locus-tag	class	description
EY643_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EY643_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EY643_RS00050	COG0751	glycine-tRNA ligase activity
EY643_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
EY643_RS00065	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EY643_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EY643_RS00075	COG0569	domain protein
EY643_RS00085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EY643_RS00090	COG0242	peptide deformylase activity
EY643_RS00100	COG0758	DNA mediated transformation
EY643_RS00110	COG0408	coproporphyrinogen oxidase activity
EY643_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EY643_RS00120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EY643_RS00135	COG0534	Mate efflux family protein
EY643_RS00140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EY643_RS00145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EY643_RS00150	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EY643_RS00175	COG0109	protoheme IX farnesyltransferase activity
EY643_RS00190	COG3228	Belongs to the MtfA family
EY643_RS00195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EY643_RS00215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EY643_RS00220	COG2814	Major facilitator Superfamily
EY643_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS00235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EY643_RS00240	COG1115	amino acid carrier protein
EY643_RS00245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EY643_RS00255	COG0129	dihydroxy-acid dehydratase activity
EY643_RS00270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EY643_RS00270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EY643_RS00280	COG0306	phosphate transporter
EY643_RS00285	COG1392	Phosphate transport regulator
EY643_RS00290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EY643_RS00300	COG0859	PFAM glycosyl transferase family 9
EY643_RS00305	COG0859	PFAM glycosyl transferase family 9
EY643_RS00310	COG0438	transferase activity, transferring glycosyl groups
EY643_RS00345	COG1088	dTDP-glucose 4,6-dehydratase activity
EY643_RS00360	COG0438	transferase activity, transferring glycosyl groups
EY643_RS00380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EY643_RS00380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EY643_RS00395	COG1519	Transferase
EY643_RS00400	COG1538	Outer membrane efflux protein
EY643_RS00410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EY643_RS00425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS00430	COG0431	NADPH-dependent FMN reductase
EY643_RS00435	COG0798	PFAM Bile acid sodium symporter
EY643_RS00445	COG0640	Transcriptional regulator
EY643_RS00455	COG2095	MarC family integral membrane protein
EY643_RS00460	COG2226	methyltransferase
EY643_RS00475	COG2226	methyltransferase
EY643_RS00505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EY643_RS00515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EY643_RS00520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EY643_RS00535	COG1040	competence protein
EY643_RS00540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EY643_RS00545	COG0156	8-amino-7-oxononanoate synthase activity
EY643_RS00550	COG2226	methyltransferase
EY643_RS00550	COG1073	alpha beta
EY643_RS00555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EY643_RS00560	COG1960	acyl-CoA dehydrogenase activity
EY643_RS00590	COG1022	Amp-dependent synthetase and ligase
EY643_RS00595	COG1509	lysine 2,3-aminomutase activity
EY643_RS00600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EY643_RS00615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EY643_RS00625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EY643_RS00630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EY643_RS00660	COG0714	Associated with various cellular activities
EY643_RS00670	COG5001	Diguanylate cyclase
EY643_RS00680	COG0179	Fumarylacetoacetate (FAA) hydrolase
EY643_RS00730	COG0402	S-adenosylhomocysteine deaminase activity
EY643_RS00750	COG0243	molybdopterin cofactor binding
EY643_RS00755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EY643_RS00760	COG1116	anion transmembrane transporter activity
EY643_RS00765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EY643_RS00770	COG1116	anion transmembrane transporter activity
EY643_RS00770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EY643_RS00775	COG1116	anion transmembrane transporter activity
EY643_RS00775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EY643_RS00780	COG3707	response regulator
EY643_RS00790	COG4771	TonB-dependent receptor
EY643_RS00805	COG0515	serine threonine protein kinase
EY643_RS00810	COG2223	nitrite transmembrane transporter activity
EY643_RS00815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EY643_RS00815	COG2146	nitrite reductase [NAD(P)H] activity
EY643_RS00830	COG0628	permease
EY643_RS00840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EY643_RS00870	COG4771	TonB-dependent receptor
EY643_RS00875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EY643_RS00890	COG0463	Glycosyl transferase, family 2
EY643_RS00920	COG1134	teichoic acid transport
EY643_RS00990	COG3122	Protein conserved in bacteria
EY643_RS01000	COG0076	glutamate decarboxylase activity
EY643_RS01015	COG3706	GGDEF domain
EY643_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS01025	COG1215	transferase activity, transferring glycosyl groups
EY643_RS01035	COG3240	lipase activity
EY643_RS01055	COG2311	Membrane
EY643_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EY643_RS01105	COG3804	dihydrodipicolinate reductase
EY643_RS01110	COG4771	TonB-dependent receptor
EY643_RS01140	COG0702	epimerase
EY643_RS01150	COG3119	arylsulfatase activity
EY643_RS01170	COG2204	response regulator
EY643_RS01175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EY643_RS01180	COG2124	cytochrome p450
EY643_RS01185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EY643_RS01200	COG2366	antibiotic biosynthetic process
EY643_RS01225	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EY643_RS01230	COG4774	siderophore transport
EY643_RS01245	COG0154	amidase activity
EY643_RS01250	COG0415	Belongs to the DNA photolyase family
EY643_RS01275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EY643_RS01280	COG3119	arylsulfatase activity
EY643_RS01285	COG2211	Major facilitator Superfamily
EY643_RS01310	COG3530	Putative quorum-sensing-regulated virulence factor
EY643_RS01325	COG0028	Belongs to the TPP enzyme family
EY643_RS01370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EY643_RS01405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EY643_RS01430	COG4067	protein conserved in archaea
EY643_RS01430	COG0189	ligase activity
EY643_RS01435	COG0189	ligase activity
EY643_RS01435	COG0569	domain protein
EY643_RS01460	COG1506	peptidase
EY643_RS01460	COG0823	Involved in the tonB-independent uptake of proteins
EY643_RS01460	COG4946	Tricorn protease homolog
EY643_RS01465	COG3408	Glycogen debranching enzyme
EY643_RS01465	COG3119	arylsulfatase activity
EY643_RS01595	COG1253	flavin adenine dinucleotide binding
EY643_RS01600	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EY643_RS01625	COG1610	YqeY-like protein
EY643_RS01630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EY643_RS01635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EY643_RS01640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EY643_RS01650	COG0617	tRNA 3'-terminal CCA addition
EY643_RS01655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EY643_RS01660	COG2967	ApaG domain
EY643_RS01665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EY643_RS01700	COG3562	capsule polysaccharide
EY643_RS01705	COG0438	transferase activity, transferring glycosyl groups
EY643_RS01765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EY643_RS01770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EY643_RS01775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EY643_RS01780	COG3178	'Phosphotransferase
EY643_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EY643_RS01800	COG0512	Glutamine amidotransferase of anthranilate synthase
EY643_RS01805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EY643_RS01810	COG0134	indole-3-glycerol-phosphate synthase activity
EY643_RS01820	COG1765	OsmC-like protein
EY643_RS01830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EY643_RS01835	COG0151	Belongs to the GarS family
EY643_RS01840	COG0138	bifunctional purine biosynthesis protein purh
EY643_RS01855	COG2264	protein methyltransferase activity
EY643_RS01870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EY643_RS01875	COG4232	protein-disulfide reductase activity
EY643_RS01895	COG0417	DNA replication proofreading
EY643_RS01900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EY643_RS01905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EY643_RS01915	COG1119	ATPase activity
EY643_RS01935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EY643_RS01950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EY643_RS01965	COG0316	Belongs to the HesB IscA family
EY643_RS01980	COG0739	heme binding
EY643_RS02020	COG1752	Esterase of the alpha-beta hydrolase superfamily
EY643_RS02025	COG3128	pkhd-type hydroxylase
EY643_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS02050	COG1611	Belongs to the LOG family
EY643_RS02055	COG2183	response to ionizing radiation
EY643_RS02075	COG1301	dicarboxylic acid transport
EY643_RS02080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EY643_RS02090	COG1228	amidohydrolase
EY643_RS02095	COG4783	chaperone-mediated protein folding
EY643_RS02135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EY643_RS02205	COG0545	Peptidyl-prolyl cis-trans isomerase
EY643_RS02210	COG0489	protein tyrosine kinase activity
EY643_RS02215	COG0175	sulfate reduction
EY643_RS02240	COG0017	Asparaginyl-tRNA synthetase
EY643_RS02250	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EY643_RS02255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EY643_RS02265	COG0688	phosphatidylethanolamine metabolic process
EY643_RS02285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EY643_RS02285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EY643_RS02290	COG0802	atpase or kinase
EY643_RS02295	COG0860	N-Acetylmuramoyl-L-alanine amidase
EY643_RS02300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EY643_RS02305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EY643_RS02310	COG1923	regulation of RNA biosynthetic process
EY643_RS02315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EY643_RS02320	COG0330	HflC and HflK could
EY643_RS02325	COG0330	HflC and HflK could
EY643_RS02335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EY643_RS02405	COG0367	asparagine synthase
EY643_RS02420	COG1132	(ABC) transporter
EY643_RS02490	COG2244	polysaccharide biosynthetic process
EY643_RS02510	COG0438	transferase activity, transferring glycosyl groups
EY643_RS02515	COG0673	inositol 2-dehydrogenase activity
EY643_RS02550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EY643_RS02555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EY643_RS02560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EY643_RS02575	COG0489	protein tyrosine kinase activity
EY643_RS02580	COG0484	heat shock protein binding
EY643_RS02595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EY643_RS02620	COG4464	protein tyrosine phosphatase activity
EY643_RS02630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EY643_RS02640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EY643_RS02665	COG0501	Belongs to the peptidase M48B family
EY643_RS02670	COG1704	LemA family
EY643_RS02680	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EY643_RS02710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EY643_RS02715	COG0557	exoribonuclease II activity
EY643_RS02720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EY643_RS02725	COG0360	Binds together with S18 to 16S ribosomal RNA
EY643_RS02770	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EY643_RS02785	COG0488	(ABC) transporter
EY643_RS02795	COG2307	Protein conserved in bacteria
EY643_RS02795	COG2308	Evidence 4 Homologs of previously reported genes of
EY643_RS02810	COG2308	Evidence 4 Homologs of previously reported genes of
EY643_RS02815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EY643_RS02820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EY643_RS02825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EY643_RS02825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EY643_RS02840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EY643_RS02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EY643_RS02855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EY643_RS02865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EY643_RS02875	COG1722	exodeoxyribonuclease VII activity
EY643_RS02900	COG0463	Glycosyl transferase, family 2
EY643_RS02935	COG0297	glycogen (starch) synthase activity
EY643_RS02940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EY643_RS02945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EY643_RS02955	COG4251	negative regulation of phosphorylation
EY643_RS02955	COG3706	GGDEF domain
EY643_RS02955	COG2203	Gaf domain
EY643_RS02955	COG5001	Diguanylate cyclase
EY643_RS02960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EY643_RS02965	COG1011	Hydrolase
EY643_RS02980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EY643_RS02985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EY643_RS03005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EY643_RS03005	COG0475	glutathione-regulated potassium exporter activity
EY643_RS03020	COG4770	biotin carboxylase activity
EY643_RS03025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EY643_RS03030	COG1960	acyl-CoA dehydrogenase activity
EY643_RS03035	COG0789	Transcriptional regulator
EY643_RS03040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EY643_RS03040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EY643_RS03045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EY643_RS03050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EY643_RS03050	COG2755	lipolytic protein G-D-S-L family
EY643_RS03100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EY643_RS03120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EY643_RS03125	COG0081	regulation of translation
EY643_RS03130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EY643_RS03135	COG0222	ribosome binding
EY643_RS03140	COG0085	RNA polymerase activity
EY643_RS03145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EY643_RS03155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EY643_RS03170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EY643_RS03175	COG0049	tRNA binding
EY643_RS03180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EY643_RS03185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EY643_RS03210	COG0386	Belongs to the glutathione peroxidase family
EY643_RS03235	COG0174	glutamine synthetase
EY643_RS03245	COG2207	Transcriptional regulator
EY643_RS03245	COG4753	response regulator
EY643_RS03250	COG0741	lytic transglycosylase activity
EY643_RS03255	COG0442	prolyl-tRNA aminoacylation
EY643_RS03270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EY643_RS03275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EY643_RS03280	COG0632	four-way junction helicase activity
EY643_RS03285	COG2255	four-way junction helicase activity
EY643_RS03290	COG0824	Thioesterase
EY643_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
EY643_RS03315	COG2885	chlorophyll binding
EY643_RS03320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EY643_RS03325	COG0602	queuosine metabolic process
EY643_RS03330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EY643_RS03365	COG3119	arylsulfatase activity
EY643_RS03385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EY643_RS03395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EY643_RS03415	COG4771	TonB-dependent receptor
EY643_RS03435	COG4638	Rieske (2fe-2S)
EY643_RS03440	COG1454	alcohol dehydrogenase
EY643_RS03445	COG0824	Thioesterase
EY643_RS03465	COG0505	Belongs to the CarA family
EY643_RS03475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EY643_RS03525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EY643_RS03530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EY643_RS03535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EY643_RS03540	COG0149	triose-phosphate isomerase activity
EY643_RS03545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EY643_RS03555	COG0604	alcohol dehydrogenase
EY643_RS03565	COG0779	Required for maturation of 30S ribosomal subunits
EY643_RS03570	COG0195	Participates in both transcription termination and antitermination
EY643_RS03575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EY643_RS03580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EY643_RS03585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EY643_RS03590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EY643_RS03595	COG1185	polyribonucleotide nucleotidyltransferase activity
EY643_RS03600	COG0653	protein targeting
EY643_RS03605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EY643_RS03615	COG0193	aminoacyl-tRNA hydrolase activity
EY643_RS03620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EY643_RS03625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EY643_RS03635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EY643_RS03640	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EY643_RS03655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EY643_RS03665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EY643_RS03695	COG2840	Smr protein MutS2
EY643_RS03700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EY643_RS03705	COG0436	Aminotransferase
EY643_RS03715	COG0024	Methionine aminopeptidase
EY643_RS03720	COG0052	Belongs to the universal ribosomal protein uS2 family
EY643_RS03725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EY643_RS03735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EY643_RS03735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EY643_RS03740	COG2925	Exonuclease
EY643_RS03745	COG0540	Belongs to the ATCase OTCase family
EY643_RS03750	COG0494	nUDIX hydrolase
EY643_RS03755	COG0728	peptidoglycan biosynthetic process
EY643_RS03760	COG0196	riboflavin kinase activity
EY643_RS03765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EY643_RS03770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EY643_RS03775	COG1047	Peptidyl-prolyl cis-trans
EY643_RS03780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EY643_RS03810	COG4968	Prepilin-type N-terminal cleavage methylation domain
EY643_RS03820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EY643_RS03820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EY643_RS03850	COG0028	Belongs to the TPP enzyme family
EY643_RS03865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EY643_RS03875	COG1183	phosphatidylcholine synthase activity
EY643_RS03890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EY643_RS03935	COG1752	Esterase of the alpha-beta hydrolase superfamily
EY643_RS03945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EY643_RS03975	COG4660	Part of a membrane complex involved in electron transport
EY643_RS03980	COG4659	FMN binding
EY643_RS03985	COG4658	electron transport chain
EY643_RS03995	COG2878	Part of a membrane complex involved in electron transport
EY643_RS04000	COG4657	Part of a membrane complex involved in electron transport
EY643_RS04005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EY643_RS04005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EY643_RS04010	COG0489	protein tyrosine kinase activity
EY643_RS04015	COG0717	Belongs to the dCTP deaminase family
EY643_RS04025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EY643_RS04030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EY643_RS04040	COG0628	permease
EY643_RS04045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EY643_RS04060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EY643_RS04065	COG0436	Aminotransferase
EY643_RS04070	COG1522	sequence-specific DNA binding
EY643_RS04115	COG4221	oxidoreductase activity
EY643_RS04125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EY643_RS04135	COG0339	signal peptide processing
EY643_RS04145	COG0513	Belongs to the DEAD box helicase family
EY643_RS04160	COG3202	ADP transmembrane transporter activity
EY643_RS04170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EY643_RS04185	COG1295	ribonuclease BN
EY643_RS04190	COG1393	Belongs to the ArsC family
EY643_RS04205	COG0616	signal peptide processing
EY643_RS04225	COG0668	transmembrane transport
EY643_RS04260	COG4771	TonB-dependent receptor
EY643_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS04275	COG3008	intermembrane lipid transfer
EY643_RS04275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EY643_RS04280	COG1127	ABC transporter
EY643_RS04285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EY643_RS04295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EY643_RS04300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EY643_RS04305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EY643_RS04325	COG0742	ribosomal rna small subunit methyltransferase
EY643_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EY643_RS04340	COG2171	N-acyltransferase activity
EY643_RS04345	COG1393	Belongs to the ArsC family
EY643_RS04365	COG0154	amidase activity
EY643_RS04370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EY643_RS04375	COG1077	Cell shape determining protein MreB Mrl
EY643_RS04380	COG1792	Involved in formation and maintenance of cell shape
EY643_RS04385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EY643_RS04390	COG0424	maF-like protein
EY643_RS04395	COG1530	ribonuclease E activity
EY643_RS04405	COG3028	Belongs to the UPF0307 family
EY643_RS04410	COG2239	Acts as a magnesium transporter
EY643_RS04415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EY643_RS04420	COG1660	Displays ATPase and GTPase activities
EY643_RS04440	COG1137	ATPase activity
EY643_RS04455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EY643_RS04475	COG5007	Belongs to the BolA IbaG family
EY643_RS04480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EY643_RS04485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EY643_RS04510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EY643_RS04515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EY643_RS04520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EY643_RS04525	COG0723	plastoquinol--plastocyanin reductase activity
EY643_RS04530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EY643_RS04535	COG0625	glutathione transferase activity
EY643_RS04540	COG2969	positive regulation of protein catabolic process
EY643_RS04545	COG2823	Periplasmic or secreted lipoprotein
EY643_RS04555	COG0792	nuclease activity
EY643_RS04575	COG2001	Belongs to the MraZ family
EY643_RS04580	COG0275	rRNA processing
EY643_RS04595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EY643_RS04600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EY643_RS04605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EY643_RS04615	COG0772	Belongs to the SEDS family
EY643_RS04620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EY643_RS04625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EY643_RS04630	COG1181	Belongs to the D-alanine--D-alanine ligase family
EY643_RS04650	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EY643_RS04655	COG0739	heme binding
EY643_RS04660	COG0653	protein targeting
EY643_RS04665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EY643_RS04670	COG0494	nUDIX hydrolase
EY643_RS04675	COG0237	dephospho-CoA kinase activity
EY643_RS04710	COG0463	Glycosyl transferase, family 2
EY643_RS04725	COG1960	acyl-CoA dehydrogenase activity
EY643_RS04730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EY643_RS04740	COG3023	N-Acetylmuramoyl-L-alanine amidase
EY643_RS04775	COG0288	reversible hydration of carbon dioxide
EY643_RS04780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EY643_RS04820	COG2165	general secretion pathway protein
EY643_RS04850	COG1773	rubredoxin
EY643_RS04855	COG0006	proline dipeptidase activity
EY643_RS04860	COG0733	neurotransmitter:sodium symporter activity
EY643_RS04865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS04870	COG2365	Tyrosine phosphatase family
EY643_RS04875	COG2204	response regulator
EY643_RS04890	COG0643	Histidine kinase
EY643_RS04890	COG2198	Histidine kinase
EY643_RS04895	COG2198	Histidine kinase
EY643_RS04895	COG0784	Response regulator, receiver
EY643_RS04895	COG0643	Histidine kinase
EY643_RS04925	COG1960	acyl-CoA dehydrogenase activity
EY643_RS04930	COG1960	acyl-CoA dehydrogenase activity
EY643_RS04935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EY643_RS04950	COG0501	Belongs to the peptidase M48B family
EY643_RS04975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EY643_RS04990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EY643_RS04995	COG0508	dehydrogenase complex catalyzes the overall conversion of
EY643_RS05000	COG0022	dehydrogenase e1 component
EY643_RS05005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EY643_RS05015	COG1024	Enoyl-CoA hydratase
EY643_RS05035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EY643_RS05050	COG0784	Response regulator, receiver
EY643_RS05060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EY643_RS05065	COG1570	exodeoxyribonuclease VII activity
EY643_RS05075	COG0519	Catalyzes the synthesis of GMP from XMP
EY643_RS05075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EY643_RS05100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EY643_RS05115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EY643_RS05135	COG1104	cysteine desulfurase activity
EY643_RS05145	COG0316	Belongs to the HesB IscA family
EY643_RS05150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EY643_RS05155	COG0443	Heat shock 70 kDa protein
EY643_RS05170	COG0105	UTP biosynthetic process
EY643_RS05175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EY643_RS05190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EY643_RS05200	COG2976	Protein conserved in bacteria
EY643_RS05210	COG1160	GTP binding
EY643_RS05215	COG2346	COG2346, Truncated hemoglobins
EY643_RS05240	COG1131	(ABC) transporter
EY643_RS05250	COG1914	H( )-stimulated, divalent metal cation uptake system
EY643_RS05280	COG4221	oxidoreductase activity
EY643_RS05295	COG3264	Mechanosensitive ion channel
EY643_RS05295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EY643_RS05300	COG0598	Magnesium transport protein CorA
EY643_RS05310	COG2132	Multicopper oxidase
EY643_RS05320	COG0745	RESPONSE REGULATOR receiver
EY643_RS05325	COG5002	protein histidine kinase activity
EY643_RS05325	COG5000	phosphorelay sensor kinase activity
EY643_RS05420	COG4638	Rieske (2fe-2S)
EY643_RS05425	COG1960	acyl-CoA dehydrogenase activity
EY643_RS05435	COG1063	alcohol dehydrogenase
EY643_RS05475	COG0412	Dienelactone hydrolase
EY643_RS05485	COG1960	acyl-CoA dehydrogenase activity
EY643_RS05490	COG1309	transcriptional regulator
EY643_RS05510	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EY643_RS05520	COG0183	Belongs to the thiolase family
EY643_RS05525	COG4638	Rieske (2fe-2S)
EY643_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS05610	COG4221	oxidoreductase activity
EY643_RS05640	COG1012	belongs to the aldehyde dehydrogenase family
EY643_RS05645	COG1960	acyl-CoA dehydrogenase activity
EY643_RS05650	COG1024	Enoyl-CoA hydratase
EY643_RS05655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EY643_RS05665	COG0596	Alpha beta hydrolase
EY643_RS05680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EY643_RS05690	COG2186	Transcriptional regulator
EY643_RS05705	COG2186	Transcriptional regulator
EY643_RS05720	COG2271	Major facilitator Superfamily
EY643_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS05730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EY643_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS05790	COG1960	acyl-CoA dehydrogenase activity
EY643_RS05795	COG0318	PFAM AMP-dependent synthetase and ligase
EY643_RS05810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EY643_RS05840	COG4771	TonB-dependent receptor
EY643_RS05850	COG2814	Major facilitator Superfamily
EY643_RS05855	COG4935	Belongs to the peptidase S8 family
EY643_RS05855	COG2234	aminopeptidase activity
EY643_RS05920	COG0514	ATP-dependent DNA helicase (RecQ)
EY643_RS05945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EY643_RS05955	COG0517	IMP dehydrogenase activity
EY643_RS05990	COG1902	pentaerythritol trinitrate reductase activity
EY643_RS05990	COG0446	pyridine nucleotide-disulphide oxidoreductase
EY643_RS05995	COG1695	Transcriptional regulator
EY643_RS06025	COG0457	Tetratricopeptide repeat
EY643_RS06035	COG1960	acyl-CoA dehydrogenase activity
EY643_RS06040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EY643_RS06050	COG0697	spore germination
EY643_RS06055	COG4783	chaperone-mediated protein folding
EY643_RS06060	COG3409	Peptidoglycan-binding domain 1 protein
EY643_RS06060	COG3267	Type II secretory pathway component ExeA
EY643_RS06070	COG1785	Belongs to the alkaline phosphatase family
EY643_RS06080	COG0004	ammonium transporteR
EY643_RS06095	COG2267	carboxylic ester hydrolase activity
EY643_RS06100	COG0248	Ppx GppA phosphatase
EY643_RS06120	COG1984	allophanate hydrolase subunit 2
EY643_RS06130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EY643_RS06135	COG4336	lyase activity
EY643_RS06140	COG1946	Acyl-CoA thioesterase
EY643_RS06150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EY643_RS06165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EY643_RS06165	COG0617	tRNA 3'-terminal CCA addition
EY643_RS06165	COG0517	IMP dehydrogenase activity
EY643_RS06175	COG0628	permease
EY643_RS06185	COG1566	PFAM secretion protein HlyD family protein
EY643_RS06210	COG1024	Enoyl-CoA hydratase
EY643_RS06210	COG1250	3-hydroxyacyl-CoA dehydrogenase
EY643_RS06215	COG0183	Belongs to the thiolase family
EY643_RS06230	COG0596	Alpha beta hydrolase
EY643_RS06235	COG0183	Belongs to the thiolase family
EY643_RS06240	COG1024	Enoyl-CoA hydratase
EY643_RS06250	COG3091	SprT-like family
EY643_RS06265	COG3706	GGDEF domain
EY643_RS06270	COG1960	acyl-CoA dehydrogenase activity
EY643_RS06280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EY643_RS06285	COG1024	Enoyl-CoA hydratase
EY643_RS06340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EY643_RS06345	COG0084	hydrolase, TatD family'
EY643_RS06350	COG0583	DNA-binding transcription factor activity
EY643_RS06375	COG3104	oligopeptide transport
EY643_RS06385	COG0028	Belongs to the TPP enzyme family
EY643_RS06400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EY643_RS06405	COG3630	sodium ion export across plasma membrane
EY643_RS06410	COG5016	pyruvate
EY643_RS06410	COG0511	ligase activity, forming carbon-carbon bonds
EY643_RS06415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EY643_RS06440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EY643_RS06450	COG2350	Protein conserved in bacteria
EY643_RS06455	COG2917	probably involved in intracellular septation
EY643_RS06460	COG0613	PHP domain protein
EY643_RS06465	COG0009	L-threonylcarbamoyladenylate synthase
EY643_RS06475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EY643_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS06495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EY643_RS06500	COG0402	S-adenosylhomocysteine deaminase activity
EY643_RS06510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EY643_RS06515	COG0077	Prephenate dehydratase
EY643_RS06515	COG1605	Chorismate mutase
EY643_RS06525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EY643_RS06530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EY643_RS06550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EY643_RS06555	COG0284	orotidine-5'-phosphate decarboxylase activity
EY643_RS06560	COG1555	photosystem II stabilization
EY643_RS06565	COG1090	epimerase
EY643_RS06570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EY643_RS06585	COG1454	alcohol dehydrogenase
EY643_RS06595	COG1403	HNH endonuclease
EY643_RS06605	COG3655	Transcriptional regulator
EY643_RS06650	COG0556	nucleotide-excision repair
EY643_RS06660	COG3119	arylsulfatase activity
EY643_RS06665	COG2205	protein histidine kinase activity
EY643_RS06670	COG0745	RESPONSE REGULATOR receiver
EY643_RS06675	COG2304	oxidoreductase activity
EY643_RS06685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EY643_RS06695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EY643_RS06700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EY643_RS06705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EY643_RS06710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EY643_RS06715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EY643_RS06720	COG0072	phenylalanine-tRNA ligase activity
EY643_RS06725	COG0776	regulation of translation
EY643_RS06755	COG2070	2-Nitropropane dioxygenase
EY643_RS06765	COG1024	Enoyl-CoA hydratase
EY643_RS06775	COG1960	acyl-CoA dehydrogenase activity
EY643_RS06785	COG0183	Belongs to the thiolase family
EY643_RS06795	COG2031	fatty acid transporter
EY643_RS06805	COG1454	alcohol dehydrogenase
EY643_RS06810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EY643_RS06815	COG1902	pentaerythritol trinitrate reductase activity
EY643_RS06815	COG0446	pyridine nucleotide-disulphide oxidoreductase
EY643_RS06820	COG1252	NADH dehydrogenase
EY643_RS06840	COG1902	pentaerythritol trinitrate reductase activity
EY643_RS06900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EY643_RS06920	COG0625	glutathione transferase activity
EY643_RS06940	COG1024	Enoyl-CoA hydratase
EY643_RS06965	COG1024	Enoyl-CoA hydratase
EY643_RS06965	COG1250	3-hydroxyacyl-CoA dehydrogenase
EY643_RS06970	COG1309	transcriptional regulator
EY643_RS06975	COG0346	lactoylglutathione lyase activity
EY643_RS06980	COG1024	Enoyl-CoA hydratase
EY643_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS06990	COG1960	acyl-CoA dehydrogenase activity
EY643_RS07055	COG3706	GGDEF domain
EY643_RS07055	COG4251	negative regulation of phosphorylation
EY643_RS07055	COG5001	Diguanylate cyclase
EY643_RS07055	COG2203	Gaf domain
EY643_RS07060	COG4771	TonB-dependent receptor
EY643_RS07070	COG3706	GGDEF domain
EY643_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS07090	COG1024	Enoyl-CoA hydratase
EY643_RS07095	COG0583	DNA-binding transcription factor activity
EY643_RS07100	COG0604	alcohol dehydrogenase
EY643_RS07100	COG3321	synthase
EY643_RS07105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EY643_RS07110	COG0300	oxidoreductase activity
EY643_RS07130	COG2211	Major facilitator Superfamily
EY643_RS07140	COG2723	6-phospho-beta-galactosidase activity
EY643_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS07170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EY643_RS07175	COG1085	galactose-1-phosphate uridylyltransferase
EY643_RS07185	COG0235	Class ii aldolase
EY643_RS07220	COG1595	DNA-templated transcription, initiation
EY643_RS07225	COG1404	Belongs to the peptidase S8 family
EY643_RS07245	COG0076	glutamate decarboxylase activity
EY643_RS07260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EY643_RS07270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EY643_RS07275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EY643_RS07305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EY643_RS07305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EY643_RS07320	COG1643	Atp-dependent helicase
EY643_RS07330	COG3220	belongs to the UPF0276 family
EY643_RS07340	COG2853	Lipoprotein
EY643_RS07355	COG4206	TonB-dependent receptor
EY643_RS07370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EY643_RS07380	COG1250	3-hydroxyacyl-CoA dehydrogenase
EY643_RS07380	COG1024	Enoyl-CoA hydratase
EY643_RS07415	COG3909	cytochrome
EY643_RS07425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EY643_RS07445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EY643_RS07450	COG0343	queuine tRNA-ribosyltransferase activity
EY643_RS07455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EY643_RS07455	COG3323	Protein of unknown function (DUF1653)
EY643_RS07460	COG0494	nUDIX hydrolase
EY643_RS07475	COG4536	flavin adenine dinucleotide binding
EY643_RS07480	COG4137	Cytochrome C assembly protein
EY643_RS07485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EY643_RS07490	COG0228	four-way junction DNA binding
EY643_RS07495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EY643_RS07500	COG0336	Belongs to the RNA methyltransferase TrmD family
EY643_RS07505	COG0335	large ribosomal subunit rRNA binding
EY643_RS07515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EY643_RS07520	COG0436	Aminotransferase
EY643_RS07535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EY643_RS07540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EY643_RS07545	COG0789	Transcriptional regulator
EY643_RS07555	COG0564	pseudouridine synthase activity
EY643_RS07560	COG2264	protein methyltransferase activity
EY643_RS07565	COG0825	malonyl-CoA metabolic process
EY643_RS07570	COG0037	tRNA processing
EY643_RS07575	COG0504	CTP synthase activity
EY643_RS07580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EY643_RS07585	COG0148	phosphopyruvate hydratase activity
EY643_RS07600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EY643_RS07605	COG0585	pseudouridine synthase activity
EY643_RS07610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EY643_RS07640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EY643_RS07660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EY643_RS07680	COG2130	NADP-dependent
EY643_RS07690	COG2814	Major facilitator Superfamily
EY643_RS07700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EY643_RS07725	COG3246	L-lysine catabolic process to acetate
EY643_RS07760	COG2095	MarC family integral membrane protein
EY643_RS07765	COG1012	belongs to the aldehyde dehydrogenase family
EY643_RS07775	COG0277	FAD linked oxidase domain protein
EY643_RS07785	COG2130	NADP-dependent
EY643_RS07790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EY643_RS07800	COG4946	Tricorn protease homolog
EY643_RS07800	COG1506	peptidase
EY643_RS07800	COG0823	Involved in the tonB-independent uptake of proteins
EY643_RS07825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EY643_RS07835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EY643_RS07840	COG1960	acyl-CoA dehydrogenase activity
EY643_RS07870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EY643_RS07880	COG3186	Phenylalanine-4-hydroxylase
EY643_RS07895	COG0346	lactoylglutathione lyase activity
EY643_RS07905	COG1522	sequence-specific DNA binding
EY643_RS07935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EY643_RS07955	COG0596	Alpha beta hydrolase
EY643_RS07960	COG1024	Enoyl-CoA hydratase
EY643_RS07975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EY643_RS07980	COG1960	acyl-CoA dehydrogenase activity
EY643_RS07990	COG1960	acyl-CoA dehydrogenase activity
EY643_RS08030	COG2814	Major facilitator Superfamily
EY643_RS08040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EY643_RS08045	COG0174	glutamine synthetase
EY643_RS08050	COG1454	alcohol dehydrogenase
EY643_RS08055	COG0385	Bile acid
EY643_RS08075	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EY643_RS08095	COG1024	Enoyl-CoA hydratase
EY643_RS08105	COG4221	oxidoreductase activity
EY643_RS08120	COG0583	DNA-binding transcription factor activity
EY643_RS08125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EY643_RS08145	COG3383	formate dehydrogenase (NAD+) activity
EY643_RS08150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EY643_RS08160	COG2968	Membrane
EY643_RS08200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EY643_RS08210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EY643_RS08220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EY643_RS08225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EY643_RS08230	COG1492	cobalamin metabolic process
EY643_RS08235	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EY643_RS08240	COG4206	TonB-dependent receptor
EY643_RS08245	COG0406	alpha-ribazole phosphatase activity
EY643_RS08255	COG0778	Nitroreductase
EY643_RS08280	COG1739	Uncharacterized protein family UPF0029
EY643_RS08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EY643_RS08300	COG0668	transmembrane transport
EY643_RS08310	COG5002	protein histidine kinase activity
EY643_RS08315	COG2165	general secretion pathway protein
EY643_RS08335	COG0019	diaminopimelate decarboxylase activity
EY643_RS08345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EY643_RS08360	COG0529	Catalyzes the synthesis of activated sulfate
EY643_RS08365	COG2046	Belongs to the sulfate adenylyltransferase family
EY643_RS08380	COG1902	pentaerythritol trinitrate reductase activity
EY643_RS08385	COG0471	metal ion transport
EY643_RS08385	COG3273	potassium ion transport
EY643_RS08400	COG1902	pentaerythritol trinitrate reductase activity
EY643_RS08430	COG1090	epimerase
EY643_RS08470	COG0811	peptide transport
EY643_RS08480	COG0848	biopolymer transport protein
EY643_RS08495	COG1228	amidohydrolase
EY643_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS08520	COG2030	dehydratase
EY643_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS08560	COG0183	Belongs to the thiolase family
EY643_RS08595	COG1960	acyl-CoA dehydrogenase activity
EY643_RS08600	COG1309	transcriptional regulator
EY643_RS08605	COG1960	acyl-CoA dehydrogenase activity
EY643_RS08630	COG1309	transcriptional regulator
EY643_RS08640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EY643_RS08650	COG2175	clavaminate synthase activity
EY643_RS08655	COG2205	protein histidine kinase activity
EY643_RS08660	COG0745	RESPONSE REGULATOR receiver
EY643_RS08675	COG4771	TonB-dependent receptor
EY643_RS08695	COG2188	Transcriptional regulator
EY643_RS08710	COG1335	isochorismatase
EY643_RS08715	COG3710	Transcriptional regulator
EY643_RS08725	COG0252	asparaginase activity
EY643_RS08735	COG1733	regulation of RNA biosynthetic process
EY643_RS08745	COG0625	glutathione transferase activity
EY643_RS08750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EY643_RS08760	COG1760	l-serine dehydratase
EY643_RS08770	COG3012	SEC-C Motif Domain Protein
EY643_RS08775	COG0488	(ABC) transporter
EY643_RS08785	COG0513	Belongs to the DEAD box helicase family
EY643_RS08790	COG1047	Peptidyl-prolyl cis-trans
EY643_RS08820	COG1473	amidohydrolase
EY643_RS08840	COG4771	TonB-dependent receptor
EY643_RS08845	COG1472	Belongs to the glycosyl hydrolase 3 family
EY643_RS08855	COG1024	Enoyl-CoA hydratase
EY643_RS08860	COG1960	acyl-CoA dehydrogenase activity
EY643_RS08870	COG3038	cytochrome b561
EY643_RS08875	COG2814	Major facilitator Superfamily
EY643_RS08930	COG2211	Major facilitator Superfamily
EY643_RS08935	COG1024	Enoyl-CoA hydratase
EY643_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS08950	COG1024	Enoyl-CoA hydratase
EY643_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS08960	COG1063	alcohol dehydrogenase
EY643_RS08975	COG2186	Transcriptional regulator
EY643_RS08980	COG2072	flavoprotein involved in K transport
EY643_RS08995	COG1022	Amp-dependent synthetase and ligase
EY643_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS09040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EY643_RS09070	COG2070	2-Nitropropane dioxygenase
EY643_RS09075	COG4654	Cytochrome c, class I
EY643_RS09090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EY643_RS09105	COG0577	efflux transmembrane transporter activity
EY643_RS09105	COG1136	(ABC) transporter
EY643_RS09150	COG0346	lactoylglutathione lyase activity
EY643_RS09180	COG1024	Enoyl-CoA hydratase
EY643_RS09185	COG0778	Nitroreductase
EY643_RS09190	COG1024	Enoyl-CoA hydratase
EY643_RS09215	COG0183	Belongs to the thiolase family
EY643_RS09245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EY643_RS09255	COG1842	Phage shock protein A
EY643_RS09265	COG1983	PspC domain protein
EY643_RS09280	COG0589	response to stress
EY643_RS09290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EY643_RS09300	COG2354	Protein conserved in bacteria
EY643_RS09315	COG0433	COG0433 Predicted ATPase
EY643_RS09320	COG2321	neutral zinc metallopeptidase
EY643_RS09335	COG0390	transport system, permease component
EY643_RS09365	COG0534	Mate efflux family protein
EY643_RS09385	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EY643_RS09385	COG0674	pyruvate-flavodoxin oxidoreductase activity
EY643_RS09385	COG1013	pyruvate-flavodoxin oxidoreductase activity
EY643_RS09385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EY643_RS09400	COG1643	Atp-dependent helicase
EY643_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS09420	COG4771	TonB-dependent receptor
EY643_RS09425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EY643_RS09445	COG4181	ATPase activity
EY643_RS09450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EY643_RS09460	COG0039	L-malate dehydrogenase activity
EY643_RS09475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EY643_RS09490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EY643_RS09495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EY643_RS09505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EY643_RS09510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EY643_RS09535	COG0544	peptidyl-prolyl cis-trans isomerase activity
EY643_RS09540	COG0740	serine-type endopeptidase activity
EY643_RS09545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EY643_RS09550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EY643_RS09560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EY643_RS09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EY643_RS09600	COG0405	Gamma-glutamyltransferase
EY643_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS09650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EY643_RS09665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EY643_RS09670	COG1132	(ABC) transporter
EY643_RS09675	COG1132	(ABC) transporter
EY643_RS09680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EY643_RS09680	COG2111	Na H antiporter
EY643_RS09690	COG0651	ATP synthesis coupled electron transport
EY643_RS09695	COG0651	ATP synthesis coupled electron transport
EY643_RS09700	COG1006	Multisubunit Na H antiporter MnhC subunit
EY643_RS09710	COG1320	monovalent cation:proton antiporter activity
EY643_RS09715	COG2212	antiporter activity
EY643_RS09720	COG1863	multisubunit Na H antiporter MnhE subunit
EY643_RS09805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EY643_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
EY643_RS09870	COG0673	inositol 2-dehydrogenase activity
EY643_RS09885	COG4206	TonB-dependent receptor
EY643_RS09895	COG0246	Mannitol dehydrogenase
EY643_RS09900	COG1904	glucuronate isomerase
EY643_RS09905	COG2186	Transcriptional regulator
EY643_RS09920	COG0673	inositol 2-dehydrogenase activity
EY643_RS09925	COG1312	Catalyzes the dehydration of D-mannonate
EY643_RS09930	COG0500	methyltransferase
EY643_RS09940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EY643_RS09950	COG0515	serine threonine protein kinase
EY643_RS09950	COG2815	serine threonine protein kinase
EY643_RS09955	COG1024	Enoyl-CoA hydratase
EY643_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS09980	COG0515	serine threonine protein kinase
EY643_RS09980	COG2815	serine threonine protein kinase
EY643_RS09995	COG0616	signal peptide processing
EY643_RS10005	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EY643_RS10010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EY643_RS10015	COG0328	RNA-DNA hybrid ribonuclease activity
EY643_RS10020	COG2226	methyltransferase
EY643_RS10025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EY643_RS10030	COG1388	LysM domain
EY643_RS10030	COG0741	lytic transglycosylase activity
EY643_RS10035	COG2813	Specifically methylates the guanine in position
EY643_RS10050	COG1074	ATP-dependent DNA helicase activity
EY643_RS10060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EY643_RS10065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EY643_RS10065	COG0316	Belongs to the HesB IscA family
EY643_RS10080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EY643_RS10090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EY643_RS10090	COG0475	glutathione-regulated potassium exporter activity
EY643_RS10110	COG1648	precorrin-2 dehydrogenase activity
EY643_RS10110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EY643_RS10115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EY643_RS10120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EY643_RS10125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EY643_RS10130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EY643_RS10135	COG1674	ftsk spoiiie
EY643_RS10140	COG0492	ferredoxin-NADP+ reductase activity
EY643_RS10145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EY643_RS10150	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EY643_RS10155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EY643_RS10160	COG0542	response to heat
EY643_RS10165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EY643_RS10180	COG0482	sulfurtransferase activity
EY643_RS10185	COG2915	High frequency lysogenization protein hflD homolog
EY643_RS10195	COG2850	peptidyl-arginine hydroxylation
EY643_RS10225	COG1703	isobutyryl-CoA mutase activity
EY643_RS10230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EY643_RS10230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EY643_RS10240	COG0439	Biotin carboxylase
EY643_RS10245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EY643_RS10255	COG0560	Phosphoserine phosphatase
EY643_RS10270	COG0427	acetyl-CoA hydrolase
EY643_RS10275	COG1115	amino acid carrier protein
EY643_RS10280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EY643_RS10285	COG1862	Preprotein translocase
EY643_RS10290	COG0708	Exodeoxyribonuclease III
EY643_RS10305	COG0537	adenosine 5'-monophosphoramidase activity
EY643_RS10310	COG2124	cytochrome p450
EY643_RS10320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EY643_RS10330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EY643_RS10335	COG0314	molybdopterin synthase activity
EY643_RS10340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EY643_RS10345	COG0315	cyclic pyranopterin monophosphate synthase activity
EY643_RS10350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EY643_RS10365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EY643_RS10365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EY643_RS10370	COG0842	Transport permease protein
EY643_RS10375	COG1131	(ABC) transporter
EY643_RS10405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EY643_RS10415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EY643_RS10425	COG3101	peptidyl-lysine hydroxylation
EY643_RS10450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EY643_RS10460	COG0302	gtp cyclohydrolase
EY643_RS10470	COG0596	Alpha beta hydrolase
EY643_RS10480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EY643_RS10485	COG0326	Molecular chaperone. Has ATPase activity
EY643_RS10495	COG0045	succinate-CoA ligase (ADP-forming) activity
EY643_RS10500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EY643_RS10520	COG1053	succinate dehydrogenase
EY643_RS10545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EY643_RS10560	COG0704	Plays a role in the regulation of phosphate uptake
EY643_RS10565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EY643_RS10575	COG0573	inorganic phosphate transmembrane transporter activity
EY643_RS10610	COG0674	pyruvate-flavodoxin oxidoreductase activity
EY643_RS10610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EY643_RS10615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EY643_RS10615	COG0493	'glutamate synthase
EY643_RS10625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EY643_RS10630	COG3115	cell septum assembly
EY643_RS10635	COG1196	nuclear chromosome segregation
EY643_RS10640	COG4235	cytochrome complex assembly
EY643_RS10655	COG1138	Cytochrome C-type biogenesis protein
EY643_RS10660	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EY643_RS10680	COG4133	protoheme IX ABC transporter activity
EY643_RS10685	COG0037	tRNA processing
EY643_RS10695	COG3119	arylsulfatase activity
EY643_RS10705	COG3848	Pyruvate phosphate dikinase
EY643_RS10705	COG0574	Belongs to the PEP-utilizing enzyme family
EY643_RS10725	COG0546	phosphoglycolate phosphatase activity
EY643_RS10730	COG0564	pseudouridine synthase activity
EY643_RS10735	COG1530	ribonuclease E activity
EY643_RS10745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EY643_RS10760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EY643_RS10770	COG0670	Belongs to the BI1 family
EY643_RS10775	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EY643_RS10795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EY643_RS10825	COG0733	neurotransmitter:sodium symporter activity
EY643_RS10840	COG0789	Transcriptional regulator
EY643_RS10855	COG1090	epimerase
EY643_RS10860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EY643_RS10895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EY643_RS10900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EY643_RS10905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EY643_RS10915	COG1132	(ABC) transporter
EY643_RS10920	COG0848	biopolymer transport protein
EY643_RS10925	COG0811	peptide transport
EY643_RS10940	COG4591	ABC-type transport system involved in lipoprotein release permease component
EY643_RS10945	COG1136	(ABC) transporter
EY643_RS10960	COG1477	protein flavinylation
EY643_RS10965	COG2871	sodium ion transport
EY643_RS10970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EY643_RS10985	COG1805	sodium ion transport
EY643_RS10990	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EY643_RS11000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EY643_RS11015	COG0668	transmembrane transport
EY643_RS11025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EY643_RS11050	COG0589	response to stress
EY643_RS11065	COG2207	Transcriptional regulator
EY643_RS11080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EY643_RS11090	COG2983	Belongs to the UPF0260 family
EY643_RS11095	COG3100	YcgL domain-containing protein
EY643_RS11105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EY643_RS11110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EY643_RS11130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EY643_RS11140	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EY643_RS11160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EY643_RS11165	COG0215	cysteine-tRNA ligase activity
EY643_RS11170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EY643_RS11180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EY643_RS11195	COG1049	propionate catabolic process, 2-methylcitrate cycle
EY643_RS11200	COG0243	molybdopterin cofactor binding
EY643_RS11215	COG3268	Saccharopine dehydrogenase
EY643_RS11240	COG0714	Associated with various cellular activities
EY643_RS11255	COG1286	toxin biosynthetic process
EY643_RS11265	COG0285	dihydrofolate synthase activity
EY643_RS11270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EY643_RS11275	COG0159	tryptophan synthase activity
EY643_RS11285	COG0135	phosphoribosylanthranilate isomerase activity
EY643_RS11300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EY643_RS11305	COG0473	3-isopropylmalate dehydrogenase activity
EY643_RS11310	COG0066	3-isopropylmalate dehydratase activity
EY643_RS11315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EY643_RS11335	COG2130	NADP-dependent
EY643_RS11340	COG0116	Belongs to the methyltransferase superfamily
EY643_RS11340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EY643_RS11370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EY643_RS11370	COG0574	Belongs to the PEP-utilizing enzyme family
EY643_RS11390	COG2885	chlorophyll binding
EY643_RS11400	COG0729	surface antigen
EY643_RS11405	COG2226	methyltransferase
EY643_RS11440	COG0596	Alpha beta hydrolase
EY643_RS11450	COG1960	acyl-CoA dehydrogenase activity
EY643_RS11455	COG1960	acyl-CoA dehydrogenase activity
EY643_RS11460	COG2900	Belongs to the SlyX family
EY643_RS11465	COG0023	Translation Initiation Factor
EY643_RS11490	COG0741	lytic transglycosylase activity
EY643_RS11495	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EY643_RS11500	COG4638	Rieske (2fe-2S)
EY643_RS11600	COG1278	Cold shock
EY643_RS11615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EY643_RS11625	COG0402	S-adenosylhomocysteine deaminase activity
EY643_RS11635	COG2205	protein histidine kinase activity
EY643_RS11705	COG0385	Bile acid
EY643_RS11730	COG3842	ATPase activity
EY643_RS11735	COG1178	ABC-type Fe3 transport system permease component
EY643_RS11740	COG1840	ABC-type Fe3 transport system, periplasmic component
EY643_RS11805	COG1741	Belongs to the pirin family
EY643_RS11810	COG0435	Glutathione S-transferase
EY643_RS11815	COG0583	DNA-binding transcription factor activity
EY643_RS11825	COG0633	Ferredoxin
EY643_RS11825	COG0543	2 iron, 2 sulfur cluster binding
EY643_RS11860	COG1309	transcriptional regulator
EY643_RS11895	COG5001	Diguanylate cyclase
EY643_RS11895	COG3300	MHYT domain
EY643_RS11905	COG0625	glutathione transferase activity
EY643_RS11910	COG2062	phosphohistidine phosphatase, SixA
EY643_RS11915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EY643_RS11920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EY643_RS11945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS11965	COG1597	lipid kinase activity
EY643_RS11970	COG4948	Mandelate Racemase Muconate Lactonizing
EY643_RS11990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EY643_RS12040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EY643_RS12045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EY643_RS12055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EY643_RS12075	COG1278	Cold shock
EY643_RS12085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS12120	COG0415	Belongs to the DNA photolyase family
EY643_RS12135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EY643_RS12150	COG1595	DNA-templated transcription, initiation
EY643_RS12160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EY643_RS12165	COG0714	Associated with various cellular activities
EY643_RS12170	COG0302	gtp cyclohydrolase
EY643_RS12185	COG1671	Belongs to the UPF0178 family
EY643_RS12195	COG0432	Pfam Uncharacterised protein family UPF0047
EY643_RS12230	COG0789	Transcriptional regulator
EY643_RS12240	COG4106	trans-aconitate 2-methyltransferase activity
EY643_RS12285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS12335	COG2199	diguanylate cyclase activity
EY643_RS12335	COG2200	EAL domain
EY643_RS12335	COG3287	FIST C domain
EY643_RS12340	COG0277	FAD linked oxidase domain protein
EY643_RS12345	COG0277	FAD linked oxidase domain protein
EY643_RS12350	COG0247	lactate metabolic process
EY643_RS12355	COG1022	Amp-dependent synthetase and ligase
EY643_RS12375	COG3130	regulation of translation
EY643_RS12385	COG0714	Associated with various cellular activities
EY643_RS12405	COG2304	oxidoreductase activity
EY643_RS12415	COG0308	aminopeptidase N
EY643_RS12425	COG3139	Protein of unknown function (DUF1315)
EY643_RS12435	COG0705	Rhomboid family
EY643_RS12440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EY643_RS12460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EY643_RS12470	COG1053	succinate dehydrogenase
EY643_RS12475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EY643_RS12480	COG5265	(ABC) transporter
EY643_RS12485	COG3275	phosphorelay sensor kinase activity
EY643_RS12490	COG3279	Response regulator of the LytR AlgR family
EY643_RS12500	COG2815	serine threonine protein kinase
EY643_RS12500	COG0515	serine threonine protein kinase
EY643_RS12530	COG0720	synthase
EY643_RS12535	COG1309	transcriptional regulator
EY643_RS12545	COG1012	belongs to the aldehyde dehydrogenase family
EY643_RS12565	COG0596	Alpha beta hydrolase
EY643_RS12585	COG0778	Nitroreductase
EY643_RS12600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EY643_RS12610	COG1960	acyl-CoA dehydrogenase activity
EY643_RS12640	COG0625	glutathione transferase activity
EY643_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS12670	COG2211	Major facilitator Superfamily
EY643_RS12680	COG1250	3-hydroxyacyl-CoA dehydrogenase
EY643_RS12695	COG0678	peroxiredoxin activity
EY643_RS12705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EY643_RS12710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EY643_RS12725	COG0633	Ferredoxin
EY643_RS12735	COG0401	homolog of Blt101
EY643_RS12760	COG0583	DNA-binding transcription factor activity
EY643_RS12770	COG3813	Protein conserved in bacteria
EY643_RS12790	COG1012	belongs to the aldehyde dehydrogenase family
EY643_RS12850	COG3153	acetyltransferase
EY643_RS12850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EY643_RS12860	COG4221	oxidoreductase activity
EY643_RS12900	COG1335	isochorismatase
EY643_RS12910	COG1012	belongs to the aldehyde dehydrogenase family
EY643_RS12915	COG1960	acyl-CoA dehydrogenase activity
EY643_RS12940	COG3347	Dehydrogenase
EY643_RS12940	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS12965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EY643_RS12980	COG0596	Alpha beta hydrolase
EY643_RS13005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EY643_RS13010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EY643_RS13025	COG1362	aminopeptidase activity
EY643_RS13030	COG2084	Dehydrogenase
EY643_RS13035	COG1968	undecaprenyl-diphosphatase activity
EY643_RS13045	COG0746	molybdenum cofactor guanylyltransferase activity
EY643_RS13055	COG0563	adenylate kinase activity
EY643_RS13060	COG3956	TIGRFAM MazG family protein
EY643_RS13065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EY643_RS13075	COG1381	Involved in DNA repair and RecF pathway recombination
EY643_RS13080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EY643_RS13085	COG0571	ribonuclease III activity
EY643_RS13100	COG0481	GTPase activity
EY643_RS13105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EY643_RS13115	COG3026	antisigma factor binding
EY643_RS13140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EY643_RS13165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EY643_RS13175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EY643_RS13180	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EY643_RS13180	COG0778	Nitroreductase
EY643_RS13190	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS13200	COG5001	Diguanylate cyclase
EY643_RS13200	COG5002	protein histidine kinase activity
EY643_RS13215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EY643_RS13225	COG3278	Belongs to the heme-copper respiratory oxidase family
EY643_RS13240	COG2010	Cytochrome c
EY643_RS13275	COG3047	cAMP biosynthetic process
EY643_RS13285	COG2962	Rard protein
EY643_RS13320	COG1960	acyl-CoA dehydrogenase activity
EY643_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS13340	COG0271	Belongs to the BolA IbaG family
EY643_RS13345	COG2207	Transcriptional regulator
EY643_RS13345	COG4753	response regulator
EY643_RS13355	COG2205	protein histidine kinase activity
EY643_RS13360	COG0745	RESPONSE REGULATOR receiver
EY643_RS13370	COG0795	lipopolysaccharide-transporting ATPase activity
EY643_RS13375	COG0795	lipopolysaccharide-transporting ATPase activity
EY643_RS13380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EY643_RS13390	COG0525	valine-tRNA ligase activity
EY643_RS13450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EY643_RS13460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EY643_RS13470	COG1737	Transcriptional regulator
EY643_RS13480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EY643_RS13485	COG3568	Endonuclease Exonuclease Phosphatase
EY643_RS13490	COG0318	PFAM AMP-dependent synthetase and ligase
EY643_RS13495	COG0513	Belongs to the DEAD box helicase family
EY643_RS13515	COG2226	methyltransferase
EY643_RS13520	COG1024	Enoyl-CoA hydratase
EY643_RS13535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS13540	COG1757	Na H antiporter
EY643_RS13545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EY643_RS13555	COG3713	MltA-interacting MipA family protein
EY643_RS13575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EY643_RS13595	COG0427	acetyl-CoA hydrolase
EY643_RS13640	COG1063	alcohol dehydrogenase
EY643_RS13645	COG0156	8-amino-7-oxononanoate synthase activity
EY643_RS13655	COG1160	GTP binding
EY643_RS13675	COG0217	transcriptional regulatory protein
EY643_RS13710	COG3264	Mechanosensitive ion channel
EY643_RS13710	COG1511	domain protein
EY643_RS13720	COG4753	response regulator
EY643_RS13720	COG2207	Transcriptional regulator
EY643_RS13730	COG0183	Belongs to the thiolase family
EY643_RS13780	COG1960	acyl-CoA dehydrogenase activity
EY643_RS13785	COG0596	Alpha beta hydrolase
EY643_RS13820	COG3119	arylsulfatase activity
EY643_RS13870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EY643_RS13870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EY643_RS13890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EY643_RS13895	COG0527	aspartate kinase activity
EY643_RS13900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EY643_RS13905	COG0537	adenosine 5'-monophosphoramidase activity
EY643_RS13910	COG2835	tetraacyldisaccharide 4'-kinase activity
EY643_RS13940	COG1573	uracil-dna glycosylase
EY643_RS13945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EY643_RS13945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EY643_RS13990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS14000	COG3119	arylsulfatase activity
EY643_RS14020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EY643_RS14030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EY643_RS14035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EY643_RS14040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EY643_RS14050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EY643_RS14060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EY643_RS14075	COG0233	cytoplasmic translational termination
EY643_RS14080	COG0528	UMP kinase activity
EY643_RS14100	COG0459	protein refolding
EY643_RS14105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EY643_RS14120	COG3695	enzyme binding
EY643_RS14130	COG2814	Major facilitator Superfamily
EY643_RS14140	COG1215	transferase activity, transferring glycosyl groups
EY643_RS14150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EY643_RS14165	COG1450	Type ii and iii secretion system protein
EY643_RS14195	COG2165	general secretion pathway protein
EY643_RS14200	COG4969	Belongs to the N-Me-Phe pilin family
EY643_RS14205	COG2165	general secretion pathway protein
EY643_RS14210	COG1459	type II secretion system
EY643_RS14215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EY643_RS14220	COG0183	Belongs to the thiolase family
EY643_RS14230	COG1960	acyl-CoA dehydrogenase activity
EY643_RS14240	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS14245	COG0183	Belongs to the thiolase family
EY643_RS14250	COG1960	acyl-CoA dehydrogenase activity
EY643_RS14255	COG1960	acyl-CoA dehydrogenase activity
EY643_RS14260	COG1024	Enoyl-CoA hydratase
EY643_RS14310	COG1215	transferase activity, transferring glycosyl groups
EY643_RS14315	COG3769	mannosylglycerate metabolic process
EY643_RS14325	COG0508	dehydrogenase complex catalyzes the overall conversion of
EY643_RS14345	COG0425	Belongs to the sulfur carrier protein TusA family
EY643_RS14355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EY643_RS14370	COG1024	Enoyl-CoA hydratase
EY643_RS14390	COG1404	Belongs to the peptidase S8 family
EY643_RS14405	COG2205	protein histidine kinase activity
EY643_RS14405	COG0745	RESPONSE REGULATOR receiver
EY643_RS14405	COG0745	RESPONSE REGULATOR receiver
EY643_RS14405	COG2205	protein histidine kinase activity
EY643_RS14405	COG3292	Two component regulator propeller
EY643_RS14405	COG3292	Two component regulator propeller
EY643_RS14415	COG1024	Enoyl-CoA hydratase
EY643_RS14420	COG0519	Catalyzes the synthesis of GMP from XMP
EY643_RS14425	COG0534	Mate efflux family protein
EY643_RS14440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EY643_RS14445	COG1960	acyl-CoA dehydrogenase activity
EY643_RS14450	COG1960	acyl-CoA dehydrogenase activity
EY643_RS14455	COG3118	belongs to the thioredoxin family
EY643_RS14460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EY643_RS14465	COG0484	heat shock protein binding
EY643_RS14470	COG0443	Heat shock 70 kDa protein
EY643_RS14475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EY643_RS14480	COG1420	regulation of RNA biosynthetic process
EY643_RS14485	COG0497	DNA recombination
EY643_RS14490	COG0735	belongs to the Fur family
EY643_RS14500	COG2914	Belongs to the UPF0125 (RnfH) family
EY643_RS14510	COG0733	neurotransmitter:sodium symporter activity
EY643_RS14515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EY643_RS14520	COG0730	response to heat
EY643_RS14575	COG3046	protein related to deoxyribodipyrimidine photolyase
EY643_RS14580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EY643_RS14610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EY643_RS14615	COG1879	ABC-type sugar transport system periplasmic component
EY643_RS14620	COG1129	ABC transporter
EY643_RS14625	COG1172	Belongs to the binding-protein-dependent transport system permease family
EY643_RS14630	COG0604	alcohol dehydrogenase
EY643_RS14635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EY643_RS14640	COG0583	DNA-binding transcription factor activity
EY643_RS14650	COG1505	serine-type exopeptidase activity
EY643_RS14670	COG1505	serine-type exopeptidase activity
EY643_RS14675	COG0584	glycerophosphoryl diester phosphodiesterase
EY643_RS14705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EY643_RS14720	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EY643_RS14735	COG1609	Transcriptional regulator
EY643_RS14740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EY643_RS14745	COG0363	glucosamine-6-phosphate deaminase activity
EY643_RS14750	COG2971	BadF BadG BcrA BcrD
EY643_RS14760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EY643_RS14775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EY643_RS14785	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EY643_RS14820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EY643_RS14870	COG3226	Transcriptional regulator
EY643_RS14880	COG2211	Major facilitator Superfamily
EY643_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS14935	COG2030	dehydratase
EY643_RS14950	COG0179	Fumarylacetoacetate (FAA) hydrolase
EY643_RS14990	COG1053	succinate dehydrogenase
EY643_RS14995	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS15010	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS15030	COG3655	Transcriptional regulator
EY643_RS15080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS15095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EY643_RS15095	COG0515	serine threonine protein kinase
EY643_RS15100	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EY643_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS15155	COG1595	DNA-templated transcription, initiation
EY643_RS15180	COG2252	PERMEase
EY643_RS15205	COG2832	Protein of unknown function (DUF454)
EY643_RS15210	COG0045	succinate-CoA ligase (ADP-forming) activity
EY643_RS15210	COG1042	CoA-binding domain protein
EY643_RS15210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EY643_RS15215	COG0123	including yeast histone deacetylase and acetoin utilization protein
EY643_RS15220	COG0475	glutathione-regulated potassium exporter activity
EY643_RS15225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EY643_RS15225	COG2124	cytochrome p450
EY643_RS15260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EY643_RS15280	COG5001	Diguanylate cyclase
EY643_RS15280	COG3300	MHYT domain
EY643_RS15295	COG2197	response regulator
EY643_RS15300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS15315	COG1612	heme a metabolic process
EY643_RS15325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EY643_RS15330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EY643_RS15335	COG0183	Belongs to the thiolase family
EY643_RS15350	COG1448	Aminotransferase
EY643_RS15355	COG2195	Cleaves the N-terminal amino acid of tripeptides
EY643_RS15370	COG4106	trans-aconitate 2-methyltransferase activity
EY643_RS15375	COG0500	methyltransferase
EY643_RS15380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EY643_RS15395	COG2249	NAD(P)H dehydrogenase (quinone) activity
EY643_RS15405	COG4191	Histidine kinase
EY643_RS15410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EY643_RS15415	COG0321	lipoyl(octanoyl) transferase activity
EY643_RS15420	COG2921	Belongs to the UPF0250 family
EY643_RS15425	COG1686	Belongs to the peptidase S11 family
EY643_RS15435	COG2951	lytic endotransglycosylase activity
EY643_RS15440	COG0772	Belongs to the SEDS family
EY643_RS15445	COG0768	penicillin binding
EY643_RS15450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EY643_RS15460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EY643_RS15465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EY643_RS15470	COG0450	alkyl hydroperoxide reductase
EY643_RS15480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EY643_RS15485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EY643_RS15490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EY643_RS15495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EY643_RS15495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EY643_RS15500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EY643_RS15530	COG0183	Belongs to the thiolase family
EY643_RS15545	COG2258	MOSC domain
EY643_RS15550	COG1199	ATP-dependent helicase activity
EY643_RS15570	COG2365	Tyrosine phosphatase family
EY643_RS15575	COG1309	transcriptional regulator
EY643_RS15580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EY643_RS15585	COG0268	Binds directly to 16S ribosomal RNA
EY643_RS15620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EY643_RS15625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EY643_RS15650	COG0678	peroxiredoxin activity
EY643_RS15670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EY643_RS15705	COG2918	glutathione biosynthetic process
EY643_RS15730	COG1846	Transcriptional regulator
EY643_RS15735	COG0488	(ABC) transporter
EY643_RS15740	COG1162	GTPase activity
EY643_RS15760	COG2326	polyphosphate kinase activity
EY643_RS15770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EY643_RS15775	COG0303	'Molybdopterin
EY643_RS15780	COG0521	Mo-molybdopterin cofactor biosynthetic process
EY643_RS15790	COG3119	arylsulfatase activity
EY643_RS15800	COG2814	Major facilitator Superfamily
EY643_RS15820	COG0745	RESPONSE REGULATOR receiver
EY643_RS15820	COG2972	Histidine kinase
EY643_RS15850	COG4968	Prepilin-type N-terminal cleavage methylation domain
EY643_RS15860	COG0203	ribosomal protein L17
EY643_RS15865	COG0202	RNA polymerase activity
EY643_RS15870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EY643_RS15875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EY643_RS15880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EY643_RS15895	COG0200	Binds to the 23S rRNA
EY643_RS15900	COG1841	ribosomal large subunit assembly
EY643_RS15905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EY643_RS15910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EY643_RS15915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EY643_RS15920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EY643_RS15925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EY643_RS15930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EY643_RS15935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EY643_RS15940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EY643_RS15945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EY643_RS15950	COG0255	Belongs to the universal ribosomal protein uL29 family
EY643_RS15955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EY643_RS15960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EY643_RS15965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EY643_RS15970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EY643_RS15975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EY643_RS15985	COG0088	Forms part of the polypeptide exit tunnel
EY643_RS15990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EY643_RS15995	COG0051	transcription antitermination factor activity, RNA binding
EY643_RS16000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EY643_RS16015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EY643_RS16020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EY643_RS16030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EY643_RS16035	COG1702	phosphate starvation-inducible protein PhoH
EY643_RS16040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EY643_RS16055	COG0495	leucyl-tRNA aminoacylation
EY643_RS16065	COG1466	dna polymerase III delta subunit
EY643_RS16090	COG0589	response to stress
EY643_RS16095	COG2824	Alkylphosphonate utilization operon protein PhnA
EY643_RS16100	COG0456	acetyltransferase
EY643_RS16155	COG4771	TonB-dependent receptor
EY643_RS16185	COG3040	lipid binding
EY643_RS16245	COG4974	Belongs to the 'phage' integrase family
EY643_RS16250	COG0587	DNA-directed DNA polymerase activity
EY643_RS16255	COG0346	lactoylglutathione lyase activity
EY643_RS16270	COG0137	argininosuccinate synthase activity
EY643_RS16275	COG0418	dihydroorotase activity
EY643_RS16305	COG0643	Histidine kinase
EY643_RS16305	COG0784	Response regulator, receiver
EY643_RS16305	COG2198	Histidine kinase
EY643_RS16335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EY643_RS16340	COG0205	6-phosphofructokinase activity
EY643_RS16345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EY643_RS16350	COG1876	peptidase activity
EY643_RS16355	COG1489	DNA binding
EY643_RS16360	COG0436	Aminotransferase
EY643_RS16370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EY643_RS16400	COG1428	Deoxynucleoside kinase
EY643_RS16405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EY643_RS16410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EY643_RS16415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EY643_RS16420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EY643_RS16430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EY643_RS16435	COG0142	geranyltranstransferase activity
EY643_RS16440	COG0166	Belongs to the GPI family
EY643_RS16460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EY643_RS16475	COG2959	enzyme of heme biosynthesis
EY643_RS16490	COG0165	Argininosuccinate lyase
EY643_RS16500	COG1965	Belongs to the frataxin family
EY643_RS16515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EY643_RS16525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EY643_RS16530	COG1011	Hydrolase
EY643_RS16545	COG0004	ammonium transporteR
EY643_RS16570	COG2124	cytochrome p450
EY643_RS16580	COG1024	Enoyl-CoA hydratase
EY643_RS16580	COG1250	3-hydroxyacyl-CoA dehydrogenase
EY643_RS16585	COG0183	Belongs to the thiolase family
EY643_RS16615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EY643_RS16625	COG0625	glutathione transferase activity
EY643_RS16635	COG1136	(ABC) transporter
EY643_RS16635	COG0577	efflux transmembrane transporter activity
EY643_RS16670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EY643_RS16685	COG1672	PFAM Archaeal ATPase
EY643_RS16685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EY643_RS16725	COG2204	response regulator
EY643_RS16775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EY643_RS16815	COG1309	transcriptional regulator
EY643_RS16830	COG4771	TonB-dependent receptor
EY643_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS16880	COG1960	acyl-CoA dehydrogenase activity
EY643_RS16930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EY643_RS16950	COG0508	dehydrogenase complex catalyzes the overall conversion of
EY643_RS16975	COG0583	DNA-binding transcription factor activity
EY643_RS17055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EY643_RS17070	COG1477	protein flavinylation
EY643_RS17075	COG4989	oxidoreductase activity
EY643_RS17080	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS17085	COG0596	Alpha beta hydrolase
EY643_RS17095	COG2066	Belongs to the glutaminase family
EY643_RS17105	COG0252	asparaginase activity
EY643_RS17115	COG3201	nicotinamide mononucleotide transporter
EY643_RS17125	COG1629	transport
EY643_RS17125	COG4774	siderophore transport
EY643_RS17130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS17140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EY643_RS17160	COG1757	Na H antiporter
EY643_RS17175	COG3977	Valine--pyruvate aminotransferase
EY643_RS17215	COG1013	pyruvate-flavodoxin oxidoreductase activity
EY643_RS17220	COG0674	pyruvate-flavodoxin oxidoreductase activity
EY643_RS17220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EY643_RS17230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EY643_RS17235	COG3422	double-strand break repair
EY643_RS17255	COG0167	dihydroorotate dehydrogenase activity
EY643_RS17265	COG2072	flavoprotein involved in K transport
EY643_RS17280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EY643_RS17300	COG1115	amino acid carrier protein
EY643_RS17315	COG0667	Aldo Keto reductase
EY643_RS17330	COG3119	arylsulfatase activity
EY643_RS17345	COG3001	Fructosamine kinase
EY643_RS17350	COG1960	acyl-CoA dehydrogenase activity
EY643_RS17365	COG0463	Glycosyl transferase, family 2
EY643_RS17375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EY643_RS17380	COG0859	PFAM glycosyl transferase family 9
EY643_RS17395	COG2937	Belongs to the GPAT DAPAT family
EY643_RS17400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EY643_RS17430	COG3119	arylsulfatase activity
EY643_RS17445	COG3119	arylsulfatase activity
EY643_RS17455	COG1566	PFAM secretion protein HlyD family protein
EY643_RS17505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EY643_RS17560	COG0183	Belongs to the thiolase family
EY643_RS17570	COG1021	2,3-dihydroxybenzoate-AMP ligase
EY643_RS17580	COG0686	Belongs to the AlaDH PNT family
EY643_RS17595	COG0583	DNA-binding transcription factor activity
EY643_RS17600	COG2197	response regulator
EY643_RS17605	COG0457	Tetratricopeptide repeat
EY643_RS17615	COG0174	glutamine synthetase
EY643_RS17625	COG0531	amino acid
EY643_RS17630	COG4124	Belongs to the glycosyl hydrolase 26 family
EY643_RS17635	COG2942	2-epimerase
EY643_RS17640	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EY643_RS17660	COG1609	Transcriptional regulator
EY643_RS17685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EY643_RS17690	COG3459	Glycosyltransferase 36 associated
EY643_RS17700	COG2211	Major facilitator Superfamily
EY643_RS17705	COG3459	Glycosyltransferase 36 associated
EY643_RS17710	COG3265	gluconokinase activity
EY643_RS17760	COG2193	ferroxidase activity
EY643_RS17815	COG0659	secondary active sulfate transmembrane transporter activity
EY643_RS17830	COG1234	tRNA 3'-trailer cleavage
EY643_RS17840	COG4783	chaperone-mediated protein folding
EY643_RS17860	COG0372	Belongs to the citrate synthase family
EY643_RS17870	COG1131	(ABC) transporter
EY643_RS17875	COG0842	Transport permease protein
EY643_RS17905	COG1522	sequence-specific DNA binding
EY643_RS17930	COG4166	transmembrane transport
EY643_RS17935	COG4166	transmembrane transport
EY643_RS17945	COG0601	transmembrane transport
EY643_RS17950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EY643_RS17955	COG4172	Belongs to the ABC transporter superfamily
EY643_RS17985	COG1228	amidohydrolase
EY643_RS18005	COG0745	RESPONSE REGULATOR receiver
EY643_RS18015	COG0483	inositol monophosphate 1-phosphatase activity
EY643_RS18020	COG0405	Gamma-glutamyltransferase
EY643_RS18030	COG0318	PFAM AMP-dependent synthetase and ligase
EY643_RS18050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EY643_RS18055	COG0363	glucosamine-6-phosphate deaminase activity
EY643_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
EY643_RS18125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EY643_RS18135	COG2124	cytochrome p450
EY643_RS18150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EY643_RS18165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EY643_RS18195	COG1858	cytochrome C peroxidase
EY643_RS18210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EY643_RS18225	COG1131	(ABC) transporter
EY643_RS18245	COG0583	DNA-binding transcription factor activity
EY643_RS18285	COG4771	TonB-dependent receptor
EY643_RS18295	COG0786	glutamate:sodium symporter activity
EY643_RS18325	COG0596	Alpha beta hydrolase
EY643_RS18335	COG4774	siderophore transport
EY643_RS18340	COG4145	pantothenate transmembrane transporter activity
EY643_RS18395	COG0584	glycerophosphoryl diester phosphodiesterase
EY643_RS18400	COG0469	pyruvate kinase activity
EY643_RS18405	COG0837	glucose binding
EY643_RS18410	COG0642	Histidine kinase
EY643_RS18415	COG0745	RESPONSE REGULATOR receiver
EY643_RS18420	COG1278	Cold shock
EY643_RS18435	COG0848	biopolymer transport protein
EY643_RS18440	COG0848	biopolymer transport protein
EY643_RS18445	COG0811	peptide transport
EY643_RS18450	COG0811	peptide transport
EY643_RS18465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EY643_RS18470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EY643_RS18485	COG0494	nUDIX hydrolase
EY643_RS18500	COG0509	glycine decarboxylation via glycine cleavage system
EY643_RS18505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EY643_RS18510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EY643_RS18515	COG0006	proline dipeptidase activity
EY643_RS18520	COG3079	Belongs to the UPF0149 family
EY643_RS18540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EY643_RS18550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EY643_RS18555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EY643_RS18565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EY643_RS18575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EY643_RS18580	COG0493	'glutamate synthase
EY643_RS18585	COG0067	glutamate synthase
EY643_RS18585	COG0069	glutamate synthase activity
EY643_RS18585	COG0070	glutamate synthase
EY643_RS18595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EY643_RS18630	COG0281	malic enzyme
EY643_RS18635	COG1525	nuclease
EY643_RS18645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EY643_RS18650	COG0018	arginyl-trna synthetase
EY643_RS18660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EY643_RS18665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EY643_RS18675	COG2226	methyltransferase
EY643_RS18685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EY643_RS18690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EY643_RS18695	COG0140	phosphoribosyl-ATP diphosphatase activity
EY643_RS18700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EY643_RS18705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EY643_RS18715	COG0668	transmembrane transport
EY643_RS18720	COG1132	(ABC) transporter
EY643_RS18730	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EY643_RS18755	COG2133	pyrroloquinoline quinone binding
EY643_RS18770	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EY643_RS18775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EY643_RS18785	COG3830	Belongs to the UPF0237 family
EY643_RS18785	COG0560	Phosphoserine phosphatase
EY643_RS18810	COG1490	D-aminoacyl-tRNA deacylase activity
EY643_RS18820	COG0301	tRNA thio-modification
EY643_RS18820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EY643_RS18825	COG0174	glutamine synthetase
EY643_RS18835	COG3852	Histidine kinase
EY643_RS18840	COG2204	response regulator
EY643_RS18845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EY643_RS18850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EY643_RS18870	COG4942	peptidase
EY643_RS18875	COG0793	Belongs to the peptidase S41A family
EY643_RS18885	COG0107	imidazoleglycerol-phosphate synthase activity
EY643_RS18890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EY643_RS18895	COG0131	Imidazoleglycerol-phosphate dehydratase
EY643_RS18905	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EY643_RS18940	COG0596	Alpha beta hydrolase
EY643_RS18950	COG1473	amidohydrolase
EY643_RS18965	COG0709	Synthesizes selenophosphate from selenide and ATP
EY643_RS18970	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EY643_RS18975	COG2974	May be involved in recombination
EY643_RS18980	COG3976	FMN-binding domain protein
EY643_RS18980	COG1053	succinate dehydrogenase
EY643_RS18995	COG1366	Belongs to the anti-sigma-factor antagonist family
EY643_RS19000	COG0519	Catalyzes the synthesis of GMP from XMP
EY643_RS19000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EY643_RS19030	COG0126	phosphoglycerate kinase activity
EY643_RS19035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EY643_RS19050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EY643_RS19055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EY643_RS19065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EY643_RS19070	COG3659	wide pore channel activity
EY643_RS19080	COG0189	ligase activity
EY643_RS19090	COG1678	Uncharacterized ACR, COG1678
EY643_RS19095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EY643_RS19125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EY643_RS19130	COG2813	Specifically methylates the guanine in position
EY643_RS19130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EY643_RS19140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EY643_RS19145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EY643_RS19150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EY643_RS19155	COG2363	Small membrane protein
EY643_RS19165	COG2177	Part of the ABC transporter FtsEX involved in
EY643_RS19170	COG2884	Cell division ATP-binding protein ftsE
EY643_RS19175	COG0552	protein localization to endoplasmic reticulum
EY643_RS19180	COG0742	ribosomal rna small subunit methyltransferase
EY643_RS19185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EY643_RS19195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EY643_RS19200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EY643_RS19205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EY643_RS19210	COG2003	Belongs to the UPF0758 family
EY643_RS19215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EY643_RS19225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EY643_RS19230	COG1309	transcriptional regulator
EY643_RS19240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EY643_RS19250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EY643_RS19255	COG1561	YicC-like family, N-terminal region
EY643_RS19260	COG0194	GDP metabolic process
EY643_RS19265	COG1758	RNA polymerase activity
EY643_RS19270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EY643_RS19280	COG0583	DNA-binding transcription factor activity
EY643_RS19285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EY643_RS19295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EY643_RS19305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EY643_RS19320	COG3022	response to hydroperoxide
EY643_RS19330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EY643_RS19340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EY643_RS19345	COG0210	DNA helicase
EY643_RS19370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EY643_RS19375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EY643_RS19390	COG2957	Belongs to the agmatine deiminase family
EY643_RS19410	COG1215	transferase activity, transferring glycosyl groups
EY643_RS19415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EY643_RS19420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EY643_RS19445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EY643_RS19450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EY643_RS19455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EY643_RS19460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EY643_RS19465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EY643_RS19470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EY643_RS19480	COG0356	it plays a direct role in the translocation of protons across the membrane
EY643_RS19490	COG1475	DNA binding
EY643_RS19495	COG1192	Involved in chromosome partitioning
EY643_RS19505	COG0445	tRNA wobble uridine modification
EY643_RS19515	COG2267	carboxylic ester hydrolase activity
EY643_RS19525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EY643_RS19535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EY643_RS19540	COG0706	membrane insertase activity
EY643_RS19545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EY643_RS19550	COG0594	ribonuclease P activity
EY643_RS19555	COG0230	Belongs to the bacterial ribosomal protein bL34 family