locus-tag	class	description
HS_RS00060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HS_RS00065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HS_RS00070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HS_RS00075	COG0009	L-threonylcarbamoyladenylate synthase
HS_RS00080	COG0551	DNA topoisomerase type I activity
HS_RS00085	COG1678	Uncharacterized ACR, COG1678
HS_RS00095	COG1349	DNA-binding transcription factor activity
HS_RS00100	COG2084	Dehydrogenase
HS_RS00105	COG3395	kinase activity
HS_RS00110	COG0235	Class ii aldolase
HS_RS00115	COG3622	Belongs to the hyi family
HS_RS00120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS_RS00125	COG2610	gluconate transmembrane transporter activity
HS_RS00140	COG2186	Transcriptional regulator
HS_RS00145	COG1063	alcohol dehydrogenase
HS_RS00150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HS_RS00155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HS_RS00160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HS_RS00165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HS_RS00170	COG1984	allophanate hydrolase subunit 2
HS_RS00175	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HS_RS00180	COG1914	H( )-stimulated, divalent metal cation uptake system
HS_RS00195	COG1129	ABC transporter
HS_RS00200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS_RS00205	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS_RS00215	COG0678	peroxiredoxin activity
HS_RS00215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HS_RS00220	COG0583	DNA-binding transcription factor activity
HS_RS00230	COG0569	domain protein
HS_RS00240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HS_RS00245	COG0242	peptide deformylase activity
HS_RS00250	COG2197	response regulator
HS_RS00275	COG3071	HemY protein
HS_RS00290	COG2390	Transcriptional regulator
HS_RS00295	COG1129	ABC transporter
HS_RS00330	COG0051	transcription antitermination factor activity, RNA binding
HS_RS00340	COG0088	Forms part of the polypeptide exit tunnel
HS_RS00345	COG0089	rRNA binding
HS_RS00350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HS_RS00355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HS_RS00360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HS_RS00365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HS_RS00415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HS_RS00430	COG1841	ribosomal large subunit assembly
HS_RS00440	COG0201	protein transport
HS_RS00450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HS_RS00455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HS_RS00460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HS_RS00465	COG0202	RNA polymerase activity
HS_RS00475	COG2129	metallophosphoesterase
HS_RS00480	COG3172	ATPase kinase involved in NAD metabolism
HS_RS00490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS_RS00495	COG0352	thiamine-phosphate diphosphorylase activity
HS_RS00500	COG0351	phosphomethylpyrimidine kinase
HS_RS00505	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HS_RS00510	COG1381	Involved in DNA repair and RecF pathway recombination
HS_RS00515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS_RS00520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HS_RS00525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HS_RS00560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
HS_RS00575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS_RS00590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HS_RS00595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HS_RS00645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HS_RS00650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HS_RS00655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HS_RS00660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HS_RS00665	COG1555	photosystem II stabilization
HS_RS00670	COG0251	oxidation-reduction process
HS_RS00675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HS_RS00680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HS_RS00685	COG0512	Glutamine amidotransferase of anthranilate synthase
HS_RS00690	COG0783	Belongs to the Dps family
HS_RS00695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HS_RS00700	COG0706	membrane insertase activity
HS_RS00720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HS_RS00725	COG0592	DNA-directed DNA polymerase activity
HS_RS00730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS_RS00755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HS_RS00775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HS_RS00785	COG3978	acetolactate synthase activity
HS_RS00790	COG2258	MOSC domain
HS_RS00795	COG3161	chorismate lyase activity
HS_RS00800	COG0557	exoribonuclease II activity
HS_RS00815	COG1045	serine acetyltransferase
HS_RS00825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HS_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS_RS00835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HS_RS00840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HS_RS00855	COG0705	Rhomboid family
HS_RS00860	COG1399	metal-binding, possibly nucleic acid-binding protein
HS_RS00870	COG0416	fatty acid biosynthetic process
HS_RS00875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS_RS00880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HS_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
HS_RS00900	COG0081	regulation of translation
HS_RS00905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HS_RS00915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HS_RS00920	COG0513	Belongs to the DEAD box helicase family
HS_RS00925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HS_RS00945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS_RS00960	COG2860	membrane
HS_RS00975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HS_RS00980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HS_RS00990	COG0196	riboflavin kinase activity
HS_RS00995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HS_RS01000	COG3610	response to peptide
HS_RS01005	COG2966	Psort location CytoplasmicMembrane, score
HS_RS01010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HS_RS01020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HS_RS01050	COG1072	(Pantothenic acid kinase))
HS_RS01055	COG0786	glutamate:sodium symporter activity
HS_RS01085	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HS_RS01090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HS_RS01095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HS_RS01100	COG0191	fructose-bisphosphate aldolase activity
HS_RS01110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HS_RS01120	COG1126	abc transporter atp-binding protein
HS_RS01125	COG0765	amino acid transport
HS_RS01130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS_RS01145	COG3177	Filamentation induced by cAMP protein fic
HS_RS01155	COG0471	metal ion transport
HS_RS01160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HS_RS01165	COG1575	Belongs to the MenA family. Type 1 subfamily
HS_RS01170	COG1720	tRNA m6t6A37 methyltransferase activity
HS_RS01175	COG1869	D-ribose catabolic process
HS_RS01180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS_RS01190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS_RS01195	COG3081	Nucleoid-associated protein
HS_RS01205	COG3083	sulfuric ester hydrolase activity
HS_RS01210	COG1489	DNA binding
HS_RS01215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HS_RS01220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HS_RS01225	COG1368	sulfuric ester hydrolase activity
HS_RS01235	COG2017	converts alpha-aldose to the beta-anomer
HS_RS01250	COG0084	hydrolase, TatD family'
HS_RS01255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HS_RS01260	COG0215	cysteine-tRNA ligase activity
HS_RS01265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HS_RS01270	COG0142	geranyltranstransferase activity
HS_RS01285	COG0697	spore germination
HS_RS01290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HS_RS01295	COG3023	N-Acetylmuramoyl-L-alanine amidase
HS_RS01300	COG4969	Belongs to the N-Me-Phe pilin family
HS_RS01305	COG1126	abc transporter atp-binding protein
HS_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS_RS01315	COG4215	(ABC) transporter
HS_RS01320	COG4160	amino acid transport
HS_RS01330	COG1271	oxidase subunit
HS_RS01335	COG1294	oxidase, subunit
HS_RS01340	COG0824	Thioesterase
HS_RS01345	COG0811	peptide transport
HS_RS01350	COG0848	biopolymer transport protein
HS_RS01355	COG3064	Membrane
HS_RS01360	COG0823	Involved in the tonB-independent uptake of proteins
HS_RS01385	COG2165	general secretion pathway protein
HS_RS01390	COG4795	General secretion pathway protein
HS_RS01405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HS_RS01420	COG2081	HI0933 family
HS_RS01425	COG0500	methyltransferase
HS_RS01430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HS_RS01435	COG1530	ribonuclease E activity
HS_RS01450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HS_RS01450	COG4797	methyltransferase
HS_RS01460	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HS_RS01465	COG1959	2 iron, 2 sulfur cluster binding
HS_RS01470	COG1104	cysteine desulfurase activity
HS_RS01475	COG0822	iron-sulfur transferase activity
HS_RS01485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HS_RS01490	COG0443	Heat shock 70 kDa protein
HS_RS01495	COG0633	Ferredoxin
HS_RS01500	COG2918	glutathione biosynthetic process
HS_RS01500	COG1181	Belongs to the D-alanine--D-alanine ligase family
HS_RS01505	COG0813	purine-nucleoside phosphorylase activity
HS_RS01510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HS_RS01515	COG2364	Membrane
HS_RS01520	COG0463	Glycosyl transferase, family 2
HS_RS01525	COG0438	transferase activity, transferring glycosyl groups
HS_RS01530	COG0228	four-way junction DNA binding
HS_RS01535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HS_RS01555	COG1609	Transcriptional regulator
HS_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HS_RS01565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HS_RS01570	COG2176	DNA-directed DNA polymerase activity
HS_RS01580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS_RS01590	COG0742	ribosomal rna small subunit methyltransferase
HS_RS01595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS_RS01600	COG3085	chromosome segregation
HS_RS01605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS_RS01610	COG3084	Protein conserved in bacteria
HS_RS01615	COG0746	molybdenum cofactor guanylyltransferase activity
HS_RS01620	COG1297	OPT oligopeptide transporter protein
HS_RS01645	COG0321	lipoyl(octanoyl) transferase activity
HS_RS01655	COG1686	Belongs to the peptidase S11 family
HS_RS01665	COG0772	Belongs to the SEDS family
HS_RS01670	COG0768	penicillin binding
HS_RS01675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HS_RS01680	COG0799	negative regulation of ribosome biogenesis
HS_RS01685	COG3676	manually curated
HS_RS01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS_RS01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS_RS01700	COG1121	(ABC) transporter
HS_RS01710	COG2920	part of a sulfur-relay system
HS_RS01725	COG0606	chelatase, subunit chli
HS_RS01730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HS_RS01735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS_RS01745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HS_RS01760	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HS_RS01765	COG0729	surface antigen
HS_RS01770	COG2911	Protein conserved in bacteria
HS_RS01775	COG0248	Ppx GppA phosphatase
HS_RS01780	COG0129	dihydroxy-acid dehydratase activity
HS_RS01790	COG0387	Pfam Sodium calcium exchanger
HS_RS01800	COG1702	phosphate starvation-inducible protein PhoH
HS_RS01805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HS_RS01810	COG1444	tRNA N-acetyltransferase activity
HS_RS01815	COG1966	Carbon starvation protein
HS_RS01820	COG2001	Belongs to the MraZ family
HS_RS01825	COG0275	rRNA processing
HS_RS01830	COG3116	cell division
HS_RS01835	COG0768	penicillin binding
HS_RS01840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HS_RS01845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HS_RS01865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HS_RS01870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HS_RS01875	COG1181	Belongs to the D-alanine--D-alanine ligase family
HS_RS01880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HS_RS01885	COG0849	cell division
HS_RS01890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HS_RS01895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HS_RS01900	COG0077	Prephenate dehydratase
HS_RS01900	COG1605	Chorismate mutase
HS_RS01915	COG1496	oxidoreductase activity
HS_RS01920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HS_RS01930	COG3115	cell septum assembly
HS_RS01935	COG0488	(ABC) transporter
HS_RS01950	COG0569	domain protein
HS_RS01955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HS_RS01960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HS_RS01965	COG2610	gluconate transmembrane transporter activity
HS_RS01970	COG3265	gluconokinase activity
HS_RS01975	COG2358	TRAP transporter, solute receptor (TAXI family
HS_RS01995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HS_RS02000	COG2937	Belongs to the GPAT DAPAT family
HS_RS02010	COG0105	UTP biosynthetic process
HS_RS02035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS_RS02040	COG4133	protoheme IX ABC transporter activity
HS_RS02045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS_RS02050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS_RS02055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS_RS02060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HS_RS02065	COG1138	Cytochrome C-type biogenesis protein
HS_RS02085	COG5002	protein histidine kinase activity
HS_RS02085	COG0784	Response regulator, receiver
HS_RS02085	COG2198	Histidine kinase
HS_RS02090	COG1426	Protein conserved in bacteria
HS_RS02100	COG0124	histidyl-tRNA synthetase
HS_RS02105	COG2976	Protein conserved in bacteria
HS_RS02115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HS_RS02120	COG2860	membrane
HS_RS02135	COG0758	DNA mediated transformation
HS_RS02140	COG0742	ribosomal rna small subunit methyltransferase
HS_RS02145	COG0552	protein localization to endoplasmic reticulum
HS_RS02150	COG0728	peptidoglycan biosynthetic process
HS_RS02160	COG1217	gtp-binding protein TYPA
HS_RS02170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HS_RS02170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HS_RS02180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HS_RS02180	COG0519	Catalyzes the synthesis of GMP from XMP
HS_RS02195	COG0582	viral genome integration into host DNA
HS_RS02250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HS_RS02260	COG0489	protein tyrosine kinase activity
HS_RS02295	COG4783	chaperone-mediated protein folding
HS_RS02320	COG0326	Molecular chaperone. Has ATPase activity
HS_RS02345	COG2091	lysine biosynthetic process via aminoadipic acid
HS_RS02355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS_RS02375	COG1459	type II secretion system
HS_RS02380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HS_RS02390	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HS_RS02395	COG1115	amino acid carrier protein
HS_RS02400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HS_RS02405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HS_RS02415	COG0280	phosphate acetyltransferase
HS_RS02415	COG0281	malic enzyme
HS_RS02420	COG1027	Aspartate ammonia-lyase
HS_RS02440	COG3078	GTPase activator activity
HS_RS02450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HS_RS02460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HS_RS02465	COG0626	cystathionine gamma-synthase activity
HS_RS02470	COG0450	alkyl hydroperoxide reductase
HS_RS02485	COG0751	glycine-tRNA ligase activity
HS_RS02500	COG3022	response to hydroperoxide
HS_RS02520	COG0675	Transposase, IS605 OrfB family
HS_RS02525	COG0330	HflC and HflK could
HS_RS02530	COG0330	HflC and HflK could
HS_RS02535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HS_RS02540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HS_RS02545	COG0456	acetyltransferase
HS_RS02550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HS_RS02555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS_RS02560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HS_RS02565	COG0583	DNA-binding transcription factor activity
HS_RS02570	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HS_RS02575	COG0210	DNA helicase
HS_RS02580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS_RS02585	COG0204	Acyl-transferase
HS_RS02595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HS_RS02600	COG0346	lactoylglutathione lyase activity
HS_RS02605	COG0012	GTP binding
HS_RS02610	COG0193	aminoacyl-tRNA hydrolase activity
HS_RS02615	COG2867	negative regulation of translational initiation
HS_RS02625	COG0494	nUDIX hydrolase
HS_RS02630	COG0217	transcriptional regulatory protein
HS_RS02635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HS_RS02640	COG0584	glycerophosphoryl diester phosphodiesterase
HS_RS02645	COG2271	Major facilitator Superfamily
HS_RS02650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HS_RS02655	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HS_RS02660	COG0247	lactate metabolic process
HS_RS02665	COG1349	DNA-binding transcription factor activity
HS_RS02670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HS_RS02675	COG0795	lipopolysaccharide-transporting ATPase activity
HS_RS02680	COG0795	lipopolysaccharide-transporting ATPase activity
HS_RS02805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HS_RS02820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HS_RS02830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS_RS02835	COG0805	protein transport
HS_RS02845	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HS_RS02850	COG1854	S-ribosylhomocysteine lyase activity
HS_RS02860	COG0504	CTP synthase activity
HS_RS02865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HS_RS02895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HS_RS02930	COG2264	protein methyltransferase activity
HS_RS02935	COG4145	pantothenate transmembrane transporter activity
HS_RS02940	COG3924	membrane
HS_RS02945	COG0439	Biotin carboxylase
HS_RS02950	COG0511	ligase activity, forming carbon-carbon bonds
HS_RS02960	COG0330	HflC and HflK could
HS_RS02970	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS_RS02975	COG3381	protein complex oligomerization
HS_RS02980	COG1560	Kdo2-lipid A biosynthetic process
HS_RS02985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HS_RS02985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HS_RS02990	COG1393	Belongs to the ArsC family
HS_RS02995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS_RS03000	COG1876	peptidase activity
HS_RS03005	COG0494	nUDIX hydrolase
HS_RS03010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HS_RS03020	COG0675	Transposase, IS605 OrfB family
HS_RS03025	COG4214	carbohydrate transport
HS_RS03030	COG1129	ABC transporter
HS_RS03035	COG4213	ABC transporter substrate-binding protein
HS_RS03045	COG1070	Carbohydrate kinase
HS_RS03055	COG4172	Belongs to the ABC transporter superfamily
HS_RS03060	COG4172	Belongs to the ABC transporter superfamily
HS_RS03065	COG4171	peptide transport system, permease
HS_RS03070	COG4168	peptide transport system, permease
HS_RS03075	COG4166	transmembrane transport
HS_RS03080	COG3106	COG3106 Predicted ATPase
HS_RS03085	COG3768	UPF0283 membrane protein
HS_RS03090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HS_RS03095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HS_RS03100	COG0187	DNA topoisomerase II activity
HS_RS03105	COG2814	Major facilitator Superfamily
HS_RS03110	COG2252	PERMEase
HS_RS03130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HS_RS03135	COG0328	RNA-DNA hybrid ribonuclease activity
HS_RS03140	COG1482	cell wall glycoprotein biosynthetic process
HS_RS03150	COG3716	PTS system mannose fructose sorbose family IID component
HS_RS03155	COG3715	PTS system
HS_RS03160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS_RS03160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS_RS03165	COG2926	Belongs to the UPF0265 family
HS_RS03170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HS_RS03180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HS_RS03185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS_RS03190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS_RS03195	COG2267	carboxylic ester hydrolase activity
HS_RS03200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HS_RS03210	COG0436	Aminotransferase
HS_RS03230	COG4783	chaperone-mediated protein folding
HS_RS03240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HS_RS03260	COG4245	von Willebrand factor, type A
HS_RS03330	COG3842	ATPase activity
HS_RS03340	COG1840	ABC-type Fe3 transport system, periplasmic component
HS_RS03345	COG3676	manually curated
HS_RS03350	COG1840	ABC-type Fe3 transport system, periplasmic component
HS_RS03370	COG0385	Bile acid
HS_RS03390	COG0497	DNA recombination
HS_RS03400	COG0251	oxidation-reduction process
HS_RS03410	COG0189	ligase activity
HS_RS03415	COG1663	tetraacyldisaccharide 4'-kinase activity
HS_RS03420	COG2835	tetraacyldisaccharide 4'-kinase activity
HS_RS03425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HS_RS03430	COG0322	excinuclease ABC activity
HS_RS03435	COG2314	TM2 domain
HS_RS03445	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HS_RS03450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HS_RS03455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HS_RS03455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS_RS03460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS_RS03480	COG1476	TRANSCRIPTIONal
HS_RS03485	COG0287	Prephenate dehydrogenase
HS_RS03485	COG1605	Chorismate mutase
HS_RS03490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HS_RS03495	COG1349	DNA-binding transcription factor activity
HS_RS03500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS_RS03505	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
HS_RS03525	COG3730	PTS system glucitol sorbitol-specific
HS_RS03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS_RS03540	COG0006	proline dipeptidase activity
HS_RS03555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HS_RS03565	COG0560	Phosphoserine phosphatase
HS_RS03570	COG1666	GTP binding
HS_RS03580	COG0848	biopolymer transport protein
HS_RS03585	COG0811	peptide transport
HS_RS03590	COG0165	Argininosuccinate lyase
HS_RS03595	COG1295	ribonuclease BN
HS_RS03610	COG1737	Transcriptional regulator
HS_RS03615	COG2731	YhcH YjgK YiaL family protein
HS_RS03625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HS_RS03635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HS_RS03650	COG0513	Belongs to the DEAD box helicase family
HS_RS03665	COG1088	dTDP-glucose 4,6-dehydratase activity
HS_RS03670	COG1620	l-lactate permease
HS_RS03675	COG0247	lactate metabolic process
HS_RS03680	COG1139	Iron-sulfur cluster binding protein
HS_RS03685	COG1556	Lactate utilization protein
HS_RS03695	COG0745	RESPONSE REGULATOR receiver
HS_RS03705	COG1530	ribonuclease E activity
HS_RS03720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS_RS03720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS_RS03725	COG0210	DNA helicase
HS_RS03750	COG0748	coenzyme F420 binding
HS_RS03755	COG3721	Heme iron utilization protein
HS_RS03760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HS_RS03765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS_RS03775	COG1629	transport
HS_RS03780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HS_RS03785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS_RS03790	COG2062	phosphohistidine phosphatase, SixA
HS_RS03800	COG1199	ATP-dependent helicase activity
HS_RS03805	COG1214	PFAM Peptidase M22, glycoprotease
HS_RS03810	COG0318	PFAM AMP-dependent synthetase and ligase
HS_RS03815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HS_RS03820	COG2823	Periplasmic or secreted lipoprotein
HS_RS03825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HS_RS03830	COG0792	nuclease activity
HS_RS03835	COG3107	peptidoglycan biosynthetic process
HS_RS03845	COG0009	L-threonylcarbamoyladenylate synthase
HS_RS03865	COG1538	Outer membrane efflux protein
HS_RS03870	COG1349	DNA-binding transcription factor activity
HS_RS03880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS_RS03885	COG0738	Major facilitator superfamily
HS_RS03895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HS_RS03910	COG2969	positive regulation of protein catabolic process
HS_RS03915	COG0017	Asparaginyl-tRNA synthetase
HS_RS03920	COG1940	carbohydrate kinase activity
HS_RS03925	COG1414	Transcriptional regulator
HS_RS03935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HS_RS03940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HS_RS03945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HS_RS03950	COG1129	ABC transporter
HS_RS03970	COG1879	ABC-type sugar transport system periplasmic component
HS_RS03980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS_RS03990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HS_RS03995	COG3623	hexulose-6-phosphate isomerase
HS_RS04000	COG0235	Class ii aldolase
HS_RS04005	COG0561	phosphatase activity
HS_RS04010	COG2267	carboxylic ester hydrolase activity
HS_RS04020	COG0561	phosphatase activity
HS_RS04025	COG0778	Nitroreductase
HS_RS04030	COG3691	Protein conserved in bacteria
HS_RS04035	COG0814	amino acid
HS_RS04040	COG3842	ATPase activity
HS_RS04050	COG1840	ABC-type Fe3 transport system, periplasmic component
HS_RS04055	COG0277	FAD linked oxidase domain protein
HS_RS04065	COG0788	formyltetrahydrofolate deformylase activity
HS_RS04075	COG1757	Na H antiporter
HS_RS04090	COG0339	signal peptide processing
HS_RS04095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HS_RS04100	COG1757	Na H antiporter
HS_RS04105	COG2207	Transcriptional regulator
HS_RS04105	COG1609	Transcriptional regulator
HS_RS04115	COG4166	transmembrane transport
HS_RS04120	COG0488	(ABC) transporter
HS_RS04130	COG0814	amino acid
HS_RS04135	COG3033	Beta-eliminating lyase
HS_RS04140	COG0280	phosphate acetyltransferase
HS_RS04140	COG0857	belongs to the CobB CobQ family
HS_RS04145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HS_RS04160	COG0243	molybdopterin cofactor binding
HS_RS04165	COG3005	denitrification pathway
HS_RS04175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS_RS04180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HS_RS04190	COG0307	riboflavin synthase, alpha
HS_RS04195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HS_RS04200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HS_RS04205	COG3105	Protein conserved in bacteria
HS_RS04210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS_RS04215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HS_RS04220	COG0515	serine threonine protein kinase
HS_RS04230	COG0779	Required for maturation of 30S ribosomal subunits
HS_RS04235	COG0195	Participates in both transcription termination and antitermination
HS_RS04255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HS_RS04260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HS_RS04265	COG3112	Uncharacterised protein family (UPF0231)
HS_RS04270	COG0316	Belongs to the HesB IscA family
HS_RS04275	COG0024	Methionine aminopeptidase
HS_RS04290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HS_RS04295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HS_RS04300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HS_RS04305	COG1280	lysine exporter protein (LysE YggA)
HS_RS04310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HS_RS04315	COG0708	Exodeoxyribonuclease III
HS_RS04320	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HS_RS04325	COG1448	Aminotransferase
HS_RS04330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HS_RS04335	COG0288	reversible hydration of carbon dioxide
HS_RS04340	COG0616	signal peptide processing
HS_RS04355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS_RS04360	COG3118	belongs to the thioredoxin family
HS_RS04365	COG2252	PERMEase
HS_RS04370	COG3101	peptidyl-lysine hydroxylation
HS_RS04375	COG1131	(ABC) transporter
HS_RS04380	COG0842	Transport permease protein
HS_RS04385	COG1611	Belongs to the LOG family
HS_RS04390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HS_RS04390	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HS_RS04395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HS_RS04400	COG3098	single-species biofilm formation
HS_RS04410	COG1278	Cold shock
HS_RS04420	COG1067	ATP-dependent peptidase activity
HS_RS04425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HS_RS04445	COG0037	tRNA processing
HS_RS04450	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HS_RS04455	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HS_RS04465	COG0697	spore germination
HS_RS04490	COG2925	Exonuclease
HS_RS04500	COG0586	Pfam SNARE associated Golgi protein
HS_RS04520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HS_RS04525	COG0589	response to stress
HS_RS04530	COG0285	dihydrofolate synthase activity
HS_RS04540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS_RS04545	COG0613	PHP domain protein
HS_RS04550	COG0308	aminopeptidase N
HS_RS04560	COG0297	glycogen (starch) synthase activity
HS_RS04570	COG1523	belongs to the glycosyl hydrolase 13 family
HS_RS04575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HS_RS04580	COG1640	4-alpha-glucanotransferase
HS_RS04590	COG0612	Peptidase, M16
HS_RS04635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS_RS04635	COG0301	tRNA thio-modification
HS_RS04640	COG1722	exodeoxyribonuclease VII activity
HS_RS04645	COG0142	geranyltranstransferase activity
HS_RS04650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HS_RS04655	COG2431	L-lysine efflux transmembrane transporter activity
HS_RS04660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HS_RS04665	COG0616	signal peptide processing
HS_RS04670	COG0778	Nitroreductase
HS_RS04680	COG0303	'Molybdopterin
HS_RS04685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HS_RS04690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HS_RS04695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HS_RS04700	COG0163	prenyltransferase activity
HS_RS04710	COG1286	toxin biosynthetic process
HS_RS04715	COG0517	IMP dehydrogenase activity
HS_RS04715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS_RS04720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HS_RS04725	COG1528	Iron-storage protein
HS_RS04730	COG1528	Iron-storage protein
HS_RS04735	COG1349	DNA-binding transcription factor activity
HS_RS04740	COG3395	kinase activity
HS_RS04750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HS_RS04755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HS_RS04760	COG0076	glutamate decarboxylase activity
HS_RS04765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HS_RS04770	COG1074	ATP-dependent DNA helicase activity
HS_RS04780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HS_RS04785	COG0825	malonyl-CoA metabolic process
HS_RS04795	COG0037	tRNA processing
HS_RS04805	COG4735	regulation of single-species biofilm formation
HS_RS04810	COG4735	regulation of single-species biofilm formation
HS_RS04815	COG0166	Belongs to the GPI family
HS_RS04825	COG0305	Participates in initiation and elongation during chromosome replication
HS_RS04830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HS_RS04835	COG4591	ABC-type transport system involved in lipoprotein release permease component
HS_RS04840	COG1136	(ABC) transporter
HS_RS04845	COG4591	ABC-type transport system involved in lipoprotein release permease component
HS_RS04850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS_RS04855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HS_RS04870	COG1714	RDD family
HS_RS04875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HS_RS04880	COG3133	Outer membrane lipoprotein
HS_RS04890	COG3102	Protein conserved in bacteria
HS_RS04895	COG0018	arginyl-trna synthetase
HS_RS04900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HS_RS04905	COG0045	succinate-CoA ligase (ADP-forming) activity
HS_RS04910	COG0508	dehydrogenase complex catalyzes the overall conversion of
HS_RS04915	COG0567	Dehydrogenase, E1 component
HS_RS04925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HS_RS04930	COG0633	Ferredoxin
HS_RS04935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HS_RS04940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HS_RS04950	COG1525	nuclease
HS_RS04960	COG2166	iron-sulfur cluster assembly
HS_RS04965	COG3077	Addiction module antitoxin, RelB DinJ family
HS_RS04970	COG3041	Addiction module toxin RelE StbE family
HS_RS04980	COG0023	Translation Initiation Factor
HS_RS04985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HS_RS04990	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HS_RS05000	COG0539	negative regulation of cytoplasmic translation
HS_RS05005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HS_RS05010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS_RS05025	COG0750	zinc metalloprotease
HS_RS05030	COG0575	Belongs to the CDS family
HS_RS05040	COG5413	integral membrane protein
HS_RS05045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HS_RS05055	COG0528	UMP kinase activity
HS_RS05070	COG0653	protein targeting
HS_RS05075	COG0494	nUDIX hydrolase
HS_RS05080	COG1643	Atp-dependent helicase
HS_RS05085	COG2707	UPF0756 membrane protein
HS_RS05090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HS_RS05095	COG3099	Belongs to the UPF0263 family
HS_RS05105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HS_RS05110	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HS_RS05125	COG1534	Rna-binding protein
HS_RS05130	COG1393	Belongs to the ArsC family
HS_RS05140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HS_RS05145	COG0531	amino acid
HS_RS05160	COG0583	DNA-binding transcription factor activity
HS_RS05165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HS_RS05170	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HS_RS05175	COG1178	ABC-type Fe3 transport system permease component
HS_RS05180	COG4143	(ABC) transporter
HS_RS05185	COG2056	Na+-H+ antiporter family
HS_RS05195	COG1595	DNA-templated transcription, initiation
HS_RS05200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS_RS05235	COG0116	Belongs to the methyltransferase superfamily
HS_RS05235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HS_RS05240	COG1132	(ABC) transporter
HS_RS05245	COG0658	competence protein
HS_RS05245	COG2333	competence protein COMEC
HS_RS05250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HS_RS05255	COG0617	tRNA 3'-terminal CCA addition
HS_RS05260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HS_RS05265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HS_RS05270	COG0363	glucosamine-6-phosphate deaminase activity
HS_RS05275	COG0314	molybdopterin synthase activity
HS_RS05280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HS_RS05285	COG0315	cyclic pyranopterin monophosphate synthase activity
HS_RS05290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS_RS05295	COG1609	Transcriptional regulator
HS_RS05300	COG0583	DNA-binding transcription factor activity
HS_RS05315	COG0739	heme binding
HS_RS05320	COG1121	(ABC) transporter
HS_RS05325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS_RS05330	COG1115	amino acid carrier protein
HS_RS05335	COG1940	carbohydrate kinase activity
HS_RS05340	COG0671	phosphoesterase, PA-phosphatase related
HS_RS05350	COG0247	lactate metabolic process
HS_RS05350	COG0277	FAD linked oxidase domain protein
HS_RS05365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HS_RS05370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS_RS05375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS_RS05375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS_RS05385	COG1687	branched-chain amino acid
HS_RS05390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HS_RS05395	COG0583	DNA-binding transcription factor activity
HS_RS05400	COG0039	L-malate dehydrogenase activity
HS_RS05405	COG1438	arginine binding
HS_RS05410	COG1090	epimerase
HS_RS05415	COG5295	Hep Hag repeat protein
HS_RS05415	COG5295	Hep Hag repeat protein
HS_RS05420	COG4657	Part of a membrane complex involved in electron transport
HS_RS05430	COG4656	Part of a membrane complex involved in electron transport
HS_RS05435	COG4658	electron transport chain
HS_RS05450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HS_RS05455	COG0733	neurotransmitter:sodium symporter activity
HS_RS05465	COG3008	intermembrane lipid transfer
HS_RS05470	COG2995	paraquat-inducible protein a
HS_RS05475	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HS_RS05480	COG0793	Belongs to the peptidase S41A family
HS_RS05485	COG2989	Protein conserved in bacteria
HS_RS05490	COG3108	Peptidase M15
HS_RS05495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS_RS05500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HS_RS05510	COG2949	membrane
HS_RS05525	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HS_RS05530	COG3683	transport system, periplasmic component
HS_RS05535	COG0802	atpase or kinase
HS_RS05540	COG1388	LysM domain
HS_RS05540	COG0860	N-Acetylmuramoyl-L-alanine amidase
HS_RS05545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HS_RS05550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HS_RS05560	COG0469	pyruvate kinase activity
HS_RS05565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HS_RS05580	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HS_RS05590	COG2932	Transcriptional regulator
HS_RS05595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS_RS05600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HS_RS05605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HS_RS05610	COG2190	(PTS) system
HS_RS05615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS_RS05620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS_RS05625	COG1162	GTPase activity
HS_RS05640	COG0004	ammonium transporteR
HS_RS05650	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HS_RS05655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HS_RS05660	COG1923	regulation of RNA biosynthetic process
HS_RS05665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS_RS05670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HS_RS05675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HS_RS05680	COG4972	Pilus assembly protein
HS_RS05695	COG4796	Type ii and iii secretion system protein
HS_RS05705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HS_RS05710	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HS_RS05715	COG3676	manually curated
HS_RS05720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HS_RS05725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HS_RS05745	COG3956	TIGRFAM MazG family protein
HS_RS05750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HS_RS05755	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HS_RS05760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HS_RS05765	COG1792	Involved in formation and maintenance of cell shape
HS_RS05770	COG1077	Cell shape determining protein MreB Mrl
HS_RS05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HS_RS05795	COG1472	Belongs to the glycosyl hydrolase 3 family
HS_RS05805	COG0537	adenosine 5'-monophosphoramidase activity
HS_RS05810	COG2116	formate transmembrane transporter activity
HS_RS05815	COG1882	Formate acetyltransferase
HS_RS05820	COG2259	Doxx family
HS_RS05830	COG3220	belongs to the UPF0276 family
HS_RS05835	COG3219	Protein conserved in bacteria
HS_RS05840	COG1349	DNA-binding transcription factor activity
HS_RS05845	COG1063	alcohol dehydrogenase
HS_RS05850	COG3775	system Galactitol-specific IIC component
HS_RS05855	COG3414	Phosphotransferase system galactitol-specific IIB component
HS_RS05860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS_RS05870	COG3684	Belongs to the aldolase LacD family
HS_RS05875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HS_RS05880	COG0492	ferredoxin-NADP+ reductase activity
HS_RS05885	COG4988	ABC transporter
HS_RS05890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HS_RS05895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HS_RS05900	COG2833	Protein of unknown function (DUF455)
HS_RS05905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HS_RS05910	COG5295	Hep Hag repeat protein
HS_RS05920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS_RS05925	COG3842	ATPase activity
HS_RS05930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HS_RS05935	COG1177	transmembrane transport
HS_RS05940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HS_RS05945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HS_RS05950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS_RS05955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HS_RS05960	COG2824	Alkylphosphonate utilization operon protein PhnA
HS_RS05965	COG0814	amino acid
HS_RS05970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HS_RS05975	COG5007	Belongs to the BolA IbaG family
HS_RS05980	COG3113	response to antibiotic
HS_RS05985	COG2854	intermembrane phospholipid transfer
HS_RS05990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HS_RS05995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HS_RS06000	COG1127	ABC transporter
HS_RS06005	COG3117	lipopolysaccharide transmembrane transporter activity
HS_RS06010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HS_RS06015	COG1137	ATPase activity
HS_RS06020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS_RS06030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS_RS06030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS_RS06035	COG0489	protein tyrosine kinase activity
HS_RS06040	COG4149	molybdate abc transporter
HS_RS06045	COG0725	ABC transporter, periplasmic molybdate-binding protein
HS_RS06070	COG1522	sequence-specific DNA binding
HS_RS06075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HS_RS06080	COG3025	triphosphatase activity
HS_RS06085	COG1392	Phosphate transport regulator
HS_RS06090	COG0306	phosphate transporter
HS_RS06095	COG4991	sh3 domain protein
HS_RS06100	COG0617	tRNA 3'-terminal CCA addition
HS_RS06105	COG0443	Heat shock 70 kDa protein
HS_RS06110	COG0484	heat shock protein binding
HS_RS06115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HS_RS06130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HS_RS06140	COG1560	Kdo2-lipid A biosynthetic process
HS_RS06145	COG0730	response to heat
HS_RS06150	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HS_RS06160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HS_RS06160	COG3264	Mechanosensitive ion channel
HS_RS06165	COG0318	PFAM AMP-dependent synthetase and ligase
HS_RS06170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HS_RS06175	COG0596	Alpha beta hydrolase
HS_RS06180	COG0716	FMN binding
HS_RS06185	COG0735	belongs to the Fur family
HS_RS06190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HS_RS06195	COG0083	homoserine kinase activity
HS_RS06200	COG0460	homoserine dehydrogenase
HS_RS06200	COG0527	aspartate kinase activity
HS_RS06210	COG1570	exodeoxyribonuclease VII activity
HS_RS06220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HS_RS06245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HS_RS06250	COG4106	trans-aconitate 2-methyltransferase activity
HS_RS06255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HS_RS06265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS_RS06325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS_RS06335	COG4545	Glutaredoxin-related protein
HS_RS06345	COG2095	MarC family integral membrane protein
HS_RS06350	COG5295	Hep Hag repeat protein
HS_RS06355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HS_RS06385	COG0681	Belongs to the peptidase S26 family
HS_RS06395	COG1473	amidohydrolase
HS_RS06400	COG3069	C4-dicarboxylate transmembrane transporter activity
HS_RS06425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HS_RS06430	COG3722	fumarate hydratase activity
HS_RS06435	COG0246	Mannitol dehydrogenase
HS_RS06445	COG1940	carbohydrate kinase activity
HS_RS06450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HS_RS06455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HS_RS06460	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HS_RS06465	COG0295	cytidine deaminase activity
HS_RS06470	COG0101	tRNA pseudouridine synthase activity
HS_RS06490	COG3177	Filamentation induced by cAMP protein fic
HS_RS06500	COG2927	DNA polymerase III (CHI subunit)
HS_RS06520	COG1607	acyl-coa hydrolase
HS_RS06525	COG2350	Protein conserved in bacteria
HS_RS06545	COG0444	Belongs to the ABC transporter superfamily
HS_RS06550	COG4608	Belongs to the ABC transporter superfamily
HS_RS06555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HS_RS06565	COG1053	succinate dehydrogenase
HS_RS06570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HS_RS06595	COG4974	Belongs to the 'phage' integrase family
HS_RS06600	COG2814	Major facilitator Superfamily
HS_RS06605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HS_RS06615	COG3061	Opacity-associated protein A
HS_RS06615	COG3266	domain, Protein
HS_RS06620	COG1509	lysine 2,3-aminomutase activity
HS_RS06640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS_RS06645	COG1561	YicC-like family, N-terminal region
HS_RS06650	COG0354	folic acid binding
HS_RS06655	COG0513	Belongs to the DEAD box helicase family
HS_RS06660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HS_RS06665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HS_RS06670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HS_RS06680	COG0688	phosphatidylethanolamine metabolic process
HS_RS06685	COG0545	Peptidyl-prolyl cis-trans isomerase
HS_RS06690	COG0488	(ABC) transporter
HS_RS06695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HS_RS06705	COG0442	prolyl-tRNA aminoacylation
HS_RS06720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HS_RS06735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HS_RS06745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HS_RS06750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HS_RS06755	COG1862	Preprotein translocase
HS_RS06760	COG0343	queuine tRNA-ribosyltransferase activity
HS_RS06770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HS_RS06775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HS_RS06780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HS_RS06805	COG0826	peptidase U32
HS_RS06810	COG1793	dna ligase
HS_RS06820	COG3028	Belongs to the UPF0307 family
HS_RS06825	COG0312	modulator of DNA gyrase
HS_RS06830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HS_RS06840	COG3250	beta-galactosidase activity
HS_RS06875	COG0582	viral genome integration into host DNA
HS_RS06885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HS_RS06890	COG0121	glutamine amidotransferase
HS_RS06905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HS_RS06915	COG0626	cystathionine gamma-synthase activity
HS_RS06950	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HS_RS06955	COG1803	Methylglyoxal synthase
HS_RS06960	COG1289	transmembrane transporter activity
HS_RS06970	COG2890	protein-(glutamine-N5) methyltransferase activity
HS_RS06975	COG0628	permease
HS_RS06985	COG0521	Mo-molybdopterin cofactor biosynthetic process
HS_RS06990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HS_RS06995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS_RS07000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS_RS07010	COG2990	Protein conserved in bacteria
HS_RS07015	COG0137	argininosuccinate synthase activity
HS_RS07020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS_RS07160	COG0675	Transposase, IS605 OrfB family
HS_RS07190	COG1598	PFAM Uncharacterised protein family UPF0150
HS_RS07200	COG3617	BRO family, N-terminal domain
HS_RS07310	COG3723	Recombinational DNA repair protein, rece pathway
HS_RS07330	COG0202	RNA polymerase activity
HS_RS07340	COG0582	viral genome integration into host DNA
HS_RS07350	COG0659	secondary active sulfate transmembrane transporter activity
HS_RS07355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HS_RS07360	COG4137	Cytochrome C assembly protein
HS_RS07365	COG4536	flavin adenine dinucleotide binding
HS_RS07370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HS_RS07385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HS_RS07390	COG1473	amidohydrolase
HS_RS07400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HS_RS07405	COG2965	DNA replication, synthesis of RNA primer
HS_RS07410	COG0360	Binds together with S18 to 16S ribosomal RNA
HS_RS07415	COG1285	pathogenesis
HS_RS07425	COG1522	sequence-specific DNA binding
HS_RS07430	COG2861	carbohydrate metabolic process
HS_RS07435	COG4942	peptidase
HS_RS07440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS_RS07450	COG1349	DNA-binding transcription factor activity
HS_RS07455	COG0738	Major facilitator superfamily
HS_RS07460	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HS_RS07465	COG1070	Carbohydrate kinase
HS_RS07470	COG4154	Belongs to the RbsD FucU family
HS_RS07475	COG0235	Class ii aldolase
HS_RS07510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HS_RS07515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS_RS07520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HS_RS07530	COG0194	GDP metabolic process
HS_RS07535	COG3475	LICD family
HS_RS07540	COG4750	Nucleotidyl transferase
HS_RS07545	COG0697	spore germination
HS_RS07555	COG3676	manually curated
HS_RS07570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HS_RS07575	COG0602	queuosine metabolic process
HS_RS07580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HS_RS07580	COG1328	CTP reductase activity
HS_RS07585	COG4178	(ABC) transporter
HS_RS07590	COG2985	domain, Protein
HS_RS07600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HS_RS07605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HS_RS07610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS_RS07630	COG2814	Major facilitator Superfamily
HS_RS07635	COG1584	GPR1 FUN34 yaaH family protein
HS_RS07650	COG1253	flavin adenine dinucleotide binding
HS_RS07660	COG0084	hydrolase, TatD family'
HS_RS07665	COG0470	DNA polymerase III
HS_RS07670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS_RS07675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HS_RS07685	COG1040	competence protein
HS_RS07695	COG1114	Component of the transport system for branched-chain amino acids
HS_RS07700	COG2183	response to ionizing radiation
HS_RS07715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HS_RS07720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HS_RS07720	COG0475	glutathione-regulated potassium exporter activity
HS_RS07725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HS_RS07730	COG0585	pseudouridine synthase activity
HS_RS07750	COG0047	phosphoribosylformylglycinamidine synthase activity
HS_RS07750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HS_RS07755	COG3005	denitrification pathway
HS_RS07760	COG3043	anaerobic respiration
HS_RS07765	COG0348	domain, Protein
HS_RS07770	COG0437	4 iron, 4 sulfur cluster binding
HS_RS07775	COG0243	molybdopterin cofactor binding
HS_RS07780	COG3062	negative regulation of establishment of protein localization
HS_RS07785	COG3850	Histidine kinase
HS_RS07810	COG0564	pseudouridine synthase activity
HS_RS07815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HS_RS07830	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HS_RS07855	COG3835	regulator
HS_RS07865	COG1929	Belongs to the glycerate kinase type-1 family
HS_RS07905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HS_RS07920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HS_RS07925	COG1349	DNA-binding transcription factor activity
HS_RS07935	COG3068	Protein conserved in bacteria
HS_RS07940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HS_RS07950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HS_RS07965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HS_RS07970	COG1741	Belongs to the pirin family
HS_RS07975	COG3691	Protein conserved in bacteria
HS_RS07985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HS_RS07990	COG3066	DNA modification
HS_RS07995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HS_RS08000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS_RS08005	COG2177	Part of the ABC transporter FtsEX involved in
HS_RS08010	COG2884	Cell division ATP-binding protein ftsE
HS_RS08015	COG1466	dna polymerase III delta subunit
HS_RS08020	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HS_RS08025	COG0495	leucyl-tRNA aminoacylation
HS_RS08030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HS_RS08040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HS_RS08045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HS_RS08050	COG0814	amino acid
HS_RS08060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS_RS08065	COG0085	RNA polymerase activity
HS_RS08070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HS_RS08125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HS_RS08130	COG1739	Uncharacterized protein family UPF0029
HS_RS08135	COG0425	Belongs to the sulfur carrier protein TusA family
HS_RS08140	COG1982	Orn Lys Arg decarboxylase major
HS_RS08145	COG0531	amino acid
HS_RS08150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HS_RS08155	COG0673	inositol 2-dehydrogenase activity
HS_RS08170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS_RS08175	COG1129	ABC transporter
HS_RS08180	COG1879	ABC-type sugar transport system periplasmic component
HS_RS08185	COG1879	ABC-type sugar transport system periplasmic component
HS_RS08190	COG0673	inositol 2-dehydrogenase activity
HS_RS08200	COG0823	Involved in the tonB-independent uptake of proteins
HS_RS08210	COG3718	enzyme involved in inositol metabolism
HS_RS08215	COG1132	(ABC) transporter
HS_RS08220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HS_RS08225	COG1519	Transferase
HS_RS08230	COG0149	triose-phosphate isomerase activity
HS_RS08235	COG0456	acetyltransferase
HS_RS08240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HS_RS08255	COG1312	Catalyzes the dehydration of D-mannonate
HS_RS08260	COG2186	Transcriptional regulator
HS_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
HS_RS08280	COG2211	Major facilitator Superfamily
HS_RS08290	COG0800	Aldolase
HS_RS08300	COG1595	DNA-templated transcription, initiation
HS_RS08305	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HS_RS08310	COG3026	antisigma factor binding
HS_RS08315	COG3086	response to oxidative stress
HS_RS08320	COG1763	Mo-molybdopterin cofactor biosynthetic process
HS_RS08325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HS_RS08335	COG0859	PFAM glycosyl transferase family 9
HS_RS08365	COG0590	tRNA wobble adenosine to inosine editing
HS_RS08380	COG0730	response to heat
HS_RS08395	COG3091	SprT-like family
HS_RS08400	COG0138	bifunctional purine biosynthesis protein purh
HS_RS08410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HS_RS08420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HS_RS08425	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HS_RS08450	COG2923	Belongs to the DsrF TusC family
HS_RS08460	COG2964	Protein conserved in bacteria
HS_RS08465	COG0545	Peptidyl-prolyl cis-trans isomerase
HS_RS08470	COG2900	Belongs to the SlyX family
HS_RS08480	COG1187	pseudouridine synthase activity
HS_RS08490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HS_RS08520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HS_RS08525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HS_RS08530	COG1218	3'(2'),5'-bisphosphate nucleotidase
HS_RS08535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HS_RS08540	COG0363	glucosamine-6-phosphate deaminase activity
HS_RS08550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HS_RS08555	COG2853	Lipoprotein
HS_RS08570	COG0762	integral membrane protein
HS_RS08580	COG3171	Protein conserved in bacteria
HS_RS08585	COG0583	DNA-binding transcription factor activity
HS_RS08590	COG0471	metal ion transport
HS_RS08605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HS_RS08610	COG1194	a g-specific adenine glycosylase
HS_RS08625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS_RS08630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HS_RS08635	COG3005	denitrification pathway
HS_RS08645	COG3381	protein complex oligomerization
HS_RS08665	COG3676	manually curated
HS_RS08680	COG0482	sulfurtransferase activity
HS_RS08690	COG2991	Protein conserved in bacteria
HS_RS08695	COG1477	protein flavinylation
HS_RS08705	COG2871	sodium ion transport
HS_RS08710	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS_RS08715	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS_RS08730	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS_RS08735	COG0271	Belongs to the BolA IbaG family
HS_RS08740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HS_RS08745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HS_RS08750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HS_RS08760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HS_RS08775	COG0356	it plays a direct role in the translocation of protons across the membrane
HS_RS08780	COG3312	ion transport
HS_RS08785	COG0357	Ribosomal RNA small subunit methyltransferase G
HS_RS08790	COG0445	tRNA wobble uridine modification
HS_RS08795	COG0716	FMN binding
HS_RS08805	COG0187	DNA topoisomerase II activity
HS_RS08810	COG3676	manually curated
HS_RS08825	COG1965	Belongs to the frataxin family
HS_RS08830	COG0019	diaminopimelate decarboxylase activity
HS_RS08835	COG0733	neurotransmitter:sodium symporter activity
HS_RS08845	COG3070	regulator of competence-specific genes
HS_RS08875	COG0583	DNA-binding transcription factor activity
HS_RS08880	COG2610	gluconate transmembrane transporter activity
HS_RS08885	COG3048	D-serine ammonia-lyase activity
HS_RS08950	COG0629	single-stranded DNA binding
HS_RS09235	COG4453	Protein conserved in bacteria
HS_RS09310	COG1442	glycosyl transferase family 8
HS_RS09315	COG1629	transport
HS_RS09315	COG4771	TonB-dependent receptor