locus-tag	class	description
HAH_RS00025	COG2873	o-acetylhomoserine
HAH_RS00030	COG0560	Phosphoserine phosphatase
HAH_RS00065	COG2309	aminopeptidase activity
HAH_RS00140	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS00165	COG0346	lactoylglutathione lyase activity
HAH_RS00220	COG0471	metal ion transport
HAH_RS00220	COG3273	potassium ion transport
HAH_RS00235	COG1744	ABC transporter substrate-binding protein PnrA-like
HAH_RS00240	COG0305	Participates in initiation and elongation during chromosome replication
HAH_RS00240	COG1372	Participates in initiation and elongation during chromosome replication
HAH_RS00300	COG0534	Mate efflux family protein
HAH_RS00310	COG1522	sequence-specific DNA binding
HAH_RS00325	COG1295	ribonuclease BN
HAH_RS00330	COG0534	Mate efflux family protein
HAH_RS00340	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HAH_RS00345	COG2205	protein histidine kinase activity
HAH_RS00360	COG0300	oxidoreductase activity
HAH_RS00365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HAH_RS00380	COG0251	oxidation-reduction process
HAH_RS00395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAH_RS00425	COG0275	rRNA processing
HAH_RS00430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HAH_RS00440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAH_RS00460	COG0183	Belongs to the thiolase family
HAH_RS00475	COG0464	growth
HAH_RS00505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAH_RS00515	COG1185	polyribonucleotide nucleotidyltransferase activity
HAH_RS00530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HAH_RS00530	COG0116	Belongs to the methyltransferase superfamily
HAH_RS00545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HAH_RS00555	COG0402	S-adenosylhomocysteine deaminase activity
HAH_RS00565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HAH_RS00625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HAH_RS00645	COG0805	protein transport
HAH_RS00650	COG0406	alpha-ribazole phosphatase activity
HAH_RS00655	COG1606	tRNA processing
HAH_RS00660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAH_RS00675	COG0251	oxidation-reduction process
HAH_RS00710	COG1902	pentaerythritol trinitrate reductase activity
HAH_RS00720	COG2030	dehydratase
HAH_RS00740	COG3243	poly(R)-hydroxyalkanoic acid synthase
HAH_RS00755	COG0459	protein refolding
HAH_RS00775	COG0702	epimerase
HAH_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAH_RS00810	COG1278	Cold shock
HAH_RS00820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HAH_RS00830	COG1088	dTDP-glucose 4,6-dehydratase activity
HAH_RS00835	COG0501	Belongs to the peptidase M48B family
HAH_RS00850	COG0667	Aldo Keto reductase
HAH_RS00885	COG0613	PHP domain protein
HAH_RS00895	COG0519	Catalyzes the synthesis of GMP from XMP
HAH_RS00895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HAH_RS00905	COG0656	L-ascorbic acid biosynthetic process
HAH_RS00945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAH_RS00955	COG0459	protein refolding
HAH_RS00980	COG2205	protein histidine kinase activity
HAH_RS00985	COG0495	leucyl-tRNA aminoacylation
HAH_RS00990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HAH_RS01030	COG0022	dehydrogenase e1 component
HAH_RS01040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HAH_RS01060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HAH_RS01095	COG0167	dihydroorotate dehydrogenase activity
HAH_RS01215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HAH_RS01225	COG0556	nucleotide-excision repair
HAH_RS01255	COG1648	precorrin-2 dehydrogenase activity
HAH_RS01255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HAH_RS01335	COG0490	domain, Protein
HAH_RS01340	COG0475	glutathione-regulated potassium exporter activity
HAH_RS01370	COG0737	Belongs to the 5'-nucleotidase family
HAH_RS01385	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS01395	COG0673	inositol 2-dehydrogenase activity
HAH_RS01400	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS01420	COG0322	excinuclease ABC activity
HAH_RS01455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HAH_RS01520	COG1378	Sugar-specific transcriptional regulator TrmB
HAH_RS01525	COG0714	Associated with various cellular activities
HAH_RS01530	COG2873	o-acetylhomoserine
HAH_RS01535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HAH_RS01550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HAH_RS01555	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS01565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HAH_RS01575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HAH_RS01590	COG0731	radical SAM domain protein
HAH_RS01630	COG0181	hydroxymethylbilane synthase activity
HAH_RS01635	COG1648	precorrin-2 dehydrogenase activity
HAH_RS01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HAH_RS01680	COG0616	signal peptide processing
HAH_RS01685	COG3253	May function as heme-dependent peroxidase
HAH_RS01690	COG4106	trans-aconitate 2-methyltransferase activity
HAH_RS01695	COG0822	iron-sulfur transferase activity
HAH_RS01710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HAH_RS01720	COG0673	inositol 2-dehydrogenase activity
HAH_RS01725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HAH_RS01730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAH_RS01770	COG0438	transferase activity, transferring glycosyl groups
HAH_RS01855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HAH_RS01890	COG3118	belongs to the thioredoxin family
HAH_RS01945	COG0517	IMP dehydrogenase activity
HAH_RS01975	COG0237	dephospho-CoA kinase activity
HAH_RS01980	COG0142	geranyltranstransferase activity
HAH_RS02015	COG1269	ATP hydrolysis coupled proton transport
HAH_RS02040	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HAH_RS02045	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HAH_RS02055	COG1394	ATPase activity, coupled to movement of substances
HAH_RS02070	COG1192	Involved in chromosome partitioning
HAH_RS02085	COG0018	arginyl-trna synthetase
HAH_RS02095	COG0589	response to stress
HAH_RS02105	COG0528	UMP kinase activity
HAH_RS02120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HAH_RS02150	COG0124	histidyl-tRNA synthetase
HAH_RS02170	COG0101	tRNA pseudouridine synthase activity
HAH_RS02175	COG1164	Oligoendopeptidase f
HAH_RS02180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS02185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HAH_RS02205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HAH_RS02235	COG0166	Belongs to the GPI family
HAH_RS02265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HAH_RS02275	COG0668	transmembrane transport
HAH_RS02280	COG1968	undecaprenyl-diphosphatase activity
HAH_RS02305	COG0589	response to stress
HAH_RS02310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HAH_RS02320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS02330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS02345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HAH_RS02360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HAH_RS02380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAH_RS02475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HAH_RS02480	COG0047	phosphoribosylformylglycinamidine synthase activity
HAH_RS02495	COG0788	formyltetrahydrofolate deformylase activity
HAH_RS02500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HAH_RS02510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HAH_RS02515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HAH_RS02530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HAH_RS02535	COG0702	epimerase
HAH_RS02540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HAH_RS02585	COG4608	Belongs to the ABC transporter superfamily
HAH_RS02590	COG0444	Belongs to the ABC transporter superfamily
HAH_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAH_RS02600	COG0601	transmembrane transport
HAH_RS02605	COG4166	transmembrane transport
HAH_RS02610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HAH_RS02625	COG0596	Alpha beta hydrolase
HAH_RS02630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HAH_RS02640	COG0745	RESPONSE REGULATOR receiver
HAH_RS02670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HAH_RS02670	COG2124	cytochrome p450
HAH_RS02695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HAH_RS02730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HAH_RS02780	COG0484	heat shock protein binding
HAH_RS02805	COG0443	Heat shock 70 kDa protein
HAH_RS02810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HAH_RS02825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HAH_RS02830	COG1102	Psort location Cytoplasmic, score
HAH_RS02840	COG0563	adenylate kinase activity
HAH_RS02850	COG0083	homoserine kinase activity
HAH_RS02870	COG0446	pyridine nucleotide-disulphide oxidoreductase
HAH_RS02905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HAH_RS02910	COG5002	protein histidine kinase activity
HAH_RS02930	COG0668	transmembrane transport
HAH_RS02940	COG3290	protein histidine kinase activity
HAH_RS02945	COG1205	dead DEAH box helicase
HAH_RS02945	COG1111	helicase
HAH_RS02950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HAH_RS02955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAH_RS02960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HAH_RS02970	COG5002	protein histidine kinase activity
HAH_RS02975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HAH_RS03010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HAH_RS03015	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HAH_RS03070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HAH_RS03095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HAH_RS03100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HAH_RS03105	COG1228	amidohydrolase
HAH_RS03150	COG1446	asparaginase
HAH_RS03155	COG0024	Methionine aminopeptidase
HAH_RS03175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HAH_RS03185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HAH_RS03225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HAH_RS03255	COG0252	asparaginase activity
HAH_RS03270	COG1757	Na H antiporter
HAH_RS03285	COG4347	Protein of unknown function (DUF1405)
HAH_RS03310	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS03330	COG0589	response to stress
HAH_RS03340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HAH_RS03350	COG1597	lipid kinase activity
HAH_RS03355	COG0471	metal ion transport
HAH_RS03355	COG3273	potassium ion transport
HAH_RS03375	COG0504	CTP synthase activity
HAH_RS03380	COG0519	Catalyzes the synthesis of GMP from XMP
HAH_RS03380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HAH_RS03400	COG0656	L-ascorbic acid biosynthetic process
HAH_RS03410	COG0521	Mo-molybdopterin cofactor biosynthetic process
HAH_RS03450	COG0535	radical SAM domain protein
HAH_RS03480	COG0436	Aminotransferase
HAH_RS03490	COG0183	Belongs to the thiolase family
HAH_RS03510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HAH_RS03515	COG3321	synthase
HAH_RS03515	COG0604	alcohol dehydrogenase
HAH_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS03530	COG0484	heat shock protein binding
HAH_RS03595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HAH_RS03615	COG0651	ATP synthesis coupled electron transport
HAH_RS03620	COG0651	ATP synthesis coupled electron transport
HAH_RS03625	COG0651	ATP synthesis coupled electron transport
HAH_RS03630	COG1006	Multisubunit Na H antiporter MnhC subunit
HAH_RS03635	COG2111	Na H antiporter
HAH_RS03645	COG1320	monovalent cation:proton antiporter activity
HAH_RS03660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HAH_RS03685	COG0501	Belongs to the peptidase M48B family
HAH_RS03695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS03705	COG1078	dGTPase activity
HAH_RS03710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HAH_RS03720	COG0589	response to stress
HAH_RS03725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HAH_RS03725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HAH_RS03730	COG0439	Biotin carboxylase
HAH_RS03740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HAH_RS03765	COG0733	neurotransmitter:sodium symporter activity
HAH_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS03780	COG1064	alcohol dehydrogenase
HAH_RS03785	COG0840	transmembrane signaling receptor activity
HAH_RS03785	COG2203	Gaf domain
HAH_RS03810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HAH_RS03830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAH_RS03845	COG0456	acetyltransferase
HAH_RS03850	COG0114	fumarate hydratase activity
HAH_RS03855	COG1175	transmembrane transport
HAH_RS03860	COG0395	ABC-type sugar transport system, permease component
HAH_RS03865	COG3842	ATPase activity
HAH_RS03915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HAH_RS03920	COG0109	protoheme IX farnesyltransferase activity
HAH_RS03920	COG1612	heme a metabolic process
HAH_RS03950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HAH_RS03975	COG0489	protein tyrosine kinase activity
HAH_RS03990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HAH_RS04000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HAH_RS04020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HAH_RS04025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HAH_RS04040	COG0148	phosphopyruvate hydratase activity
HAH_RS04045	COG0052	Belongs to the universal ribosomal protein uS2 family
HAH_RS04060	COG2124	cytochrome p450
HAH_RS04065	COG1366	Belongs to the anti-sigma-factor antagonist family
HAH_RS04065	COG2202	Pas domain
HAH_RS04070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HAH_RS04075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HAH_RS04090	COG0142	geranyltranstransferase activity
HAH_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HAH_RS04115	COG0657	acetylesterase activity
HAH_RS04135	COG0644	oxidoreductase
HAH_RS04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAH_RS04155	COG0318	PFAM AMP-dependent synthetase and ligase
HAH_RS04165	COG1444	tRNA N-acetyltransferase activity
HAH_RS04170	COG2070	2-Nitropropane dioxygenase
HAH_RS04190	COG0105	UTP biosynthetic process
HAH_RS04215	COG0456	acetyltransferase
HAH_RS04265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HAH_RS04270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HAH_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS04305	COG0028	Belongs to the TPP enzyme family
HAH_RS04310	COG2135	peptidase activity
HAH_RS04345	COG1053	succinate dehydrogenase
HAH_RS04350	COG1757	Na H antiporter
HAH_RS04355	COG3842	ATPase activity
HAH_RS04360	COG1178	ABC-type Fe3 transport system permease component
HAH_RS04390	COG1914	H( )-stimulated, divalent metal cation uptake system
HAH_RS04405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HAH_RS04450	COG0442	prolyl-tRNA aminoacylation
HAH_RS04460	COG0517	IMP dehydrogenase activity
HAH_RS04465	COG0067	glutamate synthase
HAH_RS04465	COG0070	glutamate synthase
HAH_RS04465	COG0069	glutamate synthase activity
HAH_RS04480	COG1088	dTDP-glucose 4,6-dehydratase activity
HAH_RS04490	COG1472	Belongs to the glycosyl hydrolase 3 family
HAH_RS04505	COG1505	serine-type exopeptidase activity
HAH_RS04520	COG1757	Na H antiporter
HAH_RS04530	COG0840	transmembrane signaling receptor activity
HAH_RS04540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HAH_RS04590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HAH_RS04595	COG0019	diaminopimelate decarboxylase activity
HAH_RS04610	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS04620	COG2171	N-acyltransferase activity
HAH_RS04625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HAH_RS04670	COG4122	O-methyltransferase activity
HAH_RS04715	COG0366	Alpha amylase catalytic
HAH_RS04745	COG1414	Transcriptional regulator
HAH_RS04760	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS04800	COG0531	amino acid
HAH_RS04805	COG0569	domain protein
HAH_RS04810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HAH_RS04815	COG2205	protein histidine kinase activity
HAH_RS04825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAH_RS04835	COG0577	efflux transmembrane transporter activity
HAH_RS04835	COG1136	(ABC) transporter
HAH_RS04840	COG1136	(ABC) transporter
HAH_RS04840	COG0577	efflux transmembrane transporter activity
HAH_RS04850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HAH_RS04860	COG2890	protein-(glutamine-N5) methyltransferase activity
HAH_RS04865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HAH_RS04900	COG1024	Enoyl-CoA hydratase
HAH_RS04900	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAH_RS04905	COG1082	Xylose isomerase domain protein TIM barrel
HAH_RS04920	COG0673	inositol 2-dehydrogenase activity
HAH_RS04925	COG0012	GTP binding
HAH_RS04935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HAH_RS04940	COG0316	Belongs to the HesB IscA family
HAH_RS04980	COG0737	Belongs to the 5'-nucleotidase family
HAH_RS04990	COG0668	transmembrane transport
HAH_RS05045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAH_RS05060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HAH_RS05075	COG0129	dihydroxy-acid dehydratase activity
HAH_RS05085	COG1902	pentaerythritol trinitrate reductase activity
HAH_RS05150	COG1233	COG1233 Phytoene dehydrogenase and related
HAH_RS05190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HAH_RS05195	COG0028	Belongs to the TPP enzyme family
HAH_RS05200	COG0440	acetolactate synthase activity
HAH_RS05215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HAH_RS05220	COG0066	3-isopropylmalate dehydratase activity
HAH_RS05230	COG0473	3-isopropylmalate dehydrogenase activity
HAH_RS05235	COG1349	DNA-binding transcription factor activity
HAH_RS05250	COG1830	Aldolase
HAH_RS05280	COG0484	heat shock protein binding
HAH_RS05295	COG0745	RESPONSE REGULATOR receiver
HAH_RS05310	COG0644	oxidoreductase
HAH_RS05315	COG0745	RESPONSE REGULATOR receiver
HAH_RS05320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HAH_RS05335	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HAH_RS05360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HAH_RS05370	COG0778	Nitroreductase
HAH_RS05385	COG0745	RESPONSE REGULATOR receiver
HAH_RS05410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HAH_RS05440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HAH_RS05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAH_RS05475	COG0697	spore germination
HAH_RS05480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HAH_RS05495	COG0179	Fumarylacetoacetate (FAA) hydrolase
HAH_RS05520	COG3046	protein related to deoxyribodipyrimidine photolyase
HAH_RS05525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HAH_RS05545	COG1121	(ABC) transporter
HAH_RS05550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HAH_RS05560	COG2119	membrane
HAH_RS05580	COG0693	protein deglycase activity
HAH_RS05585	COG0647	UMP catabolic process
HAH_RS05590	COG4191	Histidine kinase
HAH_RS05600	COG3361	conserved protein (COG2071)
HAH_RS05605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HAH_RS05615	COG0667	Aldo Keto reductase
HAH_RS05640	COG4555	ABC transporter
HAH_RS05650	COG4191	Histidine kinase
HAH_RS05660	COG2205	protein histidine kinase activity
HAH_RS05665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HAH_RS05675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HAH_RS05690	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HAH_RS05700	COG1793	dna ligase
HAH_RS05705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HAH_RS05730	COG0187	DNA topoisomerase II activity
HAH_RS05760	COG1252	NADH dehydrogenase
HAH_RS05775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAH_RS05805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HAH_RS05860	COG0463	Glycosyl transferase, family 2
HAH_RS05885	COG0438	transferase activity, transferring glycosyl groups
HAH_RS05895	COG3119	arylsulfatase activity
HAH_RS05900	COG1378	Sugar-specific transcriptional regulator TrmB
HAH_RS05905	COG1215	transferase activity, transferring glycosyl groups
HAH_RS05940	COG3852	Histidine kinase
HAH_RS05945	COG0784	Response regulator, receiver
HAH_RS05950	COG4251	negative regulation of phosphorylation
HAH_RS06030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAH_RS06035	COG0010	Belongs to the arginase family
HAH_RS06050	COG0765	amino acid transport
HAH_RS06110	COG0469	pyruvate kinase activity
HAH_RS06135	COG1653	transport
HAH_RS06140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HAH_RS06150	COG0247	lactate metabolic process
HAH_RS06200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HAH_RS06210	COG4191	Histidine kinase
HAH_RS06215	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS06260	COG1132	(ABC) transporter
HAH_RS06280	COG0616	signal peptide processing
HAH_RS06305	COG0346	lactoylglutathione lyase activity
HAH_RS06310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS06310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS06315	COG1047	Peptidyl-prolyl cis-trans
HAH_RS06330	COG1137	ATPase activity
HAH_RS06335	COG0411	ABC transporter
HAH_RS06345	COG0559	Belongs to the binding-protein-dependent transport system permease family
HAH_RS06355	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS06360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS06370	COG0175	sulfate reduction
HAH_RS06390	COG3976	FMN-binding domain protein
HAH_RS06390	COG1053	succinate dehydrogenase
HAH_RS06430	COG0577	efflux transmembrane transporter activity
HAH_RS06430	COG1136	(ABC) transporter
HAH_RS06435	COG1136	(ABC) transporter
HAH_RS06450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HAH_RS06450	COG1796	DNA polymerase
HAH_RS06465	COG2204	response regulator
HAH_RS06475	COG1515	deoxyribonuclease V activity
HAH_RS06480	COG0300	oxidoreductase activity
HAH_RS06505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HAH_RS06515	COG4865	methylaspartate mutase activity
HAH_RS06535	COG0436	Aminotransferase
HAH_RS06540	COG1058	Belongs to the CinA family
HAH_RS06540	COG1546	Belongs to the CinA family
HAH_RS06580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HAH_RS06595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HAH_RS06600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HAH_RS06605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAH_RS06610	COG0512	Glutamine amidotransferase of anthranilate synthase
HAH_RS06610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HAH_RS06620	COG1874	Beta-galactosidase
HAH_RS06620	COG0366	Alpha amylase catalytic
HAH_RS06640	COG0589	response to stress
HAH_RS06650	COG0674	pyruvate-flavodoxin oxidoreductase activity
HAH_RS06650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HAH_RS06655	COG1013	pyruvate-flavodoxin oxidoreductase activity
HAH_RS06660	COG2226	methyltransferase
HAH_RS06665	COG0415	Belongs to the DNA photolyase family
HAH_RS06690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HAH_RS06710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HAH_RS06715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HAH_RS06750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HAH_RS06760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HAH_RS06800	COG0517	IMP dehydrogenase activity
HAH_RS06800	COG0516	GMP reductase activity
HAH_RS06840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAH_RS06850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAH_RS06890	COG1960	acyl-CoA dehydrogenase activity
HAH_RS06895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAH_RS06900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HAH_RS06920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAH_RS06940	COG1960	acyl-CoA dehydrogenase activity
HAH_RS06975	COG0596	Alpha beta hydrolase
HAH_RS06985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS06995	COG4191	Histidine kinase
HAH_RS07010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HAH_RS07020	COG1363	Peptidase, m42
HAH_RS07035	COG1420	regulation of RNA biosynthetic process
HAH_RS07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS07105	COG1546	Belongs to the CinA family
HAH_RS07105	COG1058	Belongs to the CinA family
HAH_RS07120	COG0559	Belongs to the binding-protein-dependent transport system permease family
HAH_RS07150	COG0415	Belongs to the DNA photolyase family
HAH_RS07155	COG1024	Enoyl-CoA hydratase
HAH_RS07180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HAH_RS07195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HAH_RS07220	COG1575	Belongs to the MenA family. Type 1 subfamily
HAH_RS07225	COG0318	PFAM AMP-dependent synthetase and ligase
HAH_RS07230	COG2202	Pas domain
HAH_RS07230	COG1366	Belongs to the anti-sigma-factor antagonist family
HAH_RS07255	COG1881	PFAM PEBP family protein
HAH_RS07260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HAH_RS07315	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HAH_RS07325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HAH_RS07355	COG1960	acyl-CoA dehydrogenase activity
HAH_RS07370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HAH_RS07375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HAH_RS07380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAH_RS07390	COG1845	cytochrome c oxidase, subunit III
HAH_RS07395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HAH_RS07400	COG1748	Saccharopine dehydrogenase
HAH_RS07410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HAH_RS07415	COG0857	belongs to the CobB CobQ family
HAH_RS07430	COG0783	Belongs to the Dps family
HAH_RS07475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HAH_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS07490	COG1840	ABC-type Fe3 transport system, periplasmic component
HAH_RS07530	COG1653	transport
HAH_RS07540	COG0673	inositol 2-dehydrogenase activity
HAH_RS07550	COG3842	ATPase activity
HAH_RS07575	COG0667	Aldo Keto reductase
HAH_RS07585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HAH_RS07595	COG0183	Belongs to the thiolase family
HAH_RS07605	COG2267	carboxylic ester hydrolase activity
HAH_RS07610	COG1703	isobutyryl-CoA mutase activity
HAH_RS07615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS07615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS07620	COG1216	Glycosyl transferase, family 2
HAH_RS07690	COG0714	Associated with various cellular activities
HAH_RS07710	COG3402	PFAM membrane-flanked domain
HAH_RS07720	COG1201	RNA secondary structure unwinding
HAH_RS07735	COG2890	protein-(glutamine-N5) methyltransferase activity
HAH_RS07740	COG1234	tRNA 3'-trailer cleavage
HAH_RS07745	COG2205	protein histidine kinase activity
HAH_RS07800	COG3290	protein histidine kinase activity
HAH_RS07800	COG0840	transmembrane signaling receptor activity
HAH_RS07810	COG1185	polyribonucleotide nucleotidyltransferase activity
HAH_RS07830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS07835	COG0456	acetyltransferase
HAH_RS07850	COG3852	Histidine kinase
HAH_RS07860	COG1285	pathogenesis
HAH_RS07865	COG4191	Histidine kinase
HAH_RS07885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HAH_RS07895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HAH_RS07920	COG0483	inositol monophosphate 1-phosphatase activity
HAH_RS07955	COG0714	Associated with various cellular activities
HAH_RS07975	COG1136	(ABC) transporter
HAH_RS08120	COG0438	transferase activity, transferring glycosyl groups
HAH_RS08140	COG2766	serine protein kinase
HAH_RS08160	COG0432	Pfam Uncharacterised protein family UPF0047
HAH_RS08165	COG1022	Amp-dependent synthetase and ligase
HAH_RS08180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAH_RS08200	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAH_RS08205	COG1960	acyl-CoA dehydrogenase activity
HAH_RS08215	COG1045	serine acetyltransferase
HAH_RS08255	COG0189	ligase activity
HAH_RS08275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HAH_RS08305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HAH_RS08310	COG1797	cobyrinic acid a,c-diamide synthase activity
HAH_RS08325	COG0110	maltose O-acetyltransferase activity
HAH_RS08330	COG0151	Belongs to the GarS family
HAH_RS08340	COG1331	Highly conserved protein containing a thioredoxin domain
HAH_RS08355	COG3852	Histidine kinase
HAH_RS08370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAH_RS08385	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HAH_RS08415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HAH_RS08425	COG0492	ferredoxin-NADP+ reductase activity
HAH_RS08460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HAH_RS08465	COG1201	RNA secondary structure unwinding
HAH_RS08485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAH_RS08520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAH_RS08540	COG0631	protein serine/threonine phosphatase activity
HAH_RS08545	COG2815	serine threonine protein kinase
HAH_RS08545	COG0515	serine threonine protein kinase
HAH_RS08550	COG2304	oxidoreductase activity
HAH_RS08570	COG2514	catechol 2,3-dioxygenase activity
HAH_RS08585	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HAH_RS08590	COG1254	Belongs to the acylphosphatase family
HAH_RS08595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HAH_RS08595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HAH_RS08600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HAH_RS08605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HAH_RS08650	COG0494	nUDIX hydrolase
HAH_RS08660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HAH_RS08665	COG0725	ABC transporter, periplasmic molybdate-binding protein
HAH_RS08670	COG4149	molybdate abc transporter
HAH_RS08675	COG0314	molybdopterin synthase activity
HAH_RS08680	COG0315	cyclic pyranopterin monophosphate synthase activity
HAH_RS08685	COG0521	Mo-molybdopterin cofactor biosynthetic process
HAH_RS08700	COG1418	mRNA catabolic process
HAH_RS08730	COG0243	molybdopterin cofactor binding
HAH_RS08735	COG1140	nitrate reductase beta subunit
HAH_RS08760	COG0489	protein tyrosine kinase activity
HAH_RS08765	COG2860	membrane
HAH_RS08785	COG0243	molybdopterin cofactor binding
HAH_RS08820	COG0714	Associated with various cellular activities
HAH_RS08830	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HAH_RS08835	COG0540	Belongs to the ATCase OTCase family
HAH_RS08860	COG1047	Peptidyl-prolyl cis-trans
HAH_RS08865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HAH_RS08875	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HAH_RS08890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HAH_RS08955	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HAH_RS08960	COG0436	Aminotransferase
HAH_RS08965	COG1522	sequence-specific DNA binding
HAH_RS08995	COG0318	PFAM AMP-dependent synthetase and ligase
HAH_RS09030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HAH_RS09030	COG0674	pyruvate-flavodoxin oxidoreductase activity
HAH_RS09035	COG1013	pyruvate-flavodoxin oxidoreductase activity
HAH_RS09040	COG1522	sequence-specific DNA binding
HAH_RS09045	COG0517	IMP dehydrogenase activity
HAH_RS09045	COG0617	tRNA 3'-terminal CCA addition
HAH_RS09045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HAH_RS09055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS09055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAH_RS09070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAH_RS09095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HAH_RS09115	COG0501	Belongs to the peptidase M48B family
HAH_RS09135	COG0215	cysteine-tRNA ligase activity
HAH_RS09145	COG0598	Magnesium transport protein CorA
HAH_RS09170	COG0303	'Molybdopterin
HAH_RS09180	COG1252	NADH dehydrogenase
HAH_RS09195	COG1832	CoA-binding protein
HAH_RS09210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HAH_RS09220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HAH_RS09235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HAH_RS09300	COG0437	4 iron, 4 sulfur cluster binding
HAH_RS09335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS09370	COG0668	transmembrane transport
HAH_RS09395	COG0297	glycogen (starch) synthase activity
HAH_RS09405	COG0501	Belongs to the peptidase M48B family
HAH_RS09410	COG0154	amidase activity
HAH_RS09415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAH_RS09425	COG1051	belongs to the nudix hydrolase family
HAH_RS09440	COG0587	DNA-directed DNA polymerase activity
HAH_RS09445	COG0535	radical SAM domain protein
HAH_RS09515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAH_RS09520	COG2205	protein histidine kinase activity
HAH_RS09535	COG0107	imidazoleglycerol-phosphate synthase activity
HAH_RS09560	COG1845	cytochrome c oxidase, subunit III
HAH_RS09575	COG1063	alcohol dehydrogenase
HAH_RS09600	COG0411	ABC transporter
HAH_RS09620	COG0471	metal ion transport
HAH_RS09665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HAH_RS09675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HAH_RS09680	COG0081	regulation of translation
HAH_RS09685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HAH_RS09765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HAH_RS09775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HAH_RS09790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HAH_RS09790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HAH_RS09815	COG2233	PERMEase
HAH_RS09825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HAH_RS09830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS09835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS09840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS09840	COG0649	NAD binding
HAH_RS09875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS09880	COG1007	ATP synthesis coupled electron transport
HAH_RS09905	COG0492	ferredoxin-NADP+ reductase activity
HAH_RS09950	COG1621	beta-fructofuranosidase activity
HAH_RS09980	COG1192	Involved in chromosome partitioning
HAH_RS09990	COG1252	NADH dehydrogenase
HAH_RS10000	COG2096	Adenosyltransferase
HAH_RS10005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAH_RS10015	COG0745	RESPONSE REGULATOR receiver
HAH_RS10020	COG4191	Histidine kinase
HAH_RS10025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HAH_RS10035	COG0509	glycine decarboxylation via glycine cleavage system
HAH_RS10040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HAH_RS10065	COG0581	inorganic phosphate transmembrane transporter activity
HAH_RS10070	COG0573	inorganic phosphate transmembrane transporter activity
HAH_RS10075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HAH_RS10105	COG0284	orotidine-5'-phosphate decarboxylase activity
HAH_RS10120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAH_RS10120	COG0512	Glutamine amidotransferase of anthranilate synthase
HAH_RS10125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAH_RS10130	COG0135	phosphoribosylanthranilate isomerase activity
HAH_RS10165	COG2130	NADP-dependent
HAH_RS10170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS10180	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HAH_RS10200	COG0704	Plays a role in the regulation of phosphate uptake
HAH_RS10210	COG0569	domain protein
HAH_RS10265	COG1215	transferase activity, transferring glycosyl groups
HAH_RS10365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HAH_RS10370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HAH_RS10380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HAH_RS10395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HAH_RS10400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HAH_RS10410	COG0255	Belongs to the universal ribosomal protein uL29 family
HAH_RS10415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HAH_RS10430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HAH_RS10435	COG0089	rRNA binding
HAH_RS10445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HAH_RS10470	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HAH_RS10480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAH_RS10490	COG0484	heat shock protein binding
HAH_RS10510	COG2204	response regulator
HAH_RS10530	COG3279	Response regulator of the LytR AlgR family
HAH_RS10550	COG0300	oxidoreductase activity
HAH_RS10580	COG1196	nuclear chromosome segregation
HAH_RS10590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAH_RS10605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HAH_RS10630	COG0531	amino acid
HAH_RS10650	COG1131	(ABC) transporter
HAH_RS10660	COG0017	Asparaginyl-tRNA synthetase
HAH_RS10675	COG0656	L-ascorbic acid biosynthetic process
HAH_RS10795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HAH_RS10830	COG0714	Associated with various cellular activities
HAH_RS10850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HAH_RS10880	COG2154	pterin-4-alpha-carbinolamine dehydratase
HAH_RS10885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HAH_RS10910	COG1278	Cold shock
HAH_RS10915	COG1278	Cold shock
HAH_RS10920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HAH_RS10975	COG0525	valine-tRNA ligase activity
HAH_RS10985	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HAH_RS11025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HAH_RS11055	COG2255	four-way junction helicase activity
HAH_RS11090	COG0281	malic enzyme
HAH_RS11090	COG0280	phosphate acetyltransferase
HAH_RS11105	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HAH_RS11110	COG0585	pseudouridine synthase activity
HAH_RS11120	COG2031	fatty acid transporter
HAH_RS11125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HAH_RS11135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HAH_RS11155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HAH_RS11175	COG0717	Belongs to the dCTP deaminase family
HAH_RS11220	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HAH_RS11240	COG0010	Belongs to the arginase family
HAH_RS11245	COG1228	amidohydrolase
HAH_RS11250	COG2986	histidine ammonia-lyase
HAH_RS11255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAH_RS11265	COG0384	phenazine biosynthesis protein PhzF
HAH_RS11280	COG0076	glutamate decarboxylase activity
HAH_RS11290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HAH_RS11290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HAH_RS11305	COG0330	HflC and HflK could
HAH_RS11345	COG2226	methyltransferase
HAH_RS11360	COG0459	protein refolding
HAH_RS11370	COG3250	beta-galactosidase activity
HAH_RS11415	COG0719	Fe-S assembly protein
HAH_RS11420	COG0719	Fe-S assembly protein
HAH_RS11425	COG0396	ATPase activity
HAH_RS11430	COG0417	DNA replication proofreading
HAH_RS11450	COG0419	ATPase involved in DNA repair
HAH_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAH_RS11520	COG0667	Aldo Keto reductase
HAH_RS11560	COG1132	(ABC) transporter
HAH_RS11565	COG1757	Na H antiporter
HAH_RS11580	COG0463	Glycosyl transferase, family 2
HAH_RS11600	COG0710	3-dehydroquinate dehydratase activity
HAH_RS11610	COG1465	3-dehydroquinate synthase
HAH_RS11620	COG0159	tryptophan synthase activity
HAH_RS11625	COG0133	tryptophan synthase activity
HAH_RS11630	COG0134	indole-3-glycerol-phosphate synthase activity
HAH_RS11640	COG0012	GTP binding
HAH_RS11645	COG0840	transmembrane signaling receptor activity
HAH_RS11690	COG4716	Myosin-crossreactive antigen
HAH_RS11695	COG1253	flavin adenine dinucleotide binding
HAH_RS11730	COG0667	Aldo Keto reductase
HAH_RS11760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HAH_RS11800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HAH_RS11810	COG0596	Alpha beta hydrolase
HAH_RS11815	COG0402	S-adenosylhomocysteine deaminase activity
HAH_RS11820	COG0010	Belongs to the arginase family
HAH_RS11840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HAH_RS11850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HAH_RS11875	COG1492	cobalamin metabolic process
HAH_RS11880	COG0489	protein tyrosine kinase activity
HAH_RS11900	COG0415	Belongs to the DNA photolyase family
HAH_RS11965	COG4221	oxidoreductase activity
HAH_RS11970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HAH_RS11995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HAH_RS12015	COG1414	Transcriptional regulator
HAH_RS12025	COG0346	lactoylglutathione lyase activity
HAH_RS12030	COG0247	lactate metabolic process
HAH_RS12030	COG0277	FAD linked oxidase domain protein
HAH_RS12040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HAH_RS12060	COG0318	PFAM AMP-dependent synthetase and ligase
HAH_RS12065	COG1024	Enoyl-CoA hydratase
HAH_RS12075	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAH_RS12080	COG1960	acyl-CoA dehydrogenase activity
HAH_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS12095	COG2030	dehydratase
HAH_RS12100	COG1960	acyl-CoA dehydrogenase activity
HAH_RS12135	COG0667	Aldo Keto reductase
HAH_RS12140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HAH_RS12145	COG4974	Belongs to the 'phage' integrase family
HAH_RS12185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HAH_RS12190	COG0037	tRNA processing
HAH_RS12235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HAH_RS12250	COG0095	Lipoate-protein ligase
HAH_RS12265	COG0649	NAD binding
HAH_RS12265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS12310	COG0747	negative chemotaxis
HAH_RS12315	COG0601	transmembrane transport
HAH_RS12320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAH_RS12325	COG0444	Belongs to the ABC transporter superfamily
HAH_RS12330	COG4608	Belongs to the ABC transporter superfamily
HAH_RS12345	COG0616	signal peptide processing
HAH_RS12350	COG0667	Aldo Keto reductase
HAH_RS12385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAH_RS12390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HAH_RS12465	COG0557	exoribonuclease II activity
HAH_RS12485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAH_RS12485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAH_RS12515	COG0842	Transport permease protein
HAH_RS12520	COG1131	(ABC) transporter
HAH_RS12540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HAH_RS12550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HAH_RS12560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HAH_RS12575	COG3403	YqcI/YcgG family
HAH_RS12580	COG1335	isochorismatase
HAH_RS12595	COG3842	ATPase activity
HAH_RS12630	COG0745	RESPONSE REGULATOR receiver
HAH_RS12635	COG3118	belongs to the thioredoxin family
HAH_RS12665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HAH_RS12690	COG0644	oxidoreductase
HAH_RS12705	COG2897	thiosulfate sulfurtransferase activity
HAH_RS12740	COG1253	flavin adenine dinucleotide binding
HAH_RS12760	COG0352	thiamine-phosphate diphosphorylase activity
HAH_RS12770	COG0704	Plays a role in the regulation of phosphate uptake
HAH_RS12780	COG0581	inorganic phosphate transmembrane transporter activity
HAH_RS12785	COG0573	inorganic phosphate transmembrane transporter activity
HAH_RS12790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HAH_RS12805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAH_RS12835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HAH_RS12860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HAH_RS12865	COG0602	queuosine metabolic process
HAH_RS12885	COG2234	aminopeptidase activity
HAH_RS12915	COG0702	epimerase
HAH_RS12925	COG0633	Ferredoxin
HAH_RS12935	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HAH_RS12950	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HAH_RS12975	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HAH_RS12985	COG2201	protein-glutamate methylesterase activity
HAH_RS13025	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HAH_RS13035	COG2201	protein-glutamate methylesterase activity
HAH_RS13040	COG0643	Histidine kinase
HAH_RS13040	COG2198	Histidine kinase
HAH_RS13045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HAH_RS13140	COG0601	transmembrane transport
HAH_RS13145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAH_RS13155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HAH_RS13205	COG1994	Peptidase M50
HAH_RS13205	COG0517	IMP dehydrogenase activity
HAH_RS13210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HAH_RS13215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HAH_RS13220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HAH_RS13240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HAH_RS13245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HAH_RS13260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HAH_RS13265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HAH_RS13300	COG0210	DNA helicase
HAH_RS13315	COG1695	Transcriptional regulator
HAH_RS13345	COG0346	lactoylglutathione lyase activity
HAH_RS13355	COG1122	ATPase activity
HAH_RS13370	COG0310	cobalt ion transport
HAH_RS13375	COG0864	Transcriptional regulator
HAH_RS13430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAH_RS13465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAH_RS13485	COG1132	(ABC) transporter
HAH_RS13515	COG2226	methyltransferase
HAH_RS13535	COG3290	protein histidine kinase activity
HAH_RS13540	COG1278	Cold shock
HAH_RS13545	COG1278	Cold shock
HAH_RS13560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HAH_RS13570	COG3833	ABC-type maltose transport systems, permease component
HAH_RS13575	COG1175	transmembrane transport
HAH_RS13590	COG3842	ATPase activity
HAH_RS13610	COG0435	Glutathione S-transferase
HAH_RS13625	COG0589	response to stress
HAH_RS13630	COG0189	ligase activity
HAH_RS13645	COG0126	phosphoglycerate kinase activity
HAH_RS13655	COG2339	peptidase activity
HAH_RS13660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HAH_RS13665	COG0140	phosphoribosyl-ATP diphosphatase activity
HAH_RS13680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HAH_RS13695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HAH_RS13715	COG2255	four-way junction helicase activity
HAH_RS13815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAH_RS13820	COG0460	homoserine dehydrogenase
HAH_RS13840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HAH_RS13845	COG0626	cystathionine gamma-synthase activity
HAH_RS13855	COG2202	Pas domain
HAH_RS13855	COG3920	Histidine kinase
HAH_RS13865	COG1122	ATPase activity
HAH_RS13870	COG1268	BioY protein
HAH_RS13880	COG0049	tRNA binding
HAH_RS13890	COG0840	transmembrane signaling receptor activity
HAH_RS13905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAH_RS13910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAH_RS13915	COG0085	RNA polymerase activity
HAH_RS13955	COG0778	Nitroreductase
HAH_RS13955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HAH_RS13960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAH_RS13970	COG3033	Beta-eliminating lyase
HAH_RS13975	COG2226	methyltransferase
HAH_RS13985	COG0714	Associated with various cellular activities
HAH_RS13990	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HAH_RS13995	COG1305	Transglutaminase-like
HAH_RS14015	COG0351	phosphomethylpyrimidine kinase
HAH_RS14020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HAH_RS14035	COG0589	response to stress
HAH_RS14055	COG0110	maltose O-acetyltransferase activity
HAH_RS14065	COG3852	Histidine kinase
HAH_RS14095	COG0559	Belongs to the binding-protein-dependent transport system permease family
HAH_RS14105	COG3938	Belongs to the proline racemase family
HAH_RS14120	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS14135	COG2205	protein histidine kinase activity
HAH_RS14145	COG1607	acyl-coa hydrolase
HAH_RS14175	COG1024	Enoyl-CoA hydratase
HAH_RS14185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HAH_RS14210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HAH_RS14220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HAH_RS14225	COG4221	oxidoreductase activity
HAH_RS14240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HAH_RS14250	COG1234	tRNA 3'-trailer cleavage
HAH_RS14255	COG0673	inositol 2-dehydrogenase activity
HAH_RS14270	COG0346	lactoylglutathione lyase activity
HAH_RS14290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HAH_RS14300	COG0372	Belongs to the citrate synthase family
HAH_RS14350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HAH_RS14355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAH_RS14365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HAH_RS14375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HAH_RS14380	COG0306	phosphate transporter
HAH_RS14390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HAH_RS14395	COG1082	Xylose isomerase domain protein TIM barrel
HAH_RS14410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAH_RS14415	COG2205	protein histidine kinase activity
HAH_RS14420	COG1131	(ABC) transporter
HAH_RS14470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HAH_RS14485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HAH_RS14490	COG1739	Uncharacterized protein family UPF0029
HAH_RS14505	COG0131	Imidazoleglycerol-phosphate dehydratase
HAH_RS14525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HAH_RS14535	COG2255	four-way junction helicase activity
HAH_RS14555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAH_RS14560	COG2827	Endonuclease containing a URI domain
HAH_RS14565	COG1691	(AIR) carboxylase
HAH_RS14575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HAH_RS14585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAH_RS14600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HAH_RS14615	COG2358	TRAP transporter, solute receptor (TAXI family
HAH_RS14635	COG0306	phosphate transporter
HAH_RS14650	COG1966	Carbon starvation protein
HAH_RS14665	COG0523	cobalamin synthesis protein
HAH_RS14710	COG0009	L-threonylcarbamoyladenylate synthase
HAH_RS14725	COG0247	lactate metabolic process
HAH_RS14725	COG2181	nitrate reductase activity
HAH_RS14740	COG1058	Belongs to the CinA family
HAH_RS14740	COG1546	Belongs to the CinA family
HAH_RS14745	COG0113	porphobilinogen synthase activity
HAH_RS14770	COG2205	protein histidine kinase activity
HAH_RS14775	COG0840	transmembrane signaling receptor activity
HAH_RS14780	COG0004	ammonium transporteR
HAH_RS14785	COG0347	Belongs to the P(II) protein family
HAH_RS14790	COG1522	sequence-specific DNA binding
HAH_RS14810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HAH_RS14820	COG0243	molybdopterin cofactor binding
HAH_RS14825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HAH_RS14835	COG0745	RESPONSE REGULATOR receiver
HAH_RS14840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HAH_RS14845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HAH_RS14860	COG0537	adenosine 5'-monophosphoramidase activity
HAH_RS14900	COG0495	leucyl-tRNA aminoacylation
HAH_RS14905	COG1079	Belongs to the binding-protein-dependent transport system permease family
HAH_RS14910	COG4603	Belongs to the binding-protein-dependent transport system permease family
HAH_RS14915	COG3845	ABC transporter
HAH_RS14920	COG1744	ABC transporter substrate-binding protein PnrA-like
HAH_RS14950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HAH_RS14955	COG0527	aspartate kinase activity
HAH_RS14975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HAH_RS14990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HAH_RS14995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HAH_RS15000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HAH_RS15005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HAH_RS15010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HAH_RS15015	COG0189	ligase activity
HAH_RS15025	COG0165	Argininosuccinate lyase
HAH_RS15030	COG0137	argininosuccinate synthase activity
HAH_RS15055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAH_RS15070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HAH_RS15080	COG0423	glycine-tRNA ligase activity
HAH_RS15090	COG0556	nucleotide-excision repair
HAH_RS15115	COG1160	GTP binding
HAH_RS15130	COG2217	Heavy metal translocating P-type atpase
HAH_RS15135	COG0589	response to stress
HAH_RS15225	COG1074	ATP-dependent DNA helicase activity
HAH_RS15255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HAH_RS15860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HAH_RS15865	COG1518	maintenance of DNA repeat elements
HAH_RS16015	COG0443	Heat shock 70 kDa protein
HAH_RS16135	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HAH_RS16170	COG2894	cell division
HAH_RS16180	COG0531	amino acid
HAH_RS16195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAH_RS16200	COG0569	domain protein
HAH_RS16205	COG0475	glutathione-regulated potassium exporter activity
HAH_RS16225	COG0531	amino acid
HAH_RS16230	COG0569	domain protein
HAH_RS16375	COG1253	flavin adenine dinucleotide binding
HAH_RS16380	COG0778	Nitroreductase
HAH_RS16380	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HAH_RS16425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HAH_RS16440	COG1570	exodeoxyribonuclease VII activity
HAH_RS16445	COG1192	Involved in chromosome partitioning
HAH_RS16465	COG1132	(ABC) transporter
HAH_RS16475	COG0174	glutamine synthetase
HAH_RS16550	COG0589	response to stress
HAH_RS16575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HAH_RS16590	COG0410	ABC transporter
HAH_RS16610	COG0436	Aminotransferase
HAH_RS16630	COG0006	proline dipeptidase activity
HAH_RS16645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS16655	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS16680	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS16685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HAH_RS16695	COG1175	transmembrane transport
HAH_RS16700	COG0395	ABC-type sugar transport system, permease component
HAH_RS16705	COG1472	Belongs to the glycosyl hydrolase 3 family
HAH_RS16710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HAH_RS16720	COG3842	ATPase activity
HAH_RS16740	COG0559	Belongs to the binding-protein-dependent transport system permease family
HAH_RS16770	COG1024	Enoyl-CoA hydratase
HAH_RS16775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAH_RS16780	COG0183	Belongs to the thiolase family
HAH_RS16795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HAH_RS16810	COG1012	belongs to the aldehyde dehydrogenase family
HAH_RS16815	COG2151	metal-sulfur cluster biosynthetic enzyme
HAH_RS16840	COG1024	Enoyl-CoA hydratase
HAH_RS16860	COG2030	dehydratase
HAH_RS16865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HAH_RS16870	COG0439	Biotin carboxylase
HAH_RS16880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAH_RS16890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HAH_RS16905	COG3174	membrane
HAH_RS16940	COG1653	transport
HAH_RS16945	COG1175	transmembrane transport
HAH_RS16950	COG0395	ABC-type sugar transport system, permease component
HAH_RS16955	COG3842	ATPase activity
HAH_RS16965	COG0647	UMP catabolic process
HAH_RS16985	COG3639	organic phosphonate transmembrane transporter activity
HAH_RS16995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HAH_RS17015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HAH_RS17050	COG0489	protein tyrosine kinase activity
HAH_RS17115	COG1122	ATPase activity
HAH_RS17170	COG5564	TIM-barrel signal transduction protein
HAH_RS17180	COG1271	oxidase subunit
HAH_RS17190	COG2217	Heavy metal translocating P-type atpase
HAH_RS17280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAH_RS17285	COG0601	transmembrane transport
HAH_RS17290	COG0747	negative chemotaxis
HAH_RS17355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAH_RS17360	COG1120	ATPase activity
HAH_RS17400	COG2894	cell division
HAH_RS17415	COG1414	Transcriptional regulator
HAH_RS17420	COG1757	Na H antiporter
HAH_RS17450	COG1914	H( )-stimulated, divalent metal cation uptake system
HAH_RS17460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAH_RS17470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAH_RS17480	COG0784	Response regulator, receiver
HAH_RS17480	COG2198	Histidine kinase
HAH_RS17480	COG5002	protein histidine kinase activity
HAH_RS17495	COG0516	GMP reductase activity
HAH_RS17495	COG0517	IMP dehydrogenase activity
HAH_RS17505	COG3383	formate dehydrogenase (NAD+) activity
HAH_RS17540	COG0589	response to stress
HAH_RS17555	COG0589	response to stress
HAH_RS17565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HAH_RS17585	COG3118	belongs to the thioredoxin family
HAH_RS17610	COG0425	Belongs to the sulfur carrier protein TusA family
HAH_RS17615	COG2210	Belongs to the sulfur carrier protein TusA family
HAH_RS17630	COG0425	Belongs to the sulfur carrier protein TusA family
HAH_RS17630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAH_RS17635	COG2264	protein methyltransferase activity
HAH_RS17645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HAH_RS17660	COG1073	alpha beta
HAH_RS17660	COG2226	methyltransferase
HAH_RS17665	COG0830	nickel cation binding
HAH_RS17670	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HAH_RS17675	COG0829	nickel cation binding
HAH_RS17685	COG0831	urea catabolic process
HAH_RS17690	COG0804	urea catabolic process
HAH_RS17695	COG0832	Belongs to the urease beta subunit family
HAH_RS17725	COG0733	neurotransmitter:sodium symporter activity
HAH_RS17775	COG2217	Heavy metal translocating P-type atpase
HAH_RS17795	COG0492	ferredoxin-NADP+ reductase activity
HAH_RS17805	COG2133	pyrroloquinoline quinone binding
HAH_RS17815	COG0306	phosphate transporter
HAH_RS17820	COG0531	amino acid
HAH_RS17845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAH_RS17890	COG1131	(ABC) transporter
HAH_RS17915	COG1510	regulation of RNA biosynthetic process
HAH_RS17925	COG3001	Fructosamine kinase
HAH_RS17930	COG2814	Major facilitator Superfamily
HAH_RS17960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HAH_RS17965	COG3002	Belongs to the UPF0753 family
HAH_RS17970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAH_RS17975	COG1063	alcohol dehydrogenase
HAH_RS17980	COG4948	Mandelate Racemase Muconate Lactonizing
HAH_RS17985	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS17990	COG1070	Carbohydrate kinase
HAH_RS18000	COG3842	ATPase activity
HAH_RS18010	COG1175	transmembrane transport
HAH_RS18020	COG1063	alcohol dehydrogenase
HAH_RS18025	COG1414	Transcriptional regulator
HAH_RS18050	COG2379	hydroxypyruvate reductase
HAH_RS18125	COG0463	Glycosyl transferase, family 2
HAH_RS18145	COG0297	glycogen (starch) synthase activity
HAH_RS18150	COG1215	transferase activity, transferring glycosyl groups
HAH_RS18155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAH_RS18155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAH_RS18170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAH_RS18170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HAH_RS18210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HAH_RS18225	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HAH_RS18230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HAH_RS18260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HAH_RS18290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HAH_RS18325	COG1414	Transcriptional regulator
HAH_RS18350	COG0395	ABC-type sugar transport system, permease component
HAH_RS18365	COG1028	Short-chain dehydrogenase reductase Sdr
HAH_RS18370	COG0251	oxidation-reduction process
HAH_RS18385	COG1301	dicarboxylic acid transport
HAH_RS18390	COG1045	serine acetyltransferase
HAH_RS18400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HAH_RS18405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAH_RS18410	COG0512	Glutamine amidotransferase of anthranilate synthase
HAH_RS18410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HAH_RS18415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HAH_RS18420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HAH_RS18430	COG0251	oxidation-reduction process
HAH_RS18440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HAH_RS18445	COG3383	formate dehydrogenase (NAD+) activity
HAH_RS18460	COG1404	Belongs to the peptidase S8 family
HAH_RS18460	COG4412	M6 family metalloprotease domain protein
HAH_RS18500	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HAH_RS18515	COG0534	Mate efflux family protein
HAH_RS18520	COG2226	methyltransferase
HAH_RS18530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HAH_RS18535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HAH_RS18550	COG2226	methyltransferase
HAH_RS18565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAH_RS18585	COG0697	spore germination
HAH_RS18605	COG0501	Belongs to the peptidase M48B family
HAH_RS18635	COG0247	lactate metabolic process
HAH_RS18635	COG0277	FAD linked oxidase domain protein
HAH_RS18640	COG1620	l-lactate permease
HAH_RS18655	COG3634	alkyl hydroperoxide reductase activity
HAH_RS18660	COG1063	alcohol dehydrogenase
HAH_RS18670	COG1120	ATPase activity
HAH_RS18675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAH_RS18700	COG2264	protein methyltransferase activity
HAH_RS18740	COG0402	S-adenosylhomocysteine deaminase activity
HAH_RS18750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HAH_RS18755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAH_RS18760	COG1079	Belongs to the binding-protein-dependent transport system permease family
HAH_RS18765	COG4603	Belongs to the binding-protein-dependent transport system permease family
HAH_RS18770	COG3845	ABC transporter
HAH_RS18785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HAH_RS18800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HAH_RS18820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HAH_RS18840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HAH_RS18840	COG3608	succinylglutamate desuccinylase aspartoacylase
HAH_RS18845	COG0709	Synthesizes selenophosphate from selenide and ATP
HAH_RS18860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAH_RS18865	COG0251	oxidation-reduction process
HAH_RS18870	COG0402	S-adenosylhomocysteine deaminase activity
HAH_RS18900	COG0745	RESPONSE REGULATOR receiver
HAH_RS18930	COG0673	inositol 2-dehydrogenase activity
HAH_RS18935	COG2244	polysaccharide biosynthetic process
HAH_RS18960	COG0438	transferase activity, transferring glycosyl groups
HAH_RS18965	COG3119	arylsulfatase activity
HAH_RS18970	COG0463	Glycosyl transferase, family 2
HAH_RS18980	COG0438	transferase activity, transferring glycosyl groups
HAH_RS18980	COG0297	glycogen (starch) synthase activity
HAH_RS18985	COG0367	asparagine synthase
HAH_RS18990	COG0438	transferase activity, transferring glycosyl groups
HAH_RS19020	COG0673	inositol 2-dehydrogenase activity
HAH_RS19050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAH_RS19095	COG0438	transferase activity, transferring glycosyl groups
HAH_RS19100	COG2244	polysaccharide biosynthetic process
HAH_RS19135	COG3119	arylsulfatase activity
HAH_RS19315	COG0484	heat shock protein binding
HAH_RS19370	COG4608	Belongs to the ABC transporter superfamily
HAH_RS19425	COG3454	Phosphonate metabolism