locus-tag	class	description
INP99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INP99_RS00010	COG0592	DNA-directed DNA polymerase activity
INP99_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INP99_RS00020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INP99_RS00025	COG0363	glucosamine-6-phosphate deaminase activity
INP99_RS00030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INP99_RS00035	COG1737	Transcriptional regulator
INP99_RS00045	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INP99_RS00050	COG2190	(PTS) system
INP99_RS00050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP99_RS00050	COG1263	PTS System
INP99_RS00055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INP99_RS00075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
INP99_RS00085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INP99_RS00100	COG1811	Na channel or pump
INP99_RS00115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INP99_RS00120	COG0437	4 iron, 4 sulfur cluster binding
INP99_RS00125	COG3301	Polysulphide reductase, NrfD
INP99_RS00130	COG1138	Cytochrome C-type biogenesis protein
INP99_RS00135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INP99_RS00140	COG4235	cytochrome complex assembly
INP99_RS00140	COG3088	subunit of a heme lyase
INP99_RS00145	COG2081	HI0933 family
INP99_RS00150	COG2267	carboxylic ester hydrolase activity
INP99_RS00165	COG1169	isochorismate synthase
INP99_RS00170	COG0436	Aminotransferase
INP99_RS00175	COG4589	Belongs to the CDS family
INP99_RS00185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INP99_RS00200	COG0681	Belongs to the peptidase S26 family
INP99_RS00205	COG0481	GTPase activity
INP99_RS00225	COG0590	tRNA wobble adenosine to inosine editing
INP99_RS00240	COG0730	response to heat
INP99_RS00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
INP99_RS00255	COG4969	Belongs to the N-Me-Phe pilin family
INP99_RS00260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
INP99_RS00265	COG1459	type II secretion system
INP99_RS00270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
INP99_RS00275	COG0237	dephospho-CoA kinase activity
INP99_RS00290	COG0513	Belongs to the DEAD box helicase family
INP99_RS00295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
INP99_RS00300	COG1792	Involved in formation and maintenance of cell shape
INP99_RS00305	COG1077	Cell shape determining protein MreB Mrl
INP99_RS00310	COG4178	(ABC) transporter
INP99_RS00320	COG0799	negative regulation of ribosome biogenesis
INP99_RS00330	COG0768	penicillin binding
INP99_RS00335	COG0772	Belongs to the SEDS family
INP99_RS00340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
INP99_RS00340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
INP99_RS00345	COG1686	Belongs to the peptidase S11 family
INP99_RS00375	COG2814	Major facilitator Superfamily
INP99_RS00380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INP99_RS00390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
INP99_RS00395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
INP99_RS00400	COG0789	Transcriptional regulator
INP99_RS00405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INP99_RS00410	COG2252	PERMEase
INP99_RS00415	COG0826	peptidase U32
INP99_RS00450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INP99_RS00455	COG0343	queuine tRNA-ribosyltransferase activity
INP99_RS00460	COG3945	hemerythrin HHE cation binding domain
INP99_RS00465	COG0425	Belongs to the sulfur carrier protein TusA family
INP99_RS00470	COG1862	Preprotein translocase
INP99_RS00475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INP99_RS00480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INP99_RS00485	COG0628	permease
INP99_RS00490	COG0347	Belongs to the P(II) protein family
INP99_RS00495	COG0521	Mo-molybdopterin cofactor biosynthetic process
INP99_RS00500	COG0542	response to heat
INP99_RS00505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INP99_RS00515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INP99_RS00520	COG0564	pseudouridine synthase activity
INP99_RS00525	COG1496	oxidoreductase activity
INP99_RS00540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
INP99_RS00590	COG0151	Belongs to the GarS family
INP99_RS00595	COG0138	bifunctional purine biosynthesis protein purh
INP99_RS00600	COG2259	Doxx family
INP99_RS00605	COG4232	protein-disulfide reductase activity
INP99_RS00610	COG0745	RESPONSE REGULATOR receiver
INP99_RS00625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INP99_RS00630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INP99_RS00635	COG0697	spore germination
INP99_RS00650	COG0142	geranyltranstransferase activity
INP99_RS00655	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INP99_RS00665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INP99_RS00665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INP99_RS00680	COG2391	methyltransferase activity
INP99_RS00685	COG0425	Belongs to the sulfur carrier protein TusA family
INP99_RS00690	COG2731	YhcH YjgK YiaL family protein
INP99_RS00700	COG4785	May be involved in cell division
INP99_RS00705	COG0513	Belongs to the DEAD box helicase family
INP99_RS00710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INP99_RS00720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INP99_RS00725	COG1115	amino acid carrier protein
INP99_RS00730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INP99_RS00740	COG0560	Phosphoserine phosphatase
INP99_RS00760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
INP99_RS00765	COG0335	large ribosomal subunit rRNA binding
INP99_RS00785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INP99_RS00795	COG0805	protein transport
INP99_RS00810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INP99_RS00815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INP99_RS00835	COG2991	Protein conserved in bacteria
INP99_RS00840	COG1477	protein flavinylation
INP99_RS00845	COG2871	sodium ion transport
INP99_RS00850	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INP99_RS00860	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INP99_RS00875	COG0271	Belongs to the BolA IbaG family
INP99_RS00880	COG3056	Lipoprotein
INP99_RS00885	COG0598	Magnesium transport protein CorA
INP99_RS00890	COG0762	integral membrane protein
INP99_RS00895	COG1872	DUF167
INP99_RS00905	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
INP99_RS00910	COG1466	dna polymerase III delta subunit
INP99_RS00915	COG1368	sulfuric ester hydrolase activity
INP99_RS00920	COG0494	nUDIX hydrolase
INP99_RS00935	COG4701	Protein of unknown function (DUF721)
INP99_RS00940	COG0338	D12 class N6 adenine-specific DNA methyltransferase
INP99_RS00945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INP99_RS00955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INP99_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
INP99_RS00970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INP99_RS00990	COG1399	metal-binding, possibly nucleic acid-binding protein
INP99_RS00995	COG1132	(ABC) transporter
INP99_RS01000	COG4977	sequence-specific DNA binding
INP99_RS01000	COG1917	Cupin 2, conserved barrel domain protein
INP99_RS01005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
INP99_RS01010	COG0859	PFAM glycosyl transferase family 9
INP99_RS01035	COG0751	glycine-tRNA ligase activity
INP99_RS01045	COG2852	Protein conserved in bacteria
INP99_RS01065	COG4545	Glutaredoxin-related protein
INP99_RS01080	COG4206	TonB-dependent receptor
INP99_RS01100	COG0105	UTP biosynthetic process
INP99_RS01110	COG1088	dTDP-glucose 4,6-dehydratase activity
INP99_RS01115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INP99_RS01135	COG1442	glycosyl transferase family 8
INP99_RS01155	COG0174	glutamine synthetase
INP99_RS01160	COG1217	gtp-binding protein TYPA
INP99_RS01170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INP99_RS01175	COG2814	Major facilitator Superfamily
INP99_RS01180	COG4974	Belongs to the 'phage' integrase family
INP99_RS01185	COG1929	Belongs to the glycerate kinase type-1 family
INP99_RS01190	COG2610	gluconate transmembrane transporter activity
INP99_RS01195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INP99_RS01200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INP99_RS01220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INP99_RS01225	COG1381	Involved in DNA repair and RecF pathway recombination
INP99_RS01235	COG3266	domain, Protein
INP99_RS01235	COG3061	Opacity-associated protein A
INP99_RS01240	COG1509	lysine 2,3-aminomutase activity
INP99_RS01255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP99_RS01260	COG1882	Formate acetyltransferase
INP99_RS01265	COG2116	formate transmembrane transporter activity
INP99_RS01270	COG1555	photosystem II stabilization
INP99_RS01280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INP99_RS01300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INP99_RS01325	COG1216	Glycosyl transferase, family 2
INP99_RS01340	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
INP99_RS01345	COG1011	Hydrolase
INP99_RS01355	COG0754	glutathionylspermidine amidase activity
INP99_RS01360	COG1979	alcohol dehydrogenase
INP99_RS01375	COG0250	Participates in transcription elongation, termination and antitermination
INP99_RS01380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INP99_RS01385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INP99_RS01400	COG1652	LysM domain
INP99_RS01405	COG2321	neutral zinc metallopeptidase
INP99_RS01415	COG0196	riboflavin kinase activity
INP99_RS01420	COG0728	peptidoglycan biosynthetic process
INP99_RS01430	COG0557	exoribonuclease II activity
INP99_RS01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INP99_RS01440	COG1114	Component of the transport system for branched-chain amino acids
INP99_RS01445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INP99_RS01450	COG1215	transferase activity, transferring glycosyl groups
INP99_RS01465	COG1566	PFAM secretion protein HlyD family protein
INP99_RS01470	COG2814	Major facilitator Superfamily
INP99_RS01475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INP99_RS01480	COG0629	single-stranded DNA binding
INP99_RS01485	COG2132	Multicopper oxidase
INP99_RS01500	COG2116	formate transmembrane transporter activity
INP99_RS01545	COG0514	ATP-dependent DNA helicase (RecQ)
INP99_RS01550	COG0758	DNA mediated transformation
INP99_RS01570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP99_RS01570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP99_RS01575	COG3715	PTS system
INP99_RS01580	COG3716	PTS system mannose fructose sorbose family IID component
INP99_RS01600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INP99_RS01605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INP99_RS01605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INP99_RS01615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
INP99_RS01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INP99_RS01625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INP99_RS01630	COG1120	ATPase activity
INP99_RS01640	COG1649	PFAM Uncharacterised BCR, COG1649
INP99_RS01640	COG0726	polysaccharide deacetylase
INP99_RS01645	COG1215	transferase activity, transferring glycosyl groups
INP99_RS01675	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
INP99_RS01675	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
INP99_RS01675	COG0506	proline dehydrogenase activity
INP99_RS01685	COG2801	Transposase and inactivated derivatives
INP99_RS01690	COG2963	transposase activity
INP99_RS01720	COG0859	PFAM glycosyl transferase family 9
INP99_RS01725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INP99_RS01730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INP99_RS01740	COG0738	Major facilitator superfamily
INP99_RS01745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INP99_RS01750	COG1349	DNA-binding transcription factor activity
INP99_RS01765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INP99_RS01780	COG0641	radical SAM
INP99_RS01785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INP99_RS01790	COG3119	arylsulfatase activity
INP99_RS01795	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INP99_RS01800	COG0730	response to heat
INP99_RS01805	COG3956	TIGRFAM MazG family protein
INP99_RS01845	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
INP99_RS01850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INP99_RS01855	COG1739	Uncharacterized protein family UPF0029
INP99_RS01885	COG3276	selenocysteine insertion sequence binding
INP99_RS01890	COG1921	L-seryl-tRNASec selenium transferase activity
INP99_RS01915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INP99_RS01925	COG0038	chloride channel
INP99_RS01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INP99_RS01940	COG3172	ATPase kinase involved in NAD metabolism
INP99_RS01945	COG2129	metallophosphoesterase
INP99_RS01965	COG0210	DNA helicase
INP99_RS01970	COG5645	(Lipo)protein
INP99_RS01980	COG1519	Transferase
INP99_RS01985	COG0463	Glycosyl transferase, family 2
INP99_RS01990	COG4783	chaperone-mediated protein folding
INP99_RS02000	COG2861	carbohydrate metabolic process
INP99_RS02005	COG4942	peptidase
INP99_RS02020	COG1187	pseudouridine synthase activity
INP99_RS02025	COG3468	outer membrane autotransporter barrel domain protein
INP99_RS02035	COG0583	DNA-binding transcription factor activity
INP99_RS02040	COG2962	Rard protein
INP99_RS02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
INP99_RS02065	COG0488	(ABC) transporter
INP99_RS02070	COG0551	DNA topoisomerase type I activity
INP99_RS02080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INP99_RS02085	COG2818	Glycosylase
INP99_RS02095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
INP99_RS02100	COG0456	acetyltransferase
INP99_RS02110	COG2197	response regulator
INP99_RS02115	COG3072	Adenylate cyclase
INP99_RS02120	COG0181	hydroxymethylbilane synthase activity
INP99_RS02130	COG2959	enzyme of heme biosynthesis
INP99_RS02135	COG3071	HemY protein
INP99_RS02140	COG0765	amino acid transport
INP99_RS02145	COG0765	amino acid transport
INP99_RS02150	COG1126	abc transporter atp-binding protein
INP99_RS02155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP99_RS02160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INP99_RS02200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INP99_RS02210	COG2168	tRNA wobble position uridine thiolation
INP99_RS02215	COG2923	Belongs to the DsrF TusC family
INP99_RS02220	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
INP99_RS02225	COG2964	Protein conserved in bacteria
INP99_RS02230	COG0545	Peptidyl-prolyl cis-trans isomerase
INP99_RS02240	COG3842	ATPase activity
INP99_RS02250	COG1176	ABC-type spermidine putrescine transport system, permease component I
INP99_RS02260	COG0471	metal ion transport
INP99_RS02265	COG2814	Major facilitator Superfamily
INP99_RS02270	COG2186	Transcriptional regulator
INP99_RS02275	COG0673	inositol 2-dehydrogenase activity
INP99_RS02280	COG0673	inositol 2-dehydrogenase activity
INP99_RS02290	COG0259	pyridoxamine-phosphate oxidase activity
INP99_RS02295	COG0747	negative chemotaxis
INP99_RS02315	COG2814	Major facilitator Superfamily
INP99_RS02320	COG1763	Mo-molybdopterin cofactor biosynthetic process
INP99_RS02325	COG3026	antisigma factor binding
INP99_RS02330	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
INP99_RS02335	COG1595	DNA-templated transcription, initiation
INP99_RS02345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP99_RS02345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP99_RS02345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
INP99_RS02350	COG1105	Belongs to the carbohydrate kinase PfkB family
INP99_RS02355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP99_RS02355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP99_RS02365	COG1253	flavin adenine dinucleotide binding
INP99_RS02375	COG0084	hydrolase, TatD family'
INP99_RS02380	COG0470	DNA polymerase III
INP99_RS02385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INP99_RS02390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INP99_RS02395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INP99_RS02405	COG0587	DNA-directed DNA polymerase activity
INP99_RS02420	COG2195	Cleaves the N-terminal amino acid of tripeptides
INP99_RS02430	COG0746	molybdenum cofactor guanylyltransferase activity
INP99_RS02435	COG3084	Protein conserved in bacteria
INP99_RS02440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INP99_RS02445	COG3085	chromosome segregation
INP99_RS02460	COG3086	response to oxidative stress
INP99_RS02465	COG1473	amidohydrolase
INP99_RS02470	COG3069	C4-dicarboxylate transmembrane transporter activity
INP99_RS02480	COG3086	response to oxidative stress
INP99_RS02485	COG0531	amino acid
INP99_RS02490	COG1982	Orn Lys Arg decarboxylase major
INP99_RS02500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INP99_RS02505	COG0737	Belongs to the 5'-nucleotidase family
INP99_RS02515	COG0733	neurotransmitter:sodium symporter activity
INP99_RS02530	COG0028	Belongs to the TPP enzyme family
INP99_RS02545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INP99_RS02555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INP99_RS02560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INP99_RS02565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INP99_RS02590	COG3312	ion transport
INP99_RS02600	COG1733	regulation of RNA biosynthetic process
INP99_RS02605	COG0702	epimerase
INP99_RS02610	COG0445	tRNA wobble uridine modification
INP99_RS02615	COG0716	FMN binding
INP99_RS02620	COG3074	FtsZ-dependent cytokinesis
INP99_RS02625	COG1494	fructose-1,6-bisphosphatase
INP99_RS02635	COG1285	pathogenesis
INP99_RS02640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INP99_RS02645	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
INP99_RS02650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INP99_RS02660	COG2267	carboxylic ester hydrolase activity
INP99_RS02665	COG0471	metal ion transport
INP99_RS02685	COG3033	Beta-eliminating lyase
INP99_RS02690	COG0814	amino acid
INP99_RS02705	COG2964	Protein conserved in bacteria
INP99_RS02710	COG2831	hemolysin activation secretion protein
INP99_RS02715	COG3210	domain, Protein
INP99_RS02725	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INP99_RS02735	COG1238	metal cluster binding
INP99_RS02740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INP99_RS02750	COG0248	Ppx GppA phosphatase
INP99_RS02755	COG2911	Protein conserved in bacteria
INP99_RS02760	COG0729	surface antigen
INP99_RS02765	COG1490	D-aminoacyl-tRNA deacylase activity
INP99_RS02780	COG2258	MOSC domain
INP99_RS02785	COG0433	COG0433 Predicted ATPase
INP99_RS02790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
INP99_RS02795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INP99_RS02805	COG1045	serine acetyltransferase
INP99_RS02810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INP99_RS02815	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
INP99_RS02820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INP99_RS02825	COG0252	asparaginase activity
INP99_RS02830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INP99_RS02840	COG1288	antiporter activity
INP99_RS02845	COG2990	Protein conserved in bacteria
INP99_RS02850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INP99_RS02855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INP99_RS02865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INP99_RS02870	COG1773	rubredoxin
INP99_RS02875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
INP99_RS02880	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
INP99_RS02885	COG5557	Pfam Polysulphide reductase, NrfD
INP99_RS02890	COG0437	4 iron, 4 sulfur cluster binding
INP99_RS02895	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
INP99_RS02900	COG1704	LemA family
INP99_RS02910	COG0187	DNA topoisomerase II activity
INP99_RS02915	COG4988	ABC transporter
INP99_RS02920	COG1132	(ABC) transporter
INP99_RS02955	COG0561	phosphatase activity
INP99_RS02975	COG4667	esterase of the alpha-beta hydrolase superfamily
INP99_RS02980	COG3070	regulator of competence-specific genes
INP99_RS03015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INP99_RS03020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INP99_RS03020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INP99_RS03025	COG0463	Glycosyl transferase, family 2
INP99_RS03030	COG0569	domain protein
INP99_RS03035	COG1970	mechanosensitive ion channel activity
INP99_RS03055	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
INP99_RS03060	COG1309	transcriptional regulator
INP99_RS03065	COG0583	DNA-binding transcription factor activity
INP99_RS03070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
INP99_RS03070	COG0678	peroxiredoxin activity
INP99_RS03080	COG0705	Rhomboid family
INP99_RS03085	COG1349	DNA-binding transcription factor activity
INP99_RS03090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INP99_RS03095	COG0742	ribosomal rna small subunit methyltransferase
INP99_RS03100	COG0552	protein localization to endoplasmic reticulum
INP99_RS03105	COG2884	Cell division ATP-binding protein ftsE
INP99_RS03110	COG2177	Part of the ABC transporter FtsEX involved in
INP99_RS03115	COG0051	transcription antitermination factor activity, RNA binding
INP99_RS03120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INP99_RS03140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INP99_RS03155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INP99_RS03200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INP99_RS03220	COG0201	protein transport
INP99_RS03255	COG0564	pseudouridine synthase activity
INP99_RS03265	COG3201	nicotinamide mononucleotide transporter
INP99_RS03275	COG0513	Belongs to the DEAD box helicase family
INP99_RS03290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INP99_RS03345	COG0363	glucosamine-6-phosphate deaminase activity
INP99_RS03350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INP99_RS03355	COG1218	3'(2'),5'-bisphosphate nucleotidase
INP99_RS03360	COG1297	OPT oligopeptide transporter protein
INP99_RS03365	COG0494	nUDIX hydrolase
INP99_RS03370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INP99_RS03385	COG3700	Belongs to the class B bacterial acid phosphatase family
INP99_RS03400	COG1047	Peptidyl-prolyl cis-trans
INP99_RS03410	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
INP99_RS03415	COG0585	pseudouridine synthase activity
INP99_RS03425	COG1238	metal cluster binding
INP99_RS03435	COG4942	peptidase
INP99_RS03435	COG1388	LysM domain
INP99_RS03440	COG0442	prolyl-tRNA aminoacylation
INP99_RS03445	COG4783	chaperone-mediated protein folding
INP99_RS03450	COG3266	domain, Protein
INP99_RS03455	COG0500	methyltransferase
INP99_RS03465	COG3059	membrane
INP99_RS03480	COG0584	glycerophosphoryl diester phosphodiesterase
INP99_RS03490	COG2271	Major facilitator Superfamily
INP99_RS03495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INP99_RS03505	COG0247	lactate metabolic process
INP99_RS03520	COG1522	sequence-specific DNA binding
INP99_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INP99_RS03530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
INP99_RS03540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INP99_RS03550	COG0180	Tryptophanyl-tRNA synthetase
INP99_RS03555	COG3691	Protein conserved in bacteria
INP99_RS03560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP99_RS03565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
INP99_RS03575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INP99_RS03580	COG2183	response to ionizing radiation
INP99_RS03595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INP99_RS03600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INP99_RS03605	COG1126	abc transporter atp-binding protein
INP99_RS03610	COG0765	amino acid transport
INP99_RS03615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP99_RS03620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INP99_RS03650	COG0814	amino acid
INP99_RS03655	COG1435	thymidine kinase activity
INP99_RS03665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INP99_RS03675	COG0358	DNA primase activity
INP99_RS03680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INP99_RS03690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
INP99_RS03695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INP99_RS03700	COG4972	Pilus assembly protein
INP99_RS03720	COG4796	Type ii and iii secretion system protein
INP99_RS03725	COG1040	competence protein
INP99_RS03735	COG0606	chelatase, subunit chli
INP99_RS03745	COG2990	Protein conserved in bacteria
INP99_RS03750	COG4608	Belongs to the ABC transporter superfamily
INP99_RS03755	COG0444	Belongs to the ABC transporter superfamily
INP99_RS03760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INP99_RS03765	COG0601	transmembrane transport
INP99_RS03770	COG4166	transmembrane transport
INP99_RS03775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INP99_RS03780	COG2853	Lipoprotein
INP99_RS03785	COG0251	oxidation-reduction process
INP99_RS03810	COG1464	Belongs to the NlpA lipoprotein family
INP99_RS03825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INP99_RS03860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INP99_RS03865	COG0019	diaminopimelate decarboxylase activity
INP99_RS03880	COG0514	ATP-dependent DNA helicase (RecQ)
INP99_RS03885	COG1328	CTP reductase activity
INP99_RS03890	COG2364	Membrane
INP99_RS03895	COG0859	PFAM glycosyl transferase family 9
INP99_RS03900	COG3307	-O-antigen
INP99_RS03905	COG0191	fructose-bisphosphate aldolase activity
INP99_RS03910	COG0126	phosphoglycerate kinase activity
INP99_RS03915	COG3719	Belongs to the RNase T2 family
INP99_RS03920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP99_RS03930	COG2814	Major facilitator Superfamily
INP99_RS03935	COG3850	Histidine kinase
INP99_RS03940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INP99_RS03950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INP99_RS03960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INP99_RS03965	COG1230	cation diffusion facilitator family transporter
INP99_RS03980	COG1116	anion transmembrane transporter activity
INP99_RS03995	COG2315	Protein conserved in bacteria
INP99_RS04000	COG5295	Hep Hag repeat protein
INP99_RS04000	COG5295	Hep Hag repeat protein
INP99_RS04000	COG5295	Hep Hag repeat protein
INP99_RS04020	COG0204	Acyl-transferase
INP99_RS04030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INP99_RS04035	COG1349	DNA-binding transcription factor activity
INP99_RS04040	COG0776	regulation of translation
INP99_RS04045	COG3068	Protein conserved in bacteria
INP99_RS04050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INP99_RS04070	COG0814	amino acid
INP99_RS04075	COG1561	YicC-like family, N-terminal region
INP99_RS04080	COG0354	folic acid binding
INP99_RS04090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INP99_RS04095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INP99_RS04105	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INP99_RS04110	COG1441	menaquinone biosynthetic process
INP99_RS04120	COG0511	ligase activity, forming carbon-carbon bonds
INP99_RS04125	COG0439	Biotin carboxylase
INP99_RS04135	COG3924	membrane
INP99_RS04140	COG4145	pantothenate transmembrane transporter activity
INP99_RS04145	COG0697	spore germination
INP99_RS04155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INP99_RS04160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
INP99_RS04165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INP99_RS04170	COG0848	biopolymer transport protein
INP99_RS04175	COG0811	peptide transport
INP99_RS04180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INP99_RS04200	COG3036	rescue of stalled ribosome
INP99_RS04205	COG1393	Belongs to the ArsC family
INP99_RS04215	COG1720	tRNA m6t6A37 methyltransferase activity
INP99_RS04220	COG1575	Belongs to the MenA family. Type 1 subfamily
INP99_RS04230	COG0471	metal ion transport
INP99_RS04235	COG2814	Major facilitator Superfamily
INP99_RS04240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
INP99_RS04255	COG1194	a g-specific adenine glycosylase
INP99_RS04280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INP99_RS04285	COG0121	glutamine amidotransferase
INP99_RS04305	COG3338	carbonate dehydratase activity
INP99_RS04310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INP99_RS04315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
INP99_RS04320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INP99_RS04325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INP99_RS04330	COG0659	secondary active sulfate transmembrane transporter activity
INP99_RS04355	COG1252	NADH dehydrogenase
INP99_RS04365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
INP99_RS04370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INP99_RS04410	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
INP99_RS04415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INP99_RS04420	COG1053	succinate dehydrogenase
INP99_RS04430	COG0814	amino acid
INP99_RS04435	COG1760	l-serine dehydratase
INP99_RS04440	COG1408	metallophosphoesterase
INP99_RS04445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
INP99_RS04455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INP99_RS04460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INP99_RS04490	COG1410	methionine synthase
INP99_RS04490	COG0646	methionine synthase
INP99_RS04505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INP99_RS04520	COG0758	DNA mediated transformation
INP99_RS04525	COG3022	response to hydroperoxide
INP99_RS04540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INP99_RS04555	COG0545	Peptidyl-prolyl cis-trans isomerase
INP99_RS04560	COG0688	phosphatidylethanolamine metabolic process
INP99_RS04565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INP99_RS04570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INP99_RS04575	COG0754	glutathionylspermidine amidase activity
INP99_RS04580	COG3005	denitrification pathway
INP99_RS04585	COG3043	anaerobic respiration
INP99_RS04590	COG0348	domain, Protein
INP99_RS04595	COG0437	4 iron, 4 sulfur cluster binding
INP99_RS04600	COG0243	molybdopterin cofactor binding
INP99_RS04605	COG3062	negative regulation of establishment of protein localization
INP99_RS04610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP99_RS04615	COG3171	Protein conserved in bacteria
INP99_RS04625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INP99_RS04630	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
INP99_RS04635	COG1309	transcriptional regulator
INP99_RS04640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INP99_RS04645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INP99_RS04655	COG0814	amino acid
INP99_RS04660	COG2226	methyltransferase
INP99_RS04675	COG2194	sulfuric ester hydrolase activity
INP99_RS04680	COG0528	UMP kinase activity
INP99_RS04700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INP99_RS04705	COG0575	Belongs to the CDS family
INP99_RS04710	COG0750	zinc metalloprotease
INP99_RS04720	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
INP99_RS04730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INP99_RS04750	COG0490	domain, Protein
INP99_RS04750	COG0471	metal ion transport
INP99_RS04765	COG1027	Aspartate ammonia-lyase
INP99_RS04775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
INP99_RS04780	COG0830	nickel cation binding
INP99_RS04795	COG0804	urea catabolic process
INP99_RS04805	COG0831	urea catabolic process
INP99_RS04825	COG0006	proline dipeptidase activity
INP99_RS04830	COG0589	response to stress
INP99_RS04845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
INP99_RS04850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INP99_RS04860	COG0789	Transcriptional regulator
INP99_RS04865	COG2608	mercury ion transmembrane transporter activity
INP99_RS04870	COG2217	Heavy metal translocating P-type atpase
INP99_RS04875	COG2205	protein histidine kinase activity
INP99_RS04880	COG0745	RESPONSE REGULATOR receiver
INP99_RS04885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INP99_RS04900	COG3083	sulfuric ester hydrolase activity
INP99_RS04905	COG0402	S-adenosylhomocysteine deaminase activity
INP99_RS04930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INP99_RS04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INP99_RS04950	COG0741	lytic transglycosylase activity
INP99_RS04955	COG2350	Protein conserved in bacteria
INP99_RS04960	COG1607	acyl-coa hydrolase
INP99_RS04975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INP99_RS04985	COG3691	Protein conserved in bacteria
INP99_RS04995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INP99_RS05005	COG0037	tRNA processing
INP99_RS05010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
INP99_RS05020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INP99_RS05025	COG1121	(ABC) transporter
INP99_RS05030	COG0739	heme binding
INP99_RS05035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INP99_RS05040	COG4605	iron ion homeostasis
INP99_RS05045	COG4604	ABC transporter, ATP-binding protein
INP99_RS05050	COG4607	ABC-type enterochelin transport system periplasmic component
INP99_RS05055	COG3283	Transcriptional regulator of aromatic amino acids metabolism
INP99_RS05060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INP99_RS05070	COG0564	pseudouridine synthase activity
INP99_RS05075	COG1530	ribonuclease E activity
INP99_RS05090	COG2056	Na+-H+ antiporter family
INP99_RS05100	COG0346	lactoylglutathione lyase activity
INP99_RS05115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INP99_RS05130	COG0494	nUDIX hydrolase
INP99_RS05140	COG0641	radical SAM
INP99_RS05165	COG1271	oxidase subunit
INP99_RS05170	COG1294	oxidase, subunit
INP99_RS05180	COG0824	Thioesterase
INP99_RS05185	COG0811	peptide transport
INP99_RS05190	COG0848	biopolymer transport protein
INP99_RS05195	COG3064	Membrane
INP99_RS05205	COG2885	chlorophyll binding
INP99_RS05225	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
INP99_RS05230	COG1959	2 iron, 2 sulfur cluster binding
INP99_RS05240	COG0822	iron-sulfur transferase activity
INP99_RS05255	COG0316	Belongs to the HesB IscA family
INP99_RS05260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
INP99_RS05270	COG0443	Heat shock 70 kDa protein
INP99_RS05275	COG0633	Ferredoxin
INP99_RS05280	COG2975	iron-sulfur cluster assembly
INP99_RS05290	COG4211	Belongs to the binding-protein-dependent transport system permease family
INP99_RS05295	COG1129	ABC transporter
INP99_RS05300	COG1879	ABC-type sugar transport system periplasmic component
INP99_RS05305	COG1609	Transcriptional regulator
INP99_RS05310	COG1085	galactose-1-phosphate uridylyltransferase
INP99_RS05315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INP99_RS05320	COG2017	converts alpha-aldose to the beta-anomer
INP99_RS05325	COG2831	hemolysin activation secretion protein
INP99_RS05345	COG4535	Mg2 and Co2 transporter CorC
INP99_RS05350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
INP99_RS05355	COG1127	ABC transporter
INP99_RS05360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INP99_RS05365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
INP99_RS05370	COG2854	intermembrane phospholipid transfer
INP99_RS05375	COG3113	response to antibiotic
INP99_RS05380	COG5007	Belongs to the BolA IbaG family
INP99_RS05390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INP99_RS05395	COG0460	homoserine dehydrogenase
INP99_RS05395	COG0527	aspartate kinase activity
INP99_RS05405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INP99_RS05410	COG1263	PTS System
INP99_RS05410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP99_RS05410	COG2190	(PTS) system
INP99_RS05415	COG2091	lysine biosynthetic process via aminoadipic acid
INP99_RS05420	COG0330	HflC and HflK could
INP99_RS05425	COG0330	HflC and HflK could
INP99_RS05430	COG1858	cytochrome C peroxidase
INP99_RS05435	COG0477	Major facilitator Superfamily
INP99_RS05440	COG0352	thiamine-phosphate diphosphorylase activity
INP99_RS05445	COG0351	phosphomethylpyrimidine kinase
INP99_RS05455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
INP99_RS05460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INP99_RS05465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INP99_RS05470	COG1116	anion transmembrane transporter activity
INP99_RS05490	COG0626	cystathionine gamma-synthase activity
INP99_RS05495	COG3118	belongs to the thioredoxin family
INP99_RS05500	COG1793	dna ligase
INP99_RS05510	COG1126	abc transporter atp-binding protein
INP99_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP99_RS05520	COG4215	(ABC) transporter
INP99_RS05525	COG4160	amino acid transport
INP99_RS05535	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
INP99_RS05540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INP99_RS05550	COG1674	ftsk spoiiie
INP99_RS05555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INP99_RS05580	COG1966	Carbon starvation protein
INP99_RS05590	COG0275	rRNA processing
INP99_RS05595	COG3116	cell division
INP99_RS05600	COG0768	penicillin binding
INP99_RS05610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INP99_RS05625	COG0772	Belongs to the SEDS family
INP99_RS05630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INP99_RS05645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
INP99_RS05650	COG0849	cell division
INP99_RS05655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INP99_RS05660	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INP99_RS05665	COG0737	Belongs to the 5'-nucleotidase family
INP99_RS05670	COG1605	Chorismate mutase
INP99_RS05670	COG0077	Prephenate dehydratase
INP99_RS05675	COG2824	Alkylphosphonate utilization operon protein PhnA
INP99_RS05680	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
INP99_RS05690	COG1595	DNA-templated transcription, initiation
INP99_RS05705	COG3219	Protein conserved in bacteria
INP99_RS05710	COG3220	belongs to the UPF0276 family
INP99_RS05720	COG2259	Doxx family
INP99_RS05735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INP99_RS05740	COG0084	hydrolase, TatD family'
INP99_RS05745	COG0602	queuosine metabolic process
INP99_RS05755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
INP99_RS05760	COG4988	ABC transporter
INP99_RS05765	COG0492	ferredoxin-NADP+ reductase activity
INP99_RS05770	COG3118	belongs to the thioredoxin family
INP99_RS05780	COG0471	metal ion transport
INP99_RS05785	COG1573	uracil-dna glycosylase
INP99_RS05790	COG1328	CTP reductase activity
INP99_RS05790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INP99_RS05795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INP99_RS05805	COG0497	DNA recombination
INP99_RS05815	COG3091	SprT-like family
INP99_RS05820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INP99_RS05825	COG1393	Belongs to the ArsC family
INP99_RS05845	COG1876	peptidase activity
INP99_RS05855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP99_RS05860	COG1137	ATPase activity
INP99_RS05865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
INP99_RS05870	COG3117	lipopolysaccharide transmembrane transporter activity
INP99_RS05880	COG0312	modulator of DNA gyrase
INP99_RS05885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INP99_RS05890	COG1160	GTP binding
INP99_RS05905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
INP99_RS05915	COG1946	Acyl-CoA thioesterase
INP99_RS05920	COG0012	GTP binding
INP99_RS05925	COG0193	aminoacyl-tRNA hydrolase activity
INP99_RS05940	COG2850	peptidyl-arginine hydroxylation
INP99_RS05950	COG0494	nUDIX hydrolase
INP99_RS05955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INP99_RS05980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INP99_RS05985	COG0450	alkyl hydroperoxide reductase
INP99_RS05990	COG0626	cystathionine gamma-synthase activity
INP99_RS05995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INP99_RS06000	COG5413	integral membrane protein
INP99_RS06010	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
INP99_RS06015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INP99_RS06020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
INP99_RS06030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INP99_RS06030	COG0475	glutathione-regulated potassium exporter activity
INP99_RS06040	COG2363	Small membrane protein
INP99_RS06045	COG1643	Atp-dependent helicase
INP99_RS06060	COG3069	C4-dicarboxylate transmembrane transporter activity
INP99_RS06065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INP99_RS06070	COG0617	tRNA 3'-terminal CCA addition
INP99_RS06075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
INP99_RS06080	COG0658	competence protein
INP99_RS06080	COG2333	competence protein COMEC
INP99_RS06090	COG1663	tetraacyldisaccharide 4'-kinase activity
INP99_RS06095	COG2835	tetraacyldisaccharide 4'-kinase activity
INP99_RS06115	COG0861	Integral membrane protein TerC family
INP99_RS06120	COG3842	ATPase activity
INP99_RS06125	COG1178	ABC-type Fe3 transport system permease component
INP99_RS06130	COG1840	ABC-type Fe3 transport system, periplasmic component
INP99_RS06135	COG1181	Belongs to the D-alanine--D-alanine ligase family
INP99_RS06135	COG2918	glutathione biosynthetic process
INP99_RS06140	COG1702	phosphate starvation-inducible protein PhoH
INP99_RS06150	COG0561	phosphatase activity
INP99_RS06160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INP99_RS06165	COG2926	Belongs to the UPF0265 family
INP99_RS06185	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
INP99_RS06190	COG0456	acetyltransferase
INP99_RS06200	COG2864	formate dehydrogenase
INP99_RS06205	COG0437	4 iron, 4 sulfur cluster binding
INP99_RS06220	COG1840	ABC-type Fe3 transport system, periplasmic component
INP99_RS06225	COG0210	DNA helicase
INP99_RS06230	COG0601	transmembrane transport
INP99_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INP99_RS06240	COG0444	Belongs to the ABC transporter superfamily
INP99_RS06245	COG4608	Belongs to the ABC transporter superfamily
INP99_RS06250	COG2814	Major facilitator Superfamily
INP99_RS06270	COG1840	ABC-type Fe3 transport system, periplasmic component
INP99_RS06275	COG1840	ABC-type Fe3 transport system, periplasmic component
INP99_RS06295	COG0583	DNA-binding transcription factor activity
INP99_RS06300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
INP99_RS06305	COG1687	branched-chain amino acid
INP99_RS06325	COG0517	IMP dehydrogenase activity
INP99_RS06325	COG0516	GMP reductase activity
INP99_RS06330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
INP99_RS06330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
INP99_RS06365	COG2198	Histidine kinase
INP99_RS06365	COG0784	Response regulator, receiver
INP99_RS06365	COG5002	protein histidine kinase activity
INP99_RS06365	COG2198	Histidine kinase
INP99_RS06365	COG0784	Response regulator, receiver
INP99_RS06365	COG5002	protein histidine kinase activity
INP99_RS06370	COG1444	tRNA N-acetyltransferase activity
INP99_RS06380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INP99_RS06385	COG1090	epimerase
INP99_RS06390	COG1438	arginine binding
INP99_RS06395	COG0039	L-malate dehydrogenase activity
INP99_RS06400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INP99_RS06420	COG4991	sh3 domain protein
INP99_RS06425	COG0306	phosphate transporter
INP99_RS06430	COG1392	Phosphate transport regulator
INP99_RS06435	COG3025	triphosphatase activity
INP99_RS06440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INP99_RS06445	COG1522	sequence-specific DNA binding
INP99_RS06455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
INP99_RS06460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INP99_RS06465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
INP99_RS06470	COG1177	transmembrane transport
INP99_RS06475	COG1176	ABC-type spermidine putrescine transport system, permease component I
INP99_RS06480	COG3842	ATPase activity
INP99_RS06490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INP99_RS06495	COG3108	Peptidase M15
INP99_RS06500	COG2989	Protein conserved in bacteria
INP99_RS06505	COG0793	Belongs to the peptidase S41A family
INP99_RS06510	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
INP99_RS06515	COG2995	paraquat-inducible protein a
INP99_RS06520	COG3008	intermembrane lipid transfer
INP99_RS06525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
INP99_RS06530	COG0517	IMP dehydrogenase activity
INP99_RS06530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
INP99_RS06540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INP99_RS06555	COG2249	NAD(P)H dehydrogenase (quinone) activity
INP99_RS06580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INP99_RS06600	COG2207	Transcriptional regulator
INP99_RS06615	COG3101	peptidyl-lysine hydroxylation
INP99_RS06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INP99_RS06625	COG2890	protein-(glutamine-N5) methyltransferase activity
INP99_RS06630	COG2912	Transglutaminase-like superfamily
INP99_RS06640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INP99_RS06645	COG4591	ABC-type transport system involved in lipoprotein release permease component
INP99_RS06650	COG1136	(ABC) transporter
INP99_RS06655	COG4591	ABC-type transport system involved in lipoprotein release permease component
INP99_RS06660	COG3105	Protein conserved in bacteria
INP99_RS06665	COG0251	oxidation-reduction process
INP99_RS06675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
INP99_RS06680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
INP99_RS06680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INP99_RS06685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INP99_RS06690	COG0028	Belongs to the TPP enzyme family
INP99_RS06695	COG0440	acetolactate synthase activity
INP99_RS06705	COG3842	ATPase activity
INP99_RS06710	COG1178	ABC-type Fe3 transport system permease component
INP99_RS06715	COG3842	ATPase activity
INP99_RS06735	COG0527	aspartate kinase activity
INP99_RS06740	COG2949	membrane
INP99_RS06750	COG0778	Nitroreductase
INP99_RS06755	COG0616	signal peptide processing
INP99_RS06765	COG4172	Belongs to the ABC transporter superfamily
INP99_RS06770	COG4172	Belongs to the ABC transporter superfamily
INP99_RS06775	COG4171	peptide transport system, permease
INP99_RS06780	COG4168	peptide transport system, permease
INP99_RS06785	COG4166	transmembrane transport
INP99_RS06790	COG3106	COG3106 Predicted ATPase
INP99_RS06800	COG2608	mercury ion transmembrane transporter activity
INP99_RS06810	COG1305	Transglutaminase-like
INP99_RS06830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INP99_RS06835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INP99_RS06840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INP99_RS06845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INP99_RS06850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INP99_RS06855	COG0539	negative regulation of cytoplasmic translation
INP99_RS06865	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
INP99_RS06870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
INP99_RS06880	COG0023	Translation Initiation Factor
INP99_RS06885	COG3094	Invasion gene expression up-regulator, SirB
INP99_RS06890	COG0488	(ABC) transporter
INP99_RS06895	COG3683	transport system, periplasmic component
INP99_RS06900	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
INP99_RS06905	COG0778	Nitroreductase
INP99_RS06910	COG1434	Gram-negative-bacterium-type cell wall biogenesis
INP99_RS06930	COG0469	pyruvate kinase activity
INP99_RS06935	COG0305	Participates in initiation and elongation during chromosome replication
INP99_RS06940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INP99_RS06965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INP99_RS06990	COG0670	Belongs to the BI1 family
INP99_RS06995	COG1555	photosystem II stabilization
INP99_RS07000	COG0567	Dehydrogenase, E1 component
INP99_RS07005	COG0508	dehydrogenase complex catalyzes the overall conversion of
INP99_RS07020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
INP99_RS07025	COG0009	L-threonylcarbamoyladenylate synthase
INP99_RS07030	COG1187	pseudouridine synthase activity
INP99_RS07035	COG0583	DNA-binding transcription factor activity
INP99_RS07045	COG2890	protein-(glutamine-N5) methyltransferase activity
INP99_RS07050	COG2840	Smr protein MutS2
INP99_RS07060	COG3102	Protein conserved in bacteria
INP99_RS07070	COG3133	Outer membrane lipoprotein
INP99_RS07090	COG0489	protein tyrosine kinase activity
INP99_RS07100	COG1538	Outer membrane efflux protein
INP99_RS07105	COG0577	efflux transmembrane transporter activity
INP99_RS07105	COG1136	(ABC) transporter
INP99_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INP99_RS07125	COG1640	4-alpha-glucanotransferase
INP99_RS07130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INP99_RS07135	COG1523	belongs to the glycosyl hydrolase 13 family
INP99_RS07150	COG0058	SHG alpha-glucan phosphorylase activity
INP99_RS07155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INP99_RS07165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INP99_RS07170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
INP99_RS07175	COG1280	lysine exporter protein (LysE YggA)
INP99_RS07185	COG0633	Ferredoxin
INP99_RS07195	COG3111	PFAM Bacterial OB fold (BOF) protein
INP99_RS07200	COG0745	RESPONSE REGULATOR receiver
INP99_RS07205	COG0642	Histidine kinase
INP99_RS07225	COG0195	Participates in both transcription termination and antitermination
INP99_RS07230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INP99_RS07240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INP99_RS07250	COG0287	Prephenate dehydrogenase
INP99_RS07250	COG1605	Chorismate mutase
INP99_RS07255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INP99_RS07255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INP99_RS07260	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
INP99_RS07265	COG2166	iron-sulfur cluster assembly
INP99_RS07270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INP99_RS07275	COG1525	nuclease
INP99_RS07285	COG1346	cytolysis
INP99_RS07295	COG0488	(ABC) transporter
INP99_RS07305	COG0733	neurotransmitter:sodium symporter activity
INP99_RS07310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INP99_RS07330	COG4656	Part of a membrane complex involved in electron transport
INP99_RS07340	COG4657	Part of a membrane complex involved in electron transport
INP99_RS07345	COG1289	transmembrane transporter activity
INP99_RS07360	COG3098	single-species biofilm formation
INP99_RS07365	COG0564	pseudouridine synthase activity
INP99_RS07370	COG3140	Belongs to the UPF0181 family
INP99_RS07375	COG1278	Cold shock
INP99_RS07385	COG1067	ATP-dependent peptidase activity
INP99_RS07390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INP99_RS07395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INP99_RS07400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INP99_RS07405	COG2252	PERMEase
INP99_RS07410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
INP99_RS07415	COG1074	ATP-dependent DNA helicase activity
INP99_RS07420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INP99_RS07425	COG2999	glutathione oxidoreductase activity
INP99_RS07430	COG2966	Psort location CytoplasmicMembrane, score
INP99_RS07435	COG3610	response to peptide
INP99_RS07465	COG0783	Belongs to the Dps family
INP99_RS07470	COG0747	negative chemotaxis
INP99_RS07475	COG0601	transmembrane transport
INP99_RS07480	COG0444	Belongs to the ABC transporter superfamily
INP99_RS07485	COG4608	Belongs to the ABC transporter superfamily
INP99_RS07505	COG3585	molybdate ion transport
INP99_RS07540	COG1136	(ABC) transporter
INP99_RS07550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INP99_RS07575	COG2920	part of a sulfur-relay system
INP99_RS07590	COG1528	Iron-storage protein
INP99_RS07595	COG1528	Iron-storage protein
INP99_RS07600	COG2925	Exonuclease
INP99_RS07605	COG0697	spore germination
INP99_RS07615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
INP99_RS07620	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
INP99_RS07630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INP99_RS07635	COG0589	response to stress
INP99_RS07640	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
INP99_RS07650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INP99_RS07655	COG0583	DNA-binding transcription factor activity
INP99_RS07660	COG0613	PHP domain protein
INP99_RS07665	COG0167	dihydroorotate dehydrogenase activity
INP99_RS07670	COG0308	aminopeptidase N
INP99_RS07675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INP99_RS07680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
INP99_RS07685	COG1448	Aminotransferase
INP99_RS07695	COG0314	molybdopterin synthase activity
INP99_RS07700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
INP99_RS07705	COG0315	cyclic pyranopterin monophosphate synthase activity
INP99_RS07710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INP99_RS07730	COG0142	geranyltranstransferase activity
INP99_RS07735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INP99_RS07740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INP99_RS07745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INP99_RS07755	COG0676	glucose-6-phosphate 1-epimerase activity
INP99_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INP99_RS07785	COG0512	Glutamine amidotransferase of anthranilate synthase
INP99_RS07790	COG1942	4-Oxalocrotonate Tautomerase
INP99_RS07800	COG0135	phosphoribosylanthranilate isomerase activity
INP99_RS07800	COG0134	indole-3-glycerol-phosphate synthase activity
INP99_RS07805	COG4221	oxidoreductase activity
INP99_RS07810	COG0133	tryptophan synthase activity
INP99_RS07820	COG2969	positive regulation of protein catabolic process
INP99_RS07825	COG0625	glutathione transferase activity
INP99_RS07840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INP99_RS07845	COG0791	NLP P60 protein
INP99_RS07850	COG0776	regulation of translation
INP99_RS07860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INP99_RS07875	COG0616	signal peptide processing
INP99_RS07880	COG0017	Asparaginyl-tRNA synthetase
INP99_RS07885	COG0288	reversible hydration of carbon dioxide
INP99_RS07890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
INP99_RS07910	COG2062	phosphohistidine phosphatase, SixA
INP99_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INP99_RS07920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INP99_RS07925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INP99_RS07935	COG1534	Rna-binding protein
INP99_RS07940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INP99_RS07945	COG2027	D-alanyl-D-alanine carboxypeptidase
INP99_RS07950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INP99_RS07955	COG1286	toxin biosynthetic process
INP99_RS07960	COG3092	negative regulation of chromosome organization
INP99_RS07970	COG0280	phosphate acetyltransferase
INP99_RS07970	COG0857	belongs to the CobB CobQ family
INP99_RS07995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INP99_RS08000	COG0318	PFAM AMP-dependent synthetase and ligase
INP99_RS08005	COG3065	identical protein binding
INP99_RS08010	COG1214	PFAM Peptidase M22, glycoprotease
INP99_RS08015	COG1199	ATP-dependent helicase activity
INP99_RS08060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INP99_RS08065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
INP99_RS08075	COG0024	Methionine aminopeptidase
INP99_RS08080	COG0316	Belongs to the HesB IscA family
INP99_RS08085	COG3112	Uncharacterised protein family (UPF0231)
INP99_RS08090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INP99_RS08095	COG0672	)-iron permease
INP99_RS08110	COG0577	efflux transmembrane transporter activity
INP99_RS08120	COG0577	efflux transmembrane transporter activity
INP99_RS08120	COG1136	(ABC) transporter
INP99_RS08155	COG4139	cobalamin transport
INP99_RS08160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INP99_RS08165	COG1858	cytochrome C peroxidase
INP99_RS08170	COG2951	lytic endotransglycosylase activity
INP99_RS08175	COG1216	Glycosyl transferase, family 2
INP99_RS08180	COG1216	Glycosyl transferase, family 2
INP99_RS08190	COG3306	glycosyltransferase involved in LPS biosynthesis
INP99_RS08215	COG3099	Belongs to the UPF0263 family
INP99_RS08220	COG0309	Hydrogenase expression formation protein (HypE)
INP99_RS08225	COG0409	Hydrogenase expression formation protein
INP99_RS08230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
INP99_RS08235	COG0375	protein maturation
INP99_RS08240	COG0789	Transcriptional regulator
INP99_RS08245	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
INP99_RS08250	COG0310	cobalt ion transport
INP99_RS08255	COG0310	cobalt ion transport
INP99_RS08260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INP99_RS08265	COG1122	ATPase activity
INP99_RS08275	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
INP99_RS08285	COG3260	NADH ubiquinone oxidoreductase 20
INP99_RS08290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INP99_RS08295	COG3261	NADH dehydrogenase
INP99_RS08295	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
INP99_RS08300	COG0651	ATP synthesis coupled electron transport
INP99_RS08305	COG4237	Hydrogenase 4 membrane
INP99_RS08310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INP99_RS08315	COG0650	Formate hydrogenlyase subunit 4
INP99_RS08320	COG0651	ATP synthesis coupled electron transport
INP99_RS08325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP99_RS08330	COG0298	carbon dioxide binding
INP99_RS08335	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
INP99_RS08340	COG2431	L-lysine efflux transmembrane transporter activity
INP99_RS08345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INP99_RS08350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INP99_RS08365	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
INP99_RS08370	COG0708	Exodeoxyribonuclease III
INP99_RS08380	COG0564	pseudouridine synthase activity
INP99_RS08390	COG1757	Na H antiporter
INP99_RS08395	COG2916	Histone family protein nucleoid-structuring protein H-NS
INP99_RS08400	COG0788	formyltetrahydrofolate deformylase activity
INP99_RS08410	COG2814	Major facilitator Superfamily
INP99_RS08420	COG0303	'Molybdopterin
INP99_RS08425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
INP99_RS08430	COG2391	methyltransferase activity
INP99_RS08435	COG0425	Belongs to the sulfur carrier protein TusA family
INP99_RS08445	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
INP99_RS08450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
INP99_RS08460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INP99_RS08465	COG3107	peptidoglycan biosynthetic process
INP99_RS08475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
INP99_RS08480	COG2823	Periplasmic or secreted lipoprotein
INP99_RS08485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INP99_RS08490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INP99_RS08500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INP99_RS08510	COG1914	H( )-stimulated, divalent metal cation uptake system
INP99_RS08515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
INP99_RS08520	COG1984	allophanate hydrolase subunit 2
INP99_RS08525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
INP99_RS08535	COG0795	lipopolysaccharide-transporting ATPase activity
INP99_RS08540	COG0795	lipopolysaccharide-transporting ATPase activity
INP99_RS08545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
INP99_RS08550	COG3021	interspecies interaction between organisms
INP99_RS08555	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
INP99_RS08560	COG1368	sulfuric ester hydrolase activity
INP99_RS08565	COG0281	malic enzyme
INP99_RS08565	COG0280	phosphate acetyltransferase
INP99_RS08570	COG3955	Domain of unknown function (DUF1919)
INP99_RS08575	COG1187	pseudouridine synthase activity
INP99_RS08580	COG2814	Major facilitator Superfamily
INP99_RS08585	COG1115	amino acid carrier protein
INP99_RS08595	COG0671	phosphoesterase, PA-phosphatase related
INP99_RS08615	COG0187	DNA topoisomerase II activity
INP99_RS08625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INP99_RS08630	COG0786	glutamate:sodium symporter activity
INP99_RS08635	COG0285	dihydrofolate synthase activity
INP99_RS08650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INP99_RS08655	COG0586	Pfam SNARE associated Golgi protein
INP99_RS08675	COG0307	riboflavin synthase, alpha
INP99_RS08680	COG0534	Mate efflux family protein
INP99_RS08685	COG1530	ribonuclease E activity
INP99_RS08690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INP99_RS08715	COG0583	DNA-binding transcription factor activity
INP99_RS08720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INP99_RS08725	COG3630	sodium ion export across plasma membrane
INP99_RS08730	COG0511	ligase activity, forming carbon-carbon bonds
INP99_RS08730	COG5016	pyruvate
INP99_RS08750	COG4166	transmembrane transport
INP99_RS08755	COG2832	Protein of unknown function (DUF454)
INP99_RS08760	COG0339	signal peptide processing
INP99_RS08770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INP99_RS08770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INP99_RS08775	COG1560	Kdo2-lipid A biosynthetic process
INP99_RS08780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INP99_RS08785	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INP99_RS08795	COG2190	(PTS) system
INP99_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP99_RS08795	COG1263	PTS System
INP99_RS08805	COG0058	SHG alpha-glucan phosphorylase activity
INP99_RS08810	COG1640	4-alpha-glucanotransferase
INP99_RS08815	COG1609	Transcriptional regulator
INP99_RS08820	COG1275	C4-dicarboxylate transporter malic acid transport protein
INP99_RS08825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INP99_RS08830	COG2841	Protein conserved in bacteria
INP99_RS08845	COG2860	membrane
INP99_RS08855	COG2354	Protein conserved in bacteria
INP99_RS08860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INP99_RS08870	COG1560	Kdo2-lipid A biosynthetic process
INP99_RS08875	COG0730	response to heat
INP99_RS08880	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
INP99_RS08885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INP99_RS08890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
INP99_RS08890	COG3264	Mechanosensitive ion channel
INP99_RS08895	COG0318	PFAM AMP-dependent synthetase and ligase
INP99_RS08900	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
INP99_RS08905	COG0596	Alpha beta hydrolase
INP99_RS08910	COG0716	FMN binding
INP99_RS08915	COG0735	belongs to the Fur family
INP99_RS08920	COG0137	argininosuccinate synthase activity
INP99_RS08925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INP99_RS08945	COG4735	regulation of single-species biofilm formation
INP99_RS09000	COG3698	Phosphodiester glycosidase
INP99_RS09005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
INP99_RS09010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INP99_RS09015	COG2226	methyltransferase
INP99_RS09025	COG1944	ATP diphosphatase activity
INP99_RS09030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INP99_RS09035	COG3381	protein complex oligomerization
INP99_RS09040	COG2249	NAD(P)H dehydrogenase (quinone) activity
INP99_RS09050	COG0330	HflC and HflK could
INP99_RS09055	COG1119	ATPase activity
INP99_RS09065	COG2932	Transcriptional regulator
INP99_RS09070	COG0791	NLP P60 protein
INP99_RS09075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INP99_RS09080	COG0508	dehydrogenase complex catalyzes the overall conversion of
INP99_RS09085	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
INP99_RS09095	COG5339	Protein conserved in bacteria
INP99_RS09100	COG0443	Heat shock 70 kDa protein
INP99_RS09115	COG0484	heat shock protein binding
INP99_RS09120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
INP99_RS09125	COG4149	molybdate abc transporter
INP99_RS09130	COG0725	ABC transporter, periplasmic molybdate-binding protein
INP99_RS09135	COG2005	Transcriptional regulator
INP99_RS09145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INP99_RS09150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INP99_RS09150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INP99_RS09160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
INP99_RS09175	COG4795	General secretion pathway protein
INP99_RS09180	COG2165	general secretion pathway protein
INP99_RS09185	COG0483	inositol monophosphate 1-phosphatase activity
INP99_RS09195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
INP99_RS09200	COG1178	ABC-type Fe3 transport system permease component
INP99_RS09205	COG4143	(ABC) transporter
INP99_RS09215	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
INP99_RS09225	COG1704	LemA family
INP99_RS09235	COG0247	lactate metabolic process
INP99_RS09235	COG0277	FAD linked oxidase domain protein
INP99_RS09240	COG2050	protein possibly involved in aromatic compounds catabolism
INP99_RS09245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INP99_RS09285	COG2927	DNA polymerase III (CHI subunit)
INP99_RS09290	COG0114	fumarate hydratase activity
INP99_RS09295	COG2268	Band 7 protein
INP99_RS09305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
INP99_RS09315	COG1482	cell wall glycoprotein biosynthetic process
INP99_RS09320	COG2190	(PTS) system
INP99_RS09325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INP99_RS09330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP99_RS09335	COG1162	GTPase activity
INP99_RS09355	COG0802	atpase or kinase
INP99_RS09360	COG0860	N-Acetylmuramoyl-L-alanine amidase
INP99_RS09360	COG1388	LysM domain
INP99_RS09375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
INP99_RS09405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INP99_RS09410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INP99_RS09415	COG1758	RNA polymerase activity
INP99_RS09425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INP99_RS09430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
INP99_RS09435	COG1022	Amp-dependent synthetase and ligase
INP99_RS09445	COG4536	flavin adenine dinucleotide binding
INP99_RS09470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INP99_RS09485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INP99_RS09485	COG0140	phosphoribosyl-ATP diphosphatase activity
INP99_RS09490	COG2801	Transposase and inactivated derivatives
INP99_RS09500	COG4137	Cytochrome C assembly protein
INP99_RS09505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INP99_RS09520	COG2233	PERMEase
INP99_RS09525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INP99_RS09540	COG0346	lactoylglutathione lyase activity
INP99_RS09555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INP99_RS09560	COG1138	Cytochrome C-type biogenesis protein
INP99_RS09565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
INP99_RS09570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INP99_RS09575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INP99_RS09580	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INP99_RS09585	COG4133	protoheme IX ABC transporter activity
INP99_RS09590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
INP99_RS09595	COG2020	methyltransferase activity
INP99_RS09600	COG2976	Protein conserved in bacteria
INP99_RS09610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INP99_RS09615	COG1426	Protein conserved in bacteria
INP99_RS09620	COG3063	Type IV pilus biogenesis stability protein PilW
INP99_RS09635	COG1686	Belongs to the peptidase S11 family
INP99_RS09645	COG1121	(ABC) transporter
INP99_RS09650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INP99_RS09655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INP99_RS09665	COG1472	Belongs to the glycosyl hydrolase 3 family
INP99_RS09670	COG5633	Lipoprotein
INP99_RS09675	COG0537	adenosine 5'-monophosphoramidase activity
INP99_RS09680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INP99_RS09685	COG1971	Probably functions as a manganese efflux pump
INP99_RS09705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INP99_RS09710	COG0594	ribonuclease P activity