locus-tag	class	description
PARA_RS00005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PARA_RS00010	COG1022	Amp-dependent synthetase and ligase
PARA_RS00020	COG4536	flavin adenine dinucleotide binding
PARA_RS00025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PARA_RS00025	COG0131	Imidazoleglycerol-phosphate dehydratase
PARA_RS00040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PARA_RS00050	COG0107	imidazoleglycerol-phosphate synthase activity
PARA_RS00060	COG4137	Cytochrome C assembly protein
PARA_RS00065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PARA_RS00080	COG2233	PERMEase
PARA_RS00085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PARA_RS00100	COG0346	lactoylglutathione lyase activity
PARA_RS00115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PARA_RS00120	COG1138	Cytochrome C-type biogenesis protein
PARA_RS00125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PARA_RS00130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PARA_RS00135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PARA_RS00140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PARA_RS00145	COG4133	protoheme IX ABC transporter activity
PARA_RS00150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PARA_RS00160	COG2976	Protein conserved in bacteria
PARA_RS00170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PARA_RS00175	COG1426	Protein conserved in bacteria
PARA_RS00180	COG3063	Type IV pilus biogenesis stability protein PilW
PARA_RS00190	COG1686	Belongs to the peptidase S11 family
PARA_RS00200	COG1121	(ABC) transporter
PARA_RS00205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PARA_RS00210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PARA_RS00230	COG1472	Belongs to the glycosyl hydrolase 3 family
PARA_RS00235	COG5633	Lipoprotein
PARA_RS00240	COG0537	adenosine 5'-monophosphoramidase activity
PARA_RS00245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PARA_RS00250	COG1971	Probably functions as a manganese efflux pump
PARA_RS00270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PARA_RS00275	COG0594	ribonuclease P activity
PARA_RS00285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PARA_RS00290	COG0592	DNA-directed DNA polymerase activity
PARA_RS00300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PARA_RS00305	COG0363	glucosamine-6-phosphate deaminase activity
PARA_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PARA_RS00315	COG1737	Transcriptional regulator
PARA_RS00325	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PARA_RS00330	COG2190	(PTS) system
PARA_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PARA_RS00330	COG1263	PTS System
PARA_RS00335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PARA_RS00355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PARA_RS00365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PARA_RS00380	COG1811	Na channel or pump
PARA_RS00385	COG5295	Hep Hag repeat protein
PARA_RS00400	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PARA_RS00405	COG0437	4 iron, 4 sulfur cluster binding
PARA_RS00410	COG3301	Polysulphide reductase, NrfD
PARA_RS00415	COG1138	Cytochrome C-type biogenesis protein
PARA_RS00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PARA_RS00425	COG4235	cytochrome complex assembly
PARA_RS00425	COG3088	subunit of a heme lyase
PARA_RS00430	COG2081	HI0933 family
PARA_RS00435	COG2267	carboxylic ester hydrolase activity
PARA_RS00450	COG1169	isochorismate synthase
PARA_RS00455	COG0436	Aminotransferase
PARA_RS00460	COG4589	Belongs to the CDS family
PARA_RS00470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PARA_RS00485	COG0681	Belongs to the peptidase S26 family
PARA_RS00490	COG0481	GTPase activity
PARA_RS00505	COG0590	tRNA wobble adenosine to inosine editing
PARA_RS00520	COG0730	response to heat
PARA_RS00530	COG3023	N-Acetylmuramoyl-L-alanine amidase
PARA_RS00535	COG4969	Belongs to the N-Me-Phe pilin family
PARA_RS00540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PARA_RS00545	COG1459	type II secretion system
PARA_RS00550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PARA_RS00555	COG0237	dephospho-CoA kinase activity
PARA_RS00570	COG0513	Belongs to the DEAD box helicase family
PARA_RS00575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PARA_RS00580	COG1792	Involved in formation and maintenance of cell shape
PARA_RS00585	COG1077	Cell shape determining protein MreB Mrl
PARA_RS00590	COG4178	(ABC) transporter
PARA_RS00600	COG0799	negative regulation of ribosome biogenesis
PARA_RS00610	COG0768	penicillin binding
PARA_RS00615	COG0772	Belongs to the SEDS family
PARA_RS00620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PARA_RS00620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PARA_RS00625	COG1686	Belongs to the peptidase S11 family
PARA_RS00655	COG2814	Major facilitator Superfamily
PARA_RS00660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PARA_RS00675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PARA_RS00680	COG2252	PERMEase
PARA_RS00685	COG0826	peptidase U32
PARA_RS00690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PARA_RS00695	COG0343	queuine tRNA-ribosyltransferase activity
PARA_RS00700	COG3945	hemerythrin HHE cation binding domain
PARA_RS00705	COG0425	Belongs to the sulfur carrier protein TusA family
PARA_RS00710	COG1862	Preprotein translocase
PARA_RS00715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PARA_RS00720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PARA_RS00725	COG0628	permease
PARA_RS00730	COG0347	Belongs to the P(II) protein family
PARA_RS00735	COG0521	Mo-molybdopterin cofactor biosynthetic process
PARA_RS00740	COG0542	response to heat
PARA_RS00745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PARA_RS00750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PARA_RS00755	COG0564	pseudouridine synthase activity
PARA_RS00760	COG1496	oxidoreductase activity
PARA_RS00775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PARA_RS00825	COG0151	Belongs to the GarS family
PARA_RS00830	COG0138	bifunctional purine biosynthesis protein purh
PARA_RS00835	COG2259	Doxx family
PARA_RS00840	COG4232	protein-disulfide reductase activity
PARA_RS00845	COG0745	RESPONSE REGULATOR receiver
PARA_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PARA_RS00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PARA_RS00870	COG0697	spore germination
PARA_RS00885	COG0142	geranyltranstransferase activity
PARA_RS00900	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PARA_RS00910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PARA_RS00910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PARA_RS00925	COG2391	methyltransferase activity
PARA_RS00930	COG0425	Belongs to the sulfur carrier protein TusA family
PARA_RS00935	COG2731	YhcH YjgK YiaL family protein
PARA_RS00945	COG4785	May be involved in cell division
PARA_RS00950	COG0513	Belongs to the DEAD box helicase family
PARA_RS00955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PARA_RS00970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PARA_RS00975	COG1115	amino acid carrier protein
PARA_RS00980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PARA_RS00990	COG0560	Phosphoserine phosphatase
PARA_RS01010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PARA_RS01015	COG0335	large ribosomal subunit rRNA binding
PARA_RS01035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PARA_RS01045	COG0805	protein transport
PARA_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PARA_RS01065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PARA_RS01080	COG1942	4-Oxalocrotonate Tautomerase
PARA_RS01085	COG2991	Protein conserved in bacteria
PARA_RS01090	COG1477	protein flavinylation
PARA_RS01095	COG2871	sodium ion transport
PARA_RS01100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PARA_RS01110	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PARA_RS01125	COG0271	Belongs to the BolA IbaG family
PARA_RS01130	COG3056	Lipoprotein
PARA_RS01135	COG0598	Magnesium transport protein CorA
PARA_RS01140	COG0762	integral membrane protein
PARA_RS01145	COG1872	DUF167
PARA_RS01155	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
PARA_RS01160	COG1466	dna polymerase III delta subunit
PARA_RS01165	COG1368	sulfuric ester hydrolase activity
PARA_RS01170	COG0494	nUDIX hydrolase
PARA_RS01185	COG4701	Protein of unknown function (DUF721)
PARA_RS01190	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PARA_RS01195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PARA_RS01205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PARA_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
PARA_RS01220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PARA_RS01240	COG1399	metal-binding, possibly nucleic acid-binding protein
PARA_RS01245	COG1132	(ABC) transporter
PARA_RS01250	COG4977	sequence-specific DNA binding
PARA_RS01250	COG1917	Cupin 2, conserved barrel domain protein
PARA_RS01255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PARA_RS01260	COG0859	PFAM glycosyl transferase family 9
PARA_RS01280	COG0751	glycine-tRNA ligase activity
PARA_RS01290	COG2852	Protein conserved in bacteria
PARA_RS01305	COG4545	Glutaredoxin-related protein
PARA_RS01320	COG4206	TonB-dependent receptor
PARA_RS01340	COG0105	UTP biosynthetic process
PARA_RS01350	COG1088	dTDP-glucose 4,6-dehydratase activity
PARA_RS01355	COG3307	-O-antigen
PARA_RS01370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PARA_RS01375	COG0463	Glycosyl transferase, family 2
PARA_RS01380	COG1216	Glycosyl transferase, family 2
PARA_RS01380	COG1442	glycosyl transferase family 8
PARA_RS01395	COG2244	polysaccharide biosynthetic process
PARA_RS01400	COG1045	serine acetyltransferase
PARA_RS01415	COG2089	acid synthase
PARA_RS01425	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
PARA_RS01430	COG0174	glutamine synthetase
PARA_RS01435	COG1217	gtp-binding protein TYPA
PARA_RS01445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PARA_RS01450	COG2814	Major facilitator Superfamily
PARA_RS01455	COG4974	Belongs to the 'phage' integrase family
PARA_RS01465	COG2610	gluconate transmembrane transporter activity
PARA_RS01470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PARA_RS01475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PARA_RS01480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PARA_RS01485	COG1381	Involved in DNA repair and RecF pathway recombination
PARA_RS01495	COG3266	domain, Protein
PARA_RS01495	COG3061	Opacity-associated protein A
PARA_RS01500	COG1509	lysine 2,3-aminomutase activity
PARA_RS01515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PARA_RS01520	COG1882	Formate acetyltransferase
PARA_RS01525	COG2116	formate transmembrane transporter activity
PARA_RS01530	COG1555	photosystem II stabilization
PARA_RS01540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PARA_RS01585	COG1216	Glycosyl transferase, family 2
PARA_RS01605	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
PARA_RS01610	COG1011	Hydrolase
PARA_RS01620	COG0754	glutathionylspermidine amidase activity
PARA_RS01625	COG1979	alcohol dehydrogenase
PARA_RS01640	COG0250	Participates in transcription elongation, termination and antitermination
PARA_RS01645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PARA_RS01650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PARA_RS01665	COG1652	LysM domain
PARA_RS01670	COG2321	neutral zinc metallopeptidase
PARA_RS01680	COG0196	riboflavin kinase activity
PARA_RS01685	COG0728	peptidoglycan biosynthetic process
PARA_RS01695	COG0557	exoribonuclease II activity
PARA_RS01700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PARA_RS01705	COG1114	Component of the transport system for branched-chain amino acids
PARA_RS01715	COG1566	PFAM secretion protein HlyD family protein
PARA_RS01720	COG2814	Major facilitator Superfamily
PARA_RS01725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PARA_RS01730	COG0629	single-stranded DNA binding
PARA_RS01740	COG2116	formate transmembrane transporter activity
PARA_RS01750	COG3384	dioxygenase
PARA_RS01790	COG3715	PTS system
PARA_RS01795	COG3716	PTS system mannose fructose sorbose family IID component
PARA_RS01815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PARA_RS01820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PARA_RS01820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PARA_RS01830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PARA_RS01835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PARA_RS01840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PARA_RS01845	COG1120	ATPase activity
PARA_RS01870	COG0506	proline dehydrogenase activity
PARA_RS01870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PARA_RS01870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PARA_RS01880	COG2801	Transposase and inactivated derivatives
PARA_RS01910	COG0859	PFAM glycosyl transferase family 9
PARA_RS01915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PARA_RS01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PARA_RS01935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PARA_RS01950	COG0641	radical SAM
PARA_RS01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PARA_RS01960	COG3119	arylsulfatase activity
PARA_RS01965	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PARA_RS01970	COG0730	response to heat
PARA_RS01975	COG3956	TIGRFAM MazG family protein
PARA_RS01980	COG4695	Portal protein
PARA_RS02185	COG0582	viral genome integration into host DNA
PARA_RS02230	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
PARA_RS02235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PARA_RS02240	COG1739	Uncharacterized protein family UPF0029
PARA_RS02255	COG3276	selenocysteine insertion sequence binding
PARA_RS02265	COG3276	selenocysteine insertion sequence binding
PARA_RS02270	COG1921	L-seryl-tRNASec selenium transferase activity
PARA_RS02295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PARA_RS02305	COG0038	chloride channel
PARA_RS02310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PARA_RS02325	COG2129	metallophosphoesterase
PARA_RS02345	COG0210	DNA helicase
PARA_RS02350	COG5645	(Lipo)protein
PARA_RS02360	COG1519	Transferase
PARA_RS02365	COG0463	Glycosyl transferase, family 2
PARA_RS02370	COG4783	chaperone-mediated protein folding
PARA_RS02375	COG4783	chaperone-mediated protein folding
PARA_RS02385	COG2861	carbohydrate metabolic process
PARA_RS02390	COG4942	peptidase
PARA_RS02405	COG1187	pseudouridine synthase activity
PARA_RS02420	COG0583	DNA-binding transcription factor activity
PARA_RS02425	COG2962	Rard protein
PARA_RS02435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PARA_RS02440	COG0488	(ABC) transporter
PARA_RS02445	COG0551	DNA topoisomerase type I activity
PARA_RS02455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PARA_RS02460	COG2818	Glycosylase
PARA_RS02470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PARA_RS02475	COG0456	acetyltransferase
PARA_RS02485	COG2197	response regulator
PARA_RS02490	COG3072	Adenylate cyclase
PARA_RS02495	COG0181	hydroxymethylbilane synthase activity
PARA_RS02505	COG2959	enzyme of heme biosynthesis
PARA_RS02510	COG3071	HemY protein
PARA_RS02515	COG0765	amino acid transport
PARA_RS02520	COG0765	amino acid transport
PARA_RS02530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PARA_RS02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PARA_RS02570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PARA_RS02580	COG2168	tRNA wobble position uridine thiolation
PARA_RS02585	COG2923	Belongs to the DsrF TusC family
PARA_RS02590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PARA_RS02595	COG2964	Protein conserved in bacteria
PARA_RS02600	COG0545	Peptidyl-prolyl cis-trans isomerase
PARA_RS02610	COG3842	ATPase activity
PARA_RS02620	COG1176	ABC-type spermidine putrescine transport system, permease component I
PARA_RS02630	COG0471	metal ion transport
PARA_RS02635	COG2814	Major facilitator Superfamily
PARA_RS02640	COG2186	Transcriptional regulator
PARA_RS02645	COG0673	inositol 2-dehydrogenase activity
PARA_RS02650	COG0673	inositol 2-dehydrogenase activity
PARA_RS02660	COG0259	pyridoxamine-phosphate oxidase activity
PARA_RS02665	COG0747	negative chemotaxis
PARA_RS02670	COG2814	Major facilitator Superfamily
PARA_RS02675	COG1763	Mo-molybdopterin cofactor biosynthetic process
PARA_RS02680	COG3026	antisigma factor binding
PARA_RS02685	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
PARA_RS02690	COG1595	DNA-templated transcription, initiation
PARA_RS02700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PARA_RS02700	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PARA_RS02700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PARA_RS02705	COG1105	Belongs to the carbohydrate kinase PfkB family
PARA_RS02710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PARA_RS02710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PARA_RS02720	COG1253	flavin adenine dinucleotide binding
PARA_RS02730	COG0084	hydrolase, TatD family'
PARA_RS02735	COG0470	DNA polymerase III
PARA_RS02740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PARA_RS02745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PARA_RS02750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PARA_RS02760	COG0587	DNA-directed DNA polymerase activity
PARA_RS02775	COG2195	Cleaves the N-terminal amino acid of tripeptides
PARA_RS02785	COG0746	molybdenum cofactor guanylyltransferase activity
PARA_RS02790	COG3084	Protein conserved in bacteria
PARA_RS02795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PARA_RS02800	COG3085	chromosome segregation
PARA_RS02815	COG3086	response to oxidative stress
PARA_RS02820	COG0531	amino acid
PARA_RS02825	COG1982	Orn Lys Arg decarboxylase major
PARA_RS02830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PARA_RS02835	COG0737	Belongs to the 5'-nucleotidase family
PARA_RS02845	COG0733	neurotransmitter:sodium symporter activity
PARA_RS02860	COG0028	Belongs to the TPP enzyme family
PARA_RS02880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PARA_RS02890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PARA_RS02895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PARA_RS02900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PARA_RS02925	COG3312	ion transport
PARA_RS02935	COG1733	regulation of RNA biosynthetic process
PARA_RS02940	COG0702	epimerase
PARA_RS02950	COG0716	FMN binding
PARA_RS02955	COG3074	FtsZ-dependent cytokinesis
PARA_RS02960	COG1494	fructose-1,6-bisphosphatase
PARA_RS02970	COG1285	pathogenesis
PARA_RS02975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PARA_RS02980	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
PARA_RS02985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PARA_RS02995	COG2267	carboxylic ester hydrolase activity
PARA_RS03015	COG3033	Beta-eliminating lyase
PARA_RS03020	COG0814	amino acid
PARA_RS03035	COG2964	Protein conserved in bacteria
PARA_RS03050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PARA_RS03060	COG1238	metal cluster binding
PARA_RS03065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PARA_RS03075	COG0248	Ppx GppA phosphatase
PARA_RS03080	COG2911	Protein conserved in bacteria
PARA_RS03085	COG0729	surface antigen
PARA_RS03090	COG1490	D-aminoacyl-tRNA deacylase activity
PARA_RS03105	COG2258	MOSC domain
PARA_RS03110	COG0433	COG0433 Predicted ATPase
PARA_RS03115	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PARA_RS03120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PARA_RS03125	COG1045	serine acetyltransferase
PARA_RS03130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PARA_RS03135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PARA_RS03140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PARA_RS03145	COG0252	asparaginase activity
PARA_RS03150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PARA_RS03160	COG1288	antiporter activity
PARA_RS03180	COG4783	chaperone-mediated protein folding
PARA_RS03190	COG1132	(ABC) transporter
PARA_RS03195	COG1132	(ABC) transporter
PARA_RS03200	COG4774	siderophore transport
PARA_RS03200	COG1629	transport
PARA_RS03205	COG1309	transcriptional regulator
PARA_RS03210	COG2990	Protein conserved in bacteria
PARA_RS03215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PARA_RS03220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PARA_RS03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PARA_RS03235	COG1773	rubredoxin
PARA_RS03240	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PARA_RS03245	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PARA_RS03250	COG5557	Pfam Polysulphide reductase, NrfD
PARA_RS03255	COG0437	4 iron, 4 sulfur cluster binding
PARA_RS03260	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
PARA_RS03265	COG1704	LemA family
PARA_RS03275	COG0187	DNA topoisomerase II activity
PARA_RS03280	COG4988	ABC transporter
PARA_RS03285	COG1132	(ABC) transporter
PARA_RS03320	COG0561	phosphatase activity
PARA_RS03340	COG4667	esterase of the alpha-beta hydrolase superfamily
PARA_RS03345	COG3070	regulator of competence-specific genes
PARA_RS03375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PARA_RS03380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PARA_RS03380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PARA_RS03385	COG0463	Glycosyl transferase, family 2
PARA_RS03390	COG0569	domain protein
PARA_RS03395	COG1970	mechanosensitive ion channel activity
PARA_RS03415	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
PARA_RS03420	COG1309	transcriptional regulator
PARA_RS03425	COG0583	DNA-binding transcription factor activity
PARA_RS03430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PARA_RS03430	COG0678	peroxiredoxin activity
PARA_RS03440	COG0705	Rhomboid family
PARA_RS03445	COG1349	DNA-binding transcription factor activity
PARA_RS03450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PARA_RS03455	COG0742	ribosomal rna small subunit methyltransferase
PARA_RS03460	COG0552	protein localization to endoplasmic reticulum
PARA_RS03465	COG2884	Cell division ATP-binding protein ftsE
PARA_RS03470	COG2177	Part of the ABC transporter FtsEX involved in
PARA_RS03475	COG0051	transcription antitermination factor activity, RNA binding
PARA_RS03480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PARA_RS03500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PARA_RS03515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PARA_RS03560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PARA_RS03580	COG0201	protein transport
PARA_RS03615	COG0564	pseudouridine synthase activity
PARA_RS03625	COG3201	nicotinamide mononucleotide transporter
PARA_RS03630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PARA_RS03635	COG0513	Belongs to the DEAD box helicase family
PARA_RS03650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PARA_RS03690	COG0363	glucosamine-6-phosphate deaminase activity
PARA_RS03695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PARA_RS03700	COG1218	3'(2'),5'-bisphosphate nucleotidase
PARA_RS03710	COG1297	OPT oligopeptide transporter protein
PARA_RS03715	COG0494	nUDIX hydrolase
PARA_RS03720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PARA_RS03730	COG1322	Protein conserved in bacteria
PARA_RS03735	COG3700	Belongs to the class B bacterial acid phosphatase family
PARA_RS03750	COG1047	Peptidyl-prolyl cis-trans
PARA_RS03760	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PARA_RS03765	COG0585	pseudouridine synthase activity
PARA_RS03775	COG1238	metal cluster binding
PARA_RS03785	COG1388	LysM domain
PARA_RS03785	COG4942	peptidase
PARA_RS03790	COG0442	prolyl-tRNA aminoacylation
PARA_RS03795	COG4783	chaperone-mediated protein folding
PARA_RS03805	COG3266	domain, Protein
PARA_RS03810	COG0500	methyltransferase
PARA_RS03820	COG3059	membrane
PARA_RS03830	COG0584	glycerophosphoryl diester phosphodiesterase
PARA_RS03840	COG2271	Major facilitator Superfamily
PARA_RS03845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PARA_RS03855	COG0247	lactate metabolic process
PARA_RS03865	COG1522	sequence-specific DNA binding
PARA_RS03870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PARA_RS03875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PARA_RS03885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PARA_RS03895	COG0180	Tryptophanyl-tRNA synthetase
PARA_RS03900	COG3691	Protein conserved in bacteria
PARA_RS03905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PARA_RS03910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PARA_RS03920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PARA_RS03925	COG2183	response to ionizing radiation
PARA_RS03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PARA_RS03955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PARA_RS03960	COG1126	abc transporter atp-binding protein
PARA_RS03965	COG0765	amino acid transport
PARA_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PARA_RS03975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PARA_RS04005	COG0814	amino acid
PARA_RS04010	COG1435	thymidine kinase activity
PARA_RS04020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PARA_RS04030	COG0358	DNA primase activity
PARA_RS04035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PARA_RS04045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PARA_RS04050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PARA_RS04055	COG4972	Pilus assembly protein
PARA_RS04075	COG4796	Type ii and iii secretion system protein
PARA_RS04080	COG1040	competence protein
PARA_RS04090	COG0606	chelatase, subunit chli
PARA_RS04100	COG2990	Protein conserved in bacteria
PARA_RS04105	COG4608	Belongs to the ABC transporter superfamily
PARA_RS04110	COG0444	Belongs to the ABC transporter superfamily
PARA_RS04115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PARA_RS04120	COG0601	transmembrane transport
PARA_RS04125	COG4166	transmembrane transport
PARA_RS04130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PARA_RS04135	COG2853	Lipoprotein
PARA_RS04140	COG0251	oxidation-reduction process
PARA_RS04165	COG1464	Belongs to the NlpA lipoprotein family
PARA_RS04180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PARA_RS04215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PARA_RS04220	COG0019	diaminopimelate decarboxylase activity
PARA_RS04230	COG0514	ATP-dependent DNA helicase (RecQ)
PARA_RS04235	COG1328	CTP reductase activity
PARA_RS04240	COG2364	Membrane
PARA_RS04245	COG0859	PFAM glycosyl transferase family 9
PARA_RS04250	COG0191	fructose-bisphosphate aldolase activity
PARA_RS04260	COG0126	phosphoglycerate kinase activity
PARA_RS04265	COG3719	Belongs to the RNase T2 family
PARA_RS04270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PARA_RS04275	COG2814	Major facilitator Superfamily
PARA_RS04280	COG3850	Histidine kinase
PARA_RS04285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PARA_RS04295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PARA_RS04305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PARA_RS04310	COG1230	cation diffusion facilitator family transporter
PARA_RS04325	COG1116	anion transmembrane transporter activity
PARA_RS04340	COG2315	Protein conserved in bacteria
PARA_RS04345	COG5295	Hep Hag repeat protein
PARA_RS04345	COG5295	Hep Hag repeat protein
PARA_RS04345	COG5295	Hep Hag repeat protein
PARA_RS04350	COG1442	glycosyl transferase family 8
PARA_RS04370	COG0204	Acyl-transferase
PARA_RS04380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PARA_RS04385	COG1349	DNA-binding transcription factor activity
PARA_RS04390	COG0776	regulation of translation
PARA_RS04395	COG3068	Protein conserved in bacteria
PARA_RS04400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PARA_RS04420	COG0814	amino acid
PARA_RS04425	COG1561	YicC-like family, N-terminal region
PARA_RS04430	COG0354	folic acid binding
PARA_RS04435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PARA_RS04440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PARA_RS04445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PARA_RS04455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PARA_RS04460	COG1441	menaquinone biosynthetic process
PARA_RS04470	COG0511	ligase activity, forming carbon-carbon bonds
PARA_RS04475	COG0439	Biotin carboxylase
PARA_RS04485	COG3924	membrane
PARA_RS04490	COG4145	pantothenate transmembrane transporter activity
PARA_RS04495	COG0697	spore germination
PARA_RS04505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PARA_RS04510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PARA_RS04515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PARA_RS04520	COG0848	biopolymer transport protein
PARA_RS04525	COG0811	peptide transport
PARA_RS04530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PARA_RS04550	COG3036	rescue of stalled ribosome
PARA_RS04555	COG1393	Belongs to the ArsC family
PARA_RS04565	COG1720	tRNA m6t6A37 methyltransferase activity
PARA_RS04570	COG1575	Belongs to the MenA family. Type 1 subfamily
PARA_RS04580	COG0471	metal ion transport
PARA_RS04590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PARA_RS04600	COG4771	TonB-dependent receptor
PARA_RS04610	COG1194	a g-specific adenine glycosylase
PARA_RS04635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PARA_RS04640	COG0121	glutamine amidotransferase
PARA_RS04660	COG3338	carbonate dehydratase activity
PARA_RS04665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PARA_RS04670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PARA_RS04675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PARA_RS04680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PARA_RS04685	COG0659	secondary active sulfate transmembrane transporter activity
PARA_RS04710	COG1252	NADH dehydrogenase
PARA_RS04720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PARA_RS04755	COG3718	enzyme involved in inositol metabolism
PARA_RS04765	COG0673	inositol 2-dehydrogenase activity
PARA_RS04780	COG1129	ABC transporter
PARA_RS04785	COG1172	Belongs to the binding-protein-dependent transport system permease family
PARA_RS04790	COG0673	inositol 2-dehydrogenase activity
PARA_RS04800	COG3962	Belongs to the TPP enzyme family
PARA_RS04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PARA_RS04820	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PARA_RS04825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PARA_RS04830	COG1053	succinate dehydrogenase
PARA_RS04840	COG0814	amino acid
PARA_RS04845	COG1760	l-serine dehydratase
PARA_RS04850	COG1408	metallophosphoesterase
PARA_RS04855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PARA_RS04865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PARA_RS04870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PARA_RS04900	COG4735	regulation of single-species biofilm formation
PARA_RS04905	COG0646	methionine synthase
PARA_RS04905	COG1410	methionine synthase
PARA_RS04915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PARA_RS04930	COG0758	DNA mediated transformation
PARA_RS04935	COG3022	response to hydroperoxide
PARA_RS04950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PARA_RS04965	COG0545	Peptidyl-prolyl cis-trans isomerase
PARA_RS04970	COG0688	phosphatidylethanolamine metabolic process
PARA_RS04975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PARA_RS04980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PARA_RS04985	COG0754	glutathionylspermidine amidase activity
PARA_RS04990	COG3005	denitrification pathway
PARA_RS04995	COG3043	anaerobic respiration
PARA_RS05000	COG0348	domain, Protein
PARA_RS05005	COG0437	4 iron, 4 sulfur cluster binding
PARA_RS05010	COG0243	molybdopterin cofactor binding
PARA_RS05015	COG3062	negative regulation of establishment of protein localization
PARA_RS05020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PARA_RS05025	COG3171	Protein conserved in bacteria
PARA_RS05035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PARA_RS05040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PARA_RS05045	COG1309	transcriptional regulator
PARA_RS05050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PARA_RS05055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PARA_RS05065	COG0814	amino acid
PARA_RS05070	COG2226	methyltransferase
PARA_RS05085	COG2194	sulfuric ester hydrolase activity
PARA_RS05110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PARA_RS05115	COG0575	Belongs to the CDS family
PARA_RS05120	COG0750	zinc metalloprotease
PARA_RS05130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
PARA_RS05140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PARA_RS05150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PARA_RS05160	COG0490	domain, Protein
PARA_RS05160	COG0471	metal ion transport
PARA_RS05170	COG1027	Aspartate ammonia-lyase
PARA_RS05190	COG0006	proline dipeptidase activity
PARA_RS05195	COG0589	response to stress
PARA_RS05210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PARA_RS05215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PARA_RS05225	COG0789	Transcriptional regulator
PARA_RS05230	COG2608	mercury ion transmembrane transporter activity
PARA_RS05235	COG2217	Heavy metal translocating P-type atpase
PARA_RS05240	COG2205	protein histidine kinase activity
PARA_RS05245	COG0745	RESPONSE REGULATOR receiver
PARA_RS05250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PARA_RS05265	COG3083	sulfuric ester hydrolase activity
PARA_RS05270	COG0402	S-adenosylhomocysteine deaminase activity
PARA_RS05295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PARA_RS05305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PARA_RS05315	COG0741	lytic transglycosylase activity
PARA_RS05320	COG2350	Protein conserved in bacteria
PARA_RS05325	COG1607	acyl-coa hydrolase
PARA_RS05340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PARA_RS05350	COG3691	Protein conserved in bacteria
PARA_RS05360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PARA_RS05375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PARA_RS05385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PARA_RS05390	COG1121	(ABC) transporter
PARA_RS05395	COG0739	heme binding
PARA_RS05400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PARA_RS05405	COG4605	iron ion homeostasis
PARA_RS05410	COG4604	ABC transporter, ATP-binding protein
PARA_RS05415	COG4607	ABC-type enterochelin transport system periplasmic component
PARA_RS05420	COG3283	Transcriptional regulator of aromatic amino acids metabolism
PARA_RS05425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PARA_RS05435	COG0564	pseudouridine synthase activity
PARA_RS05440	COG1530	ribonuclease E activity
PARA_RS05455	COG2056	Na+-H+ antiporter family
PARA_RS05465	COG0346	lactoylglutathione lyase activity
PARA_RS05485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PARA_RS05500	COG0494	nUDIX hydrolase
PARA_RS05510	COG0641	radical SAM
PARA_RS05535	COG1271	oxidase subunit
PARA_RS05540	COG1294	oxidase, subunit
PARA_RS05550	COG0824	Thioesterase
PARA_RS05555	COG0811	peptide transport
PARA_RS05560	COG0848	biopolymer transport protein
PARA_RS05565	COG3064	Membrane
PARA_RS05575	COG2885	chlorophyll binding
PARA_RS05595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PARA_RS05600	COG1959	2 iron, 2 sulfur cluster binding
PARA_RS05610	COG0822	iron-sulfur transferase activity
PARA_RS05625	COG0316	Belongs to the HesB IscA family
PARA_RS05630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PARA_RS05640	COG0443	Heat shock 70 kDa protein
PARA_RS05645	COG0633	Ferredoxin
PARA_RS05650	COG2975	iron-sulfur cluster assembly
PARA_RS05660	COG4211	Belongs to the binding-protein-dependent transport system permease family
PARA_RS05665	COG1129	ABC transporter
PARA_RS05670	COG1879	ABC-type sugar transport system periplasmic component
PARA_RS05675	COG1609	Transcriptional regulator
PARA_RS05680	COG1085	galactose-1-phosphate uridylyltransferase
PARA_RS05685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PARA_RS05690	COG2017	converts alpha-aldose to the beta-anomer
PARA_RS05695	COG4535	Mg2 and Co2 transporter CorC
PARA_RS05700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PARA_RS05705	COG1127	ABC transporter
PARA_RS05710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PARA_RS05715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PARA_RS05720	COG2854	intermembrane phospholipid transfer
PARA_RS05725	COG3113	response to antibiotic
PARA_RS05730	COG5007	Belongs to the BolA IbaG family
PARA_RS05740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PARA_RS05745	COG0527	aspartate kinase activity
PARA_RS05745	COG0460	homoserine dehydrogenase
PARA_RS05755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PARA_RS05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PARA_RS05760	COG1263	PTS System
PARA_RS05760	COG2190	(PTS) system
PARA_RS05765	COG2091	lysine biosynthetic process via aminoadipic acid
PARA_RS05770	COG0330	HflC and HflK could
PARA_RS05775	COG0330	HflC and HflK could
PARA_RS05785	COG0477	Major facilitator Superfamily
PARA_RS05790	COG0352	thiamine-phosphate diphosphorylase activity
PARA_RS05795	COG0351	phosphomethylpyrimidine kinase
PARA_RS05805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PARA_RS05810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PARA_RS05815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PARA_RS05820	COG1116	anion transmembrane transporter activity
PARA_RS05825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PARA_RS05855	COG3077	Addiction module antitoxin, RelB DinJ family
PARA_RS05870	COG0583	DNA-binding transcription factor activity
PARA_RS05875	COG0786	glutamate:sodium symporter activity
PARA_RS05890	COG0640	Transcriptional regulator
PARA_RS06080	COG2003	Belongs to the UPF0758 family
PARA_RS06130	COG0629	single-stranded DNA binding
PARA_RS06185	COG0626	cystathionine gamma-synthase activity
PARA_RS06190	COG3118	belongs to the thioredoxin family
PARA_RS06195	COG1793	dna ligase
PARA_RS06205	COG1126	abc transporter atp-binding protein
PARA_RS06210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PARA_RS06215	COG4215	(ABC) transporter
PARA_RS06220	COG4160	amino acid transport
PARA_RS06235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PARA_RS06255	COG1674	ftsk spoiiie
PARA_RS06260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PARA_RS06285	COG1966	Carbon starvation protein
PARA_RS06295	COG0275	rRNA processing
PARA_RS06300	COG3116	cell division
PARA_RS06305	COG0768	penicillin binding
PARA_RS06315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PARA_RS06330	COG0772	Belongs to the SEDS family
PARA_RS06335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PARA_RS06350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PARA_RS06355	COG0849	cell division
PARA_RS06360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PARA_RS06365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PARA_RS06370	COG0737	Belongs to the 5'-nucleotidase family
PARA_RS06375	COG1605	Chorismate mutase
PARA_RS06375	COG0077	Prephenate dehydratase
PARA_RS06380	COG2824	Alkylphosphonate utilization operon protein PhnA
PARA_RS06385	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
PARA_RS06395	COG1595	DNA-templated transcription, initiation
PARA_RS06405	COG3219	Protein conserved in bacteria
PARA_RS06410	COG3220	belongs to the UPF0276 family
PARA_RS06420	COG2259	Doxx family
PARA_RS06435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PARA_RS06440	COG0084	hydrolase, TatD family'
PARA_RS06445	COG0602	queuosine metabolic process
PARA_RS06450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PARA_RS06455	COG4988	ABC transporter
PARA_RS06460	COG0492	ferredoxin-NADP+ reductase activity
PARA_RS06465	COG3118	belongs to the thioredoxin family
PARA_RS06475	COG0471	metal ion transport
PARA_RS06490	COG1573	uracil-dna glycosylase
PARA_RS06495	COG1328	CTP reductase activity
PARA_RS06495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PARA_RS06500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PARA_RS06510	COG0497	DNA recombination
PARA_RS06520	COG3091	SprT-like family
PARA_RS06525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PARA_RS06530	COG1393	Belongs to the ArsC family
PARA_RS06560	COG1876	peptidase activity
PARA_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PARA_RS06575	COG1137	ATPase activity
PARA_RS06580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PARA_RS06585	COG3117	lipopolysaccharide transmembrane transporter activity
PARA_RS06595	COG0312	modulator of DNA gyrase
PARA_RS06600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PARA_RS06610	COG1160	GTP binding
PARA_RS06625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PARA_RS06635	COG1946	Acyl-CoA thioesterase
PARA_RS06640	COG0012	GTP binding
PARA_RS06645	COG0193	aminoacyl-tRNA hydrolase activity
PARA_RS06660	COG2850	peptidyl-arginine hydroxylation
PARA_RS06670	COG0494	nUDIX hydrolase
PARA_RS06675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PARA_RS06700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PARA_RS06705	COG0450	alkyl hydroperoxide reductase
PARA_RS06710	COG0626	cystathionine gamma-synthase activity
PARA_RS06715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PARA_RS06720	COG5413	integral membrane protein
PARA_RS06730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PARA_RS06735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PARA_RS06740	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PARA_RS06750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PARA_RS06750	COG0475	glutathione-regulated potassium exporter activity
PARA_RS06760	COG2363	Small membrane protein
PARA_RS06765	COG1643	Atp-dependent helicase
PARA_RS06780	COG3069	C4-dicarboxylate transmembrane transporter activity
PARA_RS06785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PARA_RS06790	COG0617	tRNA 3'-terminal CCA addition
PARA_RS06795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PARA_RS06800	COG2333	competence protein COMEC
PARA_RS06800	COG0658	competence protein
PARA_RS06810	COG1663	tetraacyldisaccharide 4'-kinase activity
PARA_RS06815	COG2835	tetraacyldisaccharide 4'-kinase activity
PARA_RS06835	COG0861	Integral membrane protein TerC family
PARA_RS06840	COG3842	ATPase activity
PARA_RS06845	COG1178	ABC-type Fe3 transport system permease component
PARA_RS06850	COG1840	ABC-type Fe3 transport system, periplasmic component
PARA_RS06855	COG2918	glutathione biosynthetic process
PARA_RS06855	COG1181	Belongs to the D-alanine--D-alanine ligase family
PARA_RS06860	COG1702	phosphate starvation-inducible protein PhoH
PARA_RS06870	COG0561	phosphatase activity
PARA_RS06875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PARA_RS06885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PARA_RS06910	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
PARA_RS06915	COG0456	acetyltransferase
PARA_RS06925	COG2864	formate dehydrogenase
PARA_RS06930	COG0437	4 iron, 4 sulfur cluster binding
PARA_RS06950	COG1442	glycosyl transferase family 8
PARA_RS06955	COG1840	ABC-type Fe3 transport system, periplasmic component
PARA_RS06960	COG0210	DNA helicase
PARA_RS06965	COG0601	transmembrane transport
PARA_RS06970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PARA_RS06975	COG0444	Belongs to the ABC transporter superfamily
PARA_RS06980	COG4608	Belongs to the ABC transporter superfamily
PARA_RS06985	COG2814	Major facilitator Superfamily
PARA_RS07005	COG1840	ABC-type Fe3 transport system, periplasmic component
PARA_RS07010	COG1840	ABC-type Fe3 transport system, periplasmic component
PARA_RS07030	COG0583	DNA-binding transcription factor activity
PARA_RS07035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PARA_RS07040	COG1687	branched-chain amino acid
PARA_RS07070	COG0516	GMP reductase activity
PARA_RS07070	COG0517	IMP dehydrogenase activity
PARA_RS07075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PARA_RS07075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PARA_RS07110	COG2198	Histidine kinase
PARA_RS07110	COG5002	protein histidine kinase activity
PARA_RS07110	COG5002	protein histidine kinase activity
PARA_RS07110	COG0784	Response regulator, receiver
PARA_RS07110	COG0784	Response regulator, receiver
PARA_RS07110	COG2198	Histidine kinase
PARA_RS07115	COG1444	tRNA N-acetyltransferase activity
PARA_RS07120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PARA_RS07125	COG1090	epimerase
PARA_RS07130	COG1438	arginine binding
PARA_RS07135	COG0039	L-malate dehydrogenase activity
PARA_RS07140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PARA_RS07145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PARA_RS07160	COG4991	sh3 domain protein
PARA_RS07165	COG0306	phosphate transporter
PARA_RS07170	COG1392	Phosphate transport regulator
PARA_RS07175	COG3025	triphosphatase activity
PARA_RS07180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PARA_RS07185	COG1522	sequence-specific DNA binding
PARA_RS07195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PARA_RS07200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PARA_RS07205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PARA_RS07210	COG1177	transmembrane transport
PARA_RS07215	COG1176	ABC-type spermidine putrescine transport system, permease component I
PARA_RS07220	COG3842	ATPase activity
PARA_RS07225	COG2195	Cleaves the N-terminal amino acid of tripeptides
PARA_RS07230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PARA_RS07235	COG3108	Peptidase M15
PARA_RS07240	COG2989	Protein conserved in bacteria
PARA_RS07245	COG0793	Belongs to the peptidase S41A family
PARA_RS07250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PARA_RS07255	COG2995	paraquat-inducible protein a
PARA_RS07260	COG3008	intermembrane lipid transfer
PARA_RS07265	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PARA_RS07270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PARA_RS07270	COG0517	IMP dehydrogenase activity
PARA_RS07275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PARA_RS07285	COG2249	NAD(P)H dehydrogenase (quinone) activity
PARA_RS07325	COG3101	peptidyl-lysine hydroxylation
PARA_RS07330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PARA_RS07335	COG2890	protein-(glutamine-N5) methyltransferase activity
PARA_RS07340	COG2912	Transglutaminase-like superfamily
PARA_RS07350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PARA_RS07355	COG4591	ABC-type transport system involved in lipoprotein release permease component
PARA_RS07360	COG1136	(ABC) transporter
PARA_RS07365	COG4591	ABC-type transport system involved in lipoprotein release permease component
PARA_RS07370	COG3105	Protein conserved in bacteria
PARA_RS07375	COG0251	oxidation-reduction process
PARA_RS07385	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PARA_RS07390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PARA_RS07390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PARA_RS07395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PARA_RS07400	COG0028	Belongs to the TPP enzyme family
PARA_RS07405	COG0440	acetolactate synthase activity
PARA_RS07415	COG3842	ATPase activity
PARA_RS07420	COG1178	ABC-type Fe3 transport system permease component
PARA_RS07425	COG3842	ATPase activity
PARA_RS07445	COG0527	aspartate kinase activity
PARA_RS07450	COG2949	membrane
PARA_RS07460	COG0778	Nitroreductase
PARA_RS07465	COG0616	signal peptide processing
PARA_RS07470	COG0385	Bile acid
PARA_RS07475	COG4172	Belongs to the ABC transporter superfamily
PARA_RS07480	COG4172	Belongs to the ABC transporter superfamily
PARA_RS07485	COG4171	peptide transport system, permease
PARA_RS07490	COG4168	peptide transport system, permease
PARA_RS07495	COG4166	transmembrane transport
PARA_RS07500	COG3106	COG3106 Predicted ATPase
PARA_RS07510	COG2608	mercury ion transmembrane transporter activity
PARA_RS07520	COG1305	Transglutaminase-like
PARA_RS07540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PARA_RS07545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PARA_RS07550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PARA_RS07555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PARA_RS07560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PARA_RS07565	COG0539	negative regulation of cytoplasmic translation
PARA_RS07575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
PARA_RS07580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PARA_RS07590	COG0023	Translation Initiation Factor
PARA_RS07595	COG3094	Invasion gene expression up-regulator, SirB
PARA_RS07605	COG0488	(ABC) transporter
PARA_RS07610	COG3683	transport system, periplasmic component
PARA_RS07615	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
PARA_RS07620	COG0778	Nitroreductase
PARA_RS07625	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PARA_RS07640	COG4178	(ABC) transporter
PARA_RS07645	COG4774	siderophore transport
PARA_RS07655	COG0469	pyruvate kinase activity
PARA_RS07660	COG0305	Participates in initiation and elongation during chromosome replication
PARA_RS07665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PARA_RS07685	COG1621	beta-fructofuranosidase activity
PARA_RS07690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PARA_RS07700	COG2897	thiosulfate sulfurtransferase activity
PARA_RS07705	COG2391	methyltransferase activity
PARA_RS07720	COG0670	Belongs to the BI1 family
PARA_RS07725	COG1555	photosystem II stabilization
PARA_RS07730	COG0567	Dehydrogenase, E1 component
PARA_RS07735	COG0508	dehydrogenase complex catalyzes the overall conversion of
PARA_RS07750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PARA_RS07755	COG0009	L-threonylcarbamoyladenylate synthase
PARA_RS07760	COG1187	pseudouridine synthase activity
PARA_RS07765	COG0583	DNA-binding transcription factor activity
PARA_RS07775	COG2890	protein-(glutamine-N5) methyltransferase activity
PARA_RS07780	COG2840	Smr protein MutS2
PARA_RS07790	COG3102	Protein conserved in bacteria
PARA_RS07800	COG3133	Outer membrane lipoprotein
PARA_RS07820	COG0489	protein tyrosine kinase activity
PARA_RS07830	COG1538	Outer membrane efflux protein
PARA_RS07835	COG0577	efflux transmembrane transporter activity
PARA_RS07835	COG1136	(ABC) transporter
PARA_RS07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PARA_RS07855	COG1640	4-alpha-glucanotransferase
PARA_RS07860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PARA_RS07865	COG1523	belongs to the glycosyl hydrolase 13 family
PARA_RS07880	COG0058	SHG alpha-glucan phosphorylase activity
PARA_RS07885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PARA_RS07895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PARA_RS07900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PARA_RS07905	COG1280	lysine exporter protein (LysE YggA)
PARA_RS07920	COG0633	Ferredoxin
PARA_RS07930	COG3111	PFAM Bacterial OB fold (BOF) protein
PARA_RS07935	COG0745	RESPONSE REGULATOR receiver
PARA_RS07940	COG0642	Histidine kinase
PARA_RS07960	COG0195	Participates in both transcription termination and antitermination
PARA_RS07965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PARA_RS07975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PARA_RS07985	COG0287	Prephenate dehydrogenase
PARA_RS07985	COG1605	Chorismate mutase
PARA_RS07990	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PARA_RS07990	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PARA_RS07995	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PARA_RS08000	COG2166	iron-sulfur cluster assembly
PARA_RS08005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PARA_RS08010	COG1525	nuclease
PARA_RS08020	COG1346	cytolysis
PARA_RS08030	COG0488	(ABC) transporter
PARA_RS08035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PARA_RS08045	COG0732	type I restriction modification DNA specificity domain
PARA_RS08050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PARA_RS08055	COG0733	neurotransmitter:sodium symporter activity
PARA_RS08060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PARA_RS08080	COG4656	Part of a membrane complex involved in electron transport
PARA_RS08090	COG4657	Part of a membrane complex involved in electron transport
PARA_RS08095	COG1289	transmembrane transporter activity
PARA_RS08110	COG3098	single-species biofilm formation
PARA_RS08115	COG0564	pseudouridine synthase activity
PARA_RS08120	COG1278	Cold shock
PARA_RS08130	COG1067	ATP-dependent peptidase activity
PARA_RS08135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PARA_RS08140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PARA_RS08145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PARA_RS08150	COG2252	PERMEase
PARA_RS08155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PARA_RS08160	COG1074	ATP-dependent DNA helicase activity
PARA_RS08165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PARA_RS08170	COG2999	glutathione oxidoreductase activity
PARA_RS08175	COG2966	Psort location CytoplasmicMembrane, score
PARA_RS08180	COG3610	response to peptide
PARA_RS08195	COG0783	Belongs to the Dps family
PARA_RS08200	COG0747	negative chemotaxis
PARA_RS08205	COG0601	transmembrane transport
PARA_RS08210	COG0444	Belongs to the ABC transporter superfamily
PARA_RS08215	COG4608	Belongs to the ABC transporter superfamily
PARA_RS08230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PARA_RS08245	COG3585	molybdate ion transport
PARA_RS08255	COG1120	ATPase activity
PARA_RS08260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PARA_RS08290	COG1136	(ABC) transporter
PARA_RS08300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PARA_RS08325	COG2920	part of a sulfur-relay system
PARA_RS08345	COG1528	Iron-storage protein
PARA_RS08350	COG1528	Iron-storage protein
PARA_RS08355	COG2925	Exonuclease
PARA_RS08360	COG0697	spore germination
PARA_RS08370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
PARA_RS08375	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
PARA_RS08385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PARA_RS08390	COG0589	response to stress
PARA_RS08395	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
PARA_RS08405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PARA_RS08410	COG0583	DNA-binding transcription factor activity
PARA_RS08415	COG0613	PHP domain protein
PARA_RS08420	COG0167	dihydroorotate dehydrogenase activity
PARA_RS08425	COG4166	transmembrane transport
PARA_RS08430	COG0308	aminopeptidase N
PARA_RS08435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PARA_RS08440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PARA_RS08445	COG1448	Aminotransferase
PARA_RS08455	COG0314	molybdopterin synthase activity
PARA_RS08460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PARA_RS08465	COG0315	cyclic pyranopterin monophosphate synthase activity
PARA_RS08470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PARA_RS08490	COG0142	geranyltranstransferase activity
PARA_RS08495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PARA_RS08500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PARA_RS08505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PARA_RS08510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PARA_RS08515	COG0676	glucose-6-phosphate 1-epimerase activity
PARA_RS08530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PARA_RS08535	COG0512	Glutamine amidotransferase of anthranilate synthase
PARA_RS08540	COG1942	4-Oxalocrotonate Tautomerase
PARA_RS08550	COG0135	phosphoribosylanthranilate isomerase activity
PARA_RS08550	COG0134	indole-3-glycerol-phosphate synthase activity
PARA_RS08555	COG4221	oxidoreductase activity
PARA_RS08560	COG0133	tryptophan synthase activity
PARA_RS08575	COG2969	positive regulation of protein catabolic process
PARA_RS08580	COG0625	glutathione transferase activity
PARA_RS08595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PARA_RS08600	COG0791	NLP P60 protein
PARA_RS08605	COG0776	regulation of translation
PARA_RS08615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PARA_RS08630	COG0616	signal peptide processing
PARA_RS08640	COG0288	reversible hydration of carbon dioxide
PARA_RS08645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PARA_RS08660	COG2062	phosphohistidine phosphatase, SixA
PARA_RS08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PARA_RS08670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PARA_RS08675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PARA_RS08685	COG1534	Rna-binding protein
PARA_RS08690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PARA_RS08695	COG2027	D-alanyl-D-alanine carboxypeptidase
PARA_RS08700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PARA_RS08705	COG1286	toxin biosynthetic process
PARA_RS08710	COG3092	negative regulation of chromosome organization
PARA_RS08720	COG0857	belongs to the CobB CobQ family
PARA_RS08720	COG0280	phosphate acetyltransferase
PARA_RS08725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PARA_RS08730	COG0318	PFAM AMP-dependent synthetase and ligase
PARA_RS08735	COG3065	identical protein binding
PARA_RS08740	COG1214	PFAM Peptidase M22, glycoprotease
PARA_RS08745	COG1199	ATP-dependent helicase activity
PARA_RS08790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PARA_RS08795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PARA_RS08810	COG0024	Methionine aminopeptidase
PARA_RS08815	COG0316	Belongs to the HesB IscA family
PARA_RS08820	COG3112	Uncharacterised protein family (UPF0231)
PARA_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PARA_RS08830	COG0672	)-iron permease
PARA_RS08845	COG0577	efflux transmembrane transporter activity
PARA_RS08855	COG1136	(ABC) transporter
PARA_RS08855	COG0577	efflux transmembrane transporter activity
PARA_RS08890	COG4139	cobalamin transport
PARA_RS08895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PARA_RS08900	COG1858	cytochrome C peroxidase
PARA_RS08905	COG2951	lytic endotransglycosylase activity
PARA_RS08910	COG1216	Glycosyl transferase, family 2
PARA_RS08915	COG1216	Glycosyl transferase, family 2
PARA_RS08925	COG3306	glycosyltransferase involved in LPS biosynthesis
PARA_RS08950	COG3099	Belongs to the UPF0263 family
PARA_RS08955	COG0309	Hydrogenase expression formation protein (HypE)
PARA_RS08960	COG0409	Hydrogenase expression formation protein
PARA_RS08965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PARA_RS08970	COG0375	protein maturation
PARA_RS08975	COG0789	Transcriptional regulator
PARA_RS08980	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
PARA_RS08985	COG0310	cobalt ion transport
PARA_RS08990	COG0310	cobalt ion transport
PARA_RS08995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PARA_RS09000	COG1122	ATPase activity
PARA_RS09005	COG3383	formate dehydrogenase (NAD+) activity
PARA_RS09010	COG3383	formate dehydrogenase (NAD+) activity
PARA_RS09015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PARA_RS09025	COG3260	NADH ubiquinone oxidoreductase 20
PARA_RS09030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PARA_RS09035	COG3261	NADH dehydrogenase
PARA_RS09035	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PARA_RS09040	COG0651	ATP synthesis coupled electron transport
PARA_RS09045	COG4237	Hydrogenase 4 membrane
PARA_RS09050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PARA_RS09055	COG0650	Formate hydrogenlyase subunit 4
PARA_RS09060	COG0651	ATP synthesis coupled electron transport
PARA_RS09065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PARA_RS09070	COG0298	carbon dioxide binding
PARA_RS09075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PARA_RS09080	COG2431	L-lysine efflux transmembrane transporter activity
PARA_RS09085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PARA_RS09090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PARA_RS09105	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PARA_RS09110	COG0708	Exodeoxyribonuclease III
PARA_RS09120	COG0564	pseudouridine synthase activity
PARA_RS09130	COG1757	Na H antiporter
PARA_RS09135	COG2916	Histone family protein nucleoid-structuring protein H-NS
PARA_RS09140	COG0788	formyltetrahydrofolate deformylase activity
PARA_RS09150	COG2814	Major facilitator Superfamily
PARA_RS09160	COG0303	'Molybdopterin
PARA_RS09165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PARA_RS09175	COG2391	methyltransferase activity
PARA_RS09180	COG0425	Belongs to the sulfur carrier protein TusA family
PARA_RS09190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PARA_RS09195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PARA_RS09205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PARA_RS09210	COG3107	peptidoglycan biosynthetic process
PARA_RS09220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PARA_RS09225	COG2823	Periplasmic or secreted lipoprotein
PARA_RS09230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PARA_RS09240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PARA_RS09250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PARA_RS09255	COG0402	S-adenosylhomocysteine deaminase activity
PARA_RS09260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PARA_RS09265	COG1914	H( )-stimulated, divalent metal cation uptake system
PARA_RS09270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PARA_RS09275	COG1984	allophanate hydrolase subunit 2
PARA_RS09280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PARA_RS09290	COG0795	lipopolysaccharide-transporting ATPase activity
PARA_RS09295	COG0795	lipopolysaccharide-transporting ATPase activity
PARA_RS09310	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
PARA_RS09315	COG1368	sulfuric ester hydrolase activity
PARA_RS09320	COG0281	malic enzyme
PARA_RS09320	COG0280	phosphate acetyltransferase
PARA_RS09325	COG3955	Domain of unknown function (DUF1919)
PARA_RS09330	COG1187	pseudouridine synthase activity
PARA_RS09335	COG2814	Major facilitator Superfamily
PARA_RS09340	COG1115	amino acid carrier protein
PARA_RS09350	COG0671	phosphoesterase, PA-phosphatase related
PARA_RS09365	COG0187	DNA topoisomerase II activity
PARA_RS09375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PARA_RS09380	COG0786	glutamate:sodium symporter activity
PARA_RS09385	COG0285	dihydrofolate synthase activity
PARA_RS09400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PARA_RS09405	COG0586	Pfam SNARE associated Golgi protein
PARA_RS09425	COG0307	riboflavin synthase, alpha
PARA_RS09430	COG0534	Mate efflux family protein
PARA_RS09435	COG1530	ribonuclease E activity
PARA_RS09440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PARA_RS09465	COG0583	DNA-binding transcription factor activity
PARA_RS09470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PARA_RS09475	COG3630	sodium ion export across plasma membrane
PARA_RS09480	COG5016	pyruvate
PARA_RS09480	COG0511	ligase activity, forming carbon-carbon bonds
PARA_RS09490	COG0204	Acyl-transferase
PARA_RS09490	COG0318	PFAM AMP-dependent synthetase and ligase
PARA_RS09500	COG4166	transmembrane transport
PARA_RS09510	COG0339	signal peptide processing
PARA_RS09520	COG0157	Belongs to the NadC ModD family
PARA_RS09525	COG1120	ATPase activity
PARA_RS09535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PARA_RS09550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PARA_RS09550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PARA_RS09555	COG1560	Kdo2-lipid A biosynthetic process
PARA_RS09560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PARA_RS09565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PARA_RS09575	COG1263	PTS System
PARA_RS09575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PARA_RS09575	COG2190	(PTS) system
PARA_RS09585	COG0058	SHG alpha-glucan phosphorylase activity
PARA_RS09590	COG1640	4-alpha-glucanotransferase
PARA_RS09595	COG1609	Transcriptional regulator
PARA_RS09600	COG1275	C4-dicarboxylate transporter malic acid transport protein
PARA_RS09610	COG2841	Protein conserved in bacteria
PARA_RS09625	COG2860	membrane
PARA_RS09635	COG2354	Protein conserved in bacteria
PARA_RS09640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PARA_RS09650	COG1560	Kdo2-lipid A biosynthetic process
PARA_RS09655	COG0730	response to heat
PARA_RS09660	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
PARA_RS09670	COG3264	Mechanosensitive ion channel
PARA_RS09670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PARA_RS09675	COG0318	PFAM AMP-dependent synthetase and ligase
PARA_RS09680	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PARA_RS09685	COG0596	Alpha beta hydrolase
PARA_RS09690	COG0716	FMN binding
PARA_RS09695	COG0735	belongs to the Fur family
PARA_RS09700	COG0137	argininosuccinate synthase activity
PARA_RS09705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PARA_RS09745	COG3698	Phosphodiester glycosidase
PARA_RS09750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PARA_RS09755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PARA_RS09760	COG2226	methyltransferase
PARA_RS09770	COG1944	ATP diphosphatase activity
PARA_RS09775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PARA_RS09780	COG3381	protein complex oligomerization
PARA_RS09785	COG2249	NAD(P)H dehydrogenase (quinone) activity
PARA_RS09795	COG0330	HflC and HflK could
PARA_RS09800	COG1119	ATPase activity
PARA_RS09810	COG2932	Transcriptional regulator
PARA_RS09815	COG0791	NLP P60 protein
PARA_RS09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PARA_RS09825	COG0508	dehydrogenase complex catalyzes the overall conversion of
PARA_RS09830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PARA_RS09840	COG5339	Protein conserved in bacteria
PARA_RS09845	COG0443	Heat shock 70 kDa protein
PARA_RS09860	COG0484	heat shock protein binding
PARA_RS09865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PARA_RS09870	COG4149	molybdate abc transporter
PARA_RS09875	COG0725	ABC transporter, periplasmic molybdate-binding protein
PARA_RS09880	COG2005	Transcriptional regulator
PARA_RS09890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PARA_RS09895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PARA_RS09895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PARA_RS09905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PARA_RS09920	COG4795	General secretion pathway protein
PARA_RS09925	COG2165	general secretion pathway protein
PARA_RS09930	COG0483	inositol monophosphate 1-phosphatase activity
PARA_RS09940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
PARA_RS09945	COG1178	ABC-type Fe3 transport system permease component
PARA_RS09950	COG4143	(ABC) transporter
PARA_RS09960	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PARA_RS09970	COG1704	LemA family
PARA_RS09980	COG0277	FAD linked oxidase domain protein
PARA_RS09980	COG0247	lactate metabolic process
PARA_RS09985	COG2050	protein possibly involved in aromatic compounds catabolism
PARA_RS09990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PARA_RS10035	COG2927	DNA polymerase III (CHI subunit)
PARA_RS10040	COG0114	fumarate hydratase activity
PARA_RS10045	COG2268	Band 7 protein
PARA_RS10055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PARA_RS10065	COG1482	cell wall glycoprotein biosynthetic process
PARA_RS10070	COG2190	(PTS) system
PARA_RS10075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PARA_RS10080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PARA_RS10085	COG1162	GTPase activity
PARA_RS10105	COG0802	atpase or kinase
PARA_RS10110	COG1388	LysM domain
PARA_RS10110	COG0860	N-Acetylmuramoyl-L-alanine amidase
PARA_RS10125	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PARA_RS10155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PARA_RS10160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PARA_RS10165	COG1758	RNA polymerase activity
PARA_RS10180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PARA_RS10180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity