locus-tag	class	description
GKS42_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GKS42_RS00010	COG0592	DNA-directed DNA polymerase activity
GKS42_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GKS42_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKS42_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GKS42_RS00030	COG0187	DNA topoisomerase II activity
GKS42_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GKS42_RS00065	COG1289	transmembrane transporter activity
GKS42_RS00075	COG0018	arginyl-trna synthetase
GKS42_RS00105	COG3764	Sortase (surface protein transpeptidase)
GKS42_RS00115	COG0515	serine threonine protein kinase
GKS42_RS00120	COG0515	serine threonine protein kinase
GKS42_RS00125	COG0768	penicillin binding
GKS42_RS00140	COG1716	ATPase activity
GKS42_RS00145	COG1716	ATPase activity
GKS42_RS00160	COG1609	Transcriptional regulator
GKS42_RS00170	COG3458	cephalosporin-C deacetylase activity
GKS42_RS00195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GKS42_RS00205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GKS42_RS00210	COG1609	Transcriptional regulator
GKS42_RS00225	COG0395	ABC-type sugar transport system, permease component
GKS42_RS00235	COG1940	carbohydrate kinase activity
GKS42_RS00240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GKS42_RS00245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GKS42_RS00245	COG1796	DNA polymerase
GKS42_RS00250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKS42_RS00250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKS42_RS00285	COG0277	FAD linked oxidase domain protein
GKS42_RS00295	COG0588	phosphoglycerate mutase activity
GKS42_RS00325	COG0395	ABC-type sugar transport system, permease component
GKS42_RS00330	COG1175	transmembrane transport
GKS42_RS00340	COG1609	Transcriptional regulator
GKS42_RS00345	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GKS42_RS00360	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS00370	COG1794	racemase activity, acting on amino acids and derivatives
GKS42_RS00385	COG1780	Probably involved in ribonucleotide reductase function
GKS42_RS00390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKS42_RS00395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKS42_RS00405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKS42_RS00420	COG0579	oxidoreductase
GKS42_RS00430	COG1757	Na H antiporter
GKS42_RS00440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS00455	COG2116	formate transmembrane transporter activity
GKS42_RS00485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKS42_RS00490	COG0477	Major facilitator Superfamily
GKS42_RS00510	COG0667	Aldo Keto reductase
GKS42_RS00525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS00545	COG0583	DNA-binding transcription factor activity
GKS42_RS00560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GKS42_RS00570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKS42_RS00575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKS42_RS00590	COG1338	Plays a role in the flagellum-specific transport system
GKS42_RS00650	COG1157	protein secretion by the type III secretion system
GKS42_RS00660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GKS42_RS00665	COG1766	The M ring may be actively involved in energy transduction
GKS42_RS00670	COG1677	Flagellar hook-basal body complex protein FliE
GKS42_RS00680	COG1815	bacterial-type flagellum-dependent cell motility
GKS42_RS00695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GKS42_RS00700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GKS42_RS00715	COG1256	bacterial-type flagellum assembly
GKS42_RS00715	COG4786	Flagellar basal body rod
GKS42_RS00725	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GKS42_RS00755	COG0363	glucosamine-6-phosphate deaminase activity
GKS42_RS00770	COG1609	Transcriptional regulator
GKS42_RS00775	COG0673	inositol 2-dehydrogenase activity
GKS42_RS00780	COG0747	negative chemotaxis
GKS42_RS00785	COG0601	transmembrane transport
GKS42_RS00795	COG4172	Belongs to the ABC transporter superfamily
GKS42_RS00805	COG0673	inositol 2-dehydrogenase activity
GKS42_RS00810	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GKS42_RS00815	COG1846	Transcriptional regulator
GKS42_RS00815	COG1940	carbohydrate kinase activity
GKS42_RS00830	COG0395	ABC-type sugar transport system, permease component
GKS42_RS00835	COG1653	transport
GKS42_RS00840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKS42_RS00895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKS42_RS00895	COG0574	Belongs to the PEP-utilizing enzyme family
GKS42_RS00920	COG1803	Methylglyoxal synthase
GKS42_RS00940	COG1653	transport
GKS42_RS00990	COG0445	tRNA wobble uridine modification
GKS42_RS01010	COG1940	carbohydrate kinase activity
GKS42_RS01025	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01045	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01060	COG0277	FAD linked oxidase domain protein
GKS42_RS01075	COG1175	transmembrane transport
GKS42_RS01090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKS42_RS01105	COG1643	Atp-dependent helicase
GKS42_RS01150	COG0222	ribosome binding
GKS42_RS01215	COG4209	transmembrane transport
GKS42_RS01220	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01230	COG1609	Transcriptional regulator
GKS42_RS01235	COG2814	Major facilitator Superfamily
GKS42_RS01245	COG4585	Histidine kinase
GKS42_RS01250	COG2197	response regulator
GKS42_RS01270	COG1024	Enoyl-CoA hydratase
GKS42_RS01280	COG0372	Belongs to the citrate synthase family
GKS42_RS01285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKS42_RS01300	COG1129	ABC transporter
GKS42_RS01300	COG0842	Transport permease protein
GKS42_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS01340	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GKS42_RS01345	COG1414	Transcriptional regulator
GKS42_RS01360	COG1917	Cupin 2, conserved barrel domain protein
GKS42_RS01370	COG0456	acetyltransferase
GKS42_RS01400	COG1725	Transcriptional regulator
GKS42_RS01430	COG2197	response regulator
GKS42_RS01435	COG4585	Histidine kinase
GKS42_RS01440	COG3104	oligopeptide transport
GKS42_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
GKS42_RS01480	COG0673	inositol 2-dehydrogenase activity
GKS42_RS01485	COG0673	inositol 2-dehydrogenase activity
GKS42_RS01490	COG0673	inositol 2-dehydrogenase activity
GKS42_RS01495	COG1609	Transcriptional regulator
GKS42_RS01500	COG0363	glucosamine-6-phosphate deaminase activity
GKS42_RS01530	COG0604	alcohol dehydrogenase
GKS42_RS01535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKS42_RS01540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKS42_RS01555	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS01585	COG1175	transmembrane transport
GKS42_RS01590	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01595	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS01620	COG3458	cephalosporin-C deacetylase activity
GKS42_RS01645	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01650	COG1175	transmembrane transport
GKS42_RS01660	COG0445	tRNA wobble uridine modification
GKS42_RS01685	COG1132	(ABC) transporter
GKS42_RS01690	COG3250	beta-galactosidase activity
GKS42_RS01725	COG2902	Dehydrogenase
GKS42_RS01730	COG2353	YceI-like domain
GKS42_RS01740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS01760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS01800	COG1120	ATPase activity
GKS42_RS01805	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS01810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS01820	COG4592	Periplasmic binding protein
GKS42_RS01830	COG2357	RelA SpoT domain protein
GKS42_RS01840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GKS42_RS01860	COG2186	Transcriptional regulator
GKS42_RS01880	COG4209	transmembrane transport
GKS42_RS01885	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01905	COG1132	(ABC) transporter
GKS42_RS01945	COG0395	ABC-type sugar transport system, permease component
GKS42_RS01950	COG1175	transmembrane transport
GKS42_RS01965	COG1609	Transcriptional regulator
GKS42_RS01980	COG0662	Cupin 2, conserved barrel domain protein
GKS42_RS01985	COG2197	response regulator
GKS42_RS01990	COG4585	Histidine kinase
GKS42_RS01995	COG0842	Transport permease protein
GKS42_RS02000	COG1131	(ABC) transporter
GKS42_RS02020	COG2409	Drug exporters of the RND superfamily
GKS42_RS02030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKS42_RS02035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKS42_RS02050	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS02055	COG3833	ABC-type maltose transport systems, permease component
GKS42_RS02060	COG1175	transmembrane transport
GKS42_RS02075	COG4106	trans-aconitate 2-methyltransferase activity
GKS42_RS02100	COG0076	glutamate decarboxylase activity
GKS42_RS02140	COG1132	(ABC) transporter
GKS42_RS02155	COG1609	Transcriptional regulator
GKS42_RS02170	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02180	COG0673	inositol 2-dehydrogenase activity
GKS42_RS02195	COG0402	S-adenosylhomocysteine deaminase activity
GKS42_RS02210	COG0656	L-ascorbic acid biosynthetic process
GKS42_RS02215	COG1175	transmembrane transport
GKS42_RS02220	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS02245	COG2376	Dihydroxyacetone kinase
GKS42_RS02250	COG0698	ribose 5-phosphate isomerase
GKS42_RS02255	COG0149	triose-phosphate isomerase activity
GKS42_RS02270	COG2337	Toxic component of a toxin-antitoxin (TA) module
GKS42_RS02290	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02295	COG1175	transmembrane transport
GKS42_RS02305	COG1609	Transcriptional regulator
GKS42_RS02335	COG0277	FAD linked oxidase domain protein
GKS42_RS02345	COG0698	ribose 5-phosphate isomerase
GKS42_RS02360	COG1609	Transcriptional regulator
GKS42_RS02370	COG1024	Enoyl-CoA hydratase
GKS42_RS02400	COG1454	alcohol dehydrogenase
GKS42_RS02405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GKS42_RS02410	COG1414	Transcriptional regulator
GKS42_RS02415	COG1175	transmembrane transport
GKS42_RS02420	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02425	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS02435	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS02445	COG0702	epimerase
GKS42_RS02455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GKS42_RS02465	COG1136	(ABC) transporter
GKS42_RS02465	COG0577	efflux transmembrane transporter activity
GKS42_RS02470	COG1309	transcriptional regulator
GKS42_RS02475	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GKS42_RS02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GKS42_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS02510	COG1063	alcohol dehydrogenase
GKS42_RS02515	COG2186	Transcriptional regulator
GKS42_RS02520	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS02525	COG2186	Transcriptional regulator
GKS42_RS02540	COG1285	pathogenesis
GKS42_RS02555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GKS42_RS02560	COG0569	domain protein
GKS42_RS02610	COG2885	chlorophyll binding
GKS42_RS02670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GKS42_RS02710	COG1228	amidohydrolase
GKS42_RS02715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GKS42_RS02725	COG2986	histidine ammonia-lyase
GKS42_RS02730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GKS42_RS02750	COG4941	Belongs to the sigma-70 factor family
GKS42_RS02755	COG2226	methyltransferase
GKS42_RS02775	COG0010	Belongs to the arginase family
GKS42_RS02800	COG0346	lactoylglutathione lyase activity
GKS42_RS02820	COG0640	Transcriptional regulator
GKS42_RS02845	COG1175	transmembrane transport
GKS42_RS02850	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02855	COG0445	tRNA wobble uridine modification
GKS42_RS02895	COG4585	Histidine kinase
GKS42_RS02915	COG1609	Transcriptional regulator
GKS42_RS02925	COG1175	transmembrane transport
GKS42_RS02930	COG0395	ABC-type sugar transport system, permease component
GKS42_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS02975	COG2186	Transcriptional regulator
GKS42_RS02980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKS42_RS02990	COG1175	transmembrane transport
GKS42_RS02995	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKS42_RS03010	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS03020	COG1609	Transcriptional regulator
GKS42_RS03025	COG2197	response regulator
GKS42_RS03030	COG4585	Histidine kinase
GKS42_RS03045	COG1131	(ABC) transporter
GKS42_RS03050	COG2267	carboxylic ester hydrolase activity
GKS42_RS03065	COG1473	amidohydrolase
GKS42_RS03070	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS03075	COG1653	transport
GKS42_RS03080	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03090	COG1349	DNA-binding transcription factor activity
GKS42_RS03095	COG0402	S-adenosylhomocysteine deaminase activity
GKS42_RS03120	COG3959	Transketolase, thiamine diphosphate binding domain
GKS42_RS03125	COG3958	Transketolase
GKS42_RS03130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GKS42_RS03145	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS03160	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03165	COG1175	transmembrane transport
GKS42_RS03180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GKS42_RS03185	COG1082	Xylose isomerase domain protein TIM barrel
GKS42_RS03215	COG1609	Transcriptional regulator
GKS42_RS03225	COG3618	amidohydrolase
GKS42_RS03250	COG4209	transmembrane transport
GKS42_RS03255	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03260	COG1653	transport
GKS42_RS03275	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03280	COG0667	Aldo Keto reductase
GKS42_RS03290	COG3250	beta-galactosidase activity
GKS42_RS03310	COG1850	ribulose-bisphosphate carboxylase activity
GKS42_RS03315	COG4677	pectinesterase activity
GKS42_RS03335	COG4608	Belongs to the ABC transporter superfamily
GKS42_RS03340	COG0444	Belongs to the ABC transporter superfamily
GKS42_RS03345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKS42_RS03375	COG0747	negative chemotaxis
GKS42_RS03380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GKS42_RS03390	COG1349	DNA-binding transcription factor activity
GKS42_RS03395	COG0656	L-ascorbic acid biosynthetic process
GKS42_RS03400	COG1609	Transcriptional regulator
GKS42_RS03405	COG3507	Belongs to the glycosyl hydrolase 43 family
GKS42_RS03415	COG1120	ATPase activity
GKS42_RS03420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS03425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS03440	COG1739	Uncharacterized protein family UPF0029
GKS42_RS03450	COG1175	transmembrane transport
GKS42_RS03480	COG4585	Histidine kinase
GKS42_RS03500	COG2814	Major facilitator Superfamily
GKS42_RS03550	COG1063	alcohol dehydrogenase
GKS42_RS03565	COG4067	protein conserved in archaea
GKS42_RS03565	COG0189	ligase activity
GKS42_RS03570	COG0189	ligase activity
GKS42_RS03570	COG0569	domain protein
GKS42_RS03575	COG0747	negative chemotaxis
GKS42_RS03580	COG0601	transmembrane transport
GKS42_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS03595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS03615	COG0673	inositol 2-dehydrogenase activity
GKS42_RS03625	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GKS42_RS03625	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GKS42_RS03640	COG3537	Alpha-1,2-mannosidase
GKS42_RS03660	COG1609	Transcriptional regulator
GKS42_RS03675	COG1414	Transcriptional regulator
GKS42_RS03690	COG0444	Belongs to the ABC transporter superfamily
GKS42_RS03695	COG4608	Belongs to the ABC transporter superfamily
GKS42_RS03705	COG0406	alpha-ribazole phosphatase activity
GKS42_RS03715	COG0747	negative chemotaxis
GKS42_RS03720	COG0371	Dehydrogenase
GKS42_RS03730	COG1397	ADP-ribosylglycohydrolase
GKS42_RS03735	COG1597	lipid kinase activity
GKS42_RS03755	COG3629	intracellular signal transduction
GKS42_RS03755	COG3903	Transcriptional regulator
GKS42_RS03780	COG0738	Major facilitator superfamily
GKS42_RS03790	COG3226	Transcriptional regulator
GKS42_RS03800	COG0028	Belongs to the TPP enzyme family
GKS42_RS03820	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKS42_RS03830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKS42_RS03840	COG1403	HNH endonuclease
GKS42_RS03850	COG0492	ferredoxin-NADP+ reductase activity
GKS42_RS03890	COG1674	ftsk spoiiie
GKS42_RS03900	COG0714	Associated with various cellular activities
GKS42_RS03915	COG4552	Acetyltransferase involved in intracellular survival and related
GKS42_RS03925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GKS42_RS03940	COG0395	ABC-type sugar transport system, permease component
GKS42_RS03945	COG1175	transmembrane transport
GKS42_RS03960	COG2084	Dehydrogenase
GKS42_RS03970	COG3622	Belongs to the hyi family
GKS42_RS03990	COG3119	arylsulfatase activity
GKS42_RS04000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKS42_RS04005	COG1331	Highly conserved protein containing a thioredoxin domain
GKS42_RS04050	COG1215	transferase activity, transferring glycosyl groups
GKS42_RS04060	COG1278	Cold shock
GKS42_RS04065	COG1597	lipid kinase activity
GKS42_RS04070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GKS42_RS04075	COG0561	phosphatase activity
GKS42_RS04085	COG1653	transport
GKS42_RS04090	COG1175	transmembrane transport
GKS42_RS04095	COG0395	ABC-type sugar transport system, permease component
GKS42_RS04110	COG3321	synthase
GKS42_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS04110	COG0604	alcohol dehydrogenase
GKS42_RS04115	COG0395	ABC-type sugar transport system, permease component
GKS42_RS04120	COG1175	transmembrane transport
GKS42_RS04160	COG1063	alcohol dehydrogenase
GKS42_RS04165	COG1309	transcriptional regulator
GKS42_RS04170	COG0667	Aldo Keto reductase
GKS42_RS04175	COG0484	heat shock protein binding
GKS42_RS04185	COG0789	Transcriptional regulator
GKS42_RS04240	COG1136	(ABC) transporter
GKS42_RS04260	COG2261	transglycosylase associated protein
GKS42_RS04275	COG2807	transmembrane transport
GKS42_RS04285	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS04315	COG4941	Belongs to the sigma-70 factor family
GKS42_RS04320	COG3795	YCII-related domain
GKS42_RS04325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GKS42_RS04360	COG0577	efflux transmembrane transporter activity
GKS42_RS04360	COG1136	(ABC) transporter
GKS42_RS04410	COG1335	isochorismatase
GKS42_RS04430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKS42_RS04435	COG0402	S-adenosylhomocysteine deaminase activity
GKS42_RS04445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKS42_RS04475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GKS42_RS04480	COG0402	S-adenosylhomocysteine deaminase activity
GKS42_RS04495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKS42_RS04505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GKS42_RS04510	COG2011	ABC-type metal ion transport system permease component
GKS42_RS04515	COG1464	Belongs to the NlpA lipoprotein family
GKS42_RS04570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GKS42_RS04575	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GKS42_RS04575	COG1672	PFAM Archaeal ATPase
GKS42_RS04600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GKS42_RS04650	COG0673	inositol 2-dehydrogenase activity
GKS42_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS04685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GKS42_RS04690	COG2072	flavoprotein involved in K transport
GKS42_RS04735	COG0673	inositol 2-dehydrogenase activity
GKS42_RS04745	COG1609	Transcriptional regulator
GKS42_RS04765	COG1940	carbohydrate kinase activity
GKS42_RS04770	COG2115	Belongs to the xylose isomerase family
GKS42_RS04775	COG1070	Carbohydrate kinase
GKS42_RS04790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GKS42_RS04795	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS04805	COG2084	Dehydrogenase
GKS42_RS04820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GKS42_RS04825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GKS42_RS04830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GKS42_RS04840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GKS42_RS04870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GKS42_RS04875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GKS42_RS04880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKS42_RS04890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GKS42_RS04895	COG0569	domain protein
GKS42_RS04900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GKS42_RS04905	COG0123	including yeast histone deacetylase and acetoin utilization protein
GKS42_RS04930	COG2353	YceI-like domain
GKS42_RS04940	COG0406	alpha-ribazole phosphatase activity
GKS42_RS04960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKS42_RS04995	COG0025	NhaP-type Na H and K H
GKS42_RS05005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GKS42_RS05010	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS05015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GKS42_RS05020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKS42_RS05025	COG1169	isochorismate synthase
GKS42_RS05030	COG2226	methyltransferase
GKS42_RS05045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKS42_RS05050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKS42_RS05055	COG0649	NAD binding
GKS42_RS05065	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GKS42_RS05070	COG1034	ATP synthesis coupled electron transport
GKS42_RS05075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKS42_RS05080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKS42_RS05090	COG0713	ATP synthesis coupled electron transport
GKS42_RS05095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKS42_RS05105	COG1007	ATP synthesis coupled electron transport
GKS42_RS05115	COG1674	ftsk spoiiie
GKS42_RS05135	COG1404	Belongs to the peptidase S8 family
GKS42_RS05165	COG1404	Belongs to the peptidase S8 family
GKS42_RS05185	COG0501	Belongs to the peptidase M48B family
GKS42_RS05190	COG1666	GTP binding
GKS42_RS05210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKS42_RS05215	COG2030	dehydratase
GKS42_RS05225	COG1609	Transcriptional regulator
GKS42_RS05230	COG0738	Major facilitator superfamily
GKS42_RS05235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GKS42_RS05245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GKS42_RS05275	COG0745	RESPONSE REGULATOR receiver
GKS42_RS05280	COG2205	protein histidine kinase activity
GKS42_RS05300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKS42_RS05305	COG0081	regulation of translation
GKS42_RS05310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GKS42_RS05315	COG0222	ribosome binding
GKS42_RS05320	COG0085	RNA polymerase activity
GKS42_RS05325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKS42_RS05335	COG1131	(ABC) transporter
GKS42_RS05360	COG2211	Major facilitator Superfamily
GKS42_RS05365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKS42_RS05370	COG0049	tRNA binding
GKS42_RS05375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKS42_RS05380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GKS42_RS05390	COG0051	transcription antitermination factor activity, RNA binding
GKS42_RS05395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKS42_RS05400	COG0088	Forms part of the polypeptide exit tunnel
GKS42_RS05405	COG0089	rRNA binding
GKS42_RS05410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GKS42_RS05415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GKS42_RS05420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GKS42_RS05425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GKS42_RS05430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKS42_RS05435	COG0255	Belongs to the universal ribosomal protein uL29 family
GKS42_RS05440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKS42_RS05445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKS42_RS05450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GKS42_RS05455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GKS42_RS05460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKS42_RS05465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GKS42_RS05470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GKS42_RS05480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKS42_RS05485	COG1841	ribosomal large subunit assembly
GKS42_RS05490	COG0200	Binds to the 23S rRNA
GKS42_RS05495	COG0201	protein transport
GKS42_RS05500	COG0563	adenylate kinase activity
GKS42_RS05510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKS42_RS05515	COG1218	3'(2'),5'-bisphosphate nucleotidase
GKS42_RS05520	COG2909	trisaccharide binding
GKS42_RS05530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKS42_RS05535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKS42_RS05540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKS42_RS05545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKS42_RS05550	COG0202	RNA polymerase activity
GKS42_RS05555	COG0203	ribosomal protein L17
GKS42_RS05560	COG2267	carboxylic ester hydrolase activity
GKS42_RS05570	COG0101	tRNA pseudouridine synthase activity
GKS42_RS05580	COG0488	(ABC) transporter
GKS42_RS05585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GKS42_RS05590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKS42_RS05595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKS42_RS05600	COG0242	peptide deformylase activity
GKS42_RS05640	COG1072	(Pantothenic acid kinase))
GKS42_RS05645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKS42_RS05650	COG0736	holo-[acyl-carrier-protein] synthase activity
GKS42_RS05670	COG1214	PFAM Peptidase M22, glycoprotease
GKS42_RS05670	COG0456	acetyltransferase
GKS42_RS05685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKS42_RS05700	COG1695	Transcriptional regulator
GKS42_RS05710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKS42_RS05725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKS42_RS05755	COG0516	GMP reductase activity
GKS42_RS05775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GKS42_RS05780	COG1609	Transcriptional regulator
GKS42_RS05790	COG1175	transmembrane transport
GKS42_RS05795	COG0395	ABC-type sugar transport system, permease component
GKS42_RS05815	COG0114	fumarate hydratase activity
GKS42_RS05830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GKS42_RS05850	COG1132	(ABC) transporter
GKS42_RS05855	COG1132	(ABC) transporter
GKS42_RS05870	COG0519	Catalyzes the synthesis of GMP from XMP
GKS42_RS05870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKS42_RS05875	COG4106	trans-aconitate 2-methyltransferase activity
GKS42_RS05900	COG2197	response regulator
GKS42_RS05905	COG0702	epimerase
GKS42_RS05915	COG0667	Aldo Keto reductase
GKS42_RS05920	COG0789	Transcriptional regulator
GKS42_RS05955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GKS42_RS05955	COG2755	lipolytic protein G-D-S-L family
GKS42_RS05960	COG0045	succinate-CoA ligase (ADP-forming) activity
GKS42_RS05995	COG0138	bifunctional purine biosynthesis protein purh
GKS42_RS06025	COG0039	L-malate dehydrogenase activity
GKS42_RS06055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GKS42_RS06060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKS42_RS06070	COG0708	Exodeoxyribonuclease III
GKS42_RS06090	COG0577	efflux transmembrane transporter activity
GKS42_RS06095	COG1136	(ABC) transporter
GKS42_RS06095	COG0577	efflux transmembrane transporter activity
GKS42_RS06125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GKS42_RS06155	COG1175	transmembrane transport
GKS42_RS06165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS06170	COG1609	Transcriptional regulator
GKS42_RS06175	COG1473	amidohydrolase
GKS42_RS06175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKS42_RS06180	COG1744	ABC transporter substrate-binding protein PnrA-like
GKS42_RS06225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GKS42_RS06240	COG0765	amino acid transport
GKS42_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
GKS42_RS06275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GKS42_RS06290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKS42_RS06335	COG0477	Major facilitator Superfamily
GKS42_RS06345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKS42_RS06350	COG1611	Belongs to the LOG family
GKS42_RS06365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKS42_RS06370	COG4122	O-methyltransferase activity
GKS42_RS06380	COG1595	DNA-templated transcription, initiation
GKS42_RS06390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKS42_RS06395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKS42_RS06400	COG0489	protein tyrosine kinase activity
GKS42_RS06400	COG2151	metal-sulfur cluster biosynthetic enzyme
GKS42_RS06410	COG2239	Acts as a magnesium transporter
GKS42_RS06425	COG0006	proline dipeptidase activity
GKS42_RS06430	COG0613	PHP domain protein
GKS42_RS06435	COG2095	MarC family integral membrane protein
GKS42_RS06440	COG0513	Belongs to the DEAD box helicase family
GKS42_RS06465	COG0210	DNA helicase
GKS42_RS06475	COG2816	NAD+ diphosphatase activity
GKS42_RS06520	COG1615	UPF0182 protein
GKS42_RS06545	COG0277	FAD linked oxidase domain protein
GKS42_RS06560	COG0714	Associated with various cellular activities
GKS42_RS06580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GKS42_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
GKS42_RS06625	COG0494	nUDIX hydrolase
GKS42_RS06630	COG1131	(ABC) transporter
GKS42_RS06645	COG1063	alcohol dehydrogenase
GKS42_RS06685	COG0395	ABC-type sugar transport system, permease component
GKS42_RS06720	COG1674	ftsk spoiiie
GKS42_RS06735	COG0514	ATP-dependent DNA helicase (RecQ)
GKS42_RS06750	COG1136	(ABC) transporter
GKS42_RS06750	COG0577	efflux transmembrane transporter activity
GKS42_RS06755	COG2197	response regulator
GKS42_RS06765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS06770	COG2135	peptidase activity
GKS42_RS06795	COG0395	ABC-type sugar transport system, permease component
GKS42_RS06810	COG0395	ABC-type sugar transport system, permease component
GKS42_RS06825	COG1609	Transcriptional regulator
GKS42_RS06830	COG1621	beta-fructofuranosidase activity
GKS42_RS06835	COG0395	ABC-type sugar transport system, permease component
GKS42_RS06840	COG1175	transmembrane transport
GKS42_RS06895	COG2211	Major facilitator Superfamily
GKS42_RS06900	COG1126	abc transporter atp-binding protein
GKS42_RS06905	COG0765	amino acid transport
GKS42_RS06910	COG0765	amino acid transport
GKS42_RS06925	COG2814	Major facilitator Superfamily
GKS42_RS06930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GKS42_RS06935	COG1012	belongs to the aldehyde dehydrogenase family
GKS42_RS06950	COG4106	trans-aconitate 2-methyltransferase activity
GKS42_RS06960	COG0596	Alpha beta hydrolase
GKS42_RS06975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GKS42_RS06980	COG2884	Cell division ATP-binding protein ftsE
GKS42_RS06985	COG2177	Part of the ABC transporter FtsEX involved in
GKS42_RS06995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKS42_RS07045	COG1204	response to ionizing radiation
GKS42_RS07170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GKS42_RS07330	COG0084	hydrolase, TatD family'
GKS42_RS07350	COG5434	Belongs to the glycosyl hydrolase 28 family
GKS42_RS07365	COG0640	Transcriptional regulator
GKS42_RS07370	COG1124	(ABC) transporter
GKS42_RS07375	COG0395	ABC-type sugar transport system, permease component
GKS42_RS07380	COG1175	transmembrane transport
GKS42_RS07435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GKS42_RS07455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GKS42_RS07460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS07465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GKS42_RS07470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GKS42_RS07530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKS42_RS07545	COG0386	Belongs to the glutathione peroxidase family
GKS42_RS07690	COG1196	nuclear chromosome segregation
GKS42_RS07690	COG0739	heme binding
GKS42_RS07690	COG0741	lytic transglycosylase activity
GKS42_RS07835	COG0741	lytic transglycosylase activity
GKS42_RS07835	COG1196	nuclear chromosome segregation
GKS42_RS07835	COG0739	heme binding
GKS42_RS07855	COG4974	Belongs to the 'phage' integrase family
GKS42_RS07900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GKS42_RS07945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS07955	COG1120	ATPase activity
GKS42_RS07985	COG1764	response to oxidative stress
GKS42_RS08030	COG2072	flavoprotein involved in K transport
GKS42_RS08055	COG2182	Extracellular solute-binding protein
GKS42_RS08065	COG0395	ABC-type sugar transport system, permease component
GKS42_RS08070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GKS42_RS08075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GKS42_RS08080	COG1737	Transcriptional regulator
GKS42_RS08090	COG1609	Transcriptional regulator
GKS42_RS08105	COG0395	ABC-type sugar transport system, permease component
GKS42_RS08110	COG1175	transmembrane transport
GKS42_RS08125	COG1946	Acyl-CoA thioesterase
GKS42_RS08135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKS42_RS08140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GKS42_RS08145	COG0668	transmembrane transport
GKS42_RS08155	COG2190	(PTS) system
GKS42_RS08165	COG0384	phenazine biosynthesis protein PhzF
GKS42_RS08180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GKS42_RS08205	COG3590	peptidase
GKS42_RS08215	COG0698	ribose 5-phosphate isomerase
GKS42_RS08235	COG1045	serine acetyltransferase
GKS42_RS08265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKS42_RS08270	COG0254	rRNA binding
GKS42_RS08330	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKS42_RS08340	COG0740	serine-type endopeptidase activity
GKS42_RS08345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GKS42_RS08360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS08365	COG0444	Belongs to the ABC transporter superfamily
GKS42_RS08375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS08485	COG1605	Chorismate mutase
GKS42_RS08485	COG0287	Prephenate dehydrogenase
GKS42_RS08490	COG2223	nitrite transmembrane transporter activity
GKS42_RS08495	COG0243	molybdopterin cofactor binding
GKS42_RS08500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKS42_RS08505	COG2146	nitrite reductase [NAD(P)H] activity
GKS42_RS08505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKS42_RS08510	COG2146	nitrite reductase [NAD(P)H] activity
GKS42_RS08510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKS42_RS08535	COG1648	precorrin-2 dehydrogenase activity
GKS42_RS08535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKS42_RS08540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS08550	COG3467	pyridoxamine 5'-phosphate
GKS42_RS08575	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKS42_RS08600	COG0525	valine-tRNA ligase activity
GKS42_RS08610	COG0395	ABC-type sugar transport system, permease component
GKS42_RS08615	COG1175	transmembrane transport
GKS42_RS08625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS08630	COG1486	melibiose metabolic process
GKS42_RS08640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKS42_RS08645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS08665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKS42_RS08670	COG1120	ATPase activity
GKS42_RS08675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS08710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKS42_RS08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKS42_RS08725	COG1116	anion transmembrane transporter activity
GKS42_RS08730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKS42_RS08735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GKS42_RS08750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKS42_RS08770	COG2197	response regulator
GKS42_RS08780	COG1960	acyl-CoA dehydrogenase activity
GKS42_RS08790	COG1846	Transcriptional regulator
GKS42_RS08795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKS42_RS08805	COG1733	regulation of RNA biosynthetic process
GKS42_RS08815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKS42_RS08830	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GKS42_RS08835	COG1063	alcohol dehydrogenase
GKS42_RS08870	COG4977	sequence-specific DNA binding
GKS42_RS08880	COG0300	oxidoreductase activity
GKS42_RS08900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GKS42_RS08905	COG0285	dihydrofolate synthase activity
GKS42_RS08915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GKS42_RS08950	COG1733	regulation of RNA biosynthetic process
GKS42_RS08965	COG2376	Dihydroxyacetone kinase
GKS42_RS08970	COG1461	Dihydroxyacetone kinase
GKS42_RS08975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GKS42_RS08990	COG0105	UTP biosynthetic process
GKS42_RS09005	COG1349	DNA-binding transcription factor activity
GKS42_RS09020	COG2197	response regulator
GKS42_RS09025	COG4585	Histidine kinase
GKS42_RS09030	COG1131	(ABC) transporter
GKS42_RS09040	COG1605	Chorismate mutase
GKS42_RS09040	COG0077	Prephenate dehydratase
GKS42_RS09060	COG1136	(ABC) transporter
GKS42_RS09080	COG3842	ATPase activity
GKS42_RS09085	COG0395	ABC-type sugar transport system, permease component
GKS42_RS09125	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GKS42_RS09145	COG1131	(ABC) transporter
GKS42_RS09155	COG1131	(ABC) transporter
GKS42_RS09165	COG0228	four-way junction DNA binding
GKS42_RS09170	COG1837	Belongs to the UPF0109 family
GKS42_RS09175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKS42_RS09180	COG0336	Belongs to the RNA methyltransferase TrmD family
GKS42_RS09185	COG0335	large ribosomal subunit rRNA binding
GKS42_RS09190	COG0681	Belongs to the peptidase S26 family
GKS42_RS09195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GKS42_RS09205	COG0792	nuclease activity
GKS42_RS09235	COG0052	Belongs to the universal ribosomal protein uS2 family
GKS42_RS09240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GKS42_RS09245	COG0528	UMP kinase activity
GKS42_RS09250	COG0233	cytoplasmic translational termination
GKS42_RS09255	COG0575	Belongs to the CDS family
GKS42_RS09265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKS42_RS09275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GKS42_RS09280	COG0750	zinc metalloprotease
GKS42_RS09285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GKS42_RS09295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKS42_RS09300	COG0442	prolyl-tRNA aminoacylation
GKS42_RS09310	COG0779	Required for maturation of 30S ribosomal subunits
GKS42_RS09325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GKS42_RS09330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GKS42_RS09335	COG0477	Major facilitator Superfamily
GKS42_RS09345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GKS42_RS09365	COG1695	Transcriptional regulator
GKS42_RS09370	COG0196	riboflavin kinase activity
GKS42_RS09375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKS42_RS09380	COG1185	polyribonucleotide nucleotidyltransferase activity
GKS42_RS09385	COG0612	Peptidase, M16
GKS42_RS09390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKS42_RS09410	COG1132	(ABC) transporter
GKS42_RS09425	COG4209	transmembrane transport
GKS42_RS09430	COG0395	ABC-type sugar transport system, permease component
GKS42_RS09440	COG0673	inositol 2-dehydrogenase activity
GKS42_RS09455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GKS42_RS09470	COG1674	ftsk spoiiie
GKS42_RS09480	COG3655	Transcriptional regulator
GKS42_RS09495	COG1058	Belongs to the CinA family
GKS42_RS09495	COG1546	Belongs to the CinA family
GKS42_RS09510	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS09515	COG1609	Transcriptional regulator
GKS42_RS09520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKS42_RS09525	COG1201	RNA secondary structure unwinding
GKS42_RS09540	COG0842	Transport permease protein
GKS42_RS09550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKS42_RS09560	COG1846	Transcriptional regulator
GKS42_RS09580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKS42_RS09585	COG0022	dehydrogenase e1 component
GKS42_RS09600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GKS42_RS09610	COG1175	transmembrane transport
GKS42_RS09620	COG1609	Transcriptional regulator
GKS42_RS09635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GKS42_RS09640	COG2137	regulation of response to DNA damage stimulus
GKS42_RS09650	COG0765	amino acid transport
GKS42_RS09655	COG0765	amino acid transport
GKS42_RS09660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GKS42_RS09665	COG1126	abc transporter atp-binding protein
GKS42_RS09670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKS42_RS09685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKS42_RS09690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GKS42_RS09695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKS42_RS09695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKS42_RS09700	COG2813	Specifically methylates the guanine in position
GKS42_RS09705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKS42_RS09740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKS42_RS09745	COG0667	Aldo Keto reductase
GKS42_RS09750	COG0563	adenylate kinase activity
GKS42_RS09765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKS42_RS09780	COG1278	Cold shock
GKS42_RS09795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKS42_RS09815	COG0714	Associated with various cellular activities
GKS42_RS09820	COG2001	Belongs to the MraZ family
GKS42_RS09825	COG0275	rRNA processing
GKS42_RS09835	COG0768	penicillin binding
GKS42_RS09840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKS42_RS09850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKS42_RS09855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GKS42_RS09865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKS42_RS09870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKS42_RS09880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GKS42_RS09890	COG1799	cell septum assembly
GKS42_RS09900	COG3599	regulation of cell shape
GKS42_RS09955	COG0587	DNA-directed DNA polymerase activity
GKS42_RS09975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKS42_RS10015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKS42_RS10020	COG0131	Imidazoleglycerol-phosphate dehydratase
GKS42_RS10030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GKS42_RS10035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKS42_RS10045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKS42_RS10050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKS42_RS10055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKS42_RS10060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKS42_RS10105	COG1435	thymidine kinase activity
GKS42_RS10125	COG1793	dna ligase
GKS42_RS10150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GKS42_RS10165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKS42_RS10170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS10175	COG0586	Pfam SNARE associated Golgi protein
GKS42_RS10180	COG2318	DinB family
GKS42_RS10195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKS42_RS10200	COG0072	phenylalanine-tRNA ligase activity
GKS42_RS10200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKS42_RS10250	COG0242	peptide deformylase activity
GKS42_RS10275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GKS42_RS10280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GKS42_RS10285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKS42_RS10290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKS42_RS10300	COG1438	arginine binding
GKS42_RS10305	COG0137	argininosuccinate synthase activity
GKS42_RS10310	COG0165	Argininosuccinate lyase
GKS42_RS10315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKS42_RS10315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKS42_RS10320	COG2094	Belongs to the DNA glycosylase MPG family
GKS42_RS10325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GKS42_RS10350	COG0647	UMP catabolic process
GKS42_RS10365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GKS42_RS10370	COG0497	DNA recombination
GKS42_RS10395	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS10400	COG0504	CTP synthase activity
GKS42_RS10405	COG0494	nUDIX hydrolase
GKS42_RS10410	COG1612	heme a metabolic process
GKS42_RS10435	COG0719	Fe-S assembly protein
GKS42_RS10445	COG0396	ATPase activity
GKS42_RS10455	COG0822	iron-sulfur transferase activity
GKS42_RS10460	COG2151	metal-sulfur cluster biosynthetic enzyme
GKS42_RS10475	COG0488	(ABC) transporter
GKS42_RS10480	COG0583	DNA-binding transcription factor activity
GKS42_RS10485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKS42_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS10525	COG0560	Phosphoserine phosphatase
GKS42_RS10525	COG3830	Belongs to the UPF0237 family
GKS42_RS10535	COG0297	glycogen (starch) synthase activity
GKS42_RS10545	COG1119	ATPase activity
GKS42_RS10570	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS10570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKS42_RS10590	COG0601	transmembrane transport
GKS42_RS10600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKS42_RS10605	COG1410	methionine synthase
GKS42_RS10605	COG0646	methionine synthase
GKS42_RS10610	COG1609	Transcriptional regulator
GKS42_RS10650	COG1881	PFAM PEBP family protein
GKS42_RS10670	COG4592	Periplasmic binding protein
GKS42_RS10675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS10680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS10685	COG1120	ATPase activity
GKS42_RS10705	COG0740	serine-type endopeptidase activity
GKS42_RS10710	COG0740	serine-type endopeptidase activity
GKS42_RS10720	COG0587	DNA-directed DNA polymerase activity
GKS42_RS10735	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GKS42_RS10745	COG1357	PFAM Pentapeptide repeats (8 copies)
GKS42_RS10755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GKS42_RS10770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GKS42_RS10800	COG1404	Belongs to the peptidase S8 family
GKS42_RS10805	COG0339	signal peptide processing
GKS42_RS10810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKS42_RS10825	COG0667	Aldo Keto reductase
GKS42_RS10830	COG1968	undecaprenyl-diphosphatase activity
GKS42_RS10835	COG0215	cysteine-tRNA ligase activity
GKS42_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKS42_RS10850	COG1994	Peptidase M50
GKS42_RS10850	COG0517	IMP dehydrogenase activity
GKS42_RS10860	COG1222	aaa ATPase
GKS42_RS10865	COG4122	O-methyltransferase activity
GKS42_RS10875	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKS42_RS10880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKS42_RS10885	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKS42_RS10895	COG0107	imidazoleglycerol-phosphate synthase activity
GKS42_RS10905	COG1132	(ABC) transporter
GKS42_RS10915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKS42_RS10945	COG0134	indole-3-glycerol-phosphate synthase activity
GKS42_RS10950	COG0133	tryptophan synthase activity
GKS42_RS10955	COG0159	tryptophan synthase activity
GKS42_RS10960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GKS42_RS10965	COG0070	glutamate synthase
GKS42_RS10965	COG0067	glutamate synthase
GKS42_RS10965	COG0069	glutamate synthase activity
GKS42_RS11090	COG1309	transcriptional regulator
GKS42_RS11095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKS42_RS11100	COG1414	Transcriptional regulator
GKS42_RS11105	COG1414	Transcriptional regulator
GKS42_RS11110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GKS42_RS11115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GKS42_RS11125	COG1454	alcohol dehydrogenase
GKS42_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
GKS42_RS11130	COG0372	Belongs to the citrate synthase family
GKS42_RS11135	COG0028	Belongs to the TPP enzyme family
GKS42_RS11160	COG2050	protein possibly involved in aromatic compounds catabolism
GKS42_RS11180	COG0539	negative regulation of cytoplasmic translation
GKS42_RS11185	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GKS42_RS11190	COG0237	dephospho-CoA kinase activity
GKS42_RS11190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GKS42_RS11205	COG1309	transcriptional regulator
GKS42_RS11210	COG1764	response to oxidative stress
GKS42_RS11220	COG0556	nucleotide-excision repair
GKS42_RS11235	COG1737	Transcriptional regulator
GKS42_RS11240	COG4821	SIS domain
GKS42_RS11245	COG1653	transport
GKS42_RS11250	COG1175	transmembrane transport
GKS42_RS11255	COG0395	ABC-type sugar transport system, permease component
GKS42_RS11260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKS42_RS11290	COG3387	PFAM Glycoside hydrolase 15-related
GKS42_RS11300	COG0431	NADPH-dependent FMN reductase
GKS42_RS11315	COG0322	excinuclease ABC activity
GKS42_RS11320	COG1660	Displays ATPase and GTPase activities
GKS42_RS11330	COG1481	regulation of sporulation
GKS42_RS11340	COG0126	phosphoglycerate kinase activity
GKS42_RS11345	COG0149	triose-phosphate isomerase activity
GKS42_RS11350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GKS42_RS11370	COG4122	O-methyltransferase activity
GKS42_RS11390	COG0475	glutathione-regulated potassium exporter activity
GKS42_RS11395	COG0515	serine threonine protein kinase
GKS42_RS11405	COG0363	glucosamine-6-phosphate deaminase activity
GKS42_RS11420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKS42_RS11430	COG0109	protoheme IX farnesyltransferase activity
GKS42_RS11485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GKS42_RS11490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKS42_RS11510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKS42_RS11525	COG1160	GTP binding
GKS42_RS11535	COG0583	DNA-binding transcription factor activity
GKS42_RS11540	COG1609	Transcriptional regulator
GKS42_RS11550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKS42_RS11605	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS11615	COG1175	transmembrane transport
GKS42_RS11620	COG0395	ABC-type sugar transport system, permease component
GKS42_RS11650	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS11655	COG0783	Belongs to the Dps family
GKS42_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS11675	COG0723	plastoquinol--plastocyanin reductase activity
GKS42_RS11680	COG1113	amino acid transport
GKS42_RS11705	COG1295	ribonuclease BN
GKS42_RS11745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKS42_RS11750	COG0693	protein deglycase activity
GKS42_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS11790	COG1472	Belongs to the glycosyl hydrolase 3 family
GKS42_RS11795	COG3876	Protein conserved in bacteria
GKS42_RS11805	COG2267	carboxylic ester hydrolase activity
GKS42_RS11810	COG1309	transcriptional regulator
GKS42_RS11815	COG0659	secondary active sulfate transmembrane transporter activity
GKS42_RS11825	COG1309	transcriptional regulator
GKS42_RS11830	COG1803	Methylglyoxal synthase
GKS42_RS11830	COG1597	lipid kinase activity
GKS42_RS11835	COG0656	L-ascorbic acid biosynthetic process
GKS42_RS11860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GKS42_RS11875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS11885	COG0402	S-adenosylhomocysteine deaminase activity
GKS42_RS11890	COG1653	transport
GKS42_RS11895	COG1175	transmembrane transport
GKS42_RS11915	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS11920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKS42_RS11925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS11930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GKS42_RS11930	COG3608	succinylglutamate desuccinylase aspartoacylase
GKS42_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS11950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKS42_RS11960	COG1053	succinate dehydrogenase
GKS42_RS11965	COG4989	oxidoreductase activity
GKS42_RS11980	COG0477	Major facilitator Superfamily
GKS42_RS11990	COG0596	Alpha beta hydrolase
GKS42_RS12005	COG1174	glycine betaine transport
GKS42_RS12010	COG1174	glycine betaine transport
GKS42_RS12015	COG1125	glycine betaine transport
GKS42_RS12040	COG0667	Aldo Keto reductase
GKS42_RS12055	COG1920	GTP binding
GKS42_RS12060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GKS42_RS12065	COG2814	Major facilitator Superfamily
GKS42_RS12090	COG2197	response regulator
GKS42_RS12095	COG4585	Histidine kinase
GKS42_RS12125	COG2217	Heavy metal translocating P-type atpase
GKS42_RS12135	COG4152	abc transporter atp-binding protein
GKS42_RS12140	COG2197	response regulator
GKS42_RS12145	COG4585	Histidine kinase
GKS42_RS12185	COG3360	Dodecin
GKS42_RS12210	COG0673	inositol 2-dehydrogenase activity
GKS42_RS12230	COG3718	enzyme involved in inositol metabolism
GKS42_RS12240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS12255	COG1175	transmembrane transport
GKS42_RS12260	COG0395	ABC-type sugar transport system, permease component
GKS42_RS12325	COG1609	Transcriptional regulator
GKS42_RS12350	COG1653	transport
GKS42_RS12355	COG0395	ABC-type sugar transport system, permease component
GKS42_RS12375	COG1176	ABC-type spermidine putrescine transport system, permease component I
GKS42_RS12385	COG3842	ATPase activity
GKS42_RS12415	COG0395	ABC-type sugar transport system, permease component
GKS42_RS12420	COG1175	transmembrane transport
GKS42_RS12455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKS42_RS12465	COG1486	melibiose metabolic process
GKS42_RS12470	COG0454	-acetyltransferase
GKS42_RS12530	COG2964	Protein conserved in bacteria
GKS42_RS12535	COG0747	negative chemotaxis
GKS42_RS12540	COG0601	transmembrane transport
GKS42_RS12545	COG1228	amidohydrolase
GKS42_RS12560	COG4608	Belongs to the ABC transporter superfamily
GKS42_RS12575	COG0395	ABC-type sugar transport system, permease component
GKS42_RS12580	COG1175	transmembrane transport
GKS42_RS12590	COG3976	FMN-binding domain protein
GKS42_RS12590	COG1053	succinate dehydrogenase
GKS42_RS12595	COG1609	Transcriptional regulator
GKS42_RS12625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS12630	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS12635	COG1120	ATPase activity
GKS42_RS12655	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GKS42_RS12655	COG0778	Nitroreductase
GKS42_RS12670	COG0640	Transcriptional regulator
GKS42_RS12685	COG2814	Major facilitator Superfamily
GKS42_RS12700	COG1595	DNA-templated transcription, initiation
GKS42_RS12735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GKS42_RS12740	COG1643	Atp-dependent helicase
GKS42_RS12775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS12790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GKS42_RS12830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GKS42_RS12840	COG1349	DNA-binding transcription factor activity
GKS42_RS12865	COG0009	L-threonylcarbamoyladenylate synthase
GKS42_RS12885	COG2318	DinB family
GKS42_RS12915	COG2226	methyltransferase
GKS42_RS12930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GKS42_RS12930	COG0456	acetyltransferase
GKS42_RS12940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS12960	COG0346	lactoylglutathione lyase activity
GKS42_RS12980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKS42_RS13000	COG2890	protein-(glutamine-N5) methyltransferase activity
GKS42_RS13015	COG0667	Aldo Keto reductase
GKS42_RS13025	COG1216	Glycosyl transferase, family 2
GKS42_RS13045	COG0805	protein transport
GKS42_RS13050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKS42_RS13065	COG2378	regulation of single-species biofilm formation
GKS42_RS13090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKS42_RS13095	COG0140	phosphoribosyl-ATP diphosphatase activity
GKS42_RS13100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GKS42_RS13105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKS42_RS13110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GKS42_RS13120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GKS42_RS13125	COG1011	Hydrolase
GKS42_RS13130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GKS42_RS13135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKS42_RS13145	COG1758	RNA polymerase activity
GKS42_RS13150	COG0194	GDP metabolic process
GKS42_RS13160	COG0284	orotidine-5'-phosphate decarboxylase activity
GKS42_RS13165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKS42_RS13175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKS42_RS13180	COG0540	Belongs to the ATCase OTCase family
GKS42_RS13185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GKS42_RS13190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKS42_RS13205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKS42_RS13210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKS42_RS13225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKS42_RS13230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKS42_RS13235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GKS42_RS13240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GKS42_RS13250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKS42_RS13260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKS42_RS13265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKS42_RS13280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKS42_RS13295	COG2409	Drug exporters of the RND superfamily
GKS42_RS13305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GKS42_RS13310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GKS42_RS13325	COG0124	histidyl-tRNA synthetase
GKS42_RS13335	COG1196	nuclear chromosome segregation
GKS42_RS13340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKS42_RS13345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GKS42_RS13350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKS42_RS13355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKS42_RS13365	COG2255	four-way junction helicase activity
GKS42_RS13370	COG0632	four-way junction helicase activity
GKS42_RS13375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GKS42_RS13380	COG0217	transcriptional regulatory protein
GKS42_RS13385	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GKS42_RS13390	COG0494	nUDIX hydrolase
GKS42_RS13395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GKS42_RS13410	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS13415	COG1560	Kdo2-lipid A biosynthetic process
GKS42_RS13420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GKS42_RS13430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKS42_RS13490	COG1140	nitrate reductase beta subunit
GKS42_RS13555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GKS42_RS13610	COG1403	HNH endonuclease
GKS42_RS13645	COG0183	Belongs to the thiolase family
GKS42_RS13650	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKS42_RS13650	COG1024	Enoyl-CoA hydratase
GKS42_RS13655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKS42_RS13660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKS42_RS13685	COG1175	transmembrane transport
GKS42_RS13690	COG0395	ABC-type sugar transport system, permease component
GKS42_RS13700	COG0318	PFAM AMP-dependent synthetase and ligase
GKS42_RS13720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GKS42_RS13735	COG0531	amino acid
GKS42_RS13745	COG0569	domain protein
GKS42_RS13770	COG0756	dUTP diphosphatase activity
GKS42_RS13790	COG1435	thymidine kinase activity
GKS42_RS13810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GKS42_RS13830	COG0187	DNA topoisomerase II activity
GKS42_RS13860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKS42_RS13860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKS42_RS13865	COG0509	glycine decarboxylation via glycine cleavage system
GKS42_RS13870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GKS42_RS13875	COG0589	response to stress
GKS42_RS13900	COG0741	lytic transglycosylase activity
GKS42_RS13905	COG0515	serine threonine protein kinase
GKS42_RS13905	COG2815	serine threonine protein kinase
GKS42_RS13910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GKS42_RS13915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GKS42_RS13920	COG0205	6-phosphofructokinase activity
GKS42_RS13935	COG1022	Amp-dependent synthetase and ligase
GKS42_RS13950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKS42_RS13955	COG2205	protein histidine kinase activity
GKS42_RS13955	COG0784	Response regulator, receiver
GKS42_RS13960	COG1845	cytochrome c oxidase, subunit III
GKS42_RS13965	COG2010	Cytochrome c
GKS42_RS13970	COG0723	plastoquinol--plastocyanin reductase activity
GKS42_RS13975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GKS42_RS13990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKS42_RS13995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKS42_RS14025	COG0667	Aldo Keto reductase
GKS42_RS14035	COG1595	DNA-templated transcription, initiation
GKS42_RS14050	COG0167	dihydroorotate dehydrogenase activity
GKS42_RS14065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKS42_RS14070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKS42_RS14075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKS42_RS14080	COG1090	epimerase
GKS42_RS14085	COG1252	NADH dehydrogenase
GKS42_RS14090	COG0515	serine threonine protein kinase
GKS42_RS14125	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14130	COG4209	transmembrane transport
GKS42_RS14135	COG1609	Transcriptional regulator
GKS42_RS14145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GKS42_RS14155	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14160	COG1175	transmembrane transport
GKS42_RS14180	COG0321	lipoyl(octanoyl) transferase activity
GKS42_RS14185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GKS42_RS14195	COG1252	NADH dehydrogenase
GKS42_RS14200	COG2264	protein methyltransferase activity
GKS42_RS14210	COG0174	glutamine synthetase
GKS42_RS14220	COG3093	addiction module antidote protein HigA
GKS42_RS14225	COG0110	maltose O-acetyltransferase activity
GKS42_RS14230	COG0583	DNA-binding transcription factor activity
GKS42_RS14235	COG0667	Aldo Keto reductase
GKS42_RS14240	COG4989	oxidoreductase activity
GKS42_RS14245	COG0667	Aldo Keto reductase
GKS42_RS14290	COG2197	response regulator
GKS42_RS14300	COG4585	Histidine kinase
GKS42_RS14315	COG2197	response regulator
GKS42_RS14320	COG4172	Belongs to the ABC transporter superfamily
GKS42_RS14335	COG0747	negative chemotaxis
GKS42_RS14345	COG1476	TRANSCRIPTIONal
GKS42_RS14350	COG1309	transcriptional regulator
GKS42_RS14360	COG0604	alcohol dehydrogenase
GKS42_RS14375	COG2267	carboxylic ester hydrolase activity
GKS42_RS14425	COG1960	acyl-CoA dehydrogenase activity
GKS42_RS14435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKS42_RS14445	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14455	COG1653	transport
GKS42_RS14460	COG4670	ketone body catabolic process
GKS42_RS14470	COG5504	Zn-dependent protease
GKS42_RS14475	COG2234	aminopeptidase activity
GKS42_RS14485	COG1175	transmembrane transport
GKS42_RS14490	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14510	COG1653	transport
GKS42_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS14525	COG1940	carbohydrate kinase activity
GKS42_RS14595	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS14600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKS42_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS14615	COG2207	Transcriptional regulator
GKS42_RS14615	COG1609	Transcriptional regulator
GKS42_RS14620	COG0673	inositol 2-dehydrogenase activity
GKS42_RS14625	COG1082	Xylose isomerase domain protein TIM barrel
GKS42_RS14635	COG1175	transmembrane transport
GKS42_RS14640	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS14655	COG0673	inositol 2-dehydrogenase activity
GKS42_RS14660	COG0667	Aldo Keto reductase
GKS42_RS14670	COG4952	isomerase
GKS42_RS14675	COG1070	Carbohydrate kinase
GKS42_RS14685	COG1609	Transcriptional regulator
GKS42_RS14690	COG3250	beta-galactosidase activity
GKS42_RS14695	COG1609	Transcriptional regulator
GKS42_RS14700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKS42_RS14725	COG0747	negative chemotaxis
GKS42_RS14730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS14735	COG0601	transmembrane transport
GKS42_RS14740	COG4172	Belongs to the ABC transporter superfamily
GKS42_RS14745	COG0444	Belongs to the ABC transporter superfamily
GKS42_RS14790	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14795	COG4209	transmembrane transport
GKS42_RS14820	COG4172	Belongs to the ABC transporter superfamily
GKS42_RS14880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GKS42_RS14885	COG0174	glutamine synthetase
GKS42_RS14895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKS42_RS14910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GKS42_RS14920	COG1846	Transcriptional regulator
GKS42_RS14920	COG1940	carbohydrate kinase activity
GKS42_RS14930	COG0395	ABC-type sugar transport system, permease component
GKS42_RS14940	COG1501	Belongs to the glycosyl hydrolase 31 family
GKS42_RS14945	COG0366	Alpha amylase catalytic
GKS42_RS14960	COG0823	Involved in the tonB-independent uptake of proteins
GKS42_RS15000	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKS42_RS15030	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GKS42_RS15035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GKS42_RS15040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GKS42_RS15075	COG1690	Belongs to the RtcB family
GKS42_RS15125	COG0765	amino acid transport
GKS42_RS15140	COG3022	response to hydroperoxide
GKS42_RS15170	COG2062	phosphohistidine phosphatase, SixA
GKS42_RS15185	COG0765	amino acid transport
GKS42_RS15190	COG0765	amino acid transport
GKS42_RS15250	COG2197	response regulator
GKS42_RS15290	COG3795	YCII-related domain
GKS42_RS15295	COG4941	Belongs to the sigma-70 factor family
GKS42_RS15305	COG2190	(PTS) system
GKS42_RS15305	COG2211	Major facilitator Superfamily
GKS42_RS15310	COG0366	Alpha amylase catalytic
GKS42_RS15320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKS42_RS15360	COG0450	alkyl hydroperoxide reductase
GKS42_RS15370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GKS42_RS15400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKS42_RS15405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKS42_RS15410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKS42_RS15430	COG1703	isobutyryl-CoA mutase activity
GKS42_RS15430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKS42_RS15430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKS42_RS15460	COG0358	DNA primase activity
GKS42_RS15470	COG0366	Alpha amylase catalytic
GKS42_RS15480	COG3833	ABC-type maltose transport systems, permease component
GKS42_RS15485	COG1175	transmembrane transport
GKS42_RS15490	COG2182	Extracellular solute-binding protein
GKS42_RS15515	COG0395	ABC-type sugar transport system, permease component
GKS42_RS15520	COG1175	transmembrane transport
GKS42_RS15525	COG2182	Extracellular solute-binding protein
GKS42_RS15540	COG0423	glycine-tRNA ligase activity
GKS42_RS15555	COG1121	(ABC) transporter
GKS42_RS15560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GKS42_RS15575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKS42_RS15580	COG1381	Involved in DNA repair and RecF pathway recombination
GKS42_RS15595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKS42_RS15600	COG1595	DNA-templated transcription, initiation
GKS42_RS15625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKS42_RS15650	COG0714	Associated with various cellular activities
GKS42_RS15685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GKS42_RS15695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GKS42_RS15730	COG0484	heat shock protein binding
GKS42_RS15735	COG1420	regulation of RNA biosynthetic process
GKS42_RS15755	COG0481	GTPase activity
GKS42_RS15765	COG1305	Transglutaminase-like
GKS42_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS15840	COG0183	Belongs to the thiolase family
GKS42_RS15850	COG0268	Binds directly to 16S ribosomal RNA
GKS42_RS15960	COG0433	COG0433 Predicted ATPase
GKS42_RS15965	COG2271	Major facilitator Superfamily
GKS42_RS15975	COG0495	leucyl-tRNA aminoacylation
GKS42_RS15980	COG1609	Transcriptional regulator
GKS42_RS15990	COG3119	arylsulfatase activity
GKS42_RS16010	COG1070	Carbohydrate kinase
GKS42_RS16015	COG0246	Mannitol dehydrogenase
GKS42_RS16020	COG1904	glucuronate isomerase
GKS42_RS16025	COG1609	Transcriptional regulator
GKS42_RS16040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GKS42_RS16045	COG1606	tRNA processing
GKS42_RS16050	COG1691	(AIR) carboxylase
GKS42_RS16055	COG1253	flavin adenine dinucleotide binding
GKS42_RS16065	COG1321	iron dependent repressor
GKS42_RS16100	COG0395	ABC-type sugar transport system, permease component
GKS42_RS16110	COG1653	transport
GKS42_RS16125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS16140	COG1609	Transcriptional regulator
GKS42_RS16160	COG1132	(ABC) transporter
GKS42_RS16165	COG1132	(ABC) transporter
GKS42_RS16170	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GKS42_RS16175	COG3739	integral membrane protein
GKS42_RS16195	COG0583	DNA-binding transcription factor activity
GKS42_RS16220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GKS42_RS16230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKS42_RS16260	COG2235	arginine
GKS42_RS16315	COG2066	Belongs to the glutaminase family
GKS42_RS16365	COG0406	alpha-ribazole phosphatase activity
GKS42_RS16370	COG0799	negative regulation of ribosome biogenesis
GKS42_RS16380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKS42_RS16385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GKS42_RS16400	COG0431	NADPH-dependent FMN reductase
GKS42_RS16425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GKS42_RS16430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GKS42_RS16435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GKS42_RS16440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GKS42_RS16445	COG3340	Belongs to the peptidase S51 family
GKS42_RS16455	COG1530	ribonuclease E activity
GKS42_RS16460	COG1271	oxidase subunit
GKS42_RS16465	COG1294	oxidase, subunit
GKS42_RS16470	COG4988	ABC transporter
GKS42_RS16475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GKS42_RS16485	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS16500	COG1609	Transcriptional regulator
GKS42_RS16505	COG0800	Aldolase
GKS42_RS16510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKS42_RS16540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKS42_RS16545	COG0571	ribonuclease III activity
GKS42_RS16560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GKS42_RS16565	COG2721	sulfolactate sulfo-lyase activity
GKS42_RS16605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GKS42_RS16610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKS42_RS16615	COG0742	ribosomal rna small subunit methyltransferase
GKS42_RS16625	COG4133	protoheme IX ABC transporter activity
GKS42_RS16630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKS42_RS16635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKS42_RS16660	COG0475	glutathione-regulated potassium exporter activity
GKS42_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS16710	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKS42_RS16740	COG4585	Histidine kinase
GKS42_RS16750	COG1131	(ABC) transporter
GKS42_RS16755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKS42_RS16770	COG1131	(ABC) transporter
GKS42_RS16780	COG0066	3-isopropylmalate dehydratase activity
GKS42_RS16785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKS42_RS16790	COG1414	Transcriptional regulator
GKS42_RS16825	COG4585	Histidine kinase
GKS42_RS16830	COG1131	(ABC) transporter
GKS42_RS16840	COG4221	oxidoreductase activity
GKS42_RS16855	COG1254	Belongs to the acylphosphatase family
GKS42_RS16865	COG2814	Major facilitator Superfamily
GKS42_RS16895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKS42_RS16905	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKS42_RS16930	COG2818	Glycosylase
GKS42_RS16955	COG1136	(ABC) transporter
GKS42_RS16955	COG0577	efflux transmembrane transporter activity
GKS42_RS16980	COG1793	dna ligase
GKS42_RS16985	COG0789	Transcriptional regulator
GKS42_RS17035	COG1316	TRANSCRIPTIONal
GKS42_RS17055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKS42_RS17060	COG0113	porphobilinogen synthase activity
GKS42_RS17070	COG0181	hydroxymethylbilane synthase activity
GKS42_RS17090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKS42_RS17105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GKS42_RS17115	COG1505	serine-type exopeptidase activity
GKS42_RS17120	COG1609	Transcriptional regulator
GKS42_RS17125	COG2182	Extracellular solute-binding protein
GKS42_RS17130	COG1175	transmembrane transport
GKS42_RS17135	COG0395	ABC-type sugar transport system, permease component
GKS42_RS17160	COG0519	Catalyzes the synthesis of GMP from XMP
GKS42_RS17160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKS42_RS17165	COG0180	Tryptophanyl-tRNA synthetase
GKS42_RS17185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GKS42_RS17210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKS42_RS17230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKS42_RS17260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKS42_RS17265	COG0473	3-isopropylmalate dehydrogenase activity
GKS42_RS17285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKS42_RS17290	COG0440	acetolactate synthase activity
GKS42_RS17300	COG2154	pterin-4-alpha-carbinolamine dehydratase
GKS42_RS17305	COG0129	dihydroxy-acid dehydratase activity
GKS42_RS17340	COG4266	Belongs to the allantoicase family
GKS42_RS17345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKS42_RS17350	COG1929	Belongs to the glycerate kinase type-1 family
GKS42_RS17355	COG3960	tartronate-semialdehyde synthase activity
GKS42_RS17360	COG2084	Dehydrogenase
GKS42_RS17365	COG3622	Belongs to the hyi family
GKS42_RS17385	COG4106	trans-aconitate 2-methyltransferase activity
GKS42_RS17415	COG1414	Transcriptional regulator
GKS42_RS17420	COG2233	PERMEase
GKS42_RS17435	COG2351	hydroxyisourate hydrolase activity
GKS42_RS17480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKS42_RS17485	COG0154	amidase activity
GKS42_RS17490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKS42_RS17505	COG2207	Transcriptional regulator
GKS42_RS17510	COG0457	Tetratricopeptide repeat
GKS42_RS17525	COG1175	transmembrane transport
GKS42_RS17570	COG0659	secondary active sulfate transmembrane transporter activity
GKS42_RS17580	COG2909	trisaccharide binding
GKS42_RS17615	COG1984	allophanate hydrolase subunit 2
GKS42_RS17625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GKS42_RS17700	COG3119	arylsulfatase activity
GKS42_RS17715	COG2207	Transcriptional regulator
GKS42_RS17715	COG3708	Transcriptional regulator
GKS42_RS17730	COG3845	ABC transporter
GKS42_RS17755	COG0673	inositol 2-dehydrogenase activity
GKS42_RS17760	COG1879	ABC-type sugar transport system periplasmic component
GKS42_RS17765	COG1172	Belongs to the binding-protein-dependent transport system permease family
GKS42_RS17775	COG1846	Transcriptional regulator
GKS42_RS17775	COG1940	carbohydrate kinase activity
GKS42_RS17790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GKS42_RS17795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKS42_RS17805	COG0471	metal ion transport
GKS42_RS17805	COG0490	domain, Protein
GKS42_RS17825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GKS42_RS17855	COG1216	Glycosyl transferase, family 2
GKS42_RS17895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GKS42_RS17910	COG2409	Drug exporters of the RND superfamily
GKS42_RS17915	COG0702	epimerase
GKS42_RS17955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKS42_RS17975	COG0482	sulfurtransferase activity
GKS42_RS18020	COG0697	spore germination
GKS42_RS18030	COG1733	regulation of RNA biosynthetic process
GKS42_RS18035	COG2084	Dehydrogenase
GKS42_RS18050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GKS42_RS18055	COG2086	electron transfer activity
GKS42_RS18070	COG0180	Tryptophanyl-tRNA synthetase
GKS42_RS18085	COG0366	Alpha amylase catalytic
GKS42_RS18095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GKS42_RS18105	COG3118	belongs to the thioredoxin family
GKS42_RS18130	COG2267	carboxylic ester hydrolase activity
GKS42_RS18160	COG1501	Belongs to the glycosyl hydrolase 31 family
GKS42_RS18175	COG1609	Transcriptional regulator
GKS42_RS18185	COG0395	ABC-type sugar transport system, permease component
GKS42_RS18190	COG4209	transmembrane transport
GKS42_RS18200	COG1472	Belongs to the glycosyl hydrolase 3 family
GKS42_RS18220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GKS42_RS18230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GKS42_RS18240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GKS42_RS18245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GKS42_RS18250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GKS42_RS18255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GKS42_RS18260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKS42_RS18265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKS42_RS18270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKS42_RS18275	COG0356	it plays a direct role in the translocation of protons across the membrane
GKS42_RS18300	COG2890	protein-(glutamine-N5) methyltransferase activity
GKS42_RS18305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKS42_RS18315	COG0083	homoserine kinase activity
GKS42_RS18320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKS42_RS18325	COG0460	homoserine dehydrogenase
GKS42_RS18330	COG0019	diaminopimelate decarboxylase activity
GKS42_RS18335	COG0018	arginyl-trna synthetase
GKS42_RS18350	COG2017	converts alpha-aldose to the beta-anomer
GKS42_RS18355	COG0741	lytic transglycosylase activity
GKS42_RS18355	COG1196	nuclear chromosome segregation
GKS42_RS18355	COG0739	heme binding
GKS42_RS18360	COG1253	flavin adenine dinucleotide binding
GKS42_RS18365	COG1253	flavin adenine dinucleotide binding
GKS42_RS18370	COG0745	RESPONSE REGULATOR receiver
GKS42_RS18375	COG2205	protein histidine kinase activity
GKS42_RS18380	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKS42_RS18380	COG0567	Dehydrogenase, E1 component
GKS42_RS18400	COG0733	neurotransmitter:sodium symporter activity
GKS42_RS18410	COG3321	synthase
GKS42_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS18410	COG0604	alcohol dehydrogenase
GKS42_RS18420	COG0673	inositol 2-dehydrogenase activity
GKS42_RS18425	COG5662	AntiSigma factor
GKS42_RS18430	COG1595	DNA-templated transcription, initiation
GKS42_RS18440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GKS42_RS18445	COG1162	GTPase activity
GKS42_RS18460	COG1053	succinate dehydrogenase
GKS42_RS18485	COG3458	cephalosporin-C deacetylase activity
GKS42_RS18490	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS18495	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS18500	COG0395	ABC-type sugar transport system, permease component
GKS42_RS18510	COG1653	transport
GKS42_RS18525	COG1414	Transcriptional regulator
GKS42_RS18530	COG0483	inositol monophosphate 1-phosphatase activity
GKS42_RS18535	COG1487	ribonuclease activity
GKS42_RS18545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GKS42_RS18565	COG0489	protein tyrosine kinase activity
GKS42_RS18580	COG3835	regulator
GKS42_RS18585	COG0590	tRNA wobble adenosine to inosine editing
GKS42_RS18590	COG2233	PERMEase
GKS42_RS18610	COG0653	protein targeting
GKS42_RS18615	COG3214	Protein conserved in bacteria
GKS42_RS18620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GKS42_RS18625	COG1040	competence protein
GKS42_RS18630	COG5401	PFAM Sporulation and spore germination
GKS42_RS18635	COG5002	protein histidine kinase activity
GKS42_RS18660	COG0714	Associated with various cellular activities
GKS42_RS18675	COG2186	Transcriptional regulator
GKS42_RS18690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GKS42_RS18695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GKS42_RS18700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GKS42_RS18705	COG2385	sporulation resulting in formation of a cellular spore
GKS42_RS18715	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GKS42_RS18735	COG0463	Glycosyl transferase, family 2
GKS42_RS18770	COG3754	Rhamnan synthesis protein F
GKS42_RS18825	COG2835	tetraacyldisaccharide 4'-kinase activity
GKS42_RS18870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKS42_RS18880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GKS42_RS18905	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS18910	COG1132	(ABC) transporter
GKS42_RS18950	COG1316	TRANSCRIPTIONal
GKS42_RS18955	COG1316	TRANSCRIPTIONal
GKS42_RS18960	COG1316	TRANSCRIPTIONal
GKS42_RS18965	COG1832	CoA-binding protein
GKS42_RS18980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GKS42_RS18995	COG2205	protein histidine kinase activity
GKS42_RS19000	COG0745	RESPONSE REGULATOR receiver
GKS42_RS19020	COG2323	membrane
GKS42_RS19025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKS42_RS19090	COG0424	maF-like protein
GKS42_RS19095	COG4770	biotin carboxylase activity
GKS42_RS19105	COG2171	N-acyltransferase activity
GKS42_RS19175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS19190	COG2838	Isocitrate dehydrogenase
GKS42_RS19215	COG2318	DinB family
GKS42_RS19220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKS42_RS19235	COG2814	Major facilitator Superfamily
GKS42_RS19245	COG0673	inositol 2-dehydrogenase activity
GKS42_RS19280	COG0596	Alpha beta hydrolase
GKS42_RS19285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GKS42_RS19295	COG1309	transcriptional regulator
GKS42_RS19310	COG2197	response regulator
GKS42_RS19315	COG4585	Histidine kinase
GKS42_RS19320	COG2207	Transcriptional regulator
GKS42_RS19320	COG3708	Transcriptional regulator
GKS42_RS19355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKS42_RS19395	COG0012	GTP binding
GKS42_RS19410	COG1322	Protein conserved in bacteria
GKS42_RS19425	COG1653	transport
GKS42_RS19430	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS19435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKS42_RS19440	COG2390	Transcriptional regulator
GKS42_RS19450	COG1570	exodeoxyribonuclease VII activity
GKS42_RS19455	COG1722	exodeoxyribonuclease VII activity
GKS42_RS19490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKS42_RS19495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GKS42_RS19500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKS42_RS19510	COG2326	polyphosphate kinase activity
GKS42_RS19525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKS42_RS19545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKS42_RS19550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GKS42_RS19560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKS42_RS19575	COG3458	cephalosporin-C deacetylase activity
GKS42_RS19585	COG1131	(ABC) transporter
GKS42_RS19595	COG4585	Histidine kinase
GKS42_RS19600	COG2197	response regulator
GKS42_RS19640	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKS42_RS19645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKS42_RS19650	COG0346	lactoylglutathione lyase activity
GKS42_RS19655	COG1802	Transcriptional regulator
GKS42_RS19705	COG1902	pentaerythritol trinitrate reductase activity
GKS42_RS19750	COG0148	phosphopyruvate hydratase activity
GKS42_RS19765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GKS42_RS19785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GKS42_RS19790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GKS42_RS19800	COG1104	cysteine desulfurase activity
GKS42_RS19805	COG4691	Plasmid stability protein
GKS42_RS19810	COG1487	ribonuclease activity
GKS42_RS19825	COG1316	TRANSCRIPTIONal
GKS42_RS19835	COG0193	aminoacyl-tRNA hydrolase activity
GKS42_RS19840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GKS42_RS19855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GKS42_RS19865	COG1309	transcriptional regulator
GKS42_RS19870	COG4152	abc transporter atp-binding protein
GKS42_RS19875	COG1668	transmembrane transport
GKS42_RS19880	COG1846	Transcriptional regulator
GKS42_RS19885	COG0488	(ABC) transporter
GKS42_RS19900	COG2409	Drug exporters of the RND superfamily
GKS42_RS19905	COG1309	transcriptional regulator
GKS42_RS19910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GKS42_RS19915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKS42_RS19930	COG0084	hydrolase, TatD family'
GKS42_RS19935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKS42_RS19945	COG4412	M6 family metalloprotease domain protein
GKS42_RS19945	COG1404	Belongs to the peptidase S8 family
GKS42_RS19950	COG2133	pyrroloquinoline quinone binding
GKS42_RS19970	COG0302	gtp cyclohydrolase
GKS42_RS19985	COG0436	Aminotransferase
GKS42_RS19990	COG1335	isochorismatase
GKS42_RS19995	COG0454	-acetyltransferase
GKS42_RS19995	COG0456	acetyltransferase
GKS42_RS20020	COG0395	ABC-type sugar transport system, permease component
GKS42_RS20025	COG1175	transmembrane transport
GKS42_RS20035	COG3408	Glycogen debranching enzyme
GKS42_RS20045	COG0656	L-ascorbic acid biosynthetic process
GKS42_RS20060	COG0596	Alpha beta hydrolase
GKS42_RS20075	COG1609	Transcriptional regulator
GKS42_RS20080	COG0435	Glutathione S-transferase
GKS42_RS20090	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
GKS42_RS20100	COG0488	(ABC) transporter
GKS42_RS20125	COG0110	maltose O-acetyltransferase activity
GKS42_RS20145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GKS42_RS20155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GKS42_RS20160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKS42_RS20165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GKS42_RS20175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKS42_RS20215	COG2244	polysaccharide biosynthetic process
GKS42_RS20240	COG0463	Glycosyl transferase, family 2
GKS42_RS20275	COG2376	Dihydroxyacetone kinase
GKS42_RS20300	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKS42_RS20320	COG0579	oxidoreductase
GKS42_RS20335	COG1124	(ABC) transporter
GKS42_RS20360	COG0583	DNA-binding transcription factor activity
GKS42_RS20365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKS42_RS20370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKS42_RS20370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKS42_RS20425	COG3173	Aminoglycoside phosphotransferase
GKS42_RS20460	COG2205	protein histidine kinase activity
GKS42_RS20465	COG0745	RESPONSE REGULATOR receiver
GKS42_RS20480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKS42_RS20505	COG0789	Transcriptional regulator
GKS42_RS20520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKS42_RS20530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKS42_RS20550	COG1970	mechanosensitive ion channel activity
GKS42_RS20560	COG3189	MarR family transcriptional regulator
GKS42_RS20565	COG2197	response regulator
GKS42_RS20570	COG4585	Histidine kinase
GKS42_RS20580	COG1131	(ABC) transporter
GKS42_RS20615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKS42_RS20640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GKS42_RS20645	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS20655	COG1122	ATPase activity
GKS42_RS20660	COG4721	ABC-type cobalt transport system, permease component
GKS42_RS20670	COG2814	Major facilitator Superfamily
GKS42_RS20685	COG2252	PERMEase
GKS42_RS20695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKS42_RS20710	COG4106	trans-aconitate 2-methyltransferase activity
GKS42_RS20770	COG2271	Major facilitator Superfamily
GKS42_RS20775	COG1086	Polysaccharide biosynthesis protein
GKS42_RS20790	COG1278	Cold shock
GKS42_RS20795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKS42_RS20800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKS42_RS20820	COG0438	transferase activity, transferring glycosyl groups
GKS42_RS20840	COG0489	protein tyrosine kinase activity
GKS42_RS20845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKS42_RS20860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GKS42_RS20870	COG0667	Aldo Keto reductase
GKS42_RS20915	COG3340	Belongs to the peptidase S51 family
GKS42_RS20945	COG1842	Phage shock protein A
GKS42_RS20960	COG0745	RESPONSE REGULATOR receiver
GKS42_RS20965	COG2205	protein histidine kinase activity
GKS42_RS20985	COG3585	molybdate ion transport
GKS42_RS21005	COG0315	cyclic pyranopterin monophosphate synthase activity
GKS42_RS21045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKS42_RS21055	COG0315	cyclic pyranopterin monophosphate synthase activity
GKS42_RS21055	COG0521	Mo-molybdopterin cofactor biosynthetic process
GKS42_RS21080	COG0459	protein refolding
GKS42_RS21105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GKS42_RS21130	COG4946	Tricorn protease homolog
GKS42_RS21130	COG1506	peptidase
GKS42_RS21130	COG0823	Involved in the tonB-independent uptake of proteins
GKS42_RS21165	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GKS42_RS21175	COG3842	ATPase activity
GKS42_RS21190	COG0395	ABC-type sugar transport system, permease component
GKS42_RS21195	COG1175	transmembrane transport
GKS42_RS21205	COG1609	Transcriptional regulator
GKS42_RS21215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKS42_RS21220	COG0215	cysteine-tRNA ligase activity
GKS42_RS21225	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKS42_RS21235	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS21245	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS21250	COG3386	PFAM SMP-30 Gluconolaconase
GKS42_RS21255	COG0395	ABC-type sugar transport system, permease component
GKS42_RS21260	COG1175	transmembrane transport
GKS42_RS21270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKS42_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS21300	COG1132	(ABC) transporter
GKS42_RS21320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKS42_RS21325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKS42_RS21330	COG1329	Transcriptional regulator
GKS42_RS21345	COG5002	protein histidine kinase activity
GKS42_RS21355	COG0588	phosphoglycerate mutase activity
GKS42_RS21370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GKS42_RS21375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKS42_RS21395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GKS42_RS21405	COG0302	gtp cyclohydrolase
GKS42_RS21410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKS42_RS21420	COG0037	tRNA processing
GKS42_RS21430	COG2027	D-alanyl-D-alanine carboxypeptidase
GKS42_RS21435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKS42_RS21455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKS42_RS21475	COG0247	lactate metabolic process
GKS42_RS21475	COG0277	FAD linked oxidase domain protein
GKS42_RS21495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKS42_RS21505	COG0531	amino acid
GKS42_RS21510	COG0477	Major facilitator Superfamily
GKS42_RS21540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GKS42_RS21570	COG0596	Alpha beta hydrolase
GKS42_RS21610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GKS42_RS21615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GKS42_RS21630	COG0673	inositol 2-dehydrogenase activity
GKS42_RS21635	COG1754	DNA topoisomerase type I activity
GKS42_RS21635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKS42_RS21640	COG0714	Associated with various cellular activities
GKS42_RS21675	COG2890	protein-(glutamine-N5) methyltransferase activity
GKS42_RS21690	COG0300	oxidoreductase activity
GKS42_RS21695	COG0662	Cupin 2, conserved barrel domain protein
GKS42_RS21700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKS42_RS21725	COG1595	DNA-templated transcription, initiation
GKS42_RS21740	COG4209	transmembrane transport
GKS42_RS21745	COG0395	ABC-type sugar transport system, permease component
GKS42_RS21750	COG1309	transcriptional regulator
GKS42_RS21770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKS42_RS21785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GKS42_RS21795	COG1309	transcriptional regulator
GKS42_RS21850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKS42_RS21855	COG0596	Alpha beta hydrolase
GKS42_RS21885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GKS42_RS21900	COG2233	PERMEase
GKS42_RS21905	COG1051	belongs to the nudix hydrolase family
GKS42_RS21910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GKS42_RS21930	COG0444	Belongs to the ABC transporter superfamily
GKS42_RS21935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS21940	COG0601	transmembrane transport
GKS42_RS21945	COG4166	transmembrane transport
GKS42_RS21960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GKS42_RS22000	COG1131	(ABC) transporter
GKS42_RS22015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GKS42_RS22030	COG1253	flavin adenine dinucleotide binding
GKS42_RS22065	COG1122	ATPase activity
GKS42_RS22085	COG1063	alcohol dehydrogenase
GKS42_RS22115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKS42_RS22175	COG1192	Involved in chromosome partitioning
GKS42_RS22230	COG1136	(ABC) transporter
GKS42_RS22260	COG1175	transmembrane transport
GKS42_RS22265	COG0395	ABC-type sugar transport system, permease component
GKS42_RS22275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKS42_RS22330	COG0583	DNA-binding transcription factor activity
GKS42_RS22345	COG1070	Carbohydrate kinase
GKS42_RS22350	COG3347	Dehydrogenase
GKS42_RS22350	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS22355	COG4952	isomerase
GKS42_RS22365	COG0129	dihydroxy-acid dehydratase activity
GKS42_RS22370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKS42_RS22375	COG0318	PFAM AMP-dependent synthetase and ligase
GKS42_RS22380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKS42_RS22385	COG1063	alcohol dehydrogenase
GKS42_RS22410	COG1737	Transcriptional regulator
GKS42_RS22415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GKS42_RS22420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GKS42_RS22430	COG4608	Belongs to the ABC transporter superfamily
GKS42_RS22440	COG0601	transmembrane transport
GKS42_RS22460	COG3876	Protein conserved in bacteria
GKS42_RS22480	COG0395	ABC-type sugar transport system, permease component
GKS42_RS22485	COG4209	transmembrane transport
GKS42_RS22490	COG1653	transport
GKS42_RS22530	COG3534	alpha-L-arabinofuranosidase
GKS42_RS22540	COG1063	alcohol dehydrogenase
GKS42_RS22545	COG2160	L-arabinose isomerase activity
GKS42_RS22560	COG1609	Transcriptional regulator
GKS42_RS22565	COG5578	integral membrane protein
GKS42_RS22570	COG1653	transport
GKS42_RS22575	COG4209	transmembrane transport
GKS42_RS22580	COG0395	ABC-type sugar transport system, permease component
GKS42_RS22585	COG2755	lipolytic protein G-D-S-L family
GKS42_RS22615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GKS42_RS22615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GKS42_RS22625	COG1063	alcohol dehydrogenase
GKS42_RS22630	COG0513	Belongs to the DEAD box helicase family
GKS42_RS22645	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS22675	COG1490	D-aminoacyl-tRNA deacylase activity
GKS42_RS22700	COG3485	protocatechuate 3,4-dioxygenase
GKS42_RS22710	COG0745	RESPONSE REGULATOR receiver
GKS42_RS22720	COG0306	phosphate transporter
GKS42_RS22735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GKS42_RS22760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GKS42_RS22765	COG0456	acetyltransferase
GKS42_RS22785	COG1305	Transglutaminase-like
GKS42_RS22805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GKS42_RS22820	COG1472	Belongs to the glycosyl hydrolase 3 family
GKS42_RS22865	COG0363	glucosamine-6-phosphate deaminase activity
GKS42_RS22870	COG2261	transglycosylase associated protein
GKS42_RS22885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKS42_RS22895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GKS42_RS22925	COG0577	efflux transmembrane transporter activity
GKS42_RS22925	COG1136	(ABC) transporter
GKS42_RS22950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GKS42_RS22960	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GKS42_RS22975	COG1525	nuclease
GKS42_RS22975	COG0737	Belongs to the 5'-nucleotidase family
GKS42_RS22975	COG4085	toxin activity
GKS42_RS22980	COG1162	GTPase activity
GKS42_RS22990	COG1609	Transcriptional regulator
GKS42_RS23000	COG4209	transmembrane transport
GKS42_RS23005	COG0395	ABC-type sugar transport system, permease component
GKS42_RS23025	COG0598	Magnesium transport protein CorA
GKS42_RS23030	COG0477	Major facilitator Superfamily
GKS42_RS23040	COG0024	Methionine aminopeptidase
GKS42_RS23055	COG0596	Alpha beta hydrolase
GKS42_RS23065	COG3142	Participates in the control of copper homeostasis
GKS42_RS23070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GKS42_RS23090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23100	COG4166	transmembrane transport
GKS42_RS23105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23110	COG0747	negative chemotaxis
GKS42_RS23125	COG0601	transmembrane transport
GKS42_RS23130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKS42_RS23140	COG0668	transmembrane transport
GKS42_RS23145	COG0840	transmembrane signaling receptor activity
GKS42_RS23160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23180	COG1473	amidohydrolase
GKS42_RS23195	COG2409	Drug exporters of the RND superfamily
GKS42_RS23220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKS42_RS23230	COG0647	UMP catabolic process
GKS42_RS23250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKS42_RS23255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKS42_RS23280	COG0747	negative chemotaxis
GKS42_RS23285	COG0601	transmembrane transport
GKS42_RS23300	COG4608	Belongs to the ABC transporter superfamily
GKS42_RS23310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKS42_RS23315	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS23345	COG0436	Aminotransferase
GKS42_RS23400	COG0667	Aldo Keto reductase
GKS42_RS23405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKS42_RS23430	COG0183	Belongs to the thiolase family
GKS42_RS23435	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS23440	COG2030	dehydratase
GKS42_RS23450	COG1653	transport
GKS42_RS23455	COG1175	transmembrane transport
GKS42_RS23460	COG0395	ABC-type sugar transport system, permease component
GKS42_RS23480	COG4209	transmembrane transport
GKS42_RS23485	COG0395	ABC-type sugar transport system, permease component
GKS42_RS23520	COG0628	permease
GKS42_RS23525	COG2119	membrane
GKS42_RS23530	COG0328	RNA-DNA hybrid ribonuclease activity
GKS42_RS23535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GKS42_RS23540	COG0543	2 iron, 2 sulfur cluster binding
GKS42_RS23540	COG0633	Ferredoxin
GKS42_RS23555	COG0047	phosphoribosylformylglycinamidine synthase activity
GKS42_RS23560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKS42_RS23570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GKS42_RS23605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKS42_RS23625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKS42_RS23640	COG0737	Belongs to the 5'-nucleotidase family
GKS42_RS23645	COG0151	Belongs to the GarS family
GKS42_RS23670	COG2272	Belongs to the type-B carboxylesterase lipase family
GKS42_RS23675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKS42_RS23715	COG1704	LemA family
GKS42_RS23720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKS42_RS23725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GKS42_RS23745	COG0542	response to heat
GKS42_RS23820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GKS42_RS23825	COG0829	nickel cation binding
GKS42_RS23840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKS42_RS23865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKS42_RS23880	COG2268	Band 7 protein
GKS42_RS23890	COG0154	amidase activity
GKS42_RS23905	COG1063	alcohol dehydrogenase
GKS42_RS23915	COG4941	Belongs to the sigma-70 factor family
GKS42_RS23925	COG5285	phytanoyl-CoA dioxygenase
GKS42_RS23945	COG1505	serine-type exopeptidase activity
GKS42_RS23965	COG2315	Protein conserved in bacteria
GKS42_RS24015	COG2723	6-phospho-beta-galactosidase activity
GKS42_RS24020	COG4172	Belongs to the ABC transporter superfamily
GKS42_RS24025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS24030	COG0601	transmembrane transport
GKS42_RS24050	COG0789	Transcriptional regulator
GKS42_RS24055	COG0484	heat shock protein binding
GKS42_RS24065	COG0443	Heat shock 70 kDa protein
GKS42_RS24070	COG1131	(ABC) transporter
GKS42_RS24080	COG3851	Histidine kinase
GKS42_RS24085	COG2197	response regulator
GKS42_RS24165	COG3795	YCII-related domain
GKS42_RS24180	COG1595	DNA-templated transcription, initiation
GKS42_RS24185	COG1090	epimerase
GKS42_RS24225	COG1136	(ABC) transporter
GKS42_RS24225	COG0577	efflux transmembrane transporter activity
GKS42_RS24230	COG0577	efflux transmembrane transporter activity
GKS42_RS24240	COG2197	response regulator
GKS42_RS24260	COG2514	catechol 2,3-dioxygenase activity
GKS42_RS24265	COG3842	ATPase activity
GKS42_RS24290	COG2212	antiporter activity
GKS42_RS24305	COG1006	Multisubunit Na H antiporter MnhC subunit
GKS42_RS24310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKS42_RS24310	COG2111	Na H antiporter
GKS42_RS24320	COG0717	Belongs to the dCTP deaminase family
GKS42_RS24330	COG0667	Aldo Keto reductase
GKS42_RS24340	COG0616	signal peptide processing
GKS42_RS24345	COG0166	Belongs to the GPI family
GKS42_RS24420	COG3795	YCII-related domain
GKS42_RS24485	COG1309	transcriptional regulator
GKS42_RS24525	COG4941	Belongs to the sigma-70 factor family
GKS42_RS24545	COG0583	DNA-binding transcription factor activity
GKS42_RS24555	COG4948	Mandelate Racemase Muconate Lactonizing
GKS42_RS24565	COG4209	transmembrane transport
GKS42_RS24570	COG0395	ABC-type sugar transport system, permease component
GKS42_RS24580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKS42_RS24615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKS42_RS24620	COG0601	transmembrane transport
GKS42_RS24625	COG4166	transmembrane transport
GKS42_RS24645	COG0823	Involved in the tonB-independent uptake of proteins
GKS42_RS24645	COG1506	peptidase
GKS42_RS24665	COG0714	Associated with various cellular activities
GKS42_RS24695	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKS42_RS24700	COG0022	dehydrogenase e1 component
GKS42_RS24710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKS42_RS24715	COG1950	PFAM Membrane protein of
GKS42_RS24740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKS42_RS24760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GKS42_RS24770	COG0477	Major facilitator Superfamily
GKS42_RS24775	COG0248	Ppx GppA phosphatase
GKS42_RS24785	COG1937	Protein conserved in bacteria
GKS42_RS24805	COG1028	Short-chain dehydrogenase reductase Sdr
GKS42_RS24825	COG1131	(ABC) transporter
GKS42_RS24875	COG0753	catalase activity
GKS42_RS24890	COG2169	Transcriptional regulator
GKS42_RS24890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKS42_RS24915	COG1120	ATPase activity
GKS42_RS24920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKS42_RS24925	COG4558	Periplasmic binding protein
GKS42_RS24940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKS42_RS24970	COG1074	ATP-dependent DNA helicase activity
GKS42_RS24975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GKS42_RS24985	COG2372	response to copper ion
GKS42_RS25005	COG0673	inositol 2-dehydrogenase activity
GKS42_RS25040	COG2197	response regulator
GKS42_RS25055	COG1902	pentaerythritol trinitrate reductase activity
GKS42_RS25065	COG2072	flavoprotein involved in K transport
GKS42_RS25080	COG1846	Transcriptional regulator
GKS42_RS25090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKS42_RS25105	COG0702	epimerase
GKS42_RS25145	COG1131	(ABC) transporter
GKS42_RS25150	COG1309	transcriptional regulator
GKS42_RS25160	COG4585	Histidine kinase
GKS42_RS25165	COG2197	response regulator
GKS42_RS25180	COG2197	response regulator
GKS42_RS25185	COG4585	Histidine kinase
GKS42_RS25195	COG2132	Multicopper oxidase
GKS42_RS25210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKS42_RS25245	COG1131	(ABC) transporter
GKS42_RS25255	COG4585	Histidine kinase
GKS42_RS25260	COG2197	response regulator
GKS42_RS25270	COG0702	epimerase
GKS42_RS25275	COG1733	regulation of RNA biosynthetic process
GKS42_RS25305	COG1280	lysine exporter protein (LysE YggA)
GKS42_RS25345	COG1175	transmembrane transport
GKS42_RS25350	COG0395	ABC-type sugar transport system, permease component
GKS42_RS25370	COG2826	transposase and inactivated derivatives, IS30 family
GKS42_RS25390	COG2814	Major facilitator Superfamily
GKS42_RS25400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GKS42_RS25420	COG3119	arylsulfatase activity
GKS42_RS25460	COG0187	DNA topoisomerase II activity
GKS42_RS25510	COG4209	transmembrane transport
GKS42_RS25515	COG0395	ABC-type sugar transport system, permease component
GKS42_RS25540	COG4221	oxidoreductase activity
GKS42_RS25560	COG1694	Mazg nucleotide pyrophosphohydrolase
GKS42_RS25575	COG2318	DinB family
GKS42_RS25590	COG1372	Participates in initiation and elongation during chromosome replication
GKS42_RS25590	COG0305	Participates in initiation and elongation during chromosome replication
GKS42_RS25595	COG0534	Mate efflux family protein
GKS42_RS25670	COG1222	aaa ATPase
GKS42_RS25685	COG2197	response regulator
GKS42_RS25700	COG0359	binds to the 23S rRNA
GKS42_RS25705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GKS42_RS25715	COG0360	Binds together with S18 to 16S ribosomal RNA
GKS42_RS25720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKS42_RS25730	COG1260	myo-inositol-1-phosphate synthase
GKS42_RS25735	COG1063	alcohol dehydrogenase
GKS42_RS25750	COG4941	Belongs to the sigma-70 factor family
GKS42_RS25760	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS25765	COG0584	glycerophosphoryl diester phosphodiesterase
GKS42_RS25770	COG1653	transport
GKS42_RS25775	COG0395	ABC-type sugar transport system, permease component
GKS42_RS25780	COG1175	transmembrane transport
GKS42_RS25800	COG0617	tRNA 3'-terminal CCA addition
GKS42_RS25825	COG3118	belongs to the thioredoxin family
GKS42_RS25830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKS42_RS25835	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKS42_RS25845	COG1192	Involved in chromosome partitioning
GKS42_RS25850	COG0357	Ribosomal RNA small subunit methyltransferase G
GKS42_RS25860	COG0706	membrane insertase activity
GKS42_RS25865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GKS42_RS25870	COG0594	ribonuclease P activity
GKS42_RS25875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKS42_RS25890	COG0640	Transcriptional regulator
GKS42_RS25965	COG0802	atpase or kinase