locus-tag	class	description
HALSA_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HALSA_RS00015	COG0592	DNA-directed DNA polymerase activity
HALSA_RS00020	COG2501	S4 domain
HALSA_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HALSA_RS00035	COG0187	DNA topoisomerase II activity
HALSA_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HALSA_RS00080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HALSA_RS00090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALSA_RS00100	COG0693	protein deglycase activity
HALSA_RS00105	COG2376	Dihydroxyacetone kinase
HALSA_RS00115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HALSA_RS00130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS00130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HALSA_RS00130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HALSA_RS00140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HALSA_RS00145	COG3875	lactate racemase activity
HALSA_RS00150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HALSA_RS00155	COG0800	Aldolase
HALSA_RS00165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HALSA_RS00170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HALSA_RS00170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HALSA_RS00180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HALSA_RS00195	COG4974	Belongs to the 'phage' integrase family
HALSA_RS00220	COG0582	viral genome integration into host DNA
HALSA_RS00225	COG1132	(ABC) transporter
HALSA_RS00235	COG0028	Belongs to the TPP enzyme family
HALSA_RS00235	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HALSA_RS00245	COG1454	alcohol dehydrogenase
HALSA_RS00270	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS00295	COG2801	Transposase and inactivated derivatives
HALSA_RS00325	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS00335	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS00360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HALSA_RS00365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HALSA_RS00385	COG0358	DNA primase activity
HALSA_RS00400	COG3339	Conserved Protein
HALSA_RS00430	COG2003	Belongs to the UPF0758 family
HALSA_RS00455	COG3328	transposase activity
HALSA_RS00460	COG0641	radical SAM
HALSA_RS00485	COG3119	arylsulfatase activity
HALSA_RS00490	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HALSA_RS00495	COG1846	Transcriptional regulator
HALSA_RS00495	COG1940	carbohydrate kinase activity
HALSA_RS00500	COG0667	Aldo Keto reductase
HALSA_RS00505	COG0656	L-ascorbic acid biosynthetic process
HALSA_RS00520	COG3022	response to hydroperoxide
HALSA_RS00530	COG3328	transposase activity
HALSA_RS00535	COG0840	transmembrane signaling receptor activity
HALSA_RS00535	COG3290	protein histidine kinase activity
HALSA_RS00560	COG0484	heat shock protein binding
HALSA_RS00570	COG0534	Mate efflux family protein
HALSA_RS00575	COG2131	deaminase
HALSA_RS00610	COG1940	carbohydrate kinase activity
HALSA_RS00615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HALSA_RS00620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HALSA_RS00625	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HALSA_RS00645	COG0395	ABC-type sugar transport system, permease component
HALSA_RS00650	COG3250	beta-galactosidase activity
HALSA_RS00655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS00655	COG2199	diguanylate cyclase activity
HALSA_RS00665	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HALSA_RS00675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HALSA_RS00690	COG2610	gluconate transmembrane transporter activity
HALSA_RS00695	COG2045	Belongs to the ComB family
HALSA_RS00700	COG3711	transcriptional antiterminator
HALSA_RS00700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS00710	COG3414	Phosphotransferase system galactitol-specific IIB component
HALSA_RS00715	COG3775	system Galactitol-specific IIC component
HALSA_RS00720	COG0347	Belongs to the P(II) protein family
HALSA_RS00725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HALSA_RS00725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HALSA_RS00730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS00745	COG1447	Phosphotransferase system cellobiose-specific component IIA
HALSA_RS00750	COG1486	melibiose metabolic process
HALSA_RS00755	COG2723	6-phospho-beta-galactosidase activity
HALSA_RS00770	COG3711	transcriptional antiterminator
HALSA_RS00775	COG1263	PTS System
HALSA_RS00775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HALSA_RS00775	COG2190	(PTS) system
HALSA_RS00780	COG2190	(PTS) system
HALSA_RS00785	COG0363	glucosamine-6-phosphate deaminase activity
HALSA_RS00815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS00820	COG1802	Transcriptional regulator
HALSA_RS00825	COG1802	Transcriptional regulator
HALSA_RS00830	COG1129	ABC transporter
HALSA_RS00835	COG1172	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS00840	COG1879	ABC-type sugar transport system periplasmic component
HALSA_RS00850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALSA_RS00855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HALSA_RS00855	COG0022	dehydrogenase e1 component
HALSA_RS00865	COG1172	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS00870	COG1172	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS00875	COG1879	ABC-type sugar transport system periplasmic component
HALSA_RS00880	COG1129	ABC transporter
HALSA_RS00885	COG0673	inositol 2-dehydrogenase activity
HALSA_RS00890	COG1082	Xylose isomerase domain protein TIM barrel
HALSA_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS00905	COG1012	belongs to the aldehyde dehydrogenase family
HALSA_RS00910	COG0045	succinate-CoA ligase (ADP-forming) activity
HALSA_RS00915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HALSA_RS00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALSA_RS00925	COG0281	malic enzyme
HALSA_RS00930	COG0281	malic enzyme
HALSA_RS00940	COG3875	lactate racemase activity
HALSA_RS00945	COG0574	Belongs to the PEP-utilizing enzyme family
HALSA_RS00945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HALSA_RS00955	COG0589	response to stress
HALSA_RS00960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HALSA_RS00975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS00995	COG0840	transmembrane signaling receptor activity
HALSA_RS01030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HALSA_RS01035	COG3706	GGDEF domain
HALSA_RS01050	COG0174	glutamine synthetase
HALSA_RS01055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HALSA_RS01065	COG0069	glutamate synthase activity
HALSA_RS01085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALSA_RS01090	COG0251	oxidation-reduction process
HALSA_RS01105	COG0537	adenosine 5'-monophosphoramidase activity
HALSA_RS01145	COG2801	Transposase and inactivated derivatives
HALSA_RS01150	COG0433	COG0433 Predicted ATPase
HALSA_RS01235	COG3012	SEC-C Motif Domain Protein
HALSA_RS01270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HALSA_RS01285	COG0730	response to heat
HALSA_RS01290	COG1132	(ABC) transporter
HALSA_RS01295	COG1132	(ABC) transporter
HALSA_RS01300	COG0640	Transcriptional regulator
HALSA_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS01335	COG2201	protein-glutamate methylesterase activity
HALSA_RS01355	COG0406	alpha-ribazole phosphatase activity
HALSA_RS01360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HALSA_RS01370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HALSA_RS01375	COG1063	alcohol dehydrogenase
HALSA_RS01380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALSA_RS01400	COG1074	ATP-dependent DNA helicase activity
HALSA_RS01405	COG3443	Belongs to the bacterial solute-binding protein 9 family
HALSA_RS01405	COG0803	Belongs to the bacterial solute-binding protein 9 family
HALSA_RS01410	COG1121	(ABC) transporter
HALSA_RS01415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HALSA_RS01440	COG0490	domain, Protein
HALSA_RS01445	COG0475	glutathione-regulated potassium exporter activity
HALSA_RS01460	COG0011	TIGRFAM Protein of
HALSA_RS01490	COG1136	(ABC) transporter
HALSA_RS01490	COG0577	efflux transmembrane transporter activity
HALSA_RS01495	COG4591	ABC-type transport system involved in lipoprotein release permease component
HALSA_RS01525	COG0778	Nitroreductase
HALSA_RS01530	COG2508	Transcriptional regulator
HALSA_RS01550	COG0601	transmembrane transport
HALSA_RS01555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS01560	COG0444	Belongs to the ABC transporter superfamily
HALSA_RS01565	COG4608	Belongs to the ABC transporter superfamily
HALSA_RS01570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HALSA_RS01580	COG0205	6-phosphofructokinase activity
HALSA_RS01585	COG3588	fructose-bisphosphate aldolase
HALSA_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS01605	COG3588	fructose-bisphosphate aldolase
HALSA_RS01615	COG3835	regulator
HALSA_RS01630	COG1473	amidohydrolase
HALSA_RS01635	COG1473	amidohydrolase
HALSA_RS01640	COG2094	Belongs to the DNA glycosylase MPG family
HALSA_RS01680	COG2199	diguanylate cyclase activity
HALSA_RS01685	COG0501	Belongs to the peptidase M48B family
HALSA_RS01695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HALSA_RS01710	COG0590	tRNA wobble adenosine to inosine editing
HALSA_RS01725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HALSA_RS01730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HALSA_RS01735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HALSA_RS01740	COG0517	IMP dehydrogenase activity
HALSA_RS01740	COG0516	GMP reductase activity
HALSA_RS01745	COG0492	ferredoxin-NADP+ reductase activity
HALSA_RS01750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HALSA_RS01755	COG3870	Protein conserved in bacteria
HALSA_RS01760	COG0470	DNA polymerase III
HALSA_RS01765	COG1774	PSP1 C-terminal conserved region
HALSA_RS01775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HALSA_RS01780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HALSA_RS01785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALSA_RS01785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALSA_RS01790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HALSA_RS01795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HALSA_RS01800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HALSA_RS01805	COG0686	Belongs to the AlaDH PNT family
HALSA_RS01810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HALSA_RS01830	COG1827	regulation of RNA biosynthetic process
HALSA_RS01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HALSA_RS01845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HALSA_RS01850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HALSA_RS01860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HALSA_RS01870	COG0077	Prephenate dehydratase
HALSA_RS01875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HALSA_RS01880	COG0287	Prephenate dehydrogenase
HALSA_RS01885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HALSA_RS01890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALSA_RS01895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HALSA_RS01900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HALSA_RS01905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HALSA_RS01910	COG0745	RESPONSE REGULATOR receiver
HALSA_RS01915	COG5002	protein histidine kinase activity
HALSA_RS01920	COG1362	aminopeptidase activity
HALSA_RS01930	COG3118	belongs to the thioredoxin family
HALSA_RS01945	COG0018	arginyl-trna synthetase
HALSA_RS01955	COG1024	Enoyl-CoA hydratase
HALSA_RS01970	COG0530	calcium, potassium:sodium antiporter activity
HALSA_RS01975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HALSA_RS01980	COG0254	rRNA binding
HALSA_RS01985	COG1435	thymidine kinase activity
HALSA_RS01990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HALSA_RS01995	COG2890	protein-(glutamine-N5) methyltransferase activity
HALSA_RS02000	COG0009	L-threonylcarbamoyladenylate synthase
HALSA_RS02005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HALSA_RS02010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HALSA_RS02015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HALSA_RS02025	COG0356	it plays a direct role in the translocation of protons across the membrane
HALSA_RS02030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HALSA_RS02045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HALSA_RS02050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HALSA_RS02055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HALSA_RS02060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HALSA_RS02065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HALSA_RS02070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HALSA_RS02080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HALSA_RS02115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HALSA_RS02135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HALSA_RS02145	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HALSA_RS02155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HALSA_RS02165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HALSA_RS02180	COG1137	ATPase activity
HALSA_RS02185	COG0795	lipopolysaccharide-transporting ATPase activity
HALSA_RS02190	COG4372	Transposase
HALSA_RS02220	COG3206	protein involved in exopolysaccharide biosynthesis
HALSA_RS02225	COG1794	racemase activity, acting on amino acids and derivatives
HALSA_RS02230	COG0346	lactoylglutathione lyase activity
HALSA_RS02235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALSA_RS02240	COG0497	DNA recombination
HALSA_RS02265	COG1196	nuclear chromosome segregation
HALSA_RS02270	COG0785	Cytochrome C biogenesis protein
HALSA_RS02280	COG0785	Cytochrome C biogenesis protein
HALSA_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALSA_RS02310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HALSA_RS02330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HALSA_RS02330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HALSA_RS02335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HALSA_RS02335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HALSA_RS02375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HALSA_RS02390	COG1757	Na H antiporter
HALSA_RS02405	COG0653	protein targeting
HALSA_RS02410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HALSA_RS02425	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HALSA_RS02430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HALSA_RS02435	COG0793	Belongs to the peptidase S41A family
HALSA_RS02440	COG1760	l-serine dehydratase
HALSA_RS02445	COG1760	l-serine dehydratase
HALSA_RS02455	COG0556	nucleotide-excision repair
HALSA_RS02470	COG0601	transmembrane transport
HALSA_RS02475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS02485	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HALSA_RS02490	COG0584	glycerophosphoryl diester phosphodiesterase
HALSA_RS02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HALSA_RS02500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HALSA_RS02505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HALSA_RS02510	COG1285	pathogenesis
HALSA_RS02515	COG0584	glycerophosphoryl diester phosphodiesterase
HALSA_RS02540	COG0322	excinuclease ABC activity
HALSA_RS02545	COG3634	alkyl hydroperoxide reductase activity
HALSA_RS02555	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HALSA_RS02560	COG1802	Transcriptional regulator
HALSA_RS02595	COG1929	Belongs to the glycerate kinase type-1 family
HALSA_RS02600	COG0070	glutamate synthase
HALSA_RS02600	COG0069	glutamate synthase activity
HALSA_RS02600	COG0067	glutamate synthase
HALSA_RS02605	COG0493	'glutamate synthase
HALSA_RS02625	COG0765	amino acid transport
HALSA_RS02630	COG0277	FAD linked oxidase domain protein
HALSA_RS02635	COG2223	nitrite transmembrane transporter activity
HALSA_RS02640	COG2086	electron transfer activity
HALSA_RS02645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HALSA_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS02655	COG1070	Carbohydrate kinase
HALSA_RS02660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HALSA_RS02665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HALSA_RS02705	COG2972	Histidine kinase
HALSA_RS02705	COG0745	RESPONSE REGULATOR receiver
HALSA_RS02710	COG5001	Diguanylate cyclase
HALSA_RS02715	COG3279	Response regulator of the LytR AlgR family
HALSA_RS02765	COG2801	Transposase and inactivated derivatives
HALSA_RS02780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HALSA_RS02790	COG3344	reverse transcriptase
HALSA_RS02825	COG2801	Transposase and inactivated derivatives
HALSA_RS02830	COG3206	protein involved in exopolysaccharide biosynthesis
HALSA_RS02830	COG0489	protein tyrosine kinase activity
HALSA_RS02850	COG0653	protein targeting
HALSA_RS02875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALSA_RS02880	COG1454	alcohol dehydrogenase
HALSA_RS02885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HALSA_RS02895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HALSA_RS02935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HALSA_RS02945	COG2801	Transposase and inactivated derivatives
HALSA_RS02960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALSA_RS02965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HALSA_RS02965	COG0662	Cupin 2, conserved barrel domain protein
HALSA_RS02975	COG1061	Type III restriction enzyme res subunit
HALSA_RS03080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HALSA_RS03140	COG2801	Transposase and inactivated derivatives
HALSA_RS03150	COG3279	Response regulator of the LytR AlgR family
HALSA_RS03160	COG2204	response regulator
HALSA_RS03160	COG5564	TIM-barrel signal transduction protein
HALSA_RS03170	COG2204	response regulator
HALSA_RS03180	COG5564	TIM-barrel signal transduction protein
HALSA_RS03185	COG0471	metal ion transport
HALSA_RS03195	COG1132	(ABC) transporter
HALSA_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALSA_RS03235	COG1091	dTDP-4-dehydrorhamnose reductase activity
HALSA_RS03245	COG1215	transferase activity, transferring glycosyl groups
HALSA_RS03275	COG1993	acr, cog1993
HALSA_RS03295	COG2226	methyltransferase
HALSA_RS03305	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HALSA_RS03305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HALSA_RS03315	COG3414	Phosphotransferase system galactitol-specific IIB component
HALSA_RS03320	COG3775	system Galactitol-specific IIC component
HALSA_RS03340	COG1879	ABC-type sugar transport system periplasmic component
HALSA_RS03345	COG1129	ABC transporter
HALSA_RS03350	COG1172	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS03355	COG0159	tryptophan synthase activity
HALSA_RS03360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HALSA_RS03370	COG2239	Acts as a magnesium transporter
HALSA_RS03380	COG0656	L-ascorbic acid biosynthetic process
HALSA_RS03390	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALSA_RS03395	COG1349	DNA-binding transcription factor activity
HALSA_RS03410	COG0698	ribose 5-phosphate isomerase
HALSA_RS03415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HALSA_RS03420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HALSA_RS03425	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HALSA_RS03435	COG1070	Carbohydrate kinase
HALSA_RS03445	COG1063	alcohol dehydrogenase
HALSA_RS03450	COG1349	DNA-binding transcription factor activity
HALSA_RS03455	COG0371	Dehydrogenase
HALSA_RS03460	COG0647	UMP catabolic process
HALSA_RS03465	COG2376	Dihydroxyacetone kinase
HALSA_RS03470	COG1368	sulfuric ester hydrolase activity
HALSA_RS03475	COG0584	glycerophosphoryl diester phosphodiesterase
HALSA_RS03480	COG1979	alcohol dehydrogenase
HALSA_RS03485	COG1863	multisubunit Na H antiporter MnhE subunit
HALSA_RS03490	COG2212	antiporter activity
HALSA_RS03495	COG1320	monovalent cation:proton antiporter activity
HALSA_RS03515	COG0651	ATP synthesis coupled electron transport
HALSA_RS03520	COG0651	ATP synthesis coupled electron transport
HALSA_RS03525	COG1473	amidohydrolase
HALSA_RS03530	COG0436	Aminotransferase
HALSA_RS03550	COG2358	TRAP transporter, solute receptor (TAXI family
HALSA_RS03575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HALSA_RS03580	COG0659	secondary active sulfate transmembrane transporter activity
HALSA_RS03585	COG0471	metal ion transport
HALSA_RS03585	COG3273	potassium ion transport
HALSA_RS03600	COG3859	Proton-coupled thiamine transporter YuaJ
HALSA_RS03610	COG0352	thiamine-phosphate diphosphorylase activity
HALSA_RS03610	COG0351	phosphomethylpyrimidine kinase
HALSA_RS03615	COG0352	thiamine-phosphate diphosphorylase activity
HALSA_RS03620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HALSA_RS03625	COG2226	methyltransferase
HALSA_RS03630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HALSA_RS03635	COG0535	radical SAM domain protein
HALSA_RS03655	COG1882	Formate acetyltransferase
HALSA_RS03665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HALSA_RS03680	COG2414	aldehyde ferredoxin oxidoreductase
HALSA_RS03690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HALSA_RS03705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HALSA_RS03710	COG0137	argininosuccinate synthase activity
HALSA_RS03715	COG0165	Argininosuccinate lyase
HALSA_RS03720	COG0501	Belongs to the peptidase M48B family
HALSA_RS03725	COG0038	chloride channel
HALSA_RS03755	COG3328	transposase activity
HALSA_RS03765	COG1482	cell wall glycoprotein biosynthetic process
HALSA_RS03770	COG1414	Transcriptional regulator
HALSA_RS03785	COG1924	4 iron, 4 sulfur cluster binding
HALSA_RS03790	COG0114	fumarate hydratase activity
HALSA_RS03795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS03795	COG2199	diguanylate cyclase activity
HALSA_RS03805	COG1309	transcriptional regulator
HALSA_RS03830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HALSA_RS03840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HALSA_RS03845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HALSA_RS03850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALSA_RS03855	COG0653	protein targeting
HALSA_RS03875	COG1011	Hydrolase
HALSA_RS03880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HALSA_RS03880	COG3264	Mechanosensitive ion channel
HALSA_RS03885	COG0693	protein deglycase activity
HALSA_RS03890	COG0058	SHG alpha-glucan phosphorylase activity
HALSA_RS03895	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS03900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HALSA_RS03905	COG1523	belongs to the glycosyl hydrolase 13 family
HALSA_RS03915	COG1115	amino acid carrier protein
HALSA_RS03920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HALSA_RS03930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HALSA_RS03935	COG0297	glycogen (starch) synthase activity
HALSA_RS03960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HALSA_RS03965	COG1116	anion transmembrane transporter activity
HALSA_RS03975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALSA_RS03985	COG1659	Linocin_M18 bacteriocin protein
HALSA_RS03990	COG0731	radical SAM domain protein
HALSA_RS03990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HALSA_RS03995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALSA_RS04000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALSA_RS04010	COG0632	four-way junction helicase activity
HALSA_RS04020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HALSA_RS04025	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALSA_RS04025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALSA_RS04030	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALSA_RS04040	COG1151	hydroxylamine reductase activity
HALSA_RS04050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HALSA_RS04055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HALSA_RS04060	COG3639	organic phosphonate transmembrane transporter activity
HALSA_RS04075	COG1027	Aspartate ammonia-lyase
HALSA_RS04095	COG4658	electron transport chain
HALSA_RS04110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HALSA_RS04120	COG1461	Dihydroxyacetone kinase
HALSA_RS04130	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS04135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HALSA_RS04140	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HALSA_RS04145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HALSA_RS04185	COG2221	Nitrite and sulphite reductase 4Fe-4S
HALSA_RS04190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HALSA_RS04195	COG0561	phosphatase activity
HALSA_RS04210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HALSA_RS04225	COG1660	Displays ATPase and GTPase activities
HALSA_RS04230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HALSA_RS04235	COG1481	regulation of sporulation
HALSA_RS04255	COG0149	triose-phosphate isomerase activity
HALSA_RS04260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HALSA_RS04265	COG0148	phosphopyruvate hydratase activity
HALSA_RS04275	COG3328	transposase activity
HALSA_RS04295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HALSA_RS04300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HALSA_RS04305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HALSA_RS04320	COG0557	exoribonuclease II activity
HALSA_RS04325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HALSA_RS04335	COG2770	Histidine kinase
HALSA_RS04335	COG3437	response regulator, receiver
HALSA_RS04340	COG0668	transmembrane transport
HALSA_RS04345	COG1550	Protein conserved in bacteria
HALSA_RS04380	COG3292	Two component regulator propeller
HALSA_RS04380	COG0745	RESPONSE REGULATOR receiver
HALSA_RS04380	COG2205	protein histidine kinase activity
HALSA_RS04385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HALSA_RS04395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HALSA_RS04400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HALSA_RS04460	COG0544	peptidyl-prolyl cis-trans isomerase activity
HALSA_RS04465	COG0740	serine-type endopeptidase activity
HALSA_RS04470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HALSA_RS04475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HALSA_RS04480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HALSA_RS04490	COG1252	NADH dehydrogenase
HALSA_RS04505	COG0142	geranyltranstransferase activity
HALSA_RS04510	COG0450	alkyl hydroperoxide reductase
HALSA_RS04525	COG2972	Histidine kinase
HALSA_RS04530	COG2207	Transcriptional regulator
HALSA_RS04530	COG4753	response regulator
HALSA_RS04535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HALSA_RS04555	COG3830	Belongs to the UPF0237 family
HALSA_RS04560	COG2848	UPF0210 protein
HALSA_RS04565	COG2267	carboxylic ester hydrolase activity
HALSA_RS04570	COG1802	Transcriptional regulator
HALSA_RS04575	COG1802	Transcriptional regulator
HALSA_RS04585	COG1175	transmembrane transport
HALSA_RS04595	COG1312	Catalyzes the dehydration of D-mannonate
HALSA_RS04600	COG0246	Mannitol dehydrogenase
HALSA_RS04620	COG0246	Mannitol dehydrogenase
HALSA_RS04630	COG1904	glucuronate isomerase
HALSA_RS04635	COG2721	sulfolactate sulfo-lyase activity
HALSA_RS04665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALSA_RS04670	COG0022	dehydrogenase e1 component
HALSA_RS04675	COG3199	ATP-NAD kinase
HALSA_RS04685	COG0508	dehydrogenase complex catalyzes the overall conversion of
HALSA_RS04700	COG1063	alcohol dehydrogenase
HALSA_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS04710	COG2153	protein acetylation
HALSA_RS04715	COG0483	inositol monophosphate 1-phosphatase activity
HALSA_RS04735	COG0737	Belongs to the 5'-nucleotidase family
HALSA_RS04740	COG0737	Belongs to the 5'-nucleotidase family
HALSA_RS04775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HALSA_RS04795	COG1229	Formylmethanofuran dehydrogenase subunit A
HALSA_RS04800	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
HALSA_RS04810	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HALSA_RS04815	COG0189	ligase activity
HALSA_RS04830	COG1891	lyase activity
HALSA_RS04850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HALSA_RS04860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HALSA_RS04870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HALSA_RS04875	COG2873	o-acetylhomoserine
HALSA_RS04880	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HALSA_RS04885	COG0813	purine-nucleoside phosphorylase activity
HALSA_RS04890	COG1272	protein, Hemolysin III
HALSA_RS04895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HALSA_RS04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS04905	COG0601	transmembrane transport
HALSA_RS04915	COG2378	regulation of single-species biofilm formation
HALSA_RS04925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALSA_RS04935	COG0656	L-ascorbic acid biosynthetic process
HALSA_RS04940	COG1597	lipid kinase activity
HALSA_RS04960	COG1994	Peptidase M50
HALSA_RS04960	COG0517	IMP dehydrogenase activity
HALSA_RS04965	COG2972	Histidine kinase
HALSA_RS04970	COG2197	response regulator
HALSA_RS05010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HALSA_RS05020	COG4820	ethanolamine utilization protein (EutJ)
HALSA_RS05035	COG2096	Adenosyltransferase
HALSA_RS05045	COG1012	belongs to the aldehyde dehydrogenase family
HALSA_RS05050	COG4656	Part of a membrane complex involved in electron transport
HALSA_RS05065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HALSA_RS05085	COG4869	propanediol catabolic process
HALSA_RS05145	COG0726	polysaccharide deacetylase
HALSA_RS05155	COG5012	cobalamin binding
HALSA_RS05160	COG2207	Transcriptional regulator
HALSA_RS05200	COG2801	Transposase and inactivated derivatives
HALSA_RS05210	COG0628	permease
HALSA_RS05220	COG3328	transposase activity
HALSA_RS05300	COG3328	transposase activity
HALSA_RS05325	COG5002	protein histidine kinase activity
HALSA_RS05335	COG2204	response regulator
HALSA_RS05355	COG2391	methyltransferase activity
HALSA_RS05365	COG0471	metal ion transport
HALSA_RS05365	COG3273	potassium ion transport
HALSA_RS05400	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HALSA_RS05410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HALSA_RS05425	COG2801	Transposase and inactivated derivatives
HALSA_RS05435	COG3250	beta-galactosidase activity
HALSA_RS05495	COG0739	heme binding
HALSA_RS05505	COG2217	Heavy metal translocating P-type atpase
HALSA_RS05510	COG0640	Transcriptional regulator
HALSA_RS05520	COG0746	molybdenum cofactor guanylyltransferase activity
HALSA_RS05530	COG0525	valine-tRNA ligase activity
HALSA_RS05540	COG0303	'Molybdopterin
HALSA_RS05550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HALSA_RS05555	COG0315	cyclic pyranopterin monophosphate synthase activity
HALSA_RS05560	COG0521	Mo-molybdopterin cofactor biosynthetic process
HALSA_RS05575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HALSA_RS05580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HALSA_RS05585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HALSA_RS05605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HALSA_RS05615	COG0285	dihydrofolate synthase activity
HALSA_RS05625	COG4656	Part of a membrane complex involved in electron transport
HALSA_RS05630	COG4658	electron transport chain
HALSA_RS05635	COG4659	FMN binding
HALSA_RS05640	COG4660	Part of a membrane complex involved in electron transport
HALSA_RS05645	COG4657	Part of a membrane complex involved in electron transport
HALSA_RS05650	COG2878	Part of a membrane complex involved in electron transport
HALSA_RS05650	COG1245	4Fe-4S binding domain
HALSA_RS05655	COG3344	reverse transcriptase
HALSA_RS05670	COG0424	maF-like protein
HALSA_RS05675	COG2003	Belongs to the UPF0758 family
HALSA_RS05680	COG1077	Cell shape determining protein MreB Mrl
HALSA_RS05695	COG0768	penicillin binding
HALSA_RS05700	COG0850	regulation of cytokinetic process
HALSA_RS05705	COG2894	cell division
HALSA_RS05710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HALSA_RS05715	COG0772	Belongs to the SEDS family
HALSA_RS05730	COG1530	ribonuclease E activity
HALSA_RS05735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HALSA_RS05740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HALSA_RS05745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HALSA_RS05750	COG1534	Rna-binding protein
HALSA_RS05755	COG1307	EDD domain protein, DegV family
HALSA_RS05760	COG0488	(ABC) transporter
HALSA_RS05765	COG0347	Belongs to the P(II) protein family
HALSA_RS05770	COG0004	ammonium transporteR
HALSA_RS05775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HALSA_RS05785	COG0028	Belongs to the TPP enzyme family
HALSA_RS05790	COG1368	sulfuric ester hydrolase activity
HALSA_RS05800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HALSA_RS05800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HALSA_RS05805	COG0307	riboflavin synthase, alpha
HALSA_RS05810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HALSA_RS05810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HALSA_RS05815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HALSA_RS05840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HALSA_RS05840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HALSA_RS05845	COG2056	Na+-H+ antiporter family
HALSA_RS05850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALSA_RS05855	COG0667	Aldo Keto reductase
HALSA_RS05890	COG0471	metal ion transport
HALSA_RS05900	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HALSA_RS05905	COG3711	transcriptional antiterminator
HALSA_RS05910	COG2213	PTS system mannitol-specific
HALSA_RS05910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS05915	COG1105	Belongs to the carbohydrate kinase PfkB family
HALSA_RS05920	COG1063	alcohol dehydrogenase
HALSA_RS05925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS05945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HALSA_RS05970	COG0561	phosphatase activity
HALSA_RS05975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HALSA_RS05980	COG1288	antiporter activity
HALSA_RS05985	COG0281	malic enzyme
HALSA_RS06005	COG0460	homoserine dehydrogenase
HALSA_RS06020	COG0398	Pfam SNARE associated Golgi protein
HALSA_RS06035	COG1331	Highly conserved protein containing a thioredoxin domain
HALSA_RS06045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HALSA_RS06050	COG0372	Belongs to the citrate synthase family
HALSA_RS06060	COG0300	oxidoreductase activity
HALSA_RS06065	COG3579	cysteine-type endopeptidase activity
HALSA_RS06070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALSA_RS06075	COG1295	ribonuclease BN
HALSA_RS06085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HALSA_RS06110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HALSA_RS06115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HALSA_RS06125	COG0513	Belongs to the DEAD box helicase family
HALSA_RS06130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HALSA_RS06140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALSA_RS06145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HALSA_RS06150	COG2171	N-acyltransferase activity
HALSA_RS06155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALSA_RS06160	COG4974	Belongs to the 'phage' integrase family
HALSA_RS06165	COG0542	response to heat
HALSA_RS06190	COG3177	Filamentation induced by cAMP protein fic
HALSA_RS06225	COG0655	NAD(P)H dehydrogenase (quinone) activity
HALSA_RS06230	COG0133	tryptophan synthase activity
HALSA_RS06235	COG2188	Transcriptional regulator
HALSA_RS06250	COG2801	Transposase and inactivated derivatives
HALSA_RS06255	COG2059	Chromate
HALSA_RS06265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HALSA_RS06275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HALSA_RS06280	COG1573	uracil-dna glycosylase
HALSA_RS06290	COG1923	regulation of RNA biosynthetic process
HALSA_RS06300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HALSA_RS06305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HALSA_RS06310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALSA_RS06315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HALSA_RS06320	COG0569	domain protein
HALSA_RS06325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALSA_RS06330	COG1773	rubredoxin
HALSA_RS06335	COG0038	chloride channel
HALSA_RS06345	COG0187	DNA topoisomerase II activity
HALSA_RS06350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HALSA_RS06355	COG3773	Cell wall hydrolase
HALSA_RS06360	COG1196	nuclear chromosome segregation
HALSA_RS06375	COG0848	biopolymer transport protein
HALSA_RS06380	COG0811	peptide transport
HALSA_RS06385	COG2205	protein histidine kinase activity
HALSA_RS06390	COG0745	RESPONSE REGULATOR receiver
HALSA_RS06395	COG2359	stage V sporulation protein S
HALSA_RS06400	COG1692	metallophosphoesterase
HALSA_RS06405	COG1418	mRNA catabolic process
HALSA_RS06415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HALSA_RS06430	COG1546	Belongs to the CinA family
HALSA_RS06430	COG1058	Belongs to the CinA family
HALSA_RS06435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HALSA_RS06440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HALSA_RS06445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HALSA_RS06470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALSA_RS06475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALSA_RS06490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALSA_RS06500	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HALSA_RS06505	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HALSA_RS06510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HALSA_RS06535	COG1079	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS06540	COG4603	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS06545	COG3845	ABC transporter
HALSA_RS06550	COG1744	ABC transporter substrate-binding protein PnrA-like
HALSA_RS06555	COG1674	ftsk spoiiie
HALSA_RS06560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HALSA_RS06565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HALSA_RS06570	COG0697	spore germination
HALSA_RS06575	COG0116	Belongs to the methyltransferase superfamily
HALSA_RS06580	COG1335	isochorismatase
HALSA_RS06585	COG1254	Belongs to the acylphosphatase family
HALSA_RS06590	COG3634	alkyl hydroperoxide reductase activity
HALSA_RS06600	COG2081	HI0933 family
HALSA_RS06605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HALSA_RS06615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALSA_RS06625	COG1164	Oligoendopeptidase f
HALSA_RS06630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HALSA_RS06650	COG0460	homoserine dehydrogenase
HALSA_RS06655	COG0083	homoserine kinase activity
HALSA_RS06665	COG0756	dUTP diphosphatase activity
HALSA_RS06675	COG1199	ATP-dependent helicase activity
HALSA_RS06680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HALSA_RS06685	COG1185	polyribonucleotide nucleotidyltransferase activity
HALSA_RS06690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HALSA_RS06695	COG0196	riboflavin kinase activity
HALSA_RS06700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HALSA_RS06705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALSA_RS06710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HALSA_RS06715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HALSA_RS06725	COG0195	Participates in both transcription termination and antitermination
HALSA_RS06730	COG0779	Required for maturation of 30S ribosomal subunits
HALSA_RS06740	COG0442	prolyl-tRNA aminoacylation
HALSA_RS06750	COG0750	zinc metalloprotease
HALSA_RS06755	COG0628	permease
HALSA_RS06760	COG4589	Belongs to the CDS family
HALSA_RS06765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HALSA_RS06775	COG0233	cytoplasmic translational termination
HALSA_RS06780	COG0528	UMP kinase activity
HALSA_RS06785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HALSA_RS06790	COG0052	Belongs to the universal ribosomal protein uS2 family
HALSA_RS06795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HALSA_RS06800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HALSA_RS06805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HALSA_RS06810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HALSA_RS06820	COG0758	DNA mediated transformation
HALSA_RS06825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALSA_RS06840	COG0848	biopolymer transport protein
HALSA_RS06845	COG0811	peptide transport
HALSA_RS06855	COG4206	TonB-dependent receptor
HALSA_RS06860	COG0792	nuclease activity
HALSA_RS06865	COG0606	chelatase, subunit chli
HALSA_RS06875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HALSA_RS06890	COG4752	Belongs to the RNA methyltransferase TrmD family
HALSA_RS06895	COG0336	Belongs to the RNA methyltransferase TrmD family
HALSA_RS06900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HALSA_RS06905	COG1837	Belongs to the UPF0109 family
HALSA_RS06910	COG0228	four-way junction DNA binding
HALSA_RS06915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HALSA_RS06920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HALSA_RS06925	COG0552	protein localization to endoplasmic reticulum
HALSA_RS06930	COG1196	nuclear chromosome segregation
HALSA_RS06935	COG2359	stage V sporulation protein S
HALSA_RS06940	COG1187	pseudouridine synthase activity
HALSA_RS06950	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HALSA_RS06955	COG1994	Peptidase M50
HALSA_RS06960	COG0617	tRNA 3'-terminal CCA addition
HALSA_RS06960	COG3620	sequence-specific DNA binding
HALSA_RS06960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALSA_RS06975	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HALSA_RS06980	COG2309	aminopeptidase activity
HALSA_RS06985	COG1379	DNA repair
HALSA_RS06990	COG0494	nUDIX hydrolase
HALSA_RS06995	COG0745	RESPONSE REGULATOR receiver
HALSA_RS07000	COG0497	DNA recombination
HALSA_RS07005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HALSA_RS07010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HALSA_RS07015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HALSA_RS07025	COG0142	geranyltranstransferase activity
HALSA_RS07030	COG1722	exodeoxyribonuclease VII activity
HALSA_RS07035	COG1570	exodeoxyribonuclease VII activity
HALSA_RS07040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HALSA_RS07040	COG0493	'glutamate synthase
HALSA_RS07060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HALSA_RS07075	COG1302	Protein conserved in bacteria
HALSA_RS07080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HALSA_RS07085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HALSA_RS07090	COG0006	proline dipeptidase activity
HALSA_RS07095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HALSA_RS07100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HALSA_RS07165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HALSA_RS07170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALSA_RS07175	COG0473	3-isopropylmalate dehydrogenase activity
HALSA_RS07180	COG0066	3-isopropylmalate dehydratase activity
HALSA_RS07185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HALSA_RS07190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALSA_RS07195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HALSA_RS07200	COG0440	acetolactate synthase activity
HALSA_RS07205	COG0028	Belongs to the TPP enzyme family
HALSA_RS07210	COG0129	dihydroxy-acid dehydratase activity
HALSA_RS07230	COG2197	response regulator
HALSA_RS07290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HALSA_RS07305	COG1459	type II secretion system
HALSA_RS07315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HALSA_RS07320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HALSA_RS07325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HALSA_RS07330	COG0735	belongs to the Fur family
HALSA_RS07335	COG2002	toxin-antitoxin pair type II binding
HALSA_RS07350	COG0826	peptidase U32
HALSA_RS07355	COG4122	O-methyltransferase activity
HALSA_RS07370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HALSA_RS07375	COG4472	Bacterial protein of unknown function (DUF965)
HALSA_RS07380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HALSA_RS07385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HALSA_RS07390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HALSA_RS07395	COG1193	negative regulation of DNA recombination
HALSA_RS07400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HALSA_RS07400	COG1796	DNA polymerase
HALSA_RS07415	COG0072	phenylalanine-tRNA ligase activity
HALSA_RS07420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HALSA_RS07425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HALSA_RS07430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HALSA_RS07435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HALSA_RS07440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HALSA_RS07535	COG1785	Belongs to the alkaline phosphatase family
HALSA_RS07565	COG1785	Belongs to the alkaline phosphatase family
HALSA_RS07630	COG1105	Belongs to the carbohydrate kinase PfkB family
HALSA_RS07640	COG1321	iron dependent repressor
HALSA_RS07645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HALSA_RS07650	COG1121	(ABC) transporter
HALSA_RS07655	COG0803	Belongs to the bacterial solute-binding protein 9 family
HALSA_RS07670	COG2081	HI0933 family
HALSA_RS07675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HALSA_RS07695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HALSA_RS07700	COG2086	electron transfer activity
HALSA_RS07725	COG0739	heme binding
HALSA_RS07735	COG0321	lipoyl(octanoyl) transferase activity
HALSA_RS07735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HALSA_RS07745	COG2247	cell wall binding repeat
HALSA_RS07745	COG2385	sporulation resulting in formation of a cellular spore
HALSA_RS07750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HALSA_RS07760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HALSA_RS07765	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HALSA_RS07775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HALSA_RS07785	COG0612	Peptidase, M16
HALSA_RS07790	COG0612	Peptidase, M16
HALSA_RS07795	COG1615	UPF0182 protein
HALSA_RS07800	COG0402	S-adenosylhomocysteine deaminase activity
HALSA_RS07815	COG0415	Belongs to the DNA photolyase family
HALSA_RS07820	COG0668	transmembrane transport
HALSA_RS07825	COG0776	regulation of translation
HALSA_RS07830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HALSA_RS07835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HALSA_RS07840	COG1160	GTP binding
HALSA_RS07855	COG0204	Acyl-transferase
HALSA_RS07865	COG4401	Chorismate mutase type I
HALSA_RS07875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HALSA_RS07885	COG2070	2-Nitropropane dioxygenase
HALSA_RS07890	COG0416	fatty acid biosynthetic process
HALSA_RS07895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HALSA_RS07905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HALSA_RS07910	COG0280	phosphate acetyltransferase
HALSA_RS07915	COG1323	Belongs to the UPF0348 family
HALSA_RS07920	COG3480	Lon protease (S16) C-terminal proteolytic domain
HALSA_RS07925	COG1752	Esterase of the alpha-beta hydrolase superfamily
HALSA_RS07930	COG1757	Na H antiporter
HALSA_RS07935	COG0037	tRNA processing
HALSA_RS07950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HALSA_RS07955	COG0742	ribosomal rna small subunit methyltransferase
HALSA_RS07960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HALSA_RS07970	COG1461	Dihydroxyacetone kinase
HALSA_RS07975	COG1302	Protein conserved in bacteria
HALSA_RS07980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HALSA_RS07990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HALSA_RS07995	COG1162	GTPase activity
HALSA_RS08000	COG2815	serine threonine protein kinase
HALSA_RS08000	COG0515	serine threonine protein kinase
HALSA_RS08010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HALSA_RS08025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HALSA_RS08030	COG0242	peptide deformylase activity
HALSA_RS08035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HALSA_RS08040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HALSA_RS08045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HALSA_RS08050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HALSA_RS08055	COG1758	RNA polymerase activity
HALSA_RS08060	COG0194	GDP metabolic process
HALSA_RS08065	COG2052	Domain of unknown function (DUF370)
HALSA_RS08080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HALSA_RS08090	COG0564	pseudouridine synthase activity
HALSA_RS08095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HALSA_RS08100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HALSA_RS08105	COG3599	regulation of cell shape
HALSA_RS08110	COG2302	S4 RNA-binding domain
HALSA_RS08120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HALSA_RS08130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALSA_RS08145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HALSA_RS08150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HALSA_RS08155	COG0772	Belongs to the SEDS family
HALSA_RS08165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HALSA_RS08170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HALSA_RS08175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HALSA_RS08180	COG0768	penicillin binding
HALSA_RS08190	COG0275	rRNA processing
HALSA_RS08195	COG2001	Belongs to the MraZ family
HALSA_RS08200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HALSA_RS08205	COG1181	Belongs to the D-alanine--D-alanine ligase family
HALSA_RS08210	COG0180	Tryptophanyl-tRNA synthetase
HALSA_RS08230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HALSA_RS08235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS08250	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALSA_RS08260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS08265	COG0601	transmembrane transport
HALSA_RS08315	COG0482	sulfurtransferase activity
HALSA_RS08320	COG1104	cysteine desulfurase activity
HALSA_RS08325	COG1959	2 iron, 2 sulfur cluster binding
HALSA_RS08330	COG1739	Uncharacterized protein family UPF0029
HALSA_RS08335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HALSA_RS08340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HALSA_RS08345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HALSA_RS08350	COG0124	histidyl-tRNA synthetase
HALSA_RS08360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALSA_RS08365	COG1490	D-aminoacyl-tRNA deacylase activity
HALSA_RS08370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HALSA_RS08375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HALSA_RS08380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HALSA_RS08380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HALSA_RS08390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HALSA_RS08395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HALSA_RS08405	COG1862	Preprotein translocase
HALSA_RS08410	COG0343	queuine tRNA-ribosyltransferase activity
HALSA_RS08415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HALSA_RS08420	COG2255	four-way junction helicase activity
HALSA_RS08425	COG0632	four-way junction helicase activity
HALSA_RS08430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HALSA_RS08435	COG0217	transcriptional regulatory protein
HALSA_RS08450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HALSA_RS08465	COG0358	DNA primase activity
HALSA_RS08470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HALSA_RS08475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HALSA_RS08480	COG0751	glycine-tRNA ligase activity
HALSA_RS08485	COG0752	glycyl-tRNA synthetase alpha subunit
HALSA_RS08490	COG1381	Involved in DNA repair and RecF pathway recombination
HALSA_RS08495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HALSA_RS08500	COG2239	Acts as a magnesium transporter
HALSA_RS08505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HALSA_RS08515	COG1470	cell adhesion involved in biofilm formation
HALSA_RS08520	COG4536	flavin adenine dinucleotide binding
HALSA_RS08525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HALSA_RS08530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HALSA_RS08535	COG1480	7TM receptor with intracellular HD hydrolase
HALSA_RS08540	COG1702	phosphate starvation-inducible protein PhoH
HALSA_RS08550	COG4864	UPF0365 protein
HALSA_RS08555	COG1030	water channel activity
HALSA_RS08560	COG1610	YqeY-like protein
HALSA_RS08565	COG0537	adenosine 5'-monophosphoramidase activity
HALSA_RS08570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HALSA_RS08575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HALSA_RS08580	COG0484	heat shock protein binding
HALSA_RS08585	COG0443	Heat shock 70 kDa protein
HALSA_RS08590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HALSA_RS08595	COG1420	regulation of RNA biosynthetic process
HALSA_RS08600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HALSA_RS08605	COG0481	GTPase activity
HALSA_RS08610	COG0268	Binds directly to 16S ribosomal RNA
HALSA_RS08630	COG0572	uridine kinase
HALSA_RS08650	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HALSA_RS08655	COG2217	Heavy metal translocating P-type atpase
HALSA_RS08665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HALSA_RS08670	COG0534	Mate efflux family protein
HALSA_RS08680	COG0495	leucyl-tRNA aminoacylation
HALSA_RS08685	COG0799	negative regulation of ribosome biogenesis
HALSA_RS08690	COG1316	TRANSCRIPTIONal
HALSA_RS08700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HALSA_RS08710	COG1410	methionine synthase
HALSA_RS08710	COG0646	methionine synthase
HALSA_RS08720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HALSA_RS08730	COG2217	Heavy metal translocating P-type atpase
HALSA_RS08750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALSA_RS08755	COG1959	2 iron, 2 sulfur cluster binding
HALSA_RS08765	COG2996	Protein conserved in bacteria
HALSA_RS08785	COG1597	lipid kinase activity
HALSA_RS08790	COG2223	nitrite transmembrane transporter activity
HALSA_RS08795	COG0708	Exodeoxyribonuclease III
HALSA_RS08805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HALSA_RS08825	COG0778	Nitroreductase
HALSA_RS08830	COG0733	neurotransmitter:sodium symporter activity
HALSA_RS08850	COG2984	ABC transporter substrate binding protein
HALSA_RS08855	COG4120	Belongs to the binding-protein-dependent transport system permease family
HALSA_RS08870	COG1554	hydrolase, family 65, central catalytic
HALSA_RS08885	COG1653	transport
HALSA_RS08890	COG1609	Transcriptional regulator
HALSA_RS08900	COG4608	Belongs to the ABC transporter superfamily
HALSA_RS08905	COG0444	Belongs to the ABC transporter superfamily
HALSA_RS08910	COG0741	lytic transglycosylase activity
HALSA_RS08915	COG1803	Methylglyoxal synthase
HALSA_RS08925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HALSA_RS08930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HALSA_RS08930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HALSA_RS08935	COG5002	protein histidine kinase activity
HALSA_RS08940	COG0745	RESPONSE REGULATOR receiver
HALSA_RS08945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HALSA_RS08950	COG0588	phosphoglycerate mutase activity
HALSA_RS08965	COG0167	dihydroorotate dehydrogenase activity
HALSA_RS08970	COG0543	2 iron, 2 sulfur cluster binding
HALSA_RS08975	COG0284	orotidine-5'-phosphate decarboxylase activity
HALSA_RS08985	COG0540	Belongs to the ATCase OTCase family
HALSA_RS08990	COG2233	PERMEase
HALSA_RS08995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HALSA_RS09010	COG0505	Belongs to the CarA family
HALSA_RS09020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HALSA_RS09025	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HALSA_RS09065	COG1278	Cold shock
HALSA_RS09070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALSA_RS09090	COG1125	glycine betaine transport
HALSA_RS09090	COG0517	IMP dehydrogenase activity
HALSA_RS09095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HALSA_RS09100	COG1397	ADP-ribosylglycohydrolase
HALSA_RS09115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HALSA_RS09125	COG2801	Transposase and inactivated derivatives
HALSA_RS09175	COG3328	transposase activity
HALSA_RS09180	COG3404	Formiminotransferase-cyclodeaminase
HALSA_RS09185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HALSA_RS09225	COG1454	alcohol dehydrogenase
HALSA_RS09235	COG4475	Protein of unknown function (DUF436)
HALSA_RS09250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HALSA_RS09260	COG0205	6-phosphofructokinase activity
HALSA_RS09275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HALSA_RS09280	COG3679	Belongs to the UPF0342 family
HALSA_RS09290	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HALSA_RS09305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HALSA_RS09310	COG0534	Mate efflux family protein
HALSA_RS09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALSA_RS09330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALSA_RS09335	COG0154	amidase activity
HALSA_RS09340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALSA_RS09345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HALSA_RS09350	COG0210	DNA helicase
HALSA_RS09360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HALSA_RS09365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HALSA_RS09375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HALSA_RS09375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HALSA_RS09385	COG0210	DNA helicase
HALSA_RS09405	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HALSA_RS09410	COG4496	protein, YerC YecD
HALSA_RS09415	COG0519	Catalyzes the synthesis of GMP from XMP
HALSA_RS09415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALSA_RS09420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HALSA_RS09420	COG0574	Belongs to the PEP-utilizing enzyme family
HALSA_RS09425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HALSA_RS09430	COG0459	protein refolding
HALSA_RS09435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HALSA_RS09445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HALSA_RS09450	COG1214	PFAM Peptidase M22, glycoprotease
HALSA_RS09460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HALSA_RS09465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HALSA_RS09495	COG3852	Histidine kinase
HALSA_RS09500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HALSA_RS09505	COG0613	PHP domain protein
HALSA_RS09530	COG2337	Toxic component of a toxin-antitoxin (TA) module
HALSA_RS09540	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HALSA_RS09545	COG0717	Belongs to the dCTP deaminase family
HALSA_RS09550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HALSA_RS09550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HALSA_RS09555	COG0736	holo-[acyl-carrier-protein] synthase activity
HALSA_RS09560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HALSA_RS09565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALSA_RS09575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HALSA_RS09590	COG2078	PFAM AMMECR1 domain protein
HALSA_RS09595	COG3885	ferrous iron binding
HALSA_RS09595	COG2078	PFAM AMMECR1 domain protein
HALSA_RS09600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HALSA_RS09605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HALSA_RS09610	COG0101	tRNA pseudouridine synthase activity
HALSA_RS09615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HALSA_RS09625	COG1122	ATPase activity
HALSA_RS09630	COG0203	ribosomal protein L17
HALSA_RS09635	COG0202	RNA polymerase activity
HALSA_RS09640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HALSA_RS09645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HALSA_RS09650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HALSA_RS09655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HALSA_RS09660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HALSA_RS09670	COG0563	adenylate kinase activity
HALSA_RS09675	COG0201	protein transport
HALSA_RS09680	COG0200	Binds to the 23S rRNA
HALSA_RS09685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HALSA_RS09690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HALSA_RS09695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HALSA_RS09700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HALSA_RS09705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HALSA_RS09710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HALSA_RS09715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HALSA_RS09720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HALSA_RS09725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HALSA_RS09730	COG0255	Belongs to the universal ribosomal protein uL29 family
HALSA_RS09735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HALSA_RS09740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HALSA_RS09745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HALSA_RS09750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HALSA_RS09755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HALSA_RS09760	COG0089	rRNA binding
HALSA_RS09765	COG0088	Forms part of the polypeptide exit tunnel
HALSA_RS09770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HALSA_RS09775	COG0051	transcription antitermination factor activity, RNA binding
HALSA_RS09780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALSA_RS09785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HALSA_RS09790	COG0049	tRNA binding
HALSA_RS09795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HALSA_RS09805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HALSA_RS09810	COG0085	RNA polymerase activity
HALSA_RS09820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HALSA_RS09825	COG0081	regulation of translation
HALSA_RS09830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HALSA_RS09835	COG0250	Participates in transcription elongation, termination and antitermination
HALSA_RS09840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HALSA_RS09850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALSA_RS09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HALSA_RS09870	COG0215	cysteine-tRNA ligase activity
HALSA_RS09875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HALSA_RS09880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALSA_RS09880	COG0517	IMP dehydrogenase activity
HALSA_RS09880	COG0617	tRNA 3'-terminal CCA addition
HALSA_RS09885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HALSA_RS09890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HALSA_RS09895	COG4956	integral membrane protein (PIN domain superfamily)
HALSA_RS09900	COG1329	Transcriptional regulator
HALSA_RS09905	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HALSA_RS09915	COG0542	response to heat
HALSA_RS09920	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HALSA_RS09925	COG3880	PFAM UvrB UvrC protein
HALSA_RS09930	COG4463	regulation of RNA biosynthetic process
HALSA_RS09965	COG0432	Pfam Uncharacterised protein family UPF0047
HALSA_RS09970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HALSA_RS09980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HALSA_RS09985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HALSA_RS09995	COG1744	ABC transporter substrate-binding protein PnrA-like
HALSA_RS10010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HALSA_RS10015	COG0390	transport system, permease component
HALSA_RS10020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HALSA_RS10025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALSA_RS10030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HALSA_RS10035	COG0037	tRNA processing
HALSA_RS10040	COG0248	Ppx GppA phosphatase
HALSA_RS10040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HALSA_RS10050	COG1098	S1 RNA binding domain
HALSA_RS10060	COG2183	response to ionizing radiation
HALSA_RS10095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HALSA_RS10100	COG3842	ATPase activity
HALSA_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HALSA_RS10120	COG1120	ATPase activity
HALSA_RS10125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALSA_RS10135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HALSA_RS10225	COG1686	Belongs to the peptidase S11 family
HALSA_RS10230	COG3956	TIGRFAM MazG family protein
HALSA_RS10235	COG2244	polysaccharide biosynthetic process
HALSA_RS10240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HALSA_RS10245	COG0193	aminoacyl-tRNA hydrolase activity
HALSA_RS10250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HALSA_RS10260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HALSA_RS10265	COG2088	sporulation resulting in formation of a cellular spore
HALSA_RS10285	COG0789	Transcriptional regulator
HALSA_RS10290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HALSA_RS10295	COG1268	BioY protein
HALSA_RS10305	COG1983	PspC domain protein
HALSA_RS10310	COG1132	(ABC) transporter
HALSA_RS10315	COG0704	Plays a role in the regulation of phosphate uptake
HALSA_RS10320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HALSA_RS10325	COG0581	inorganic phosphate transmembrane transporter activity
HALSA_RS10330	COG0573	inorganic phosphate transmembrane transporter activity
HALSA_RS10340	COG5002	protein histidine kinase activity
HALSA_RS10345	COG0745	RESPONSE REGULATOR receiver
HALSA_RS10355	COG4466	Protein conserved in bacteria
HALSA_RS10365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HALSA_RS10370	COG0673	inositol 2-dehydrogenase activity
HALSA_RS10375	COG0084	hydrolase, TatD family'
HALSA_RS10385	COG0301	tRNA thio-modification
HALSA_RS10390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HALSA_RS10400	COG1475	DNA binding
HALSA_RS10405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HALSA_RS10410	COG2827	Endonuclease containing a URI domain
HALSA_RS10425	COG0497	DNA recombination
HALSA_RS10440	COG1464	Belongs to the NlpA lipoprotein family
HALSA_RS10445	COG2011	ABC-type metal ion transport system permease component
HALSA_RS10450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HALSA_RS10475	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HALSA_RS10505	COG0473	3-isopropylmalate dehydrogenase activity
HALSA_RS10510	COG0613	PHP domain protein
HALSA_RS10540	COG0747	negative chemotaxis
HALSA_RS10545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS10560	COG2897	thiosulfate sulfurtransferase activity
HALSA_RS10575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HALSA_RS10580	COG0822	iron-sulfur transferase activity
HALSA_RS10585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HALSA_RS10590	COG0719	Fe-S assembly protein
HALSA_RS10595	COG0719	Fe-S assembly protein
HALSA_RS10605	COG0628	permease
HALSA_RS10610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HALSA_RS10630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HALSA_RS10635	COG3842	ATPase activity
HALSA_RS10640	COG1178	ABC-type Fe3 transport system permease component
HALSA_RS10645	COG1840	ABC-type Fe3 transport system, periplasmic component
HALSA_RS10650	COG1307	EDD domain protein, DegV family
HALSA_RS10680	COG4303	Ethanolamine ammonia lyase large subunit
HALSA_RS10685	COG4303	Ethanolamine ammonia lyase large subunit
HALSA_RS10700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HALSA_RS10705	COG1757	Na H antiporter
HALSA_RS10715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HALSA_RS10720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HALSA_RS10725	COG0321	lipoyl(octanoyl) transferase activity
HALSA_RS10740	COG0436	Aminotransferase
HALSA_RS10750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HALSA_RS10755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HALSA_RS10760	COG2252	PERMEase
HALSA_RS10765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HALSA_RS10770	COG0167	dihydroorotate dehydrogenase activity
HALSA_RS10800	COG0402	S-adenosylhomocysteine deaminase activity
HALSA_RS10820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HALSA_RS10825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HALSA_RS10830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALSA_RS10840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALSA_RS10855	COG1342	Belongs to the UPF0251 family
HALSA_RS10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALSA_RS10865	COG3681	Belongs to the UPF0597 family
HALSA_RS10885	COG2814	Major facilitator Superfamily
HALSA_RS10915	COG0438	transferase activity, transferring glycosyl groups
HALSA_RS10925	COG0859	PFAM glycosyl transferase family 9
HALSA_RS10930	COG0859	PFAM glycosyl transferase family 9
HALSA_RS10940	COG1560	Kdo2-lipid A biosynthetic process
HALSA_RS10950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HALSA_RS10960	COG1663	tetraacyldisaccharide 4'-kinase activity
HALSA_RS10970	COG1132	(ABC) transporter
HALSA_RS10980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HALSA_RS10985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HALSA_RS10995	COG0166	Belongs to the GPI family
HALSA_RS11010	COG0747	negative chemotaxis
HALSA_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS11030	COG1217	gtp-binding protein TYPA
HALSA_RS11035	COG1278	Cold shock
HALSA_RS11040	COG1278	Cold shock
HALSA_RS11045	COG0159	tryptophan synthase activity
HALSA_RS11050	COG0133	tryptophan synthase activity
HALSA_RS11055	COG0135	phosphoribosylanthranilate isomerase activity
HALSA_RS11060	COG0134	indole-3-glycerol-phosphate synthase activity
HALSA_RS11065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALSA_RS11070	COG0512	Glutamine amidotransferase of anthranilate synthase
HALSA_RS11070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALSA_RS11075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HALSA_RS11095	COG1554	hydrolase, family 65, central catalytic
HALSA_RS11105	COG1956	GAF domain-containing protein
HALSA_RS11110	COG2431	L-lysine efflux transmembrane transporter activity
HALSA_RS11120	COG0071	Belongs to the small heat shock protein (HSP20) family
HALSA_RS11125	COG1067	ATP-dependent peptidase activity
HALSA_RS11140	COG1136	(ABC) transporter
HALSA_RS11145	COG4662	Binding-protein-dependent transport system inner membrane component
HALSA_RS11155	COG0366	Alpha amylase catalytic
HALSA_RS11160	COG1609	Transcriptional regulator
HALSA_RS11175	COG1653	transport
HALSA_RS11185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HALSA_RS11195	COG1120	ATPase activity
HALSA_RS11200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALSA_RS11205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HALSA_RS11215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HALSA_RS11225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HALSA_RS11230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALSA_RS11245	COG1797	cobyrinic acid a,c-diamide synthase activity
HALSA_RS11285	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HALSA_RS11295	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HALSA_RS11300	COG1492	cobalamin metabolic process
HALSA_RS11305	COG1492	cobalamin metabolic process
HALSA_RS11325	COG1121	(ABC) transporter
HALSA_RS11330	COG4139	cobalamin transport
HALSA_RS11340	COG0864	Transcriptional regulator
HALSA_RS11350	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HALSA_RS11355	COG1691	(AIR) carboxylase
HALSA_RS11360	COG1606	tRNA processing
HALSA_RS11380	COG0704	Plays a role in the regulation of phosphate uptake
HALSA_RS11395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HALSA_RS11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALSA_RS11405	COG0601	transmembrane transport
HALSA_RS11410	COG0747	negative chemotaxis
HALSA_RS11415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HALSA_RS11430	COG1120	ATPase activity
HALSA_RS11435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALSA_RS11440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HALSA_RS11460	COG1278	Cold shock
HALSA_RS11475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HALSA_RS11475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HALSA_RS11485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS11495	COG3328	transposase activity
HALSA_RS11505	COG0138	bifunctional purine biosynthesis protein purh
HALSA_RS11510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HALSA_RS11515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HALSA_RS11520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HALSA_RS11530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HALSA_RS11535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HALSA_RS11540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HALSA_RS11545	COG0151	Belongs to the GarS family
HALSA_RS11550	COG2133	pyrroloquinoline quinone binding
HALSA_RS11565	COG3344	reverse transcriptase
HALSA_RS11575	COG4191	Histidine kinase
HALSA_RS11585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HALSA_RS11585	COG0140	phosphoribosyl-ATP diphosphatase activity
HALSA_RS11600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HALSA_RS11605	COG0131	Imidazoleglycerol-phosphate dehydratase
HALSA_RS11610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALSA_RS11615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HALSA_RS11620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HALSA_RS11625	COG0124	histidyl-tRNA synthetase
HALSA_RS11630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HALSA_RS11650	COG0395	ABC-type sugar transport system, permease component
HALSA_RS11655	COG1175	transmembrane transport
HALSA_RS11660	COG1653	transport
HALSA_RS11665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HALSA_RS11670	COG2271	Major facilitator Superfamily
HALSA_RS11680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HALSA_RS11685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HALSA_RS11685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS11685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HALSA_RS11700	COG2239	Acts as a magnesium transporter
HALSA_RS11705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HALSA_RS11710	COG0095	Lipoate-protein ligase
HALSA_RS11725	COG3732	PTS system glucitol sorbitol-specific
HALSA_RS11730	COG3730	PTS system glucitol sorbitol-specific
HALSA_RS11740	COG2390	Transcriptional regulator
HALSA_RS11745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HALSA_RS11750	COG0022	dehydrogenase e1 component
HALSA_RS11755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALSA_RS11770	COG0737	Belongs to the 5'-nucleotidase family
HALSA_RS11780	COG2376	Dihydroxyacetone kinase
HALSA_RS11785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HALSA_RS11800	COG2226	methyltransferase
HALSA_RS11805	COG0398	Pfam SNARE associated Golgi protein
HALSA_RS11820	COG2391	methyltransferase activity
HALSA_RS11895	COG2002	toxin-antitoxin pair type II binding
HALSA_RS11905	COG2801	Transposase and inactivated derivatives
HALSA_RS11930	COG1285	pathogenesis
HALSA_RS11935	COG2199	diguanylate cyclase activity
HALSA_RS11935	COG2203	Gaf domain
HALSA_RS11945	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALSA_RS11945	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALSA_RS11945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALSA_RS11945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HALSA_RS11985	COG1950	PFAM Membrane protein of
HALSA_RS11990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALSA_RS11995	COG1045	serine acetyltransferase
HALSA_RS12005	COG0151	Belongs to the GarS family
HALSA_RS12010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HALSA_RS12015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HALSA_RS12030	COG0305	Participates in initiation and elongation during chromosome replication
HALSA_RS12060	COG0577	efflux transmembrane transporter activity
HALSA_RS12065	COG1136	(ABC) transporter
HALSA_RS12065	COG0577	efflux transmembrane transporter activity
HALSA_RS12070	COG1136	(ABC) transporter
HALSA_RS12080	COG0673	inositol 2-dehydrogenase activity
HALSA_RS12085	COG0589	response to stress
HALSA_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
HALSA_RS12105	COG1312	Catalyzes the dehydration of D-mannonate
HALSA_RS12110	COG0359	binds to the 23S rRNA
HALSA_RS12120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HALSA_RS12125	COG0629	single-stranded DNA binding
HALSA_RS12130	COG0360	Binds together with S18 to 16S ribosomal RNA
HALSA_RS12140	COG0012	GTP binding
HALSA_RS12145	COG4481	Protein conserved in bacteria
HALSA_RS12155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALSA_RS12160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALSA_RS12165	COG0509	glycine decarboxylation via glycine cleavage system
HALSA_RS12170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HALSA_RS12180	COG1475	DNA binding
HALSA_RS12185	COG1192	Involved in chromosome partitioning
HALSA_RS12195	COG0357	Ribosomal RNA small subunit methyltransferase G
HALSA_RS12200	COG0445	tRNA wobble uridine modification
HALSA_RS12205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HALSA_RS12210	COG1847	R3H domain protein
HALSA_RS12215	COG0706	membrane insertase activity
HALSA_RS12250	COG0561	phosphatase activity
HALSA_RS12260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12260	COG2199	diguanylate cyclase activity
HALSA_RS12265	COG2199	diguanylate cyclase activity
HALSA_RS12265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12295	COG2199	diguanylate cyclase activity
HALSA_RS12295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12305	COG5002	protein histidine kinase activity
HALSA_RS12305	COG5001	Diguanylate cyclase
HALSA_RS12305	COG3447	MASE1 domain protein
HALSA_RS12325	COG0784	Response regulator, receiver
HALSA_RS12325	COG3437	response regulator, receiver
HALSA_RS12340	COG3706	GGDEF domain
HALSA_RS12345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12345	COG2199	diguanylate cyclase activity
HALSA_RS12365	COG2801	Transposase and inactivated derivatives
HALSA_RS12370	COG2390	Transcriptional regulator
HALSA_RS12380	COG2199	diguanylate cyclase activity
HALSA_RS12380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12390	COG0791	NLP P60 protein
HALSA_RS12390	COG1388	LysM domain
HALSA_RS12405	COG1309	transcriptional regulator
HALSA_RS12410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALSA_RS12425	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HALSA_RS12430	COG2211	Major facilitator Superfamily
HALSA_RS12470	COG1285	pathogenesis
HALSA_RS12495	COG3706	GGDEF domain
HALSA_RS12505	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HALSA_RS12535	COG0671	phosphoesterase, PA-phosphatase related