family 9
HI0262	COG4771	TonB-dependent receptor
HI0263	COG2831	hemolysin activation secretion protein
HI0264	COG3210	domain, Protein
HI0265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HI0267	COG3850	Histidine kinase
HI0268	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HI0269	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HI0270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI0271	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HI0273	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HI0274	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HI0275	COG1368	sulfuric ester hydrolase activity
HI0277	COG3012	SEC-C Motif Domain Protein
HI0280	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HI0281	COG0477	Major facilitator Superfamily
HI0282	COG2267	carboxylic ester hydrolase activity
HI0283	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HI0285	COG1169	isochorismate synthase
HI0286	COG0436	Aminotransferase
HI0287	COG0814	amino acid
HI0288	COG1760	l-serine dehydratase
HI0289	COG0814	amino acid
HI0290	COG2217	Heavy metal translocating P-type atpase
HI0291	COG2608	mercury ion transmembrane transporter activity
HI0292	COG2608	mercury ion transmembrane transporter activity
HI0293	COG0789	Transcriptional regulator
HI0295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HI0296	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HI0297	COG1459	type II secretion system
HI0298	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HI0299	COG4969	Belongs to the N-Me-Phe pilin family
HI0300	COG3023	N-Acetylmuramoyl-L-alanine amidase
HI0301	COG4535	Mg2 and Co2 transporter CorC
HI0302	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HI0303	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HI0304	COG1678	Uncharacterized ACR, COG1678
HI0307	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HI0308	COG2814	Major facilitator Superfamily
HI0309	COG4974	Belongs to the 'phage' integrase family
HI0312	COG2255	four-way junction helicase activity
HI0313	COG0632	four-way junction helicase activity
HI0314	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HI0316	COG0494	nUDIX hydrolase
HI0317	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HI0318	COG1755	Isoprenylcysteine carboxyl methyltransferase
HI0319	COG4106	trans-aconitate 2-methyltransferase activity
HI0322	COG1487	ribonuclease activity
HI0323	COG0346	lactoylglutathione lyase activity
HI0324	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI0325	COG2056	Na+-H+ antiporter family
HI0329	COG1509	lysine 2,3-aminomutase activity
HI0330	COG3061	Opacity-associated protein A
HI0330	COG3266	domain, Protein
HI0332	COG1381	Involved in DNA repair and RecF pathway recombination
HI0333	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI0334	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HI0335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HI0336	COG0521	Mo-molybdopterin cofactor biosynthetic process
HI0337	COG0347	Belongs to the P(II) protein family
HI0338	COG0628	permease
HI0339	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HI0340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HI0341	COG3171	Protein conserved in bacteria
HI0343	COG3062	negative regulation of establishment of protein localization
HI0345	COG0437	4 iron, 4 sulfur cluster binding
HI0346	COG0348	domain, Protein
HI0347	COG3043	anaerobic respiration
HI0348	COG3005	denitrification pathway
HI0350	COG2814	Major facilitator Superfamily
HI0351	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HI0354	COG1116	anion transmembrane transporter activity
HI0355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HI0357	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HI0358	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HI0359	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI0360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI0361	COG1121	(ABC) transporter
HI0364	COG1686	Belongs to the peptidase S11 family
HI0365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HI0366	COG3063	Type IV pilus biogenesis stability protein PilW
HI0367	COG1426	Protein conserved in bacteria
HI0368	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HI0369	COG0124	histidyl-tRNA synthetase
HI0370	COG2976	Protein conserved in bacteria
HI0371	COG2975	iron-sulfur cluster assembly
HI0372	COG0633	Ferredoxin
HI0373	COG0443	Heat shock 70 kDa protein
HI0375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HI0376	COG0316	Belongs to the HesB IscA family
HI0377	COG0822	iron-sulfur transferase activity
HI0379	COG1959	2 iron, 2 sulfur cluster binding
HI0380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HI0381	COG2885	chlorophyll binding
HI0382	COG0823	Involved in the tonB-independent uptake of proteins
HI0383	COG3064	Membrane
HI0384	COG0848	biopolymer transport protein
HI0385	COG0811	peptide transport
HI0386	COG0824	Thioesterase
HI0387	COG1199	ATP-dependent helicase activity
HI0388	COG1214	PFAM Peptidase M22, glycoprotease
HI0389	COG3065	identical protein binding
HI0390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HI0390.1	COG0318	PFAM AMP-dependent synthetase and ligase
HI0393	COG0012	GTP binding
HI0394	COG0193	aminoacyl-tRNA hydrolase activity
HI0396	COG2850	peptidyl-arginine hydroxylation
HI0397	COG1570	exodeoxyribonuclease VII activity
HI0398	COG0494	nUDIX hydrolase
HI0399	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HI0400	COG3691	Protein conserved in bacteria
HI0401	COG2067	long-chain fatty acid transport protein
HI0402	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HI0403	COG3066	DNA modification
HI0404	COG0037	tRNA processing
HI0405	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HI0406	COG0825	malonyl-CoA metabolic process
HI0407	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI0408	COG1121	(ABC) transporter
HI0409	COG0739	heme binding
HI0410	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HI0411	COG1923	regulation of RNA biosynthetic process
HI0412	COG0564	pseudouridine synthase activity
HI0413	COG1530	ribonuclease E activity
HI0414	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HI0415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HI0416	COG0351	phosphomethylpyrimidine kinase
HI0417	COG0352	thiamine-phosphate diphosphorylase activity
HI0418	COG0477	Major facilitator Superfamily
HI0419	COG0826	peptidase U32
HI0420	COG4453	Protein conserved in bacteria
HI0422	COG0513	Belongs to the DEAD box helicase family
HI0423	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HI0424	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI0425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI0427	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HI0428	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HI0429	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI0430	COG0776	regulation of translation
HI0431	COG3068	Protein conserved in bacteria
HI0432	COG2816	NAD+ diphosphatase activity
HI0433	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HI0433	COG0316	Belongs to the HesB IscA family
HI0434	COG1040	competence protein
HI0435	COG4796	Type ii and iii secretion system protein
HI0438	COG3166	PFAM Fimbrial assembly family protein
HI0439	COG4972	Pilus assembly protein
HI0440	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HI0441	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HI0442	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HI0444	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI0445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI0446	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI0446	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI0446	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HI0447	COG1105	Belongs to the carbohydrate kinase PfkB family
HI0448	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI0448	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI0450	COG3309	Virulence-associated protein D
HI0452	COG1253	flavin adenine dinucleotide binding
HI0454	COG0084	hydrolase, TatD family'
HI0455	COG0470	DNA polymerase III
HI0456	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HI0457	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HI0458	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI0459	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HI0460	COG3956	TIGRFAM MazG family protein
HI0461	COG2990	Protein conserved in bacteria
HI0462	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HI0463	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HI0464	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HI0465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HI0466	COG0354	folic acid binding
HI0467	COG1561	YicC-like family, N-terminal region
HI0468	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HI0469	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HI0470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HI0471	COG0131	Imidazoleglycerol-phosphate dehydratase
HI0471	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HI0472	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HI0474	COG0107	imidazoleglycerol-phosphate synthase activity
HI0475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HI0475	COG0140	phosphoribosyl-ATP diphosphatase activity
HI0477	COG0814	amino acid
HI0479	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HI0480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HI0481	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HI0485.1	COG3312	ion transport
HI0488	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI0489	COG1238	metal cluster binding
HI0491	COG1854	S-ribosylhomocysteine lyase activity
HI0493	COG2801	Transposase and inactivated derivatives
HI0496	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HI0497	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HI0498	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HI0499	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HI0500	COG1322	Protein conserved in bacteria
HI0501	COG1869	D-ribose catabolic process
HI0502	COG1129	ABC transporter
HI0503	COG1172	Belongs to the binding-protein-dependent transport system permease family
HI0504	COG1879	ABC-type sugar transport system periplasmic component
HI0505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI0506	COG1609	Transcriptional regulator
HI0509	COG1575	Belongs to the MenA family. Type 1 subfamily
HI0510	COG1720	tRNA m6t6A37 methyltransferase activity
HI0511	COG1275	C4-dicarboxylate transporter malic acid transport protein
HI0513	COG0827	DNA restriction-modification system
HI0514	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HI0515	COG0085	RNA polymerase activity
HI0518	COG0813	purine-nucleoside phosphorylase activity
HI0519	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HI0520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI0521	COG1328	CTP reductase activity
HI0522	COG2364	Membrane
HI0523	COG0859	PFAM glycosyl transferase family 9
HI0524	COG0191	fructose-bisphosphate aldolase activity
HI0525	COG0126	phosphoglycerate kinase activity
HI0526	COG3719	Belongs to the RNase T2 family
HI0527	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HI0528	COG0814	amino acid
HI0529	COG1435	thymidine kinase activity
HI0530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HI0532	COG0358	DNA primase activity
HI0533	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HI0534	COG1027	Aspartate ammonia-lyase
HI0535	COG0829	nickel cation binding
HI0536	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HI0537	COG0830	nickel cation binding
HI0538	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HI0539	COG0804	urea catabolic process
HI0541	COG0831	urea catabolic process
HI0542	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HI0543	COG0459	protein refolding
HI0546	COG2965	DNA replication, synthesis of RNA primer
HI0549	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI0550	COG3306	glycosyltransferase involved in LPS biosynthesis
HI0551	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HI0553	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HI0554	COG1943	Transposase
HI0555	COG3759	membrane
HI0558	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HI0559	COG1218	3'(2'),5'-bisphosphate nucleotidase
HI0561	COG1297	OPT oligopeptide transporter protein
HI0562	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HI0563	COG1522	sequence-specific DNA binding
HI0564	COG2502	aspartate--ammonia ligase
HI0565	COG0546	phosphoglycolate phosphatase activity
HI0566	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI0567	COG0187	DNA topoisomerase II activity
HI0568	COG2183	response to ionizing radiation
HI0569	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HI0570	COG1309	transcriptional regulator
HI0571	COG0583	DNA-binding transcription factor activity
HI0572	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HI0572	COG0678	peroxiredoxin activity
HI0573	COG2900	Belongs to the SlyX family
HI0574	COG0545	Peptidyl-prolyl cis-trans isomerase
HI0575	COG2964	Protein conserved in bacteria
HI0576	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HI0576.1	COG2923	Belongs to the DsrF TusC family
HI0577	COG2168	tRNA wobble position uridine thiolation
HI0579	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HI0581	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HI0582	COG0445	tRNA wobble uridine modification
HI0583	COG0737	Belongs to the 5'-nucleotidase family
HI0584	COG1473	amidohydrolase
HI0587	COG3340	Belongs to the peptidase S51 family
HI0588	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI0589	COG3086	response to oxidative stress
HI0590	COG0531	amino acid
HI0591	COG1982	Orn Lys Arg decarboxylase major
HI0594	COG1288	antiporter activity
HI0595	COG0549	Belongs to the carbamate kinase family
HI0596	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HI0597	COG0561	phosphatase activity
HI0597.1	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HI0599	COG2137	regulation of response to DNA damage stimulus
HI0601	COG3070	regulator of competence-specific genes
HI0602	COG3071	HemY protein
HI0604	COG3072	Adenylate cyclase
HI0605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI0606	COG1045	serine acetyltransferase
HI0607	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HI0608	COG0471	metal ion transport
HI0610	COG0738	Major facilitator superfamily
HI0611	COG0235	Class ii aldolase
HI0613	COG1070	Carbohydrate kinase
HI0614	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HI0615	COG1349	DNA-binding transcription factor activity
HI0616	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HI0617	COG0564	pseudouridine synthase activity
HI0618	COG0705	Rhomboid family
HI0619	COG1349	DNA-binding transcription factor activity
HI0620	COG1464	Belongs to the NlpA lipoprotein family
HI0621	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI0621.1	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HI0622	COG0242	peptide deformylase activity
HI0623	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HI0624	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI0624	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI0625	COG0569	domain protein
HI0626	COG1970	mechanosensitive ion channel activity
HI0627	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HI0628	COG1595	DNA-templated transcription, initiation
HI0629	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HI0630	COG3026	antisigma factor binding
HI0631	COG1072	(Pantothenic acid kinase))
HI0633	COG0038	chloride channel
HI0634	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI0635	COG4771	TonB-dependent receptor
HI0635	COG1629	transport
HI0636	COG3691	Protein conserved in bacteria
HI0637	COG0180	Tryptophanyl-tRNA synthetase
HI0638	COG2915	High frequency lysogenization protein hflD homolog
HI0639	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HI0640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HI0642	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HI0643	COG0243	molybdopterin cofactor binding
HI0644	COG3005	denitrification pathway
HI0645	COG2267	carboxylic ester hydrolase activity
HI0646	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HI0647	COG1285	pathogenesis
HI0648	COG2249	NAD(P)H dehydrogenase (quinone) activity
HI0649	COG0210	DNA helicase
HI0650	COG5645	(Lipo)protein
HI0651	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HI0652	COG1519	Transferase
HI0653	COG0463	Glycosyl transferase, family 2
HI0654	COG2818	Glycosylase
HI0655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HI0656	COG0009	L-threonylcarbamoyladenylate synthase
HI0656.1	COG0551	DNA topoisomerase type I activity
HI0658	COG0488	(ABC) transporter
HI0659	COG3620	sequence-specific DNA binding
HI0660	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HI0661	COG1629	transport
HI0661	COG4771	TonB-dependent receptor
HI0663m	COG4988	ABC transporter
HI0664	COG1132	(ABC) transporter
HI0665	COG3550	peptidyl-serine autophosphorylation
HI0666	COG3550	peptidyl-serine autophosphorylation
HI0667	COG1494	fructose-1,6-bisphosphatase
HI0669	COG0716	FMN binding
HI0670	COG1490	D-aminoacyl-tRNA deacylase activity
HI0674	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HI0675	COG2195	Cleaves the N-terminal amino acid of tripeptides
HI0676	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HI0677	COG0456	acetyltransferase
HI0678	COG0149	triose-phosphate isomerase activity
HI0679	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI0680	COG2962	Rard protein
HI0681	COG0583	DNA-binding transcription factor activity
HI0683	COG0247	lactate metabolic process
HI0684	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HI0685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HI0686	COG2271	Major facilitator Superfamily
HI0687	COG0697	spore germination
HI0689	COG0584	glycerophosphoryl diester phosphodiesterase
HI0690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HI0691	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HI0692	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HI0693	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HI0694	COG1187	pseudouridine synthase activity
HI0695	COG0248	Ppx GppA phosphatase
HI0696	COG2911	Protein conserved in bacteria
HI0698	COG0729	surface antigen
HI0699	COG1047	Peptidyl-prolyl cis-trans
HI0700	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HI0701	COG0585	pseudouridine synthase activity
HI0702	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HI0703	COG1238	metal cluster binding
HI0706	COG1388	LysM domain
HI0706	COG4942	peptidase
HI0707	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HI0708	COG1921	L-seryl-tRNASec selenium transferase activity
HI0709	COG3276	selenocysteine insertion sequence binding
HI0710	COG3077	Addiction module antitoxin, RelB DinJ family
HI0711	COG3041	Addiction module toxin RelE StbE family
HI0712	COG4771	TonB-dependent receptor
HI0712	COG1629	transport
HI0713	COG0544	peptidyl-prolyl cis-trans isomerase activity
HI0714	COG0740	serine-type endopeptidase activity
HI0715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HI0716	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI0717	COG0250	Participates in transcription elongation, termination and antitermination
HI0718	COG2853	Lipoprotein
HI0719	COG0251	oxidation-reduction process
HI0721	COG0425	Belongs to the sulfur carrier protein TusA family
HI0722	COG1739	Uncharacterized protein family UPF0029
HI0723	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI0724	COG3078	GTPase activator activity
HI0726	COG2197	response regulator
HI0727	COG0019	diaminopimelate decarboxylase activity
HI0728	COG0514	ATP-dependent DNA helicase (RecQ)
HI0729	COG0442	prolyl-tRNA aminoacylation
HI0730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HI0734	COG0204	Acyl-transferase
HI0735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HI0736	COG0733	neurotransmitter:sodium symporter activity
HI0737	COG0028	Belongs to the TPP enzyme family
HI0738	COG0129	dihydroxy-acid dehydratase activity
HI0738.1	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HI0739	COG0587	DNA-directed DNA polymerase activity
HI0740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI0742	COG0702	epimerase
HI0743	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HI0744	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI0745	COG0252	asparaginase activity
HI0746	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HI0747	COG1252	NADH dehydrogenase
HI0748	COG2937	Belongs to the GPAT DAPAT family
HI0749	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HI0750	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HI0751	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HI0752	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI0752	COG0047	phosphoribosylformylglycinamidine synthase activity
HI0753	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HI0754	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HI0755	COG2861	carbohydrate metabolic process
HI0756	COG4942	peptidase
HI0757	COG0588	phosphoglycerate mutase activity
HI0759	COG1194	a g-specific adenine glycosylase
HI0761	COG0741	lytic transglycosylase activity
HI0762	COG2129	metallophosphoesterase
HI0763	COG3172	ATPase kinase involved in NAD metabolism
HI0764	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HI0765	COG3306	glycosyltransferase involved in LPS biosynthesis
HI0766	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HI0767	COG0742	ribosomal rna small subunit methyltransferase
HI0768	COG0552	protein localization to endoplasmic reticulum
HI0769	COG2884	Cell division ATP-binding protein ftsE
HI0770	COG2177	Part of the ABC transporter FtsEX involved in
HI0771	COG0183	Belongs to the thiolase family
HI0772	COG2031	fatty acid transporter
HI0773	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HI0774	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HI0775	COG0583	DNA-binding transcription factor activity
HI0776	COG0051	transcription antitermination factor activity, RNA binding
HI0777	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HI0781	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HI0783	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HI0789	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HI0796	COG1841	ribosomal large subunit assembly
HI0798	COG0201	protein transport
HI0799	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HI0800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HI0801	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HI0802	COG0202	RNA polymerase activity
HI0806	COG0730	response to heat
HI0807	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HI0809	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HI0810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HI0811	COG0165	Argininosuccinate lyase
HI0812	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HI0814	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HI0815	COG0589	response to stress
HI0816	COG0006	proline dipeptidase activity
HI0817	COG3079	Belongs to the UPF0149 family
HI0818	COG2017	converts alpha-aldose to the beta-anomer
HI0819	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI0820	COG1085	galactose-1-phosphate uridylyltransferase
HI0821	COG1609	Transcriptional regulator
HI0822	COG1879	ABC-type sugar transport system periplasmic component
HI0823	COG1129	ABC transporter
HI0824	COG4211	Belongs to the binding-protein-dependent transport system permease family
HI0826	COG2917	probably involved in intracellular septation
HI0827	COG1607	acyl-coa hydrolase
HI0828	COG2350	Protein conserved in bacteria
HI0829	COG0741	lytic transglycosylase activity
HI0831	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI0832	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HI0833	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HI0834	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HI0835	COG1053	succinate dehydrogenase
HI0836	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HI0837	COG0745	RESPONSE REGULATOR receiver
HI0838	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HI0839	COG3081	Nucleoid-associated protein
HI0840	COG3082	Protein of unknown function (DUF1414)
HI0841	COG3083	sulfuric ester hydrolase activity
HI0844	COG0746	molybdenum cofactor guanylyltransferase activity
HI0845	COG3084	Protein conserved in bacteria
HI0846	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HI0847	COG3085	chromosome segregation
HI0848	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI0849m	COG0742	ribosomal rna small subunit methyltransferase
HI0850	COG3086	response to oxidative stress
HI0851	COG1763	Mo-molybdopterin cofactor biosynthetic process
HI0852	COG2814	Major facilitator Superfamily
HI0853	COG0747	negative chemotaxis
HI0854	COG0748	coenzyme F420 binding
HI0855	COG3681	Belongs to the UPF0597 family
HI0856	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI0856	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI0858	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HI0859	COG0542	response to heat
HI0860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI0861	COG0557	exoribonuclease II activity
HI0862	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HI0863	COG0259	pyridoxamine-phosphate oxidase activity
HI0864	COG1217	gtp-binding protein TYPA
HI0865	COG0174	glutamine synthetase
HI0866	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HI0867	COG2244	polysaccharide biosynthetic process
HI0868	COG0463	Glycosyl transferase, family 2
HI0872	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI0873	COG1088	dTDP-glucose 4,6-dehydratase activity
HI0874	COG3307	-O-antigen
HI0876	COG0105	UTP biosynthetic process
HI0877	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HI0878	COG0697	spore germination
HI0879	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HI0881	COG0142	geranyltranstransferase activity
HI0882	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HI0883	COG1115	amino acid carrier protein
HI0884	COG0745	RESPONSE REGULATOR receiver
HI0885	COG4232	protein-disulfide reductase activity
HI0886	COG2259	Doxx family
HI0887	COG0138	bifunctional purine biosynthesis protein purh
HI0888	COG0151	Belongs to the GarS family
HI0889	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HI0890m	COG0237	dephospho-CoA kinase activity
HI0892	COG0513	Belongs to the DEAD box helicase family
HI0893	COG1309	transcriptional regulator
HI0894	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HI0895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HI0896	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HI0897	COG2814	Major facilitator Superfamily
HI0898	COG1566	PFAM secretion protein HlyD family protein
HI0899	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HI0900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HI0901	COG0494	nUDIX hydrolase
HI0902	COG0730	response to heat
HI0904	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HI0905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HI0906	COG0590	tRNA wobble adenosine to inosine editing
HI0907	COG4701	Protein of unknown function (DUF721)
HI0909	COG0653	protein targeting
HI0910	COG0494	nUDIX hydrolase
HI0911	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HI0911	COG0475	glutathione-regulated potassium exporter activity
HI0912	COG2226	methyltransferase
HI0915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HI0916	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HI0917	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HI0918	COG0750	zinc metalloprotease
HI0919	COG0575	Belongs to the CDS family
HI0920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HI0921	COG0495	leucyl-tRNA aminoacylation
HI0922	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HI0923	COG1466	dna polymerase III delta subunit
HI0924	COG0751	glycine-tRNA ligase activity
HI0925	COG2852	Protein conserved in bacteria
HI0926	COG4545	Glutaredoxin-related protein
HI0927	COG0752	glycyl-tRNA synthetase alpha subunit
HI0928	COG0753	catalase activity
HI0929	COG0754	glutathionylspermidine amidase activity
HI0931	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HI0933	COG2081	HI0933 family
HI0934	COG4235	cytochrome complex assembly
HI0934	COG3088	subunit of a heme lyase
HI0935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI0936	COG1138	Cytochrome C-type biogenesis protein
HI0937	COG0483	inositol monophosphate 1-phosphatase activity
HI0938	COG2165	general secretion pathway protein
HI0939	COG4795	General secretion pathway protein
HI0942	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HI0943	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HI0944	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HI0944	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HI0945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HI0946	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HI0946.1	COG0076	glutamate decarboxylase activity
HI0947	COG1487	ribonuclease activity
HI0949	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HI0952	COG2003	Belongs to the UPF0758 family
HI0953	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI0957	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI0958	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI0959	COG1472	Belongs to the glycosyl hydrolase 3 family
HI0960	COG5633	Lipoprotein
HI0961	COG0537	adenosine 5'-monophosphoramidase activity
HI0963	COG0196	riboflavin kinase activity
HI0964	COG0728	peptidoglycan biosynthetic process
HI0968	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HI0969	COG1441	menaquinone biosynthetic process
HI0970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HI0971	COG0511	ligase activity, forming carbon-carbon bonds
HI0972	COG0439	Biotin carboxylase
HI0973	COG3266	domain, Protein
HI0974.1	COG3924	membrane
HI0975	COG4145	pantothenate transmembrane transporter activity
HI0977	COG2184	nucleotidyltransferase activity
HI0978	COG2264	protein methyltransferase activity
HI0979	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI0984	COG3022	response to hydroperoxide
HI0985	COG0758	DNA mediated transformation
HI0986	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HI0987	COG0473	3-isopropylmalate dehydrogenase activity
HI0988	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HI0989	COG0066	3-isopropylmalate dehydratase activity
HI0990	COG3468	outer membrane autotransporter barrel domain protein
HI0990	COG3266	domain, Protein
HI0991	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HI0992	COG0592	DNA-directed DNA polymerase activity
HI0993	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI0994	COG1629	transport
HI0994	COG4771	TonB-dependent receptor
HI0999	COG0594	ribonuclease P activity
HI1001	COG0706	membrane insertase activity
HI1002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HI1005	COG2194	sulfuric ester hydrolase activity
HI1006	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HI1007	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HI1008	COG1555	photosystem II stabilization
HI1009	COG1349	DNA-binding transcription factor activity
HI1010	COG2084	Dehydrogenase
HI1011	COG3395	kinase activity
HI1012	COG0235	Class ii aldolase
HI1013	COG3622	Belongs to the hyi family
HI1014	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI1015	COG2610	gluconate transmembrane transporter activity
HI1016	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HI1017	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HI1019	COG4143	(ABC) transporter
HI1020	COG1178	ABC-type Fe3 transport system permease component
HI1021	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HI1023	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HI1024	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HI1025	COG0235	Class ii aldolase
HI1026	COG3623	hexulose-6-phosphate isomerase
HI1027	COG1070	Carbohydrate kinase
HI1028	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HI1029	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HI1030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HI1031	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HI1032	COG1414	Transcriptional regulator
HI1033	COG0560	Phosphoserine phosphatase
HI1035	COG0598	Magnesium transport protein CorA
HI1036	COG0762	integral membrane protein
HI1037	COG0121	glutamine amidotransferase
HI1038	COG1373	ATPase (AAA superfamily
HI1041	COG0270	DNA (cytosine-5-)-methyltransferase activity
HI1043	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HI1043	COG2221	Nitrite and sulphite reductase 4Fe-4S
HI1044	COG3381	protein complex oligomerization
HI1045	COG3302	dmso reductase anchor subunit
HI1046	COG0437	4 iron, 4 sulfur cluster binding
HI1047	COG0243	molybdopterin cofactor binding
HI1048	COG1305	Transglutaminase-like
HI1050	COG2608	mercury ion transmembrane transporter activity
HI1051	COG1132	(ABC) transporter
HI1052	COG4977	sequence-specific DNA binding
HI1052	COG1917	Cupin 2, conserved barrel domain protein
HI1053	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HI1056	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HI1058	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HI1059	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI1060	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HI1061	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HI1062	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI1065	COG0528	UMP kinase activity
HI1066	COG3301	Polysulphide reductase, NrfD
HI1067	COG0437	4 iron, 4 sulfur cluster binding
HI1068	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HI1069	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HI1070	COG1643	Atp-dependent helicase
HI1073	COG2363	Small membrane protein
HI1074	COG2707	UPF0756 membrane protein
HI1075	COG1294	oxidase, subunit
HI1076	COG1271	oxidase subunit
HI1077	COG0504	CTP synthase activity
HI1078	COG1126	abc transporter atp-binding protein
HI1079m	COG0765	amino acid transport
HI1080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI1081	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI1082	COG5007	Belongs to the BolA IbaG family
HI1083	COG3113	response to antibiotic
HI1084	COG2854	intermembrane phospholipid transfer
HI1085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HI1086	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HI1087	COG1127	ABC transporter
HI1088	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HI1089	COG4133	protoheme IX ABC transporter activity
HI1090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HI1091	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HI1092	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HI1093	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HI1094	COG1138	Cytochrome C-type biogenesis protein
HI1095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI1100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI1101	COG3115	cell septum assembly
HI1102	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HI1103	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI1104	COG2814	Major facilitator Superfamily
HI1105	COG0859	PFAM glycosyl transferase family 9
HI1106	COG1609	Transcriptional regulator
HI1106	COG2207	Transcriptional regulator
HI1107	COG1757	Na H antiporter
HI1109	COG4214	carbohydrate transport
HI1110	COG1129	ABC transporter
HI1111	COG4213	ABC transporter substrate-binding protein
HI1113	COG1070	Carbohydrate kinase
HI1114	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI1115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI1116	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HI1117	COG0606	chelatase, subunit chli
HI1119	COG2990	Protein conserved in bacteria
HI1120	COG4608	Belongs to the ABC transporter superfamily
HI1121	COG0444	Belongs to the ABC transporter superfamily
HI1122	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HI1123	COG0601	transmembrane transport
HI1124	COG4166	transmembrane transport
HI1125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HI1130	COG0275	rRNA processing
HI1131	COG3116	cell division
HI1132	COG0768	penicillin binding
HI1133	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HI1134	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI1135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HI1136	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HI1137	COG0772	Belongs to the SEDS family
HI1138	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HI1139	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HI1140	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI1141	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HI1142	COG0849	cell division
HI1143	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HI1144	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HI1145	COG1605	Chorismate mutase
HI1145	COG0077	Prephenate dehydratase
HI1146	COG1660	Displays ATPase and GTPase activities
HI1147	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI1148	COG1137	ATPase activity
HI1149m	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HI1150	COG3117	lipopolysaccharide transmembrane transporter activity
HI1152	COG0312	modulator of DNA gyrase
HI1153	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HI1154	COG1823	symporter activity
HI1155	COG0602	queuosine metabolic process
HI1156	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HI1157	COG4988	ABC transporter
HI1158	COG0492	ferredoxin-NADP+ reductase activity
HI1160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HI1161	COG2050	protein possibly involved in aromatic compounds catabolism
HI1162	COG2852	Protein conserved in bacteria
HI1163	COG0277	FAD linked oxidase domain protein
HI1163	COG0247	lactate metabolic process
HI1164	COG2885	chlorophyll binding
HI1164	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HI1165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HI1166	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HI1167	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HI1168a	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HI1169	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HI1171	COG0512	Glutamine amidotransferase of anthranilate synthase
HI1172	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HI1173	COG3091	SprT-like family
HI1174	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HI1177	COG4160	amino acid transport
HI1178	COG4215	(ABC) transporter
HI1179	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI1180	COG1126	abc transporter atp-binding protein
HI1181	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HI1184	COG4608	Belongs to the ABC transporter superfamily
HI1185	COG0444	Belongs to the ABC transporter superfamily
HI1186	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HI1187	COG0601	transmembrane transport
HI1188	COG0210	DNA helicase
HI1189	COG0602	queuosine metabolic process
HI1190	COG0720	synthase
HI1193	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HI1194m	COG0583	DNA-binding transcription factor activity
HI1195m	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HI1196	COG0045	succinate-CoA ligase (ADP-forming) activity
HI1197	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HI1198	COG0009	L-threonylcarbamoyladenylate synthase
HI1199	COG1187	pseudouridine synthase activity
HI1200	COG0583	DNA-binding transcription factor activity
HI1201	COG2890	protein-(glutamine-N5) methyltransferase activity
HI1202	COG2840	Smr protein MutS2
HI1203	COG0280	phosphate acetyltransferase
HI1203	COG0857	belongs to the CobB CobQ family
HI1204	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HI1205	COG3092	negative regulation of chromosome organization
HI1206	COG1286	toxin biosynthetic process
HI1207	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HI1208	COG1090	epimerase
HI1209	COG1438	arginine binding
HI1210	COG0039	L-malate dehydrogenase activity
HI1211	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HI1213	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HI1214	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HI1215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HI1216	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HI1217	COG1629	transport
HI1217	COG4206	TonB-dependent receptor
HI1218	COG1620	l-lactate permease
HI1219	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HI1220	COG0539	negative regulation of cytoplasmic translation
HI1221	COG0776	regulation of translation
HI1222	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HI1223	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HI1224	COG0284	orotidine-5'-phosphate decarboxylase activity
HI1225	COG0023	Translation Initiation Factor
HI1225.1	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI1227	COG2233	PERMEase
HI1229	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HI1231	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI1232	COG0508	dehydrogenase complex catalyzes the overall conversion of
HI1233	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HI1234	COG1803	Methylglyoxal synthase
HI1237	COG0443	Heat shock 70 kDa protein
HI1238	COG0484	heat shock protein binding
HI1239	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HI1240	COG2860	membrane
HI1242	COG2814	Major facilitator Superfamily
HI1243	COG1187	pseudouridine synthase activity
HI1244	COG3955	Domain of unknown function (DUF1919)
HI1245	COG0280	phosphate acetyltransferase
HI1245	COG0281	malic enzyme
HI1246	COG1368	sulfuric ester hydrolase activity
HI1247	COG0556	nucleotide-excision repair
HI1248	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HI1249	COG3683	transport system, periplasmic component
HI1250	COG3549	Plasmid maintenance system killer
HI1251	COG3093	addiction module antidote protein HigA
HI1252	COG0488	(ABC) transporter
HI1253	COG3094	Invasion gene expression up-regulator, SirB
HI1258	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HI1259	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HI1261	COG0285	dihydrofolate synthase activity
HI1262	COG2949	membrane
HI1263	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HI1264	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HI1265	COG1944	ATP diphosphatase activity
HI1272	COG1120	ATPase activity
HI1273	COG0500	methyltransferase
HI1274	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HI1275	COG3615	Tellurite resistance protein tehB
HI1275	COG0500	methyltransferase
HI1276	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI1276	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI1277	COG0489	protein tyrosine kinase activity
HI1278	COG0778	Nitroreductase
HI1279	COG1083	cytidylyl-transferase
HI1283	COG0195	Participates in both transcription termination and antitermination
HI1284	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HI1285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HI1286	COG0732	type I restriction modification DNA specificity domain
HI1287	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HI1288	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HI1289	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HI1290	COG0287	Prephenate dehydrogenase
HI1290	COG1605	Chorismate mutase
HI1291	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HI1291	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HI1292	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HI1293	COG2166	iron-sulfur cluster assembly
HI1295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI1296	COG1525	nuclease
HI1297	COG1380	Effector of murein hydrolase LrgA
HI1298	COG1346	cytolysis
HI1300	COG0488	(ABC) transporter
HI1301	COG0288	reversible hydration of carbon dioxide
HI1302	COG0017	Asparaginyl-tRNA synthetase
HI1303	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HI1305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HI1306	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HI1307	COG1280	lysine exporter protein (LysE YggA)
HI1308	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HI1309	COG0633	Ferredoxin
HI1311	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HI1312	COG0072	phenylalanine-tRNA ligase activity
HI1312	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI1313	COG0776	regulation of translation
HI1314	COG0791	NLP P60 protein
HI1315	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HI1316	COG3119	arylsulfatase activity
HI1317	COG0676	glucose-6-phosphate 1-epimerase activity
HI1319m	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HI1320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HI1321	COG1074	ATP-dependent DNA helicase activity
HI1322	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HI1324	COG1067	ATP-dependent peptidase activity
HI1326	COG0515	serine threonine protein kinase
HI1330	COG2027	D-alanyl-D-alanine carboxypeptidase
HI1331	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HI1333	COG1534	Rna-binding protein
HI1334	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HI1335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HI1336	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HI1337	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI1338	COG2062	phosphohistidine phosphatase, SixA
HI1340	COG1538	Outer membrane efflux protein
HI1340	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HI1340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HI1341	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HI1342	COG0488	(ABC) transporter
HI1343	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI1344	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HI1345	COG1177	transmembrane transport
HI1346	COG1176	ABC-type spermidine putrescine transport system, permease component I
HI1347	COG3842	ATPase activity
HI1348	COG2195	Cleaves the N-terminal amino acid of tripeptides
HI1349	COG0783	Belongs to the Dps family
HI1350	COG0295	cytidine deaminase activity
HI1351	COG0500	methyltransferase
HI1352	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HI1353	COG1530	ribonuclease E activity
HI1354	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HI1355	COG2983	Belongs to the UPF0260 family
HI1356	COG1640	4-alpha-glucanotransferase
HI1357	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HI1358	COG1523	belongs to the glycosyl hydrolase 13 family
HI1359	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HI1360	COG0297	glycogen (starch) synthase activity
HI1361	COG0058	SHG alpha-glucan phosphorylase activity
HI1362	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HI1363	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HI1364	COG0583	DNA-binding transcription factor activity
HI1365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI1366	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HI1367	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HI1368	COG0612	Peptidase, M16
HI1369	COG4771	TonB-dependent receptor
HI1370	COG3585	molybdate ion transport
HI1371	COG2920	part of a sulfur-relay system
HI1371.1	COG0037	tRNA processing
HI1372	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HI1373	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HI1374	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HI1375	COG3586	endonuclease activity
HI1376	COG0697	spore germination
HI1377	COG2925	Exonuclease
HI1378	COG5002	protein histidine kinase activity
HI1379	COG0745	RESPONSE REGULATOR receiver
HI1381	COG0581	inorganic phosphate transmembrane transporter activity
HI1382	COG0573	inorganic phosphate transmembrane transporter activity
HI1384	COG1528	Iron-storage protein
HI1385	COG1528	Iron-storage protein
HI1387	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HI1388	COG0512	Glutamine amidotransferase of anthranilate synthase
HI1388.1	COG1942	4-Oxalocrotonate Tautomerase
HI1389	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HI1389.1	COG0134	indole-3-glycerol-phosphate synthase activity
HI1389.1	COG0135	phosphoribosylanthranilate isomerase activity
HI1391	COG0525	valine-tRNA ligase activity
HI1392	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HI1394	COG3097	Belongs to the UPF0267 family
HI1397	COG2927	DNA polymerase III (CHI subunit)
HI1398	COG0114	fumarate hydratase activity
HI1399	COG2268	Band 7 protein
HI1400	COG0613	PHP domain protein
HI1401	COG0167	dihydroorotate dehydrogenase activity
HI1403	COG5301	cellulose 1,4-beta-cellobiosidase activity
HI1405	COG3566	protein conserved in bacteria
HI1407	COG2369	cell adhesion
HI1409	COG3567	Phage-associated protein, HI1409 family
HI1410	COG1783	phage Terminase large subunit
HI1411	COG3728	DNA packaging
HI1412	COG3646	Phage regulatory protein
HI1415	COG3179	chitinase
HI1418	COG3617	BRO family, N-terminal domain
HI1419	COG3657	addiction module killer protein
HI1420	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HI1422	COG3561	AntA/AntB antirepressor
HI1424	COG0582	viral genome integration into host DNA
HI1425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI1426	COG0589	response to stress
HI1427	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HI1428	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HI1429	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HI1430	COG4221	oxidoreductase activity
HI1431	COG0133	tryptophan synthase activity
HI1432	COG0159	tryptophan synthase activity
HI1433	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HI1434	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HI1434.1	COG1278	Cold shock
HI1436	COG3098	single-species biofilm formation
HI1437	COG1722	exodeoxyribonuclease VII activity
HI1438	COG0142	geranyltranstransferase activity
HI1439	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HI1440	COG2969	positive regulation of protein catabolic process
HI1441	COG0625	glutathione transferase activity
HI1444	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HI1445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HI1446	COG3100	YcgL domain-containing protein
HI1447	COG0302	gtp cyclohydrolase
HI1448	COG0303	'Molybdopterin
HI1449	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HI1450	COG3099	Belongs to the UPF0263 family
HI1452	COG2431	L-lysine efflux transmembrane transporter activity
HI1453	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI1454	COG0785	Cytochrome C biogenesis protein
HI1455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI1455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI1457	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HI1459	COG1595	DNA-templated transcription, initiation
HI1462	COG1538	Outer membrane efflux protein
HI1462.2	COG2062	phosphohistidine phosphatase, SixA
HI1463	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI1464	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HI1465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HI1467	COG4178	(ABC) transporter
HI1470	COG1120	ATPase activity
HI1471	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI1472	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HI1473	COG0157	Belongs to the NadC ModD family
HI1474	COG3842	ATPase activity
HI1475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HI1476	COG2932	Transcriptional regulator
HI1477	COG3423	Transcriptional regulator
HI1478	COG2801	Transposase and inactivated derivatives
HI1481	COG2842	Transposition protein
HI1483	COG4396	Host-nuclease inhibitor protein Gam
HI1485	COG4396	Host-nuclease inhibitor protein Gam
HI1488	COG4382	Mu-like prophage protein Gp16
HI1493	COG3023	N-Acetylmuramoyl-L-alanine amidase
HI1497	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HI1498.1	COG0640	Transcriptional regulator
HI1500	COG4373	Mu-like prophage FluMu protein gp28
HI1501	COG4383	Mu-like prophage protein gp29
HI1502	COG2369	cell adhesion
HI1503	COG5005	Phage virion morphogenesis
HI1504	COG4388	Caudovirus prohead serine protease
HI1505	COG4397	Mu-like prophage major head subunit gpT
HI1508	COG4387	Mu-like prophage protein GP36
HI1509	COG5003	unkown
HI1511	COG4386	tail sheath protein
HI1513	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HI1514	COG3941	tape measure
HI1515	COG4228	DNA circulation
HI1518	COG4384	Bacteriophage Mu Gp45 protein
HI1519	COG4381	Mu-like prophage protein gp46
HI1520	COG3299	homolog of phage Mu protein gp47
HI1521	COG3778	Protein conserved in bacteria
HI1522	COG5301	cellulose 1,4-beta-cellobiosidase activity
HI1522.1	COG4416	COG NOG18757 non supervised orthologous group
HI1523	COG3392	D12 class N6 adenine-specific DNA methyltransferase
HI1525	COG0725	ABC transporter, periplasmic molybdate-binding protein
HI1526	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HI1526	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HI1527	COG1560	Kdo2-lipid A biosynthetic process
HI1528	COG0187	DNA topoisomerase II activity
HI1529	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HI1530	COG0786	glutamate:sodium symporter activity
HI1531	COG0189	ligase activity
HI1532	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HI1533	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HI1537	COG0510	thiamine kinase activity
HI1538	COG0697	spore germination
HI1539	COG4750	Nucleotidyl transferase
HI1540	COG3475	LICD family
HI1541	COG0616	signal peptide processing
HI1542	COG0778	Nitroreductase
HI1543	COG3381	protein complex oligomerization
HI1544	COG2249	NAD(P)H dehydrogenase (quinone) activity
HI1545	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HI1546	COG2932	Transcriptional regulator
HI1547	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HI1548	COG4591	ABC-type transport system involved in lipoprotein release permease component
HI1549	COG1136	(ABC) transporter
HI1550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HI1551	COG0500	methyltransferase
HI1552	COG2830	Protein of unknown function (DUF452)
HI1553	COG0156	8-amino-7-oxononanoate synthase activity
HI1554	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HI1555	COG4591	ABC-type transport system involved in lipoprotein release permease component
HI1556	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HI1557	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HI1558	COG2912	Transglutaminase-like superfamily
HI1559	COG2890	protein-(glutamine-N5) methyltransferase activity
HI1560	COG1714	RDD family
HI1561	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HI1563	COG3101	peptidyl-lysine hydroxylation
HI1564	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI1568	COG5005	Phage virion morphogenesis
HI1571	COG4383	Mu-like prophage protein gp29
HI1573	COG0469	pyruvate kinase activity
HI1574	COG0305	Participates in initiation and elongation during chromosome replication
HI1575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HI1576	COG0166	Belongs to the GPI family
HI1578	COG1216	Glycosyl transferase, family 2
HI1579	COG3133	Outer membrane lipoprotein
HI1583	COG0018	arginyl-trna synthetase
HI1584	COG0440	acetolactate synthase activity
HI1585	COG0028	Belongs to the TPP enzyme family
HI1586	COG1757	Na H antiporter
HI1587	COG2916	Histone family protein nucleoid-structuring protein H-NS
HI1588	COG0788	formyltetrahydrofolate deformylase activity
HI1589	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HI1590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HI1591	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HI1596	COG1522	sequence-specific DNA binding
HI1597	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HI1598	COG3025	triphosphatase activity
HI1599	COG3219	Protein conserved in bacteria
HI1600	COG3220	belongs to the UPF0276 family
HI1602	COG2259	Doxx family
HI1603	COG1392	Phosphate transport regulator
HI1604	COG0306	phosphate transporter
HI1605	COG4991	sh3 domain protein
HI1606	COG0617	tRNA 3'-terminal CCA addition
HI1607	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HI1608	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HI1609	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI1610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HI1611	COG1489	DNA binding
HI1612	COG0534	Mate efflux family protein
HI1613	COG0307	riboflavin synthase, alpha
HI1614	COG0308	aminopeptidase N
HI1615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HI1616	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HI1617	COG1448	Aminotransferase
HI1617.1	COG0309	Hydrogenase expression formation protein (HypE)
HI1618	COG1122	ATPase activity
HI1621	COG0310	cobalt ion transport
HI1622	COG0310	cobalt ion transport
HI1623	COG0789	Transcriptional regulator
HI1624	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HI1625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HI1627	COG0251	oxidation-reduction process
HI1628	COG3105	Protein conserved in bacteria
HI1629	COG0586	Pfam SNARE associated Golgi protein
HI1630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HI1632	COG0527	aspartate kinase activity
HI1633	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HI1635	COG1609	Transcriptional regulator
HI1636	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HI1637	COG3106	COG3106 Predicted ATPase
HI1638	COG4166	transmembrane transport
HI1639	COG4168	peptide transport system, permease
HI1640	COG4171	peptide transport system, permease
HI1641	COG4172	Belongs to the ABC transporter superfamily
HI1642	COG4172	Belongs to the ABC transporter superfamily
HI1643	COG2855	membrane
HI1644	COG0101	tRNA pseudouridine synthase activity
HI1645	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HI1646m	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HI1649	COG0277	FAD linked oxidase domain protein
HI1651	COG2198	Histidine kinase
HI1652	COG0791	NLP P60 protein
HI1654	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HI1655	COG3107	peptidoglycan biosynthetic process
HI1656	COG0792	nuclease activity
HI1657	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HI1658	COG2823	Periplasmic or secreted lipoprotein
HI1659	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HI1660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HI1661	COG0508	dehydrogenase complex catalyzes the overall conversion of
HI1662	COG0567	Dehydrogenase, E1 component
HI1663	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HI1664	COG0084	hydrolase, TatD family'
HI1667	COG2989	Protein conserved in bacteria
HI1668	COG0793	Belongs to the peptidase S41A family
HI1670	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HI1671	COG2995	paraquat-inducible protein a
HI1672	COG3008	intermembrane lipid transfer
HI1673	COG0314	molybdopterin synthase activity
HI1674	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HI1675	COG0315	cyclic pyranopterin monophosphate synthase activity
HI1676	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HI1677	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HI1678	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HI1678	COG0517	IMP dehydrogenase activity
HI1679	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HI1680	COG1289	transmembrane transporter activity
HI1682	COG0616	signal peptide processing
HI1683	COG4657	Part of a membrane complex involved in electron transport
HI1685	COG4656	Part of a membrane complex involved in electron transport
HI1686	COG4658	electron transport chain
HI1687	COG4659	FMN binding
HI1688	COG4660	Part of a membrane complex involved in electron transport
HI1689	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HI1690	COG0733	neurotransmitter:sodium symporter activity
HI1691	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HI1692	COG4149	molybdate abc transporter
HI1693	COG0725	ABC transporter, periplasmic molybdate-binding protein
HI1694	COG2005	Transcriptional regulator
HI1695	COG1216	Glycosyl transferase, family 2
HI1696	COG1216	Glycosyl transferase, family 2
HI1697	COG3306	glycosyltransferase involved in LPS biosynthesis
HI1698	COG0438	transferase activity, transferring glycosyl groups
HI1700	COG2244	polysaccharide biosynthetic process
HI1701	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HI1702	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI1703	COG0795	lipopolysaccharide-transporting ATPase activity
HI1704	COG0795	lipopolysaccharide-transporting ATPase activity
HI1705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HI1706	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HI1707	COG0642	Histidine kinase
HI1708	COG0745	RESPONSE REGULATOR receiver
HI1709	COG3111	PFAM Bacterial OB fold (BOF) protein
HI1711	COG2190	(PTS) system
HI1712	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI1713	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI1714	COG1162	GTPase activity
HI1715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HI1716	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HI1719	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HI1720	COG2963	transposase activity
HI1721	COG2801	Transposase and inactivated derivatives
HI1722	COG0024	Methionine aminopeptidase
HI1723	COG0316	Belongs to the HesB IscA family
HI1724	COG3112	Uncharacterised protein family (UPF0231)
HI1725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI1726	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HI1728	COG1914	H( )-stimulated, divalent metal cation uptake system
HI1729m	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HI1730	COG1984	allophanate hydrolase subunit 2
HI1731	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HI1733	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HI1734	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HI1735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HI1737	COG1687	branched-chain amino acid
HI1738	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HI1739	COG0583	DNA-binding transcription factor activity
HI1739.1	COG1304	FMN binding
HI1739.2	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HI1740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HI1741	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HI1742	COG1758	RNA polymerase activity
HI1743	COG0194	GDP metabolic process